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Yuki Yamaguchi

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Chemicals & Drugs

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Kentaro Hotta; Yosuke Iizumi; Takeshi Imai; Takumi Ito; Yasuaki Kabe; Ryusuke Nabeshima; Akihiro Nashimoto; Akira Okada; Satoshi Sakamoto; Kumiko Sakata-Sogawa; Daisuke Shima; Masafumi Suzuki; Makio Tokunaga; Hajime Watanabe; Yuki Yamaguchi; Eiji Yasumura; Shinichi Aizawa; Hideki Ando; Motoki Azuma; Masaki Hiramoto; Hiroshi Handa
Vesnarinone suppresses TNFα mRNA expression by inhibiting valosin-containing protein.
Satoki Karasawa; Takeshi Kasama; Keisuke Miyazawa; Satoshi Sakamoto; Yuki Yamaguchi; Motoki Azuma; Takeshi Imai; Yasuaki Kabe; Hiroshi Handa
Vitamin K2 covalently binds to Bak and induces Bak-mediated apoptosis.
Yuki Yamaguchi; Hirotaka Shibata; Hiroshi Handa
Transcription elongation factors DSIF and NELF: promoter-proximal pausing and beyond.

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All Publications

2013: Kentaro Hotta; Yosuke Iizumi; Takeshi Imai; Takumi Ito; Yasuaki Kabe; Ryusuke Nabeshima; Akihiro Nashimoto; Akira Okada; Satoshi Sakamoto; Kumiko Sakata-Sogawa; Daisuke Shima; Masafumi Suzuki; Makio Tokunaga; Hajime Watanabe; Yuki Yamaguchi; Eiji Yasumura; Shinichi Aizawa; Hideki Ando; Motoki Azuma; Masaki Hiramoto; Hiroshi Handa
Vesnarinone suppresses TNFα mRNA expression by inhibiting valosin-containing protein.
Molecular pharmacology 2013;83(5):930-8.
2013: Satoki Karasawa; Takeshi Kasama; Keisuke Miyazawa; Satoshi Sakamoto; Yuki Yamaguchi; Motoki Azuma; Takeshi Imai; Yasuaki Kabe; Hiroshi Handa
Vitamin K2 covalently binds to Bak and induces Bak-mediated apoptosis.
Molecular pharmacology 2013;83(3):613-20.
2013: Yuki Yamaguchi; Hirotaka Shibata; Hiroshi Handa
Transcription elongation factors DSIF and NELF: promoter-proximal pausing and beyond.
Biochimica et biophysica acta 2013;1829(1):98-104.
2012: Yuki Ito; Satoki Karasawa; Yoshihisa Matsumoto; Tsuneyo Mimori; Akihiro Nashimoto; Satoshi Sakamoto; Yuki Yamaguchi; Teruya Enomoto; Yasuyoshi Hase; Takumi Ito; Hiroshi Handa
Identification of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) as a novel target of bisphenol A.
PloS one 2012;7(12):e50481.
2011: Teruya Enomoto; Masa-Aki Kawano; Iwao Kukimoto; Yuki Yamaguchi; Arnold J Berk; Hiroshi Handa
In vitro reconstitution of SV40 particles that are composed of VP1/2/3 capsid proteins and nucleosomal DNA and direct efficient gene transfer.
Virology 2011;420(1):1-9.
2011: Ayumi Kawano; Shuhei Noguchi; Hiroshi Handa; Yohei Hayashi; Masami Horikoshi; Yuki Yamaguchi
Global analysis for functional residues of histone variant Htz1 using the comprehensive point mutant library.
Genes to cells : devoted to molecular & cellular mechanisms 2011;16(5):590-607.
2011: Takuya Taneda; Wenyan Zhu; Qingfu Cao; Hajime Watanabe; Yuki Yamaguchi; Hiroshi Handa; Tadashi Wada
Erythropoiesis is regulated by the transcription elongation factor Foggy/Spt5 through gata1 gene regulation.
Genes to cells : devoted to molecular & cellular mechanisms 2011;16(2):231-42.
2010: Kunitoshi Chiba; Junichi Yamamoto; Yuki Yamaguchi; Hiroshi Handa
Promoter-proximal pausing and its release: molecular mechanisms and physiological functions.
Experimental cell research 2010;316(17):2723-30.
