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Haruyasu Yamaguchi

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Oikawa Naoto; Yamaguchi Haruyasu; Ogino Koichi; Taki Takao; Yuyama Kohei; Yamamoto Naoki; Shin Ryong-Woon; Furukawa Koichi; Yanagisawa Katsuhiko
Gangliosides determine the amyloid pathology of Alzheimer's disease.
Oue Miho; Mitsumura Kazuhiro; Torashima Takashi; Koyama Chiho; Yamaguchi Haruyasu; Furuya Nobuhiko; Hirai Hirokazu
Characterization of mutant mice that express polyglutamine in cerebellar Purkinje cells.
Torashima Takashi; Koyama Chiho; Iizuka Akira; Mitsumura Kazuhiro; Takayama Kiyohiko; Yanagi Shigeru; Oue Miho; Yamaguchi Haruyasu; Hirai Hirokazu
Lentivector-mediated rescue from cerebellar ataxia in a mouse model of spinocerebellar ataxia.

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All Publications

2009: Oikawa Naoto; Yamaguchi Haruyasu; Ogino Koichi; Taki Takao; Yuyama Kohei; Yamamoto Naoki; Shin Ryong-Woon; Furukawa Koichi; Yanagisawa Katsuhiko
Gangliosides determine the amyloid pathology of Alzheimer's disease.
Neuroreport 2009;20(12):1043-6.
2009: Oue Miho; Mitsumura Kazuhiro; Torashima Takashi; Koyama Chiho; Yamaguchi Haruyasu; Furuya Nobuhiko; Hirai Hirokazu
Characterization of mutant mice that express polyglutamine in cerebellar Purkinje cells.
Brain research 2009;1255():9-17.
2008: Torashima Takashi; Koyama Chiho; Iizuka Akira; Mitsumura Kazuhiro; Takayama Kiyohiko; Yanagi Shigeru; Oue Miho; Yamaguchi Haruyasu; Hirai Hirokazu
Lentivector-mediated rescue from cerebellar ataxia in a mouse model of spinocerebellar ataxia.
EMBO reports 2008;9(4):393-9.
2008: Lemere Cynthia A; Oh Jiwon; Stanish Heather A; Peng Ying; Pepivani Imelda; Fagan Anne M; Yamaguchi Haruyasu; Westmoreland Susan V; Mansfield Keith G
Cerebral amyloid-beta protein accumulation with aging in cotton-top tamarins: a model of early Alzheimer's disease?
Rejuvenation research 2008;11(2):321-32.
2007: Zou Kun; Yamaguchi Haruyasu; Akatsu Hiroyasu; Sakamoto Takaaki; Ko Mihee; Mizoguchi Kazushige; Gong Jian-Sheng; Yu Wenxin; Yamamoto Takayuki; Kosaka Kenji; Yanagisawa Katsuhiko; Michikawa Makoto
Angiotensin-converting enzyme converts amyloid beta-protein 1-42 (Abeta(1-42)) to Abeta(1-40), and its inhibition enhances brain Abeta deposition.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(32):8628-35.
2007: Thal Dietmar Rudolf; Larionov Sergey; Abramowski Dorothee; Wiederhold Karl-Heinz; Van Dooren Tom; Yamaguchi Haruyasu; Haass Christian; Van Leuven Fred; Staufenbiel Matthias; Capetillo-Zarate Estibaliz
Occurrence and co-localization of amyloid beta-protein and apolipoprotein E in perivascular drainage channels of wild-type and APP-transgenic mice.
Neurobiology of aging 2007;28(8):1221-30.
2006: Capetillo-Zarate Estibaliz; Staufenbiel Matthias; Abramowski Dorothee; Haass Christian; Escher Angelika; Stadelmann Christine; Yamaguchi Haruyasu; Wiestler Otmar D; Thal Dietmar Rudolf
Selective vulnerability of different types of commissural neurons for amyloid beta-protein-induced neurodegeneration in APP23 mice correlates with dendritic tree morphology.
Brain : a journal of neurology 2006;129(Pt 11):2992-3005.
2006: Huang Shu-Ming; Mouri Akihiro; Kokubo Hideko; Nakajima Ryuichi; Suemoto Takahiro; Higuchi Makoto; Staufenbiel Matthias; Noda Yukihiro; Yamaguchi Haruyasu; Nabeshima Toshitaka; Saido Takaomi C; Iwata Nobuhisa
Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function.
The Journal of biological chemistry 2006;281(26):17941-51.
