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De Yang

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De Yang; Michael Bustin; Gonzalo de la Rosa; Takashi Furusawa; Theresa Gioannini; Dennis Klinman; Yana Li; Yuri V Postnikov; Poonam Tewary; Feng Wei; Jerrold P Weiss; Joost J Oppenheim
High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses.
Poonam Tewary; De Yang; Gonzalo de la Rosa; Yana Li; Michael W Finn; Alan M Krensky; Carol Clayberger; Joost J Oppenheim
Granulysin activates antigen-presenting cells through TLR4 and acts as an immune alarmin.
Johann Röhrl; De Yang; Joost J Oppenheim; Thomas Hehlgans
Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2.

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All Publications

2012: De Yang; Michael Bustin; Gonzalo de la Rosa; Takashi Furusawa; Theresa Gioannini; Dennis Klinman; Yana Li; Yuri V Postnikov; Poonam Tewary; Feng Wei; Jerrold P Weiss; Joost J Oppenheim
High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses.
The Journal of experimental medicine 2012;209(1):157-71.
2010: Poonam Tewary; De Yang; Gonzalo de la Rosa; Yana Li; Michael W Finn; Alan M Krensky; Carol Clayberger; Joost J Oppenheim
Granulysin activates antigen-presenting cells through TLR4 and acts as an immune alarmin.
Blood 2010;116(18):3465-74.
2010: Johann Röhrl; De Yang; Joost J Oppenheim; Thomas Hehlgans
Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(12):6688-94.
2010: De Yang; Poonam Tewary; Gonzalo de la Rosa; Feng Wei; Joost J Oppenheim
The alarmin functions of high-mobility group proteins.
Biochimica et biophysica acta 2010;1799(1-2):157-63.
2008: Gonzalo de la Rosa; De Yang; Poonam Tewary; Atul Varadhachary; Joost J Oppenheim
Lactoferrin acts as an alarmin to promote the recruitment and activation of APCs and antigen-specific immune responses.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(10):6868-76.
2008: De Yang; Qian Chen; Shao Bo Su; Ping Zhang; Kahori Kurosaka; Rachel R Caspi; Suzanne M Michalek; Helene F Rosenberg; Ning Zhang; Joost J Oppenheim
Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses.
The Journal of experimental medicine 2008;205(1):79-90.
2007: De Yang; Zhen-hua Liu; Poonam Tewary; Qian Chen; Gonzalo de la Rosa; Joost J Oppenheim
Defensin participation in innate and adaptive immunity.
Current pharmaceutical design 2007;13(30):3131-9.
2007: Joost J Oppenheim; Poonam Tewary; Gonzalo de la Rosa; De Yang
Alarmins initiate host defense.
Advances in experimental medicine and biology 2007;601():185-94.
2007: De Yang; Qian Chen; Huan Yang; Kevin Tracey; Michael Bustin; Joost J Oppenheim
High mobility group box-1 protein induces the migration and activation of human dendritic cells and acts as an alarmin.
Journal of leukocyte biology 2007;81(1):59-66.
2006: Ning Zhang; De Yang; Huifang Dong; Qian Chen; Dessislava I Dimitrova; Thomas J Rogers; Michail V Sitkovsky; Joost J Oppenheim
Adenosine A2a receptors induce heterologous desensitization of chemokine receptors.
Blood 2006;108(1):38-44.
2006: Marzena Pazgier; David M Hoover; De Yang; Wuyuan Lu; Jacek Lubkowski
Human beta-defensins.
Cellular and molecular life sciences : CMLS 2006;63(11):1294-313.
2005: Joost J Oppenheim; De Yang
Alarmins: chemotactic activators of immune responses.
Current opinion in immunology 2005;17(4):359-65.
2005: Kahori Kurosaka; Qian Chen; Felix Yarovinsky; Joost J Oppenheim; De Yang
Mouse cathelin-related antimicrobial peptide chemoattracts leukocytes using formyl peptide receptor-like 1/mouse formyl peptide receptor-like 2 as the receptor and acts as an immune adjuvant.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(10):6257-65.
2004: Qian Chen; David Wade; Kahori Kurosaka; Zhao Yuan Wang; Joost J Oppenheim; De Yang
Temporin A and related frog antimicrobial peptides use formyl peptide receptor-like 1 as a receptor to chemoattract phagocytes.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(4):2652-9.
