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Bo Yang

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TOP 3
Xiaoxue Dou; Qiaojun He; Chunqi Hu; Xin Li; Liu Tao; Bo Yang; Lei Zhang; Yongzhou Hu
Synthesis and Biological Evaluation of Novel Pyrimido[4,5-b]quinoline-2,4- dione Derivatives as MDM2 Ubiquitin Ligase Inhibitors.
Ningbo Liao; Shiguo Chen; Shilei Dong; Nian Wu; Bo Yang; Xingqian Ye; Jianjun Zhong; Donghong Liu
Antioxidant and anti-tumor activity of a polysaccharide from freshwater clam, Corbicula fluminea.
Xiao-Chun Yang; Hong Zhu; Ji Cao; Qiao-jun He; Yong-zhou Hu; Si-Da Liao; Shi-Jing Qian; Li Wang; Bo Yang
GL3, a Novel 4β-Anilino-4'-O-Demethyl-4-Desoxypodophyllotoxin Analog, Traps Topoisomerase II Cleavage Complexes and Exerts Anticancer Activities.

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All Publications

2013: Xiaoxue Dou; Qiaojun He; Chunqi Hu; Xin Li; Liu Tao; Bo Yang; Lei Zhang; Yongzhou Hu
Synthesis and Biological Evaluation of Novel Pyrimido[4,5-b]quinoline-2,4- dione Derivatives as MDM2 Ubiquitin Ligase Inhibitors.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2013;9(4):581-7.
2013: Ningbo Liao; Shiguo Chen; Shilei Dong; Nian Wu; Bo Yang; Xingqian Ye; Jianjun Zhong; Donghong Liu
Antioxidant and anti-tumor activity of a polysaccharide from freshwater clam, Corbicula fluminea.
Food & function 2013;4(4):539-48.
2013: Xiao-Chun Yang; Hong Zhu; Ji Cao; Qiao-jun He; Yong-zhou Hu; Si-Da Liao; Shi-Jing Qian; Li Wang; Bo Yang
GL3, a Novel 4β-Anilino-4'-O-Demethyl-4-Desoxypodophyllotoxin Analog, Traps Topoisomerase II Cleavage Complexes and Exerts Anticancer Activities.
Translational oncology 2013;6(1):75-82.
2013: Meidan Ying; Like Zhong; Xinglu Zhou; Hui Jing; Nengming Lin; Peihua Luo; Hua Song; Bo Yang; Xiaochun Yang; Qiaojun He
Bortezomib sensitizes human acute myeloid leukemia cells to all-trans-retinoic acid-induced differentiation by modifying the RARα/STAT1 axis.
Molecular cancer therapeutics 2013;12(2):195-206.
2013: Meimei Si; Lei Tang; Honghai Wu; Youyou Yan; Bo Yang; Qiaojun He; Haoshu Wu
A novel indole derivative compound GY3 improves glucose and lipid metabolism via activation of AMP-activated protein kinase pathway.
European journal of pharmacology 2013;698(1-3):480-8.
2013: Siyue Lou; Tao Xue; Bo Yang; Xiaochun Yang; Meidan Ying; Yuqin Zhao; Like Zhong; Difeng Zhu; Renhua Gai; Qiaojun He
Efficacy of all-trans retinoid acid in preventing nickel induced cardiotoxicity in myocardial cells of rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013;51():251-8.
2013: Xinglu Zhou; Yanfen Fang; Hui Jing; Peihua Luo; Hua Song; Bo Yang; Like Zhong; Qiaojun He
Involvement of mitogen-activated protein kinase in signal transducer and activator of transcription-1 mediated differentiation induced by bortezomib in acute myeloid leukemia cells.
Molecular carcinogenesis 2013;52(1):18-28.
2012: Chang-xin Zhou; Hong Zhu; Li Zou; Qiao-jun He; Bo Yang; Zong-Zheng Zhao; Li-She Gan
Terpenoids from Cichorium intybus.
Natural product communications 2012;7(8):971-2.
2012: Tao Xue; Bo Yang; Xiaochun Yang; Yuqin Zhao; Hong Zhu; Renhua Gai; Peihua Luo; Honghai Wu; Youping Wu; Qiaojun He
Oxidative stress is involved in Dasatinib-induced apoptosis in rat primary hepatocytes.
Toxicology and applied pharmacology 2012;261(3):280-91.
2012: Peng Wu; Bo Yang; Qiaojun He; Xiaowen Liu; Yi Su; Yongzhou Hu
Discovery of novel 2-piperidinol-3-(arylsulfonyl)quinoxalines as phosphoinositide 3-kinase α (PI3Kα) inhibitors.