2006: Kawai Satoru; Ikeda Eiji; Sugiyama Munehiro; Matsumoto Jun; Higuchi Tetsuya; Zhang Hong; Khan Nasim; Tomiyoshi Katsumi; Inoue Tomio; Yamaguchi Haruyasu; Katakura Ken; Endo Keigo; Matsuda Hajime; Suzuki Mamoru
Enhancement of splenic glucose metabolism during acute malarial infection: correlation of findings of FDG-PET imaging with pathological changes in a primate model of severe human malaria.
The American journal of tropical medicine and hygiene 2006;74(3):353-60.
2006: van Leeuwen F W; van Tijn P; Sonnemans M A F; Hobo B; Mann D M A; Van Broeckhoven C; Kumar-Singh S; Cras P; Leuba G; Savioz A; Maat-Schieman M L C; Yamaguchi H; Kros J M; Kamphorst W; Hol E M; de Vos R A I; Fischer D F
Frameshift proteins in autosomal dominant forms of Alzheimer disease and other tauopathies.
Neurology 2006;66(2 Suppl 1):S86-92.
2005: Yamaguchi Haruyasu
Illustration of dynamic changes in Alzheimer pathology: from mild cognitive impairment to terminal stage.
Neuropathology : official journal of the Japanese Society of Neuropathology 2005;25(4):285-7.
2005: Miyasaka Tomohiro; Ding Zhen; Gengyo-Ando Keiko; Oue Miho; Yamaguchi Haruyasu; Mitani Shohei; Ihara Yasuo
Progressive neurodegeneration in C. elegans model of tauopathy.
Neurobiology of disease 2005;20(2):372-83.
2005: Thal Dietmar Rudolf; Capetillo-Zarate Estibaliz; Schultz Christian; Rüb Udo; Saido Takaomi C; Yamaguchi Haruyasu; Haass Christian; Griffin W Sue T; Del Tredici Kelly; Braak Heiko; Ghebremedhin Estifanos
Apolipoprotein E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent manner.
Acta neuropathologica 2005;110(5):459-71.
2005: Yamamoto Naoki; Yokoseki Tatsuki; Shibata Masao; Yamaguchi Haruyasu; Yanagisawa Katsuhiko
Suppression of Abeta deposition in brain by peripheral administration of Fab fragments of anti-seed antibody.
Biochemical and biophysical research communications 2005;335(1):45-7.
2005: Kokubo Hideko; Kayed Rakez; Glabe Charles G; Saido Takaomi C; Iwata Nobuhisa; Helms J Bernd; Yamaguchi Haruyasu
Oligomeric proteins ultrastructurally localize to cell processes, especially to axon terminals with higher density, but not to lipid rafts in Tg2576 mouse brain.
Brain research 2005;1045(1-2):224-8.
2005: Yamamoto Naoki; Hirabayashi Yoshio; Amari Masakuni; Yamaguchi Haruyasu; Romanov Galina; Van Nostrand William E; Yanagisawa Katsuhiko
Assembly of hereditary amyloid beta-protein variants in the presence of favorable gangliosides.
FEBS letters 2005;579(10):2185-90.
2005: Kokubo Hideko; Saido Takaomi C; Iwata Nobuhisa; Helms J Bernd; Shinohara Rumi; Yamaguchi Haruyasu
Part of membrane-bound Abeta exists in rafts within senile plaques in Tg2576 mouse brain.
Neurobiology of aging 2005;26(4):409-18.
2005: Kokubo Hideko; Kayed Rakez; Glabe Charles G; Yamaguchi Haruyasu
Soluble Abeta oligomers ultrastructurally localize to cell processes and might be related to synaptic dysfunction in Alzheimer's disease brain.
Brain research 2005;1031(2):222-8.
2004: Horikoshi Yuko; Mori Takashi; Maeda Masahiro; Kinoshita Noriaki; Sato Kumiko; Yamaguchi Haruyasu
Abeta N-terminal-end specific antibody reduced beta-amyloid in Alzheimer-model mice.
Biochemical and biophysical research communications 2004;325(2):384-7.
2004: Sugiyama Munehiro; Ikeda Eiji; Kawai Satoru; Higuchi Tetsuya; Zhang Hong; Khan Nasim; Tomiyoshi Katsumi; Inoue Tomio; Yamaguchi Haruyasu; Katakura Ken; Endo Keigo; Suzuki Mamoru
Cerebral metabolic reduction in severe malaria: fluorodeoxyglucose-positron emission tomography imaging in a primate model of severe human malaria with cerebral involvement.
The American journal of tropical medicine and hygiene 2004;71(5):542-5.
2004: Sasaki A; Yamaguchi H; Horikoshi Y; Tanaka G; Nakazato Y
Expression of glucose transporter 5 by microglia in human gliomas.
Neuropathology and applied neurobiology 2004;30(5):447-55.
