Kazuhiko Yamada

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Sachs David H; Sykes Megan; Yamada Kazuhiko
Achieving tolerance in pig-to-primate xenotransplantation: reality or fantasy.
Griesemer Adam D; Okumi Masayoshi; Shimizu Akira; Moran Shannon; Ishikawa Yoshinori; Iorio Justin; Arn J Scott; Yamada Kazuhiko
Upregulation of CD59: potential mechanism of accommodation in a large animal model.
Knosalla C; Yazawa K; Behdad A; Bodyak N; Shang H; Bühler L; Houser S; Gollackner B; Griesemer A; Schmitt-Knosalla I; Schuurman H-J; Awwad M; Sachs D H; Cooper D K C; Yamada K; Usheva A; Robson S C
Renal and cardiac endothelial heterogeneity impact acute vascular rejection in pig-to-baboon xenotransplantation.

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All Publications

2009: Sachs David H; Sykes Megan; Yamada Kazuhiko
Achieving tolerance in pig-to-primate xenotransplantation: reality or fantasy.
Transplant immunology 2009;21(2):101-5.
2009: Griesemer Adam D; Okumi Masayoshi; Shimizu Akira; Moran Shannon; Ishikawa Yoshinori; Iorio Justin; Arn J Scott; Yamada Kazuhiko
Upregulation of CD59: potential mechanism of accommodation in a large animal model.
Transplantation 2009;87(9):1308-17.
2009: Knosalla C; Yazawa K; Behdad A; Bodyak N; Shang H; Bühler L; Houser S; Gollackner B; Griesemer A; Schmitt-Knosalla I; Schuurman H-J; Awwad M; Sachs D H; Cooper D K C; Yamada K; Usheva A; Robson S C
Renal and cardiac endothelial heterogeneity impact acute vascular rejection in pig-to-baboon xenotransplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2009;9(5):1006-16.
2008: Hisashi Y; Yamada K; Kuwaki K; Tseng Y-L; Dor F J M F; Houser S L; Robson S C; Schuurman H-J; Cooper D K C; Sachs D H; Colvin R B; Shimizu A
Rejection of cardiac xenografts transplanted from alpha1,3-galactosyltransferase gene-knockout (GalT-KO) pigs to baboons.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2008;8(12):2516-26.
2008: Griesemer Adam D; Lamattina John C; Okumi Masayoshi; Etter Justin D; Shimizu Akira; Sachs David H; Yamada Kazuhiko
Linked suppression across an MHC-mismatched barrier in a miniature swine kidney transplantation model.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(6):4027-36.
2008: Shimizu Akira; Hisashi Yosuke; Kuwaki Kenji; Tseng Yau-Lin; Dor Frank J M F; Houser Stuart L; Robson Simon C; Schuurman Henk-Jan; Cooper David K C; Sachs David H; Yamada Kazuhiko; Colvin Robert B
Thrombotic microangiopathy associated with humoral rejection of cardiac xenografts from alpha1,3-galactosyltransferase gene-knockout pigs in baboons.
The American journal of pathology 2008;172(6):1471-81.
2008: Tonomura Noriko; Shimizu Akira; Wang Shumei; Yamada Kazuhiko; Tchipashvili Vaja; Weir Gordon C; Yang Yong-Guang
Pig islet xenograft rejection in a mouse model with an established human immune system.
Xenotransplantation 2008;15(2):129-35.
2008: Okumi Masayoshi; Fishbein Jonathan M; Griesemer Adam D; Gianello Pierre R; Hirakata Atsushi; Nobori Shuji; Moran Shannon; Samelson-Jones Emma; Shimizu Akira; Sachs David H; Yamada Kazuhiko
Role of persistence of antigen and indirect recognition in the maintenance of tolerance to renal allografts.
Transplantation 2008;85(2):270-80.
2007: Sachs David H; Yamada Kazuhiko; Robson Simon C; Fishman Jay A; Shimizu Akira; Colvin Robert B; Sykes Megan
GalT-KO pigs: is the cup half empty or half full?
Transplantation 2007;84(1):12-4.
2007: Vallabhajosyula Prashanth; Griesemer Adam; Yamada Kazuhiko; Sachs David H
Vascularized composite islet-kidney transplantation in a miniature swine model.
