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George Yancopoulos

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Heather M McGee; Andrew J Murphy; Barbara A Schmidt; Sean Stevens; David M Valenzuela; George D Yancopoulos; Carmen J Booth; Richard A Flavell; Valerie Horsley
IL-22 Promotes Fibroblast-Mediated Wound Repair in the Skin.
Alexandra Eichten; Jennifer Griffith; Hsin Chieh Lin; Alexander P Adler; Blerta Cooper; Yi Wei; George D Yancopoulos; Gavin Thurston
Rapid decrease in tumor perfusion following VEGF blockade predicts long-term tumor growth inhibition in preclinical tumor models.
Christopher Daly; Alexandra Eichten; Alastair H Kyle; Alshad S Lalani; Andrew I Minchinton; Nicholas Papadopoulos; Elizabeth Pasnikowski; Alexander Adler; Carla Castanaro; George D Yancopoulos; Gavin Thurston
Angiopoietin-2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition.

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2013: Heather M McGee; Andrew J Murphy; Barbara A Schmidt; Sean Stevens; David M Valenzuela; George D Yancopoulos; Carmen J Booth; Richard A Flavell; Valerie Horsley
IL-22 Promotes Fibroblast-Mediated Wound Repair in the Skin.
The Journal of investigative dermatology 2013;133(5):1321-9.
2013: Alexandra Eichten; Jennifer Griffith; Hsin Chieh Lin; Alexander P Adler; Blerta Cooper; Yi Wei; George D Yancopoulos; Gavin Thurston
Rapid decrease in tumor perfusion following VEGF blockade predicts long-term tumor growth inhibition in preclinical tumor models.
Angiogenesis 2013;16(2):429-41.
2013: Christopher Daly; Alexandra Eichten; Alastair H Kyle; Alshad S Lalani; Andrew I Minchinton; Nicholas Papadopoulos; Elizabeth Pasnikowski; Alexander Adler; Carla Castanaro; George D Yancopoulos; Gavin Thurston
Angiopoietin-2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition.
Cancer research 2013;73(1):108-18.
2012: Jeffrey S Heier; Allen Ho; Peter K Kaiser; Bernd Kirchhof; Jean-Francois Korobelnik; Quan Dong Nguyen; Yuichiro Ogura; Rupert Sandbrink; Ursula Schmidt-Erfurth; Christian Simader; Bernd Sommerauer; Yuhwen Soo; Neil Stahl; Robert Vitti; George D Yancopoulos; Majid Anderesi; Alyson J Berliner; David M Brown; Victor Chong; Georg Groetzbach
Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration.
Ophthalmology 2012;119(12):2537-48.
2012: Samuel Huber; Andrew J Murphy; William O'Connor; Wenjun Ouyang; David M Valenzuela; George D Yancopoulos; Lauren A Zenewicz; Wei Zhang; Clara Abraham; Carmen J Booth; Lidia Bosurgi; Judy H Cho; Nicola Gagliani; Matija Hedl; Bo Hu; Francis J Huber; Richard A Flavell
IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine.
Nature 2012;491(7423):259-63.
2012: H Ralph Schumacher; Jian Wang; Steven P Weinstein; George D Yancopoulos; James Clower; Robert R Evans; William Jennings; Kenneth G Saag; Robert Terkeltaub
Rilonacept (interleukin-1 trap) for prevention of gout flares during initiation of uric acid-lowering therapy: results from a phase III randomized, double-blind, placebo-controlled, confirmatory efficacy study.
Arthritis care & research 2012;64(10):1462-70.
2012: Nicholas Papadopoulos; Erica A Pyles; Ashique Rafique; Michael P Rosconi; Qin Ruan; Ergang Shi; Neil Stahl; Joel Martin; George D Yancopoulos; Stanley J Wiegand
Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab.
Angiogenesis 2012;15(2):171-85.
2012: Fabienne Billiard; Jacquelynn Burton; Amanda DaNave; Guillaume Darrasse-Jèze; Juliana Idoyaga; Julie Kalter; Apostolos Klinakis; Christos A Kyratsous; Marylène Leboeuf; Xia Liu; Camille Lobry; Miriam Merad; Hugo Mouquet; Andrew J Murphy; Ralph M Steinman; Michelle Tait; Gavin Thurston; Janelle Waite; George D Yancopoulos; Wen Zhang; Ioannis Aifantis; Dimitris Skokos
Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice.
The Journal of experimental medicine 2012;209(5):1011-28.
2012: Evan A Stein; Cheryle Webb; Richard Wu; George D Yancopoulos; Yunling Du; Evelyn Gasparino; Maria Gutierrez; Therese Kranz; Eleanor Lisbon; Douglas Logan; Scott Mellis; William B Smith; Neil Stahl; Gary D Swergold
Effect of a monoclonal antibody to PCSK9 on LDL cholesterol.
The New England journal of medicine 2012;366(12):1108-18.
2012: H Ralph Schumacher; Yuhwen Soo; Neil Stahl; John S Sundy; Robert Terkeltaub; Steven P Weinstein; George D Yancopoulos; Shirletta King-Davis; Howard R Knapp; Scott J Mellis; Allen R Radin
Rilonacept (interleukin-1 trap) in the prevention of acute gout flares during initiation of urate-lowering therapy: results of a phase II randomized, double-blind, placebo-controlled trial.
Arthritis and rheumatism 2012;64(3):876-84.
2012: Eleanor Z Kincaid; Andrew J Murphy; Eduardo Reyes-Vargas; Jenny W Che; Julio C Delgado; Hernando Escobar; Margaret L Karow; David M Valenzuela; Raymond M Welsh; George D Yancopoulos; Ian York; Kenneth L Rock
Mice completely lacking immunoproteasomes show major changes in antigen presentation.
Nature immunology 2012;13(2):129-35.
2011: Elisa Gomez Perdiguero; Josette Philippe; Jérémie Teillon; Gavin Thurston; David M Valenzuela; George D Yancopoulos; Mélanie Durand; Ariane Galaup; Andrew J Murphy; Stéphane Germain
Alteration of developmental and pathological retinal angiogenesis in angptl4-deficient mice.
The Journal of biological chemistry 2011;286(42):36841-51.
2011: Chozhavendan Rathinam; Jose Rojas; Anthony Rongvaux; David M Valenzuela; George D Yancopoulos; Elizabeth Eynon; Markus G Manz; Andrew J Murphy; William T Poueymirou; Richard A Flavell
Efficient differentiation and function of human macrophages in humanized CSF-1 mice.
Blood 2011;118(11):3119-28.
2011: Fabienne Billiard; Guoying Chen; Sandra Coetzee; Amanda Danave; Donna Hylton; Jessica R Kirshner; Andrew J Murphy; Kara Olson; Sean Taheri; Michelle Tait; Gavin Thurston; Janelle C Waite; George D Yancopoulos; Wen Zhang; Dimitris Skokos
Ongoing Dll4-Notch signaling is required for T-cell homeostasis in the adult thymus.
European journal of immunology 2011;41(8):2207-16.
2011: Ivan B Lobov; Nicholas Papadopoulos; Yi Wei; Jingtai Cao; Eunice Cheung; Aris Economides; Gabor Halasz; Hsin C Lin; Rajeev Wudali; George D Yancopoulos; Stanley J Wiegand
The Dll4/Notch pathway controls postangiogenic blood vessel remodeling and regression by modulating vasoconstriction and blood flow.
Blood 2011;117(24):6728-37.
2011: Keith D Anderson; Li Pan; Xiao-man Yang; Virginia C Hughes; Johnathon R Walls; Melissa G Dominguez; Mary V Simmons; Patricia Burfeind; Yingzi Xue; Yi Wei; Lynn E Macdonald; Gavin Thurston; Christopher Daly; Hsin Chieh Lin; Aris N Economides; David M Valenzuela; Andrew J Murphy; George D Yancopoulos; Nicholas W Gale
Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(7):2807-12.
2011: Anthony Rongvaux; Tim Willinger; Hitoshi Takizawa; Chozhavendan Rathinam; Wojtek Auerbach; Andrew J Murphy; David M Valenzuela; George D Yancopoulos; Elizabeth Eynon; Sean Stevens; Markus G Manz; Richard A Flavell
Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(6):2378-83.
2011: Tim Willinger; Anthony Rongvaux; Hitoshi Takizawa; George D Yancopoulos; David M Valenzuela; Andrew J Murphy; Wojtek Auerbach; Elizabeth Eynon; Sean Stevens; Markus G Manz; Richard A Flavell
Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(6):2390-5.
2011: Meital Gabay; Andrew J Murphy; Mary E Pinter; David M Valenzuela; Forrest A Wright; George D Yancopoulos; PuiYee Chan; Gregory G Tall
Ric-8 proteins are molecular chaperones that direct nascent G protein α subunit membrane association.
Science signaling 2011;4(200):ra79.
2011: Yasu-Taka Azuma; Yukiko Matsuo; Hidemitsu Nakajima; George D Yancopoulos; David M Valenzuela; Andrew J Murphy; Margaret Karow; Tadayoshi Takeuchi
Interleukin-19 is a negative regulator of innate immunity and critical for colonic protection.
Journal of pharmacological sciences 2011;115(2):105-11.
2010: Cosmas Giallourakis; Andrew Franklin; Chunguang Guo; Hwei-Ling Cheng; Hye Suk Yoon; Michael Gallagher; Thomas Perlot; Milena Andzelm; Andrew J Murphy; Lynn E Macdonald; George D Yancopoulos; Frederick W Alt
Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(51):22207-12.
2010: Jingtai Cao; Lian Zhao; Yiwen Li; Yang Liu; Weihong Xiao; Ying Song; Lingyu Luo; Deqiang Huang; George D Yancopoulos; Stanley J Wiegand; Rong Wen
A subretinal matrigel rat choroidal neovascularization (CNV) model and inhibition of CNV and associated inflammation and fibrosis by VEGF trap.
Investigative ophthalmology & visual science 2010;51(11):6009-17.
2010: George D Yancopoulos
Clinical application of therapies targeting VEGF.
Cell 2010;143(1):13-6.
2010: Olivier Demaria; Philippe Pagni; Stephanie Traub; aude de gassart; Nora Branzk; Andrew J Murphy; David M Valenzuela; George D Yancopoulos; Richard A Flavell; Lena Alexopoulou
TLR8 deficiency leads to autoimmunity in mice.
The Journal of clinical investigation 2010;120(10):3651-62.
2010: Hongyan Zhu; Melissa K Mingler; Melissa L McBride; Andrew J Murphy; David M Valenzuela; George D Yancopoulos; Michael T Williams; Charles V Vorhees; Marc E Rothenberg
Abnormal response to stress and impaired NPS-induced hyperlocomotion, anxiolytic effect and corticosterone increase in mice lacking NPSR1.
