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Hirohei Yamamura

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Takao Kashiwagi; Minoru Kishi; Satoshi Kusaka; Takao Mitsuhashi; Takuma Suzuki; Tamaki Hirata; Tadahiro Inagaki; Masahide Iwai; Naoki Yoshioka; Hirohei Yamamura
[Case report: family cases of datura poisoning].
Chisato Tanaka; Kaoru Tohyama; Takayuki Tsujioka; Hirohei Yamamura; Kunio Yokoyama; Ryoichi Hazama; Jinsong He; Hiroaki Kaji; Emi Kinoshita; Hisahide Nishio; Yumi Tohyama
Rab27b regulates c-kit expression by controlling the secretion of stem cell factor.
Shun-Ichi Nakamura; Hirohei Yamamura
Yasutomi Nishizuka: father of protein kinase C.

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2012: Takao Kashiwagi; Minoru Kishi; Satoshi Kusaka; Takao Mitsuhashi; Takuma Suzuki; Tamaki Hirata; Tadahiro Inagaki; Masahide Iwai; Naoki Yoshioka; Hirohei Yamamura
[Case report: family cases of datura poisoning].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2012;101(7):2045-7.
2012: Chisato Tanaka; Kaoru Tohyama; Takayuki Tsujioka; Hirohei Yamamura; Kunio Yokoyama; Ryoichi Hazama; Jinsong He; Hiroaki Kaji; Emi Kinoshita; Hisahide Nishio; Yumi Tohyama
Rab27b regulates c-kit expression by controlling the secretion of stem cell factor.
Biochemical and biophysical research communications 2012;419(2):368-73.
2010: Shun-Ichi Nakamura; Hirohei Yamamura
Yasutomi Nishizuka: father of protein kinase C.
Journal of biochemistry 2010;148(2):125-30.
2009: Ryoichi Hazama; Xiujuan Qu; Kunio Yokoyama; Chisato Tanaka; Emi Kinoshita; Jinsong He; Shusuke Takahashi; Kaoru Tohyama; Hirohei Yamamura; Yumi Tohyama
ATP-induced osteoclast function: the formation of sealing-zone like structure and the secretion of lytic granules via microtubule-deacetylation under the control of Syk.
Genes to cells : devoted to molecular & cellular mechanisms 2009;14(7):871-84.
2009: Yumi Tohyama; Hirohei Yamamura
Protein tyrosine kinase, syk: a key player in phagocytic cells.
Journal of biochemistry 2009;145(3):267-73.
2008: Sachiko Inubushi; Motoko Nagano-Fujii; Kikumi Kitayama; Motofumi Tanaka; Chunying An; Hiroshi Yokozaki; Hirohei Yamamura; Hideko Nuriya; Michinori Kohara; Kiyonao Sada; Hak Hotta
Hepatitis C virus NS5A protein interacts with and negatively regulates the non-receptor protein tyrosine kinase Syk.
The Journal of general virology 2008;89(Pt 5):1231-42.
2007: Chiseko Noda; Jinsong He; Tomoko Takano; Chisato Tanaka; Toshinori Kondo; Kaoru Tohyama; Hirohei Yamamura; Yumi Tohyama
Induction of apoptosis by epigallocatechin-3-gallate in human lymphoblastoid B cells.
Biochemical and biophysical research communications 2007;362(4):951-7.
2006: Ryo Yonashiro; Satoshi Ishido; Shinkou Kyo; Toshifumi Fukuda; Eiji Goto; Yohei Matsuki; Mari Ohmura-Hoshino; Kiyonao Sada; Hak Hotta; Hirohei Yamamura; Ryoko Inatome; Shigeru Yanagi
A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics.
The EMBO journal 2006;25(15):3618-26.
2006: Yuhong Shi; Yumi Tohyama; Tomomi Kadono; Jinsong He; S M Shahjahan Miah; Ryoichi Hazama; Chisato Tanaka; Kaoru Tohyama; Hirohei Yamamura
Protein-tyrosine kinase Syk is required for pathogen engulfment in complement-mediated phagocytosis.
Blood 2006;107(11):4554-62.
2006: Rina Kurihara; Yumi Tohyama; Satoshi Matsusaka; Hiromu Naruse; Emi Kinoshita; Takayuki Tsujioka; Yoshinao Katsumata; Hirohei Yamamura
Effects of peripheral cannabinoid receptor ligands on motility and polarization in neutrophil-like HL60 cells and human neutrophils.
The Journal of biological chemistry 2006;281(18):12908-18.
2006: Yumi Tohyama; Hirohei Yamamura
Complement-mediated phagocytosis--the role of Syk.
IUBMB life 2006;58(5-6):304-8.
2006: Qingyu Qin; Ryoko Inatome; Azusa Hotta; Masaki Kojima; Hirohei Yamamura; Hirokazu Hirai; Toshihiro Yoshizawa; Hirofumi Tanaka; Kiyoko Fukami; Shigeru Yanagi
A novel GTPase, CRAG, mediates promyelocytic leukemia protein-associated nuclear body formation and degradation of expanded polyglutamine protein.
The Journal of cell biology 2006;172(4):497-504.
2006: Hirohei Yamamura; Shun-Ichi Nakamura
Yasutomi Nishizuka: 12 July 1932 - 4 November 2004.
Biographical memoirs of fellows of the Royal Society. Royal Society (Great Britain) 2006;52():219-30.
2005: Xiujuan Qu; S M Shahjahan Miah; Tomoko Hatani; Mami Okazaki; Naoko Hori-Tamura; Hirohei Yamamura; Hak Hotta; Kiyonao Sada
Selective inhibition of Fcepsilon RI-mediated mast cell activation by a truncated variant of Cbl-b related to the rat model of type 1 diabetes mellitus.
