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Haruyasu Yamaguchi

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Yohko Maki; Tomoharu Yamaguchi; Hiroshi Yoshida; Haruyasu Yamaguchi
Relative preservation of the recognition of positive facial expression "happiness" in Alzheimer disease.
Tomoharu Yamaguchi; Yohko Maki; Haruyasu Yamaguchi
Pitfall Intention Explanation Task with Clue Questions (Pitfall task): assessment of comprehending other people's behavioral intentions in Alzheimer's disease.
Tadahiko Kamegaya; Yohko Maki; Tatsuhiko Murai; Tetsuya Yamagami; Tomoharu Yamaguchi; Haruyasu Yamaguchi
Pleasant physical exercise program for prevention of cognitive decline in community-dwelling elderly with subjective memory complaints.

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2013: Yohko Maki; Tomoharu Yamaguchi; Hiroshi Yoshida; Haruyasu Yamaguchi
Relative preservation of the recognition of positive facial expression "happiness" in Alzheimer disease.
International psychogeriatrics / IPA 2013;25(1):105-10.
2012: Tomoharu Yamaguchi; Yohko Maki; Haruyasu Yamaguchi
Pitfall Intention Explanation Task with Clue Questions (Pitfall task): assessment of comprehending other people's behavioral intentions in Alzheimer's disease.
International psychogeriatrics / IPA 2012;24(12):1919-26.
2012: Tadahiko Kamegaya; Yohko Maki; Tatsuhiko Murai; Tetsuya Yamagami; Tomoharu Yamaguchi; Haruyasu Yamaguchi
Pleasant physical exercise program for prevention of cognitive decline in community-dwelling elderly with subjective memory complaints.
Geriatrics & gerontology international 2012;12(4):673-9.
2012: Yohko Maki; Ryutaro Takahashi; Chiaki Ura; Tomoharu Yamaguchi; Haruyasu Yamaguchi
Intervention using a community-based walking program is effective for elderly adults with depressive tendencies.
Journal of the American Geriatrics Society 2012;60(8):1590-1.
2012: Yohko Maki; Shutaro Nakaaki; Masakuni Amari; Tomoharu Yamaguchi; Haruyasu Yamaguchi
Anosognosia: patients' distress and self-awareness of deficits in Alzheimer's disease.
American journal of Alzheimer's disease and other dementias 2012;27(5):339-45.
2012: Yohko Maki; Fumiko Miyamae; Tatsuhiko Murai; Mika Sugiyama; Ryutaro Takahashi; Satoshi Tanaka; Chiaki Ura; Tetsuya Yamagami; Shuichi Awata; Mikie Isahai; Ayumi Kaiho; Tomoharu Yamaguchi; Haruyasu Yamaguchi
Effects of intervention using a community-based walking program for prevention of mental decline: a randomized controlled trial.
Journal of the American Geriatrics Society 2012;60(3):505-10.
2012: Dorothee Abramowski; Estibaliz Capetillo-Zarate; Simone Danner; Sabine Rabe; Julia Reichwald; Takaomi C Saido; Dieter Staab; Dietmar R Thal; Ajeet Rijal Upadhaya; Karl-Heinz Wiederhold; Haruyasu Yamaguchi; Matthias Staufenbiel
Transgenic expression of intraneuronal Aβ42 but not Aβ40 leads to cellular Aβ lesions, degeneration, and functional impairment without typical Alzheimer's disease pathology.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(4):1273-83.
2012: Tomoharu Yamaguchi; Yohko Maki; Haruyasu Yamaguchi
Yamaguchi Facial Expression-Making Task in Alzheimer's Disease: A Novel and Enjoyable Make-a-Face Game.
Dementia and geriatric cognitive disorders extra 2012;2(1):248-57.
2011: Haruyasu Yamaguchi; Yohko Maki
[Non-pharmacological therapy for dementia: an overview].
Nihon rinsho. Japanese journal of clinical medicine 2011;69 Suppl 10(Pt 2):98-103.
2011: Haruyasu Yamaguchi; Yohko Maki
[Dementia: progress in diagnosis and treatment; Topics, III. Treatments; 3. Non-pharmacological treatment of dementia].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2011;100(8):2146-52.
2010: Haruyasu Yamaguchi; Yohko Maki; Tetsuya Yamagami
Overview of non-pharmacological intervention for dementia and principles of brain-activating rehabilitation.
Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society 2010;10(4):206-13.
2010: Haruyasu Yamaguchi; Yohko Maki; Yohko Maki
Tube feeding can be discontinued by taking dopamine agonists and angiotensin-converting enzyme inhibitors in the advanced stages of dementia.
Journal of the American Geriatrics Society 2010;58(10):2035-6.
2010: Yohko Maki; Hiroshi Yoshida; Haruyasu Yamaguchi
Computerized visuo-spatial memory test as a supplementary screening test for dementia.
Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society 2010;10(2):77-82.
2010: Naoto Oikawa; Koichi Ogino; Takumi Masumoto; Haruyasu Yamaguchi; Katsuhiko Yanagisawa
Gender effect on the accumulation of hyperphosphorylated tau in the brain of locus-ceruleus-injured APP-transgenic mouse.
Neuroscience letters 2010;468(3):243-7.
2010: Haruyasu Yamaguchi; Yohko Maki; Tetsuya Yamagami
Yamaguchi fox-pigeon imitation test: a rapid test for dementia.
Dementia and geriatric cognitive disorders 2010;29(3):254-8.
2009: Naoto Oikawa; Haruyasu Yamaguchi; Koichi Ogino; Takao Taki; Kohei Yuyama; Naoki Yamamoto; Ryong-Woon Shin; Koichi Furukawa; Katsuhiko Yanagisawa
Gangliosides determine the amyloid pathology of Alzheimer's disease.