2010: Sol Kim; Junichi Yamamoto; Yexi Chen; Masatoshi Aida; Tadashi Wada; Hiroshi Handa; Yuki Yamaguchi
Evidence that cleavage factor Im is a heterotetrameric protein complex controlling alternative polyadenylation.
Genes to cells : devoted to molecular & cellular mechanisms 2010;15(9):1003-13.
2010: Kanako Kume; Yosuke Iizumi; Masashi Shimada; Yuki Ito; Tsutomu Kishi; Yuki Yamaguchi; Hiroshi Handa
Role of N-end rule ubiquitin ligases UBR1 and UBR2 in regulating the leucine-mTOR signaling pathway.
Genes to cells : devoted to molecular & cellular mechanisms 2010;15(4):339-49.
2010: Takumi Ito; Hideki Ando; Takayuki Suzuki; Toshihiko Ogura; Kentaro Hotta; Yoshimasa Imamura; Yuki Yamaguchi; Hiroshi Handa
Identification of a primary target of thalidomide teratogenicity.
Science (New York, N.Y.) 2010;327(5971):1345-50.
2010: Yuka Masaike; Takeshi Takagi; Masataka Hirota; Joe Yamada; Satoru Ishihara; Tetsu M C Yung; Takamasa Inoue; Chika Sawa; Hiroshi Sagara; Satoshi Sakamoto; Yasuaki Kabe; Yasuyuki Takahashi; Yuki Yamaguchi; Hiroshi Handa
Identification of dynamin-2-mediated endocytosis as a new target of osteoporosis drugs, bisphosphonates.
Molecular pharmacology 2010;77(2):262-9.
2009: Yexi Chen; Yuki Yamaguchi; Yuta Tsugeno; Junichi Yamamoto; Tomoko Yamada; Mitsuhiro Nakamura; Hisatake Koji; Hiroshi Handa
DSIF, the Paf1 complex, and Tat-SF1 have nonredundant, cooperative roles in RNA polymerase II elongation.
Genes & development 2009;23(23):2765-77.
2009: Tetsu M C Yung; Takashi Narita; Toshiharu Komori; Yuki Yamaguchi; Hiroshi Handa
Cellular dynamics of the negative transcription elongation factor NELF.
Experimental cell research 2009;315(10):1693-705.
2009: Chikanori Kuramori; Yasuyoshi Hase; Koichi Hoshikawa; Keiko Watanabe; Takeyuki Nishi; Takako Hishiki; Tomoyoshi Soga; Akihiro Nashimoto; Yasuaki Kabe; Yuki Yamaguchi; Hajime Watanabe; Kohsuke Kataoka; Makoto Suematsu; Hiroshi Handa
Mono-(2-ethylhexyl) phthalate targets glycogen debranching enzyme and affects glycogen metabolism in rat testis.
Toxicological sciences : an official journal of the Society of Toxicology 2009;109(1):143-51.
2009: Toshiharu Komori; Naoto Inukai; Tomoko Yamada; Yuki Yamaguchi; Hiroshi Handa
Role of human transcription elongation factor DSIF in the suppression of senescence and apoptosis.
Genes to cells : devoted to molecular & cellular mechanisms 2009;14(3):343-54.
2009: Chikanori Kuramori; Motoki Azuma; Kanako Kume; Yuki Kaneko; Atsushi Inoue; Yuki Yamaguchi; Yasuaki Kabe; Takamitsu Hosoya; Masahiro Kizaki; Makoto Suematsu; Hiroshi Handa
Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nucleus.
Biochemical and biophysical research communications 2009;379(2):519-25.
2009: Satoshi Sakamoto; Yasuaki Kabe; Mamoru Hatakeyama; Yuki Yamaguchi; Hiroshi Handa
Development and application of high-performance affinity beads: toward chemical biology and drug discovery.
Chemical record (New York, N.Y.) 2009;9(1):66-85.
2008: Kozue Ando; Satoshi Hirao; Yasuaki Kabe; Yuji Ogura; Iwao Sato; Yuki Yamaguchi; Tadashi Wada; Hiroshi Handa
A new APE1/Ref-1-dependent pathway leading to reduction of NF-kappaB and AP-1, and activation of their DNA-binding activity.
Nucleic acids research 2008;36(13):4327-36.
2008: Ryou-u Takahashi; Shin-nosuke Kanesashi; Takamasa Inoue; Teruya Enomoto; Masa-Aki Kawano; Hiroko Tsukamoto; Fumitaka Takeshita; Takeshi Imai; Takahiro Ochiya; Kohsuke Kataoka; Yuki Yamaguchi; Hiroshi Handa
Presentation of functional foreign peptides on the surface of SV40 virus-like particles.