2004: Horikoshi Yuko; Sakaguchi Gaku; Becker Amanda G; Gray Audrey J; Duff Karen; Aisen Paul S; Yamaguchi Haruyasu; Maeda Masahiro; Kinoshita Noriaki; Matsuoka Yasuji
Development of Abeta terminal end-specific antibodies and sensitive ELISA for Abeta variant.
Biochemical and biophysical research communications 2004;319(3):733-7.
2004: Hayashi Hideki; Kimura Nobuyuki; Yamaguchi Haruyasu; Hasegawa Kazuhiro; Yokoseki Tatsuki; Shibata Masao; Yamamoto Naoki; Michikawa Makoto; Yoshikawa Yasuhiro; Terao Keiji; Matsuzaki Katsumi; Lemere Cynthia A; Selkoe Dennis J; Naiki Hironobu; Yanagisawa Katsuhiko
A seed for Alzheimer amyloid in the brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(20):4894-902.
2004: Maat-Schieman Marion L C; Yamaguchi Haruyasu; Hegeman-Kleinn Ingrid M; Welling-Graafland Corrie; Natté Remco; Roos Raymund A C; van Duinen Sjoerd G
Glial reactions and the clearance of amyloid beta protein in the brains of patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type.
Acta neuropathologica 2004;107(5):389-98.
2004: Taguchi Nao; Hatabu Toshimitsu; Yamaguchi Haruyasu; Suzuki Mamoru; Sato Kumiko; Kano Shigeyuki
Plasmodium falciparum: selenium-induced cytotoxicity to P. falciparum.
Experimental parasitology 2004;106(1-2):50-5.
2003: Araki Yoichi; Tomita Susumu; Yamaguchi Haruyasu; Miyagi Naomi; Sumioka Akio; Kirino Yutaka; Suzuki Toshiharu
Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism.
The Journal of biological chemistry 2003;278(49):49448-58.
2003: Hashimoto Naoki; Takeuchi Tohru; Ishihara Ryoko; Ukai Katsuyuki; Kobayashi Hiroshi; Iwata Hiromu; Iwai Kiyoshi; Mizuno Yutaka; Yamaguchi Haruyasu; Shibayama Hiroto
Glial fibrillary tangles in diffuse neurofibrillary tangles with calcification.
Acta neuropathologica 2003;106(2):150-6.
2003: Rofina J; van Andel I; van Ederen A M; Papaioannou N; Yamaguchi H; Gruys Erik
Canine counterpart of senile dementia of the Alzheimer type: amyloid plaques near capillaries but lack of spatial relationship with activated microglia and macrophages.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2003;10(2):86-96.
2003: Kanamori Takashi; Nishimaki Kiyomi; Asoh Sadamitsu; Ishibashi Yoshitomo; Takata Iichiro; Kuwabara Tomoko; Taira Kazunari; Yamaguchi Haruyasu; Sugihara Shiro; Yamazaki Tsuneo; Ihara Yasuo; Nakano Kyoko; Matuda Sadayuki; Ohta Shigeo
Truncated product of the bifunctional DLST gene involved in biogenesis of the respiratory chain.
The EMBO journal 2003;22(12):2913-23.
2003: Kokubo Hideko; Helms J Bernd; Ohno-Iwashita Yoshiko; Shimada Yukiko; Horikoshi Yuko; Yamaguchi Haruyasu
Ultrastructural localization of flotillin-1 to cholesterol-rich membrane microdomains, rafts, in rat brain tissue.
Brain research 2003;965(1-2):83-90.
2003: Sasaki Atsushi; Horikoshi Yuko; Yokoo Hideaki; Nakazato Yoichi; Yamaguchi Haruyasu
Antiserum against human glucose transporter 5 is highly specific for microglia among cells of the mononuclear phagocyte system.
Neuroscience letters 2003;338(1):17-20.
2003: Horikoshi Y; Sasaki A; Taguchi N; Maeda M; Tsukagoshi H; Sato K; Yamaguchi H
Human GLUT5 immunolabeling is useful for evaluating microglial status in neuropathological study using paraffin sections.
Acta neuropathologica 2003;105(2):157-62.
2002: Takahashi Reisuke H; Milner Teresa A; Li Feng; Nam Ellen E; Edgar Mark A; Yamaguchi Haruyasu; Beal M Flint; Xu Huaxi; Greengard Paul; Gouras Gunnar K
Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology.
The American journal of pathology 2002;161(5):1869-79.
2002: Xia Xuefeng; Wang Pei; Sun Xiaoyan; Soriano Salvador; Shum Wan-Kyng; Yamaguchi Haruyasu; Trumbauer Myrna E; Takashima Akihiko; Koo Edward H; Zheng Hui
The aspartate-257 of presenilin 1 is indispensable for mouse development and production of beta-amyloid peptides through beta-catenin-independent mechanisms.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(13):8760-5.
