George Yancopoulos

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Torres R; Macdonald L; Croll S D; Reinhardt J; Dore A; Stevens S; Hylton D M; Rudge J S; Liu-Bryan R; Terkeltaub R A; Yancopoulos G D; Murphy A J
Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis.
Bhandarkar Sulochana S; Jaconi Marisa; Fried Levi E; Bonner Michael Y; Lefkove Benjamin; Govindarajan Baskaran; Perry Betsy N; Parhar Ravi; Mackelfresh Jamie; Sohn Allie; Stouffs Michael; Knaus Ulla; Yancopoulos George; Reiss Yvonne; Benest Andrew V; Augustin Hellmut G; Arbiser Jack L
Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice.
Hooper Andrea T; Shmelkov Sergey V; Gupta Sunny; Milde Till; Bambino Kathryn; Gillen Kelly; Goetz Mollie; Chavala Sai; Baljevic Muhamed; Murphy Andrew J; Valenzuela David M; Gale Nicholas W; Thurston Gavin; Yancopoulos George D; Vahdat Linda; Evans Todd; Rafii Shahin
Angiomodulin is a specific marker of vasculature and regulates vascular endothelial growth factor-A-dependent neoangiogenesis.

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2009: Torres R; Macdonald L; Croll S D; Reinhardt J; Dore A; Stevens S; Hylton D M; Rudge J S; Liu-Bryan R; Terkeltaub R A; Yancopoulos G D; Murphy A J
Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis.
Annals of the rheumatic diseases 2009;68(10):1602-8.
2009: Bhandarkar Sulochana S; Jaconi Marisa; Fried Levi E; Bonner Michael Y; Lefkove Benjamin; Govindarajan Baskaran; Perry Betsy N; Parhar Ravi; Mackelfresh Jamie; Sohn Allie; Stouffs Michael; Knaus Ulla; Yancopoulos George; Reiss Yvonne; Benest Andrew V; Augustin Hellmut G; Arbiser Jack L
Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice.
The Journal of clinical investigation 2009;119(8):2359-65.
2009: Hooper Andrea T; Shmelkov Sergey V; Gupta Sunny; Milde Till; Bambino Kathryn; Gillen Kelly; Goetz Mollie; Chavala Sai; Baljevic Muhamed; Murphy Andrew J; Valenzuela David M; Gale Nicholas W; Thurston Gavin; Yancopoulos George D; Vahdat Linda; Evans Todd; Rafii Shahin
Angiomodulin is a specific marker of vasculature and regulates vascular endothelial growth factor-A-dependent neoangiogenesis.
Circulation research 2009;105(2):201-8.
2009: Nair Meera G; Du Yurong; Perrigoue Jacqueline G; Zaph Colby; Taylor Justin J; Goldschmidt Michael; Swain Gary P; Yancopoulos George D; Valenzuela David M; Murphy Andrew; Karow Margaret; Stevens Sean; Pearce Edward J; Artis David
Alternatively activated macrophage-derived RELM-{alpha} is a negative regulator of type 2 inflammation in the lung.
The Journal of experimental medicine 2009;206(4):937-52.
2009: Crawford Laura A; Guney Michelle A; Oh Young Ah; Deyoung R Andrea; Valenzuela David M; Murphy Andrew J; Yancopoulos George D; Lyons Karen M; Brigstock David R; Economides Aris; Gannon Maureen
Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis.
Molecular endocrinology (Baltimore, Md.) 2009;23(3):324-36.
2009: Leppkes Moritz; Becker Christoph; Ivanov Ivaylo I; Hirth Sebastian; Wirtz Stefan; Neufert Clemens; Pouly Sandrine; Murphy Andrew J; Valenzuela David M; Yancopoulos George D; Becher Burkhard; Littman Dan R; Neurath Markus F
RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F.
Gastroenterology 2009;136(1):257-67.
2009: Dechiara Thomas M; Poueymirou William T; Auerbach Wojtek; Frendewey David; Yancopoulos George D; Valenzuela David M
VelociMouse: fully ES cell-derived F0-generation mice obtained from the injection of ES cells into eight-cell-stage embryos.
Methods in molecular biology (Clifton, N.J.) 2009;530():311-24.
2008: Nair Meera G; Guild Katherine J; Du Yurong; Zaph Colby; Yancopoulos George D; Valenzuela David M; Murphy Andrew; Stevens Sean; Karow Margaret; Artis David
Goblet cell-derived resistin-like molecule beta augments CD4+ T cell production of IFN-gamma and infection-induced intestinal inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(7):4709-15.
2008: Hoffman Hal M; Throne Martin L; Amar N J; Sebai Mohamed; Kivitz Alan J; Kavanaugh Arthur; Weinstein Steven P; Belomestnov Pavel; Yancopoulos George D; Stahl Neil; Mellis Scott J
Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies.
Arthritis and rheumatism 2008;58(8):2443-52.
2008: Long David A; Price Karen L; Ioffe Ella; Gannon Claire M; Gnudi Luigi; White Kathryn E; Yancopoulos George D; Rudge John S; Woolf Adrian S
Angiopoietin-1 therapy enhances fibrosis and inflammation following folic acid-induced acute renal injury.
Kidney international 2008;74(3):300-9.
2008: Shmelkov Sergey V; Butler Jason M; Hooper Andrea T; Hormigo Adilia; Kushner Jared; Milde Till; St Clair Ryan; Baljevic Muhamed; White Ian; Jin David K; Chadburn Amy; Murphy Andrew J; Valenzuela David M; Gale Nicholas W; Thurston Gavin; Yancopoulos George D; D'Angelica Michael; Kemeny Nancy; Lyden David; Rafii Shahin
CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors.
The Journal of clinical investigation 2008;118(6):2111-20.
2008: Raz Regina; Stricker Sigmar; Gazzerro Elizabetta; Clor Julie L; Witte Florian; Nistala Harakiran; Zabski Stefanie; Pereira Renata C; Stadmeyer Lisa; Wang Xiangmin; Gowen Lori; Sleeman Mark W; Yancopoulos George D; Canalis Ernesto; Mundlos Stefan; Valenzuela David M; Economides Aris N
The mutation ROR2W749X, linked to human BDB, is a recessive mutation in the mouse, causing brachydactyly, mediating patterning of joints and modeling recessive Robinow syndrome.
Development (Cambridge, England) 2008;135(9):1713-23.
2008: Lu Chunhua; Thaker Premal H; Lin Yvonne G; Spannuth Whitney; Landen Charles N; Merritt William M; Jennings Nicholas B; Langley Robert R; Gershenson David M; Yancopoulos George D; Ellis Lee M; Jaffe Robert B; Coleman Robert L; Sood Anil K
Impact of vessel maturation on antiangiogenic therapy in ovarian cancer.
American journal of obstetrics and gynecology 2008;198(4):477.e1-9; discussion 477.e9-10.
2008: Towne Charles F; York Ian A; Neijssen Joost; Karow Margaret L; Murphy Andrew J; Valenzuela David M; Yancopoulos George D; Neefjes Jacques J; Rock Kenneth L
Puromycin-sensitive aminopeptidase limits MHC class I presentation in dendritic cells but does not affect CD8 T cell responses during viral infections.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(3):1704-12.
2008: Kadenhe-Chiweshe Angela; Papa Joey; McCrudden Kimberly W; Frischer Jason; Bae Jae-O; Huang Jianzhong; Fisher Jason; Lefkowitch Jay H; Feirt Nikki; Rudge John; Holash Jocelyn; Yancopoulos George D; Kandel Jessica J; Yamashiro Darrell J
Sustained VEGF blockade results in microenvironmental sequestration of VEGF by tumors and persistent VEGF receptor-2 activation.
Molecular cancer research : MCR 2008;6(1):1-9.
2008: Ramalingam Thirumalai R; Pesce John T; Sheikh Faruk; Cheever Allen W; Mentink-Kane Margaret M; Wilson Mark S; Stevens Sean; Valenzuela David M; Murphy Andrew J; Yancopoulos George D; Urban Joseph F; Donnelly Raymond P; Wynn Thomas A
Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain.
Nature immunology 2008;9(1):25-33.
