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David Brigstock

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

Concepts & Ideas

Molecular Sequence Data

Living Beings

Genes & Molecular Sequences

Amino Acid Sequence

Anatomy

Phenomena

Western Blotting

Procedures

High Pressure Liquid Chromatography

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Co-Publications
Name
9
Besner, Gail
7
Ball, DeAnna
5
Perbal, Bernard
5
Harding, Paul
4
Luquette, Mark
4
Moussad, E-D
4
Surveyor, GA
3
Uzumcu, Mehmet
3
Wilson, AK
3
Steffen, CL
3
Rachfal, Amy
3
Rageh, M A E
2
Olson, Merle
2
Peng, Hongmei
2
Rhaleb, Nour-Eddine

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Publications

TOP 3
Tong Zhenyue; Chen Ruju; Alt Daniel S; Kemper Sherri; Perbal Bernard; Brigstock David R
Susceptibility to liver fibrosis in mice expressing a connective tissue growth factor transgene in hepatocytes.
Gao Run-Ping; Brigstock David R
Connective tissue growth factor hammerhead ribozyme attenuates human hepatic stellate cell function.
Lawrencia Carmel; Charrier Alyssa; Huang Guangcun; Brigstock David R
Ethanol-mediated expression of connective tissue growth factor (CCN2) in mouse pancreatic stellate cells.