Cell biochemistry and biophysics 2007;48(2-3):201-7.
2006: Horner B M; Cina R A; Wikiel K J; Lima B; Ghazi A; Lo D P; Yamada K; Sachs D H; Huang C A
Predictors of organ allograft tolerance following hematopoietic cell transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2006;6(12):2894-902.
2006: Nobori Shuji; Shimizu Akira; Okumi Masayoshi; Samelson-Jones Emma; Griesemer Adam; Hirakata Atsushi; Sachs David H; Yamada Kazuhiko
Thymic rejuvenation and the induction of tolerance by adult thymic grafts.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(50):19081-6.
2006: Wong Banny S; Yamada Kazuhiko; Okumi Masayoshi; Weiner Joshua; O'Malley Patricia E; Tseng Yau-Lin; Dor Frank J M F; Cooper David K C; Saidman Susan L; Griesemer Adam; Sachs David H
Allosensitization does not increase the risk of xenoreactivity to alpha1,3-galactosyltransferase gene-knockout miniature swine in patients on transplantation waiting lists.
Transplantation 2006;82(3):314-9.
2006: Yamamoto Shin; Teranishi Katsuhito; Kamano Chisako; Samelson-Jones Emma; Arakawa Hitoshi; Nobori Shuji; Okumi Masayoshi; Houser Stuart; Shimizu Akira; Sachs David H; Yamada Kazuhiko
Role of the thymus in transplantation tolerance in miniature swine: V. Deficiency of the graft-to-thymus pathway of tolerance induction in recipients of cardiac transplants.
Transplantation 2006;81(4):607-13.
2006: Nobori Shuji; Samelson-Jones Emma; Shimizu Akira; Hisashi Yosuke; Yamamoto Shin; Kamano Chisako; Teranishi Katsuhito; Vagefi Parsia A; Nuhn Mathew; Okumi Masayoshi; Wong Banny; Houser Stuart; Sachs David H; Yamada Kazuhiko
Long-term acceptance of fully allogeneic cardiac grafts by cotransplantation of vascularized thymus in miniature swine.
Transplantation 2006;81(1):26-35.
2006: Shimizu Akira; Yamada Kazuhiko
Pathology of renal xenograft rejection in pig to non-human primate transplantation.
Clinical transplantation 2006;20 Suppl 15():46-52.
2005: Yamamoto Shin; Lavelle John M; Vagefi Parsia A; Arakawa Hitoshi; Samelson-Jones Emma; Moran Shannon; Teranishi Katsuhito; Kamano Chisako; Fishman Jay; Awwad Michel; Neville David M; Shimizu Akira; Sykes Megan; Sachs David H; Yamada Kazuhiko
Vascularized thymic lobe transplantation in a pig-to-baboon model: a novel strategy for xenogeneic tolerance induction and T-cell reconstitution.
Transplantation 2005;80(12):1783-90.
2005: Tseng Yau-Lin; Kuwaki Kenji; Dor Frank J M F; Shimizu Akira; Houser Stuart; Hisashi Yosuke; Yamada Kazuhiko; Robson Simon C; Awwad Michel; Schuurman Henk-Jan; Sachs David H; Cooper David K C
alpha1,3-Galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching 6 months.
Transplantation 2005;80(10):1493-500.
2005: Mathes David W; Solari Mario G; Randolph Mark A; Gazelle G Scott; Yamada Kazuhiko; Huang Christene A; Sachs David H; Lee W P Andrew
Long-term acceptance of renal allografts following prenatal inoculation with adult bone marrow.
Transplantation 2005;80(9):1300-8.
2005: Shimizu Akira; Yamada Kazuhiko; Yamamoto Shin; Lavelle John M; Barth Rolf N; Robson Simon C; Sachs David H; Colvin Robert B
Thrombotic microangiopathic glomerulopathy in human decay accelerating factor-transgenic swine-to-baboon kidney xenografts.
Journal of the American Society of Nephrology : JASN 2005;16(9):2732-45.
2005: Mezrich Joshua D; Benjamin Louis C; Sachs Jessica A; Houser Stuart L; Vagefi Parsia A; Sachs David H; Madsen Joren C; Yamada Kazuhiko
Role of the thymus and kidney graft in the maintenance of tolerance to heart grafts in miniature swine.