2007: Lombard David B; Alt Frederick W; Cheng Hwei-Ling; Bunkenborg Jakob; Streeper Ryan S; Mostoslavsky Raul; Kim Jennifer; Yancopoulos George; Valenzuela David; Murphy Andrew; Yang Yinhua; Chen Yaohui; Hirschey Matthew D; Bronson Roderick T; Haigis Marcia; Guarente Leonard P; Farese Robert V; Weissman Sherman; Verdin Eric; Schwer Bjoern
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.
Molecular and cellular biology 2007;27(24):8807-14.
2007: Rudge John S; Holash Jocelyn; Hylton Donna; Russell Michelle; Jiang Shelly; Leidich Raymond; Papadopoulos Nicholas; Pyles Erica A; Torri Al; Wiegand Stanley J; Thurston Gavin; Stahl Neil; Yancopoulos George D
Inaugural Article: VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(47):18363-70.
2007: Wortley Katherine E; Garcia Karen; Okamoto Haruka; Thabet Karen; Anderson Keith D; Shen Victor; Herman Jim P; Valenzuela David; Yancopoulos George D; Tschöp Matthias H; Murphy Andrew; Sleeman Mark W
Peptide YY regulates bone turnover in rodents.
Gastroenterology 2007;133(5):1534-43.
2007: Zenewicz Lauren A; Yancopoulos George D; Valenzuela David M; Murphy Andrew J; Karow Margaret; Flavell Richard A
Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation.
Immunity 2007;27(4):647-59.
2007: Todorovic Vesna; Frendewey David; Gutstein David E; Chen Yan; Freyer Laina; Finnegan Erin; Liu Fangyu; Murphy Andrew; Valenzuela David; Yancopoulos George; Rifkin Daniel B
Long form of latent TGF-beta binding protein 1 (Ltbp1L) is essential for cardiac outflow tract septation and remodeling.
Development (Cambridge, England) 2007;134(20):3723-32.
2007: Seandel Marco; James Daylon; Shmelkov Sergey V; Falciatori Ilaria; Kim Jiyeon; Chavala Sai; Scherr Douglas S; Zhang Fan; Torres Richard; Gale Nicholas W; Yancopoulos George D; Murphy Andrew; Valenzuela David M; Hobbs Robin M; Pandolfi Pier Paolo; Rafii Shahin
Generation of functional multipotent adult stem cells from GPR125+ germline progenitors.
Nature 2007;449(7160):346-50.
2007: Torres Richard; Croll Susan D; Vercollone Jeffrey; Reinhardt Joel; Griffiths Jennifer; Zabski Stephanie; Anderson Keith D; Adams Niels C; Gowen Lori; Sleeman Mark W; Valenzuela David M; Wiegand Stanley J; Yancopoulos George D; Murphy Andrew J
Mice genetically deficient in neuromedin U receptor 2, but not neuromedin U receptor 1, have impaired nociceptive responses.
Pain 2007;130(3):267-78.
2007: Verheul Henk M W; Hammers Hans; van Erp Karen; Wei Yonfeng; Sanni Tolib; Salumbides Brenda; Qian David Z; Yancopoulos George D; Pili Roberto
Vascular endothelial growth factor trap blocks tumor growth, metastasis formation, and vascular leakage in an orthotopic murine renal cell cancer model.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(14):4201-8.
2007: Thurston Gavin; Noguera-Troise Irene; Yancopoulos George D
The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth.
Nature reviews. Cancer 2007;7(5):327-31.
2007: Okamoto Haruka; Latres Esther; Liu Rong; Thabet Karen; Murphy Andrew; Valenzeula David; Yancopoulos George D; Stitt Trevor N; Glass David J; Sleeman Mark W
Genetic deletion of Trb3, the mammalian Drosophila tribbles homolog, displays normal hepatic insulin signaling and glucose homeostasis.
Diabetes 2007;56(5):1350-6.
2007: Shimoda Hiroshi; Bernas Michael J; Witte Marlys H; Gale Nicholas W; Yancopoulos George D; Kato Seiji
Abnormal recruitment of periendothelial cells to lymphatic capillaries in digestive organs of angiopoietin-2-deficient mice.
Cell and tissue research 2007;328(2):329-37.
2007: Thai To-Ha; Calado Dinis Pedro; Casola Stefano; Ansel K Mark; Xiao Changchun; Xue Yingzi; Murphy Andrew; Frendewey David; Valenzuela David; Kutok Jeffery L; Schmidt-Supprian Marc; Rajewsky Nikolaus; Yancopoulos George; Rao Anjana; Rajewsky Klaus
Regulation of the germinal center response by microRNA-155.
Science (New York, N.Y.) 2007;316(5824):604-8.
2007: Wachsberger Phyllis R; Burd Randy; Cardi Chris; Thakur Mathew; Daskalakis Constantine; Holash Jocelyn; Yancopoulos George D; Dicker Adam P
VEGF trap in combination with radiotherapy improves tumor control in u87 glioblastoma.
International journal of radiation oncology, biology, physics 2007;67(5):1526-37.
2007: Dominguez Melissa G; Hughes Virginia C; Pan Li; Simmons Mary; Daly Christopher; Anderson Keith; Noguera-Troise Irene; Murphy Andrew J; Valenzuela David M; Davis Samuel; Thurston Gavin; Yancopoulos George D; Gale Nicholas W
Vascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3243-8.
2007: Lobov I B; Renard R A; Papadopoulos N; Gale N W; Thurston G; Yancopoulos G D; Wiegand S J
Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3219-24.
2007: Poueymirou William T; Auerbach Wojtek; Frendewey David; Hickey Joseph F; Escaravage Jennifer M; Esau Lakeisha; Doré Anthony T; Stevens Sean; Adams Niels C; Dominguez Melissa G; Gale Nicholas W; Yancopoulos George D; DeChiara Thomas M; Valenzuela David M
F0 generation mice fully derived from gene-targeted embryonic stem cells allowing immediate phenotypic analyses.
Nature biotechnology 2007;25(1):91-9.
2007: Gale Nicholas W; Prevo Remko; Espinosa Jorge; Ferguson David J; Dominguez Melissa G; Yancopoulos George D; Thurston Gavin; Jackson David G
Normal lymphatic development and function in mice deficient for the lymphatic hyaluronan receptor LYVE-1.
Molecular and cellular biology 2007;27(2):595-604.
2007: Noguera-Troise Irene; Daly Christopher; Papadopoulos Nicholas J; Coetzee Sandra; Boland Pat; Gale Nicholas W; Lin Hsin Chieh; Yancopoulos George D; Thurston Gavin
Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis.
Novartis Foundation symposium 2007;283():106-20; discussion 121-5, 238-41.
2007: Kasselman Lora J; Kintner Jennifer; Sideris Alexandra; Pasnikowski Elizabeth; Krellman Jason W; Shah Sagar; Rudge John S; Yancopoulos George D; Wiegand Stanley J; Croll Susan D
Dexamethasone treatment and ICAM-1 deficiency impair VEGF-induced angiogenesis in adult brain.
Journal of vascular research 2007;44(4):283-91.
2006: Noguera-Troise Irene; Daly Christopher; Papadopoulos Nicholas J; Coetzee Sandra; Boland Pat; Gale Nicholas W; Lin Hsin Chieh; Yancopoulos George D; Thurston Gavin
Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis.
Nature 2006;444(7122):1032-7.
2006: Daly Christopher; Pasnikowski Elizabeth; Burova Elena; Wong Vivian; Aldrich Thomas H; Griffiths Jennifer; Ioffe Ella; Daly Thomas J; Fandl James P; Papadopoulos Nick; McDonald Donald M; Thurston Gavin; Yancopoulos George D; Rudge John S
Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(42):15491-6.
2006: Perry Betsy N; Govindarajan Baskaran; Bhandarkar Sulochana S; Knaus Ulla G; Valo Monika; Sturk Celina; Carrillo Carol O; Sohn Allie; Cerimele Francesca; Dumont Dan; Losken Albert; Williams Joseph; Brown Lawrence F; Tan Xiaolian; Ioffe Ella; Yancopoulos George D; Arbiser Jack L
Pharmacologic blockade of angiopoietin-2 is efficacious against model hemangiomas in mice.
The Journal of investigative dermatology 2006;126(10):2316-22.
2006: Haigis Marcia C; Mostoslavsky Raul; Haigis Kevin M; Fahie Kamau; Christodoulou Danos C; Murphy Andrew J; Valenzuela David M; Yancopoulos George D; Karow Margaret; Blander Gil; Wolberger Cynthia; Prolla Tomas A; Weindruch Richard; Alt Frederick W; Guarente Leonard
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.