Neuroreport 2009;20(12):1043-6.
2009: Miho Oue; Kazuhiro Mitsumura; Takashi Torashima; Chiho Koyama; Haruyasu Yamaguchi; Nobuhiko Furuya; Hirokazu Hirai
Characterization of mutant mice that express polyglutamine in cerebellar Purkinje cells.
Brain research 2009;1255():9-17.
2009: Hideko Kokubo; Rakez Kayed; Charles G Glabe; Matthias Staufenbiel; Takaomi C Saido; Nobuhisa Iwata; Haruyasu Yamaguchi
Amyloid Beta annular protofibrils in cell processes and synapses accumulate with aging and Alzheimer-associated genetic modification.
International journal of Alzheimer's disease 2009;2009():.
2008: Takashi Torashima; Chiho Koyama; Akira Iizuka; Kazuhiro Mitsumura; Kiyohiko Takayama; Shigeru Yanagi; Miho Oue; Haruyasu Yamaguchi; Hirokazu Hirai
Lentivector-mediated rescue from cerebellar ataxia in a mouse model of spinocerebellar ataxia.
EMBO reports 2008;9(4):393-9.
2008: Cynthia A Lemere; Jiwon Oh; Heather A Stanish; Ying Peng; Imelda Pepivani; Anne M Fagan; Haruyasu Yamaguchi; Susan V Westmoreland; Keith G Mansfield
Cerebral amyloid-beta protein accumulation with aging in cotton-top tamarins: a model of early Alzheimer's disease?
Rejuvenation research 2008;11(2):321-32.
2007: Kun Zou; Haruyasu Yamaguchi; Hiroyasu Akatsu; Takaaki Sakamoto; Mihee Ko; Kazushige Mizoguchi; Jian-Sheng Gong; Wenxin Yu; Takayuki Yamamoto; Kenji Kosaka; Katsuhiko Yanagisawa; Makoto Michikawa
Angiotensin-converting enzyme converts amyloid beta-protein 1-42 (Abeta(1-42)) to Abeta(1-40), and its inhibition enhances brain Abeta deposition.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(32):8628-35.
2007: Dietmar R Thal; Sergey Larionov; Dorothee Abramowski; Karl-Heinz Wiederhold; Tom Van Dooren; Haruyasu Yamaguchi; Christian Haass; Fred Van Leuven; Matthias Staufenbiel; Estibaliz Capetillo-Zarate
Occurrence and co-localization of amyloid beta-protein and apolipoprotein E in perivascular drainage channels of wild-type and APP-transgenic mice.
Neurobiology of aging 2007;28(8):1221-30.
2006: Estibaliz Capetillo-Zarate; Matthias Staufenbiel; Dorothee Abramowski; Christian Haass; Angelika Escher; Christine Stadelmann; Haruyasu Yamaguchi; Otmar D Wiestler; Dietmar R Thal
Selective vulnerability of different types of commissural neurons for amyloid beta-protein-induced neurodegeneration in APP23 mice correlates with dendritic tree morphology.
Brain : a journal of neurology 2006;129(Pt 11):2992-3005.
2006: Shu-Ming Huang; Akihiro Mouri; Hideko Kokubo; Ryuichi Nakajima; Takahiro Suemoto; Makoto Higuchi; Matthias Staufenbiel; Yukihiro Noda; Haruyasu Yamaguchi; Toshitaka Nabeshima; Takaomi C Saido; Nobuhisa Iwata
Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function.
The Journal of biological chemistry 2006;281(26):17941-51.
2006: Satoru Kawai; Eiji Ikeda; Munehiro Sugiyama; Jun Matsumoto; Tetsuya Higuchi; Hong Zhang; Nasim Khan; Katsumi Tomiyoshi; Tomio Inoue; Haruyasu Yamaguchi; Ken Katakura; Keigo Endo; Hajime Matsuda; Mamoru Suzuki
Enhancement of splenic glucose metabolism during acute malarial infection: correlation of findings of FDG-PET imaging with pathological changes in a primate model of severe human malaria.
The American journal of tropical medicine and hygiene 2006;74(3):353-60.
2006: Fijs W B van Leeuwen; P van Tijn; M A F Sonnemans; Barbara Hobo; D M A Mann; Christine Van Broeckhoven; Samir Kumar-Singh; Patrick Cras; Geneviève Leuba; Armand Savioz; Marion L C Maat-Schieman; Haruyasu Yamaguchi; J M Kros; Wouter Kamphorst; Elly M Hol; Rob A I de Vos; David F Fischer
Frameshift proteins in autosomal dominant forms of Alzheimer disease and other tauopathies.
Neurology 2006;66(2 Suppl 1):S86-92.
2005: Haruyasu Yamaguchi
Illustration of dynamic changes in Alzheimer pathology: from mild cognitive impairment to terminal stage.
Neuropathology : official journal of the Japanese Society of Neuropathology 2005;25(4):285-7.
2005: Tomohiro Miyasaka; Zhen Ding; Keiko Gengyo-Ando; Miho Oue; Haruyasu Yamaguchi; Shohei Mitani; Yasuo Ihara
Progressive neurodegeneration in C. elegans model of tauopathy.
Neurobiology of disease 2005;20(2):372-83.
2005: Dietmar R Thal; Estibaliz Capetillo-Zarate; Christian Schultz; Udo Rüb; Takaomi C Saido; Haruyasu Yamaguchi; Christian Haass; W Sue T Griffin; Kelly Del Tredici; Heiko Braak; Estifanos Ghebremedhin
Apolipoprotein E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent manner.
Acta neuropathologica 2005;110(5):459-71.
