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Fang Yan

Research Profile

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Michael J Rosen; Amar B Singh; Luc Van Kaer; M Kay Washington; Jörn-Hendrik Weitkamp; Christopher S Williams; Rupesh Chaturvedi; Lori A Coburn; Scott S Coggeshall; Lindsay A Kuhnhein; Elizabeth M McDonough; Preston D Moore; R Stokes Peebles; Fang Yan; Keith T Wilson
STAT6 deficiency ameliorates severity of oxazolone colitis by decreasing expression of claudin-2 and Th2-inducing cytokines.
Lihong Wang; Hailong Cao; Tianhui Hu; Dawn A Israel; Liping Liu; Ning Lu; Richard M Peek; D Brent Polk; Bangmao Wang; Fang Yan
Berberine inhibits proliferation and down-regulates epidermal growth factor receptor through activation of Cbl in colon tumor cells.
Yongqin Zhang; Philip E Dubé; M Kay Washington; Fang Yan; D Brent Polk
ErbB2 and ErbB3 regulate recovery from dextran sulfate sodium-induced colitis by promoting mouse colon epithelial cell survival.

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All Publications

2013: Michael J Rosen; Amar B Singh; Luc Van Kaer; M Kay Washington; Jörn-Hendrik Weitkamp; Christopher S Williams; Rupesh Chaturvedi; Lori A Coburn; Scott S Coggeshall; Lindsay A Kuhnhein; Elizabeth M McDonough; Preston D Moore; R Stokes Peebles; Fang Yan; Keith T Wilson
STAT6 deficiency ameliorates severity of oxazolone colitis by decreasing expression of claudin-2 and Th2-inducing cytokines.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(4):1849-58.
2013: Lihong Wang; Hailong Cao; Tianhui Hu; Dawn A Israel; Liping Liu; Ning Lu; Richard M Peek; D Brent Polk; Bangmao Wang; Fang Yan
Berberine inhibits proliferation and down-regulates epidermal growth factor receptor through activation of Cbl in colon tumor cells.
PloS one 2013;8(2):e56666.
2012: Yongqin Zhang; Philip E Dubé; M Kay Washington; Fang Yan; D Brent Polk
ErbB2 and ErbB3 regulate recovery from dextran sulfate sodium-induced colitis by promoting mouse colon epithelial cell survival.
Laboratory investigation; a journal of technical methods and pathology 2012;92(3):437-50.
2012: Lihong Wang; Keith T Wilson; M Wade Calcutt; Hanwei Cao; Rupesh Chaturvedi; Tianhui Hu; Liping Liu; D Brent Polk; Xiubao Ren; Yan Shi; Fang Yan
Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor.
PloS one 2012;7(5):e36418.
2011: Rupesh Chaturvedi; Pelayo Correa; Thibaut de Sablet; Alberto G Delgado; Alain P Gobert; Svea Hoge; Dawn A Israel; Richard M Peek; M Blanca Piazuelo; D Brent Polk; Judith Romero-Gallo; Mohammad Asim; Daniel P Barry; Robert A Casero; Lydia E Wroblewski; Fang Yan; Keith T Wilson
Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA.
Gastroenterology 2011;141(5):1696-708.e1-2.
2011: Stuart S Hobbs; Dongchun Liang; Matthew T Mullane; Karen L Edelblum; Mark R Frey; Jeremy A Goettel; Fang Yan; D Brent Polk
TNF transactivation of EGFR stimulates cytoprotective COX-2 expression in gastrointestinal epithelial cells.
American journal of physiology. Gastrointestinal and liver physiology 2011;301(2):G220-9.
2010: Fang Yan; D Brent Polk
Disruption of NF-kappaB signalling by ancient microbial molecules: novel therapies of the future?
Gut 2010;59(4):421-6.
2010: Fang Yan; David Brent Polk
Probiotics: progress toward novel therapies for intestinal diseases.
Current opinion in gastroenterology 2010;26(2):95-101.
2009: Fang Yan; Hanwei Cao; Rupesh Chaturvedi; Uma Krishna; Stuart S Hobbs; Peter J Dempsey; Richard M Peek; Timothy L Cover; M Kay Washington; Keith T Wilson; D Brent Polk
Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis.
Gastroenterology 2009;136(4):1297-1307, e1-3.
2009: Toni A Nagy; Mark R Frey; Fang Yan; Dawn A Israel; D Brent Polk; Richard M Peek