Psychoneuroendocrinology 2010;35(8):1119-32.
2010: Hal M Hoffman; Peter Scott; James L Mueller; Amir Misaghi; Sean Stevens; George D Yancopoulos; Andrew Murphy; David M Valenzuela; Ru Liu-Bryan
Role of the leucine-rich repeat domain of cryopyrin/NALP3 in monosodium urate crystal-induced inflammation in mice.
Arthritis and rheumatism 2010;62(7):2170-9.
2010: Yasu-Taka Azuma; Yukiko Matsuo; Mitsuru Kuwamura; George D Yancopoulos; David M Valenzuela; Andrew J Murphy; Hidemitsu Nakajima; Margaret Karow; Tadayoshi Takeuchi
Interleukin-19 protects mice from innate-mediated colonic inflammation.
Inflammatory bowel diseases 2010;16(6):1017-28.
2010: Sergey V Shmelkov; Adília Hormigo; Deqiang Jing; Catia C Proenca; Kevin G Bath; Till Milde; Evgeny Shmelkov; Jared S Kushner; Muhamed Baljevic; Iva Dincheva; Andrew J Murphy; David M Valenzuela; Nicholas W Gale; George D Yancopoulos; Ipe Ninan; Francis S Lee; Shahin Rafii
Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice.
Nature medicine 2010;16(5):598-602, 1p following 602.
2010: David Frendewey; Rostislav Chernomorsky; Lakeisha Esau; Jinsop Om; Yingzi Xue; Andrew J Murphy; George D Yancopoulos; David M Valenzuela
The loss-of-allele assay for ES cell screening and mouse genotyping.
Methods in enzymology 2010;476():295-307.
2010: Thomas M DeChiara; William T Poueymirou; Wojtek Auerbach; David Frendewey; George D Yancopoulos; David M Valenzuela
Producing fully ES cell-derived mice from eight-cell stage embryo injections.
Methods in enzymology 2010;476():285-94.
2009: Zhe Li; Hui Huang; Patricia Boland; Melissa G Dominguez; Patricia Burfeind; Ka-Man Lai; Hsin-Chieh Lin; Nicholas W Gale; Christopher Daly; Wojtek Auerbach; David Valenzuela; George D Yancopoulos; Gavin Thurston
Embryonic stem cell tumor model reveals role of vascular endothelial receptor tyrosine phosphatase in regulating Tie2 pathway in tumor angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(52):22399-404.
2009: R Torres; L Macdonald; Susan D Croll; J Reinhardt; A Dore; S Stevens; D M Hylton; J S Rudge; R Liu-Bryan; R A Terkeltaub; George D Yancopoulos; Andrew J Murphy
Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis.
Annals of the rheumatic diseases 2009;68(10):1602-8.
2009: Sulochana S Bhandarkar; Marisa Jaconi; Levi E Fried; Michael Y Bonner; Benjamin Lefkove; Baskaran Govindarajan; Betsy N Perry; Ravi Parhar; Jamie MacKelfresh; Allie Sohn; Michael Stouffs; Ulla G Knaus; George D Yancopoulos; Yvonne Reiss; Andrew V Benest; Hellmut G Augustin; Jack L Arbiser
Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice.
The Journal of clinical investigation 2009;119(8):2359-65.
2009: Andrea T Hooper; Sergey V Shmelkov; Sunny Gupta; Till Milde; Kathryn Bambino; Kelly Gillen; Mollie Goetz; Sai Chavala; Muhamed Baljevic; Andrew J Murphy; David M Valenzuela; Nicholas W Gale; Gavin Thurston; George D Yancopoulos; Linda Vahdat; Todd Evans; Shahin Rafii
Angiomodulin is a specific marker of vasculature and regulates vascular endothelial growth factor-A-dependent neoangiogenesis.
Circulation research 2009;105(2):201-8.
2009: Meera G Nair; Yurong Du; Jacqueline G Perrigoue; Colby Zaph; Justin J Taylor; Michael H Goldschmidt; Gary P Swain; George D Yancopoulos; David M Valenzuela; Andrew Murphy; Margaret Karow; Sean Stevens; Edward J Pearce; David Artis
Alternatively activated macrophage-derived RELM-{alpha} is a negative regulator of type 2 inflammation in the lung.
The Journal of experimental medicine 2009;206(4):937-52.
2009: Laura A Crawford; Michelle A Guney; Young Ah Oh; R Andrea Deyoung; David M Valenzuela; Andrew J Murphy; George D Yancopoulos; Karen M Lyons; David R Brigstock; Aris Economides; Maureen Gannon
Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis.
Molecular endocrinology (Baltimore, Md.) 2009;23(3):324-36.
2009: Thomas M DeChiara; William T Poueymirou; Wojtek Auerbach; David Frendewey; George D Yancopoulos; David M Valenzuela
VelociMouse: fully ES cell-derived F0-generation mice obtained from the injection of ES cells into eight-cell-stage embryos.
Methods in molecular biology (Clifton, N.J.) 2009;530():311-24.
2009: Moritz Leppkes; Christoph Becker; Ivaylo I Ivanov; Sebastian Hirth; Stefan Wirtz; Clemens Neufert; Sandrine Pouly; Andrew J Murphy; David M Valenzuela; George D Yancopoulos; Burkhard Becher; Dan R Littman; Markus F Neurath
RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F.
Gastroenterology 2009;136(1):257-67.
2008: Meera G Nair; Katherine J Guild; Yurong Du; Colby Zaph; George D Yancopoulos; David M Valenzuela; Andrew Murphy; Sean Stevens; Margaret Karow; David Artis
Goblet cell-derived resistin-like molecule beta augments CD4+ T cell production of IFN-gamma and infection-induced intestinal inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(7):4709-15.
2008: Hal M Hoffman; Martin L Throne; N J Amar; Mohamed Sebai; Alan J Kivitz; Arthur Kavanaugh; Steven P Weinstein; Pavel Belomestnov; George D Yancopoulos; Neil stahl; Scott Mellis
Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies.
Arthritis and rheumatism 2008;58(8):2443-52.
2008: David A Long; Karen L Price; Ella Ioffe; Claire M Gannon; Luigi Gnudi; Kathryn E White; George D Yancopoulos; John S Rudge; Adrian S Woolf
Angiopoietin-1 therapy enhances fibrosis and inflammation following folic acid-induced acute renal injury.
Kidney international 2008;74(3):300-9.
2008: Michael Dellinger; Robert Hunter; Michael J Bernas; nicholas gale; George D Yancopoulos; Robert Erickson; Marlys H Witte
Defective remodeling and maturation of the lymphatic vasculature in Angiopoietin-2 deficient mice.
Developmental biology 2008;319(2):309-20.
2008: Sergey V Shmelkov; Jason M Butler; Andrea T Hooper; Adília Hormigo; Jared Kushner; Till Milde; Ryan St Clair; Muhamed Baljevic; Ian White; David K Jin; Amy Chadburn; Andrew J Murphy; David M Valenzuela; nicholas gale; Gavin Thurston; George D Yancopoulos; Michael D'Angelica; Nancy Kemeny; David Lyden; Shahin Rafii
CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors.
The Journal of clinical investigation 2008;118(6):2111-20.
2008: Regina Raz; Sigmar Stricker; Elizabetta Gazzerro; Julie L Clor; Florian Witte; Harikiran Nistala; Stefanie Zabski; Renata C Pereira; Lisa Stadmeyer; Xiangmin Wang; Lori Gowen; Mark W Sleeman; George D Yancopoulos; Ernesto Canalis; Stefan Mundlos; David M Valenzuela; Aris N Economides
The mutation ROR2W749X, linked to human BDB, is a recessive mutation in the mouse, causing brachydactyly, mediating patterning of joints and modeling recessive Robinow syndrome.
Development (Cambridge, England) 2008;135(9):1713-23.
2008: Chunhua Lu; Premal H Thaker; Yvonne G Lin; Whitney A Spannuth; Charles N Landen; William M Merritt; Nicholas B Jennings; Robert R Langley; David M Gershenson; George D Yancopoulos; Lee M Ellis; Robert B Jaffe; Robert L Coleman; Anil K Sood
Impact of vessel maturation on antiangiogenic therapy in ovarian cancer.
American journal of obstetrics and gynecology 2008;198(4):477.e1-9; discussion 477.e9-10.
2008: Charles F Towne; Ian A York; Joost Neijssen; Margaret L Karow; Andrew J Murphy; David M Valenzuela; George D Yancopoulos; Jacques Neefjes; Kenneth L Rock
Puromycin-sensitive aminopeptidase limits MHC class I presentation in dendritic cells but does not affect CD8 T cell responses during viral infections.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(3):1704-12.
2008: Angela Kadenhe-Chiweshe; Joey Papa; Kimberly McCrudden; Jason S Frischer; Jae-O Bae; Jianzhong Huang; Jason Fisher; Jay H Lefkowitch; Nikki Feirt; John S Rudge; Jocelyn Holash; George D Yancopoulos; Jessica J Kandel; Darrell J Yamashiro
Sustained VEGF blockade results in microenvironmental sequestration of VEGF by tumors and persistent VEGF receptor-2 activation.
Molecular cancer research : MCR 2008;6(1):1-9.
2008: Thirumalai Ramalingam; John Pesce; Faruk Sheikh; Allen W Cheever; Margaret M Mentink-Kane; Mark Wilson; Sean Stevens; David M Valenzuela; Andrew J Murphy; George D Yancopoulos; Joseph F Urban; Raymond P Donnelly; Thomas A Wynn
Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain.
Nature immunology 2008;9(1):25-33.
2008: Misa Tanaka; S Endo; T Okuda; Aris N Economides; David M Valenzuela; A J Murphy; E Robertson; Takeshi Sakurai; Atsushi Fukatsu; George D Yancopoulos; Toru Kita; Motoko Yanagita
Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury.
Kidney international 2008;73(2):181-91.
2007: David Lombard; Frederick W Alt; Hwei-Ling Cheng; Jakob Bunkenborg; Ryan S Streeper; Raul Mostoslavsky; Jennifer Kim; George D Yancopoulos; David M Valenzuela; Andrew Murphy; Yinhua Yang; Yaohui Chen; Matthew David Hirschey; Roderick T Bronson; Marcia Haigis; Leonard Guarente; Robert V Farese; Sherman Weissman; Eric Verdin; Bjoern Schwer
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.
Molecular and cellular biology 2007;27(24):8807-14.
2007: John S Rudge; Jocelyn Holash; Donna Hylton; Michelle Russell; Shelly Jiang; Raymond Leidich; Nick Papadopoulos; Erica A Pyles; Al Torri; Stanley J Wiegand; Gavin Thurston; Neil stahl; George D Yancopoulos
VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(47):18363-70.
