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Tatsuo Yagyu

Research Profile

Chemicals & Drugs

Disorders

Ovarian Neoplasms

Living Beings

Mouse

Phenomena

Physiology

Anatomy

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Publications

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Seiji Kanayama; Yoshihiko Yamada; Akira Onogi; Hiroshi Shigetomi; Sachiyo Ueda; Yoriko Tsuji; Shoji Haruta; Ryuji Kawaguchi; Shozo Yoshida; Mariko Sakata; Toshiyuki Sado; Takashi Kitanaka; Hidekazu Oi; Tatsuo Yagyu; Hiroshi Kobayashi
Molecular structure and function analysis of bikunin on down-regulation of tumor necrosis factor-alpha expression in activated neutrophils.
Seiji Kanayama; Yoshihiko Yamada; Akira Onogi; Hiroshi Shigetomi; Sachiyo Ueda; Yoriko Tsuji; Shoji Haruta; Ryuji Kawaguchi; Shozo Yoshida; Mariko Sakata; Toshiyuki Sado; Takashi Kitanaka; Hidekazu Oi; Tatsuo Yagyu; Hiroshi Kobayashi
Bikunin suppresses expression of pro-inflammatory cytokines induced by lipopolysaccharide in neutrophils.
Tatsuo Yagyu; Y Tsuji; S Haruta; Takashi Kitanaka; Yoshihiko Yamada; R Kawaguchi; S Kanayama; Y Tanase; Noriyuki Kurita; Hiroshi Kobayashi
Activation of mammalian target of rapamycin in postmenopausal ovarian endometriosis.