Journal of biochemistry 2005;137(6):711-20.
2005: Satoshi Matsusaka; Yumi Tohyama; Jinsong He; Yuhong Shi; Ryoichi Hazama; Tomomi Kadono; Rina Kurihara; Kaoru Tohyama; Hirohei Yamamura
Protein-tyrosine kinase, Syk, is required for CXCL12-induced polarization of B cells.
Biochemical and biophysical research communications 2005;328(4):1163-9.
2005: Xiujuan Qu; Keiko Kawauchi-Kamata; S M Shahjahan Miah; Tomoko Hatani; Hirohei Yamamura; Kiyonao Sada
Tyrosine phosphorylation of adaptor protein 3BP2 induces T cell receptor-mediated activation of transcription factor.
Biochemistry 2005;44(10):3891-8.
2005: Jinsong He; Yumi Tohyama; Ken-ichi Yamamoto; Masahiko Kobayashi; Yuhong Shi; Tomoko Takano; Chiseko Noda; Kaoru Tohyama; Hirohei Yamamura
Lysosome is a primary organelle in B cell receptor-mediated apoptosis: an indispensable role of Syk in lysosomal function.
Genes to cells : devoted to molecular & cellular mechanisms 2005;10(1):23-35.
2005: Azusa Hotta; Ryoko Inatome; Junichi Yuasa-Kawada; Qingyu Qin; Hirohei Yamamura; Shigeru Yanagi
Critical role of collapsin response mediator protein-associated molecule CRAM for filopodia and growth cone development in neurons.
Molecular biology of the cell 2005;16(1):32-9.
2004: S M Shahjahan Miah; Tomoko Hatani; Xiujuan Qu; Hirohei Yamamura; Kiyonao Sada
Point mutations of 3BP2 identified in human-inherited disease cherubism result in the loss of function.
Genes to cells : devoted to molecular & cellular mechanisms 2004;9(11):993-1004.
2004: Masayuki Hirose; Jun Kitano; Yoshiaki Nakajima; Koki Moriyoshi; Shigeru Yanagi; Hirohei Yamamura; Takanori Muto; Hisato Jingami; Shigetada Nakanishi
Phosphorylation and recruitment of Syk by immunoreceptor tyrosine-based activation motif-based phosphorylation of tamalin.
The Journal of biological chemistry 2004;279(31):32308-15.
2004: Eisuke Enoki; Kiyonao Sada; Xiujuan Qu; Shinkou Kyo; S M Shahjahan Miah; Tomoko Hatani; Akio Tomoda; Hirohei Yamamura
The phenoxazine derivative Phx-1 suppresses IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 cells.
Journal of pharmacological sciences 2004;94(3):329-33.
2004: Xiujuan Qu; Kiyonao Sada; Shinkou Kyo; Koichiro Maeno; S M Shahjahan Miah; Hirohei Yamamura
Negative regulation of FcepsilonRI-mediated mast cell activation by a ubiquitin-protein ligase Cbl-b.
Blood 2004;103(5):1779-86.
2004: Yumi Tohyama; Tomoko Takano; Hirohei Yamamura
B cell responses to oxidative stress.
Current pharmaceutical design 2004;10(8):835-9.
2004: S M Shahjahan Miah; Kiyonao Sada; Polygena T Tuazon; Jun Ling; Koichiro Maeno; Shinkou Kyo; Xiujuan Qu; Yumi Tohyama; Jolinda A Traugh; Hirohei Yamamura
Activation of Syk protein tyrosine kinase in response to osmotic stress requires interaction with p21-activated protein kinase Pak2/gamma-PAK.
Molecular and cellular biology 2004;24(1):71-83.
2003: Shusuke Takahashi; Ryoko Inatome; Azusa Hotta; Qingyu Qin; Renee Hackenmiller; M Celeste Simon; Hirohei Yamamura; Shigeru Yanagi
Role for Fes/Fps tyrosine kinase in microtubule nucleation through is Fes/CIP4 homology domain.
The Journal of biological chemistry 2003;278(49):49129-33.
2003: Shinkou Kyo; Kiyonao Sada; Xiujuan Qu; Koichiro Maeno; S M Shahjahan Miah; Keiko Kawauchi-Kamata; Hirohei Yamamura
Negative regulation of Lyn protein-tyrosine kinase by c-Cbl ubiquitin-protein ligase in Fc epsilon RI-mediated mast cell activation.
Genes to cells : devoted to molecular & cellular mechanisms 2003;8(10):825-36.
2003: Koichiro Maeno; Kiyonao Sada; Shinkou Kyo; S M Shahjahan Miah; Keiko Kawauchi-Kamata; Xiujuan Qu; Yuhong Shi; Hirohei Yamamura
Adaptor protein 3BP2 is a potential ligand of Src homology 2 and 3 domains of Lyn protein-tyrosine kinase.
The Journal of biological chemistry 2003;278(27):24912-20.
2003: Shusuke Takahashi; Ryoko Inatome; Hirohei Yamamura; Shigeru Yanagi
Isolation and expression of a novel mitochondrial septin that interacts with CRMP/CRAM in the developing neurones.
Genes to cells : devoted to molecular & cellular mechanisms 2003;8(2):81-93.
2003: Kiyonao Sada; Hirohei Yamamura
Protein-tyrosine kinases and adaptor proteins in FcepsilonRI-mediated signaling in mast cells.
Current molecular medicine 2003;3(1):85-94.
2002: Sanyang Gao; Tomoko Takano; Kiyonao Sada; Jinsong He; Chiseko Noda; Naoko Hori-Tamura; Akio Tomoda; Hirohei Yamamura
A novel phenoxazine derivative suppresses surface IgM expression in DT40 B cell line.