Cell 2006;126(5):941-54.
2006: Becker Christoph; Dornhoff Heike; Neufert Clemens; Fantini Massimo C; Wirtz Stefan; Huebner Sabine; Nikolaev Alexei; Lehr Hans-Anton; Murphy Andrew J; Valenzuela David M; Yancopoulos George D; Galle Peter R; Karow Margaret; Neurath Markus F
Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(5):2760-4.
2006: Hogan Simon P; Seidu Luqman; Blanchard Carine; Groschwitz Katherine; Mishra Anil; Karow Margaret L; Ahrens Richard; Artis David; Murphy Andrew J; Valenzuela David M; Yancopoulos George D; Rothenberg Marc E
Resistin-like molecule beta regulates innate colonic function: barrier integrity and inflammation susceptibility.
The Journal of allergy and clinical immunology 2006;118(1):257-68.
2006: Tam Betty Y Y; Wei Kevin; Rudge John S; Hoffman Jana; Holash Joceyln; Park Sang-ki; Yuan Jenny; Hefner Colleen; Chartier Cecile; Lee Jeng-Shin; Jiang Shelly; Nayak Nihar R; Kuypers Frans A; Ma Lisa; Sundram Uma; Wu Grace; Garcia Joseph A; Schrier Stanley L; Maher Jacquelyn J; Johnson Randall S; Yancopoulos George D; Mulligan Richard C; Kuo Calvin J
VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis.
Nature medicine 2006;12(7):793-800.
2006: Holash Jocelyn; Thurston Gavin; Rudge John S; Yancopoulos George D; Adjei Alex A; Bergers Gabriele; Pytowski Bronislaw; Pegram Mark; Gordon Michael S
Inhibitors of growth factor receptors, signaling pathways and angiogenesis as therapeutic molecular agents.
Cancer metastasis reviews 2006;25(2):243-52.
2006: Amici Stephanie A; Dunn William A; Murphy Andrew J; Adams Niels C; Gale Nicholas W; Valenzuela David M; Yancopoulos George D; Notterpek Lucia
Peripheral myelin protein 22 is in complex with alpha6beta4 integrin, and its absence alters the Schwann cell basal lamina.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(4):1179-89.
2005: Wortley Katherine E; Anderson Keith D; Yasenchak Jason; Murphy Andrew; Valenzuela David; Diano Sabrina; Yancopoulos George D; Wiegand Stanley J; Sleeman Mark W
Agouti-related protein-deficient mice display an age-related lean phenotype.
Cell metabolism 2005;2(6):421-7.
2005: Towne Charles F; York Ian A; Neijssen Joost; Karow Margaret L; Murphy Andrew J; Valenzuela David M; Yancopoulos George D; Neefjes Jacques J; Rock Kenneth L
Leucine aminopeptidase is not essential for trimming peptides in the cytosol or generating epitopes for MHC class I antigen presentation.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(10):6605-14.
2005: Hu Limin; Hofmann Judith; Holash Jocelyn; Yancopoulos George D; Sood Anil K; Jaffe Robert B
Vascular endothelial growth factor trap combined with paclitaxel strikingly inhibits tumor and ascites, prolonging survival in a human ovarian cancer model.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(19 Pt 1):6966-71.
2005: Thurston Gavin; Wang Quan; Baffert Fabienne; Rudge John; Papadopoulos Nicholas; Jean-Guillaume Danielle; Wiegand Stanley; Yancopoulos George D; McDonald Donald M
Angiopoietin 1 causes vessel enlargement, without angiogenic sprouting, during a critical developmental period.
Development (Cambridge, England) 2005;132(14):3317-26.
2005: Oshima Yuji; Oshima Sachiko; Nambu Hiroyuki; Kachi Shu; Takahashi Kyoichi; Umeda Naoyasu; Shen JiKui; Dong Aling; Apte Rajendra S; Duh Elia; Hackett Sean F; Okoye Godwin; Ishibashi Kazuki; Handa James; Melia Michele; Wiegand Stanley; Yancopoulos George; Zack Donald J; Campochiaro Peter A
Different effects of angiopoietin-2 in different vascular beds: new vessels are most sensitive.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(8):963-5.
2005: Choi Gloria B; Dong Hong-Wei; Murphy Andrew J; Valenzuela David M; Yancopoulos George D; Swanson Larry W; Anderson David J
Lhx6 delineates a pathway mediating innate reproductive behaviors from the amygdala to the hypothalamus.
Neuron 2005;46(4):647-60.
2005: Kasus-Jacobi Anne; Ou Jiafu; Birch David G; Locke Kirsten G; Shelton John M; Richardson James A; Murphy Andrew J; Valenzuela David M; Yancopoulos George D; Edwards Albert O
Functional characterization of mouse RDH11 as a retinol dehydrogenase involved in dark adaptation in vivo.
The Journal of biological chemistry 2005;280(21):20413-20.
2005: Macdonald Lynn E; Wortley Katherine E; Gowen Lori C; Anderson Keith D; Murray Jane D; Poueymirou William T; Simmons Mary V; Barber Dianna; Valenzuela David M; Economides Aris N; Wiegand Stanley J; Yancopoulos George D; Sleeman Mark W; Murphy Andrew J
Resistance to diet-induced obesity in mice globally overexpressing OGH/GPB5.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(7):2496-501.
2005: Sleeman Mark W; Wortley Katherine E; Lai Ka-Man V; Gowen Lori C; Kintner Jennifer; Kline William O; Garcia Karen; Stitt Trevor N; Yancopoulos George D; Wiegand Stanley J; Glass David J
Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity.
Nature medicine 2005;11(2):199-205.
2005: Latres Esther; Amini Ami R; Amini Ashley A; Griffiths Jennifer; Martin Francis J; Wei Yi; Lin Hsin Chieh; Yancopoulos George D; Glass David J
Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway.
The Journal of biological chemistry 2005;280(4):2737-44.
2005: Thurston Gavin; Rudge John S; Ioffe Ella; Papadopoulos Nicholas; Daly Christopher; Vuthoori Srilatha; Daly Thomas; Wiegand Stanley J; Yancopoulos George D
The anti-inflammatory actions of angiopoietin-1.
EXS 2005;(94):233-45.
2004: Pitera Jolanta E; Woolf Adrian S; Gale Nicholas W; Yancopoulos George D; Yuan Hai Tao
Dysmorphogenesis of kidney cortical peritubular capillaries in angiopoietin-2-deficient mice.
The American journal of pathology 2004;165(6):1895-906.
2004: Gale Nicholas W; Dominguez Melissa G; Noguera Irene; Pan Li; Hughes Virginia; Valenzuela David M; Murphy Andrew J; Adams Niels C; Lin Hsin Chieh; Holash Jocelyn; Thurston Gavin; Yancopoulos George D
Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(45):15949-54.
2004: Lai Ka-Man V; Gonzalez Michael; Poueymirou William T; Kline William O; Na Erqian; Zlotchenko Elizabeth; Stitt Trevor N; Economides Aris N; Yancopoulos George D; Glass David J
Conditional activation of akt in adult skeletal muscle induces rapid hypertrophy.
Molecular and cellular biology 2004;24(21):9295-304.
2004: Frischer Jason S; Huang Jianzhong; Serur Anna; Kadenhe-Chiweshe Angela; McCrudden Kimberly W; O'Toole Kathleen; Holash Jocelyn; Yancopoulos George D; Yamashiro Darrell J; Kandel Jessica J
Effects of potent VEGF blockade on experimental Wilms tumor and its persisting vasculature.
International journal of oncology 2004;25(3):549-53.
2004: Zhou Yi Fu; Stabile Eugenio; Walker Jill; Shou Matie; Baffour Richard; Yu Zuxi; Rott David; Yancopoulos George D; Rudge John S; Epstein Stephen E
Effects of gene delivery on collateral development in chronic hypoperfusion: diverse effects of angiopoietin-1 versus vascular endothelial growth factor.
Journal of the American College of Cardiology 2004;44(4):897-903.
2004: Inai Tetsuichiro; Mancuso Michael; Hashizume Hiroya; Baffert Fabienne; Haskell Amy; Baluk Peter; Hu-Lowe Dana D; Shalinsky David R; Thurston Gavin; Yancopoulos George D; McDonald Donald M
Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts.
