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Masakatsu Yamashita

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Junpei Suzuki; Soichi Tofukuji; Masashi Imamura; Fuminori Kato; Makoto Kuwahara; Toshinori Nakayama; Osamu Ohara; Masakatsu Yamashita
A Novel Small Compound SH-2251 Suppresses Th2 Cell-Dependent Airway Inflammation through Selective Modulation of Chromatin Status at the Il5 Gene Locus.
Makoto Kuwahara; Veronique Lefebvre; Shinichiro Motohashi; Atsushi Onodera; Ryo Shinnakasu; Kenta Shinoda; Soichi Tofukuji; Damon Tumes; Masakatsu Yamashita; Hiroyuki Hosokawa; Chiaki Iwamura; Toshinori Nakayama
The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses T(H)2 differentiation.
Soichi Tofukuji; Makoto Kuwahara; Toshinori Nakayama; Osamu Ohara; Junpei Suzuki; Masakatsu Yamashita
Identification of a new pathway for Th1 cell development induced by cooperative stimulation with IL-4 and TGF-β.

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2013: Junpei Suzuki; Soichi Tofukuji; Masashi Imamura; Fuminori Kato; Makoto Kuwahara; Toshinori Nakayama; Osamu Ohara; Masakatsu Yamashita
A Novel Small Compound SH-2251 Suppresses Th2 Cell-Dependent Airway Inflammation through Selective Modulation of Chromatin Status at the Il5 Gene Locus.
PloS one 2013;8(4):e61785.
2012: Makoto Kuwahara; Veronique Lefebvre; Shinichiro Motohashi; Atsushi Onodera; Ryo Shinnakasu; Kenta Shinoda; Soichi Tofukuji; Damon Tumes; Masakatsu Yamashita; Hiroyuki Hosokawa; Chiaki Iwamura; Toshinori Nakayama
The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses T(H)2 differentiation.
Nature immunology 2012;13(8):778-86.
2012: Soichi Tofukuji; Makoto Kuwahara; Toshinori Nakayama; Osamu Ohara; Junpei Suzuki; Masakatsu Yamashita
Identification of a new pathway for Th1 cell development induced by cooperative stimulation with IL-4 and TGF-β.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(10):4846-57.
2011: Yusuke Endo; Hiroyuki Hosokawa; Chiaki Iwamura; Makoto Kuwahara; Kaoru Sugaya; Akane Suzuki; Koji Tokoyoda; Damon J Tumes; Masakatsu Yamashita; Toshinori Nakayama
Eomesodermin controls interleukin-5 production in memory T helper 2 cells through inhibition of activity of the transcription factor GATA3.
Immunity 2011;35(5):733-45.
2011: Yoshiro Hirasaki; Chiaki Iwamura; Masakatsu Yamashita; Toshihiro Ito; Masayuki Kitajima; Kenta Shinoda; Takao Namiki; Katsutoshi Terasawa; Toshinori Nakayama
Repressor of GATA negatively regulates murine contact hypersensitivity through the inhibition of type-2 allergic responses.
Clinical immunology (Orlando, Fla.) 2011;139(3):267-76.
2010: Kohsuke Okita; Shinichiro Motohashi; Ryo Shinnakasu; Kaoru Nagato; Kazuki Yamasaki; Yasunori Sato; Hiroshi Kitamura; Atsushi Hijikata; Masakatsu Yamashita; Kanako Shimizu; Shin-Ichiro Fujii; Osamu Ohara; Masaru Taniguchi; Isao Sakaida; Toshinori Nakayama
A set of genes associated with the interferon-γ response of lung cancer patients undergoing α-galactosylceramide-pulsed dendritic cell therapy.
Cancer science 2010;101(11):2333-40.
2010: Atsushi Onodera; Masakatsu Yamashita; Yusuke Endo; Makoto Kuwahara; Soichi Tofukuji; Hiroyuki Hosokawa; Akinori Kanai; Yutaka Suzuki; Toshinori Nakayama
STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells.
The Journal of experimental medicine 2010;207(11):2493-506.
2010: Toshinori Nakayama; Masakatsu Yamashita
The TCR-mediated signaling pathways that control the direction of helper T cell differentiation.
Seminars in immunology 2010;22(5):303-9.
