FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

David Brigstock

Research Profile

Chemicals & Drugs

Anatomy

Phenomena

Blotting, Western

Disorders

Fibrosis

Co-author Network

Publications

TOP 3
Rosalyn D Abbott; David R Brigstock; Damien Laudier; Robert D Monsey; Devina Purmessur; James C Iatridis
Degenerative Grade Affects the Responses of Human Nucleus Pulposus Cells to Link-N, CTGF, and TGFβ3.
Alyssa Charrier; David R Brigstock
Regulation of pancreatic function by connective tissue growth factor (CTGF, CCN2).
Ming Xiu; Rui-Juan Zhang; David R Brigstock; Fang-Hui He; Ya-Hui Liu; Run-Ping Gao
Connective tissue growth factor is overexpressed in human hepatocellular carcinoma and promotes cell invasion and growth.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of David Brigstock (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Rosalyn D Abbott; David R Brigstock; Damien Laudier; Robert D Monsey; Devina Purmessur; James C Iatridis
Degenerative Grade Affects the Responses of Human Nucleus Pulposus Cells to Link-N, CTGF, and TGFβ3.
Journal of spinal disorders & techniques 2013;26(3):E86-94.
2013: Alyssa Charrier; David R Brigstock
Regulation of pancreatic function by connective tissue growth factor (CTGF, CCN2).
Cytokine & growth factor reviews 2013;24(1):59-68.
2012: Ming Xiu; Rui-Juan Zhang; David R Brigstock; Fang-Hui He; Ya-Hui Liu; Run-Ping Gao
Connective tissue growth factor is overexpressed in human hepatocellular carcinoma and promotes cell invasion and growth.
World journal of gastroenterology : WJG 2012;18(47):7070-8.
2012: Rong-Li Piao; Man-Li Zhang; Jie Zhu; David R Brigstock; Run-Ping Gao
Clinical significance of connective tissue growth factor in hepatitis B virus-induced hepatic fibrosis.
World journal of gastroenterology : WJG 2012;18(18):2280-6.
2012: Guangcun Huang; Gail E Besner; David R Brigstock
Heparin-binding epidermal growth factor-like growth factor suppresses experimental liver fibrosis in mice.
Laboratory investigation; a journal of technical methods and pathology 2012;92(5):703-12.
2012: Tirumuru Nagaraja; Appakkudal R Anand; Anuradha Balasubramanian; David R Brigstock; Li Chen; Kalpana Ghoshal; Jerome E Groopman; Samson T Jacob; Andrew Leask; Ramesh K Ganju
Activation of the connective tissue growth factor (CTGF)-transforming growth factor β 1 (TGF-β 1) axis in hepatitis C virus-expressing hepatocytes.
PloS one 2012;7(10):e46526.
2012: Guangcun Huang; David R Brigstock
Regulation of hepatic stellate cells by connective tissue growth factor.
Frontiers in bioscience : a journal and virtual library 2012;17():2495-507.
2011: Li Chen; Samuel W French; Andrew Leask; Alyssa L Charrier; David R Brigstock
Ethanol-stimulated differentiated functions of human or mouse hepatic stellate cells are mediated by connective tissue growth factor.
Journal of hepatology 2011;55(2):399-406.
2011: Guangcun Huang; David R Brigstock
Integrin expression and function in the response of primary culture hepatic stellate cells to connective tissue growth factor (CCN2).
Journal of cellular and molecular medicine 2011;15(5):1087-95.
2010: Alyssa L Charrier; David R Brigstock
Connective tissue growth factor production by activated pancreatic stellate cells in mouse alcoholic chronic pancreatitis.
Laboratory investigation; a journal of technical methods and pathology 2010;90(8):1179-88.
2010: David R Brigstock
Connective tissue growth factor (CCN2, CTGF) and organ fibrosis: lessons from transgenic animals.