British journal of pharmacology 2002;137(6):749-55.
2002: Chisato Mizutani; Yumi Tohyama; Yasuo Miura; Terutoshi Hishita; Toshio Nishihara; Hirohei Yamamura; Satoshi Ichiyama; Takashi Uchiyama; Kaoru Tohyama
Sustained activation of MEK1-ERK1/2 pathway in membrane skeleton occurs dependently on cell adhesion in megakaryocytic differentiation.
Biochemical and biophysical research communications 2002;297(3):664-71.
2002: Kiyonao Sada; S M Shahjahan Miah; Koichiro Maeno; Shinkou Kyo; Xiujuan Qu; Hirohei Yamamura
Regulation of FcepsilonRI-mediated degranulation by an adaptor protein 3BP2 in rat basophilic leukemia RBL-2H3 cells.
Blood 2002;100(6):2138-44.
2002: Norihiro Mitsui; Ryoko Inatome; Shusuke Takahashi; Yoshio Goshima; Hirohei Yamamura; Shigeru Yanagi
Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling.
The EMBO journal 2002;21(13):3274-85.
2002: Tomoko Takano; Kiyonao Sada; Hirohei Yamamura
Role of protein-tyrosine kinase syk in oxidative stress signaling in B cells.
Antioxidants & redox signaling 2002;4(3):533-41.
2002: Jinsong He; Tomoko Takano; Junyi Ding; Sanyang Gao; Chiseko Noda; Kiyonao Sada; Shigeru Yanagi; Hirohei Yamamura
Syk is required for p38 activation and G2/M arrest in B cells exposed to oxidative stress.
Antioxidants & redox signaling 2002;4(3):509-15.
2002: Hirohei Yamamura
Redox control of protein tyrosine phosphorylation.
Antioxidants & redox signaling 2002;4(3):479-80.
2002: Kenji Iwai; Isao Oishi; Xiao Zhou Xu; Yasuhiro Minami; Hirohei Yamamura
Physical interactions of Dmnk with Orb: implications in the regulated localization of Orb by Dmnk during oogenesis and embryogenesis.
Biochemical and biophysical research communications 2002;290(1):225-9.
2001: W Han; Tomoko Takano; Jinsong He; Junyi Ding; Sanyang Gao; Chiseko Noda; Shigeru Yanagi; Hirohei Yamamura
Role of BLNK in oxidative stress signaling in B cells.
Antioxidants & redox signaling 2001;3(6):1065-73.
2001: Shigeru Yanagi; Ryoko Inatome; Tomoko Takano; Hirohei Yamamura
Syk expression and novel function in a wide variety of tissues.
Biochemical and biophysical research communications 2001;288(3):495-8.
2001: Shigeru Yanagi; Ryoko Inatome; Junyi Ding; H Kitaguchi; V L Tybulewicz; Hirohei Yamamura
Syk expression in endothelial cells and their morphologic defects in embryonic Syk-deficient mice.
Blood 2001;98(9):2869-71.
2001: Yasuo Miura; Chisato Mizutani; Toshio Nishihara; Terutoshi Hishita; S Yanagi; Yumi Tohyama; Satoshi Ichiyama; Hirohei Yamamura; Takashi Uchiyama; Kaoru Tohyama
Adhesion via CD43 induces Syk activation and cell proliferation in TF-1 cells.
Biochemical and biophysical research communications 2001;288(1):80-6.
2001: Ryoko Inatome; Shigeru Yanagi; Tomoko Takano; Hirohei Yamamura
A critical role for Syk in endothelial cell proliferation and migration.
Biochemical and biophysical research communications 2001;286(1):195-9.
2001: Kiyonao Sada; Tomoko Takano; Shigeru Yanagi; Hirohei Yamamura
Structure and function of Syk protein-tyrosine kinase.
Journal of biochemistry 2001;130(2):177-86.
2001: Takechiyo Yamada; Shigeharu Fujieda; Shigeru Yanagi; Hirohei Yamamura; Ryoko Inatome; Hideyuki Yamamoto; Hideki Igawa; Hitoshi Saito
IL-1 induced chemokine production through the association of Syk with TNF receptor-associated factor-6 in nasal fibroblast lines.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(1):283-8.
2001: Tomohiro Hitomi; Shigeru Yanagi; Ryoko Inatome; Junyi Ding; Tomoko Takano; Hirohei Yamamura
Requirement of Syk-phospholipase C-gamma2 pathway for phorbol ester-induced phospholipase D activation in DT40 cells.
Genes to cells : devoted to molecular & cellular mechanisms 2001;6(5):475-85.
2001: Hiroko Fujimoto; Y Tanaka; Zhao-Jun Liu; Hideo Yagita; K Okumura; Atsushi Kosugi; Akio Morinobu; H Umehara; Hirohei Yamamura; Yasuhiro Minami
Down-regulation of alpha6 integrin, an anti-oncogene product, by functional cooperation of H-Ras and c-Myc.
Genes to cells : devoted to molecular & cellular mechanisms 2001;6(4):337-43.
2001: T Tsujimura; Shigeru Yanagi; Ryoko Inatome; Tomoko Takano; I Ishihara; Norihiro Mitsui; Shusuke Takahashi; Hirohei Yamamura
Syk protein-tyrosine kinase is involved in neuron-like differentiation of embryonal carcinoma P19 cells.
FEBS letters 2001;489(2-3):129-33.
2001: Isao Oishi; Kenji Iwai; Y Kagohashi; Hiroko Fujimoto; Ken-Ichi Kariya; Tohru Kataoka; Hitoshi Sawa; Hideyuki Okano; H Otani; Hirohei Yamamura; Yasuhiro Minami
Critical role of Caenorhabditis elegans homologs of Cds1 (Chk2)-related kinases in meiotic recombination.