Bioorganic & medicinal chemistry 2012;20(9):2837-44.
2012: Xiaowu Dong; Jiadi Gao; Tao Liu; Dong Lu; Peng Wu; Jingying Yan; Bo Yang; Yongzhou Hu
QSAR models for isoindolinone-based p53-MDM2 interaction inhibitors using linear and non-linear statistical methods.
Chemical biology & drug design 2012;79(5):691-702.
2012: Xin Li; Shijing Qian; Bo Yang; Lin Zheng; Qiaojun He; Yongzhou Hu
A mechanism-based fluorescent probe for labeling O6-methylguanine-DNA methyltransferase in live cells.
Organic & biomolecular chemistry 2012;10(16):3189-91.
2012: Qinjie Weng; Xiaomei Xu; Bo Yang; Eve Seuntjens; Elliott H Sherr; Weinian Shou; Veronique van den Berghe; Haibo Wang; Polina Bukshpun; Ying Chen; Yan Chen; Qiaojun He; Yujiro Higashi; Danny Huylebroeck; Steven G Kernie; Q Richard Lu
Dual-mode modulation of Smad signaling by Smad-interacting protein Sip1 is required for myelination in the central nervous system.
Neuron 2012;73(4):713-28.
2012: Hong Zhu; Wei Yang; Lin Zheng; Wan-jing Ding; Ling-juan He; Qiao-jun He; Ping Huang; Si-da Liao; Wei Lu; Bo Yang
Upregulating Noxa by ER stress, celastrol exerts synergistic anti-cancer activity in combination with ABT-737 in human hepatocellular carcinoma cells.
PloS one 2012;7(12):e52333.
2011: Xiaowu Dong; Qiaojun He; Jianzhong Chen; Hui Jing; Tao Liu; Bo Yang; Xinglu Zhou; Yongzhou Hu
Pharmacophore identification, virtual screening and biological evaluation of prenylated flavonoids derivatives as PKB/Akt1 inhibitors.
European journal of medicinal chemistry 2011;46(12):5949-58.
2011: Qinjie Weng; Honghai Wu; Qing Xia; Ji Cao; Qiaojun He; Yongzhou Hu; Rong Sheng; Duoduo Wang; Jun Zhang; Difeng Zhu; Hong Zhu; Bo Yang
Q39, a quinoxaline 1,4-Di-N-oxide derivative, inhibits hypoxia-inducible factor-1α expression and the Akt/mTOR/4E-BP1 signaling pathway in human hepatoma cells.
Investigational new drugs 2011;29(6):1177-87.
2011: Peng Wu; Jianchao Xu; Bo Yang; Yong Ye; Lei Zhang; Shufang Huang; Yani Li; Tao Liu; Xiaowen Liu; Yi Su; Shaoyu Weng; Qiaojun He; Yongzhou Hu
Synthesis and biological evaluation of novel 2-arylamino-3-(arylsulfonyl)quinoxalines as PI3Kα inhibitors.
European journal of medicinal chemistry 2011;46(11):5540-8.
2011: Lili Ou; Bo Yang; Jian-Zhong Chen; Wenbo Ding; Giulianotti Marc; Shuang Han; Ping Jia; Jose Medina-Franco; Yongping Yu
Parallel synthesis of novel antitumor agents: 1,2,3-triazoles bearing biologically active sulfonamide moiety and their 3D-QSAR.
Molecular diversity 2011;15(4):927-46.
2011: Lin Zheng; Hong Zhu; Wei Yang; Chong Zhang; Wan-jing Ding; Qiao-jun He; Neng-ming Lin; Hong-hai Wu; Bo Yang
GDC-0941 sensitizes breast cancer to ABT-737 in vitro and in vivo through promoting the degradation of Mcl-1.
Cancer letters 2011;309(1):27-36.
2011: Danqing Xu; Difeng Zhu; Hong Zhu; Ji Cao; Qiaojun He; Chunqi Hu; Yongzhou Hu; Lin Li; Jianshu Lou; Shijing Qian; Qinjie Weng; Bo Yang
5k, a novel β-O-demethyl-epipodophyllotoxin analogue, inhibits the proliferation of cancer cells in vitro and in vivo via the induction of G2 arrest and apoptosis.
Investigational new drugs 2011;29(5):786-99.
2011: Chunqi Hu; Xiaowu Dong; Xin Li; Rong Sheng; Lulu Tao; Weisi Wang; Bo Yang; Lei Zhang; Yongzhou Hu
Design, synthesis, and biological evaluation of imidazoline derivatives as p53-MDM2 binding inhibitors.