Journal of cell communication and signaling 2010;4(1):1-4.
2009: Zhenyue Tong; Ruju Chen; Daniel S Alt; Sherri Kemper; Bernard Perbal; David R Brigstock
Susceptibility to liver fibrosis in mice expressing a connective tissue growth factor transgene in hepatocytes.
Hepatology (Baltimore, Md.) 2009;50(3):939-47.
2009: Run-Ping Gao; David R Brigstock
Connective tissue growth factor hammerhead ribozyme attenuates human hepatic stellate cell function.
World journal of gastroenterology : WJG 2009;15(30):3807-13.
2009: Carmel Lawrencia; Alyssa Charrier; Guangcun Huang; David R Brigstock
Ethanol-mediated expression of connective tissue growth factor (CCN2) in mouse pancreatic stellate cells.
Growth factors (Chur, Switzerland) 2009;27(2):91-9.
2009: David R Brigstock
Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo.
Journal of cell communication and signaling 2009;3(1):5-18.
2009: Laura A Crawford; Michelle A Guney; Young Ah Oh; R Andrea Deyoung; David M Valenzuela; Andrew J Murphy; George D Yancopoulos; Karen M Lyons; David R Brigstock; Aris Economides; Maureen Gannon
Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis.
Molecular endocrinology (Baltimore, Md.) 2009;23(3):324-36.
2008: Andrew Leask; Daphne Pala; Shaoqiong Chen; David R Brigstock
Regulation of CCN2 mRNA expression and promoter activity in activated hepatic stellate cells.
Journal of cell communication and signaling 2008;2(1-2):49-56.
2007: Richard A Dean; Georgina S Butler; Yamina Hamma-Kourbali; Jean Delbé; David R Brigstock; José Courty; Christopher M Overall
Identification of candidate angiogenic inhibitors processed by matrix metalloproteinase 2 (MMP-2) in cell-based proteomic screens: disruption of vascular endothelial growth factor (VEGF)/heparin affin regulatory peptide (pleiotrophin) and VEGF/Connective tissue growth factor angiogenic inhibitory complexes by MMP-2 proteolysis.
Molecular and cellular biology 2007;27(24):8454-65.
2007: Joanne M Boag; Alex H Beesley; Martin J Firth; Joseph R Freitas; Jette Ford; David R Brigstock; Nicholas H de Klerk; Ursula R Kees
High expression of connective tissue growth factor in pre-B acute lymphoblastic leukaemia.
British journal of haematology 2007;138(6):740-8.
2007: Christopher P Baran; Judy M Opalek; Sara McMaken; Christie A Newland; James O'Brien; Melissa G Hunter; Benjamin D Bringardner; Martha M Monick; David R Brigstock; Paul C Stromberg; Gary W Hunninghake; Clay B Marsh
Important roles for macrophage colony-stimulating factor, CC chemokine ligand 2, and mononuclear phagocytes in the pathogenesis of pulmonary fibrosis.
American journal of respiratory and critical care medicine 2007;176(1):78-89.
2006: R Gao; David R Brigstock
A novel integrin alpha5beta1 binding domain in module 4 of connective tissue growth factor (CCN2/CTGF) promotes adhesion and migration of activated pancreatic stellate cells.
Gut 2006;55(6):856-62.
2006: Zhen-Yue Tong; David R Brigstock
Intrinsic biological activity of the thrombospondin structural homology repeat in connective tissue growth factor.
The Journal of endocrinology 2006;188(3):R1-8.
2005: Runping Gao; David R Brigstock
Activation of nuclear factor kappa B (NF-kappaB) by connective tissue growth factor (CCN2) is involved in sustaining the survival of primary rat hepatic stellate cells.
Cell communication and signaling : CCS 2005;3():14.
2005: Runping Gao; David R Brigstock