Molecular and cellular biology 2001;21(4):1329-35.
2001: Takechiyo Yamada; Shigeharu Fujieda; Shigeru Yanagi; Hirohei Yamamura; Ryoko Inatome; Hiroshi Sunaga; Hitoshi Saito
Protein-tyrosine kinase Syk expressed in human nasal fibroblasts and its effect on RANTES production.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(1):538-43.
2000: Junyi Ding; Tomoko Takano; Sanyang Gao; W Han; Chiseko Noda; Shigeru Yanagi; Hirohei Yamamura
Syk is required for the activation of Akt survival pathway in B cells exposed to oxidative stress.
The Journal of biological chemistry 2000;275(40):30873-7.
2000: Yasuo Miura; Yumi Tohyama; Terutoshi Hishita; A Lala; Ernesto De Nardin; Yoshihiro Yoshida; Hirohei Yamamura; Takashi Uchiyama; Kaoru Tohyama
Pyk2 and Syk participate in functional activation of granulocytic HL-60 cells in a different manner.
Blood 2000;96(5):1733-9.
2000: Ryoko Inatome; T Tsujimura; Tomohiro Hitomi; Norihiro Mitsui; P Hermann; Shun'ichi Kuroda; Hirohei Yamamura; Shigeru Yanagi
Identification of CRAM, a novel unc-33 gene family protein that associates with CRMP3 and protein-tyrosine kinase(s) in the developing rat brain.
The Journal of biological chemistry 2000;275(35):27291-302.
2000: Junyi Ding; Tomoko Takano; P Hermann; Sanyang Gao; W Han; Chiseko Noda; Shigeru Yanagi; Hirohei Yamamura
Distinctive functions of Syk N-terminal and C-terminal SH2 domains in the signaling cascade elicited by oxidative stress in B cells.
Journal of biochemistry 2000;127(5):791-6.
2000: S Tsuchida; Shigeru Yanagi; Ryoko Inatome; Junyi Ding; P Hermann; T Tsujimura; N Matsui; Hirohei Yamamura
Purification of a 72-kDa protein-tyrosine kinase from rat liver and its identification as Syk: involvement of Syk in signaling events of hepatocytes.
Journal of biochemistry 2000;127(2):321-7.
2000: I Ishihara; Yasuhiro Minami; Tomoyuki Nishizaki; T Matsuoka; Hirohei Yamamura
Activation of calpain precedes morphological alterations during hydrogen peroxide-induced apoptosis in neuronally differentiated mouse embryonal carcinoma P19 cell line.
Neuroscience letters 2000;279(2):97-100.
2000: S Takeuchi; Kohsuke Takeda; Isao Oishi; M Nomi; M Ikeya; K Itoh; S Tamura; T Ueda; T Hatta; H Otani; T Terashima; Shinji Takada; Hirohei Yamamura; Shizuo Akira; Yasuhiro Minami
Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation.
Genes to cells : devoted to molecular & cellular mechanisms 2000;5(1):71-8.
1999: T Ueda; H Sakagami; K Abe; Isao Oishi; Ayako Maruo; H Kondo; T Terashima; M Ichihashi; Hirohei Yamamura; Yasuhiro Minami
Distribution and intracellular localization of a mouse homologue of Ca2+/calmodulin-dependent protein kinase Ibeta2 in the nervous system.
Journal of neurochemistry 1999;73(5):2119-29.
1999: Zhao-Jun Liu; Y Tanaka; Hiroko Fujimoto; S Mine; Akio Morinobu; Hideo Yagita; K Okumura; Isao Oishi; J Udagawa; Hirohei Yamamura; Yasuhiro Minami
A novel role for H-Ras in the regulation of very late antigen-4 integrin and VCAM-1 via c-Myc-dependent and -independent mechanisms.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(9):4901-8.
1999: Ayako Maruo; Isao Oishi; K Sada; M Nomi; T Kurosaki; Yasuhiro Minami; Hirohei Yamamura
Protein tyrosine kinase Lyn mediates apoptosis induced by topoisomerase II inhibitors in DT40 cells.
International immunology 1999;11(9):1371-80.
1999: S Qin; Junyi Ding; Tomoko Takano; Hirohei Yamamura
Involvement of receptor aggregation and reactive oxygen species in osmotic stress-induced Syk activation in B cells.
Biochemical and biophysical research communications 1999;262(1):231-6.
1999: Tomohiro Hitomi; Shigeru Yanagi; Ryoko Inatome; Hirohei Yamamura
Cross-linking of the B cell receptor induces activation of phospholipase D through Syk, Btk and phospholipase C-gamma2.
FEBS letters 1999;445(2-3):371-4.
1999: Isao Oishi; S Takeuchi; R Hashimoto; A Nagabukuro; T Ueda; Zhao-Jun Liu; T Hatta; Shizuo Akira; Y Matsuda; Hirohei Yamamura; H Otani; Yasuhiro Minami
Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system.
Genes to cells : devoted to molecular & cellular mechanisms 1999;4(1):41-56.
1998: Zhao-Jun Liu; Y Tanaka; S Mine; Akio Morinobu; Hideo Yagita; K Okumura; T Taniguchi; Hirohei Yamamura; Yasuhiro Minami
Functional cooperation of cyclin C and c-Myc in mediating homotypic cell adhesion via very late antigen-4 activation and vascular cell adhesion molecule-1 induction.
Blood 1998;92(12):4700-11.