Bioorganic & medicinal chemistry 2011;19(18):5454-61.
2011: Chong Zhang; Hong Zhu; Liu-qing Yang; Tian-yu Cai; Xiao-wu Dong; Qiao-jun He; Yong-zhou Hu; Hai Jiang; Neng-ming Lin; Bo Yang
Synergistic antitumor activity of gemcitabine and ABT-737 in vitro and in vivo through disrupting the interaction of USP9X and Mcl-1.
Molecular cancer therapeutics 2011;10(7):1264-75.
2011: Tao Liu; Rong Cui; Jing Chen; Jun Zhang; Qiaojun He; Bo Yang; Yongzhou Hu
4,5-Diaryl-3-aminopyrazole derivatives as analogs of Combretastatin A-4: synthesis and biological evaluation.
Archiv der Pharmazie 2011;344(5):279-86.
2011: Jing Chen; Tao Liu; Rui Wu; Jianshu Lou; Xiaowu Dong; Qiaojun He; Bo Yang; Yongzhou Hu
Design, synthesis, and biological evaluation of novel γ-carboline ketones as anticancer agents.
European journal of medicinal chemistry 2011;46(4):1343-7.
2011: Qing Xia; Ling Zhang; Jun Zhang; Rong Sheng; Bo Yang; Qiaojun He; Yongzhou Hu
Synthesis, hypoxia-selective cytotoxicity of new 3-amino-1,2,4-benzotriazine-1,4-dioxide derivatives.
European journal of medicinal chemistry 2011;46(3):919-26.
2011: Chong Zhang; Rui Wu; Hong Zhu; Yong-zhou Hu; Hai Jiang; Neng-ming Lin; Qiao-jun He; Bo Yang
Enhanced anti-tumor activity by the combination of TRAIL/Apo-2L and combretastatin A-4 against human colon cancer cells via induction of apoptosis in vitro and in vivo.
Cancer letters 2011;302(1):11-9.
2011: Peihua Luo; Bo Yang; Lin Li; Meili Lin; Qiaojun He
The proteasome inhibitor bortezomib enhances ATRA-induced differentiation of neuroblastoma cells via the JNK mitogen-activated protein kinase pathway.
PloS one 2011;6(11):e27298.
2011: Xiaowu Dong; Jiadi Gao; Tao Liu; Yanming Wang; Peng Wu; Jianchao Xu; Bo Yang; Yongzhou Hu
Flavonoids as vasorelaxant agents: synthesis, biological evaluation and quantitative structure activities relationship (QSAR) studies.
Molecules (Basel, Switzerland) 2011;16(10):8257-72.
2011: Li Wang; Fenyan Yang; Xiaochun Yang; Xianghong Guan; Chunqi Hu; Tao Liu; Qiaojun He; Bo Yang; Yongzhou Hu
Synthesis and biological evaluation of new 4β-anilino-4'-O-demethyl-4-desoxypodophyllotoxin derivatives as potential antitumor agents.
European journal of medicinal chemistry 2011;46(1):285-96.
2011: Yanfen Fang; Xinglu Zhou; Meihua Lin; Meidan Ying; Peihua Luo; Difeng Zhu; Jianshu Lou; Bo Yang; Qiaojun He
Inhibition of all-trans-retinoic acid-induced proteasome activation potentiates the differentiating effect of retinoid in acute myeloid leukemia cells.
Molecular carcinogenesis 2011;50(1):24-35.
2010: Jing Chen; Tao Liu; Rui Wu; Jianshu Lou; Ji Cao; Xiaowu Dong; Bo Yang; Qiaojun He; Yongzhou Hu
Design, synthesis, and biological evaluation of novel N-γ-carboline arylsulfonamides as anticancer agents.
Bioorganic & medicinal chemistry 2010;18(24):8478-84.
2010: Yanfen Fang; Xinglu Zhou; Meihua Lin; Hui Jing; Like Zhong; Meidan Ying; Peihua Luo; Bo Yang; Qiaojun He
The ubiquitin-proteasome pathway plays essential roles in ATRA-induced leukemia cells G0/G1 phase arrest and transition into granulocytic differentiation.
Cancer biology & therapy 2010;10(11):1157-67.
2010: Shijing Qian; Ji Cao; Yan Yan; Maotang Sun; Hong Zhu; Yongzhou Hu; Qiaojun He; Bo Yang
SMT-A07, a 3-(Indol-2-yl) indazole derivative, induces apoptosis of leukemia cells in vitro.