Connective tissue growth factor (CCN2) in rat pancreatic stellate cell function: integrin alpha5beta1 as a novel CCN2 receptor.
Gastroenterology 2005;129(3):1019-30.
2005: David R Brigstock; Lester F Lau; Bernard Perbal
Report and abstracts of the 3rd International Workshop on the CCN Family of Genes. St Malo, France, 20-23 October 2004.
Journal of clinical pathology 2005;58(5):463-78.
2005: Iwona Cicha; Atilla Yilmaz; Michael Klein; Dieter Raithel; David R Brigstock; Werner G Daniel; Margarete Goppelt-Struebe; Christoph D. Garlichs
Connective tissue growth factor is overexpressed in complicated atherosclerotic plaques and induces mononuclear cell chemotaxis in vitro.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(5):1008-13.
2005: Jörg Köninger; Fabio F di Mola; Pierluigi Di Sebastiano; Andrea Gardini; David R Brigstock; Paolo Innocenti; Markus W Büchler; Helmut Friess
Transforming growth factor-beta pathway is activated in cholecystolithiasis.
Langenbeck's archives of surgery / Deutsche Gesellschaft für Chirurgie 2005;390(1):21-8.
2005: Amy W Rachfal; David R Brigstock
Structural and functional properties of CCN proteins.
Vitamins and hormones 2005;70():69-103.
2004: Amy W Rachfal; Mark Luquette; David R Brigstock
Expression of connective tissue growth factor (CCN2) in desmoplastic small round cell tumour.
Journal of clinical pathology 2004;57(4):422-5.
2004: Runping Gao; David R Brigstock
Connective tissue growth factor (CCN2) induces adhesion of rat activated hepatic stellate cells by binding of its C-terminal domain to integrin alpha(v)beta(3) and heparan sulfate proteoglycan.
The Journal of biological chemistry 2004;279(10):8848-55.
2004: Runping Gao; DeAnna Ball; Bernard Perbal; David R Brigstock
Connective tissue growth factor induces c-fos gene activation and cell proliferation through p44/42 MAP kinase in primary rat hepatic stellate cells.
Journal of hepatology 2004;40(3):431-8.
2004: Jian Fei Wang; Merle E Olson; Lingling Ma; David R Brigstock; David A Hart
Connective tissue growth factor siRNA modulates mRNA levels for a subset of molecules in normal and TGF-beta 1-stimulated porcine skin fibroblasts.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2004;12(2):205-16.
2004: Saman Rasoul; Oscar Carretero; Hongmei Peng; Maria A Cavasin; Jia L Zhuo; Alicia Sanchez-Mendoza; David R Brigstock; Nour-Eddine Rhaleb
Antifibrotic effect of Ac-SDKP and angiotensin-converting enzyme inhibition in hypertension.
Journal of hypertension 2004;22(3):593-603.
2003: Hongmei Peng; Oscar Carretero; David R Brigstock; Nancy Oja-Tebbe; Nour-Eddine Rhaleb
Ac-SDKP reverses cardiac fibrosis in rats with renovascular hypertension.
Hypertension 2003;42(6):1164-70.
2003: David R Brigstock
The CCN family: a new stimulus package.
The Journal of endocrinology 2003;178(2):169-75.
2003: Jian Fei Wang; Merle E Olson; DeAnna Ball; David R Brigstock; David A Hart
Recombinant connective tissue growth factor modulates porcine skin fibroblast gene expression.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2003;11(3):220-9.
2003: David R Brigstock; roel goldschmeding; Ken-ichi Katsube; Stephen C-T Lam; Lester F Lau; K Lyons; C Naus; Bernard Perbal; Bruce L Riser; M Takigawa; Herman Yeger
Proposal for a unified CCN nomenclature.
Molecular pathology : MP 2003;56(2):127-8.
2003: Bernard Perbal; David R Brigstock; Lester F Lau
Report on the second international workshop on the CCN family of genes.
Molecular pathology : MP 2003;56(2):80-5.