Transplantation 2005;79(12):1663-73.
2005: Dor F J M F; Kuwaki K; Tseng Y-L; Shimizu A; Houser S L; Yamada K; Hawley R J; Patience C; Awwad M; Fishman J A; Robson S C; Sachs D H; Schuurman H-J; Cooper D K C
Potential of aspirin to inhibit thrombotic microangiopathy in alpha1,3-galactosyltransferase gene-knockout pig hearts after transplantation in baboons.
Transplantation proceedings 2005;37(1):489-90.
2005: Kuwaki Kenji; Tseng Yau-Lin; Dor Frank J M F; Shimizu Akira; Houser Stuart L; Sanderson Todd M; Lancos Courtney J; Prabharasuth Derek D; Cheng Jane; Moran Kathleen; Hisashi Yosuke; Mueller Nicolas; Yamada Kazuhiko; Greenstein Julia L; Hawley Robert J; Patience Clive; Awwad Michel; Fishman Jay A; Robson Simon C; Schuurman Henk-Jan; Sachs David H; Cooper David K C
Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience.
Nature medicine 2005;11(1):29-31.
2005: Yamada Kazuhiko; Yazawa Koji; Shimizu Akira; Iwanaga Takehiro; Hisashi Yosuke; Nuhn Matthew; O'Malley Patricia; Nobori Shuji; Vagefi Parsia A; Patience Clive; Fishman Jay; Cooper David K C; Hawley Robert J; Greenstein Julia; Schuurman Henk-Jan; Awwad Michel; Sykes Megan; Sachs David H
Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue.
Nature medicine 2005;11(1):32-4.
2004: Dor Frank J M F; Tseng Yau-Lin; Cheng Jane; Moran Kathleen; Sanderson Todd M; Lancos Courtney J; Shimizu Akira; Yamada Kazuhiko; Awwad Michel; Sachs David H; Hawley Robert J; Schuurman Henk-Jan; Cooper David K C
alpha1,3-Galactosyltransferase gene-knockout miniature swine produce natural cytotoxic anti-Gal antibodies.
Transplantation 2004;78(1):15-20.
2004: Tseng Y-L; Dor F J M F; Kuwaki K; Ryan D; Wood J; Denaro M; Giovino M; Yamada K; Hawley R; Patience C; Schuurman H-J; Awwad M; Sachs D H; Cooper D K C
Bone marrow transplantation from alpha1,3-galactosyltransferase gene-knockout pigs in baboons.
Xenotransplantation 2004;11(4):361-70.
2004: Tomita Shinji; Ishida Michiko; Nakatani Takeshi; Fukuhara Shinya; Hisashi Yosuke; Ohtsu Yoshinori; Suga Michiharu; Yutani Chikao; Yagihara Toshikatsu; Yamada Kazuhiko; Kitamura Soichiro
Bone marrow is a source of regenerated cardiomyocytes in doxorubicin-induced cardiomyopathy and granulocyte colony-stimulating factor enhances migration of bone marrow cells and attenuates cardiotoxicity of doxorubicin under electron microscopy.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2004;23(5):577-84.
2004: Mezrich Josh; Yamada Kazuhiko; Sachs David H; Madsen Joren C
Regulatory T cells generated by the kidney may mediate the beneficial immune effects of combining kidney with heart transplantation.
Surgery 2004;135(5):473-8.
2004: Mueller Nicolas J; Livingston Christine; Knosalla Christoph; Barth Rolf N; Yamamoto Shin; Gollackner Bernd; Dor Frank J M F; Buhler Leo; Sachs David H; Yamada Kazuhiko; Cooper David K C; Fishman Jay A
Activation of porcine cytomegalovirus, but not porcine lymphotropic herpesvirus, in pig-to-baboon xenotransplantation.
The Journal of infectious diseases 2004;189(9):1628-33.
2004: Vagefi Parsia A; Ierino Francesco L; Gianello Pierre R; Shimizu Akira; Kamano Chisako; Sachs David H; Yamada Kazuhiko
Role of the thymus in transplantation tolerance in miniature Swine: IV. The thymus is required during the induction phase, but not the maintenance phase, of renal allograft tolerance.