2007: Katherine E Wortley; Karen Garcia; Haruka Okamoto; Karen Thabet; Keith D Anderson; Victor Shen; Jim P Herman; David M Valenzuela; George D Yancopoulos; Matthias H Tschöp; Andrew Murphy; Mark W Sleeman
Peptide YY regulates bone turnover in rodents.
Gastroenterology 2007;133(5):1534-43.
2007: Lauren A Zenewicz; George D Yancopoulos; David M Valenzuela; Andrew J Murphy; Margaret L Karow; Richard A Flavell
Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation.
Immunity 2007;27(4):647-59.
2007: Vesna Todorovic; David Frendewey; David E Gutstein; Yan Chen; Laina Freyer; Erin Finnegan; Fangyu Liu; Andrew Murphy; David M Valenzuela; George D Yancopoulos; Daniel B Rifkin
Long form of latent TGF-beta binding protein 1 (Ltbp1L) is essential for cardiac outflow tract septation and remodeling.
Development (Cambridge, England) 2007;134(20):3723-32.
2007: Seandel Marco; Daylon James; Sergey V Shmelkov; Ilaria Falciatori; Jiyeon Kim; Sai Chavala; Douglas Scherr; Fan Zhang; Richard Torres; nicholas gale; George D Yancopoulos; Andrew Murphy; David M Valenzuela; Robin M Hobbs; Pier Paolo Pandolfi; Shahin Rafii
Generation of functional multipotent adult stem cells from GPR125+ germline progenitors.
Nature 2007;449(7160):346-50.
2007: Richard Torres; Susan D Croll; Jeffrey Vercollone; Joel Reinhardt; Jennifer Griffiths; Stephanie Zabski; Keith D Anderson; Niels Adams; Lori Gowen; Mark W Sleeman; David M Valenzuela; Stanley J Wiegand; George D Yancopoulos; Andrew J Murphy
Mice genetically deficient in neuromedin U receptor 2, but not neuromedin U receptor 1, have impaired nociceptive responses.
Pain 2007;130(3):267-78.
2007: Hendrik Verheul; Hans-Joerg Hammers; Karen van Erp; Yonfeng Wei; Tolib B Sanni; Brenda Salumbides; Zheng (David) Qian; George D Yancopoulos; Roberto Pili
Vascular endothelial growth factor trap blocks tumor growth, metastasis formation, and vascular leakage in an orthotopic murine renal cell cancer model.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(14):4201-8.
2007: Gavin Thurston; Irene Noguera-Troise; George D Yancopoulos
The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth.
Nature reviews. Cancer 2007;7(5):327-31.
2007: Haruka Okamoto; Esther Latres; Rong Liu; Karen Thabet; Andrew Murphy; David Valenzeula; George D Yancopoulos; Trevor N Stitt; David J Glass; Mark W Sleeman
Genetic deletion of Trb3, the mammalian Drosophila tribbles homolog, displays normal hepatic insulin signaling and glucose homeostasis.
Diabetes 2007;56(5):1350-6.
2007: Hiroshi Shimoda; Michael J Bernas; Marlys H Witte; nicholas gale; George D Yancopoulos; Seiji Kato
Abnormal recruitment of periendothelial cells to lymphatic capillaries in digestive organs of angiopoietin-2-deficient mice.
Cell and tissue research 2007;328(2):329-37.
2007: To-Ha Thai; Dinis Calado; Stefano Casola; K Mark Ansel; Changchun Xiao; Yingzi Xue; Andrew Murphy; David Frendewey; David M Valenzuela; Jeffery L Kutok; Marc Schmidt-Supprian; Nikolaus Rajewsky; George D Yancopoulos; Anjana Rao; Klaus Rajewsky
Regulation of the germinal center response by microRNA-155.
Science (New York, N.Y.) 2007;316(5824):604-8.
2007: Phyllis R Wachsberger; Randy Burd; Chris Cardi; Mathew Thakur; Constantine Daskalakis; Jocelyn Holash; George D Yancopoulos; Adam Dicker
VEGF trap in combination with radiotherapy improves tumor control in u87 glioblastoma.
International journal of radiation oncology, biology, physics 2007;67(5):1526-37.
2007: Melissa G Dominguez; Virginia C Hughes; Li Pan; Mary Simmons; Christopher Daly; Keith Anderson; Irene Noguera-Troise; Andrew J Murphy; David M Valenzuela; Samuel Davis; Gavin Thurston; George D Yancopoulos; nicholas gale
Vascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3243-8.
2007: Ivan Lobov; R A Renard; Nick Papadopoulos; nicholas gale; Gavin Thurston; George D Yancopoulos; Stanley J Wiegand
Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3219-24.
2007: Irene Noguera-Troise; Christopher Daly; Nicholas J Papadopoulos; Sandra Coetzee; Pat Boland; nicholas gale; Hsin Chieh Lin; George D Yancopoulos; Gavin Thurston
Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis.
Novartis Foundation symposium 2007;283():106-20; discussion 121-5, 238-41.
2007: Lora J Kasselman; Jennifer Kintner; Alexandra Sideris; Elizabeth Pasnikowski; Jason W Krellman; Sagar Shah; John S Rudge; George D Yancopoulos; Stanley J Wiegand; Susan D Croll
Dexamethasone treatment and ICAM-1 deficiency impair VEGF-induced angiogenesis in adult brain.
Journal of vascular research 2007;44(4):283-91.
2007: William T Poueymirou; Wojtek Auerbach; David Frendewey; Joseph F Hickey; Jennifer M Escaravage; Lakeisha Esau; Anthony T Doré; Sean Stevens; Niels Adams; Melissa G Dominguez; nicholas gale; George D Yancopoulos; Thomas M DeChiara; David M Valenzuela
F0 generation mice fully derived from gene-targeted embryonic stem cells allowing immediate phenotypic analyses.
Nature biotechnology 2007;25(1):91-9.
2007: nicholas gale; Remko Prevo; Jorge Espinosa; David J P Ferguson; Melissa G Dominguez; George D Yancopoulos; Gavin Thurston; David G Jackson
Normal lymphatic development and function in mice deficient for the lymphatic hyaluronan receptor LYVE-1.
Molecular and cellular biology 2007;27(2):595-604.
2006: Irene Noguera-Troise; Christopher Daly; Nicholas J Papadopoulos; Sandra Coetzee; Pat Boland; nicholas gale; Hsin Chieh Lin; George D Yancopoulos; Gavin Thurston
Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis.
Nature 2006;444(7122):1032-7.
2006: Christopher Daly; Elizabeth Pasnikowski; Elena Burova; Vivian Wong; Thomas H Aldrich; Jennifer Griffiths; Ella Ioffe; Thomas J Daly; James P Fandl; Nick Papadopoulos; Donald M McDonald; Gavin Thurston; George D Yancopoulos; John S Rudge
Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(42):15491-6.
2006: Betsy N Perry; Baskaran Govindarajan; Sulochana S Bhandarkar; Ulla G Knaus; Monika Valo; Celina Sturk; Carol O Carrillo; Allie Sohn; Francesca Cerimele; Daniel J Dumont; Albert Losken; Joseph Williams; Lawrence F Brown; Xiaolian Tan; Ella Ioffe; George D Yancopoulos; Jack L Arbiser
Pharmacologic blockade of angiopoietin-2 is efficacious against model hemangiomas in mice.
The Journal of investigative dermatology 2006;126(10):2316-22.
2006: Marcia Haigis; Raul Mostoslavsky; Kevin Haigis; Kamau Fahie; Danos C Christodoulou; Andrew J Murphy; David M Valenzuela; George D Yancopoulos; Margaret L Karow; Gil Blander; Cynthia Wolberger; Tomas A Prolla; Richard Weindruch; Frederick W Alt; Leonard Guarente
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.
Cell 2006;126(5):941-54.
2006: Christoph Becker; Heike Dornhoff; Clemens Neufert; Massimo C Fantini; Stefan Wirtz; Sabine Huebner; Alexei Nikolaev; Hans-Anton Lehr; Andrew J Murphy; David M Valenzuela; George D Yancopoulos; Peter R Galle; Margaret L Karow; Markus F Neurath
Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(5):2760-4.
2006: Simon P Hogan; Luqman Seidu; Carine Blanchard; Katherine Groschwitz; Anil Mishra; Margaret L Karow; Richard Ahrens; David Artis; Andrew J Murphy; David M Valenzuela; George D Yancopoulos; Marc E Rothenberg
Resistin-like molecule beta regulates innate colonic function: barrier integrity and inflammation susceptibility.
The Journal of allergy and clinical immunology 2006;118(1):257-68.
2006: Betty Y Y Tam; Kevin Wei; John S Rudge; Jana Hoffman; Jocelyn Holash; Sang-ki Park; Jenny Yuan; Colleen Hefner; Cecile Chartier; Jeng-Shin Lee; Shelly Jiang; Nihar R Nayak; Nihar R Niyak; Frans A Kuypers; Lisa Ma; Uma Sundram; Grace Wu; Joseph A Garcia; Stanley L Schrier; Jacquelyn J Maher; Randall S Johnson; George D Yancopoulos; Richard C Mulligan; Calvin J Kuo
VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis.
Nature medicine 2006;12(7):793-800.
2006: Jocelyn Holash; Gavin Thurston; John S Rudge; George D Yancopoulos; Alex A. Adjei; Gabriele Bergers; Bronislaw Pytowski; Mark D Pegram; Michael S Gordon
Inhibitors of growth factor receptors, signaling pathways and angiogenesis as therapeutic molecular agents.
Cancer metastasis reviews 2006;25(2):243-52.
2006: Raul Mostoslavsky; Katrin F Chua; David Lombard; Wendy W Pang; Miriam R Fischer; Lionel Gellon; Pingfang Liu; Gustavo Mostoslavsky; Sonia Franco; Michael M Murphy; Kevin D Mills; Parin Patel; Joyce T Hsu; Andrew L Hong; Ethan Ford; Hwei-Ling Cheng; Caitlin Kennedy; Nomeli P Nunez; Roderick Bronson; David Frendewey; Wojtek Auerbach; David Valenzuela; Margaret Karow; Michael Hottiger; Stephen Hursting; J Carl Barrett; Leonard Guarente; Richard Mulligan; Bruce Demple; George D Yancopoulos; Frederick W Alt
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.
Cell 2006;124(2):315-29.
2006: Stephanie A Amici; William A Dunn; Andrew J Murphy; Niels Adams; nicholas gale; David M Valenzuela; George D Yancopoulos; Lucia Notterpek
Peripheral myelin protein 22 is in complex with alpha6beta4 integrin, and its absence alters the Schwann cell basal lamina.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(4):1179-89.