1998: Yumi Tohyama; Kaoru Tohyama; M Tsubokawa; M Asahi; Y Yoshida; Hirohei Yamamura
Outside-In signaling of soluble and solid-phase fibrinogen through integrin alphaIIbbeta3 is different and cooperative with each other in a megakaryoblastic leukemia cell line, CMK.
Blood 1998;92(4):1277-86.
1998: Zhao-Jun Liu; T Ueda; T Miyazaki; N Tanaka; S Mine; Y Tanaka; T Taniguchi; Hirohei Yamamura; Yasuhiro Minami
A critical role for cyclin C in promotion of the hematopoietic cell cycle by cooperation with c-Myc.
Molecular and cellular biology 1998;18(6):3445-54.
1998: K Rezaul; Kiyonao Sada; Hirohei Yamamura
Involvement of reactive oxygen intermediates in lectin-induced protein-tyrosine phosphorylation of Syk in THP-1 cells.
Biochemical and biophysical research communications 1998;246(3):863-7.
1998: S Qin; Junyi Ding; T Kurosaki; Hirohei Yamamura
A deficiency in Syk enhances ceramide-induced apoptosis in DT40 lymphoma B cells.
FEBS letters 1998;427(1):139-43.
1998: S Qin; T Kurosaki; Hirohei Yamamura
Differential regulation of oxidative and osmotic stress induced Syk activation by both autophosphorylation and SH2 domains.
Biochemistry 1998;37(16):5481-6.
1998: H Yoneya; Shigeru Yanagi; Ryoko Inatome; Junyi Ding; Tomohiro Hitomi; Mutsuo Amatsu; Hirohei Yamamura
Antibodies directed against ZAP-70 cross-react with a 66 kDa tyrosine kinase in the rat brain.
Biochemical and biophysical research communications 1998;245(1):140-3.
1998: Isao Oishi; S Sugiyama; H Otani; Hirohei Yamamura; Y Nishida; Yasuhiro Minami
A novel Drosophila nuclear protein serine/threonine kinase expressed in the germline during its establishment.
Mechanisms of development 1998;71(1-2):49-63.
1998: Kiyonao Sada; Hirohei Yamamura
Effect of lectins on protein kinase activity.
Methods in molecular medicine 1998;9():423-32.
1997: M Tsubokawa; Yumi Tohyama; Kaoru Tohyama; M Asahi; T Inazu; H Nakamura; Hitoshi Saito; Hirohei Yamamura
Interleukin-3 activates Syk in a human myeloblastic leukemia cell line, AML193.
European journal of biochemistry / FEBS 1997;249(3):792-6.
1997: K Rezaul; Kiyonao Sada; T Inazu; Hirohei Yamamura
Platelet-activating factor stimulates calcium-dependent activation of protein-tyrosine kinase Syk in a human B cell line.
Biochemical and biophysical research communications 1997;239(1):23-7.
1997: Kiyonao Sada; Yasuhiro Minami; Hirohei Yamamura
Relocation of Syk protein-tyrosine kinase to the actin filament network and subsequent association with Fak.
European journal of biochemistry / FEBS 1997;248(3):827-33.
1997: S Qin; Hirohei Yamamura
Up-regulation of Syk activity during HL60 cell differentiation into granulocyte but not into monocyte/macrophage-lineage.
Biochemical and biophysical research communications 1997;236(3):697-701.
1997: S Qin; Yasuhiro Minami; T Kurosaki; Hirohei Yamamura
Distinctive functions of Syk and Lyn in mediating osmotic stress- and ultraviolet C irradiation-induced apoptosis in chicken B cells.
The Journal of biological chemistry 1997;272(29):17994-9.
1997: Isao Oishi; S Sugiyama; Zhao-Jun Liu; Hirohei Yamamura; Y Nishida; Yasuhiro Minami
A novel Drosophila receptor tyrosine kinase expressed specifically in the nervous system. Unique structural features and implication in developmental signaling.
The Journal of biological chemistry 1997;272(18):11916-23.
1997: N Ueno; Isao Oishi; Shigeru Sugiyama; Y Nishida; Yasuhiro Minami; Hirohei Yamamura
Identification of a novel Drosophila protein kinase highly homologous to protein kinase N (PKN).
Biochemical and biophysical research communications 1997;232(1):126-9.
1997: X Wang; Shigeru Yanagi; C Yang; Ryoko Inatome; Hirohei Yamamura
Tyrosine phosphorylation and Syk activation are involved in thrombin-induced aggregation of epinephrine-potentiated platelets.
Journal of biochemistry 1997;121(2):325-30.
1997: S Qin; Yasuhiro Minami; Masahiko Hibi; T Kurosaki; Hirohei Yamamura
Syk-dependent and -independent signaling cascades in B cells elicited by osmotic and oxidative stress.
The Journal of biological chemistry 1997;272(4):2098-103.
1996: Yasuhiro Minami; Kiyonao Sada; Isao Oishi; Hirohei Yamamura
[Roles of protein tyrosine kinases in activation, proliferation and apoptosis of immuno-hematopoietic cells].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1996;41(12 Suppl):1666-72.
1996: S Maruyama; T Kurosaki; Kiyonao Sada; Y Yamanashi; T Yamamoto; Hirohei Yamamura
Physical and functional association of cortactin with Syk in human leukemic cell line K562.
The Journal of biological chemistry 1996;271(12):6631-5.
1996: S Qin; T Inazu; M Takata; T Kurosaki; Y Homma; Hirohei Yamamura
Cooperation of tyrosine kinases p72syk and p53/56lyn regulates calcium mobilization in chicken B cell oxidant stress signaling.
European journal of biochemistry / FEBS 1996;236(2):443-9.