Molecular and cellular biochemistry 2010;345(1-2):13-21.
2010: Xiao-Chun Yang; Chong-Xing Tu; Pei-Hua Luo; Hong Zhu; Di-Feng Zhu; Hong-Hai Wu; Xing-Lu Zhou; Wei Lu; Qiao-jun He; Bo Yang
Antimetastatic activity of MONCPT in preclinical melanoma mice model.
Investigational new drugs 2010;28(6):800-11.
2010: Hong Zhu; Xiao-Wen Liu; Wan-Jing Ding; Dan-Qing Xu; Yu-Chen Zhao; Wei Lu; Qiao-jun He; Bo Yang
Up-regulation of death receptor 4 and 5 by celastrol enhances the anti-cancer activity of TRAIL/Apo-2L.
Cancer letters 2010;297(2):155-64.
2010: Xiao-Wen Liu; Yi Su; Hong Zhu; Ji Cao; Wan-Jing Ding; Yu-Chen Zhao; Qiao-jun He; Bo Yang
HIF-1α-dependent autophagy protects HeLa cells from fenretinide (4-HPR)-induced apoptosis in hypoxia.
Pharmacological research : the official journal of the Italian Pharmacological Society 2010;62(5):416-25.
2010: Yuqin Zhao; Tao Xue; Xiaochun Yang; Hong Zhu; Xiaofei Ding; Liming Lou; Wei Lu; Bo Yang; Qiaojun He
Autophagy plays an important role in sunitinib-mediated cell death in H9c2 cardiac muscle cells.
Toxicology and applied pharmacology 2010;248(1):20-7.
2010: Xiaowu Dong; Lilin Du; Zhichao Pan; Tao Liu; Bo Yang; Yongzhou Hu
Synthesis and biological evaluation of novel hybrid chalcone derivatives as vasorelaxant agents.
European journal of medicinal chemistry 2010;45(9):3986-92.
2010: Hui Jing; Xinglu Zhou; Xiaowu Dong; Ji Cao; Hong Zhu; Jianshu Lou; Yongzhou Hu; Qiaojun He; Bo Yang
Abrogation of Akt signaling by Isobavachalcone contributes to its anti-proliferative effects towards human cancer cells.
Cancer letters 2010;294(2):167-77.
2010: Xin Li; Shijing Qian; Qiaojun He; Bo Yang; Jia Li; Yongzhou Hu
Design and synthesis of a highly selective fluorescent turn-on probe for thiol bioimaging in living cells.
Organic & biomolecular chemistry 2010;8(16):3627-30.
2010: Xiaowu Dong; Li Wang; Xueqin Huang; Tao Liu; Erqing Wei; Lilin Du; Bo Yang; Yongzhou Hu
Pharmacophore identification, synthesis, and biological evaluation of carboxylated chalcone derivatives as CysLT1 antagonists.
Bioorganic & medicinal chemistry 2010;18(15):5519-27.
2010: Hong Zhu; Xiao-Wen Liu; Tian-Yu Cai; Ji Cao; Chong-Xing Tu; Wei Lu; Qiao-jun He; Bo Yang
Celastrol acts as a potent antimetastatic agent targeting beta1 integrin and inhibiting cell-extracellular matrix adhesion, in part via the p38 mitogen-activated protein kinase pathway.
The Journal of pharmacology and experimental therapeutics 2010;334(2):489-99.
2010: Hong Zhu; Jun Zhang; Na Xue; Yongzhou Hu; Bo Yang; Qiaojun He
Novel combretastatin A-4 derivative XN0502 induces cell cycle arrest and apoptosis in A549 cells.
Investigational new drugs 2010;28(4):493-501.
2010: Wanjing Ding; Tianyu Cai; Hong Zhu; Rui Wu; Chongxing Tu; Liuqing Yang; Wei Lu; Qiaojun He; Bo Yang
Synergistic antitumor effect of TRAIL in combination with sunitinib in vitro and in vivo.
Cancer letters 2010;293(2):158-66.
2010: Mei-mei Si; Jian-shu Lou; Chang-xin Zhou; Juan-Na Shen; Hong-Hai Wu; Bo Yang; Qiao-jun He; Hao-shu Wu
Insulin releasing and alpha-glucosidase inhibitory activity of ethyl acetate fraction of Acorus calamus in vitro and in vivo.
Journal of ethnopharmacology 2010;128(1):154-9.
2010: Peihua Luo; Meihua Lin; Meili Lin; Difeng Zhu; Zhen Wang; Jingshan Shen; Bo Yang; Qiaojun He
Bortezomib induces apoptosis in human neuroblastoma CHP126 cells.