Transplantation 2004;77(7):979-85.
2004: Kamano Chisako; Vagefi Parsia A; Kumagai Naoki; Yamamoto Shin; Barth Rolf N; LaMattina John C; Moran Shannon G; Sachs David H; Yamada Kazuhiko
Vascularized thymic lobe transplantation in miniature swine: thymopoiesis and tolerance induction across fully MHC-mismatched barriers.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(11):3827-32.
2004: Wu Anette; Yamada Kazuhiko; Baron Christophe; Mathes David W; Monajati Leila M; Vagefi Parsia A; Sachs David H
Detection of regulatory cells as an assay for allograft tolerance in miniature swine.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2004;23(2):210-7.
2004: Menard Matthew T; Schwarze Margaret L; Allan James S; Johnston Douglas R; Mawulawde Kwabena; Shimizu Akira; Yamada Kazuhiko; Houser Stuart L; Allison Kenneth S; Sachs David H; Madsen Joren C
Composite "thymoheart" transplantation improves cardiac allograft survival.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2004;4(1):79-86.
2003: Mezrich Joshua D; Kesselheim Jared A; Johnston Douglas R; Yamada Kazuhiko; Sachs David H; Madsen Joren C
The role of regulatory cells in miniature swine rendered tolerant to cardiac allografts by donor kidney cotransplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2003;3(9):1107-15.
2003: Mueller Nicolas J; Sulling Kristen; Gollackner Bernd; Yamamoto Shin; Knosalla Christoph; Wilkinson Robert A; Kaur Amitinder; Sachs David H; Yamada Kazuhiko; Cooper David K C; Patience Clive; Fishman Jay A
Reduced efficacy of ganciclovir against porcine and baboon cytomegalovirus in pig-to-baboon xenotransplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2003;3(9):1057-64.
2003: Mezrich Joshua D; Yamada Kazuhiko; Lee Richard S; Mawulawde Kwabena; Benjamin Louis C; Schwarze Margaret L; Maloney Michaella E; Amoah Hannah C; Houser Stuart L; Sachs David H; Madsen Joren C
Induction of tolerance to heart transplants by simultaneous cotransplantation of donor kidneys may depend on a radiation-sensitive renal-cell population.
Transplantation 2003;76(4):625-31.
2003: Yamada Kazuhiko; Vagefi Parsia A; Utsugi Ryu; Kitamura Hiroshi; Barth Rolf N; LaMattina John C; Sachs David H
Thymic transplantation in miniature swine: III. Induction of tolerance by transplantation of composite thymokidneys across fully major histocompatibility complex-mismatched barriers.
Transplantation 2003;76(3):530-6.
2003: Wu Anette; Yamada Kazuhiko; Ierino Francesco L; Vagefi Parsia A; Sachs David H
Regulatory mechanism of peripheral tolerance: in vitro evidence for dominant suppression of host responses during the maintenance phase of tolerance to renal allografts in miniature swine.
Transplant immunology 2003;11(3-4):367-74.
2003: Barth Rolf N; Yamamoto Shin; LaMattina John C; Kumagai Naoki; Kitamura Hiroshi; Vagefi Parsia A; Awwad Michel; Colvin Robert B; Cooper David K C; Sykes Megan; Sachs David H; Yamada Kazuhiko
Xenogeneic thymokidney and thymic tissue transplantation in a pig-to-baboon model: I. Evidence for pig-specific T-cell unresponsiveness.
Transplantation 2003;75(10):1615-24.
2003: Wu Anette; Yamada Kazuhiko; Neville David M; Awwad Michel; Wain John C; Shimizu Akira; Gojo Satoshi; Kitamura Hiroshi; Colvin Robert B; Cooper David K C; Sykes Megan; Sachs David H
Xenogeneic thymus transplantation in a pig-to-baboon model.
Transplantation 2003;75(3):282-91.
2002: Gleit Zachary L; Fuchimoto Yasushi; Yamada Kazuhiko; Melendy Elizabeth; Scheier-Dolberg Rachel; Monajati Leila; Coburn Rebecca C; Neville David M; Sachs David H; Huang Christene A
Variable relationship between chimerism and tolerance after hematopoietic cell transplantation without myelosuppressive conditioning.