1995: E Hashimoto; F Takeuchi; Y Tanaka; Hirohei Yamamura
Purification and phosphorylation of a M(r) 25,000 protein, an effective phosphate acceptor for casein kinase II and protein kinase C, detected in the cytosolic fraction of Xenopus laevis oocytes.
Journal of biochemistry 1995;118(2):453-60.
1995: M Asahi; Y Tanaka; S Qin; M Tsubokawa; Kiyonao Sada; Yasuhiro Minami; Hirohei Yamamura
Cyclic AMP-elevating agents negatively regulate the activation of p72syk in N-formyl-methionyl-leucyl-phenylalanine receptor signaling.
Biochemical and biophysical research communications 1995;212(3):887-93.
1995: C Yang; S Maruyama; S Yanagi; X Wang; M Takata; T Kurosaki; Hirohei Yamamura
Syk and Lyn are involved in radiation-induced signaling, but inactivation of Syk or Lyn alone is not sufficient to prevent radiation-induced apoptosis.
Journal of biochemistry 1995;118(1):33-8.
1995: H Maeda; T Inazu; K Nagai; S Maruyama; G Nakagawara; Hirohei Yamamura
Possible involvement of protein-tyrosine kinases such as p72syk in the disc-sphere change response of porcine platelets.
Journal of biochemistry 1995;117(6):1201-8.
1995: S Qin; T Inazu; Hirohei Yamamura
Activation and tyrosine phosphorylation of p72syk as well as calcium mobilization after hydrogen peroxide stimulation in peripheral blood lymphocytes.
The Biochemical journal 1995;308 ( Pt 1)():347-52.
1995: K Nagai; M Takata; Hirohei Yamamura; T Kurosaki
Tyrosine phosphorylation of Shc is mediated through Lyn and Syk in B cell receptor signaling.
The Journal of biological chemistry 1995;270(12):6824-9.
1995: S Yanagi; T Kurosaki; Hirohei Yamamura
The structure and function of nonreceptor tyrosine kinase p72syk expressed in hematopoietic cells.
Cellular signalling 1995;7(3):185-93.
1994: Yumi Tohyama; S Yanagi; Kiyonao Sada; Hirohei Yamamura
Translocation of p72syk to the cytoskeleton in thrombin-stimulated platelets.
The Journal of biological chemistry 1994;269(52):32796-9.
1994: H Shimizu; H Takayama; J D Lee; K Satake; Takanobu Taniguchi; Hirohei Yamamura; T Nakamura
Effects of vanadate on prostacyclin and endothelin-1 production and protein-tyrosine phosphorylation in human endothelial cells.
Thrombosis and haemostasis 1994;72(6):973-8.
1994: K Rezaul; S Yanagi; Kiyonao Sada; T Taniguchi; Hirohei Yamamura
Protein-tyrosine kinase p72syk is activated by platelet activating factor in platelets.
Thrombosis and haemostasis 1994;72(6):937-41.
1994: C Fujii; S Yanagi; Kiyonao Sada; K Nagai; Takanobu Taniguchi; Hirohei Yamamura
Involvement of protein-tyrosine kinase p72syk in collagen-induced signal transduction in platelets.
European journal of biochemistry / FEBS 1994;226(1):243-8.
1994: K Nagai; T Inazu; Hirohei Yamamura
p72syk is activated by vanadate plus H2O2 in porcine platelets and phosphorylates GTPase activating protein on tyrosine residue(s).
Journal of biochemistry 1994;116(5):1176-81.
1994: X Wang; Kiyonao Sada; S Yanagi; C Yang; K Rezaul; Hirohei Yamamura
Intracellular calcium dependent activation of p72syk in platelets.
Journal of biochemistry 1994;116(4):858-61.
1994: S Yanagi; Kiyonao Sada; Hirohei Yamamura
[The structure and function of novel protein-tyrosine kinase p72syk expressed in hematopoietic cells].
Seikagaku. The Journal of Japanese Biochemical Society 1994;66(9):1219-29.
1994: S Yanagi; Kiyonao Sada; Yumi Tohyama; M Tsubokawa; K Nagai; K Yonezawa; Hirohei Yamamura
Translocation, activation and association of protein-tyrosine kinase (p72syk) with phosphatidylinositol 3-kinase are early events during platelet activation.
European journal of biochemistry / FEBS 1994;224(2):329-33.
1994: S Qin; T Inazu; C Yang; Kiyonao Sada; Takanobu Taniguchi; Hirohei Yamamura
Interleukin 2 mediates p72syk activation in peripheral blood lymphocytes.
FEBS letters 1994;345(2-3):233-6.
1994: M Tsubokawa; S Yanagi; Kiyonao Sada; S Nakamura; H Saito; Hirohei Yamamura
CPTK71, a cytosolic protein-tyrosine kinase previously purified from bovine platelets, is identical with p72syk.
Biochemical and biophysical research communications 1994;200(3):1592-7.
1994: C Yang; S Yanagi; X Wang; K Sakai; Takanobu Taniguchi; Hirohei Yamamura
Purification and characterization of a protein-tyrosine kinase p72syk from porcine spleen.
European journal of biochemistry / FEBS 1994;221(3):973-8.
1994: Kiyonao Sada; S Yanagi; Hirohei Yamamura
Activation of p72syk by thrombin in a cell-free system.
Biochemical and biophysical research communications 1994;200(1):1-7.
1993: H Maeda; Takanobu Taniguchi; T Inazu; C Yang; G Nakagawara; Hirohei Yamamura
Protein-tyrosine kinase p72syk is activated by thromboxane A2 mimetic U44069 in platelets.
Biochemical and biophysical research communications 1993;197(1):62-7.
1993: M Asahi; Takanobu Taniguchi; E Hashimoto; T Inazu; H Maeda; Hirohei Yamamura
Activation of protein-tyrosine kinase p72syk with concanavalin A in polymorphonuclear neutrophils.