Die Pharmazie 2010;65(3):213-8.
2010: Chong Zhang; Hong Zhu; Xiaochun Yang; Jianshu Lou; Difeng Zhu; Wei Lu; Qiaojun He; Bo Yang
P53 and p38 MAPK pathways are involved in MONCPT-induced cell cycle G2/M arrest in human non-small cell lung cancer A549.
Journal of cancer research and clinical oncology 2010;136(3):437-45.
2010: Chunqi Hu; Danqing Xu; Wenting Du; Shijing Qian; Li Wang; Jianshu Lou; Qiaojun He; Bo Yang; Yongzhou Hu
Novel 4 beta-anilino-podophyllotoxin derivatives: design synthesis and biological evaluation as potent DNA-topoisomerase II poisons and anti-MDR agents.
Molecular bioSystems 2010;6(2):410-20.
2010: Jun Zhang; Ji Cao; Qinjie Weng; Rui Wu; Yan Yan; Hui Jing; Hong Zhu; Qiaojun He; Bo Yang
Suppression of hypoxia-inducible factor 1α (HIF-1α) by tirapazamine is dependent on eIF2α phosphorylation rather than the mTORC1/4E-BP1 pathway.
PloS one 2010;5(11):e13910.
2010: Jianshu Lou; XingLu Zhou; Qinjie Weng; Duo-duo Wang; Qing Xia; Yongzhou Hu; Qiaojun He; Bo Yang; Peihua Luo
XQ2, a novel TPZ derivative, induced G2/M phase arrest and apoptosis under hypoxia in non-small cell lung cancer cells.
Bioscience, biotechnology, and biochemistry 2010;74(6):1181-7.
2010: Duoduo Wang; Qionghua Zhu; Xiayan Zhang; Lei Zhang; Qiaojun He; Bo Yang
Hypoxia promotes etoposide (VP-16) resistance in neuroblastoma CHP126 cells.
Die Pharmazie 2010;65(1):51-6.
2010: Hong Zhu; Wan-Jing Ding; Rui Wu; Qin-Jie Weng; Jian-Shu Lou; Rong-Jia Jin; Wei Lu; Bo Yang; Qiao-jun He
Synergistic anti-cancer activity by the combination of TRAIL/APO-2L and celastrol.
Cancer investigation 2010;28(1):23-32.
2010: Li Shen; Xiaochun Yang; Bo Yang; Qiaojun He; Yongzhou Hu
Novel hybrids from lamellarin D and combretastatin A 4 as cytotoxic agents.
European journal of medicinal chemistry 2010;45(1):11-8.
2009: Yue Zhu; Hai Jiang; Chong Zhang; Qiao-jun He; Bo Yang; yongzheng guo; Hong Zhu
MONCPT exerts anti-cancer activities via inducing G2/M arrest and apoptosis in human bladder cancer.
Die Pharmazie 2009;64(12):823-8.
2009: Rui Wu; Wanjing Ding; Tao Liu; Hong Zhu; Yongzhou Hu; Bo Yang; Qiaojun He
XN05, a novel synthesized microtubule inhibitor, exhibits potent activity against human carcinoma cells in vitro.
Cancer letters 2009;285(1):13-22.
2009: Rong Sheng; Xiao Lin; Jing Zhang; Kim Sun Chol; Wenhai Huang; Bo Yang; Qiaojun He; Yongzhou Hu
Design, synthesis and evaluation of flavonoid derivatives as potent AChE inhibitors.
Bioorganic & medicinal chemistry 2009;17(18):6692-8.
2009: Tao Liu; Xiaowu Dong; Na Xue; Rui Wu; Qiaojun He; Bo Yang; Yongzhou Hu
Synthesis and biological evaluation of 3,4-diaryl-5-aminoisoxazole derivatives.
Bioorganic & medicinal chemistry 2009;17(17):6279-85.
2009: Ji Cao; Danqing Xu; Duoduo Wang; Rui Wu; Lei Zhang; Hong Zhu; Qiaojun He; Bo Yang
ROS-driven Akt dephosphorylation at Ser-473 is involved in 4-HPR-mediated apoptosis in NB4 cells.
Free radical biology & medicine 2009;47(5):536-47.
2009: Lei Zhang; Jun Zhang; Chunqi Hu; Ji Cao; Xinglu Zhou; Yongzhou Hu; Qiaojun He; Bo Yang
Efficient activation of p53 pathway in A549 cells exposed to L2, a novel compound targeting p53-MDM2 interaction.
Anti-cancer drugs 2009;20(6):416-24.