The American journal of pathology 2004;165(1):35-52.
2004: Croll Susan D; Ransohoff Richard M; Cai Ning; Zhang Qing; Martin Francis J; Wei Tao; Kasselman Lora J; Kintner Jennifer; Murphy Andrew J; Yancopoulos George D; Wiegand Stanley J
VEGF-mediated inflammation precedes angiogenesis in adult brain.
Experimental neurology 2004;187(2):388-402.
2004: Wortley Katherine E; Anderson Keith D; Garcia Karen; Murray Jane D; Malinova Lubomira; Liu Rong; Moncrieffe Marshena; Thabet Karen; Cox Hilary J; Yancopoulos George D; Wiegand Stanley J; Sleeman Mark W
Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(21):8227-32.
2004: Daly Christopher; Wong Vivian; Burova Elena; Wei Yi; Zabski Stephanie; Griffiths Jennifer; Lai Ka-Man; Lin Hsin Chieh; Ioffe Ella; Yancopoulos George D; Rudge John S
Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1).
Genes & development 2004;18(9):1060-71.
2004: Stitt Trevor N; Drujan Doreen; Clarke Brian A; Panaro Frank; Timofeyva Yekatarina; Kline William O; Gonzalez Michael; Yancopoulos George D; Glass David J
The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors.
Molecular cell 2004;14(3):395-403.
2004: Nambu H; Nambu R; Oshima Y; Hackett S F; Okoye G; Wiegand S; Yancopoulos G; Zack D J; Campochiaro P A
Angiopoietin 1 inhibits ocular neovascularization and breakdown of the blood-retinal barrier.
Gene therapy 2004;11(10):865-73.
2004: Huang Jianzhong; Frischer Jason S; New Tamara; Kim Eugene S; Serur Anna; Lee Alice; Kadenhe-Chiwishe Angela; Pollyea Daniel A; Yokoi Akiko; Holash Jocelyn; Yancopoulos George D; Kandel Jessica J; Yamashiro Darrell J
TNP-470 promotes initial vascular sprouting in xenograft tumors.
Molecular cancer therapeutics 2004;3(3):335-43.
2004: Feldheim David A; Nakamoto Masaru; Osterfield Miriam; Gale Nicholas W; DeChiara Thomas M; Rohatgi Rajat; Yancopoulos George D; Flanagan John G
Loss-of-function analysis of EphA receptors in retinotectal mapping.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(10):2542-50.
2004: Saucier Caroline; Khoury Hanane; Lai Ka-Man Venus; Peschard Pascal; Dankort David; Naujokas Monica A; Holash Jocelyn; Yancopoulos George D; Muller William J; Pawson Tony; Park Morag
The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(8):2345-50.
2003: Byrne Annette T; Ross Leorah; Holash Joceyln; Nakanishi Mikiye; Hu Limin; Hofmann Judith I; Yancopoulos George D; Jaffe Robert B
Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(15):5721-8.
2003: Sleeman M W; Garcia K; Liu R; Murray J D; Malinova L; Moncrieffe M; Yancopoulos G D; Wiegand S J
Ciliary neurotrophic factor improves diabetic parameters and hepatic steatosis and increases basal metabolic rate in db/db mice.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):14297-302.
2003: Harfouche Rania; Gratton Jean-Philippe; Yancopoulos George D; Noseda Michela; Karsan Aly; Hussain Sabah N A
Angiopoietin-1 activates both anti- and proapoptotic mitogen-activated protein kinases.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(11):1523-5.
2003: Anderson K D; Lambert P D; Corcoran T L; Murray J D; Thabet K E; Yancopoulos G D; Wiegand S J
Activation of the hypothalamic arcuate nucleus predicts the anorectic actions of ciliary neurotrophic factor and leptin in intact and gold thioglucose-lesioned mice.
Journal of neuroendocrinology 2003;15(7):649-60.
2003: Xia Yu-Ping; Li Baosheng; Hylton Donna; Detmar Michael; Yancopoulos George D; Rudge John S
Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasis.
Blood 2003;102(1):161-8.
2003: Huang Jianzhong; Frischer Jason S; Serur Anna; Kadenhe Angela; Yokoi Akiko; McCrudden Kimberly W; New Tamara; O'Toole Kathleen; Zabski Stephanie; Rudge John S; Holash Jocelyn; Yancopoulos George D; Yamashiro Darrell J; Kandel Jessica J
Regression of established tumors and metastases by potent vascular endothelial growth factor blockade.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(13):7785-90.
2003: Larcher Fernando; Franco Marcela; Bolontrade Marcela; Rodriguez-Puebla Marcelo; Casanova Llanos; Navarro Manuel; Yancopoulos George; Jorcano José L; Conti Claudio J
Modulation of the angiogenesis response through Ha-ras control, placenta growth factor, and angiopoietin expression in mouse skin carcinogenesis.
Molecular carcinogenesis 2003;37(2):83-90.
2003: Valenzuela David M; Murphy Andrew J; Frendewey David; Gale Nicholas W; Economides Aris N; Auerbach Wojtek; Poueymirou William T; Adams Niels C; Rojas Jose; Yasenchak Jason; Chernomorsky Rostislav; Boucher Marylene; Elsasser Andrea L; Esau Lakeisha; Zheng Jenny; Griffiths Jennifer A; Wang Xiaorong; Su Hong; Xue Yingzi; Dominguez Melissa G; Noguera Irene; Torres Richard; Macdonald Lynn E; Stewart A Francis; DeChiara Thomas M; Yancopoulos George D
High-throughput engineering of the mouse genome coupled with high-resolution expression analysis.
Nature biotechnology 2003;21(6):652-9.
2003: Ongusaha Pat P; Kim Jong-il; Fang Li; Wong Tai W; Yancopoulos George D; Aaronson Stuart A; Lee Sam W
p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop.
The EMBO journal 2003;22(6):1289-301.
2003: Joussen Antonia M; Poulaki Vassiliki; Mitsiades Nicholas; Stechschulte Stephen U; Kirchhof Bernd; Dartt Darlene A; Fong Guo-Hua; Rudge John; Wiegand Stanley J; Yancopoulos George D; Adamis Anthony P
VEGF-dependent conjunctivalization of the corneal surface.
Investigative ophthalmology & visual science 2003;44(1):117-23.
2003: Economides Aris N; Carpenter Laura Rocco; Rudge John S; Wong Vivien; Koehler-Stec Ellen M; Hartnett Christopher; Pyles Erica A; Xu Xiaobing; Daly Thomas J; Young Michael R; Fandl James P; Lee Frank; Carver Scott; McNay Jennifer; Bailey Kevin; Ramakanth Swayampakula; Hutabarat Renta; Huang Tammy T; Radziejewski Czeslaw; Yancopoulos George D; Stahl Neil
Cytokine traps: multi-component, high-affinity blockers of cytokine action.
Nature medicine 2003;9(1):47-52.
2003: Davis Samuel; Papadopoulos Nick; Aldrich Thomas H; Maisonpierre Peter C; Huang Tammy; Kovac Lubomir; Xu April; Leidich Raymond; Radziejewska Elzbieta; Rafique Ashique; Goldberg Judah; Jain Vivek; Bailey Kevin; Karow Margaret; Fandl Jim; Samuelsson Steven J; Ioffe Ella; Rudge John S; Daly Thomas J; Radziejewski Czeslaw; Yancopoulos George D
Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering.
Nature structural biology 2003;10(1):38-44.
2002: Uemura Akiyoshi; Ogawa Minetaro; Hirashima Masanori; Fujiwara Takashi; Koyama Shinji; Takagi Hitoshi; Honda Yoshihito; Wiegand Stanley J; Yancopoulos George D; Nishikawa Shin-Ichi
Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells.
The Journal of clinical investigation 2002;110(11):1619-28.
2002: Cheng Nikki; Brantley Dana M; Liu Hua; Lin Qin; Enriquez Miriam; Gale Nick; Yancopoulos George; Cerretti Douglas Pat; Daniel Thomas O; Chen Jin
Blockade of EphA receptor tyrosine kinase activation inhibits vascular endothelial cell growth factor-induced angiogenesis.
Molecular cancer research : MCR 2002;1(1):2-11.
2002: Gale Nicholas W; Thurston Gavin; Hackett Sean F; Renard Roumiana; Wang Quan; McClain Joyce; Martin Cliff; Witte Charles; Witte Marlys H; Jackson David; Suri Chitra; Campochiaro Peter A; Wiegand Stanley J; Yancopoulos George D
Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1.