2005: Katherine E Wortley; Keith D Anderson; Jason Yasenchak; Andrew Murphy; David M Valenzuela; Sabrina Diano; George D Yancopoulos; Stanley J Wiegand; Mark W Sleeman
Agouti-related protein-deficient mice display an age-related lean phenotype.
Cell metabolism 2005;2(6):421-7.
2005: Charles F Towne; Ian A York; Joost Neijssen; Margaret L Karow; Andrew J Murphy; David M Valenzuela; George D Yancopoulos; Jacques Neefjes; Kenneth L Rock
Leucine aminopeptidase is not essential for trimming peptides in the cytosol or generating epitopes for MHC class I antigen presentation.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(10):6605-14.
2005: Limin Hu; Judith Hofmann; Jocelyn Holash; George D Yancopoulos; Anil K Sood; Robert B Jaffe
Vascular endothelial growth factor trap combined with paclitaxel strikingly inhibits tumor and ascites, prolonging survival in a human ovarian cancer model.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(19 Pt 1):6966-71.
2005: Gavin Thurston; Quan Wang; Fabienne Baffert; John S Rudge; Nicholas Papadopoulos; Danielle Jean-Guillaume; Stanley J Wiegand; George D Yancopoulos; Donald M McDonald
Angiopoietin 1 causes vessel enlargement, without angiogenic sprouting, during a critical developmental period.
Development (Cambridge, England) 2005;132(14):3317-26.
2005: Yuji Oshima; Sachiko Oshima; Hiroyuki Nambu; Shu Kachi; Kyoichi Takahashi; Naoyasu Umeda; Jikui Shen; Aling Dong; Rajendra S Apte; Elia J Duh; Sean F Hackett; Godwin Okoye; Kazuki Ishibashi; James T Handa; Michele Melia; Stanley J Wiegand; George D Yancopoulos; Donald J Zack; Peter A Campochiaro
Different effects of angiopoietin-2 in different vascular beds: new vessels are most sensitive.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(8):963-5.
2005: Anne Kasus-Jacobi; Jiafu Ou; David G Birch; Kirsten G Locke; John M Shelton; James A Richardson; Andrew J Murphy; David M Valenzuela; George D Yancopoulos; Albert O Edwards
Functional characterization of mouse RDH11 as a retinol dehydrogenase involved in dark adaptation in vivo.
The Journal of biological chemistry 2005;280(21):20413-20.
2005: Gloria B Choi; Hong-Wei Dong; Andrew J Murphy; David M Valenzuela; George D Yancopoulos; Larry W Swanson; David J Anderson
Lhx6 delineates a pathway mediating innate reproductive behaviors from the amygdala to the hypothalamus.
Neuron 2005;46(4):647-60.
2005: Lynn E Macdonald; Katherine E Wortley; Lori C Gowen; Keith D Anderson; Jane D Murray; William T Poueymirou; Mary V Simmons; Dianna Barber; David M Valenzuela; Aris N Economides; Stanley J Wiegand; George D Yancopoulos; Mark W Sleeman; Andrew J Murphy
Resistance to diet-induced obesity in mice globally overexpressing OGH/GPB5.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(7):2496-501.
2005: Mark W Sleeman; Katherine E Wortley; Ka-Man V Lai; Lori C Gowen; Jennifer Kintner; William O Kline; Karen Garcia; Trevor N Stitt; George D Yancopoulos; Stanley J Wiegand; David J Glass
Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity.
Nature medicine 2005;11(2):199-205.
2005: Esther Latres; Ami R Amini; Ashley A Amini; Jennifer Griffiths; Francis J Martin; Yi Wei; Hsin Chieh Lin; George D Yancopoulos; David J Glass
Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway.
The Journal of biological chemistry 2005;280(4):2737-44.
2005: John S Rudge; G Thurston; S Davis; N Papadopoulos; nicholas gale; Stanley J Wiegand; George D Yancopoulos
VEGF trap as a novel antiangiogenic treatment currently in clinical trials for cancer and eye diseases, and VelociGene- based discovery of the next generation of angiogenesis targets.
Cold Spring Harbor symposia on quantitative biology 2005;70():411-8.
2005: Gavin Thurston; John S Rudge; Ella Ioffe; Nick Papadopoulos; Christopher Daly; Srilatha Vuthoori; Thomas J Daly; Stanley J Wiegand; George D Yancopoulos
The anti-inflammatory actions of angiopoietin-1.
EXS 2005;(94):233-45.
2004: Jolanta Pitera; Adrian S Woolf; nicholas gale; George D Yancopoulos; Hai-Tao Yuan
Dysmorphogenesis of kidney cortical peritubular capillaries in angiopoietin-2-deficient mice.
The American journal of pathology 2004;165(6):1895-906.
2004: nicholas gale; Melissa G Dominguez; Irene Noguera-Troise; Li Pan; Virginia Hughes; David M Valenzuela; Andrew J Murphy; Niels Adams; Hsin Chieh Lin; Jocelyn Holash; Gavin Thurston; George D Yancopoulos
Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(45):15949-54.
2004: Ka-Man V Lai; Michael Gonzalez; William T Poueymirou; William O Kline; Erqian Na; Elizabeth Zlotchenko; Trevor N Stitt; Aris N Economides; George D Yancopoulos; David J Glass
Conditional activation of akt in adult skeletal muscle induces rapid hypertrophy.
Molecular and cellular biology 2004;24(21):9295-304.
2004: Jason S Frischer; Jianzhong Huang; Anna Serur; Angela Kadenhe-Chiweshe; Kimberly McCrudden; Kathleen O'Toole; Jocelyn Holash; George D Yancopoulos; Darrell J Yamashiro; Jessica J Kandel
Effects of potent VEGF blockade on experimental Wilms tumor and its persisting vasculature.
International journal of oncology 2004;25(3):549-53.
2004: Yi Fu Zhou; Eugenio Stabile; Jill Walker; Matie Shou; Richard Baffour; Zuxi Yu; David Rott; George D Yancopoulos; John S Rudge; Stephen E Epstein
Effects of gene delivery on collateral development in chronic hypoperfusion: diverse effects of angiopoietin-1 versus vascular endothelial growth factor.
Journal of the American College of Cardiology 2004;44(4):897-903.
2004: Tetsuichiro Inai; Michael Mancuso; Hiroya Hashizume; Fabienne Baffert; Amy Haskell; Peter Baluk; Dana Hu-Lowe; David R Shalinsky; Gavin Thurston; George D Yancopoulos; Donald M McDonald
Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts.
The American journal of pathology 2004;165(1):35-52.
2004: Susan D Croll; Richard M Ransohoff; Ning Cai; Qing Zhang; Francis J Martin; Tao Wei; Lora J Kasselman; Jennifer Kintner; Andrew J Murphy; George D Yancopoulos; Stanley J Wiegand
VEGF-mediated inflammation precedes angiogenesis in adult brain.
Experimental neurology 2004;187(2):388-402.
2004: Katherine E Wortley; Keith D Anderson; Karen Garcia; Jane D Murray; Lubomira Malinova; Rong Liu; Marshena Moncrieffe; Karen Thabet; Hilary J Cox; George D Yancopoulos; Stanley J Wiegand; Mark W Sleeman
Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(21):8227-32.
2004: Trevor N Stitt; Doreen Drujan; Brian A Clarke; Frank J Panaro; Yekatarina Timofeyva; William O Kline; Michael Gonzalez; George D Yancopoulos; David J Glass
The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors.
Molecular cell 2004;14(3):395-403.
2004: Christopher Daly; Vivian Wong; Elena Burova; Yi Wei; Stephanie Zabski; Jennifer Griffiths; Ka-Man Lai; Hsin Chieh Lin; Ella Ioffe; George D Yancopoulos; John S Rudge
Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1).
Genes & development 2004;18(9):1060-71.
2004: Hiroyuki Nambu; Rie Nambu; Yuji Oshima; Sean F Hackett; Godwin Okoye; Stanley J Wiegand; George D Yancopoulos; Donald J Zack; Peter A Campochiaro
Angiopoietin 1 inhibits ocular neovascularization and breakdown of the blood-retinal barrier.
Gene therapy 2004;11(10):865-73.
2004: David A Feldheim; Masaru Nakamoto; Miriam Osterfield; nicholas gale; Thomas M DeChiara; Rajat Rohatgi; George D Yancopoulos; John G Flanagan
Loss-of-function analysis of EphA receptors in retinotectal mapping.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(10):2542-50.
2004: Jianzhong Huang; Jason S Frischer; Tamara New; Eugene S Kim; Anna Serur; Alice Lee; Angela Kadenhe-Chiwishe; Daniel A Pollyea; Akiko Yokoi; Jocelyn Holash; George D Yancopoulos; Jessica J Kandel; Darrell J Yamashiro
TNP-470 promotes initial vascular sprouting in xenograft tumors.
Molecular cancer therapeutics 2004;3(3):335-43.
2004: Caroline Saucier; Hanane Khoury; Ka-Man Venus Lai; Pascal Peschard; David Dankort; Monica A Naujokas; Jocelyn Holash; George D Yancopoulos; William J Muller; Tony Pawson; Morag Park
The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(8):2345-50.
2003: Mark W Sleeman; Karen Garcia; Rong Liu; Jane D Murray; L Malinova; M Moncrieffe; George D Yancopoulos; Stanley J Wiegand
Ciliary neurotrophic factor improves diabetic parameters and hepatic steatosis and increases basal metabolic rate in db/db mice.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):14297-302.
2003: Annette T Byrne; Leorah Ross; Jocelyn Holash; Mikiye Nakanishi; Limin Hu; Judith Hofmann; George D Yancopoulos; Robert B Jaffe
Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(15):5721-8.
2003: Rania Harfouche; Jean-Philippe Gratton; George D Yancopoulos; Michela Noseda; Aly Karsan; Sabah N A Hussain
Angiopoietin-1 activates both anti- and proapoptotic mitogen-activated protein kinases.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(11):1523-5.
2003: Keith D Anderson; PD Lambert; TL Corcoran; Jane D Murray; Karen Thabet; George D Yancopoulos; Stanley J Wiegand
Activation of the hypothalamic arcuate nucleus predicts the anorectic actions of ciliary neurotrophic factor and leptin in intact and gold thioglucose-lesioned mice.
Journal of neuroendocrinology 2003;15(7):649-60.
2003: Yu-Ping Xia; Baosheng Li; Donna Hylton; Michael Detmar; George D Yancopoulos; John S Rudge
Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasis.
Blood 2003;102(1):161-8.