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All Publications

2009: Tong Zhenyue; Chen Ruju; Alt Daniel S; Kemper Sherri; Perbal Bernard; Brigstock David R
Susceptibility to liver fibrosis in mice expressing a connective tissue growth factor transgene in hepatocytes.
Hepatology (Baltimore, Md.) 2009;50(3):939-47.
2009: Gao Run-Ping; Brigstock David R
Connective tissue growth factor hammerhead ribozyme attenuates human hepatic stellate cell function.
World journal of gastroenterology : WJG 2009;15(30):3807-13.
2009: Lawrencia Carmel; Charrier Alyssa; Huang Guangcun; Brigstock David R
Ethanol-mediated expression of connective tissue growth factor (CCN2) in mouse pancreatic stellate cells.
Growth factors (Chur, Switzerland) 2009;27(2):91-9.
2009: Brigstock David R
Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo.
Journal of cell communication and signaling 2009;3(1):5-18.
2009: Crawford Laura A; Guney Michelle A; Oh Young Ah; Deyoung R Andrea; Valenzuela David M; Murphy Andrew J; Yancopoulos George D; Lyons Karen M; Brigstock David R; Economides Aris; Gannon Maureen
Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis.
Molecular endocrinology (Baltimore, Md.) 2009;23(3):324-36.
2007: Dean Richard A; Butler Georgina S; Hamma-Kourbali Yamina; Delbé Jean; Brigstock David R; Courty José; Overall Christopher M
Identification of candidate angiogenic inhibitors processed by matrix metalloproteinase 2 (MMP-2) in cell-based proteomic screens: disruption of vascular endothelial growth factor (VEGF)/heparin affin regulatory peptide (pleiotrophin) and VEGF/Connective tissue growth factor angiogenic inhibitory complexes by MMP-2 proteolysis.
Molecular and cellular biology 2007;27(24):8454-65.
2007: Boag Joanne M; Beesley Alex H; Firth Martin J; Freitas Joseph R; Ford Jette; Brigstock David R; de Klerk Nicholas H; Kees Ursula R
High expression of connective tissue growth factor in pre-B acute lymphoblastic leukaemia.
British journal of haematology 2007;138(6):740-8.
2007: Baran Christopher P; Opalek Judy M; McMaken Sara; Newland Christie A; O'Brien James M; Hunter Melissa G; Bringardner Benjamin D; Monick Martha M; Brigstock David R; Stromberg Paul C; Hunninghake Gary W; Marsh Clay B
Important roles for macrophage colony-stimulating factor, CC chemokine ligand 2, and mononuclear phagocytes in the pathogenesis of pulmonary fibrosis.
American journal of respiratory and critical care medicine 2007;176(1):78-89.
2006: Gao R; Brigstock D R
A novel integrin alpha5beta1 binding domain in module 4 of connective tissue growth factor (CCN2/CTGF) promotes adhesion and migration of activated pancreatic stellate cells.
Gut 2006;55(6):856-62.
2006: Tong Zhen-Yue; Brigstock David R
Intrinsic biological activity of the thrombospondin structural homology repeat in connective tissue growth factor.
The Journal of endocrinology 2006;188(3):R1-8.
2005: Gao Runping; Brigstock David R
Activation of nuclear factor kappa B (NF-kappaB) by connective tissue growth factor (CCN2) is involved in sustaining the survival of primary rat hepatic stellate cells.
Cell communication and signaling : CCS 2005;3():14.
2005: Gao Runping; Brigstock David R
Connective tissue growth factor (CCN2) in rat pancreatic stellate cell function: integrin alpha5beta1 as a novel CCN2 receptor.
Gastroenterology 2005;129(3):1019-30.
2005: Brigstock D; Lau L; Perbal B
Report and abstracts of the 3rd International Workshop on the CCN Family of Genes. St Malo, France, 20-23 October 2004.
Journal of clinical pathology 2005;58(5):463-78.
2005: Cicha Iwona; Yilmaz Atilla; Klein Michael; Raithel Dieter; Brigstock David R; Daniel Werner G; Goppelt-Struebe Margarete; Garlichs Christoph D
Connective tissue growth factor is overexpressed in complicated atherosclerotic plaques and induces mononuclear cell chemotaxis in vitro.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(5):1008-13.
2005: Köninger Jörg; di Mola Fabio F; Di Sebastiano Pierluigi; Gardini Andrea; Brigstock David R; Innocenti Paolo; Büchler Markus W; Friess Helmut
Transforming growth factor-beta pathway is activated in cholecystolithiasis.
Langenbeck's archives of surgery / Deutsche Gesellschaft für Chirurgie 2005;390(1):21-8.
2005: Rachfal Amy W; Brigstock David R
Structural and functional properties of CCN proteins.
Vitamins and hormones 2005;70():69-103.
2004: Rachfal A W; Luquette M H; Brigstock D R