The Journal of biological chemistry 1993;268(31):23334-8.
1993: N Takeuchi; E Hashimoto; T Nakamura; F Takeuchi; Kiyonao Sada; Hirohei Yamamura
Possible role of Na+ influx in phorbol ester-induced down-regulation of protein kinase C in HL60 cells.
FEBS letters 1993;328(3):280-4.
1993: F Takeuchi; Takanobu Taniguchi; H Maeda; C Fujii; N Takeuchi; Hirohei Yamamura
The lectin concanavalin A stimulates a protein-tyrosine kinase p72syk in peripheral blood lymphocytes.
Biochemical and biophysical research communications 1993;194(1):91-6.
1993: R Shimomura; K Sakai; Y Tanaka; K Yonezawa; E Hashimoto; M Kasuga; Hirohei Yamamura
Phosphorylation sites of myelin basic protein by a catalytic fragment of non-receptor type protein-tyrosine kinase p72syk and comparison with those by insulin receptor kinase.
Biochemical and biophysical research communications 1993;192(1):252-60.
1993: T Yamada; Takanobu Taniguchi; C Yang; S Yasue; H Saito; Hirohei Yamamura
Association with B-cell-antigen receptor with protein-tyrosine kinase p72syk and activation by engagement of membrane IgM.
European journal of biochemistry / FEBS 1993;213(1):455-9.
1993: Takanobu Taniguchi; H Kitagawa; S Yasue; S Yanagi; K Sakai; M Asahi; S Ohta; F Takeuchi; S Nakamura; Hirohei Yamamura
Protein-tyrosine kinase p72syk is activated by thrombin and is negatively regulated through Ca2+ mobilization in platelets.
The Journal of biological chemistry 1993;268(4):2277-9.
1992: N Takeuchi; T Nakamura; F Takeuchi; E Hashimoto; Hirohei Yamamura
Inhibitory effect of mitoxantrone on activity of protein kinase C and growth of HL60 cells.
Journal of biochemistry 1992;112(6):762-7.
1992: M Asahi; S Yanagi; S Ohta; T Inazu; K Sakai; F Takeuchi; Takanobu Taniguchi; Hirohei Yamamura
Thrombin-induced human platelet aggregation is inhibited by protein-tyrosine kinase inhibitors, ST638 and genistein.
FEBS letters 1992;309(1):10-4.
1992: S Ohta; Takanobu Taniguchi; M Asahi; Y Kato; G Nakagawara; Hirohei Yamamura
Protein-tyrosine kinase p72syk is activated by wheat germ agglutinin in platelets.
Biochemical and biophysical research communications 1992;185(3):1128-32.
1992: S Ohta; T Inazu; Takanobu Taniguchi; G Nakagawara; Hirohei Yamamura
Protein-tyrosine phosphorylations induced by concanavalin A and N-formyl-methionyl-leucyl-phenylalanine in human neutrophils.
European journal of biochemistry / FEBS 1992;206(3):895-900.
1992: F Takeuchi; E Hashimoto; Hirohei Yamamura
Phosphorylation of histone H2A by protein kinase C and identification of the phosphorylation site.
Journal of biochemistry 1992;111(6):788-92.
1991: K Sakai; Y Tanaka; M Asahi; R Shimomura; Takanobu Taniguchi; E Hashimoto; Hirohei Yamamura
Identification of the phosphorylation sites of H2B histone by a catalytic fragment of p72syk from porcine spleen.
FEBS letters 1991;294(1-2):104-8.
1991: T Yamada; Takanobu Taniguchi; K Nagai; H Saitoh; Hirohei Yamamura
The lectin wheat germ agglutinin stimulates a protein-tyrosine kinase activity of p72syk in porcine splenocytes.
Biochemical and biophysical research communications 1991;180(3):1325-9.
1991: Takanobu Taniguchi; T Kobayashi; J Kondo; K Takahashi; H Nakamura; Jinya Suzuki; K Nagai; T Yamada; S Nakamura; Hirohei Yamamura
Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis.
The Journal of biological chemistry 1991;266(24):15790-6.
1991: T Inazu; Takanobu Taniguchi; S Ohta; S Miyabo; Hirohei Yamamura
The lectin wheat germ agglutinin induces rapid protein-tyrosine phosphorylation in human platelets.
Biochemical and biophysical research communications 1991;174(3):1154-8.
1991: H Takayama; T Nakamura; S Yanagi; Takanobu Taniguchi; S Nakamura; Hirohei Yamamura
Ionophore A23187-induced protein-tyrosine phosphorylation of human platelets: possible synergism between Ca2+ mobilization and protein kinase C activation.
Biochemical and biophysical research communications 1991;174(2):922-7.
1991: E Hashimoto; Hirohei Yamamura
Protease-activated protein kinase C in rat liver.
The International journal of biochemistry 1991;23(5-6):507-12.
1991: E Hashimoto; F Takeuchi; Hirohei Yamamura
Studies on protein kinase C tightly-bound to rat liver plasma membrane and its protease-activated form.
The International journal of biochemistry 1991;23(4):395-403.
1991: R Shimomura; Takanobu Taniguchi; K Sakai; M Asahi; T Inazu; Hirohei Yamamura
Possible endogenous substrate proteins for cytosolic protein-tyrosine kinase from porcine spleen.
The International journal of biochemistry 1991;23(7-8):727-31.
1990: E Hashimoto; F Takeuchi; Hirohei Yamamura
Protease-activated form of protein kinase C with Mr 80,000 generated from rat liver plasma membrane by trypsin-like protease.
Biochemistry international 1990;21(5):949-57.