2003: Jianzhong Huang; Jason S Frischer; Anna Serur; Angela Kadenhe; Akiko Yokoi; Kimberly McCrudden; Tamara New; Kathleen O'Toole; Stephanie Zabski; John S Rudge; Jocelyn Holash; George D Yancopoulos; Darrell J Yamashiro; Jessica J Kandel
Regression of established tumors and metastases by potent vascular endothelial growth factor blockade.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(13):7785-90.
2003: Fernando Larcher; Marcela Franco; Marcela Bolontrade; Marcelo L Rodriguez-Puebla; Llanos Casanova; Manuel Navarro; George D Yancopoulos; José L Jorcano; Claudio J Conti
Modulation of the angiogenesis response through Ha-ras control, placenta growth factor, and angiopoietin expression in mouse skin carcinogenesis.
Molecular carcinogenesis 2003;37(2):83-90.
2003: David M Valenzuela; Andrew J Murphy; David Frendewey; nicholas gale; Aris N Economides; Wojtek Auerbach; William T Poueymirou; Niels Adams; Jose Rojas; Jason Yasenchak; Rostislav Chernomorsky; Marylene Boucher; Andrea L Elsasser; Lakeisha Esau; Jenny Zheng; Jennifer A Griffiths; Xiaorong Wang; Hong Su; Yingzi Xue; Melissa G Dominguez; Irene Noguera-Troise; Richard Torres; Lynn E Macdonald; A Francis Stewart; Thomas M DeChiara; George D Yancopoulos
High-throughput engineering of the mouse genome coupled with high-resolution expression analysis.
Nature biotechnology 2003;21(6):652-9.
2003: John S Rudge; G Thurston; George D Yancopoulos
Angiopoietin-1 and pulmonary hypertension: cause or cure?
Circulation research 2003;92(9):947-9.
2003: Pat P Ongusaha; Jong-il Kim; Li Fang; Tze Wai Wong; George D Yancopoulos; Stuart A Aaronson; Sam W Lee
p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop.
The EMBO journal 2003;22(6):1289-301.
2003: Antonia M Joussen; Vassiliki Poulaki; Nicholas Mitsiades; Stephen U Stechschulte; Bernd Kirchhof; Darlene A Dartt; Guo-Hua Fong; John S Rudge; Stanley J Wiegand; George D Yancopoulos; Anthony P Adamis
VEGF-dependent conjunctivalization of the corneal surface.
Investigative ophthalmology & visual science 2003;44(1):117-23.
2003: Aris N Economides; Laura Rocco Carpenter; John S Rudge; Vivien Wong; Ellen M Koehler-Stec; Christopher Hartnett; Erica A Pyles; Xiaobing Xu; Thomas J Daly; Michael R Young; James P Fandl; Frank Lee; Scott Carver; Jennifer McNay; Kevin Bailey; Swayampakula Ramakanth; Renta Hutabarat; Tammy T Huang; Czeslaw Radziejewski; George D Yancopoulos; Neil stahl
Cytokine traps: multi-component, high-affinity blockers of cytokine action.
Nature medicine 2003;9(1):47-52.
2003: Samuel Davis; Nick Papadopoulos; Thomas H Aldrich; Peter C Maisonpierre; Tammy Huang; Lubomir Kovac; April Xu; Raymond Leidich; Elzbieta Radziejewska; Ashique Rafique; Judah Goldberg; Vivek Jain; Kevin Bailey; Margaret Karow; James P Fandl; Steven J Samuelsson; Ella Ioffe; John S Rudge; Thomas J Daly; Czeslaw Radziejewski; George D Yancopoulos
Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering.
Nature structural biology 2003;10(1):38-44.
2002: Akiyoshi Uemura; Minetaro Ogawa; Masanori Hirashima; Takashi Fujiwara; Shinji Koyama; Hitoshi Takagi; Yoshihito Honda; Stanley J Wiegand; George D Yancopoulos; Shin-Ichi Nishikawa
Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells.
The Journal of clinical investigation 2002;110(11):1619-28.
2002: Nikki Cheng; Dana M Brantley; Hua Liu; Qin Lin; Miriam Enriquez; nicholas gale; George D Yancopoulos; Douglas Pat Cerretti; Thomas O Daniel; Jin Chen
Blockade of EphA receptor tyrosine kinase activation inhibits vascular endothelial cell growth factor-induced angiogenesis.
Molecular cancer research : MCR 2002;1(1):2-11.
2002: nicholas gale; Gavin Thurston; Sean F Hackett; Roumiana Renard; Quan Wang; Joyce McClain; Cliff Martin; Charles L Witte; Marlys H Witte; David Jackson; Chitra Suri; Peter A Campochiaro; Stanley J Wiegand; George D Yancopoulos
Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1.
Developmental cell 2002;3(3):411-23.
2002: Eugene S Kim; Anna Serur; Jianzhong Huang; Christina A Manley; Kimberly McCrudden; Jason S Frischer; Samuel Soffer; Laurence Ring; Tamara New; Stephanie Zabski; John S Rudge; Jocelyn Holash; George D Yancopoulos; Jessica J Kandel; Darrell J Yamashiro
Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11399-404.
2002: Jocelyn Holash; Sam Davis; Nick Papadopoulos; Susan D Croll; Lillian Ho; Michelle Russell; Patricia Boland; Raymond Leidich; Donna Hylton; Elena Burova; Ella Ioffe; Tammy Huang; Czeslaw Radziejewski; Kevin Bailey; James P Fandl; Thomas J Daly; Stanley J Wiegand; George D Yancopoulos; John S Rudge
VEGF-Trap: a VEGF blocker with potent antitumor effects.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11393-8.
2002: Yong Yue; Zhi-Yong Chen; nicholas gale; Jan Blair-Flynn; Tian-Jing Hu; Xin Yue; Margaret Cooper; David P Crockett; George D Yancopoulos; Lino Tessarollo; Renping Zhou
Mistargeting hippocampal axons by expression of a truncated Eph receptor.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10777-82.
2002: Sean F Hackett; Stanley J Wiegand; George D Yancopoulos; Peter A Campochiaro
Angiopoietin-2 plays an important role in retinal angiogenesis.
Journal of cellular physiology 2002;192(2):182-7.
2002: Rania Harfouche; Haroutioun M Hasséssian; Yang Guo; Valérie Faivre; Coimbatore B Srikant; George D Yancopoulos; Sabah N A Hussain
Mechanisms which mediate the antiapoptotic effects of angiopoietin-1 on endothelial cells.
Microvascular research 2002;64(1):135-47.
2002: Injune Kim; Young Shin Ryu; Hee Jin Kwak; So Young Ahn; Jong-Lark Oh; George D Yancopoulos; nicholas gale; Gou Young Koh
EphB ligand, ephrinB2, suppresses the VEGF- and angiopoietin 1-induced Ras/mitogen-activated protein kinase pathway in venous endothelial cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(9):1126-8.
2002: Kazuo Ikeda; Li-Hsien Wang; Richard Torres; Hong Zhao; Elvira Olaso; Francis J Eng; Pablo Labrador; Rudiger Klein; David Lovett; George D Yancopoulos; Scott L Friedman; Hsin Chieh Lin
Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen.
The Journal of biological chemistry 2002;277(21):19206-12.
2002: Antonia M Joussen; Vassiliki Poulaki; Akitaka Tsujikawa; Wenying Qin; Tamim Qaum; Qingwen Xu; Yasufumi Moromizato; Sven-Erik Bursell; Stanley J Wiegand; John S Rudge; Ella Ioffe; George D Yancopoulos; Anthony P Adamis
Suppression of diabetic retinopathy with angiopoietin-1.
The American journal of pathology 2002;160(5):1683-93.
2002: Vassiliki Poulaki; Wenying Qin; Antonia M Joussen; Peter Hurlbut; Stanley J Wiegand; John S Rudge; George D Yancopoulos; Anthony P Adamis
Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1alpha and VEGF.
The Journal of clinical investigation 2002;109(6):805-15.
2002: Antonia M Joussen; Vassiliki Poulaki; Wenying Qin; Bernd Kirchhof; Nicholas Mitsiades; Stanley J Wiegand; John S Rudge; George D Yancopoulos; Anthony P Adamis
Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo.
The American journal of pathology 2002;160(2):501-9.
2002: nicholas gale; Gavin Thurston; S Davis; Stanley J Wiegand; Jocelyn Holash; John S Rudge; George D Yancopoulos
Complementary and coordinated roles of the VEGFs and angiopoietins during normal and pathologic vascular formation.
Cold Spring Harbor symposia on quantitative biology 2002;67():267-73.
2001: Sue Bodine; Esther Latres; S Baumhueter; V K Lai; Lorna Nunez; Brian A Clarke; William T Poueymirou; Frank J Panaro; E Na; K Dharmarajan; Z Q Pan; David M Valenzuela; Thomas M DeChiara; Trevor N Stitt; George D Yancopoulos; David J Glass
Identification of ubiquitin ligases required for skeletal muscle atrophy.
Science (New York, N.Y.) 2001;294(5547):1704-8.
2001: Sue Bodine; Trevor N Stitt; Michael Gonzalez; William O Kline; G L Stover; R Bauerlein; Elizabeth Zlotchenko; Angus Scrimgeour; John C Lawrence; David J Glass; George D Yancopoulos
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo.
Nature cell biology 2001;3(11):1014-9.
2001: C Rommel; Sue Bodine; Brian A Clarke; R Rossman; Lorna Nunez; Trevor N Stitt; George D Yancopoulos; David J Glass
Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways.
Nature cell biology 2001;3(11):1009-13.
2001: Tamim Qaum; Qingwen Xu; Antonia M Joussen; M W Clemens; W Qin; K Miyamoto; H Hassessian; Stanley J Wiegand; John S Rudge; George D Yancopoulos; Anthony P Adamis
VEGF-initiated blood-retinal barrier breakdown in early diabetes.
Investigative ophthalmology & visual science 2001;42(10):2408-13.
2001: Xiu-Qin Zhang; Nobuyuki Takakura; Yuichi Oike; Tomohisa Inada; nicholas gale; George D Yancopoulos; Toshio Suda
Stromal cells expressing ephrin-B2 promote the growth and sprouting of ephrin-B2(+) endothelial cells.
Blood 2001;98(4):1028-37.
2001: Juan-Pablo Labrador; V Azcoitia; Jan P Tuckermann; C Lin; Elvira Olaso; Santos Mañes; K Brückner; J L Goergen; G Lemke; George D Yancopoulos; Peter Angel; C Martínez; Rudiger Klein
The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism.
EMBO reports 2001;2(5):446-52.
2001: J Terrado; Robert W Burgess; Thomas M DeChiara; George D Yancopoulos; Joshua R Sanes; Ann C Kato
Motoneuron survival is enhanced in the absence of neuromuscular junction formation in embryos.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(9):3144-50.