2004: De Yang; Arya Biragyn; David M Hoover; Jacek Lubkowski; Joost J Oppenheim
Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense.
Annual review of immunology 2004;22():181-215.
2003: Joost J Oppenheim; Arya Biragyn; Larry W Kwak; De Yang
Roles of antimicrobial peptides such as defensins in innate and adaptive immunity.
Annals of the rheumatic diseases 2003;62 Suppl 2():ii17-21.
2003: De Yang; Qian Chen; David M Hoover; Patricia Staley; Kenneth D Tucker; Jacek Lubkowski; Joost J Oppenheim
Many chemokines including CCL20/MIP-3alpha display antimicrobial activity.
Journal of leukocyte biology 2003;74(3):448-55.
2003: Zhibin Wu; David M Hoover; De Yang; Cyril Boulegue; Fanny Santamaria; Joost J Oppenheim; Jacek Lubkowski; Wuyuan Lu
Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human beta-defensin 3.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(15):8880-5.
2002: David M Hoover; Cyril Boulegue; De Yang; Joost J Oppenheim; Kenneth Tucker; Wuyuan Lu; Jacek Lubkowski
The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins.
The Journal of biological chemistry 2002;277(40):37647-54.
2002: De Yang; Qian Chen; Barry Gertz; Rong He; Michele Phulsuksombati; Richard D Ye; Joost J Oppenheim
Human dendritic cells express functional formyl peptide receptor-like-2 (FPRL2) throughout maturation.
Journal of leukocyte biology 2002;72(3):598-607.
2002: De Yang; Arya Biragyn; Larry W Kwak; Joost J Oppenheim
Mammalian defensins in immunity: more than just microbicidal.
Trends in immunology 2002;23(6):291-6.
2002: Joost J Oppenheim; De Yang; Arya Biragyn; O M Zack Howard; Paul H Plotz
Chemokine receptors on dendritic cells promote autoimmune reactions.
Arthritis research 2002;4 Suppl 3():S183-8.
2001: De Yang; Oleg Chertov; Joost J Oppenheim
The role of mammalian antimicrobial peptides and proteins in awakening of innate host defenses and adaptive immunity.
Cellular and molecular life sciences : CMLS 2001;58(7):978-89.
2001: S Yamashiro; Hidenobu Kamohara; Ji Ming Wang; De Yang; Wang Hua Gong; Teizo Yoshimura
Phenotypic and functional change of cytokine-activated neutrophils: inflammatory neutrophils are heterogeneous and enhance adaptive immune responses.
Journal of leukocyte biology 2001;69(5):698-704.
2001: De Yang; Oleg Chertov; Joost J Oppenheim
Participation of mammalian defensins and cathelicidins in anti-microbial immunity: receptors and activities of human defensins and cathelicidin (LL-37).
Journal of leukocyte biology 2001;69(5):691-7.
2001: De Yang; Q Chen; Yingying Le; Ji Ming Wang; Joost J Oppenheim
Differential regulation of formyl peptide receptor-like 1 expression during the differentiation of monocytes to dendritic cells and macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(6):4092-8.
2000: X Chen; De Yang; W Shen; Hui Fang Dong; Ji Ming Wang; Joost J Oppenheim; M Z Howard
Characterization of chenodeoxycholic acid as an endogenous antagonist of the G-coupled formyl peptide receptors.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2000;49(12):744-55.
2000: S Yamashiro; Ji Ming Wang; De Yang; Wang Hua Gong; Hidenobu Kamohara; Teizo Yoshimura
Expression of CCR6 and CD83 by cytokine-activated human neutrophils.
Blood 2000;96(12):3958-63.
2000: De Yang; Q Chen; S Stoll; X Chen; O M Zack Howard; Joost J Oppenheim
Differential regulation of responsiveness to fMLP and C5a upon dendritic cell maturation: correlation with receptor expression.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(5):2694-702.
1999: De Yang; Oleg Chertov; Svetlana N Bykovskaia; Q Chen; MJ Buffo; Jeffrey Shogan; M Anderson; Jens Schröder; Ji Ming Wang; O M Zack Howard; Joost J Oppenheim
Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6.
Science (New York, N.Y.) 1999;286(5439):525-8.
1999: De Yang; O M Zack Howard; Q Chen; Joost J Oppenheim
Cutting edge: immature dendritic cells generated from monocytes in the presence of TGF-beta 1 express functional C-C chemokine receptor 6.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(4):1737-41.