2005: Naoki Yamamoto; Tatsuki Yokoseki; Masao Shibata; Haruyasu Yamaguchi; Katsuhiko Yanagisawa
Suppression of Abeta deposition in brain by peripheral administration of Fab fragments of anti-seed antibody.
Biochemical and biophysical research communications 2005;335(1):45-7.
2005: Hideko Kokubo; Rakez Kayed; Charles G Glabe; Takaomi C Saido; Nobuhisa Iwata; J Bernd Helms; Haruyasu Yamaguchi
Oligomeric proteins ultrastructurally localize to cell processes, especially to axon terminals with higher density, but not to lipid rafts in Tg2576 mouse brain.
Brain research 2005;1045(1-2):224-8.
2005: Naoki Yamamoto; Yoshio Hirabayashi; Masakuni Amari; Haruyasu Yamaguchi; Galina Romanov; William E Van Nostrand; Katsuhiko Yanagisawa
Assembly of hereditary amyloid beta-protein variants in the presence of favorable gangliosides.
FEBS letters 2005;579(10):2185-90.
2005: Hideko Kokubo; Takaomi C Saido; Nobuhisa Iwata; J Bernd Helms; Rumi Shinohara; Haruyasu Yamaguchi
Part of membrane-bound Abeta exists in rafts within senile plaques in Tg2576 mouse brain.
Neurobiology of aging 2005;26(4):409-18.
2005: Hideko Kokubo; Rakez Kayed; Charles G Glabe; Haruyasu Yamaguchi
Soluble Abeta oligomers ultrastructurally localize to cell processes and might be related to synaptic dysfunction in Alzheimer's disease brain.
Brain research 2005;1031(2):222-8.
2004: Yuko Horikoshi; Takashi Mori; Masahiro Maeda; Noriaki Kinoshita; Kumiko Sato; Haruyasu Yamaguchi
Abeta N-terminal-end specific antibody reduced beta-amyloid in Alzheimer-model mice.
Biochemical and biophysical research communications 2004;325(2):384-7.
2004: Munehiro Sugiyama; Eiji Ikeda; Satoru Kawai; Tetsuya Higuchi; Hong Zhang; Nasim Khan; Katsumi Tomiyoshi; Tomio Inoue; Haruyasu Yamaguchi; Ken Katakura; Keigo Endo; Mamoru Suzuki
Cerebral metabolic reduction in severe malaria: fluorodeoxyglucose-positron emission tomography imaging in a primate model of severe human malaria with cerebral involvement.
The American journal of tropical medicine and hygiene 2004;71(5):542-5.
2004: Atsushi Sasaki; Haruyasu Yamaguchi; Yuko Horikoshi; G Tanaka; Yoichi Nakazato
Expression of glucose transporter 5 by microglia in human gliomas.
Neuropathology and applied neurobiology 2004;30(5):447-55.
2004: Yuko Horikoshi; Gaku Sakaguchi; Amanda Becker; Audrey J Gray; karen duff; Paul S Aisen; Haruyasu Yamaguchi; Masahiro Maeda; Noriaki Kinoshita; Yasuji Matsuoka
Development of Abeta terminal end-specific antibodies and sensitive ELISA for Abeta variant.
Biochemical and biophysical research communications 2004;319(3):733-7.
2004: Hideki Hayashi; Nobuyuki Kimura; Haruyasu Yamaguchi; Kazuhiro Hasegawa; Tatsuki Yokoseki; Masao Shibata; Naoki Yamamoto; Makoto Michikawa; Yasuhiro Yoshikawa; Keiji Terao; Katsumi Matsuzaki; Cynthia A Lemere; Dennis J Selkoe; Hironobu Naiki; Katsuhiko Yanagisawa
A seed for Alzheimer amyloid in the brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(20):4894-902.
2004: Marion L C Maat-Schieman; Haruyasu Yamaguchi; Ingrid M Hegeman-Kleinn; Corrie Welling-Graafland; Remco Natté; Raymund A C Roos; Sjoerd G van Duinen
Glial reactions and the clearance of amyloid beta protein in the brains of patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type.
Acta neuropathologica 2004;107(5):389-98.
2004: Nao Taguchi; Toshimitsu Hatabu; Haruyasu Yamaguchi; Mamoru Suzuki; Kumiko Sato; Shigeyuki Kano
Plasmodium falciparum: selenium-induced cytotoxicity to P. falciparum.
Experimental parasitology 2004;106(1-2):50-5.
2003: Yoichi Araki; Susumu Tomita; Haruyasu Yamaguchi; Naomi Miyagi; Akio Sumioka; Yutaka Kirino; Toshiharu Suzuki
Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism.
The Journal of biological chemistry 2003;278(49):49448-58.
2003: Naoki Hashimoto; Tohru Takeuchi; Ryoko Ishihara; Katsuyuki Ukai; Hiroshi Kobayashi; Hiromu Iwata; Kiyoshi Iwai; Yutaka Mizuno; Haruyasu Yamaguchi; Hiroto Shibayama
Glial fibrillary tangles in diffuse neurofibrillary tangles with calcification.
Acta neuropathologica 2003;106(2):150-6.
2003: Takashi Kanamori; Kiyomi Nishimaki; Sadamitsu Asoh; Yoshitomo Ishibashi; Iichiro Takata; Tomoko Kuwabara; Kazunari Taira; Haruyasu Yamaguchi; Shiro Sugihara; Tsuneo Yamazaki; Yasuo Ihara; Kyoko Nakano; Sadayuki Matuda; Shigeo Ohta
Truncated product of the bifunctional DLST gene involved in biogenesis of the respiratory chain.
The EMBO journal 2003;22(12):2913-23.