2001: PD Lambert; Keith D Anderson; Mark W Sleeman; V Wong; J Tan; A Hijarunguru; TL Corcoran; Jane D Murray; Karen Thabet; George D Yancopoulos; Stanley J Wiegand
Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(8):4652-7.
2001: K Kullander; Susan D Croll; M Zimmer; L Pan; Joyce McClain; V Hughes; Stephanie Zabski; Thomas M DeChiara; Rudiger Klein; George D Yancopoulos; nicholas gale
Ephrin-B3 is the midline barrier that prevents corticospinal tract axons from recrossing, allowing for unilateral motor control.
Genes & development 2001;15(7):877-88.
2001: nicholas gale; P Baluk; L Pan; Marilyn L. Kwan; Jocelyn Holash; Thomas M DeChiara; Donald M McDonald; George D Yancopoulos
Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells.
Developmental biology 2001;230(2):151-60.
2000: Fanny C F Ip; D G Glass; D R Gies; Janet Cheung; Kwok-On Lai; Amy K Y Fu; George D Yancopoulos; Nancy Y Ip
Cloning and characterization of muscle-specific kinase in chicken.
Molecular and cellular neurosciences 2000;16(5):661-73.
2000: J C Conover; Fiona Doetsch; Jose Manuel Garcia-Verdugo; nicholas gale; George D Yancopoulos; Arturo Alvarez-Buylla
Disruption of Eph/ephrin signaling affects migration and proliferation in the adult subventricular zone.
Nature neuroscience 2000;3(11):1091-7.
2000: George D Yancopoulos; S Davis; nicholas gale; John S Rudge; Stanley J Wiegand; Jocelyn Holash
Vascular-specific growth factors and blood vessel formation.
Nature 2000;407(6801):242-8.
2000: Sean F Hackett; H Ozaki; R W Strauss; Karl Wahlin; Chitra Suri; Peter C Maisonpierre; George D Yancopoulos; Peter A Campochiaro
Angiopoietin 2 expression in the retina: upregulation during physiologic and pathologic neovascularization.
Journal of cellular physiology 2000;184(3):275-84.
2000: David Zagzag; David R Friedlander; Benjamin L Margolis; Martin Grumet; Gregg L Semenza; Hua Zhong; Jonathan W Simons; Jocelyn Holash; Stanley J Wiegand; George D Yancopoulos
Molecular events implicated in brain tumor angiogenesis and invasion.
Pediatric neurosurgery 2000;33(1):49-55.
2000: David Zagzag; R Amirnovin; M A Greco; Herman Yee; Jocelyn Holash; Stanley J Wiegand; Stephanie Zabski; George D Yancopoulos; Martin Grumet
Vascular apoptosis and involution in gliomas precede neovascularization: a novel concept for glioma growth and angiogenesis.
Laboratory investigation; a journal of technical methods and pathology 2000;80(6):837-49.
2000: Hai-Tao Yuan; C Suri; D N Landon; George D Yancopoulos; Adrian S Woolf
Angiopoietin-2 is a site-specific factor in differentiation of mouse renal vasculature.
Journal of the American Society of Nephrology : JASN 2000;11(6):1055-66.
2000: RC Marcus; G A Matthews; nicholas gale; George D Yancopoulos; Carol A Mason
Axon guidance in the mouse optic chiasm: retinal neurite inhibition by ephrin "A"-expressing hypothalamic cells in vitro.
Developmental biology 2000;221(1):132-47.
2000: Gavin Thurston; John S Rudge; Ella Ioffe; H Zhou; L Ross; Susan D Croll; N Glazer; Jocelyn Holash; Donald M McDonald; George D Yancopoulos
Angiopoietin-1 protects the adult vasculature against plasma leakage.
Nature medicine 2000;6(4):460-3.
2000: Mark W Sleeman; Keith D Anderson; PD Lambert; George D Yancopoulos; Stanley J Wiegand
The ciliary neurotrophic factor and its receptor, CNTFR alpha.
Pharmaceutica acta Helvetiae 2000;74(2-3):265-72.
2000: Michael Oldridge; A M Fortuna; M Maringa; P Propping; S Mansour; C Pollitt; Thomas M DeChiara; R B Kimble; David M Valenzuela; George D Yancopoulos; Andrew O M Wilkie
Dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B.
Nature genetics 2000;24(3):275-8.
2000: Thomas M DeChiara; R B Kimble; William T Poueymirou; Jose Rojas; Piotr Masiakowski; David M Valenzuela; George D Yancopoulos
Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development.
Nature genetics 2000;24(3):271-4.
1999: Gavin Thurston; Chitra Suri; K Smith; Joyce McClain; TN Sato; George D Yancopoulos; Donald M McDonald
Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1.
Science (New York, N.Y.) 1999;286(5449):2511-4.
1999: C Rommel; Brian A Clarke; Sven Zimmermann; L Nuñez; R Rossman; K Reid; Karin Moelling; George D Yancopoulos; David J Glass
Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.
Science (New York, N.Y.) 1999;286(5445):1738-41.
1999: David Zagzag; A Hooper; David R Friedlander; Wai Chan; Jocelyn Holash; Stanley J Wiegand; George D Yancopoulos; Martin Grumet
In situ expression of angiopoietins in astrocytomas identifies angiopoietin-2 as an early marker of tumor angiogenesis.
Experimental neurology 1999;159(2):391-400.
1999: Jocelyn Holash; Stanley J Wiegand; George D Yancopoulos
New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF.
Oncogene 1999;18(38):5356-62.
1999: H Zhou; D J Glass; George D Yancopoulos; Joshua R Sanes
Distinct domains of MuSK mediate its abilities to induce and to associate with postsynaptic specializations.
The Journal of cell biology 1999;146(5):1133-46.
1999: Hai-Tao Yuan; C Suri; George D Yancopoulos; Adrian S Woolf
Expression of angiopoietin-1, angiopoietin-2, and the Tie-2 receptor tyrosine kinase during mouse kidney maturation.
Journal of the American Society of Nephrology : JASN 1999;10(8):1722-36.
1999: Jocelyn Holash; Peter C Maisonpierre; D Compton; P Boland; C R Alexander; David Zagzag; George D Yancopoulos; Stanley J Wiegand
Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF.
Science (New York, N.Y.) 1999;284(5422):1994-8.
1999: M Gautam; Thomas M DeChiara; David J Glass; George D Yancopoulos; Joshua R Sanes
Distinct phenotypes of mutant mice lacking agrin, MuSK, or rapsyn.
Brain research. Developmental brain research 1999;114(2):171-8.
1999: nicholas gale; George D Yancopoulos
Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development.
Genes & development 1999;13(9):1055-66.
1999: David M Valenzuela; J A Griffiths; Jose Rojas; Thomas H Aldrich; Pam Jones; H Zhou; Joyce McClain; N G Copeland; D J Gilbert; N A Jenkins; Tammy Huang; Nick Papadopoulos; Peter C Maisonpierre; Samuel Davis; George D Yancopoulos
Angiopoietins 3 and 4: diverging gene counterparts in mice and humans.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):1904-9.
1999: JR Tonra; M Ono; X Liu; Karen Garcia; C Jackson; George D Yancopoulos; Stanley J Wiegand; V Wong
Brain-derived neurotrophic factor improves blood glucose control and alleviates fasting hyperglycemia in C57BLKS-Lepr(db)/lepr(db) mice.
Diabetes 1999;48(3):588-94.
1999: D K Binder; Mark J Routbort; Terence Edward Ryan; George D Yancopoulos; James O McNamara
Selective inhibition of kindling development by intraventricular administration of TrkB receptor body.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(4):1424-36.
1999: Andreas Papapetropoulos; Guillermo García-Cardeña; T J Dengler; P C Maisonpierre; George D Yancopoulos; William C Sessa
Direct actions of angiopoietin-1 on human endothelium: evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors.
Laboratory investigation; a journal of technical methods and pathology 1999;79(2):213-23.
1999: Susan D Croll; Chitra Suri; D L Compton; M V Simmons; George D Yancopoulos; RM Lindsay; Stanley J Wiegand; John S Rudge; Helen E Scharfman
Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex.
Neuroscience 1999;93(4):1491-506.
1999: Konstantina Grosios; Jack P Leek; Alexander F Markham; George D Yancopoulos; Pam Jones
Assignment of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3-->q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping.
Cytogenetics and cell genetics 1999;84(1-2):118-20.
1999: S Davis; George D Yancopoulos
The angiopoietins: Yin and Yang in angiogenesis.
Current topics in microbiology and immunology 1999;237():173-85.
1998: R Torres; B L Firestein; H Dong; J Staudinger; E N Olson; Richard Huganir; D S Bredt; nicholas gale; George D Yancopoulos
PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands.
Neuron 1998;21(6):1453-63.
1998: Chitra Suri; Joyce McClain; Gavin Thurston; Donald M McDonald; H Zhou; E H Oldmixon; TN Sato; George D Yancopoulos
Increased vascularization in mice overexpressing angiopoietin-1.
Science (New York, N.Y.) 1998;282(5388):468-71.
1998: Joachim Weis; DC Lie; U Ragoss; Stephan Zuchner; J Michael Schröder; G Karpati; TJ Farruggella; Neil stahl; George D Yancopoulos; P S DiStefano
Increased expression of CNTF receptor alpha in denervated human skeletal muscle.
Journal of neuropathology and experimental neurology 1998;57(9):850-7.
1998: P Lin; J A Buxton; A Acheson; Czeslaw Radziejewski; Peter C Maisonpierre; George D Yancopoulos; KM Channon; Laura P Hale; Mark Dewhirst; Samuel E George; Kevin G Peters
Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(15):8829-34.
1998: D C Bowen; JS Park; Sue Bodine; J L Stark; David M Valenzuela; Trevor N Stitt; George D Yancopoulos; RM Lindsay; David J Glass; PS DiStefano
Localization and regulation of MuSK at the neuromuscular junction.
Developmental biology 1998;199(2):309-19.
1998: Joshua R Sanes; Elizabeth D Apel; Robert W Burgess; R B Emerson; Guoping Feng; M Gautam; D Glass; R Mark Grady; krejci eric; Jeff W Lichtman; J T Lu; Jean Massoulié; Jeffrey H Miner; LM Moscoso; Q Nguyen; MC Nichol; Peter G Noakes; Bruce L Patton; YJ Son; George D Yancopoulos; H Zhou
Development of the neuromuscular junction: genetic analysis in mice.
Journal of physiology, Paris 1998;92(3-4):167-72.
1998: George D Yancopoulos; M Klagsbrun; J Folkman
Vasculogenesis, angiogenesis, and growth factors: ephrins enter the fray at the border.
Cell 1998;93(5):661-4.