2003: DeAnna Ball; E E-D A Moussad; M A E Rageh; S A Kemper; David R Brigstock
Establishment of a recombinant expression system for connective tissue growth factor (CTGF) that models CTGF processing in utero.
Reproduction (Cambridge, England) 2003;125(2):271-84.
2003: DeAnna Ball; Amy W Rachfal; S A Kemper; David R Brigstock
The heparin-binding 10 kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion.
The Journal of endocrinology 2003;176(2):R1-7.
2002: E E-D A Moussad; M A E Rageh; AK Wilson; R D Geisert; David R Brigstock
Temporal and spatial expression of connective tissue growth factor (CCN2; CTGF) and transforming growth factor beta type 1 (TGF-beta1) at the utero-placental interface during early pregnancy in the pig.
Molecular pathology : MP 2002;55(3):186-92.
2002: David R Brigstock
Regulation of angiogenesis and endothelial cell function by connective tissue growth factor (CTGF) and cysteine-rich 61 (CYR61).
Angiogenesis 2002;5(3):153-65.
2002: Fabio F di Mola; Helmut Friess; Erick Riesle; Alexander Koliopanos; Peter Büchler; Zhaowen Zhu; David R Brigstock; Murray Korc; Markus W Büchler
Connective tissue growth factor is involved in pancreatic repair and tissue remodeling in human and rat acute necrotizing pancreatitis.
Annals of surgery 2002;235(1):60-7.
2001: M A E Rageh; E E-D A Moussad; AK Wilson; David R Brigstock
Steroidal regulation of connective tissue growth factor (CCN2; CTGF) synthesis in the mouse uterus.
Molecular pathology : MP 2001;54(5):338-46.
2001: C Ayer-Lelievre; David R Brigstock; Lester F Lau; D Pennica; Bernard Perbal; Herman Yeger
Report and abstracts on the first international workshop on the CCN family of genes.
Molecular pathology : MP 2001;54(2):105-20.
2001: K M Davis-Fleische; David R Brigstock; Gail E Besner
Site-directed mutagenesis of heparin-binding EGF-like growth factor (HB-EGF): analysis of O-glycosylation sites and properties.
Growth factors (Chur, Switzerland) 2001;19(2):127-43.
2000: Mehmet Uzumcu; M F Homsi; DeAnna Ball; Serdar Coskun; Kamal Jaroudi; hans hollanders; David R Brigstock
Localization of connective tissue growth factor in human uterine tissues.
Molecular human reproduction 2000;6(12):1093-8.
2000: E E-D A Moussad; David R Brigstock
Connective tissue growth factor: what's in a name?
Molecular genetics and metabolism 2000;71(1-2):276-92.
1999: David R Brigstock
The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family.
Endocrine reviews 1999;20(2):189-206.
1999: GA Surveyor; David R Brigstock
Immunohistochemical localization of connective tissue growth factor (CTGF) in the mouse embryo between days 7.5 and 14.5 of gestation.
Growth factors (Chur, Switzerland) 1999;17(2):115-24.
1999: Paul A Harding; K M Davis-Fleischer; M A Crissman-Combs; M T Miller; David R Brigstock; Gail E Besner
Induction of anchorage independent growth by heparin-binding EGF-like growth factor (HB-EGF).
Growth factors (Chur, Switzerland) 1999;17(1):49-61.
1998: GA Surveyor; AK Wilson; David R Brigstock
Localization of connective tissue growth factor during the period of embryo implantation in the mouse.
Biology of reproduction 1998;59(5):1207-13.
1998: DeAnna Ball; GA Surveyor; J R Diehl; CL Steffen; Mehmet Uzumcu; Mark A Mirando; David R Brigstock
Characterization of 16- to 20-kilodalton (kDa) connective tissue growth factors (CTGFs) and demonstration of proteolytic activity for 38-kDa CTGF in pig uterine luminal flushings.