Journal of biotechnology 2008;135(4):385-92.
2008: Masafumi Suzuki; Shoichiro Furukawa; Chikanori Kuramori; Chika Sawa; Yasuaki Kabe; Mitsuhiro Nakamura; Jun-Ichi Sawada; Yuki Yamaguchi; Satoshi Sakamoto; Satoshi Inouye; Hiroshi Handa
Development of a chemical screening system using aqueorin-fused protein.
Biochemical and biophysical research communications 2008;368(3):600-5.
2008: Yasuyoshi Hase; Michiko Tatsuno; Takeyuki Nishi; Kosuke Kataoka; Yasuaki Kabe; Yuki Yamaguchi; Nobuaki Ozawa; Michiya Natori; Hiroshi Handa; Hajime Watanabe
Atrazine binds to F1F0-ATP synthase and inhibits mitochondrial function in sperm.
Biochemical and biophysical research communications 2008;366(1):66-72.
2008: Motoki Azuma; Yasuaki Kabe; Chikanori Kuramori; Masao Kondo; Yuki Yamaguchi; Hiroshi Handa
Adenine nucleotide translocator transports haem precursors into mitochondria.
PloS one 2008;3(8):e3070.
2007: Hiroko Tsukamoto; Masa-Aki Kawano; Takamasa Inoue; Teruya Enomoto; Ryou-u Takahashi; Naoki Yokoyama; Noriaki Yamamoto; Takeshi Imai; Kohsuke Kataoka; Yuki Yamaguchi; Hiroshi Handa
Evidence that SV40 VP1-DNA interactions contribute to the assembly of 40-nm spherical viral particles.
Genes to cells : devoted to molecular & cellular mechanisms 2007;12(11):1267-79.
2007: Yuki Yamaguchi; Takashi Mura; Sittinan Chanarat; Sachiko Okamoto; Hiroshi Handa
Hepatitis delta antigen binds to the clamp of RNA polymerase II and affects transcriptional fidelity.
Genes to cells : devoted to molecular & cellular mechanisms 2007;12(7):863-75.
2007: Takashi Narita; Tetsu M C Yung; Junichi Yamamoto; Yasunori Tsuboi; Hideyuki Tanabe; Kiyoji Tanaka; Yuki Yamaguchi; Hiroshi Handa
NELF interacts with CBC and participates in 3' end processing of replication-dependent histone mRNAs.
Molecular cell 2007;26(3):349-65.
2007: Kosuke Nishio; Nobuyuki Gokon; Makoto Hasegawa; Yuji Ogura; Morihito Ikeda; Hiroki Narimatsu; Masaru Tada; Yuki Yamaguchi; Satoshi Sakamoto; Masanori Abe; Hiroshi Handa
Identification of a chemical substructure that is immobilized to ferrite nanoparticles (FP).
Colloids and surfaces. B, Biointerfaces 2007;54(2):249-53.
2007: Noriaki Yamamoto; Masato Suzuki; Masa-Aki Kawano; Takamasa Inoue; Ryou-u Takahashi; Hiroko Tsukamoto; Teruya Enomoto; Yuki Yamaguchi; Tadashi Wada; Hiroshi Handa
Adeno-associated virus site-specific integration is regulated by TRP-185.
Journal of virology 2007;81(4):1990-2001.
2007: Masato Yugami; Yasuaki Kabe; Yuki Yamaguchi; Tadashi Wada; Hiroshi Handa
hnRNP-U enhances the expression of specific genes by stabilizing mRNA.
FEBS letters 2007;581(1):1-7.
2007: Wenyan Zhu; Tadashi Wada; Sachiko Okabe; Takuya Taneda; Yuki Yamaguchi; Hiroshi Handa
DSIF contributes to transcriptional activation by DNA-binding activators by preventing pausing during transcription elongation.
Nucleic acids research 2007;35(12):4064-75.
2006: Masatoshi Aida; Yexi Chen; Koichi Nakajima; Yuki Yamaguchi; Tadashi Wada; Hiroshi Handa
Transcriptional pausing caused by NELF plays a dual role in regulating immediate-early expression of the junB gene.
Molecular and cellular biology 2006;26(16):6094-104.