1998: Laura Rocco Carpenter; TJ Farruggella; AJ Symes; M L Karow; George D Yancopoulos; Neil stahl
Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(11):6061-6.
1998: Joshua R Sanes; Elizabeth D Apel; M Gautam; D Glass; R Mark Grady; PT Martin; MC Nichol; George D Yancopoulos
Agrin receptors at the skeletal neuromuscular junction.
Annals of the New York Academy of Sciences 1998;841():1-13.
1998: Pam Jones; Joyce McClain; D M Robinson; T N Sato; George D Yancopoulos
Identification and characterisation of chicken cDNAs encoding the endothelial cell-specific receptor tyrosine kinase Tie2 and its ligands, the angiopoietins.
Angiogenesis 1998;2(4):357-64.
1998: Laura Rocco Carpenter; George D Yancopoulos; Neil stahl
General mechanisms of cytokine receptor signaling.
Advances in protein chemistry 1998;52():109-40.
1997: A Shrivastava; Czeslaw Radziejewski; E Campbell; Lubomir Kovac; M McGlynn; Terence Edward Ryan; S Davis; mitchell goldfarb; D J Glass; G Lemke; George D Yancopoulos
An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors.
Molecular cell 1997;1(1):25-34.
1997: Beth A Habecker; AJ Symes; Neil stahl; Nicole Francis; Aris N Economides; J Stephen Fink; George D Yancopoulos; Story C Landis
A sweat gland-derived differentiation activity acts through known cytokine signaling pathways.
The Journal of biological chemistry 1997;272(48):30421-8.
1997: nicholas gale; George D Yancopoulos
Ephrins and their receptors: a repulsive topic?
Cell and tissue research 1997;290(2):227-41.
1997: Azad Bonni; Yi E Sun; M Nadal-Vicens; A Bhatt; David A Frank; I Rozovsky; Neil stahl; George D Yancopoulos; Michael E Greenberg
Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway.
Science (New York, N.Y.) 1997;278(5337):477-83.
1997: AJ Symes; Neil stahl; Steven A Reeves; TJ Farruggella; T Servidei; Tom Gearan; George D Yancopoulos; J Stephen Fink
The protein tyrosine phosphatase SHP-2 negatively regulates ciliary neurotrophic factor induction of gene expression.
Current biology : CB 1997;7(9):697-700.
1997: David J Glass; Elizabeth D Apel; S Shah; D C Bowen; Thomas M DeChiara; Trevor N Stitt; Joshua R Sanes; George D Yancopoulos
Kinase domain of the muscle-specific receptor tyrosine kinase (MuSK) is sufficient for phosphorylation but not clustering of acetylcholine receptors: required role for the MuSK ectodomain?
Proceedings of the National Academy of Sciences of the United States of America 1997;94(16):8848-53.
1997: CE Krull; Rusty Lansford; nicholas gale; A Collazo; Christophe Marcelle; George D Yancopoulos; Scott E Fraser; Marianne Bronner-Fraser
Interactions of Eph-related receptors and ligands confer rostrocaudal pattern to trunk neural crest migration.
Current biology : CB 1997;7(8):571-80.
1997: Peter C Maisonpierre; Chitra Suri; Pam Jones; S Bartunkova; Stanley J Wiegand; Czeslaw Radziejewski; D Compton; Joyce McClain; Thomas H Aldrich; Nick Papadopoulos; Thomas J Daly; Samuel Davis; TN Sato; George D Yancopoulos
Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis.
Science (New York, N.Y.) 1997;277(5322):55-60.
1997: SJ Holland; nicholas gale; Gerald Gish; R A Roth; Zhou Songyang; L C Cantley; Mark Henkemeyer; George D Yancopoulos; Tony Pawson
Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells.
The EMBO journal 1997;16(13):3877-88.
1997: Elizabeth D Apel; David J Glass; LM Moscoso; George D Yancopoulos; Joshua R Sanes
Rapsyn is required for MuSK signaling and recruits synaptic components to a MuSK-containing scaffold.
Neuron 1997;18(4):623-35.
1997: Z D Ezzeddine; X Yang; Thomas M DeChiara; George D Yancopoulos; Constance L Cepko
Postmitotic cells fated to become rod photoreceptors can be respecified by CNTF treatment of the retina.
Development (Cambridge, England) 1997;124(5):1055-67.
1997: V Wong; David J Glass; R Arriaga; George D Yancopoulos; RM Lindsay; G Conn
Hepatocyte growth factor promotes motor neuron survival and synergizes with ciliary neurotrophic factor.
The Journal of biological chemistry 1997;272(8):5187-91.
1996: Chitra Suri; Pam Jones; S Patan; S Bartunkova; Peter C Maisonpierre; Samuel Davis; TN Sato; George D Yancopoulos
Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis.
Cell 1996;87(7):1171-80.
1996: Samuel Davis; Thomas H Aldrich; Pam Jones; AL Acheson; D L Compton; V Jain; Terence Edward Ryan; J Bruno; Czeslaw Radziejewski; Peter C Maisonpierre; George D Yancopoulos
Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning.
Cell 1996;87(7):1161-9.
1996: R C Marcus; nicholas gale; M E Morrison; Carol A Mason; George D Yancopoulos
Eph family receptors and their ligands distribute in opposing gradients in the developing mouse retina.
Developmental biology 1996;180(2):786-9.
1996: Kwok-On Lai; David J Glass; D Geis; George D Yancopoulos; Nancy Y Ip
Structural determinants of Trk receptor specificities using BDNF-based neurotrophin chimeras.
Journal of neuroscience research 1996;46(5):618-29.
1996: A M Flenniken; nicholas gale; George D Yancopoulos; David George Wilkinson
Distinct and overlapping expression patterns of ligands for Eph-related receptor tyrosine kinases during mouse embryogenesis.
Developmental biology 1996;179(2):382-401.
1996: SJ Holland; nicholas gale; Geraldine Mbamalu; George D Yancopoulos; Mark Henkemeyer; Tony Pawson
Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands.
Nature 1996;383(6602):722-5.
1996: RM Lindsay; George D Yancopoulos
GDNF in a bind with known orphan: accessory implicated in new twist.
Neuron 1996;17(4):571-4.
1996: nicholas gale; A Flenniken; D C Compton; N Jenkins; N G Copeland; D J Gilbert; Samuel Davis; David George Wilkinson; George D Yancopoulos
Elk-L3, a novel transmembrane ligand for the Eph family of receptor tyrosine kinases, expressed in embryonic floor plate, roof plate and hindbrain segments.
Oncogene 1996;13(6):1343-52.
1996: J T Erickson; J C Conover; V Borday; J Champagnat; M Barbacid; George D Yancopoulos; David M Katz
Mice lacking brain-derived neurotrophic factor exhibit visceral sensory neuron losses distinct from mice lacking NT4 and display a severe developmental deficit in control of breathing.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(17):5361-71.
1996: nicholas gale; SJ Holland; David M Valenzuela; A Flenniken; L Pan; Terence Edward Ryan; Mark Henkemeyer; K Strebhardt; H Hirai; David George Wilkinson; Tony Pawson; Samuel Davis; George D Yancopoulos
Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis.
Neuron 1996;17(1):9-19.
1996: L M Bianchi; J C Conover; B Fritzsch; Thomas M DeChiara; RM Lindsay; George D Yancopoulos
Degeneration of vestibular neurons in late embryogenesis of both heterozygous and homozygous BDNF null mutant mice.
Development (Cambridge, England) 1996;122(6):1965-73.
1996: David J Glass; D C Bowen; Trevor N Stitt; Czeslaw Radziejewski; J Bruno; Terence Edward Ryan; D R Gies; S Shah; K Mattsson; S J Burden; PS DiStefano; David M Valenzuela; Thomas M DeChiara; George D Yancopoulos
Agrin acts via a MuSK receptor complex.
Cell 1996;85(4):513-23.
1996: Thomas M DeChiara; D C Bowen; David M Valenzuela; M V Simmons; W T Poueymirou; S Thomas; E Kinetz; D L Compton; E Rojas; JS Park; C Smith; PS DiStefano; David J Glass; S J Burden; George D Yancopoulos
The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo.
Cell 1996;85(4):501-12.
1996: M Faris; B Ensoli; Neil stahl; George D Yancopoulos; A Nguyen; S Wang; Andre E Nel
Differential activation of the extracellular signal-regulated kinase, Jun kinase and Janus kinase-Stat pathways by oncostatin M and basic fibroblast growth factor in AIDS-derived Kaposi's sarcoma cells.
AIDS (London, England) 1996;10(4):369-78.
1996: Teresita Bellido; Neil stahl; T J Farruggella; V Borba; George D Yancopoulos; Stavros C Manolagas
Detection of receptors for interleukin-6, interleukin-11, leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor in bone marrow stromal/osteoblastic cells.
The Journal of clinical investigation 1996;97(2):431-7.
1996: David J Glass; Thomas M DeChiara; Trevor N Stitt; PS DiStefano; David M Valenzuela; George D Yancopoulos
The receptor tyrosine kinase MuSK is required for neuromuscular junction formation and is a functional receptor for agrin.
Cold Spring Harbor symposia on quantitative biology 1996;61():435-44.
1996: Nancy Y Ip; George D Yancopoulos
The neurotrophins and CNTF: two families of collaborative neurotrophic factors.
Annual review of neuroscience 1996;19():491-515.
1995: Aris N Economides; J V Ravetch; George D Yancopoulos; Neil stahl
Designer cytokines: targeting actions to cells of choice.
Science (New York, N.Y.) 1995;270(5240):1351-3.
1995: Thomas M DeChiara; R Vejsada; W T Poueymirou; AL Acheson; Chitra Suri; J C Conover; B Friedman; Joyce McClain; L Pan; Neil stahl; Nancy Y Ip; George D Yancopoulos
Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth.
Cell 1995;83(2):313-22.
1995: T G Boulton; Z Zhong; Z Wen; James E Darnell; Neil stahl; George D Yancopoulos
STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(15):6915-9.
1995: M Rydén; Judith Murray-Rust; D Glass; Leodevico L Ilag; M Trupp; George D Yancopoulos; N Q McDonald; Carlos F Ibáñez
Functional analysis of mutant neurotrophins deficient in low-affinity binding reveals a role for p75LNGFR in NT-4 signalling.
The EMBO journal 1995;14(9):1979-90.
1995: David M Valenzuela; E Rojas; J A Griffiths; D L Compton; M Gisser; Nancy Y Ip; mitchell goldfarb; George D Yancopoulos
Identification of full-length and truncated forms of Ehk-3, a novel member of the Eph receptor tyrosine kinase family.
Oncogene 1995;10(8):1573-80.