Transplantation 2002;74(11):1535-44.
2002: Kumagai Naoki; O'Neil John J; Barth Rolf N; LaMattina John C; Utsugi Ryu; Moran Shannon G; Yamamoto Shin; Vagefi Parsia A; Kitamura Hiroshi; Kamano Chisako; Sachs David H; Yamada Kazuhiko
Vascularized islet-cell transplantation in miniature swine. I. Preparation of vascularized islet kidneys.
Transplantation 2002;74(9):1223-30.
2002: Kumagai Naoki; LaMattina John C; Kamano Chisako; Vagefi Parsia A; Barth Rolf N; O'Neil John J; Yamamoto Shin; Moran Shannon G; Utsugi Ryu; Sachs David H; Yamada Kazuhiko
Vascularized islet cell transplantation in miniature Swine: islet-kidney allografts correct the diabetic hyperglycemia induced by total pancreatectomy.
Diabetes 2002;51(11):3220-8.
2002: Shimizu Akira; Yamada Kazuhiko; Sachs David H; Colvin Robert B
Mechanisms of chronic renal allograft rejection. II. Progressive allograft glomerulopathy in miniature swine.
Laboratory investigation; a journal of technical methods and pathology 2002;82(6):673-86.
2002: Mueller Nicolas J; Barth Rolf N; Yamamoto Shin; Kitamura Hiroshi; Patience Clive; Yamada Kazuhiko; Cooper David K C; Sachs David H; Kaur Amitinder; Fishman Jay A
Activation of cytomegalovirus in pig-to-primate organ xenotransplantation.
Journal of virology 2002;76(10):4734-40.
2002: Shimizu Akira; Yamada Kazuhiko; Sachs David H; Colvin Robert B
Persistent rejection of peritubular capillaries and tubules is associated with progressive interstitial fibrosis.
Kidney international 2002;61(5):1867-79.
2002: LaMattina John C; Kumagai Naoki; Barth Rolf N; Yamamoto Shin; Kitamura Hiroshi; Moran Shannon G; Mezrich Joshua D; Sachs David H; Yamada Kazuhiko
Vascularized thymic lobe transplantation in miniature swine: I. Vascularized thymic lobe allografts support thymopoiesis.
Transplantation 2002;73(5):826-31.
2001: Bühler L; Yamada K; Kitamura H; Alwayn I P; Basker M; Appel J Z; Colvin R B; White-Scharf M E; Sachs D H; Robson S C; Awwad M; Cooper D K
Pig kidney transplantation in baboons: anti-Gal(alpha)1-3Gal IgM alone is associated with acute humoral xenograft rejection and disseminated intravascular coagulation.
Transplantation 2001;72(11):1743-52.
2001: Gargollo P; Yamada K; Esnaola N; Fuchimoto Y; Newell K L; Sachs D H; Huang C A
Neuropathy in miniature swine after administration of the mutant diphtheria toxin-based immunotoxin, pCD3-CRM9.
Transplantation 2001;72(5):818-22.
2001: Utsugi R; Barth R N; Lee R S; Kitamura H; LaMattina J C; Ambroz J; Sachs D H; Yamada K
Induction of transplantation tolerance with a short course of tacrolimus (FK506): I. Rapid and stable tolerance to two-haplotype fully mhc-mismatched kidney allografts in miniature swine.
Transplantation 2001;71(10):1368-79.
2001: Lee R S; Yamada K; Houser S L; Womer K L; Maloney M E; Rose H S; Sayegh M H; Madsen J C
Indirect recognition of allopeptides promotes the development of cardiac allograft vasculopathy.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3276-81.
2001: Wu A; Yamada K; Awwad M; Kitamura H; Wain J; Neville D M; Cooper D K; Sykes M; Sachs D H
Effects of xenogeneic thymic transplantation in baboons.
Transplantation proceedings 2001;33(1-2):766.
2001: Bühler L; Yamada K; Alwayn I; Kitamura H; Basker M; Barth R N; Appel J; Awwad M; Thall A; White-Scharf M E; Sachs D H; Cooper D K
Miniature swine and hDAF pig kidney transplantation in baboons treated with a nonmyeloablative regimen and CD154 blockade.