1990: T Inazu; Takanobu Taniguchi; S Yanagi; Hirohei Yamamura
Protein-tyrosine phosphorylation and aggregation of intact human platelets by vanadate with H2O2.
Biochemical and biophysical research communications 1990;170(1):259-63.
1990: T Kobayashi; S Nakamura; Takanobu Taniguchi; Hirohei Yamamura
Purification and characterization of a cytosolic protein-tyrosine kinase from porcine spleen.
European journal of biochemistry / FEBS 1990;188(3):535-40.
1990: M Asahi; Takanobu Taniguchi; K Sakai; S Nakamura; Hirohei Yamamura
Diverse effects of poly-basic amino acids, heparin and ionic strength on the phosphorylation of various substrates by cytosolic protein-tyrosine kinase from porcine spleen.
The International journal of biochemistry 1990;22(6):635-40.
1990: E Hashimoto; Hirohei Yamamura
Comparison of substrate recognition by protein kinase C (type III) between rat liver cytosolic and particulate fractions.
The International journal of biochemistry 1990;22(4):405-10.
1990: E Hashimoto; Y Tanaka; Hirohei Yamamura
Mechanism of proteolytic activation of rat liver protein kinase C generating Ca2(+)-phospholipid-independent form with apparent molecular mass of 80,000.
The International journal of biochemistry 1990;22(8):865-71.
1989: K Sakai; Takanobu Taniguchi; R Shimomura; M Asahi; T Kobayashi; T Inazu; S Nakamura; Hirohei Yamamura
Phospholipids differently modulate the activity of cytosolic protein-tyrosine kinase from porcine spleen.
Biochemical and biophysical research communications 1989;165(2):680-4.
1989: E Hashimoto; Hirohei Yamamura
Further studies on the ionic strength-dependent proteolytic activation of protein kinase C in rat liver plasma membrane by endogenous trypsin-like protease.
Journal of biochemistry 1989;106(6):1041-8.
1989: M Kawata; Akira Kikuchi; M Hoshijima; K Yamamoto; E Hashimoto; Hirohei Yamamura; Yoshimi Takai
Phosphorylation of smg p21, a ras p21-like GTP-binding protein, by cyclic AMP-dependent protein kinase in a cell-free system and in response to prostaglandin E1 in intact human platelets.
The Journal of biological chemistry 1989;264(26):15688-95.
1989: S Nakamura; Hirohei Yamamura
Thrombin and collagen induce rapid phosphorylation of a common set of cellular proteins on tyrosine in human platelets.
The Journal of biological chemistry 1989;264(13):7089-91.
1989: E Hashimoto; Hirohei Yamamura
Ionic strength-dependent interaction of rat liver casein kinase I with plasma membrane.
Biochemical and biophysical research communications 1989;160(2):633-7.
1989: K Sakai; M Asahi; T Kobayashi; Y Tanaka; T Inazu; S Nakamura; Hirohei Yamamura
Effect of poly-basic amino acids on the phosphorylation of various substrate proteins by cytosolic protein-tyrosine kinase from porcine spleen.
Biochemical and biophysical research communications 1989;158(3):1043-9.
1988: M Hoshijima; Akira Kikuchi; M Kawata; T Ohmori; E Hashimoto; Hirohei Yamamura; Yoshimi Takai
Phosphorylation by cyclic AMP-dependent protein kinase of a human platelet Mr 22,000 GTP-binding protein (smg p21) having the same putative effector domain as the ras gene products.
Biochemical and biophysical research communications 1988;157(3):851-60.
1988: E Hashimoto; K Mizuta; Y Sakanoue; Hirohei Yamamura
Ionic strength-dependent proteolytic activation of protein kinase C by trypsin-like protease.
Journal of biochemistry 1988;104(6):934-8.
1988: K Sakai; Kiyonao Sada; Y Tanaka; T Kobayashi; S Nakamura; Hirohei Yamamura
Regulation of cytosolic protein-tyrosine kinase from porcine spleen by polyamines and negative-charged polysaccharides.
Biochemical and biophysical research communications 1988;154(3):883-9.
1988: K Nishiyama; K Sakai; Y Tanaka; T Kobayashi; S Nakamura; Y Sakanoue; E Hashimoto; Hirohei Yamamura
Comparison of phosphorylation sites in protamines between protein kinase C and cAMP-dependent protein kinase.
Biochemistry international 1988;17(1):51-8.
1988: S Nakamura; S Yanagi; Hirohei Yamamura
Purification and characterization of cytosolic protein-tyrosine kinase from bovine platelets.
European journal of biochemistry / FEBS 1988;174(3):471-7.
1988: K Sakai; S Nakamura; Kiyonao Sada; T Kobayashi; H Uno; Hirohei Yamamura
Characterization of partially purified cytosolic protein-tyrosine kinase from porcine spleen.
Biochemical and biophysical research communications 1988;152(3):1123-30.
1988: S Nakamura; T Kobayashi; S Yanagi; Hirohei Yamamura
Protein phosphorylation and activation of human platelets by sodium fluoride.
Biochemical and biophysical research communications 1988;151(1):242-7.
1988: Y Sakanoue; E Hashimoto; S Nakamura; Hirohei Yamamura
Insulin-stimulated serine kinase in Xenopus oocyte plasma membrane.
Biochemical and biophysical research communications 1988;150(3):1176-84.
1987: Y Sakanoue; E Hashimoto; K Mizuta; H Kondo; Hirohei Yamamura
Comparative studies on phosphorylation of synthetic peptide analogue of ribosomal protein S6 and 40-S ribosomal subunits between Ca2+/phospholipid-dependent protein kinase and its protease-activated form.
European journal of biochemistry / FEBS 1987;168(3):669-77.