Developmental cell 2002;3(3):411-23.
2002: Kim Eugene S; Serur Anna; Huang Jianzhong; Manley Christina A; McCrudden Kimberly W; Frischer Jason S; Soffer Samuel Z; Ring Laurence; New Tamara; Zabski Stephanie; Rudge John S; Holash Jocelyn; Yancopoulos George D; Kandel Jessica J; Yamashiro Darrell J
Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11399-404.
2002: Holash Jocelyn; Davis Sam; Papadopoulos Nick; Croll Susan D; Ho Lillian; Russell Michelle; Boland Patricia; Leidich Ray; Hylton Donna; Burova Elena; Ioffe Ella; Huang Tammy; Radziejewski Czeslaw; Bailey Kevin; Fandl James P; Daly Tom; Wiegand Stanley J; Yancopoulos George D; Rudge John S
VEGF-Trap: a VEGF blocker with potent antitumor effects.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11393-8.
2002: Yue Yong; Chen Zhi-Yong; Gale Nick W; Blair-Flynn Jan; Hu Tian-Jing; Yue Xin; Cooper Margaret; Crockett David P; Yancopoulos George D; Tessarollo Lino; Zhou Renping
Mistargeting hippocampal axons by expression of a truncated Eph receptor.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10777-82.
2002: Hackett Sean F; Wiegand Stanley; Yancopoulos George; Campochiaro Peter A
Angiopoietin-2 plays an important role in retinal angiogenesis.
Journal of cellular physiology 2002;192(2):182-7.
2002: Harfouche Rania; Hasséssian Haroutioun M; Guo Yang; Faivre Valérie; Srikant Coimbatore B; Yancopoulos George D; Hussain Sabah N A
Mechanisms which mediate the antiapoptotic effects of angiopoietin-1 on endothelial cells.
Microvascular research 2002;64(1):135-47.
2002: Kim Injune; Ryu Young Shin; Kwak Hee Jin; Ahn So Young; Oh Jong-Lark; Yancopoulos George D; Gale Nicholas W; Koh Gou Young
EphB ligand, ephrinB2, suppresses the VEGF- and angiopoietin 1-induced Ras/mitogen-activated protein kinase pathway in venous endothelial cells.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(9):1126-8.
2002: Joussen Antonia M; Poulaki Vassiliki; Tsujikawa Akitaka; Qin Wenying; Qaum Tamim; Xu Qingwen; Moromizato Yasufumi; Bursell Sven-Erik; Wiegand Stanley J; Rudge John; Ioffe Ella; Yancopoulos George D; Adamis Anthony P
Suppression of diabetic retinopathy with angiopoietin-1.
The American journal of pathology 2002;160(5):1683-93.
2002: Ikeda Kazuo; Wang Li-Hsien; Torres Richard; Zhao Hong; Olaso Elvira; Eng Francis J; Labrador Pablo; Klein Rudiger; Lovett David; Yancopoulos George D; Friedman Scott L; Lin Hsin Chieh
Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen.
The Journal of biological chemistry 2002;277(21):19206-12.
2002: Poulaki Vassiliki; Qin Wenying; Joussen Antonia M; Hurlbut Peter; Wiegand Stanley J; Rudge John; Yancopoulos George D; Adamis Anthony P
Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1alpha and VEGF.
The Journal of clinical investigation 2002;109(6):805-15.
2002: Joussen Antonia M; Poulaki Vassiliki; Qin Wenying; Kirchhof Bernd; Mitsiades Nicholas; Wiegand Stanley J; Rudge John; Yancopoulos George D; Adamis Anthony P
Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo.
The American journal of pathology 2002;160(2):501-9.
2002: Gale N W; Thurston G; Davis S; Wiegand S J; Holash J; Rudge J S; Yancopoulos G D
Complementary and coordinated roles of the VEGFs and angiopoietins during normal and pathologic vascular formation.
Cold Spring Harbor symposia on quantitative biology 2002;67():267-73.
2001: Bodine S C; Stitt T N; Gonzalez M; Kline W O; Stover G L; Bauerlein R; Zlotchenko E; Scrimgeour A; Lawrence J C; Glass D J; Yancopoulos G D
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo.
Nature cell biology 2001;3(11):1014-9.
2001: Rommel C; Bodine S C; Clarke B A; Rossman R; Nunez L; Stitt T N; Yancopoulos G D; Glass D J
Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways.
Nature cell biology 2001;3(11):1009-13.
2001: Bodine S C; Latres E; Baumhueter S; Lai V K; Nunez L; Clarke B A; Poueymirou W T; Panaro F J; Na E; Dharmarajan K; Pan Z Q; Valenzuela D M; DeChiara T M; Stitt T N; Yancopoulos G D; Glass D J
Identification of ubiquitin ligases required for skeletal muscle atrophy.
Science (New York, N.Y.) 2001;294(5547):1704-8.
2001: Qaum T; Xu Q; Joussen A M; Clemens M W; Qin W; Miyamoto K; Hassessian H; Wiegand S J; Rudge J; Yancopoulos G D; Adamis A P
VEGF-initiated blood-retinal barrier breakdown in early diabetes.
Investigative ophthalmology & visual science 2001;42(10):2408-13.
2001: Labrador J P; Azcoitia V; Tuckermann J; Lin C; Olaso E; Mañes S; Brückner K; Goergen J L; Lemke G; Yancopoulos G; Angel P; Martínez C; Klein R
The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism.
EMBO reports 2001;2(5):446-52.
2001: Terrado J; Burgess R W; DeChiara T; Yancopoulos G; Sanes J R; Kato A C
Motoneuron survival is enhanced in the absence of neuromuscular junction formation in embryos.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(9):3144-50.
2001: Kullander K; Croll S D; Zimmer M; Pan L; McClain J; Hughes V; Zabski S; DeChiara T M; Klein R; Yancopoulos G D; Gale N W
Ephrin-B3 is the midline barrier that prevents corticospinal tract axons from recrossing, allowing for unilateral motor control.
Genes & development 2001;15(7):877-88.
2001: Lambert P D; Anderson K D; Sleeman M W; Wong V; Tan J; Hijarunguru A; Corcoran T L; Murray J D; Thabet K E; Yancopoulos G D; Wiegand S J
Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(8):4652-7.
2001: Gale N W; Baluk P; Pan L; Kwan M; Holash J; DeChiara T M; McDonald D M; Yancopoulos G D
Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells.
Developmental biology 2001;230(2):151-60.
2000: Yancopoulos G D; Davis S; Gale N W; Rudge J S; Wiegand S J; Holash J
Vascular-specific growth factors and blood vessel formation.
Nature 2000;407(6801):242-8.
2000: Hackett S F; Ozaki H; Strauss R W; Wahlin K; Suri C; Maisonpierre P; Yancopoulos G; Campochiaro P A
Angiopoietin 2 expression in the retina: upregulation during physiologic and pathologic neovascularization.
Journal of cellular physiology 2000;184(3):275-84.
2000: Zagzag D; Friedlander D R; Margolis B; Grumet M; Semenza G L; Zhong H; Simons J W; Holash J; Wiegand S J; Yancopoulos G D
Molecular events implicated in brain tumor angiogenesis and invasion.
Pediatric neurosurgery 2000;33(1):49-55.
2000: Zagzag D; Amirnovin R; Greco M A; Yee H; Holash J; Wiegand S J; Zabski S; Yancopoulos G D; Grumet M
Vascular apoptosis and involution in gliomas precede neovascularization: a novel concept for glioma growth and angiogenesis.
Laboratory investigation; a journal of technical methods and pathology 2000;80(6):837-49.
2000: Yuan H T; Suri C; Landon D N; Yancopoulos G D; Woolf A S
Angiopoietin-2 is a site-specific factor in differentiation of mouse renal vasculature.
Journal of the American Society of Nephrology : JASN 2000;11(6):1055-66.
2000: Marcus R C; Matthews G A; Gale N W; Yancopoulos G D; Mason C A
Axon guidance in the mouse optic chiasm: retinal neurite inhibition by ephrin "A"-expressing hypothalamic cells in vitro.
Developmental biology 2000;221(1):132-47.