Biology of reproduction 1998;59(4):828-35.
1998: Mehmet Uzumcu; David R Brigstock; Y C Lin
Partial purification and characterization of two non-FSH steroid-modulating factors in rat thymic epithelial cell-conditioned medium (TCM).
Domestic animal endocrinology 1998;15(3):155-68.
1998: Paul A Harding; GA Surveyor; David R Brigstock
Characterization of pig connective tissue growth factor (CTGF) cDNA, mRNA and protein from uterine tissue.
DNA sequence : the journal of DNA sequencing and mapping 1998;8(6):385-90.
1998: CL Steffen; DeAnna Ball; Paul A Harding; N Bhattacharyya; Srikumar B Pillai; David R Brigstock
Characterization of cell-associated and soluble forms of connective tissue growth factor (CTGF) produced by fibroblast cells in vitro.
Growth factors (Chur, Switzerland) 1998;15(3):199-213.
1997: MT Downing; David R Brigstock; Mark Luquette; M Crissman-Combs; Gail E Besner
Immunohistochemical localization of heparin-binding epidermal growth factor-like growth factor in normal skin and skin cancers.
The Histochemical journal 1997;29(10):735-44.
1997: David R Brigstock; CL Steffen; G Y Kim; Ravindra Kumar Vegunta; J R Diehl; Paul A Harding
Purification and characterization of novel heparin-binding growth factors in uterine secretory fluids. Identification as heparin-regulated Mr 10,000 forms of connective tissue growth factor.
The Journal of biological chemistry 1997;272(32):20275-82.
1996: David R Brigstock; G Y Kim; C L Steffen; A Liu; Ravindra Kumar Vegunta; N H Ismail
High molecular mass forms of epidermal growth factor in pig uterine secretions.
Journal of reproduction and fertility 1996;108(2):313-20.
1996: K M Davis; David R Brigstock; P R Johnson; M A Crissman-Combs; D W McCarthy; M T Downing; Gail E Besner
Production of glycosylated heparin-binding EGF-like growth factor in HeLa cells using vaccinia virus.
Protein expression and purification 1996;8(1):57-67.
1996: Paul A Harding; David R Brigstock; L Shen; M A Crissman-Combs; Gail E Besner
Characterization of the gene encoding murine heparin-binding epidermal growth factor-like growth factor.
Gene 1996;169(2):291-2.
1996: D W McCarthy; M T Downing; David R Brigstock; Mark Luquette; K D Brown; M S Abad; Gail E Besner
Production of heparin-binding epidermal growth factor-like growth factor (HB-EGF) at sites of thermal injury in pediatric patients.
The Journal of investigative dermatology 1996;106(1):49-56.
1996: David R Brigstock; G Y Kim; C L Steffen
Pig uterine luminal fluid contains the developmentally regulated neurotrophic factor, pleiotrophin.
The Journal of endocrinology 1996;148(1):103-11.
1995: Ravindra Kumar Vegunta; Damon Cooney; M T Downing; Gail E Besner; David R Brigstock
Unique protein expression by the TBJ clonal derivative of C1300 murine neuroblastoma.
Journal of pediatric surgery 1995;30(12):1668-72.
1995: G Y Kim; Gail E Besner; C L Steffen; D W McCarthy; M T Downing; Mark Luquette; M S Abad; David R Brigstock
Purification of heparin-binding epidermal growth factor-like growth factor from pig uterine luminal flushings, and its production by endometrial tissues.
Biology of reproduction 1995;52(3):561-71.
1992: Gail E Besner; D Whelton; M A Crissman-Combs; C L Steffen; G Y Kim; David R Brigstock
Interaction of heparin-binding EGF-like growth factor (HB-EGF) with the epidermal growth factor receptor: modulation by heparin, heparinase, or synthetic heparin-binding HB-EGF fragments.
Growth factors (Chur, Switzerland) 1992;7(4):289-96.