2006: Yuji Ogura; Motoki Azuma; Yasunori Tsuboi; Yasuaki Kabe; Yuki Yamaguchi; Tadashi Wada; Hajime Watanabe; Hiroshi Handa
TFII-I down-regulates a subset of estrogen-responsive genes through its interaction with an initiator element and estrogen receptor alpha.
Genes to cells : devoted to molecular & cellular mechanisms 2006;11(4):373-81.
2006: Tomoko Yamada; Yuki Yamaguchi; Naoto Inukai; Sachiko Okamoto; Takashi Mura; Hiroshi Handa
P-TEFb-mediated phosphorylation of hSpt5 C-terminal repeats is critical for processive transcription elongation.
Molecular cell 2006;21(2):227-37.
2005: Sophie Deléhouzée; Tatsufumi Yoshikawa; Chika Sawa; Jun-ichi Sawada; Takumi Ito; Masashi Omori; Tadashi Wada; Yuki Yamaguchi; Yasuaki Kabe; Hiroshi Handa
GABP, HCF-1 and YY1 are involved in Rb gene expression during myogenesis.
Genes to cells : devoted to molecular & cellular mechanisms 2005;10(7):717-31.
2005: Yoshihiro Ohtsu; Reiko Ohba; Yoshimasa Imamura; Motoo Kobayashi; Hidetaka Hatori; Tatsuya Zenkoh; Mamoru Hatakeyama; Takashi Manabe; Motohiro Hino; Yuki Yamaguchi; Kohsuke Kataoka; Haruma Kawaguchi; Hajime Watanabe; Hiroshi Handa
Selective ligand purification using high-performance affinity beads.
Analytical biochemistry 2005;338(2):245-52.
2005: Yasuaki Kabe; Joe Yamada; Hitoshi Uga; Yuki Yamaguchi; Tadashi Wada; Hiroshi Handa
NF-Y is essential for the recruitment of RNA polymerase II and inducible transcription of several CCAAT box-containing genes.
Molecular and cellular biology 2005;25(1):512-22.
2004: Masaki Endoh; Wenyan Zhu; Jun Hasegawa; Hajime Watanabe; Dong-Ki Kim; Masatoshi Aida; Naoto Inukai; Takashi Narita; Tomoko Yamada; Akiko Furuya; Hiroe Sato; Yuki Yamaguchi; Subhrangsu S Mandal; Danny Reinberg; Tadashi Wada; Hiroshi Handa
Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro.
Molecular and cellular biology 2004;24(8):3324-36.
2004: Naoto Inukai; Yuki Yamaguchi; Isao Kuraoka; Tomoko Yamada; Sachiko Kamijo; Junko Kato; Kiyoji Tanaka; Hiroshi Handa
A novel hydrogen peroxide-induced phosphorylation and ubiquitination pathway leading to RNA polymerase II proteolysis.
The Journal of biological chemistry 2004;279(9):8190-5.
2003: Dong-Ki Kim; Naoto Inukai; Tomoko Yamada; Akiko Furuya; Hiroe Sato; Yuki Yamaguchi; Tadashi Wada; Hiroshi Handa
Structure-function analysis of human Spt4: evidence that hSpt4 and hSpt5 exert their roles in transcriptional elongation as parts of the DSIF complex.
Genes to cells : devoted to molecular & cellular mechanisms 2003;8(4):371-8.
2003: Daisuke Shima; Masato Yugami; Michiko Tatsuno; Tadashi Wada; Yuki Yamaguchi; Hiroshi Handa
Mechanism of H-8 inhibition of cyclin-dependent kinase 9: study using inhibitor-immobilized matrices.
Genes to cells : devoted to molecular & cellular mechanisms 2003;8(3):215-23.
2003: Takashi Narita; Yuki Yamaguchi; Keiichi Yano; Seiji Sugimoto; Sittinan Chanarat; Tadashi Wada; Dong-ki Kim; Jun Hasegawa; Masashi Omori; Naoto Inukai; Masaki Endoh; Tomoko Yamada; Hiroshi Handa
Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex.
Molecular and cellular biology 2003;23(6):1863-73.
2003: Jun Hasegawa; Masaki Endou; Takashi Narita; Tomoko Yamada; Yuki Yamaguchi; Tadashi Wada; Hiroshi Handa
A rapid purification method for human RNA polymerase II by two-step affinity chromatography.
Journal of biochemistry 2003;133(1):133-8.