2009: Peihua Luo; Meili Lin; Meihua Lin; Yiyu Chen; Bo Yang; Qiaojun He
Function of retinoid acid receptor alpha and p21 in all-trans-retinoic acid-induced acute T-lymphoblastic leukemia apoptosis.
Leukemia & lymphoma 2009;50(7):1183-9.
2009: Qing Ye; Ji Cao; Xinglu Zhou; De-Shui Lv; Qiaojun He; Bo Yang; Yongzhou Hu
Synthesis and evaluation of novel 7-azaindazolyl-indolyl-maleimide derivatives as antitumor agents and protein kinase C inhibitors.
Bioorganic & medicinal chemistry 2009;17(13):4763-72.
2009: Jing Zhang; Difeng Zhu; Rong Sheng; Honghai Wu; Yongzhou Hu; Feng Wang; Tianyu Cai; Bo Yang; Qiaojun He
BZYX, a novel acetylcholinesterase inhibitor, significantly improved chemicals-induced learning and memory impairments on rodents and protected PC12 cells from apoptosis induced by hydrogen peroxide.
European journal of pharmacology 2009;613(1-3):1-9.
2009: Hao-shu Wu; Di-Feng Zhu; Chang-xin Zhou; Chu-Rui Feng; Yi-Jia Lou; Bo Yang; Qiao-jun He
Insulin sensitizing activity of ethyl acetate fraction of Acorus calamus L. in vitro and in vivo.
Journal of ethnopharmacology 2009;123(2):288-92.
2009: Jing Chen; Xiaowu Dong; Tao Liu; Jianshu Lou; Chaoyi Jiang; Wenhai Huang; Qiaojun He; Bo Yang; Yongzhou Hu
Design, synthesis, and quantitative structure-activity relationship of cytotoxic gamma-carboline derivatives.
Bioorganic & medicinal chemistry 2009;17(9):3324-31.
2009: Duoduo Wang; Qinjie Weng; Lei Zhang; Qiaojun He; Bo Yang
VEGF and Bcl-2 interact via MAPKs signaling pathway in the response to hypoxia in neuroblastoma.
Cellular and molecular neurobiology 2009;29(3):391-401.
2009: Min Han; Cai-Xia He; Qiu-Li Fang; Xiao-Chun Yang; Yuan-Yuan Diao; Dong-Hang Xu; Qiao-jun He; Yong-zhou Hu; Wen-Quan Liang; Bo Yang; Jian-Qing Gao
A novel camptothecin derivative incorporated in nano-carrier induced distinguished improvement in solubility, stability and anti-tumor activity both in vitro and in vivo.
Pharmaceutical research 2009;26(4):926-35.
2009: Yanhong Shen; Jing Zhang; Rong Sheng; Xiaowu Dong; Qiaojun He; Bo Yang; Yongzhou Hu
Synthesis and biological evaluation of novel flavonoid derivatives as dual binding acetylcholinesterase inhibitors.
Journal of enzyme inhibition and medicinal chemistry 2009;24(2):372-80.
2009: Jing Chen; Jianshu Lou; Tao Liu; Ru Wu; Xiaowu Dong; Qiaojun He; Bo Yang; Yongzhou Hu
Synthesis and in-vitro antitumor activities of some mannich bases of 9-alkyl-1,2,3,4-tetrahydrocarbazole-1-ones.
Archiv der Pharmazie 2009;342(3):165-72.
2009: Ping Jia; Rong Sheng; Jing Zhang; Liang Fang; Qiaojun He; Bo Yang; Yongzhou Hu
Design, synthesis and evaluation of galanthamine derivatives as acetylcholinesterase inhibitors.
European journal of medicinal chemistry 2009;44(2):772-84.
2009: Ji Cao; Lei Zhang; Qing Ye; Xinglu Zhou; Jianshu Lou; Difeng Zhu; Yongzhou Hu; Qiaojun He; Bo Yang
YQ36: a novel bisindolylmaleimide analogue induces KB/VCR cell death.
Journal of biomedicine & biotechnology 2009;2009():535072.
2009: Rong Sheng; Yu Xu; Chunqi Hu; Jing Zhang; Xiao Lin; Jingya Li; Bo Yang; Qiaojun He; Yongzhou Hu
Design, synthesis and AChE inhibitory activity of indanone and aurone derivatives.
European journal of medicinal chemistry 2009;44(1):7-17.
2008: Guo-Lan Wu; Han-liang Zhou; Jian-Zhong Shentu; Qiao-jun He; Bo Yang
Determination of lansoprazole in human plasma by rapid resolution liquid chromatography-electrospray tandem mass spectrometry: application to a bioequivalence study on Chinese volunteers.