2000: Thurston G; Rudge J S; Ioffe E; Zhou H; Ross L; Croll S D; Glazer N; Holash J; McDonald D M; Yancopoulos G D
Angiopoietin-1 protects the adult vasculature against plasma leakage.
Nature medicine 2000;6(4):460-3.
2000: Sleeman M W; Anderson K D; Lambert P D; Yancopoulos G D; Wiegand S J
The ciliary neurotrophic factor and its receptor, CNTFR alpha.
Pharmaceutica acta Helvetiae 2000;74(2-3):265-72.
2000: Oldridge M; Fortuna A M; Maringa M; Propping P; Mansour S; Pollitt C; DeChiara T M; Kimble R B; Valenzuela D M; Yancopoulos G D; Wilkie A O
Dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B.
Nature genetics 2000;24(3):275-8.
2000: DeChiara T M; Kimble R B; Poueymirou W T; Rojas J; Masiakowski P; Valenzuela D M; Yancopoulos G D
Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development.
Nature genetics 2000;24(3):271-4.
1999: Thurston G; Suri C; Smith K; McClain J; Sato T N; Yancopoulos G D; McDonald D M
Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1.
Science (New York, N.Y.) 1999;286(5449):2511-4.
1999: Rommel C; Clarke B A; Zimmermann S; Nuñez L; Rossman R; Reid K; Moelling K; Yancopoulos G D; Glass D J
Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.
Science (New York, N.Y.) 1999;286(5445):1738-41.
1999: Zagzag D; Hooper A; Friedlander D R; Chan W; Holash J; Wiegand S J; Yancopoulos G D; Grumet M
In situ expression of angiopoietins in astrocytomas identifies angiopoietin-2 as an early marker of tumor angiogenesis.
Experimental neurology 1999;159(2):391-400.
1999: Holash J; Wiegand S J; Yancopoulos G D
New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF.
Oncogene 1999;18(38):5356-62.
1999: Yuan H T; Suri C; Yancopoulos G D; Woolf A S
Expression of angiopoietin-1, angiopoietin-2, and the Tie-2 receptor tyrosine kinase during mouse kidney maturation.
Journal of the American Society of Nephrology : JASN 1999;10(8):1722-36.
1999: Holash J; Maisonpierre P C; Compton D; Boland P; Alexander C R; Zagzag D; Yancopoulos G D; Wiegand S J
Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF.
Science (New York, N.Y.) 1999;284(5422):1994-8.
1999: Gale N W; Yancopoulos G D
Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development.
Genes & development 1999;13(9):1055-66.
1999: Gautam M; DeChiara T M; Glass D J; Yancopoulos G D; Sanes J R
Distinct phenotypes of mutant mice lacking agrin, MuSK, or rapsyn.
Brain research. Developmental brain research 1999;114(2):171-8.
1999: Tonra J R; Ono M; Liu X; Garcia K; Jackson C; Yancopoulos G D; Wiegand S J; Wong V
Brain-derived neurotrophic factor improves blood glucose control and alleviates fasting hyperglycemia in C57BLKS-Lepr(db)/lepr(db) mice.
Diabetes 1999;48(3):588-94.
1999: Valenzuela D M; Griffiths J A; Rojas J; Aldrich T H; Jones P F; Zhou H; McClain J; Copeland N G; Gilbert D J; Jenkins N A; Huang T; Papadopoulos N; Maisonpierre P C; Davis S; Yancopoulos G D
Angiopoietins 3 and 4: diverging gene counterparts in mice and humans.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):1904-9.
1999: Papapetropoulos A; García-Cardeña G; Dengler T J; Maisonpierre P C; Yancopoulos G D; Sessa W C
Direct actions of angiopoietin-1 on human endothelium: evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors.
Laboratory investigation; a journal of technical methods and pathology 1999;79(2):213-23.
1999: Binder D K; Routbort M J; Ryan T E; Yancopoulos G D; McNamara J O
Selective inhibition of kindling development by intraventricular administration of TrkB receptor body.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(4):1424-36.
1999: Croll S D; Suri C; Compton D L; Simmons M V; Yancopoulos G D; Lindsay R M; Wiegand S J; Rudge J S; Scharfman H E
Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex.
Neuroscience 1999;93(4):1491-506.
1999: Grosios K; Leek J P; Markham A F; Yancopoulos G D; Jones P F
Assignment of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3-->q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping.
Cytogenetics and cell genetics 1999;84(1-2):118-20.
1999: Davis S; Yancopoulos G D
The angiopoietins: Yin and Yang in angiogenesis.
Current topics in microbiology and immunology 1999;237():173-85.
1998: Torres R; Firestein B L; Dong H; Staudinger J; Olson E N; Huganir R L; Bredt D S; Gale N W; Yancopoulos G D
PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands.
Neuron 1998;21(6):1453-63.
1998: Suri C; McClain J; Thurston G; McDonald D M; Zhou H; Oldmixon E H; Sato T N; Yancopoulos G D
Increased vascularization in mice overexpressing angiopoietin-1.
Science (New York, N.Y.) 1998;282(5388):468-71.
1998: Weis J; Lie D C; Ragoss U; Züchner S L; Schröder J M; Karpati G; Farruggella T; Stahl N; Yancopoulos G D; DiStefano P S
Increased expression of CNTF receptor alpha in denervated human skeletal muscle.
Journal of neuropathology and experimental neurology 1998;57(9):850-7.
1998: Bowen D C; Park J S; Bodine S; Stark J L; Valenzuela D M; Stitt T N; Yancopoulos G D; Lindsay R M; Glass D J; DiStefano P S
Localization and regulation of MuSK at the neuromuscular junction.
Developmental biology 1998;199(2):309-19.
1998: Lin P; Buxton J A; Acheson A; Radziejewski C; Maisonpierre P C; Yancopoulos G D; Channon K M; Hale L P; Dewhirst M W; George S E; Peters K G
Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(15):8829-34.
1998: Sanes J R; Apel E D; Burgess R W; Emerson R B; Feng G; Gautam M; Glass D; Grady R M; Krejci E; Lichtman J W; Lu J T; Massoulié J; Miner J H; Moscoso L M; Nguyen Q; Nichol M; Noakes P G; Patton B L; Son Y J; Yancopoulos G D; Zhou H
Development of the neuromuscular junction: genetic analysis in mice.
Journal of physiology, Paris 1998;92(3-4):167-72.
1998: Sanes J R; Apel E D; Gautam M; Glass D; Grady R M; Martin P T; Nichol M C; Yancopoulos G D
Agrin receptors at the skeletal neuromuscular junction.
Annals of the New York Academy of Sciences 1998;841():1-13.
1998: Yancopoulos G D; Klagsbrun M; Folkman J
Vasculogenesis, angiogenesis, and growth factors: ephrins enter the fray at the border.
Cell 1998;93(5):661-4.
1998: Carpenter L R; Farruggella T J; Symes A; Karow M L; Yancopoulos G D; Stahl N
Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(11):6061-6.
1998: Carpenter L R; Yancopoulos G D; Stahl N
General mechanisms of cytokine receptor signaling.
Advances in protein chemistry 1998;52():109-40.
1997: Shrivastava A; Radziejewski C; Campbell E; Kovac L; McGlynn M; Ryan T E; Davis S; Goldfarb M P; Glass D J; Lemke G; Yancopoulos G D
An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors.
Molecular cell 1997;1(1):25-34.
1997: Habecker B A; Symes A J; Stahl N; Francis N J; Economides A; Fink J S; Yancopoulos G D; Landis S C
A sweat gland-derived differentiation activity acts through known cytokine signaling pathways.
The Journal of biological chemistry 1997;272(48):30421-8.
1997: Gale N W; Yancopoulos G D
Ephrins and their receptors: a repulsive topic?
Cell and tissue research 1997;290(2):227-41.
1997: Symes A; Stahl N; Reeves S A; Farruggella T; Servidei T; Gearan T; Yancopoulos G; Fink J S
The protein tyrosine phosphatase SHP-2 negatively regulates ciliary neurotrophic factor induction of gene expression.
Current biology : CB 1997;7(9):697-700.
1997: Krull C E; Lansford R; Gale N W; Collazo A; Marcelle C; Yancopoulos G D; Fraser S E; Bronner-Fraser M
Interactions of Eph-related receptors and ligands confer rostrocaudal pattern to trunk neural crest migration.
Current biology : CB 1997;7(8):571-80.