2003: Jaime E Rofina; I van Andel; Anne Marie van Ederen; Nikolaos Papaioannou; Haruyasu Yamaguchi; Erik Gruys
Canine counterpart of senile dementia of the Alzheimer type: amyloid plaques near capillaries but lack of spatial relationship with activated microglia and macrophages.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2003;10(2):86-96.
2003: Hideko Kokubo; J Bernd Helms; Yoshiko Ohno-Iwashita; Yukiko Shimada; Yuko Horikoshi; Haruyasu Yamaguchi
Ultrastructural localization of flotillin-1 to cholesterol-rich membrane microdomains, rafts, in rat brain tissue.
Brain research 2003;965(1-2):83-90.
2003: Atsushi Sasaki; Yuko Horikoshi; Hideaki Yokoo; Yoichi Nakazato; Haruyasu Yamaguchi
Antiserum against human glucose transporter 5 is highly specific for microglia among cells of the mononuclear phagocyte system.
Neuroscience letters 2003;338(1):17-20.
2003: Yuko Horikoshi; Atsushi Sasaki; N Taguchi; Masahiro Maeda; H Tsukagoshi; Kumiko Sato; Haruyasu Yamaguchi
Human GLUT5 immunolabeling is useful for evaluating microglial status in neuropathological study using paraffin sections.
Acta neuropathologica 2003;105(2):157-62.
2002: Reisuke H Takahashi; Teresa A Milner; Feng Li; Ellen E Nam; Mark A Edgar; Haruyasu Yamaguchi; M Flint Beal; Huaxi Xu; Paul Greengard; Gunnar K Gouras
Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology.
The American journal of pathology 2002;161(5):1869-79.
2002: Xuefeng Xia; Pei Wang; Xiaoyan Sun; Salvador Soriano; Wan-Kyng Shum; Haruyasu Yamaguchi; Myrna E Trumbauer; Akihiko Takashima; Edward H Koo; Hui Zheng
The aspartate-257 of presenilin 1 is indispensable for mouse development and production of beta-amyloid peptides through beta-catenin-independent mechanisms.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(13):8760-5.
2002: Xiaorei Sai; Yuuki Kawamura; Koichi Kokame; Haruyasu Yamaguchi; Hirohisa Shiraishi; Ryo Suzuki; Toshiharu Suzuki; Masashi Kawaichi; Toshiyuki Miyata; Toshio Kitamura; Bart De Strooper; Katsuhiko Yanagisawa; Hiroto Komano
Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein.
The Journal of biological chemistry 2002;277(15):12915-20.
2002: X Sun; S Sato; O Murayama; M Murayama; J-M Park; Haruyasu Yamaguchi; A Takashima
Lithium inhibits amyloid secretion in COS7 cells transfected with amyloid precursor protein C100.
Neuroscience letters 2002;321(1-2):61-4.
2002: Dietmar R Thal; Estifanos Ghebremedhin; Udo Rüb; Haruyasu Yamaguchi; Kelly Del Tredici; Heiko Braak
Two types of sporadic cerebral amyloid angiopathy.
Journal of neuropathology and experimental neurology 2002;61(3):282-93.
2002: Xiaoyan Sun; Gregory M. Cole; Teresa Chu; Weiming Xia; Douglas Galasko; Haruyasu Yamaguchi; Kentaro Tanemura; Sally A Frautschy; Akihiko Takashima
Intracellular Abeta is increased by okadaic acid exposure in transfected neuronal and non-neuronal cell lines.
Neurobiology of aging 2002;23(2):195-203.
2002: Kentaro Tanemura; Miyuki Murayama; Takumi Akagi; Tsutomu Hashikawa; Takashi Tominaga; Michinori Ichikawa; Haruyasu Yamaguchi; Akihiko Takashima
Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(1):133-41.
2001: Kentaro Tanemura; Takumi Akagi; Miyuki Murayama; N Kikuchi; Ohoshi Murayama; Tsutomu Hashikawa; Y Yoshiike; J M Park; K Matsuda; S Nakao; Xiaoyan Sun; Shinji Sato; Haruyasu Yamaguchi; Akihiko Takashima
Formation of filamentous tau aggregations in transgenic mice expressing V337M human tau.
Neurobiology of disease 2001;8(6):1036-45.
2001: Haruyasu Yamaguchi; S Sugihara; A Ogawa; N Oshima; Yasuo Ihara
Alzheimer beta amyloid deposition enhanced by apoE epsilon4 gene precedes neurofibrillary pathology in the frontal association cortex of nondemented senior subjects.
Journal of neuropathology and experimental neurology 2001;60(7):731-9.
2001: Nagahisa Oshima; Maho Morishima-Kawashima; Haruyasu Yamaguchi; M Yoshimura; S Sugihara; K Khan; Dora Games; Dale Schenk; Yasuo Ihara
Accumulation of amyloid beta-protein in the low-density membrane domain accurately reflects the extent of beta-amyloid deposition in the brain.
The American journal of pathology 2001;158(6):2209-18.
2000: Maho Morishima-Kawashima; Nagahisa Oshima; H Ogata; Haruyasu Yamaguchi; M Yoshimura; S Sugihara; Yasuo Ihara
Effect of apolipoprotein E allele epsilon4 on the initial phase of amyloid beta-protein accumulation in the human brain.
The American journal of pathology 2000;157(6):2093-9.
2000: Dietmar R Thal; Christian Schultz; Faramarz Dehghani; Haruyasu Yamaguchi; Heiko Braak; Eva Braak
Amyloid beta-protein (Abeta)-containing astrocytes are located preferentially near N-terminal-truncated Abeta deposits in the human entorhinal cortex.
Acta neuropathologica 2000;100(6):608-17.