Journal of pharmaceutical and biomedical analysis 2008;48(5):1485-9.
2008: Liang Fang; Li Shen; Yanfen Fang; Yongzhou Hu; Qiaojun He; Bo Yang
MZ3 can induce G2/M-phase arrest and apoptosis in human leukemia cells.
Journal of cancer research and clinical oncology 2008;134(12):1337-45.
2008: Bo Zhang; Yu Luo; Qinjie Weng; Qiaojun He; Wei Lu; Bo Yang
CPT21, a novel compound with anti-proliferative effect against gastric cancer cell SGC7901.
Investigational new drugs 2008;26(6):517-24.
2008: Bo Yang; Qin Gao; Hui Yao; Qiang Xia
[Mitochondrial mechanism of cardioprotective effect of puerarin against H202-stress in rats].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 2008;24(4):399-404.
2008: Yanhong Shen; Rong Sheng; Jing Zhang; Qiaojun He; Bo Yang; Yongzhou Hu
2-Phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors: a study on the importance of modifications at the side chain on the activity.
Bioorganic & medicinal chemistry 2008;16(16):7646-53.
2008: Danqing Xu; Liang Fang; Qionghua Zhu; Yongzhou Hu; Qiaojun He; Bo Yang
Antimultidrug-resistant effect and mechanism of a novel CA-4 analogue MZ3 on leukemia cells.
Die Pharmazie 2008;63(7):528-33.
2008: Meidan Ying; Chongxing Tu; Huazhou Ying; Yongzhou Hu; Qiaojun He; Bo Yang
MSFTZ, a flavanone derivative, induces human hepatoma cell apoptosis via a reactive oxygen species- and caspase-dependent mitochondrial pathway.
The Journal of pharmacology and experimental therapeutics 2008;325(3):758-65.
2008: Gui-Qing Xu; Chong Zhang; Lei Zhang; Xing-Lu Zhou; Bo Yang; Qiao-jun He; Yong-zhou Hu
Synthesis, cytotoxicity and protein kinase C inhibition of arylpyrrolylmaleimides.
Archiv der Pharmazie 2008;341(5):273-80.
2008: Qinjie Weng; Duoduo Wang; Peng Guo; Liang Fang; Yongzhou Hu; Qiaojun He; Bo Yang
Q39, a novel synthetic Quinoxaline 1,4-Di-N-oxide compound with anti-cancer activity in hypoxia.
European journal of pharmacology 2008;581(3):262-9.
2008: Na Xue; Xiaochun Yang; Rui Wu; Jing Chen; Qiaojun He; Bo Yang; Xiuyang Lu; Yongzhou Hu
Synthesis and biological evaluation of imidazol-2-one derivatives as potential antitumor agents.
Bioorganic & medicinal chemistry 2008;16(5):2550-7.
2008: Bo Zhang; Yanfen Fang; Ji Cao; Chong Zhang; Meidan Ying; Qiaojun He; Bo Yang
Involvement of immune response in anti-tumor effects of Staphylococcus aureus filtrate preparation.
Journal of cancer research and clinical oncology 2008;134(3):373-9.
2007: Qin Gao; Bo Yang; Zhi-guo Ye; Jue Wang; Iain C Bruce; Qiang Xia
Opening the calcium-activated potassium channel participates in the cardioprotective effect of puerarin.
European journal of pharmacology 2007;574(2-3):179-84.
2007: Ying-Yin Li; Hao-shu Wu; Lei Tang; Chu-Rui Feng; Juan-Hong Yu; Yu Li; Yu-She Yang; Bo Yang; Qiao-jun He
The potential insulin sensitizing and glucose lowering effects of a novel indole derivative in vitro and in vivo.
Pharmacological research : the official journal of the Italian Pharmacological Society 2007;56(4):335-43.
2007: Wenting Du; Lan Hong; Tongwei Yao; Xiaochun Yang; Qiaojun He; Bo Yang; Yongzhou Hu
Synthesis and evaluation of water-soluble docetaxel prodrugs-docetaxel esters of malic acid.
Bioorganic & medicinal chemistry 2007;15(18):6323-30.
2007: Gui-Qing Xu; Peng Guo; Chong Zhang; Qiao-jun He; Bo Yang; Yong-zhou Hu
Synthesis and cytotoxicity of indolopyrrolemaleimides.
Chemical & pharmaceutical bulletin 2007;55(9):1302-7.