1997: Glass D J; Apel E D; Shah S; Bowen D C; DeChiara T M; Stitt T N; Sanes J R; Yancopoulos G D
Kinase domain of the muscle-specific receptor tyrosine kinase (MuSK) is sufficient for phosphorylation but not clustering of acetylcholine receptors: required role for the MuSK ectodomain?
Proceedings of the National Academy of Sciences of the United States of America 1997;94(16):8848-53.
1997: Maisonpierre P C; Suri C; Jones P F; Bartunkova S; Wiegand S J; Radziejewski C; Compton D; McClain J; Aldrich T H; Papadopoulos N; Daly T J; Davis S; Sato T N; Yancopoulos G D
Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis.
Science (New York, N.Y.) 1997;277(5322):55-60.
1997: Apel E D; Glass D J; Moscoso L M; Yancopoulos G D; Sanes J R
Rapsyn is required for MuSK signaling and recruits synaptic components to a MuSK-containing scaffold.
Neuron 1997;18(4):623-35.
1997: Ezzeddine Z D; Yang X; DeChiara T; Yancopoulos G; Cepko C L
Postmitotic cells fated to become rod photoreceptors can be respecified by CNTF treatment of the retina.
Development (Cambridge, England) 1997;124(5):1055-67.
1997: Wong V; Glass D J; Arriaga R; Yancopoulos G D; Lindsay R M; Conn G
Hepatocyte growth factor promotes motor neuron survival and synergizes with ciliary neurotrophic factor.
The Journal of biological chemistry 1997;272(8):5187-91.
1996: Suri C; Jones P F; Patan S; Bartunkova S; Maisonpierre P C; Davis S; Sato T N; Yancopoulos G D
Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis.
Cell 1996;87(7):1171-80.
1996: Davis S; Aldrich T H; Jones P F; Acheson A; Compton D L; Jain V; Ryan T E; Bruno J; Radziejewski C; Maisonpierre P C; Yancopoulos G D
Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning.
Cell 1996;87(7):1161-9.
1996: Lai K O; Glass D J; Geis D; Yancopoulos G D; Ip N Y
Structural determinants of Trk receptor specificities using BDNF-based neurotrophin chimeras.
Journal of neuroscience research 1996;46(5):618-29.
1996: Flenniken A M; Gale N W; Yancopoulos G D; Wilkinson D G
Distinct and overlapping expression patterns of ligands for Eph-related receptor tyrosine kinases during mouse embryogenesis.
Developmental biology 1996;179(2):382-401.
1996: Lindsay R M; Yancopoulos G D
GDNF in a bind with known orphan: accessory implicated in new twist.
Neuron 1996;17(4):571-4.
1996: Holland S J; Gale N W; Mbamalu G; Yancopoulos G D; Henkemeyer M; Pawson T
Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands.
Nature 1996;383(6602):722-5.
1996: Gale N W; Flenniken A; Compton D C; Jenkins N; Copeland N G; Gilbert D J; Davis S; Wilkinson D G; Yancopoulos G D
Elk-L3, a novel transmembrane ligand for the Eph family of receptor tyrosine kinases, expressed in embryonic floor plate, roof plate and hindbrain segments.
Oncogene 1996;13(6):1343-52.
1996: Erickson J T; Conover J C; Borday V; Champagnat J; Barbacid M; Yancopoulos G; Katz D M
Mice lacking brain-derived neurotrophic factor exhibit visceral sensory neuron losses distinct from mice lacking NT4 and display a severe developmental deficit in control of breathing.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(17):5361-71.
1996: Gale N W; Holland S J; Valenzuela D M; Flenniken A; Pan L; Ryan T E; Henkemeyer M; Strebhardt K; Hirai H; Wilkinson D G; Pawson T; Davis S; Yancopoulos G D
Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis.
Neuron 1996;17(1):9-19.
1996: Bianchi L M; Conover J C; Fritzsch B; DeChiara T; Lindsay R M; Yancopoulos G D
Degeneration of vestibular neurons in late embryogenesis of both heterozygous and homozygous BDNF null mutant mice.
Development (Cambridge, England) 1996;122(6):1965-73.
1996: Glass D J; Bowen D C; Stitt T N; Radziejewski C; Bruno J; Ryan T E; Gies D R; Shah S; Mattsson K; Burden S J; DiStefano P S; Valenzuela D M; DeChiara T M; Yancopoulos G D
Agrin acts via a MuSK receptor complex.
Cell 1996;85(4):513-23.
1996: DeChiara T M; Bowen D C; Valenzuela D M; Simmons M V; Poueymirou W T; Thomas S; Kinetz E; Compton D L; Rojas E; Park J S; Smith C; DiStefano P S; Glass D J; Burden S J; Yancopoulos G D
The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo.
Cell 1996;85(4):501-12.
1996: Faris M; Ensoli B; Stahl N; Yancopoulos G; Nguyen A; Wang S; Nel A E
Differential activation of the extracellular signal-regulated kinase, Jun kinase and Janus kinase-Stat pathways by oncostatin M and basic fibroblast growth factor in AIDS-derived Kaposi's sarcoma cells.
AIDS (London, England) 1996;10(4):369-78.
1996: Bellido T; Stahl N; Farruggella T J; Borba V; Yancopoulos G D; Manolagas S C
Detection of receptors for interleukin-6, interleukin-11, leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor in bone marrow stromal/osteoblastic cells.
The Journal of clinical investigation 1996;97(2):431-7.
1996: Glass D J; DeChiara T M; Stitt T N; DiStefano P S; Valenzuela D M; Yancopoulos G D
The receptor tyrosine kinase MuSK is required for neuromuscular junction formation and is a functional receptor for agrin.
Cold Spring Harbor symposia on quantitative biology 1996;61():435-44.
1996: Ip N Y; Yancopoulos G D
The neurotrophins and CNTF: two families of collaborative neurotrophic factors.
Annual review of neuroscience 1996;19():491-515.
1995: Economides A N; Ravetch J V; Yancopoulos G D; Stahl N
Designer cytokines: targeting actions to cells of choice.
Science (New York, N.Y.) 1995;270(5240):1351-3.
1995: DeChiara T M; Vejsada R; Poueymirou W T; Acheson A; Suri C; Conover J C; Friedman B; McClain J; Pan L; Stahl N; Ip N Y; Yancopoulos G D
Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth.
Cell 1995;83(2):313-22.
1995: Boulton T G; Zhong Z; Wen Z; Darnell J E; Stahl N; Yancopoulos G D
STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(15):6915-9.
1995: Rydén M; Murray-Rust J; Glass D; Ilag L L; Trupp M; Yancopoulos G D; McDonald N Q; Ibáñez C F
Functional analysis of mutant neurotrophins deficient in low-affinity binding reveals a role for p75LNGFR in NT-4 signalling.
The EMBO journal 1995;14(9):1979-90.
1995: Valenzuela D M; Rojas E; Griffiths J A; Compton D L; Gisser M; Ip N Y; Goldfarb M; Yancopoulos G D
Identification of full-length and truncated forms of Ehk-3, a novel member of the Eph receptor tyrosine kinase family.
Oncogene 1995;10(8):1573-80.
1995: Stahl N; Farruggella T J; Boulton T G; Zhong Z; Darnell J E; Yancopoulos G D
Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors.
Science (New York, N.Y.) 1995;267(5202):1349-53.
1995: Acheson A; Conover J C; Fandl J P; DeChiara T M; Russell M; Thadani A; Squinto S P; Yancopoulos G D; Lindsay R M
A BDNF autocrine loop in adult sensory neurons prevents cell death.
Nature 1995;374(6521):450-3.
1995: Ilag L L; Curtis R; Glass D; Funakoshi H; Tobkes N J; Ryan T E; Acheson A; Lindsay R M; Persson H; Yancopoulos G D
Pan-neurotrophin 1: a genetically engineered neurotrophic factor displaying multiple specificities in peripheral neurons in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(2):607-11.
1995: Ip N Y; Yancopoulos G D
Neurotrophic factors and their receptors.
Progress in brain research 1995;105():189-95.
1994: Davis S; Gale N W; Aldrich T H; Maisonpierre P C; Lhotak V; Pawson T; Goldfarb M; Yancopoulos G D
Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity.
Science (New York, N.Y.) 1994;266(5186):816-9.
1994: Stahl N; Yancopoulos G D
The tripartite CNTF receptor complex: activation and signaling involves components shared with other cytokines.