2000: Hideko Kokubo; Cynthia A Lemere; Haruyasu Yamaguchi
Localization of flotillins in human brain and their accumulation with the progression of Alzheimer's disease pathology.
Neuroscience letters 2000;290(2):93-6.
2000: Haruyasu Yamaguchi; Marion L C Maat-Schieman; Sjoerd G van Duinen; Frans A Prins; P Neeskens; Remco Natté; Raymund A C Roos
Amyloid beta protein (Abeta) starts to deposit as plasma membrane-bound form in diffuse plaques of brains from hereditary cerebral hemorrhage with amyloidosis-Dutch type, Alzheimer disease and nondemented aged subjects.
Journal of neuropathology and experimental neurology 2000;59(8):723-32.
2000: M Oue; Haruyasu Yamaguchi; Kumiko Sato; Mamoru Suzuki
Immunohistochemical localization of acid proteinase in Ascaris suum adult worm.
Experimental parasitology 2000;95(2):144-7.
2000: Marion L C Maat-Schieman; Haruyasu Yamaguchi; Sjoerd G van Duinen; Remco Natté; Raymund A C Roos
Age-related plaque morphology and C-terminal heterogeneity of amyloid beta in Dutch-type hereditary cerebral hemorrhage with amyloidosis.
Acta neuropathologica 2000;99(4):409-19.
2000: K Tsuzuki; R Fukatsu; Haruyasu Yamaguchi; M Tateno; K Imai; Nobuhiro Fujii; T Yamauchi
Transthyretin binds amyloid beta peptides, Abeta1-42 and Abeta1-40 to form complex in the autopsied human kidney - possible role of transthyretin for abeta sequestration.
Neuroscience letters 2000;281(2-3):171-4.
2000: I Fakla; I Kovacs; Haruyasu Yamaguchi; Changiz Geula; Péter Kása
Expressions of amyloid precursor protein, synaptophysin and presenilin-1 in the different areas of the developing cerebellum of rat.
Neurochemistry international 2000;36(2):143-51.
2000: Péter Kása; Henrietta Papp; I Kovacs; M Forgon; Botond Penke; Haruyasu Yamaguchi
Human amyloid-beta1-42 applied in vivo inhibits the fast axonal transport of proteins in the sciatic nerve of rat.
Neuroscience letters 2000;278(1-2):117-9.
1999: Remco Natté; Haruyasu Yamaguchi; Marion L C Maat-Schieman; Frans A Prins; P Neeskens; Raymund A C Roos; Sjoerd G van Duinen
Ultrastructural evidence of early non-fibrillar Abeta42 in the capillary basement membrane of patients with hereditary cerebral hemorrhage with amyloidosis, Dutch type.
Acta neuropathologica 1999;98(6):577-82.
1999: K Ishiguro; H Ohno; Hiroyuki Arai; Haruyasu Yamaguchi; Katsuya Urakami; J M Park; K Sato; H Kohno; K Imahori
Phosphorylated tau in human cerebrospinal fluid is a diagnostic marker for Alzheimer's disease.
Neuroscience letters 1999;270(2):91-4.
1999: M Enya; Maho Morishima-Kawashima; M Yoshimura; Y Shinkai; K Kusui; K Khan; Dora Games; Dale Schenk; S Sugihara; Haruyasu Yamaguchi; Yasuo Ihara
Appearance of sodium dodecyl sulfate-stable amyloid beta-protein (Abeta) dimer in the cortex during aging.
The American journal of pathology 1999;154(1):271-9.
1998: Akihiko Takashima; Miyuki Murayama; Ohoshi Murayama; T Kohno; T Honda; K Yasutake; N Nihonmatsu; M Mercken; Haruyasu Yamaguchi; S Sugihara; Benjamin Wolozin
Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(16):9637-41.
1998: Akihiko Takashima; T Honda; K Yasutake; G Michel; Ohoshi Murayama; Miyuki Murayama; K Ishiguro; Haruyasu Yamaguchi
Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons.
Neuroscience research 1998;31(4):317-23.
1998: Yorihide Hayashi; R Fukatsu; K Tsuzuki; Taku Yoshida; Nobuyuki Sasaki; K Kimura; Haruyasu Yamaguchi; Peter St George-Hyslop; Nobuhiro Fujii; N Takahata
Evidence for presenilin-1 involvement in amyloid angiopathy in the Alzheimer's disease-affected brain.
Brain research 1998;789(2):307-14.
1998: Haruyasu Yamaguchi; S Sugihara; A Ogawa; Takaomi C Saido; Yasuo Ihara
Diffuse plaques associated with astroglial amyloid beta protein, possibly showing a disappearing stage of senile plaques.
Acta neuropathologica 1998;95(3):217-22.
1998: K Imahori; M Hoshi; K Ishiguro; K Sato; M Takahashi; R Shiurba; Haruyasu Yamaguchi; Akihiko Takashima; T Uchida
Possible role of tau protein kinases in pathogenesis of Alzheimer's disease.
Neurobiology of aging 1998;19(1 Suppl):S93-8.
1997: Atsushi Sasaki; Haruyasu Yamaguchi; A Ogawa; S Sugihara; Yoichi Nakazato
Microglial activation in early stages of amyloid beta protein deposition.
Acta neuropathologica 1997;94(4):316-22.
1997: K Tsuzuki; R Fukatsu; Yorihide Hayashi; Taku Yoshida; Nobuyuki Sasaki; Y Takamaru; Haruyasu Yamaguchi; M Tateno; Nobuhiro Fujii; N Takahata
Amyloid beta protein and transthyretin, sequestrating protein colocalize in normal human kidney.
Neuroscience letters 1997;222(3):163-6.