2002: Takeyuki Nishi; Noriaki Shimizu; Masaki Hiramoto; Iwao Sato; Yuki Yamaguchi; Makoto Hasegawa; Shin Aizawa; Hirotoshi Tanaka; Kohsuke Kataoka; Hajime Watanabe; Hiroshi Handa
Spatial redox regulation of a critical cysteine residue of NF-kappa B in vivo.
The Journal of biological chemistry 2002;277(46):44548-56.
2002: Yuki Yamaguchi; Sophie Deléhouzée; Hiroshi Handa
HIV and hepatitis delta virus: evolution takes different paths to relieve blocks in transcriptional elongation.
Microbes and infection / Institut Pasteur 2002;4(11):1169-75.
2002: Yuki Yamaguchi; Naoto Inukai; Takashi Narita; Tadashi Wada; Hiroshi Handa
Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA.
Molecular and cellular biology 2002;22(9):2918-27.
2001: Yuki Yamaguchi; Julija Filipovska; Keiichi Yano; Akiko Furuya; Naoto Inukai; Takashi Narita; Tadashi Wada; Seiji Sugimoto; Maria M Konarska; Hiroshi Handa
Stimulation of RNA polymerase II elongation by hepatitis delta antigen.
Science (New York, N.Y.) 2001;293(5527):124-7.
2001: Yuki Yamaguchi; Takashi Narita; Naoto Inukai; Tadashi Wada; Hiroshi Handa
SPT genes: key players in the regulation of transcription, chromatin structure and other cellular processes.
Journal of biochemistry 2001;129(2):185-91.
2000: Tadashi Wada; G Orphanides; Jun Hasegawa; D K Kim; Daisuke Shima; Yuki Yamaguchi; A Fukuda; Hisatake Koji; S Oh; Danny Reinberg; Hiroshi Handa
FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH.
Molecular cell 2000;5(6):1067-72.
2000: Yuki Yamaguchi; Tadashi Wada; Hiroshi Handa
[Regulatory mechanism of transcription elongation: DRB-sensitive elongation control machinery].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2000;45(9 Suppl):1476-83.
2000: Yuki Yamaguchi; Tadashi Wada; Hiroshi Handa
[Mechanism of basal transcription].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2000;45(9 Suppl):1473-5.
1999: Yuki Yamaguchi; T Takagi; Tadashi Wada; Keiichi Yano; Akiko Furuya; Seiji Sugimoto; Jun Hasegawa; Hiroshi Handa
NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation.
Cell 1999;97(1):41-51.
1999: Yuki Yamaguchi; Tadashi Wada; D Watanabe; T Takagi; J Hasegawa; Hiroshi Handa
Structure and function of the human transcription elongation factor DSIF.
The Journal of biological chemistry 1999;274(12):8085-92.
1998: Tadashi Wada; T Takagi; Yuki Yamaguchi; D Watanabe; Hiroshi Handa
Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro.
The EMBO journal 1998;17(24):7395-403.
1998: Yuki Yamaguchi; Tadashi Wada; F Suzuki; T Takagi; J Hasegawa; Hiroshi Handa
Casein kinase II interacts with the bZIP domains of several transcription factors.
Nucleic acids research 1998;26(16):3854-61.
1998: Tadashi Wada; T Takagi; Yuki Yamaguchi; A Ferdous; T Imai; S Hirose; Seiji Sugimoto; Keiichi Yano; Grant A Hartzog; fred winston; S Buratowski; Hiroshi Handa
DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs.
Genes & development 1998;12(3):343-56.
1998: Yuki Yamaguchi; Tadashi Wada; Hiroshi Handa
Interplay between positive and negative elongation factors: drawing a new view of DRB.
Genes to cells : devoted to molecular & cellular mechanisms 1998;3(1):9-15.
1997: Yuki Yamaguchi; Jun-ichi Sawada; M Yamada; Hiroshi Handa; N Azuma
Autoregulation of Pax6 transcriptional activation by two distinct DNA-binding subdomains of the paired domain.
Genes to cells : devoted to molecular & cellular mechanisms 1997;2(4):255-61.
1996: Tadashi Wada; T Takagi; Yuki Yamaguchi; H Kawase; M Hiramoto; A Ferdous; M Takayama; K A Lee; H C Hurst; Hiroshi Handa
Copurification of casein kinase II with transcription factor ATF/E4TF3.
Nucleic acids research 1996;24(5):876-84.