Expression of connective tissue growth factor (CCN2) in desmoplastic small round cell tumour.
Journal of clinical pathology 2004;57(4):422-5.
2004: Gao Runping; Ball DeAnna K; Perbal Bernard; Brigstock David R
Connective tissue growth factor induces c-fos gene activation and cell proliferation through p44/42 MAP kinase in primary rat hepatic stellate cells.
Journal of hepatology 2004;40(3):431-8.
2004: Wang Jian Fei; Olson Merle E; Ma Lingling; Brigstock David R; Hart David A
Connective tissue growth factor siRNA modulates mRNA levels for a subset of molecules in normal and TGF-beta 1-stimulated porcine skin fibroblasts.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2004;12(2):205-16.
2004: Rasoul Saman; Carretero Oscar A; Peng Hongmei; Cavasin Maria A; Zhuo Jialong; Sanchez-Mendoza Alicia; Brigstock David R; Rhaleb Nour-Eddine
Antifibrotic effect of Ac-SDKP and angiotensin-converting enzyme inhibition in hypertension.
Journal of hypertension 2004;22(3):593-603.
2004: Gao Runping; Brigstock David R
Connective tissue growth factor (CCN2) induces adhesion of rat activated hepatic stellate cells by binding of its C-terminal domain to integrin alpha(v)beta(3) and heparan sulfate proteoglycan.
The Journal of biological chemistry 2004;279(10):8848-55.
2003: Peng Hongmei; Carretero Oscar A; Brigstock David R; Oja-Tebbe Nancy; Rhaleb Nour-Eddine
Ac-SDKP reverses cardiac fibrosis in rats with renovascular hypertension.
Hypertension 2003;42(6):1164-70.
2003: Brigstock D R
The CCN family: a new stimulus package.
The Journal of endocrinology 2003;178(2):169-75.
2003: Wang Jian Fei; Olson Merle E; Ball Deanna K; Brigstock David R; Hart David A
Recombinant connective tissue growth factor modulates porcine skin fibroblast gene expression.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2003;11(3):220-9.
2003: Brigstock D R; Goldschmeding R; Katsube K-i; Lam S C-T; Lau L F; Lyons K; Naus C; Perbal B; Riser B; Takigawa M; Yeger H
Proposal for a unified CCN nomenclature.
Molecular pathology : MP 2003;56(2):127-8.
2003: Perbal B; Brigstock D R; Lau L F
Report on the second international workshop on the CCN family of genes.
Molecular pathology : MP 2003;56(2):80-5.
2003: Ball D K; Moussad E E-D A; Rageh M A E; Kemper S A; Brigstock D R
Establishment of a recombinant expression system for connective tissue growth factor (CTGF) that models CTGF processing in utero.
Reproduction (Cambridge, England) 2003;125(2):271-84.
2003: Ball D K; Rachfal A W; Kemper S A; Brigstock D R
The heparin-binding 10 kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion.
The Journal of endocrinology 2003;176(2):R1-7.
2002: Moussad E E-D A; Rageh M A E; Wilson A K; Geisert R D; Brigstock D R
Temporal and spatial expression of connective tissue growth factor (CCN2; CTGF) and transforming growth factor beta type 1 (TGF-beta1) at the utero-placental interface during early pregnancy in the pig.
Molecular pathology : MP 2002;55(3):186-92.
2002: di Mola Fabio F; Friess Helmut; Riesle Erick; Koliopanos Alexander; Büchler Peter; Zhu Zhaowen; Brigstock David R; Korc Murray; Büchler Markus W
Connective tissue growth factor is involved in pancreatic repair and tissue remodeling in human and rat acute necrotizing pancreatitis.
Annals of surgery 2002;235(1):60-7.
2002: Brigstock David R
Regulation of angiogenesis and endothelial cell function by connective tissue growth factor (CTGF) and cysteine-rich 61 (CYR61).
Angiogenesis 2002;5(3):153-65.
2001: Rageh M A; Moussad E E; Wilson A K; Brigstock D R
Steroidal regulation of connective tissue growth factor (CCN2; CTGF) synthesis in the mouse uterus.
Molecular pathology : MP 2001;54(5):338-46.
2001: Ayer-Lelievre C; Brigstock D; Lau L; Pennica D; Perbal B; Yeger H
Report and abstracts on the first international workshop on the CCN family of genes.
Molecular pathology : MP 2001;54(2):105-20.
2001: Davis-Fleische K M; Brigstock D R; Besner G E
Site-directed mutagenesis of heparin-binding EGF-like growth factor (HB-EGF): analysis of O-glycosylation sites and properties.
Growth factors (Chur, Switzerland) 2001;19(2):127-43.
2000: Uzumcu M; Homsi M F; Ball D K; Coskun S; Jaroudi K; Hollanders J M; Brigstock D R
Localization of connective tissue growth factor in human uterine tissues.
Molecular human reproduction 2000;6(12):1093-8.
2000: Moussad E E; Brigstock D R
Connective tissue growth factor: what's in a name?
Molecular genetics and metabolism 2000;71(1-2):276-92.
1999: Brigstock D R