1996: Haruyasu Yamaguchi
[Alzheimer's disease and apolipoprotein E].
Nō to shinkei = Brain and nerve 1996;48(11):981-90.
1996: Cynthia A Lemere; Francisco Lopera; Kenneth S Kosik; Corinne Lendon; Jorge E Ossa; Takaomi C Saido; Haruyasu Yamaguchi; A Ruiz; A Martinez; L Madrigal; L Hincapie; JC Arango; D C Anthony; Edward H Koo; Alison Goate; Dennis J Selkoe; J C Arango
The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology.
Nature medicine 1996;2(10):1146-50.
1996: Haruyasu Yamaguchi; Koichi Ishiguro; T Uchida; A Takashima; Cynthia A Lemere; K Imahori
Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3 beta and cyclin-dependent kinase 5, a component of TPK II.
Acta neuropathologica 1996;92(3):232-41.
1996: Cynthia A Lemere; J K Blusztajn; Haruyasu Yamaguchi; Thomas Wisniewski; Takaomi C Saido; Dennis J Selkoe
Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.
Neurobiology of disease 1996;3(1):16-32.
1995: K Tsuzuki; R Fukatsu; Y Takamaru; Taku Yoshida; Yorihide Hayashi; Haruyasu Yamaguchi; N Fujii; N Takahata
Amyloid beta protein in rat soleus muscle in chloroquine-induced myopathy using end-specific antibodies for A beta 40 and A beta 42: immunohistochemical evidence for amyloid beta protein.
Neuroscience letters 1995;202(1-2):77-80.
1995: Akihiko Takashima; Haruyasu Yamaguchi; K Noguchi; G Michel; K Ishiguro; K Sato; T Hoshino; M Hoshi; K Imahori
Amyloid beta peptide induces cytoplasmic accumulation of amyloid protein precursor via tau protein kinase I/glycogen synthase kinase-3 beta in rat hippocampal neurons.
Neuroscience letters 1995;198(2):83-6.
1995: S Sugihara; A Ogawa; Y Nakazato; Haruyasu Yamaguchi
Cerebral beta amyloid deposition in patients with malignant neoplasms: its prevalence with aging and effects of radiation therapy on vascular amyloid.
Acta neuropathologica 1995;90(2):135-41.
1994: Haruyasu Yamaguchi; T Yamazaki; Takeshi Kawarabayashi; X Sun; Y Sakai; Shunsaku Hirai
Localization of Alzheimer amyloid beta protein precursor and its relation to senile plaque amyloid.
Gerontology 1994;40 Suppl 2():65-70.
1994: Haruyasu Yamaguchi; Koichi Ishiguro; S Sugihara; Yoichi Nakazato; Takeshi Kawarabayashi; X Sun; Shunsaku Hirai
Presence of apolipoprotein E on extracellular neurofibrillary tangles and on meningeal blood vessels precedes the Alzheimer beta-amyloid deposition.
Acta neuropathologica 1994;88(5):413-9.
1993: Takeshi Kawarabayashi; Mikio Shoji; Haruyasu Yamaguchi; Makoto Tanaka; Yasuo Harigaya; Koichi Ishiguro; Shunsaku Hirai
Amyloid beta protein precursor accumulates in swollen neurites throughout rat brain with aging.
Neuroscience letters 1993;153(1):73-6.
1993: Masaki Ikeda; Mikio Shoji; Haruyasu Yamaguchi; E Matsubara; Masakuni Amari; Koichi Ishiguro; Takeshi Kawarabayashi; Yasuo Harigaya; Shunsaku Hirai
Diagnostic significance of skin immunolabelling with antibody against native cerebral amyloid in Alzheimer's disease.
Neuroscience letters 1993;150(2):159-61.
1993: Koichi Ishiguro; Mikio Shoji; Haruyasu Yamaguchi; E Matsubara; Masaki Ikeda; Takeshi Kawarabayashi; Yasuo Harigaya; K Okamoto; Shunsaku Hirai
Differential expression of alpha 1-antichymotrypsin in the aged human brain.
Virchows Archiv. B, Cell pathology including molecular pathology 1993;64(4):221-7.
1993: T Yamazaki; Haruyasu Yamaguchi; Takeshi Kawarabayashi; Shunsaku Hirai
Ultrastructural localization of amyloid beta/A4 protein precursor in the normal rat brain.
Virchows Archiv. B, Cell pathology including molecular pathology 1993;63(3):173-80.
1992: M Imagawa; S Naruse; S Tsuji; A Fujioka; Haruyasu Yamaguchi
Coenzyme Q10, iron, and vitamin B6 in genetically-confirmed Alzheimer's disease.
Lancet 1992;340(8820):671.
1992: Haruyasu Yamaguchi; T Yamazaki; Cynthia A Lemere; M P Frosch; Dennis J Selkoe
Beta amyloid is focally deposited within the outer basement membrane in the amyloid angiopathy of Alzheimer's disease. An immunoelectron microscopic study.
The American journal of pathology 1992;141(1):249-59.
1992: T Yamazaki; Haruyasu Yamaguchi; Yoichi Nakazato; Koichi Ishiguro; Takeshi Kawarabayashi; Shunsaku Hirai
Ultrastructural characterization of cerebellar diffuse plaques in Alzheimer's disease.
Journal of neuropathology and experimental neurology 1992;51(3):281-6.
1992: Haruyasu Yamaguchi; T Yamazaki; Koichi Ishiguro; Mikio Shoji; Yoichi Nakazato; Shunsaku Hirai
Ultrastructural localization of Alzheimer amyloid beta/A4 protein precursor in the cytoplasm of neurons and senile plaque-associated astrocytes.
Acta neuropathologica 1992;85(1):15-22.