2002: Sai Xiaorei; Kawamura Yuuki; Kokame Koichi; Yamaguchi Haruyasu; Shiraishi Hirohisa; Suzuki Ryo; Suzuki Toshiharu; Kawaichi Masashi; Miyata Toshiyuki; Kitamura Toshio; De Strooper Bart; Yanagisawa Katsuhiko; Komano Hiroto
Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein.
The Journal of biological chemistry 2002;277(15):12915-20.
2002: Thal Dietmar Rudolf; Ghebremedhin Estifanos; Rüb Udo; Yamaguchi Haruyasu; Del Tredici Kelly; Braak Heiko
Two types of sporadic cerebral amyloid angiopathy.
Journal of neuropathology and experimental neurology 2002;61(3):282-93.
2002: Sun X; Sato S; Murayama O; Murayama M; Park J-M; Yamaguchi H; Takashima A
Lithium inhibits amyloid secretion in COS7 cells transfected with amyloid precursor protein C100.
Neuroscience letters 2002;321(1-2):61-4.
2002: Sun Xiaoyan; Cole Gregory M; Chu Teresa; Xia Weiming; Galasko Douglas; Yamaguchi Haruyasu; Tanemura Kentaro; Frautschy Sally A; Takashima Akihiko
Intracellular Abeta is increased by okadaic acid exposure in transfected neuronal and non-neuronal cell lines.
Neurobiology of aging 2002;23(2):195-203.
2002: Tanemura Kentaro; Murayama Miyuki; Akagi Takumi; Hashikawa Tsutomu; Tominaga Takashi; Ichikawa Michinori; Yamaguchi Haruyasu; Takashima Akihiko
Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(1):133-41.
2001: Tanemura K; Akagi T; Murayama M; Kikuchi N; Murayama O; Hashikawa T; Yoshiike Y; Park J M; Matsuda K; Nakao S; Sun X; Sato S; Yamaguchi H; Takashima A
Formation of filamentous tau aggregations in transgenic mice expressing V337M human tau.
Neurobiology of disease 2001;8(6):1036-45.
2001: Yamaguchi H; Sugihara S; Ogawa A; Oshima N; Ihara Y
Alzheimer beta amyloid deposition enhanced by apoE epsilon4 gene precedes neurofibrillary pathology in the frontal association cortex of nondemented senior subjects.
Journal of neuropathology and experimental neurology 2001;60(7):731-9.
2001: Oshima N; Morishima-Kawashima M; Yamaguchi H; Yoshimura M; Sugihara S; Khan K; Games D; Schenk D; Ihara Y
Accumulation of amyloid beta-protein in the low-density membrane domain accurately reflects the extent of beta-amyloid deposition in the brain.
The American journal of pathology 2001;158(6):2209-18.
2000: Morishima-Kawashima M; Oshima N; Ogata H; Yamaguchi H; Yoshimura M; Sugihara S; Ihara Y
Effect of apolipoprotein E allele epsilon4 on the initial phase of amyloid beta-protein accumulation in the human brain.
The American journal of pathology 2000;157(6):2093-9.
2000: Thal D R; Schultz C; Dehghani F; Yamaguchi H; Braak H; Braak E
Amyloid beta-protein (Abeta)-containing astrocytes are located preferentially near N-terminal-truncated Abeta deposits in the human entorhinal cortex.
Acta neuropathologica 2000;100(6):608-17.
2000: Yamaguchi H; Maat-Schieman M L; van Duinen S G; Prins F A; Neeskens P; Natté R; Roos R A
Amyloid beta protein (Abeta) starts to deposit as plasma membrane-bound form in diffuse plaques of brains from hereditary cerebral hemorrhage with amyloidosis-Dutch type, Alzheimer disease and nondemented aged subjects.
Journal of neuropathology and experimental neurology 2000;59(8):723-32.
2000: Kokubo H; Lemere C A; Yamaguchi H
Localization of flotillins in human brain and their accumulation with the progression of Alzheimer's disease pathology.
Neuroscience letters 2000;290(2):93-6.
2000: Oue M; Yamaguchi H; Sato K; Suzuki M
Immunohistochemical localization of acid proteinase in Ascaris suum adult worm.
Experimental parasitology 2000;95(2):144-7.
2000: Maat-Schieman M L; Yamaguchi H; van Duinen S G; Natté R; Roos R A
Age-related plaque morphology and C-terminal heterogeneity of amyloid beta in Dutch-type hereditary cerebral hemorrhage with amyloidosis.
Acta neuropathologica 2000;99(4):409-19.