1995: AL Acheson; J C Conover; J P Fandl; Thomas M DeChiara; M Russell; A Thadani; S P Squinto; George D Yancopoulos; RM Lindsay
A BDNF autocrine loop in adult sensory neurons prevents cell death.
Nature 1995;374(6521):450-3.
1995: Neil stahl; T J Farruggella; T G Boulton; Z Zhong; James E Darnell; George D Yancopoulos
Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors.
Science (New York, N.Y.) 1995;267(5202):1349-53.
1995: Leodevico L Ilag; Rory Curtis; D Glass; H Funakoshi; N J Tobkes; Terence Edward Ryan; AL Acheson; RM Lindsay; H Persson; George D Yancopoulos
Pan-neurotrophin 1: a genetically engineered neurotrophic factor displaying multiple specificities in peripheral neurons in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(2):607-11.
1995: Nancy Y Ip; George D Yancopoulos
Neurotrophic factors and their receptors.
Progress in brain research 1995;105():189-95.
1994: S Davis; nicholas gale; Thomas H Aldrich; Peter C Maisonpierre; V Lhotak; T Pawson; mitchell goldfarb; George D Yancopoulos
Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity.
Science (New York, N.Y.) 1994;266(5186):816-9.
1994: Neil stahl; George D Yancopoulos
The tripartite CNTF receptor complex: activation and signaling involves components shared with other cytokines.
Journal of neurobiology 1994;25(11):1454-66.
1994: Nancy Y Ip; T G Boulton; Y Li; J M Verdi; S J Birren; David J Anderson; George D Yancopoulos
CNTF, FGF, and NGF collaborate to drive the terminal differentiation of MAH cells into postmitotic neurons.
Neuron 1994;13(2):443-55.
1994: P A Hantzopoulos; Chitra Suri; David J Glass; mitchell goldfarb; George D Yancopoulos
The low affinity NGF receptor, p75, can collaborate with each of the Trks to potentiate functional responses to the neurotrophins.
Neuron 1994;13(1):187-201.
1994: John S Rudge; Y Li; E M Pasnikowski; K Mattsson; L Pan; George D Yancopoulos; Stanley J Wiegand; RM Lindsay; Nancy Y Ip
Neurotrophic factor receptors and their signal transduction capabilities in rat astrocytes.
The European journal of neuroscience 1994;6(5):693-705.
1994: J M Verdi; Nancy Y Ip; George D Yancopoulos; David J Anderson
Expression of trk in MAH cells lacking the p75 low-affinity nerve growth factor receptor is sufficient to permit nerve growth factor-induced differentiation to postmitotic neurons.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(9):3949-53.
1994: T G Boulton; Neil stahl; George D Yancopoulos
Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors.
The Journal of biological chemistry 1994;269(15):11648-55.
1994: M E Helgren; S P Squinto; H L Davis; D J Parry; T G Boulton; C S Heck; Y Zhu; George D Yancopoulos; RM Lindsay; PS DiStefano
Trophic effect of ciliary neurotrophic factor on denervated skeletal muscle.
Cell 1994;76(3):493-504.
1994: Neil stahl; T G Boulton; Nancy Y Ip; Samuel Davis; George D Yancopoulos
The tails of two proteins: the scrapie prion protein and the ciliary neurotrophic factor receptor.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1994;27(2):297-301.
1993: Peter C Maisonpierre; N X Barrezueta; George D Yancopoulos
Ehk-1 and Ehk-2: two novel members of the Eph receptor-like tyrosine kinase family with distinctive structures and neuronal expression.
Oncogene 1993;8(12):3277-88.
1993: J C Conover; Nancy Y Ip; W T Poueymirou; Brian Bates; mitchell goldfarb; Thomas M DeChiara; George D Yancopoulos
Ciliary neurotrophic factor maintains the pluripotentiality of embryonic stem cells.
Development (Cambridge, England) 1993;119(3):559-65.
1993: Neil stahl; George D Yancopoulos
The alphas, betas, and kinases of cytokine receptor complexes.
Cell 1993;74(4):587-90.
1993: David J Glass; George D Yancopoulos
The neurotrophins and their receptors.
Trends in cell biology 1993;3(8):262-8.
1993: Nancy Y Ip; Y Li; George D Yancopoulos; RM Lindsay
Cultured hippocampal neurons show responses to BDNF, NT-3, and NT-4, but not NGF.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993;13(8):3394-405.
1993: Samuel Davis; Thomas H Aldrich; Neil stahl; L Pan; T Taga; T Kishimoto; Nancy Y Ip; George D Yancopoulos
LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor.
Science (New York, N.Y.) 1993;260(5115):1805-8.
1993: Peter C Maisonpierre; mitchell goldfarb; George D Yancopoulos; G Gao
Distinct rat genes with related profiles of expression define a TIE receptor tyrosine kinase family.
Oncogene 1993;8(6):1631-7.
1993: David M Valenzuela; Peter C Maisonpierre; David J Glass; E Rojas; L Nuñez; Y Kong; D R Gies; Trevor N Stitt; Nancy Y Ip; George D Yancopoulos
Alternative forms of rat TrkC with different functional capabilities.
Neuron 1993;10(5):963-74.
1993: Neil stahl; S Davis; V Wong; Tetsuya Taga; Tadamitsu Kishimoto; N Y Ip; George D Yancopoulos
Cross-linking identifies leukemia inhibitory factor-binding protein as a ciliary neurotrophic factor receptor component.
The Journal of biological chemistry 1993;268(11):7628-31.
1993: Nancy Y Ip; Trevor N Stitt; P Tapley; R Klein; David J Glass; J Fandl; L A Greene; Mariano Barbacid; George D Yancopoulos
Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells.
Neuron 1993;10(2):137-49.
1993: Nancy Y Ip; Joyce McClain; N X Barrezueta; Thomas H Aldrich; L Pan; Y Li; Stanley J Wiegand; B Friedman; Samuel Davis; George D Yancopoulos
The alpha component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development.
Neuron 1993;10(1):89-102.
1992: Matthew M LaVail; Kazuhiko Unoki; Douglas Yasumura; Michael T Matthes; George D Yancopoulos; RH Steinberg
Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(23):11249-53.
1992: S H Nye; S P Squinto; David J Glass; Trevor N Stitt; P Hantzopoulos; M J Macchi; N S Lindsay; Nancy Y Ip; George D Yancopoulos
K-252a and staurosporine selectively block autophosphorylation of neurotrophin receptors and neurotrophin-mediated responses.
Molecular biology of the cell 1992;3(6):677-86.
1992: Peter C Maisonpierre; L Belluscio; J C Conover; George D Yancopoulos
Gene sequences of chicken BDNF and NT-3.
DNA sequence : the journal of DNA sequencing and mapping 1992;3(1):49-54.
1992: David J Glass; D R Gies; Trevor N Stitt; Samuel Davis; P Hantzopoulos; Nancy Y Ip; mitchell goldfarb; George D Yancopoulos
Cloning and analysis of neurotrophic factor receptors using function-based strategies.
Cold Spring Harbor symposia on quantitative biology 1992;57():53-62.
1992: Nancy Y Ip; George D Yancopoulos
Ciliary neurotrophic factor and its receptor complex.
Progress in growth factor research 1992;4(2):139-55.
1991: David J Glass; S H Nye; P Hantzopoulos; M J Macchi; S P Squinto; mitchell goldfarb; George D Yancopoulos
TrkB mediates BDNF/NT-3-dependent survival and proliferation in fibroblasts lacking the low affinity NGF receptor.
Cell 1991;66(2):405-13.
1991: R Seger; Natalie G Ahn; T G Boulton; George D Yancopoulos; N Panayotatos; E Radziejewska; L Ericsson; R L Bratlien; Melanie H Cobb; Edwin G Krebs
Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(14):6142-6.
1991: Samuel Davis; Thomas H Aldrich; David M Valenzuela; V V Wong; Mark E Furth; S P Squinto; George D Yancopoulos
The receptor for ciliary neurotrophic factor.
Science (New York, N.Y.) 1991;253(5015):59-63.
1991: Peter C Maisonpierre; M M Le Beau; R Espinosa; Nancy Y Ip; L Belluscio; Suzanne M de la Monte; S Squinto; Mark E Furth; George D Yancopoulos
Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations.
Genomics 1991;10(3):558-68.
1991: T G Boulton; S H Nye; David J. Robbins; Nancy Y Ip; E Radziejewska; S D Morgenbesser; Ronald A DePinho; N Panayotatos; Melanie H Cobb; George D Yancopoulos
ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF.
Cell 1991;65(4):663-75.
1991: C Hyman; M Hofer; Y A Barde; M Juhasz; George D Yancopoulos; S P Squinto; RM Lindsay
BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra.
Nature 1991;350(6315):230-2.
1991: RM Lindsay; Ralph Alderson; B Friedman; C Hyman; Nancy Y Ip; Mark E Furth; Peter C Maisonpierre; S P Squinto; George D Yancopoulos
The neurotrophin family of NGF-related neurotrophic factors.
Restorative neurology and neuroscience 1991;2(4):211-20.
1991: Nancy Y Ip; Peter C Maisonpierre; Ralph Alderson; B Friedman; Mark E Furth; N Panayotatos; S Squinto; George D Yancopoulos; RM Lindsay
The neurotrophins and CNTF: specificity of action towards PNS and CNS neurons.
Journal de physiologie 1991;85(3):123-30.
1990: S P Squinto; Thomas H Aldrich; RM Lindsay; D M Morrissey; N Panayotatos; S M Bianco; Mark E Furth; George D Yancopoulos
Identification of functional receptors for ciliary neurotrophic factor on neuronal cell lines and primary neurons.
Neuron 1990;5(6):757-66.
1990: Peter C Maisonpierre; L Belluscio; B Friedman; Ralph Alderson; Stanley J Wiegand; Mark E Furth; RM Lindsay; George D Yancopoulos
NT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression.
Neuron 1990;5(4):501-9.
1990: T G Boulton; George D Yancopoulos; J S Gregory; C Slaughter; Carolyn Moomaw; J Hsu; Melanie H Cobb
An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control.
Science (New York, N.Y.) 1990;249(4964):64-7.
1990: Peter C Maisonpierre; L Belluscio; S Squinto; Nancy Y Ip; Mark E Furth; RM Lindsay; George D Yancopoulos
Neurotrophin-3: a neurotrophic factor related to NGF and BDNF.
Science (New York, N.Y.) 1990;247(4949 Pt 1):1446-51.
1990: George D Yancopoulos; Peter C Maisonpierre; Nancy Y Ip; Thomas H Aldrich; L Belluscio; T G Boulton; M H Cobb; S P Squinto; Mark E Furth
Neurotrophic factors, their receptors, and the signal transduction pathways they activate.
Cold Spring Harbor symposia on quantitative biology 1990;55():371-9.