The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family.
Endocrine reviews 1999;20(2):189-206.
1999: Surveyor G A; Brigstock D R
Immunohistochemical localization of connective tissue growth factor (CTGF) in the mouse embryo between days 7.5 and 14.5 of gestation.
Growth factors (Chur, Switzerland) 1999;17(2):115-24.
1999: Harding P A; Davis-Fleischer K M; Crissman-Combs M A; Miller M T; Brigstock D R; Besner G E
Induction of anchorage independent growth by heparin-binding EGF-like growth factor (HB-EGF).
Growth factors (Chur, Switzerland) 1999;17(1):49-61.
1998: Surveyor G A; Wilson A K; Brigstock D R
Localization of connective tissue growth factor during the period of embryo implantation in the mouse.
Biology of reproduction 1998;59(5):1207-13.
1998: Ball D K; Surveyor G A; Diehl J R; Steffen C L; Uzumcu M; Mirando M A; Brigstock D R
Characterization of 16- to 20-kilodalton (kDa) connective tissue growth factors (CTGFs) and demonstration of proteolytic activity for 38-kDa CTGF in pig uterine luminal flushings.
Biology of reproduction 1998;59(4):828-35.
1998: Uzumcu M; Brigstock D R; Lin Y C
Partial purification and characterization of two non-FSH steroid-modulating factors in rat thymic epithelial cell-conditioned medium (TCM).
Domestic animal endocrinology 1998;15(3):155-68.
1998: Harding P A; Surveyor G A; Brigstock D R
Characterization of pig connective tissue growth factor (CTGF) cDNA, mRNA and protein from uterine tissue.
DNA sequence : the journal of DNA sequencing and mapping 1998;8(6):385-90.
1998: Steffen C L; Ball-Mirth D K; Harding P A; Bhattacharyya N; Pillai S; Brigstock D R
Characterization of cell-associated and soluble forms of connective tissue growth factor (CTGF) produced by fibroblast cells in vitro.
Growth factors (Chur, Switzerland) 1998;15(3):199-213.
1997: Downing M T; Brigstock D R; Luquette M H; Crissman-Combs M; Besner G E
Immunohistochemical localization of heparin-binding epidermal growth factor-like growth factor in normal skin and skin cancers.
The Histochemical journal 1997;29(10):735-44.
1997: Brigstock D R; Steffen C L; Kim G Y; Vegunta R K; Diehl J R; Harding P A
Purification and characterization of novel heparin-binding growth factors in uterine secretory fluids. Identification as heparin-regulated Mr 10,000 forms of connective tissue growth factor.
The Journal of biological chemistry 1997;272(32):20275-82.
1996: Brigstock D R; Kim G Y; Steffen C L; Liu A; Vegunta R K; Ismail N H
High molecular mass forms of epidermal growth factor in pig uterine secretions.
Journal of reproduction and fertility 1996;108(2):313-20.
1996: Davis K M; Brigstock D R; Johnson P R; Crissman-Combs M A; McCarthy D W; Downing M T; Besner G E
Production of glycosylated heparin-binding EGF-like growth factor in HeLa cells using vaccinia virus.
Protein expression and purification 1996;8(1):57-67.
1996: Harding P A; Brigstock D R; Shen L; Crissman-Combs M A; Besner G E
Characterization of the gene encoding murine heparin-binding epidermal growth factor-like growth factor.
Gene 1996;169(2):291-2.
1996: McCarthy D W; Downing M T; Brigstock D R; Luquette M H; Brown K D; Abad M S; Besner G E
Production of heparin-binding epidermal growth factor-like growth factor (HB-EGF) at sites of thermal injury in pediatric patients.
The Journal of investigative dermatology 1996;106(1):49-56.
1996: Brigstock D R; Kim G Y; Steffen C L
Pig uterine luminal fluid contains the developmentally regulated neurotrophic factor, pleiotrophin.
The Journal of endocrinology 1996;148(1):103-11.
1995: Vegunta R K; Cooney D R; Downing M T; Besner G E; Brigstock D R
Unique protein expression by the TBJ clonal derivative of C1300 murine neuroblastoma.
Journal of pediatric surgery 1995;30(12):1668-72.
1995: Kim G Y; Besner G E; Steffen C L; McCarthy D W; Downing M T; Luquette M H; Abad M S; Brigstock D R
Purification of heparin-binding epidermal growth factor-like growth factor from pig uterine luminal flushings, and its production by endometrial tissues.
Biology of reproduction 1995;52(3):561-71.
1992: Besner G E; Whelton D; Crissman-Combs M A; Steffen C L; Kim G Y; Brigstock D R
Interaction of heparin-binding EGF-like growth factor (HB-EGF) with the epidermal growth factor receptor: modulation by heparin, heparinase, or synthetic heparin-binding HB-EGF fragments.
Growth factors (Chur, Switzerland) 1992;7(4):289-96.

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