1991: Takeshi Kawarabayashi; Mikio Shoji; Y Harigaya; Haruyasu Yamaguchi; Shunsaku Hirai
Expression of APP in the early stage of brain damage.
Brain research 1991;563(1-2):334-8.
1991: Takeshi Kawarabayashi; Mikio Shoji; Y Harigaya; Haruyasu Yamaguchi; Shunsaku Hirai
Amyloid beta/A4 protein precursor is widely distributed in both the central and peripheral nervous systems of the mouse.
Brain research 1991;552(1):1-7.
1991: Haruyasu Yamaguchi; Yoichi Nakazato; Mikio Shoji; K Okamoto; Yasuo Ihara; M Morimatsu; Shunsaku Hirai
Secondary deposition of beta amyloid within extracellular neurofibrillary tangles in Alzheimer-type dementia.
The American journal of pathology 1991;138(3):699-705.
1991: Haruyasu Yamaguchi; Yoichi Nakazato; T Yamazaki; Mikio Shoji; Takeshi Kawarabayashi; Shunsaku Hirai
Subpial beta/A4 amyloid deposition occurs between astroglial processes in Alzheimer-type dementia.
Neuroscience letters 1991;123(2):217-20.
1991: Haruyasu Yamaguchi; Yoichi Nakazato; Mikio Shoji; M Takatama; Shunsaku Hirai
Ultrastructure of diffuse plaques in senile dementia of the Alzheimer type: comparison with primitive plaques.
Acta neuropathologica 1991;82(1):13-20.
1991: Haruyasu Yamaguchi; Yoichi Nakazato; Takeshi Kawarabayashi; Koichi Ishiguro; Yasuo Ihara; M Morimatsu; Shunsaku Hirai
Extracellular neurofibrillary tangles associated with degenerating neurites and neuropil threads in Alzheimer-type dementia.
Acta neuropathologica 1991;81(6):603-9.
1991: A Sasaki; Y Nakanishi; Y Nakazato; Haruyasu Yamaguchi
Application of lectin and B-lymphocyte-specific monoclonal antibodies for the demonstration of human microglia in formalin-fixed, paraffin-embedded brain tissue.
Virchows Archiv. A, Pathological anatomy and histopathology 1991;419(4):291-9.
1991: T Yamazaki; Haruyasu Yamaguchi; K Okamoto; Shunsaku Hirai
Ultrastructural localization of argyrophilic substances in diffuse plaques of Alzheimer-type dementia demonstrated by methenamine silver staining.
Acta neuropathologica 1991;81(5):540-5.
1991: Mikio Shoji; Shunsaku Hirai; Haruyasu Yamaguchi; Yasuo Harigaya; Koichi Ishiguro; E Matsubara
Alpha 1-antichymotrypsin is present in diffuse senile plaques. A comparative study of beta-protein and alpha 1-antichymotrypsin immunostaining in the Alzheimer brain.
The American journal of pathology 1991;138(1):247-57.
1990: Haruyasu Yamaguchi; Koichi Ishiguro; Mikio Shoji; T Yamazaki; Yoichi Nakazato; Yasuo Ihara; Shunsaku Hirai
Amyloid beta/A4 protein precursor is bound to neurofibrillary tangles in Alzheimer-type dementia.
Brain research 1990;537(1-2):318-22.
1990: Mikio Shoji; Takeshi Kawarabayashi; Yasuo Harigaya; Haruyasu Yamaguchi; Shunsaku Hirai; T Kamimura; T Sugiyama
Alzheimer amyloid beta-protein precursor in sperm development.
The American journal of pathology 1990;137(5):1027-32.
1990: Mikio Shoji; Shunsaku Hirai; Y Harigaya; Takeshi Kawarabayashi; Haruyasu Yamaguchi
The amyloid beta-protein precursor is localized in smooth muscle cells of leptomeningeal vessels.
Brain research 1990;530(1):113-6.
1990: E Matsubara; Shunsaku Hirai; Masakuni Amari; Mikio Shoji; Haruyasu Yamaguchi; K Okamoto; Koichi Ishiguro; Yasuo Harigaya; K Wakabayashi
Alpha 1-antichymotrypsin as a possible biochemical marker for Alzheimer-type dementia.
Annals of neurology 1990;28(4):561-7.
1990: A Sotomatsu; Makoto Tanaka; Haruyasu Yamaguchi; K Okamoto; Shunsaku Hirai
[Systemic lupus erythematosus presenting chronic relapsing polyneuropathy as the first manifestation without auto-antibodies].
Rinshō shinkeigaku = Clinical neurology 1990;30(9):985-8.
1990: Yoichi Nakazato; H Yamazaki; Junko Hirato; Y Ishida; Haruyasu Yamaguchi
Oligodendroglial microtubular tangles in olivopontocerebellar atrophy.
Journal of neuropathology and experimental neurology 1990;49(5):521-30.
1990: Mikio Shoji; Shunsaku Hirai; Haruyasu Yamaguchi; Y Harigaya; Takeshi Kawarabayashi
Amyloid beta-protein precursor accumulates in dystrophic neurites of senile plaques in Alzheimer-type dementia.
Brain research 1990;512(1):164-8.
1990: Haruyasu Yamaguchi; Yoichi Nakazato; Shunsaku Hirai; Mikio Shoji
Immunoelectron microscopic localization of amyloid beta protein in the diffuse plaques of Alzheimer-type dementia.
Brain research 1990;508(2):320-4.
1990: Haruyasu Yamaguchi; Yoichi Nakazato; Mikio Shoji; Yasuo Ihara; Shunsaku Hirai
Ultrastructure of the neuropil threads in the Alzheimer brain: their dendritic origin and accumulation in the senile plaques.