Transplantation proceedings 2001;33(1-2):716.
2001: Lee R S; Yamada K; Houser S L; Womer K L; Maloney M E; Rose H S; Sayegh M H; Madsen J C
Indirect allorecognition promotes the development of cardiac allograft vasculopathy.
Transplantation proceedings 2001;33(1-2):308-10.
2001: Utsugi R; Barth R N; Kitamura H; Ambroz J; Sachs D H; Yamada K
Tolerance across a two-haplotype, fully MHC-mismatched barrier induced in miniature swine renal allografts treated with a 12-day course of tacrolimus.
Transplantation proceedings 2001;33(1-2):101.
2001: Mathes D W; Yamada K; Randolph M A; Utsugi R; Solari M G; Gazelle G S; Wu A; Sachs D H; Lee W P
In utero induction of transplantation tolerance.
Transplantation proceedings 2001;33(1-2):98-100.
2001: Wu A; Ierino F L; Yamada K; Sachs D H
Specific suppression of proliferative responses by primed lymphocytes of tolerant miniature swine.
Transplantation proceedings 2001;33(1-2):87.
2001: Fuchimoto Y; Huang C A; Yamada K; Gleit Z L; Kitamura H; Griesemer A; Scheier-Dolberg R; Melendy E; White-Scharf M E; Sachs D H
Induction of kidney allograft tolerance through mixed chimerism in miniature swine.
Transplantation proceedings 2001;33(1-2):77.
2001: Sonntag K C; Emery D W; Yasumoto A; Haller G; Germana S; Sablinski T; Shimizu A; Yamada K; Shimada H; Arn S; Sachs D H; LeGuern C
Tolerance to solid organ transplants through transfer of MHC class II genes.
The Journal of clinical investigation 2001;107(1):65-71.
2000: Shimizu A; Yamada K; Sachs D H; Colvin R B
Intragraft events preceding chronic renal allograft rejection in a modified tolerance protocol.
Kidney international 2000;58(6):2546-58.
2000: Shimizu A; Yamada K; Meehan S M; Sachs D H; Colvin R B
Acceptance reaction: intragraft events associated with tolerance to renal allografts in miniature swine.
Journal of the American Society of Nephrology : JASN 2000;11(12):2371-80.
2000: Wu A; Yamada K; Awwad M; Shimizu A; Watts A; Murphy M; Gojo S; Neville D; Cooper D K; Sykes M; Sachs D H
Experience with porcine thymic transplantation in baboons.
Transplantation proceedings 2000;32(5):1048.
2000: Fuchimoto Y; Huang C A; Yamada K; Shimizu A; Kitamura H; Colvin R B; Ferrara V; Murphy M C; Sykes M; White-Scharf M; Neville D M; Sachs D H
Mixed chimerism and tolerance without whole body irradiation in a large animal model.
The Journal of clinical investigation 2000;105(12):1779-89.
2000: Yamada K; Mawulawde K; Menard M T; Shimizu A; Aretz H T; Choo J K; Allison K S; Slisz J K; Sachs D H; Madsen J C
Mechanisms of tolerance induction and prevention of cardiac allograft vasculopathy in miniature swine: the effect of augmentation of donor antigen load.
The Journal of thoracic and cardiovascular surgery 2000;119(4 Pt 1):709-19.
2000: Lee R S; Yamada K; Womer K L; Pillsbury E P; Allison K S; Marolewski A E; Geng D; Thall A D; Arn J S; Sachs D H; Sayegh M H; Madsen J C
Blockade of CD28-B7, but not CD40-CD154, prevents costimulation of allogeneic porcine and xenogeneic human anti-porcine T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(6):3434-44.
2000: Yamada K; Shimizu A; Utsugi R; Ierino F L; Gargollo P; Haller G W; Colvin R B; Sachs D H
Thymic transplantation in miniature swine. II. Induction of tolerance by transplantation of composite thymokidneys to thymectomized recipients.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(6):3079-86.
1999: Yamada K; Shimizu A; Ierino F L; Utsugi R; Barth R N; Esnaola N; Colvin R B; Sachs D H
Thymic transplantation in miniature swine. I. Development and function of the "thymokidney".
Transplantation 1999;68(11):1684-92.