2010: Akane Suzuki; Chiaki Iwamura; Kenta Shinoda; Damon J Tumes; Motoko Y Kimura; Hiroyuki Hosokawa; Yusuke Endo; Shu Horiuchi; Koji Tokoyoda; Haruhiko Koseki; Masakatsu Yamashita; Toshinori Nakayama
Polycomb group gene product Ring1B regulates Th2-driven airway inflammation through the inhibition of Bim-mediated apoptosis of effector Th2 cells in the lung.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(8):4510-20.
2009: Takako Miki-Hosokawa; Akihiro Hasegawa; Chiaki Iwamura; Kenta Shinoda; Soichi Tofukuji; Yukiko Watanabe; Hiroyuki Hosokawa; Shinichiro Motohashi; Kahoko Hashimoto; Mutsunori Shirai; Masakatsu Yamashita; Toshinori Nakayama
CD69 controls the pathogenesis of allergic airway inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(12):8203-15.
2009: Masayuki Kitajima; Chiaki Iwamura; Takako Miki-Hosokawa; Kenta Shinoda; Yusuke Endo; Yukiko Watanabe; Ryo Shinnakasu; Hiroyuki Hosokawa; Kahoko Hashimoto; Shinichiro Motohashi; Haruhiko Koseki; Osamu Ohara; Masakatsu Yamashita; Toshinori Nakayama
Enhanced Th2 cell differentiation and allergen-induced airway inflammation in Zfp35-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(8):5388-96.
2009: Toshinori Nakayama; Masakatsu Yamashita
Critical role of the Polycomb and Trithorax complexes in the maintenance of CD4 T cell memory.
Seminars in immunology 2009;21(2):78-83.
2008: Mohammad B Hossain; Hiroyuki Hosokawa; Akihiro Hasegawa; Hiroshi Watarai; Masaru Taniguchi; Masakatsu Yamashita; Toshinori Nakayama
Lymphoid enhancer factor interacts with GATA-3 and controls its function in T helper type 2 cells.
Immunology 2008;125(3):377-86.
2008: Ryo Shinnakasu; Masakatsu Yamashita; Makoto Kuwahara; Hiroyuki Hosokawa; Akihiro Hasegawa; Shinichiro Motohashi; Toshinori Nakayama
Gfi1-mediated stabilization of GATA3 protein is required for Th2 cell differentiation.
The Journal of biological chemistry 2008;283(42):28216-25.
2008: Kiyoshi Hirahara; Masakatsu Yamashita; Chiaki Iwamura; Kenta Shinoda; Akihiro Hasegawa; Hirohisa Yoshizawa; Haruhiko Koseki; Fumitake Gejyo; Toshinori Nakayama
Repressor of GATA regulates TH2-driven allergic airway inflammation and airway hyperresponsiveness.
The Journal of allergy and clinical immunology 2008;122(3):512-20.e11.
2008: Toshihiro Ito; Akihiro Hasegawa; Hiroyuki Hosokawa; Masakatsu Yamashita; Shinichiro Motohashi; Takashi Naka; Yuko Okamoto; Yukiko Fujita; Yasuyuki Ishii; Masaru Taniguchi; Ikuya Yano; Toshinori Nakayama
Human Th1 differentiation induced by lipoarabinomannan/lipomannan from Mycobacterium bovis BCG Tokyo-172.
International immunology 2008;20(7):849-60.
2008: Toshinori Nakayama; Masakatsu Yamashita
Initiation and maintenance of Th2 cell identity.
Current opinion in immunology 2008;20(3):265-71.
2008: Masakatsu Yamashita; Makoto Kuwahara; Akane Suzuki; Kiyoshi Hirahara; Ryo Shinnaksu; Hiroyuki Hosokawa; Akihiro Hasegawa; Shinichiro Motohashi; Atsushi Iwama; Toshinori Nakayama
Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene.
The Journal of experimental medicine 2008;205(5):1109-20.
2008: Masakatsu Yamashita; Toshinori Nakayama
Progress in allergy signal research on mast cells: regulation of allergic airway inflammation through toll-like receptor 4-mediated modification of mast cell function.
Journal of pharmacological sciences 2008;106(3):332-5.
2007: Chiaki Iwamura; Motoko Y Kimura; Kenta Shinoda; Yusuke Endo; Akihiro Hasegawa; Masakatsu Yamashita; Toshinori Nakayama
Schnurri-2 regulates Th2-dependent airway inflammation and airway hyperresponsiveness.
International immunology 2007;19(6):755-62.
2007: Motoko Y Kimura; Chiaki Iwamura; Akane Suzuki; Takako Miki; Akihiro Hasegawa; Kaoru Sugaya; Masakatsu Yamashita; Shunsuke Ishii; Toshinori Nakayama
Schnurri-2 controls memory Th1 and Th2 cell numbers in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(8):4926-36.