2000: Tsuzuki K; Fukatsu R; Yamaguchi H; Tateno M; Imai K; Fujii N; Yamauchi T
Transthyretin binds amyloid beta peptides, Abeta1-42 and Abeta1-40 to form complex in the autopsied human kidney - possible role of transthyretin for abeta sequestration.
Neuroscience letters 2000;281(2-3):171-4.
2000: Fakla I; Kovacs I; Yamaguchi H; Geula C; Kasa P
Expressions of amyloid precursor protein, synaptophysin and presenilin-1 in the different areas of the developing cerebellum of rat.
Neurochemistry international 2000;36(2):143-51.
2000: Kasa P; Papp H; Kovacs I; Forgon M; Penke B; Yamaguchi H
Human amyloid-beta1-42 applied in vivo inhibits the fast axonal transport of proteins in the sciatic nerve of rat.
Neuroscience letters 2000;278(1-2):117-9.
1999: Natté R; Yamaguchi H; Maat-Schieman M L; Prins F A; Neeskens P; Roos R A; van Duinen S G
Ultrastructural evidence of early non-fibrillar Abeta42 in the capillary basement membrane of patients with hereditary cerebral hemorrhage with amyloidosis, Dutch type.
Acta neuropathologica 1999;98(6):577-82.
1999: Ishiguro K; Ohno H; Arai H; Yamaguchi H; Urakami K; Park J M; Sato K; Kohno H; Imahori K
Phosphorylated tau in human cerebrospinal fluid is a diagnostic marker for Alzheimer's disease.
Neuroscience letters 1999;270(2):91-4.
1999: Enya M; Morishima-Kawashima M; Yoshimura M; Shinkai Y; Kusui K; Khan K; Games D; Schenk D; Sugihara S; Yamaguchi H; Ihara Y
Appearance of sodium dodecyl sulfate-stable amyloid beta-protein (Abeta) dimer in the cortex during aging.
The American journal of pathology 1999;154(1):271-9.
1998: Takashima A; Honda T; Yasutake K; Michel G; Murayama O; Murayama M; Ishiguro K; Yamaguchi H
Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons.
Neuroscience research 1998;31(4):317-23.
1998: Takashima A; Murayama M; Murayama O; Kohno T; Honda T; Yasutake K; Nihonmatsu N; Mercken M; Yamaguchi H; Sugihara S; Wolozin B
Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(16):9637-41.
1998: Hayashi Y; Fukatsu R; Tsuzuki K; Yoshida T; Sasaki N; Kimura K; Yamaguchi H; St George-Hyslop P H; Fujii N; Takahata N
Evidence for presenilin-1 involvement in amyloid angiopathy in the Alzheimer's disease-affected brain.
Brain research 1998;789(2):307-14.
1998: Yamaguchi H; Sugihara S; Ogawa A; Saido T C; Ihara Y
Diffuse plaques associated with astroglial amyloid beta protein, possibly showing a disappearing stage of senile plaques.
Acta neuropathologica 1998;95(3):217-22.
1998: Imahori K; Hoshi M; Ishiguro K; Sato K; Takahashi M; Shiurba R; Yamaguchi H; Takashima A; Uchida T
Possible role of tau protein kinases in pathogenesis of Alzheimer's disease.
Neurobiology of aging 1998;19(1 Suppl):S93-8.
1997: Sasaki A; Yamaguchi H; Ogawa A; Sugihara S; Nakazato Y
Microglial activation in early stages of amyloid beta protein deposition.
Acta neuropathologica 1997;94(4):316-22.
1997: Tsuzuki K; Fukatsu R; Hayashi Y; Yoshida T; Sasaki N; Takamaru Y; Yamaguchi H; Tateno M; Fujii N; Takahata N
Amyloid beta protein and transthyretin, sequestrating protein colocalize in normal human kidney.
Neuroscience letters 1997;222(3):163-6.
1996: Yamaguchi H
[Alzheimer's disease and apolipoprotein E]
No to shinkei = Brain and nerve 1996;48(11):981-90.
1996: Lemere C A; Lopera F; Kosik K S; Lendon C L; Ossa J; Saido T C; Yamaguchi H; Ruiz A; Martinez A; Madrigal L; Hincapie L; Arango J C; Anthony D C; Koo E H; Goate A M; Selkoe D J; Arango J C
The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology.
Nature medicine 1996;2(10):1146-50.
1996: Yamaguchi H; Ishiguro K; Uchida T; Takashima A; Lemere C A; Imahori K
Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3 beta and cyclin-dependent kinase 5, a component of TPK II.
Acta neuropathologica 1996;92(3):232-41.
1996: Lemere C A; Blusztajn J K; Yamaguchi H; Wisniewski T; Saido T C; Selkoe D J
Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.
Neurobiology of disease 1996;3(1):16-32.