Helicobacter pylori regulates cellular migration and apoptosis by activation of phosphatidylinositol 3-kinase signaling.
The Journal of infectious diseases 2009;199(5):641-51.
2008: Charles Vanderpool; Fang Yan; D Brent Polk
Mechanisms of probiotic action: Implications for therapeutic applications in inflammatory bowel diseases.
Inflammatory bowel diseases 2008;14(11):1585-96.
2008: Karen L Edelblum; Jeremy Goettel; Tatsuki Koyama; Steven J McElroy; Fang Yan; D Brent Polk
TNFR1 promotes tumor necrosis factor-mediated mouse colon epithelial cell survival through RAF activation of NF-kappaB.
The Journal of biological chemistry 2008;283(43):29485-94.
2008: Toshimitsu Yamaoka; Fang Yan; Hanwei Cao; Stuart S Hobbs; Rebecca S Dise; Wei Tong; D Brent Polk
Transactivation of EGF receptor and ErbB2 protects intestinal epithelial cells from TNF-induced apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(33):11772-7.
2007: Fang Yan; Hanwei Cao; Timothy L Cover; Robert Whitehead; M Kay Washington; D Brent Polk
Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth.
Gastroenterology 2007;132(2):562-75.
2006: Fang Yan; D Brent Polk
Probiotics as functional food in the treatment of diarrhea.
Current opinion in clinical nutrition and metabolic care 2006;9(6):717-21.
2006: Karen L Edelblum; Fang Yan; Toshimitsu Yamaoka; D Brent Polk
Regulation of apoptosis during homeostasis and disease in the intestinal epithelium.
Inflammatory bowel diseases 2006;12(5):413-24.
2004: Fang Yan; D Brent Polk
Commensal bacteria in the gut: learning who our friends are.
Current opinion in gastroenterology 2004;20(6):565-71.
2004: Fang Yan; Sutha K John; Guinn Wilson; David S Jones; M Kay Washington; D Brent Polk
Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation.
The Journal of clinical investigation 2004;114(9):1272-80.
2003: Julissa Corredor; Fang Yan; Christopher C Shen; Wei Tong; Sutha K John; Guinn Wilson; Robert Whitehead; D Brent Polk
Tumor necrosis factor regulates intestinal epithelial cell migration by receptor-dependent mechanisms.
American journal of physiology. Cell physiology 2003;284(4):C953-61.
2002: Fang Yan; D Brent Polk
Probiotic bacterium prevents cytokine-induced apoptosis in intestinal epithelial cells.
The Journal of biological chemistry 2002;277(52):50959-65.
2001: Fang Yan; Sutha K John; D Brent Polk
Kinase suppressor of Ras determines survival of intestinal epithelial cells exposed to tumor necrosis factor.
Cancer research 2001;61(24):8668-75.
2001: Rajnish A Gupta; D Brent Polk; Uma Krishna; Dawn A Israel; Fang Yan; Raymond DuBois; Richard M Peek
Activation of peroxisome proliferator-activated receptor gamma suppresses nuclear factor kappa B-mediated apoptosis induced by Helicobacter pylori in gastric epithelial cells.
The Journal of biological chemistry 2001;276(33):31059-66.
2001: Fang Yan; D Brent Polk
Kinase suppressor of ras is necessary for tumor necrosis factor alpha activation of extracellular signal-regulated kinase/mitogen-activated protein kinase in intestinal epithelial cells.
Cancer research 2001;61(3):963-9.
1999: Fang Yan; D Brent Polk
Aminosalicylic acid inhibits IkappaB kinase alpha phosphorylation of IkappaBalpha in mouse intestinal epithelial cells.
The Journal of biological chemistry 1999;274(51):36631-6.
1999: GC Kaiser; Fang Yan; D Brent Polk
Conversion of TNF alpha from antiproliferative to proliferative ligand in mouse intestinal epithelial cells by regulating mitogen-activated protein kinase.
Experimental cell research 1999;249(2):349-58.
1999: GC Kaiser; Fang Yan; D Brent Polk
Mesalamine blocks tumor necrosis factor growth inhibition and nuclear factor kappaB activation in mouse colonocytes.
Gastroenterology 1999;116(3):602-9.