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All Publications

2008: Seiji Kanayama; Yoshihiko Yamada; Akira Onogi; Hiroshi Shigetomi; Sachiyo Ueda; Yoriko Tsuji; Shoji Haruta; Ryuji Kawaguchi; Shozo Yoshida; Mariko Sakata; Toshiyuki Sado; Takashi Kitanaka; Hidekazu Oi; Tatsuo Yagyu; Hiroshi Kobayashi
Molecular structure and function analysis of bikunin on down-regulation of tumor necrosis factor-alpha expression in activated neutrophils.
Cytokine 2008;42(2):191-7.
2007: Seiji Kanayama; Yoshihiko Yamada; Akira Onogi; Hiroshi Shigetomi; Sachiyo Ueda; Yoriko Tsuji; Shoji Haruta; Ryuji Kawaguchi; Shozo Yoshida; Mariko Sakata; Toshiyuki Sado; Takashi Kitanaka; Hidekazu Oi; Tatsuo Yagyu; Hiroshi Kobayashi
Bikunin suppresses expression of pro-inflammatory cytokines induced by lipopolysaccharide in neutrophils.
Journal of endotoxin research 2007;13(6):369-76.
2006: Tatsuo Yagyu; Y Tsuji; S Haruta; Takashi Kitanaka; Yoshihiko Yamada; R Kawaguchi; S Kanayama; Y Tanase; Noriyuki Kurita; Hiroshi Kobayashi
Activation of mammalian target of rapamycin in postmenopausal ovarian endometriosis.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2006;16(4):1545-51.
2006: Tatsuo Yagyu; Hiroshi Kobayashi; Hidenori Matsuzaki; Kiyoshi Wakahara; Toshiharu Kondo; Noriyuki Kurita; Hideo Sekino; Kiyokazu Inagaki
Enhanced spontaneous metastasis in bikunin-deficient mice.
International journal of cancer. Journal international du cancer 2006;118(9):2322-8.
2005: Hiroshi Kobayashi; Ryuji Yoshida; Yasufumi Kanada; Yoichi Fukuda; Tatsuo Yagyu; Kiyokazu Inagaki; Toshiharu Kondo; Noriyuki Kurita; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
Suppression of lipopolysaccharide-induced cytokine production of gingival fibroblasts by a soybean, Kunitz trypsin inhibitor.
Journal of periodontal research 2005;40(6):461-8.
2005: Hiroshi Kobayashi; Tatsuo Yagyu; Toshiharu Kondo; Noriyuki Kurita; Kiyokazu Inagaki; Shoji Haruta; Ryuji Kawaguchi; Takashi Kitanaka; Yoshiharu Sakamoto; Yoshihiko Yamada; Naohiro Kanayama; Toshihiko Terao
Suppression of urokinase receptor expression by thalidomide is associated with inhibition of nuclear factor kappaB activation and subsequently suppressed ovarian cancer dissemination.
Cancer research 2005;65(22):10464-71.
2005: Hiroshi Kobayashi; Ryuji Yoshida; Yasufumi Kanada; Yoichi Fukuda; Tatsuo Yagyu; Kiyokazu Inagaki; Toshiharu Kondo; Noriyuki Kurita; Yoshihiko Yamada; Toshiyuki Sado; Takashi Kitanaka; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
A soybean Kunitz trypsin inhibitor reduces tumor necrosis factor-alpha production in ultraviolet-exposed primary human keratinocytes.
Experimental dermatology 2005;14(10):765-74.
2005: Kiyokazu Inagaki; Hiroshi Kobayashi; Ryuji Yoshida; Yasufumi Kanada; Yoichi Fukuda; Tatsuo Yagyu; Toshiharu Kondo; Noriyuki Kurita; Takashi Kitanaka; Yoshihiko Yamada; Yoshiharu Sakamoto; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
Suppression of urokinase expression and invasion by a soybean Kunitz trypsin inhibitor are mediated through inhibition of Src-dependent signaling pathways.
The Journal of biological chemistry 2005;280(36):31428-37.
2005: Hidenori Matsuzaki; Hiroshi Kobayashi; Tatsuo Yagyu; Kiyoshi Wakahara; Toshiharu Kondo; Noriyuki Kurita; Hideo Sekino; Kiyokazu Inagaki; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
Reduced syndecan-1 expression stimulates heparin-binding growth factor-mediated invasion in ovarian cancer cells in a urokinase-independent mechanism.
Oncology reports 2005;14(2):449-57.
2005: Hiroshi Kobayashi; Ryuji Yoshida; Yasufumi Kanada; Yoichi Fukuda; Tatsuo Yagyu; Kiyokazu Inagaki; Toshiharu Kondo; Noriyuki Kurita; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
Suppressing effects of daily oral supplementation of beta-glucan extracted from Agaricus blazei Murill on spontaneous and peritoneal disseminated metastasis in mouse model.
Journal of cancer research and clinical oncology 2005;131(8):527-38.
2005: Hiroshi Kobayashi; Ryuji Yoshida; Yasufumi Kanada; Yoichi Fukuda; Tatsuo Yagyu; Kiyokazu Inagaki; Toshiharu Kondo; Noriyuki Kurita; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
Dietary supplementation of soybean kunitz trypsin inhibitor reduces lipopolysaccharide-induced lethality in mouse model.
Shock (Augusta, Ga.) 2005;23(5):441-7.
2005: Tatsuo Yagyu; Hiroshi Kobayashi; Hidenori Matsuzaki; Kiyoshi Wakahara; Toshiharu Kondo; Noriyuki Kurita; Hideo Sekino; Kiyokazu Inagaki; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
Thalidomide inhibits tumor necrosis factor-alpha-induced interleukin-8 expression in endometriotic stromal cells, possibly through suppression of nuclear factor-kappaB activation.
The Journal of clinical endocrinology and metabolism 2005;90(5):3017-21.
2005: Kiyoshi Wakahara; Hiroshi Kobayashi; Tatsuo Yagyu; Hidenori Matsuzaki; Toshiharu Kondo; Noriyuki Kurita; Hideo Sekino; Kiyokazu Inagaki; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
Bikunin down-regulates heterodimerization between CD44 and growth factor receptors and subsequently suppresses agonist-mediated signaling.
Journal of cellular biochemistry 2005;94(5):995-1009.
2005: Kiyoshi Wakahara; Hiroshi Kobayashi; Tatsuo Yagyu; Hidenori Matsuzaki; Toshiharu Kondo; Noriyuki Kurita; Hideo Sekino; Kiyokazu Inagaki; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
Bikunin suppresses lipopolysaccharide-induced lethality through down-regulation of tumor necrosis factor- alpha and interleukin-1 beta in macrophages.
The Journal of infectious diseases 2005;191(6):930-8.
2005: Hidenori Matsuzaki; Hiroshi Kobayashi; Tatsuo Yagyu; Kiyoshi Wakahara; Toshiharu Kondo; Noriyuki Kurita; Hideo Sekino; Kiyokazu Inagaki; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
Plasma bikunin as a favorable prognostic factor in ovarian cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(7):1463-72.
2004: Hidenori Matsuzaki; Hiroshi Kobayashi; Tatsuo Yagyu; Kiyoshi Wakahara; Toshiharu Kondo; Noriyuki Kurita; Hideo Sekino; Kiyokazu Inagaki; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
Bikunin inhibits lipopolysaccharide-induced tumor necrosis factor alpha induction in macrophages.
Clinical and diagnostic laboratory immunology 2004;11(6):1140-7.
2004: Tatsuo Yagyu; Hiroshi Kobayashi; Kiyoshi Wakahara; Hidenori Matsuzaki; Toshiharu Kondo; Noriyuki Kurita; Hideo Sekino; Kiyokazu Inagaki; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
A kunitz-type protease inhibitor bikunin disrupts ligand-induced oligomerization of receptors for transforming growth factor (TGF)-beta and subsequently suppresses TGF-beta signalings.
FEBS letters 2004;576(3):408-16.
2004: Kiyoshi Wakahara; Hiroshi Kobayashi; Tatsuo Yagyu; Hidenori Matsuzaki; Toshiharu Kondo; Noriyuki Kurita; Hideo Sekino; Kiyokazu Inagaki; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
Transforming growth factor-beta1-dependent activation of Smad2/3 and up-regulation of PAI-1 expression is negatively regulated by Src in SKOV-3 human ovarian cancer cells.
Journal of cellular biochemistry 2004;93(3):437-53.
2004: Hiroshi Kobayashi; Tatsuo Yagyu; Kiyokazu Inagaki; Toshiharu Kondo; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
Bikunin plus paclitaxel markedly reduces tumor burden and ascites in mouse model of ovarian cancer.
International journal of cancer. Journal international du cancer 2004;110(1):134-9.
2004: Hiroshi Kobayashi; Tatsuo Yagyu; Kiyokazu Inagaki; Toshiharu Kondo; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
Therapeutic efficacy of once-daily oral administration of a Kunitz-type protease inhibitor, bikunin, in a mouse model and in human cancer.
Cancer 2004;100(4):869-77.