1995: Tsuzuki K; Fukatsu R; Takamaru Y; Yoshida T; Hayashi Y; Yamaguchi H; Fujii N; Takahata N
Amyloid beta protein in rat soleus muscle in chloroquine-induced myopathy using end-specific antibodies for A beta 40 and A beta 42: immunohistochemical evidence for amyloid beta protein.
Neuroscience letters 1995;202(1-2):77-80.
1995: Takashima A; Yamaguchi H; Noguchi K; Michel G; Ishiguro K; Sato K; Hoshino T; Hoshi M; Imahori K
Amyloid beta peptide induces cytoplasmic accumulation of amyloid protein precursor via tau protein kinase I/glycogen synthase kinase-3 beta in rat hippocampal neurons.
Neuroscience letters 1995;198(2):83-6.
1995: Sugihara S; Ogawa A; Nakazato Y; Yamaguchi H
Cerebral beta amyloid deposition in patients with malignant neoplasms: its prevalence with aging and effects of radiation therapy on vascular amyloid.
Acta neuropathologica 1995;90(2):135-41.
1994: Yamaguchi H; Yamazaki T; Kawarabayashi T; Sun X; Sakai Y; Hirai S
Localization of Alzheimer amyloid beta protein precursor and its relation to senile plaque amyloid.
Gerontology 1994;40 Suppl 2():65-70.
1994: Yamaguchi H; Ishiguro K; Sugihara S; Nakazato Y; Kawarabayashi T; Sun X; Hirai S
Presence of apolipoprotein E on extracellular neurofibrillary tangles and on meningeal blood vessels precedes the Alzheimer beta-amyloid deposition.
Acta neuropathologica 1994;88(5):413-9.
1993: Kawarabayashi T; Shoji M; Yamaguchi H; Tanaka M; Harigaya Y; Ishiguro K; Hirai S
Amyloid beta protein precursor accumulates in swollen neurites throughout rat brain with aging.
Neuroscience letters 1993;153(1):73-6.
1993: Ikeda M; Shoji M; Yamaguchi H; Matsubara E; Amari M; Ishiguro K; Kawarabayashi T; Harigaya Y; Hirai S
Diagnostic significance of skin immunolabelling with antibody against native cerebral amyloid in Alzheimer's disease.
Neuroscience letters 1993;150(2):159-61.
1993: Ishiguro K; Shoji M; Yamaguchi H; Matsubara E; Ikeda M; Kawarabayashi T; Harigaya Y; Okamoto K; Hirai S
Differential expression of alpha 1-antichymotrypsin in the aged human brain.
Virchows Archiv. B, Cell pathology including molecular pathology 1993;64(4):221-7.
1993: Yamazaki T; Yamaguchi H; Kawarabayashi T; Hirai S
Ultrastructural localization of amyloid beta/A4 protein precursor in the normal rat brain.
Virchows Archiv. B, Cell pathology including molecular pathology 1993;63(3):173-80.
1992: Imagawa M; Naruse S; Tsuji S; Fujioka A; Yamaguchi H
Coenzyme Q10, iron, and vitamin B6 in genetically-confirmed Alzheimer's disease.
Lancet 1992;340(8820):671.
1992: Yamaguchi H; Yamazaki T; Lemere C A; Frosch M P; Selkoe D J
Beta amyloid is focally deposited within the outer basement membrane in the amyloid angiopathy of Alzheimer's disease. An immunoelectron microscopic study.
The American journal of pathology 1992;141(1):249-59.
1992: Yamazaki T; Yamaguchi H; Nakazato Y; Ishiguro K; Kawarabayashi T; Hirai S
Ultrastructural characterization of cerebellar diffuse plaques in Alzheimer's disease.
Journal of neuropathology and experimental neurology 1992;51(3):281-6.
1992: Yamaguchi H; Yamazaki T; Ishiguro K; Shoji M; Nakazato Y; Hirai S
Ultrastructural localization of Alzheimer amyloid beta/A4 protein precursor in the cytoplasm of neurons and senile plaque-associated astrocytes.
Acta neuropathologica 1992;85(1):15-22.
1991: Kawarabayashi T; Shoji M; Harigaya Y; Yamaguchi H; Hirai S
Expression of APP in the early stage of brain damage.
Brain research 1991;563(1-2):334-8.
1991: Kawarabayashi T; Shoji M; Harigaya Y; Yamaguchi H; Hirai S
Amyloid beta/A4 protein precursor is widely distributed in both the central and peripheral nervous systems of the mouse.
Brain research 1991;552(1):1-7.
1991: Yamaguchi H; Nakazato Y; Shoji M; Okamoto K; Ihara Y; Morimatsu M; Hirai S
Secondary deposition of beta amyloid within extracellular neurofibrillary tangles in Alzheimer-type dementia.