2007: Takaaki Kaneko; Hiroyuki Hosokawa; Masakatsu Yamashita; Chrong-Reen Wang; Akihiro Hasegawa; Motoko Y Kimura; Masayuki Kitajiama; Fumio Kimura; Masaru Miyazaki; Toshinori Nakayama
Chromatin remodeling at the Th2 cytokine gene loci in human type 2 helper T cells.
Molecular immunology 2007;44(9):2249-56.
2007: Masakatsu Yamashita; Atsushi Onodera; Toshinori Nakayama
Immune mechanisms of allergic airway disease: regulation by transcription factors.
Critical reviews in immunology 2007;27(6):539-46.
2006: Hiroyuki Hosokawa; Motoko Y Kimura; Ryo Shinnakasu; Akane Suzuki; Takako Miki; Haruhiko Koseki; Maarten van Lohuizen; Masakatsu Yamashita; Toshinori Nakayama
Regulation of Th2 cell development by Polycomb group gene bmi-1 through the stabilization of GATA3.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(11):7656-64.
2006: Ryo Shinnakasu; Masakatsu Yamashita; Kenta Shinoda; Yusuke Endo; Hiroyuki Hosokawa; Akihiro Hasegawa; Shinji Ikemizu; Toshinori Nakayama
Critical YxKxHxxxRP motif in the C-terminal region of GATA3 for its DNA binding and function.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(9):5801-10.
2006: Yoshiyuki Tenda; Masakatsu Yamashita; Motoko Y Kimura; Akihiro Hasegawa; Chiori Shimizu; Masayuki Kitajima; Atsushi Onodera; Akane Suzuki; Nobuo Seki; Toshinori Nakayama
Hyperresponsive TH2 cells with enhanced nuclear factor-kappa B activation induce atopic dermatitis-like skin lesions in Nishiki-nezumi Cinnamon/Nagoya mice.
The Journal of allergy and clinical immunology 2006;118(3):725-33.
2006: Masakatsu Yamashita; Kiyoshi Hirahara; Ryo Shinnakasu; Hiroyuki Hosokawa; Satoko Norikane; Motoko Y Kimura; Akihiro Hasegawa; Toshinori Nakayama
Crucial role of MLL for the maintenance of memory T helper type 2 cell responses.
Immunity 2006;24(5):611-22.
2006: Akihiro Hasegawa; Takako Miki; Hiroyuki Hosokawa; Mohammad B Hossain; Chiori Shimizu; Kahoko Hashimoto; Motoko Y Kimura; Masakatsu Yamashita; Toshinori Nakayama
Impaired GATA3-dependent chromatin remodeling and Th2 cell differentiation leading to attenuated allergic airway inflammation in aging mice.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(4):2546-54.
2006: Yukiko Nigo; Masakatsu Yamashita; Kiyoshi Hirahara; Ryo Shinnakasu; Masamichi Inami; Motoko Kimura; Akihiro Hasegawa; Yoichi Kohno; Toshinori Nakayama
Regulation of allergic airway inflammation through Toll-like receptor 4-mediated modification of mast cell function.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(7):2286-91.
2005: Masakatsu Yamashita; Ryo Shinnakasu; Hikari Asou; Motoko Kimura; Akihiro Hasegawa; Kahoko Hashimoto; Naoya Hatano; Masato Ogata; Toshinori Nakayama
Ras-ERK MAPK cascade regulates GATA3 stability and Th2 differentiation through ubiquitin-proteasome pathway.
The Journal of biological chemistry 2005;280(33):29409-19.
2005: Takeshi Miyamoto; Takaaki Kaneko; Masakatsu Yamashita; Yoshiyuki Tenda; Masamichi Inami; Akane Suzuki; Sohtaro Ishii; Motoko Kimura; Kahoko Hashimoto; Hideaki Shimada; Hiroshi Yahata; Takenori Ochiai; Izumu Saito; James DeGregori; Toshinori Nakayama
Prolonged skin allograft survival by IL-10 gene-introduced CD4 T cell administration.
International immunology 2005;17(6):759-68.
2005: Motoko Y Kimura; Hiroyuki Hosokawa; Masakatsu Yamashita; Akihiro Hasegawa; Chiaki Iwamura; Hiroshi Watarai; Masaru Taniguchi; Tsuyoshi Takagi; Shunsuke Ishii; Toshinori Nakayama
Regulation of T helper type 2 cell differentiation by murine Schnurri-2.