2007: Xiaochun Yang; Chong Zhang; Meidan Ying; Bo Yang; Qiaojun He
Antiproliferation in human EA.hy926 endothelial cells and inhibition of VEGF expression in PC-3 cells by topotecan.
Die Pharmazie 2007;62(7):534-8.
2007: Faqin Jiang; Qinjie Weng; Rong Sheng; Qing Xia; Qiaojun He; Bo Yang; Yongzhou Hu
Synthesis, structure and hypoxic cytotoxicity of 3-amino-1,2,4-benzotriazine-1,4-dioxide derivatives.
Archiv der Pharmazie 2007;340(5):258-63.
2007: Huazhou Ying; Yongzhou Hu; Qiaojun He; Runping Li; Bo Yang
Synthesis and anticancer activity of a novel class of flavonoids: 2,4-diarylchromane[4,3-d]-delta(1,9b)-1,2,3-thiadiazolines.
European journal of medicinal chemistry 2007;42(2):226-34.
2007: Liang Fang; Qiaojun He; Yongzhou Hu; Bo Yang
MZ3 induces apoptosis in human leukemia cells.
Cancer chemotherapy and pharmacology 2007;59(3):397-405.
2007: Jianzhong Shentu; Bo Zhang; Lingling Fan; Qioajun He; Bo Yang; Zhi Chen
Anti-proliferative activity of fenretinide in human hepatoma cells in vitro and in vivo.
Anti-cancer drugs 2007;18(1):47-53.
2007: Tao Liu; Zhongmiao Xu; Qiaojun He; Yanhong Chen; Bo Yang; Yongzhou Hu
Nitrogen-containing flavonoids as CDK1/Cyclin B inhibitors: design, synthesis, and biological evaluation.
Bioorganic & medicinal chemistry letters 2007;17(1):278-81.
2006: Xiaochun Yang; Peihua Luo; Bo Yang; Qiaojun He
Antiangiogenesis response of endothelial cells to the antitumour drug 10-methoxy-9-nitrocamptothecin.
Pharmacological research : the official journal of the Italian Pharmacological Society 2006;54(5):334-40.
2006: Bo Yang; Lingling Fan; Liang Fang; Qiaojun He
Hypoxia-mediated fenretinide (4-HPR) resistance in childhood acute lymphoblastic leukemia cells.
Cancer chemotherapy and pharmacology 2006;58(4):540-6.
2006: Faqin Jiang; Bo Yang; Lingling Fan; Qiaojun He; Yongzhou Hu
Synthesis and hypoxic-cytotoxic activity of some 3-amino-1,2,4-benzotriazine-1,4-dioxide derivatives.
Bioorganic & medicinal chemistry letters 2006;16(16):4209-13.
2006: Qiaojun He; Runping Li; Liang Fang; Huazhou Ying; Yongzhou Hu; Bo Yang
Antileukemia activity of MSFTZ-a novel flavanone analog.
Anti-cancer drugs 2006;17(6):641-7.
2006: Peihua Luo; Qiaojun He; Xungui He; Yongzhou Hu; Wei Lu; Yiyu Cheng; Bo Yang
Potent antitumor activity of 10-methoxy-9-nitrocamptothecin.
Molecular cancer therapeutics 2006;5(4):962-8.
2006: Bo Yang; Qiao-jun He; Da-Yuan Zhu; Yi-Jia Lou; Rui-ying Fang
Antiproliferative activity of contragestazol (DL111-IT) in murine and human tumor models in vitro and in vivo.
Cancer chemotherapy and pharmacology 2006;57(2):268-73.
2005: Qiao-jun He; Bo Yang; Yi-Jia Lou; Rui-ying Fang
Contragestazol (DL111-IT) inhibits proliferation of human androgen-independent prostate cancer cell line PC3 in vitro and in vivo.
Asian journal of andrology 2005;7(4):389-93.
2003: Qiao-jun He; Bo Yang; Wei-fang Wang; Hong-Hai Wu; Rui-ying Fang
Synergistic effects of DL111-IT in combination with mifepristone and misoprostol on termination of early pregnancy in preclinical studies.
Contraception 2003;68(4):289-95.
2000: Bo Yang; H J Zhou; Qiao-jun He; Rui-ying Fang
Termination of early pregnancy in the mouse, rat and hamster with DL111-IT and RU486.
Contraception 2000;62(4):211-6.
2000: Qiao-jun He; Yibin Ying; Bo Yang; Rui-ying Fang
Synergistic effects of DL111-IT combined with mifepristone on termination of early pregnancy in rhesus monkeys.
Contraception 2000;62(4):189-93.