The American journal of pathology 1991;138(3):699-705.
1991: Yamaguchi H; Nakazato Y; Yamazaki T; Shoji M; Kawarabayashi T; Hirai S
Subpial beta/A4 amyloid deposition occurs between astroglial processes in Alzheimer-type dementia.
Neuroscience letters 1991;123(2):217-20.
1991: Shoji M; Hirai S; Yamaguchi H; Harigaya Y; Ishiguro K; Matsubara E
Alpha 1-antichymotrypsin is present in diffuse senile plaques. A comparative study of beta-protein and alpha 1-antichymotrypsin immunostaining in the Alzheimer brain.
The American journal of pathology 1991;138(1):247-57.
1991: Yamaguchi H; Nakazato Y; Shoji M; Takatama M; Hirai S
Ultrastructure of diffuse plaques in senile dementia of the Alzheimer type: comparison with primitive plaques.
Acta neuropathologica 1991;82(1):13-20.
1991: Yamaguchi H; Nakazato Y; Kawarabayashi T; Ishiguro K; Ihara Y; Morimatsu M; Hirai S
Extracellular neurofibrillary tangles associated with degenerating neurites and neuropil threads in Alzheimer-type dementia.
Acta neuropathologica 1991;81(6):603-9.
1991: Sasaki A; Nakanishi Y; Nakazato Y; Yamaguchi H
Application of lectin and B-lymphocyte-specific monoclonal antibodies for the demonstration of human microglia in formalin-fixed, paraffin-embedded brain tissue.
Virchows Archiv. A, Pathological anatomy and histopathology 1991;419(4):291-9.
1991: Yamazaki T; Yamaguchi H; Okamoto K; Hirai S
Ultrastructural localization of argyrophilic substances in diffuse plaques of Alzheimer-type dementia demonstrated by methenamine silver staining.
Acta neuropathologica 1991;81(5):540-5.
1990: Yamaguchi H; Ishiguro K; Shoji M; Yamazaki T; Nakazato Y; Ihara Y; Hirai S
Amyloid beta/A4 protein precursor is bound to neurofibrillary tangles in Alzheimer-type dementia.
Brain research 1990;537(1-2):318-22.
1990: Shoji M; Kawarabayashi T; Harigaya Y; Yamaguchi H; Hirai S; Kamimura T; Sugiyama T
Alzheimer amyloid beta-protein precursor in sperm development.
The American journal of pathology 1990;137(5):1027-32.
1990: Matsubara E; Hirai S; Amari M; Shoji M; Yamaguchi H; Okamoto K; Ishiguro K; Harigaya Y; Wakabayashi K
Alpha 1-antichymotrypsin as a possible biochemical marker for Alzheimer-type dementia.
Annals of neurology 1990;28(4):561-7.
1990: Shoji M; Hirai S; Harigaya Y; Kawarabayashi T; Yamaguchi H
The amyloid beta-protein precursor is localized in smooth muscle cells of leptomeningeal vessels.
Brain research 1990;530(1):113-6.
1990: Sotomatsu A; Tanaka M; Yamaguchi H; Okamoto K; Hirai S
[Systemic lupus erythematosus presenting chronic relapsing polyneuropathy as the first manifestation without auto-antibodies]
Rinsho shinkeigaku = Clinical neurology 1990;30(9):985-8.
1990: Nakazato Y; Yamazaki H; Hirato J; Ishida Y; Yamaguchi H
Oligodendroglial microtubular tangles in olivopontocerebellar atrophy.
Journal of neuropathology and experimental neurology 1990;49(5):521-30.
1990: Shoji M; Hirai S; Yamaguchi H; Harigaya Y; Kawarabayashi T
Amyloid beta-protein precursor accumulates in dystrophic neurites of senile plaques in Alzheimer-type dementia.
Brain research 1990;512(1):164-8.
1990: Yamaguchi H; Nakazato Y; Hirai S; Shoji M
Immunoelectron microscopic localization of amyloid beta protein in the diffuse plaques of Alzheimer-type dementia.
Brain research 1990;508(2):320-4.
1990: Yamaguchi H; Nakazato Y; Shoji M; Ihara Y; Hirai S
Ultrastructure of the neuropil threads in the Alzheimer brain: their dendritic origin and accumulation in the senile plaques.
Acta neuropathologica 1990;80(4):368-74.
1990: Yamaguchi H; Haga C; Hirai S; Nakazato Y; Kosaka K
Distinctive, rapid, and easy labeling of diffuse plaques in the Alzheimer brains by a new methenamine silver stain.
Acta neuropathologica 1990;79(5):569-72.