Journal of neurobiology 1994;25(11):1454-66.
1994: Ip N Y; Boulton T G; Li Y; Verdi J M; Birren S J; Anderson D J; Yancopoulos G D
CNTF, FGF, and NGF collaborate to drive the terminal differentiation of MAH cells into postmitotic neurons.
Neuron 1994;13(2):443-55.
1994: Hantzopoulos P A; Suri C; Glass D J; Goldfarb M P; Yancopoulos G D
The low affinity NGF receptor, p75, can collaborate with each of the Trks to potentiate functional responses to the neurotrophins.
Neuron 1994;13(1):187-201.
1994: Rudge J S; Li Y; Pasnikowski E M; Mattsson K; Pan L; Yancopoulos G D; Wiegand S J; Lindsay R M; Ip N Y
Neurotrophic factor receptors and their signal transduction capabilities in rat astrocytes.
The European journal of neuroscience 1994;6(5):693-705.
1994: Verdi J M; Ip N; Yancopoulos G D; Anderson D J
Expression of trk in MAH cells lacking the p75 low-affinity nerve growth factor receptor is sufficient to permit nerve growth factor-induced differentiation to postmitotic neurons.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(9):3949-53.
1994: Boulton T G; Stahl N; Yancopoulos G D
Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors.
The Journal of biological chemistry 1994;269(15):11648-55.
1994: Helgren M E; Squinto S P; Davis H L; Parry D J; Boulton T G; Heck C S; Zhu Y; Yancopoulos G D; Lindsay R M; DiStefano P S
Trophic effect of ciliary neurotrophic factor on denervated skeletal muscle.
Cell 1994;76(3):493-504.
1994: Stahl N; Boulton T G; Ip N; Davis S; Yancopoulos G D
The tails of two proteins: the scrapie prion protein and the ciliary neurotrophic factor receptor.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1994;27(2):297-301.
1993: Maisonpierre P C; Barrezueta N X; Yancopoulos G D
Ehk-1 and Ehk-2: two novel members of the Eph receptor-like tyrosine kinase family with distinctive structures and neuronal expression.
Oncogene 1993;8(12):3277-88.
1993: Conover J C; Ip N Y; Poueymirou W T; Bates B; Goldfarb M P; DeChiara T M; Yancopoulos G D
Ciliary neurotrophic factor maintains the pluripotentiality of embryonic stem cells.
Development (Cambridge, England) 1993;119(3):559-65.
1993: Glass D J; Yancopoulos G D
The neurotrophins and their receptors.
Trends in cell biology 1993;3(8):262-8.
1993: Stahl N; Yancopoulos G D
The alphas, betas, and kinases of cytokine receptor complexes.
Cell 1993;74(4):587-90.
1993: Ip N Y; Li Y; Yancopoulos G D; Lindsay R M
Cultured hippocampal neurons show responses to BDNF, NT-3, and NT-4, but not NGF.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993;13(8):3394-405.
1993: Davis S; Aldrich T H; Stahl N; Pan L; Taga T; Kishimoto T; Ip N Y; Yancopoulos G D
LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor.
Science (New York, N.Y.) 1993;260(5115):1805-8.
1993: Maisonpierre P C; Goldfarb M; Yancopoulos G D; Gao G
Distinct rat genes with related profiles of expression define a TIE receptor tyrosine kinase family.
Oncogene 1993;8(6):1631-7.
1993: Valenzuela D M; Maisonpierre P C; Glass D J; Rojas E; Nuñez L; Kong Y; Gies D R; Stitt T N; Ip N Y; Yancopoulos G D
Alternative forms of rat TrkC with different functional capabilities.
Neuron 1993;10(5):963-74.
1993: Ip N Y; Stitt T N; Tapley P; Klein R; Glass D J; Fandl J; Greene L A; Barbacid M; Yancopoulos G D
Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells.
Neuron 1993;10(2):137-49.
1993: Ip N Y; McClain J; Barrezueta N X; Aldrich T H; Pan L; Li Y; Wiegand S J; Friedman B; Davis S; Yancopoulos G D
The alpha component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development.
Neuron 1993;10(1):89-102.
1992: LaVail M M; Unoki K; Yasumura D; Matthes M T; Yancopoulos G D; Steinberg R H
Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(23):11249-53.
1992: Nye S H; Squinto S P; Glass D J; Stitt T N; Hantzopoulos P; Macchi M J; Lindsay N S; Ip N Y; Yancopoulos G D
K-252a and staurosporine selectively block autophosphorylation of neurotrophin receptors and neurotrophin-mediated responses.
Molecular biology of the cell 1992;3(6):677-86.
1992: Maisonpierre P C; Belluscio L; Conover J C; Yancopoulos G D
Gene sequences of chicken BDNF and NT-3.
DNA sequence : the journal of DNA sequencing and mapping 1992;3(1):49-54.
1992: Glass D J; Gies D R; Stitt T; Davis S; Hantzopoulos P; Ip N Y; Goldfarb M; Yancopoulos G D
Cloning and analysis of neurotrophic factor receptors using function-based strategies.
Cold Spring Harbor symposia on quantitative biology 1992;57():53-62.
1992: Ip N Y; Yancopoulos G D
Ciliary neurotrophic factor and its receptor complex.
Progress in growth factor research 1992;4(2):139-55.
1991: Maisonpierre P C; Le Beau M M; Espinosa R; Ip N Y; Belluscio L; de la Monte S M; Squinto S; Furth M E; Yancopoulos G D
Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations.
Genomics 1991;10(3):558-68.
1991: Seger R; Ahn N G; Boulton T G; Yancopoulos G D; Panayotatos N; Radziejewska E; Ericsson L; Bratlien R L; Cobb M H; Krebs E G
Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(14):6142-6.
1991: Glass D J; Nye S H; Hantzopoulos P; Macchi M J; Squinto S P; Goldfarb M; Yancopoulos G D
TrkB mediates BDNF/NT-3-dependent survival and proliferation in fibroblasts lacking the low affinity NGF receptor.
Cell 1991;66(2):405-13.
1991: Davis S; Aldrich T H; Valenzuela D M; Wong V V; Furth M E; Squinto S P; Yancopoulos G D
The receptor for ciliary neurotrophic factor.
Science (New York, N.Y.) 1991;253(5015):59-63.
1991: Boulton T G; Nye S H; Robbins D J; Ip N Y; Radziejewska E; Morgenbesser S D; DePinho R A; Panayotatos N; Cobb M H; Yancopoulos G D
ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF.
Cell 1991;65(4):663-75.
1991: Hyman C; Hofer M; Barde Y A; Juhasz M; Yancopoulos G D; Squinto S P; Lindsay R M
BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra.
Nature 1991;350(6315):230-2.
1991: Ip N Y; Maisonpierre P; Alderson R; Friedman B; Furth M E; Panayotatos N; Squinto S; Yancopoulos G D; Lindsay R M
The neurotrophins and CNTF: specificity of action towards PNS and CNS neurons.
Journal de physiologie 1991;85(3):123-30.
1990: Squinto S P; Aldrich T H; Lindsay R M; Morrissey D M; Panayotatos N; Bianco S M; Furth M E; Yancopoulos G D
Identification of functional receptors for ciliary neurotrophic factor on neuronal cell lines and primary neurons.
Neuron 1990;5(6):757-66.
1990: Maisonpierre P C; Belluscio L; Friedman B; Alderson R F; Wiegand S J; Furth M E; Lindsay R M; Yancopoulos G D
NT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression.
Neuron 1990;5(4):501-9.
1990: Boulton T G; Yancopoulos G D; Gregory J S; Slaughter C; Moomaw C; Hsu J; Cobb M H
An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control.
Science (New York, N.Y.) 1990;249(4964):64-7.
1990: Maisonpierre P C; Belluscio L; Squinto S; Ip N Y; Furth M E; Lindsay R M; Yancopoulos G D
Neurotrophin-3: a neurotrophic factor related to NGF and BDNF.
Science (New York, N.Y.) 1990;247(4949 Pt 1):1446-51.
1990: Yancopoulos G D; Maisonpierre P C; Ip N Y; Aldrich T H; Belluscio L; Boulton T G; Cobb M H; Squinto S P; Furth M E
Neurotrophic factors, their receptors, and the signal transduction pathways they activate.
Cold Spring Harbor symposia on quantitative biology 1990;55():371-9.

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