Acta neuropathologica 1990;80(4):368-74.
1990: Haruyasu Yamaguchi; C Haga; Shunsaku Hirai; Yoichi Nakazato; Kenji Kosaka
Distinctive, rapid, and easy labeling of diffuse plaques in the Alzheimer brains by a new methenamine silver stain.
Acta neuropathologica 1990;79(5):569-72.
1989: Haruyasu Yamaguchi; Yoichi Nakazato; Shunsaku Hirai; Mikio Shoji; Yasuo Harigaya
Electron micrograph of diffuse plaques. Initial stage of senile plaque formation in the Alzheimer brain.
The American journal of pathology 1989;135(4):593-7.
1989: K Okamoto; Haruyasu Yamaguchi; Shunsaku Hirai; Mikio Shoji; K Inoue; M Takatama
Immunogold electron microscopic study of cerebrovascular and senile plaque amyloid using anti-beta protein antibody.
Progress in clinical and biological research 1989;317():953-63.
1989: E Matsubara; Masakuni Amari; Mikio Shoji; Yasuo Harigaya; Haruyasu Yamaguchi; K Okamoto; Shunsaku Hirai
Serum concentration of alpha 1-antichymotrypsin is elevated in patients with senile dementia of the Alzheimer type.
Progress in clinical and biological research 1989;317():707-14.
1989: Mikio Shoji; Yasuo Harigaya; Haruyasu Yamaguchi; K Okamoto; Shunsaku Hirai; M Takatama
Immunocytochemical study of alpha 1-antichymotrypsin in the senescent cerebral amyloid.
Progress in clinical and biological research 1989;317():1049-59.
1989: Mikio Shoji; Y Harigaya; Haruyasu Yamaguchi; K Okamoto; Shunsaku Hirai
[An immunocytochemical study of alpha 1-antichymotrypsin in the senescent cerebral amyloid].
Rinshō shinkeigaku = Clinical neurology 1989;29(1):30-9.
1989: Yasuo Harigaya; Mikio Shoji; Haruyasu Yamaguchi; Shunsaku Hirai; M Takatama
A study of beta protein precursor using antiserum against a synthetic peptide (1-28).
Progress in clinical and biological research 1989;317():945-52.
1989: Haruyasu Yamaguchi; Shunsaku Hirai; Mikio Shoji; Yasuo Harigaya; Y Okamoto; Y Nakazato
Alzheimer type dementia: diffuse type of senile plaques demonstrated by beta protein immunostaining.
Progress in clinical and biological research 1989;317():467-74.
1989: Haruyasu Yamaguchi; Shunsaku Hirai; M Morimatsu; Mikio Shoji; Yoichi Nakazato
Diffuse type of senile plaques in the cerebellum of Alzheimer-type dementia demonstrated by beta protein immunostain.
Acta neuropathologica 1989;77(3):314-9.
1988: Haruyasu Yamaguchi; Shunsaku Hirai; M Momimatsu; Yasuo Ihara
[A comparative study on the ability to stain senile plaques with beta protein immunostain and three kinds of silver impregnation methods].
Rinshō shinkeigaku = Clinical neurology 1988;28(6):688-94.
1988: Haruyasu Yamaguchi; Shunsaku Hirai; M Morimatsu; Mikio Shoji; Yasuo Ihara
A variety of cerebral amyloid deposits in the brains of the Alzheimer-type dementia demonstrated by beta protein immunostaining.
Acta neuropathologica 1988;76(6):541-9.
1988: Haruyasu Yamaguchi; Shunsaku Hirai; M Morimatsu; Mikio Shoji; Y Harigaya
Diffuse type of senile plaques in the brains of Alzheimer-type dementia.
Acta neuropathologica 1988;77(2):113-9.
1988: Mikio Shoji; Y Harigaya; K Okamoto; Haruyasu Yamaguchi; Shunsaku Hirai
[The study of neuroactive substance within senile plaques--with special reference to somatostatin and substance P].
Rinshō shinkeigaku = Clinical neurology 1988;28(1):67-73.
1987: Haruyasu Yamaguchi; K Okamoto; M Shooji; M Morimatsu; Shunsaku Hirai
Muscle histology of hypocalcaemic myopathy in hypoparathyroidism.
Journal of neurology, neurosurgery, and psychiatry 1987;50(6):817-8.
1987: Haruyasu Yamaguchi; M Morimatsu; K Okamoto; Shunsaku Hirai
[Senile dementia of Alzheimer type--relation between types of senile plaques and dementia].
Rinshō shinkeigaku = Clinical neurology 1987;27(5):617-21.
1987: Haruyasu Yamaguchi; M Morimatsu; Shunsaku Hirai; K Takahashi
Alzheimer's neurofibrillary tangles are penetrated by astroglial processes and appear eosinophilic in their final stages.
Acta neuropathologica 1987;72(3):214-7.
1984: K Okamoto; T Yamazaki; Haruyasu Yamaguchi; M Morimatsu; Shunsaku Hirai
[An autopsy case of diffuse Lewy body disease].
Rinshō shinkeigaku = Clinical neurology 1984;24(10):975-83.
1983: Haruyasu Yamaguchi; K Okamoto; M Shooji; M Morimatsu; S Hirai
[A case of adult type sialidosis with partial beta-galactosidase deficiency without myoclonus].
Rinshō shinkeigaku = Clinical neurology 1983;23(1):1-8.
1982: K Okamoto; Asao Hirano; Haruyasu Yamaguchi; Shunsaku Hirai
[The fine structure of eosinophilic stages of Alzheimer's neurofibrillary tangles].
Rinshō shinkeigaku = Clinical neurology 1982;22(9):840-6.