1989: Yamaguchi H; Nakazato Y; Hirai S; Shoji M; Harigaya Y
Electron micrograph of diffuse plaques. Initial stage of senile plaque formation in the Alzheimer brain.
The American journal of pathology 1989;135(4):593-7.
1989: Shoji M; Harigaya Y; Yamaguchi H; Okamoto K; Hirai S
[An immunocytochemical study of alpha 1-antichymotrypsin in the senescent cerebral amyloid]
Rinsho shinkeigaku = Clinical neurology 1989;29(1):30-9.
1989: Okamoto K; Yamaguchi H; Hirai S; Shoji M; Inoue K; Takatama M
Immunogold electron microscopic study of cerebrovascular and senile plaque amyloid using anti-beta protein antibody.
Progress in clinical and biological research 1989;317():953-63.
1989: Matsubara E; Amari M; Shoji M; Harigaya Y; Yamaguchi H; Okamoto K; Hirai S
Serum concentration of alpha 1-antichymotrypsin is elevated in patients with senile dementia of the Alzheimer type.
Progress in clinical and biological research 1989;317():707-14.
1989: Shoji M; Harigaya Y; Yamaguchi H; Okamoto K; Hirai S; Takatama M
Immunocytochemical study of alpha 1-antichymotrypsin in the senescent cerebral amyloid.
Progress in clinical and biological research 1989;317():1049-59.
1989: Harigaya Y; Shoji M; Yamaguchi H; Hirai S; Takatama M
A study of beta protein precursor using antiserum against a synthetic peptide (1-28).
Progress in clinical and biological research 1989;317():945-52.
1989: Yamaguchi H; Hirai S; Shoji M; Harigaya Y; Okamoto Y; Nakazato Y
Alzheimer type dementia: diffuse type of senile plaques demonstrated by beta protein immunostaining.
Progress in clinical and biological research 1989;317():467-74.
1989: Yamaguchi H; Hirai S; Morimatsu M; Shoji M; Nakazato Y
Diffuse type of senile plaques in the cerebellum of Alzheimer-type dementia demonstrated by beta protein immunostain.
Acta neuropathologica 1989;77(3):314-9.
1988: Yamaguchi H; Hirai S; Momimatsu M; Ihara Y
[A comparative study on the ability to stain senile plaques with beta protein immunostain and three kinds of silver impregnation methods]
Rinsho shinkeigaku = Clinical neurology 1988;28(6):688-94.
1988: Shoji M; Harigaya Y; Okamoto K; Yamaguchi H; Hirai S
[The study of neuroactive substance within senile plaques--with special reference to somatostatin and substance P]
Rinsho shinkeigaku = Clinical neurology 1988;28(1):67-73.
1988: Yamaguchi H; Hirai S; Morimatsu M; Shoji M; Ihara Y
A variety of cerebral amyloid deposits in the brains of the Alzheimer-type dementia demonstrated by beta protein immunostaining.
Acta neuropathologica 1988;76(6):541-9.
1988: Yamaguchi H; Hirai S; Morimatsu M; Shoji M; Harigaya Y
Diffuse type of senile plaques in the brains of Alzheimer-type dementia.
Acta neuropathologica 1988;77(2):113-9.
1987: Yamaguchi H; Okamoto K; Shooji M; Morimatsu M; Hirai S
Muscle histology of hypocalcaemic myopathy in hypoparathyroidism.
Journal of neurology, neurosurgery, and psychiatry 1987;50(6):817-8.
1987: Yamaguchi H; Morimatsu M; Okamoto K; Hirai S
[Senile dementia of Alzheimer type--relation between types of senile plaques and dementia]
Rinsho shinkeigaku = Clinical neurology 1987;27(5):617-21.
1987: Yamaguchi H; Morimatsu M; Hirai S; Takahashi K
Alzheimer's neurofibrillary tangles are penetrated by astroglial processes and appear eosinophilic in their final stages.
Acta neuropathologica 1987;72(3):214-7.
1984: Okamoto K; Yamazaki T; Yamaguchi H; Morimatsu M; Hirai S
[An autopsy case of diffuse Lewy body disease]
Rinsho shinkeigaku = Clinical neurology 1984;24(10):975-83.
1983: Yamaguchi H; Okamoto K; Shooji M; Morimatsu M; Hirai S
[A case of adult type sialidosis with partial beta-galactosidase deficiency without myoclonus]
Rinsho shinkeigaku = Clinical neurology 1983;23(1):1-8.
1982: Okamoto K; Hirano A; Yamaguchi H; Hirai S
[The fine structure of eosinophilic stages of Alzheimer's neurofibrillary tangles]
Rinsho shinkeigaku = Clinical neurology 1982;22(9):840-6.

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