1999: Haller G W; Esnaola N; Yamada K; Wu A; Shimizu A; Hansen A; Ferrara V R; Allison K S; Colvin R B; Sykes M; Sachs D H
Thymic transplantation across an MHC class I barrier in swine.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(7):3785-92.
1999: Huang C A; Yamada K; Murphy M C; Shimizu A; Colvin R B; Neville D M; Sachs D H
In vivo T cell depletion in miniature swine using the swine CD3 immunotoxin, pCD3-CRM9.
Transplantation 1999;68(6):855-60.
1999: Yamada K; Choo J K; Allan J S; Erhorn A E; Menard M T; Mawulawde K; Slisz J K; Aretz H T; Shimizu A; Sachs D H; Madsen J C
The effect of thymectomy on tolerance induction and cardiac allograft vasculopathy in a miniature swine heart/kidney transplantation model.
Transplantation 1999;68(4):485-91.
1999: Fuchimoto Y; Yamada K; Shimizu A; Yasumoto A; Sawada T; Huang C H; Sachs D H
Relationship between chimerism and tolerance in a kidney transplantation model.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(10):5704-11.
1999: Ierino F L; Gojo S; Banerjee P T; Giovino M; Xu Y; Gere J; Kaynor C; Awwad M; Monroy R; Rembert J; Hatch T; Foley A; Kozlowski T; Yamada K; Neethling F A; Fishman J; Bailin M; Spitzer T R; Cooper D K; Cosimi A B; LeGuern C; Sachs D H
Transfer of swine major histocompatibility complex class II genes into autologous bone marrow cells of baboons for the induction of tolerance across xenogeneic barriers.
Transplantation 1999;67(8):1119-28.
1999: Yamada K; Ierino F L; Gianello P R; Shimizu A; Colvin R B; Sachs D H
Role of the thymus in transplantation tolerance in miniature swine. III. Surgical manipulation of the thymus interferes with stable induction of tolerance to class I-mismatched renal allografts.
Transplantation 1999;67(8):1112-9.
1999: Yamada K; Shimizu A; Ierino F L; Gargollo P; Barth R; Colvin R B; Sachs D H
Allogeneic thymo-kidney transplants induce stable tolerance in miniature swine.
Transplantation proceedings 1999;31(1-2):1199-200.
1999: Wu A; Esnaola N F; Yamada K; Awwad M; Shimizu A; Huang C; Wain J; Zhao Y; Neville D M; Cooper D K; Sykes M; Sachs D H
Xenogeneic thymic transplantation in a pig-to-nonhuman primate model.
Transplantation proceedings 1999;31(1-2):957.
1999: Yamada K; Menard M T; Mawulawde K; Slisz J K; Choo J K; Erhorn A E; Sachs D H; Madsen J C
The effects of heart/kidney versus double heart transplantation on tolerance induction and prevention of cardiac allograft vasculopathy.
Transplantation proceedings 1999;31(1-2):108.
1999: Yamada K; Gianello P R; Ierino F L; Fishbein J; Lorf T; Shimizu A; Colvin R B; Sachs D H
Role of the thymus in transplantation tolerance in miniature swine: II. Effect of steroids and age on the induction of tolerance to class I mismatched renal allografts.
Transplantation 1999;67(3):458-67.
1999: Kozlowski T; Shimizu A; Lambrigts D; Yamada K; Fuchimoto Y; Glaser R; Monroy R; Xu Y; Awwad M; Colvin R B; Cosimi A B; Robson S C; Fishman J; Spitzer T R; Cooper D K; Sachs D H
Porcine kidney and heart transplantation in baboons undergoing a tolerance induction regimen and antibody adsorption.
Transplantation 1999;67(1):18-30.
1999: Ierino F L; Yamada K; Hatch T; Rembert J; Sachs D H
Peripheral tolerance to class I mismatched renal allografts in miniature swine: donor antigen-activated peripheral blood lymphocytes from tolerant swine inhibit antidonor CTL reactivity.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(1):550-9.
1998: Allan J S; Slisz J K; Vesga L; Arn J S; Yamada K; Sachs D H; Madsen J C
Enhanced efficacy of repeated anti-CD8 monoclonal antibody therapy by high-dose cyclosporine treatment.