The Journal of experimental medicine 2005;201(3):397-408.
2004: Takuo Katsumoto; Motoko Kimura; Masakatsu Yamashita; Hiroyuki Hosokawa; Kahoko Hashimoto; Akihiro Hasegawa; Miyuki Omori; Takeshi Miyamoto; Masaru Taniguchi; Toshinori Nakayama
STAT6-dependent differentiation and production of IL-5 and IL-13 in murine NK2 cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(8):4967-75.
2004: Masakatsu Yamashita; Ryo Shinnakasu; Yukiko Nigo; Motoko Kimura; Akihiro Hasegawa; Masaru Taniguchi; Toshinori Nakayama
Interleukin (IL)-4-independent maintenance of histone modification of the IL-4 gene loci in memory Th2 cells.
The Journal of biological chemistry 2004;279(38):39454-64.
2004: Masakatsu Yamashita; Maki Ukai-Tadenuma; Takeshi Miyamoto; Kaoru Sugaya; Hiroyuki Hosokawa; Akihiro Hasegawa; Motoko Kimura; Masaru Taniguchi; James DeGregori; Toshinori Nakayama
Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci.
The Journal of biological chemistry 2004;279(26):26983-90.
2004: Masamichi Inami; Masakatsu Yamashita; Yoshiyuki Tenda; Akihiro Hasegawa; Motoko Kimura; Kahoko Hashimoto; Nobuo Seki; Masaru Taniguchi; Toshinori Nakayama
CD28 costimulation controls histone hyperacetylation of the interleukin 5 gene locus in developing th2 cells.
The Journal of biological chemistry 2004;279(22):23123-33.
2003: Miyuki Omori; Masakatsu Yamashita; Masamichi Inami; Maki Ukai-Tadenuma; Motoko Kimura; Yukiko Nigo; Hiroyuki Hosokawa; Akihiro Hasegawa; Masaru Taniguchi; Toshinori Nakayama
CD8 T cell-specific downregulation of histone hyperacetylation and gene activation of the IL-4 gene locus by ROG, repressor of GATA.
Immunity 2003;19(2):281-94.
2003: Kaoru Murata; Masamichi Inami; Akihiro Hasegawa; Shuichi Kubo; Motoko Kimura; Masakatsu Yamashita; Hiroyuki Hosokawa; Tomokazu Nagao; Kazuo Suzuki; Kahoko Hashimoto; Hiroshi Shinkai; Haruhiko Koseki; Masaru Taniguchi; Steven F Ziegler; Toshinori Nakayama
CD69-null mice protected from arthritis induced with anti-type II collagen antibodies.
International immunology 2003;15(8):987-92.
2003: Takushi Shirai; Kumiko K Magara; Shinichiro Motohashi; Masakatsu Yamashita; Motoko Kimura; Yasushi Suwazomo; Koji Nogawa; Takayuki Kuriyama; Masaru Taniguchi; Toshinori Nakayama
TH1-biased immunity induced by exposure to Antarctic winter.
The Journal of allergy and clinical immunology 2003;111(6):1353-60.
2003: Tohru Kamata; Masakatsu Yamashita; Motoko Kimura; Kaoru Murata; Masamichi Inami; Chiori Shimizu; Kaoru Sugaya; Chrong-Reen Wang; Masaru Taniguchi; Toshinori Nakayama
src homology 2 domain-containing tyrosine phosphatase SHP-1 controls the development of allergic airway inflammation.
The Journal of clinical investigation 2003;111(1):109-19.
2002: Masakatsu Yamashita; Maki Ukai-Tadenuma; Motoko Kimura; Miyuki Omori; Masamichi Inami; Masaru Taniguchi; Toshinori Nakayama
Identification of a conserved GATA3 response element upstream proximal from the interleukin-13 gene locus.
The Journal of biological chemistry 2002;277(44):42399-408.
2002: Youichi Shibata; Tohru Kamata; Motoko Kimura; Masakatsu Yamashita; Chrong-Reen Wang; Kaoru Murata; Masaru Miyazaki; Masaru Taniguchi; Naohiro Watanabe; Toshinori Nakayama
Ras activation in T cells determines the development of antigen-induced airway hyperresponsiveness and eosinophilic inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(4):2134-40.