Transplantation proceedings 1998;30(8):4062-3.
1998: Lambrigts D; Menard M T; Alexandre G P; Franssen C; Meurisse M; Van Calster P; Coignoul F; Mawulawde K; Choo J K; Yamada K; Erhorn A E; Slisz J K; Chiotellis P; Aretz H T; Sachs D H; Madsen J C
Creation of the "thymoheart" allograft: implantation of autologous thymus into the heart prior to procurement.
Transplantation 1998;66(6):810-4.
1998: Ierino F L; Yamada K; Lorf T; Arn J S; Sachs D H
Mechanism of tolerance to class I-mismatched renal allografts in miniature swine: regulation of interleukin-2 receptor alpha-chain expression on CD8 peripheral blood lymphocytes of tolerant animals.
Transplantation 1998;66(4):454-60.
1998: Madsen J C; Yamada K; Allan J S; Choo J K; Erhorn A E; Pins M R; Vesga L; Slisz J K; Sachs D H
Transplantation tolerance prevents cardiac allograft vasculopathy in major histocompatibility complex class I-disparate miniature swine.
Transplantation 1998;65(3):304-13.
1997: Yamada K; Gianello P R; Ierino F L; Lorf T; Shimizu A; Meehan S; Colvin R B; Sachs D H
Role of the thymus in transplantation tolerance in miniature swine. I. Requirement of the thymus for rapid and stable induction of tolerance to class I-mismatched renal allografts.
The Journal of experimental medicine 1997;186(4):497-506.
1997: Giangrande I; Yamada K; Arn S; Lorf T; Sachs D H; LeGuern C
Selective increase in CD4-positive graft-infiltrating mononuclear cells among the infiltrates in class I disparate kidney grafts undergoing rejection.
Transplantation 1997;63(5):722-8.
1997: Ierino F L; Yamada K; Hatch T; Sachs D H
Preliminary in vitro evidence for regulatory cells in a miniature swine renal allograft model.
Transplantation proceedings 1997;29(1-2):1165.
1997: Giangrande I; Yamada K; Germana S; Sachs D; LeGuern C
Tolerant cells infiltrating class I mismatched swine kidney allografts lack the CD4 single positive subset and down regulate TCR gene expression.
Transplantation proceedings 1997;29(1-2):1164.
1997: Shimizu A; Yamada K; Meehan S M; Sachs D H; Colvin R B
Intragraft cellular events associated with tolerance in pig allografts: the "acceptance reaction".
Transplantation proceedings 1997;29(1-2):1155.
1997: Yasumoto A; Yamada K; Sablinski T; LeGuern C; Sykes M; Sachs D H
Mechanism of tolerance following class II gene transduction of autologous swine bone marrow.
Transplantation proceedings 1997;29(1-2):1132.
1997: Yamada K; Gianello P R; Ierino F L; Shimizu A; Meehan S; Colvin R B; Sachs D H
Influence of the thymus on transplantation tolerance in miniature swine.
Transplantation proceedings 1997;29(1-2):1076.
1996: Yamada K; DerSimonian H; Sachs D H
The mechanism of xenogeneic cell-mediated lympholysis between human and pig cells.
Transplantation proceedings 1996;28(2):757.
1996: Gianello P R; Yamada K; Fishbein J M; Lorf T; Nickeleit V; Colvin R B; Arn J S; Sachs D H
Long-term acceptance of primarily vascularized renal allografts in miniature swine. Systemic tolerance versus graft adaptation.
Transplantation 1996;61(3):503-6.
1995: Yamada K; Sachs D H; DerSimonian H
Human anti-porcine xenogeneic T cell response. Evidence for allelic specificity of mixed leukocyte reaction and for both direct and indirect pathways of recognition.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(11):5249-56.
1995: Gianello P R; Lorf T; Yamada K; Fishbein J M; Nickeleit V; Vitiello D M; Sachs D H
Induction of tolerance to renal allografts across single-haplotype MHC disparities in miniature swine.
Transplantation 1995;59(6):884-90.
1995: Yamada K; Sachs D H; DerSimonian H
Direct and indirect recognition of pig class II antigens by human T cells.
Transplantation proceedings 1995;27(1):258-9.

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