2002: Emiko Kikkawa; Masakatsu Yamashita; Motoko Kimura; Miyuki Omori; Kaoru Sugaya; Chiori Shimizu; Takuo Katsumoto; Masahiko Ikekita; Masaru Taniguchi; Toshinori Nakayama
T(h)1/T(h)2 cell differentiation of developing CD4 single-positive thymocytes.
International immunology 2002;14(8):943-51.
2002: Toshinori Nakayama; Deborah J Kasprowicz; Masakatsu Yamashita; Lisa A Schubert; Geoffery Gillard; Motoko Kimura; Arnaud Didierlaurent; Haruhiko Koseki; Steven F Ziegler
The generation of mature, single-positive thymocytes in vivo is dysregulated by CD69 blockade or overexpression.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(1):87-94.
2001: Motoko Kimura; Y Koseki; Masakatsu Yamashita; N Watanabe; Chiori Shimizu; Takuo Katsumoto; T Kitamura; Masaru Taniguchi; Haruhiko Koseki; Toshinori Nakayama
Regulation of Th2 cell differentiation by mel-18, a mammalian polycomb group gene.
Immunity 2001;15(2):275-87.
2001: Toshinori Nakayama; Masakatsu Yamashita; Tetsu Kawano; C Shimizu; Y Shibata; T Kamata; Yoshikatsu Kaneko; Seiichiro Kobayashi; Ushio Takeda; Shinichiro Motohashi; J Cui; Masaru Taniguchi
The role of alpha-galactosylceramide-activated Valpha14 natural killer T cells in the regulation of Th2 cell differentiation.
International archives of allergy and immunology 2001;124(1-3):38-42.
2001: Chiori Shimizu; H Kawamoto; Masakatsu Yamashita; Motoko Kimura; E Kondou; Yoshikatsu Kaneko; Seiji Okada; Takeshi Tokuhisa; M Yokoyama; Masaru Taniguchi; Y Katsura; Toshinori Nakayama
Progression of T cell lineage restriction in the earliest subpopulation of murine adult thymus visualized by the expression of lck proximal promoter activity.
International immunology 2001;13(1):105-17.
2000: Masakatsu Yamashita; M Katsumata; Makio Iwashima; Motoko Kimura; Chiori Shimizu; Tohru Kamata; Tae Kwang Shin; N Seki; S Suzuki; Masaru Taniguchi; Toshinori Nakayama
T cell receptor-induced calcineurin activation regulates T helper type 2 cell development by modifying the interleukin 4 receptor signaling complex.
The Journal of experimental medicine 2000;191(11):1869-79.
2000: Motoko Kimura; Masakatsu Yamashita; M Kubo; Makio Iwashima; Chiori Shimizu; K Tokoyoda; J Chiba; Masaru Taniguchi; M Katsumata; Toshinori Nakayama
Impaired Ca/calcineurin pathway in in vivo anergized CD4 T cells.
International immunology 2000;12(6):817-24.
2000: K Ito; M Karasawa; Tetsu Kawano; T Akasaka; Haruhiko Koseki; Yasunori Akutsu; E Kondo; S Sekiya; K Sekikawa; Michishige Harada; Masakatsu Yamashita; Toshinori Nakayama; Masaru Taniguchi
Involvement of decidual Valpha14 NKT cells in abortion.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(2):740-4.
2000: Y Kaneko; Michishige Harada; T Kawano; Masakatsu Yamashita; Y Shibata; F Gejyo; Toshinori Nakayama; Masaru Taniguchi
Augmentation of Valpha14 NKT cell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitis.
The Journal of experimental medicine 2000;191(1):105-14.
1999: J Cui; N Watanabe; T Kawano; Masakatsu Yamashita; T Kamata; Chiori Shimizu; Motoko Kimura; E Shimizu; J Koike; H Koseki; Y Tanaka; Masaru Taniguchi; Toshinori Nakayama
Inhibition of T helper cell type 2 cell differentiation and immunoglobulin E response by ligand-activated Valpha14 natural killer T cells.
The Journal of experimental medicine 1999;190(6):783-92.
1999: Hiroshi Sato; Toshinori Nakayama; Yoshikazu Tanaka; Masakatsu Yamashita; Y Shibata; E Kondo; Y Saito; Masaru Taniguchi
Induction of differentiation of pre-NKT cells to mature Valpha14 NKT cells by granulocyte/macrophage colony-stimulating factor.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(13):7439-44.
1999: Masakatsu Yamashita; Motoko Kimura; M Kubo; Chiori Shimizu; T Tada; R M Perlmutter; Toshinori Nakayama
T cell antigen receptor-mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(3):1024-9.