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Feng-Chun Yang

Research Profile

Living Beings

Chemicals & Drugs

Disorders

Physiology

Anatomy

Genes & Molecular Sequences

Genes, Neurofibromatosis 1

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Publications

TOP 3
Karl Staser; Feng-Chun Yang; Matthew A Shew; D Wade Clapp; Elizabeth G Michels; Muithi M Mwanthi; Su-Jung Park
A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells.
Kent A Robertson; Marcie R Sherman; Karl W Staser; Jeffrey B Travers; Terry A Vik; Laurence E Walsh; Feng-Chun Yang; Menggang Yu; Mervyn D Cohen; James M Croop; Cynthia J Davis; Scott C Denne; Mary K Edwards-Brown; James W Fletcher; Cynthia M Hingtgen; Chang Y Ho; Gary D Hutchins; David A Ingram; Melissa W Lee; Lucy C Miller; Grzegorz Nalepa; Luis F Parada; Kamnesh R Pradhan; Daniel C Bowers; D Wade Clapp
Imatinib mesylate for plexiform neurofibromas in patients with neurofibromatosis type 1: a phase 2 trial.
Feng-Chun Yang; Karl Staser; D Wade Clapp
The plexiform neurofibroma microenvironment.

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All Publications

2013: Karl Staser; Feng-Chun Yang; Matthew A Shew; D Wade Clapp; Elizabeth G Michels; Muithi M Mwanthi; Su-Jung Park
A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells.
Experimental hematology 2013;41(1):56-66.e2.
2012: Kent A Robertson; Marcie R Sherman; Karl W Staser; Jeffrey B Travers; Terry A Vik; Laurence E Walsh; Feng-Chun Yang; Menggang Yu; Mervyn D Cohen; James M Croop; Cynthia J Davis; Scott C Denne; Mary K Edwards-Brown; James W Fletcher; Cynthia M Hingtgen; Chang Y Ho; Gary D Hutchins; David A Ingram; Melissa W Lee; Lucy C Miller; Grzegorz Nalepa; Luis F Parada; Kamnesh R Pradhan; Daniel C Bowers; D Wade Clapp
Imatinib mesylate for plexiform neurofibromas in patients with neurofibromatosis type 1: a phase 2 trial.
The lancet oncology 2012;13(12):1218-24.
2012: Feng-Chun Yang; Karl Staser; D Wade Clapp
The plexiform neurofibroma microenvironment.
Cancer microenvironment : official journal of the International Cancer Microenvironment Society 2012;5(3):307-10.
2012: Yongzheng He; Li Jiang; Xianqi Li; Khalid S Mohammad; Steven D Rhodes; Naoyuki Takahashi; Xiaohua Wu; Mingjiang Xu; Shi Chen; Theresa A Guise; Xianlin Yang; Jin Yuan; Feng-Chun Yang
c-Fms signaling mediates neurofibromatosis Type-1 osteoclast gain-in-functions.
PloS one 2012;7(11):e46900.
2012: Joseph P Bidwell; Marta B Alvarez; Paul Childress; Yongzheng He; Mark Hood; Melissa A Kacena; Fredrick M Pavalko; Feng-Chun Yang
Nmp4/CIZ closes the parathyroid hormone anabolic window.
Critical reviews in eukaryotic gene expression 2012;22(3):205-18.
2011: Zhenyun Yang; Fuqin Yin; Menggang Yu; Mia Chen; Tirajeh Saadatzadeh; Sarah A Sitarski; Feng-Chun Yang; Rebecca J Chan
Genetic disruption of the scaffolding protein, Kinase Suppressor of Ras 1 (KSR1), differentially regulates GM-CSF-stimulated hyperproliferation in hematopoietic progenitors expressing activating PTPN11 mutants D61Y and E76K.
Leukemia research 2011;35(7):961-4.
2011: Xiaohua Wu; Shi Chen; Selina A Orlando; Jin Yuan; Edward T Kim; Veerendra Munugalavadla; Raghuveer S Mali; Reuben Kapur; Feng-Chun Yang
p85alpha regulates osteoblast differentiation by cross-talking with the MAPK pathway.
The Journal of biological chemistry 2011;286(15):13512-21.
2011: Xiaohua Wu; Xianlin Yang; Shi Chen; D Wade Clapp; Simon J Conway; Theresa A Guise; Yongzheng He; Li Jiang; Xiaohong Li; Khalid S Mohammad; Grzegorz Nalepa; Steven D Rhodes; Alexander G Robling; Paige Snider; Feng-Chun Yang
The haploinsufficient hematopoietic microenvironment is critical to the pathological fracture repair in murine models of neurofibromatosis type 1.
PloS one 2011;6(9):e24917.
2010: Shi Chen; Sarah Burgin; Andrew McDaniel; Xiaohong Li; Jin Yuan; Mia Chen; Waleed Khalaf; D Wade Clapp; Feng-Chun Yang
Nf1-/- Schwann cell-conditioned medium modulates mast cell degranulation by c-Kit-mediated hyperactivation of phosphatidylinositol 3-kinase.
The American journal of pathology 2010;177(6):3125-32.
2010: Todd D Nebesio; Shi Chen; Feng-Chun Yang
What accounts for the variable responses to progesterone on Schwann cells from mice and humans-the species-specific influence or the paracrine effects from the tumor microenvironment?
Cancer biology & therapy 2010;10(11):1077-8.
2010: Eric A Benson; Mark G Goebl; Feng-Chun Yang; Reuben Kapur; Jeanette McClintick; Sonal Sanghani; D Wade Clapp; Maureen A Harrington
Loss of SIMPL compromises TNF-alpha-dependent survival of hematopoietic progenitors.
Experimental hematology 2010;38(2):71-81.
2009: Huijie Li; Yaling Liu; Qi Zhang; Yongmin Jing; Shi Chen; Zhaohui Song; Jincheng Yan; Yan Li; Xiaohua Wu; Xianghong Zhang; Yingze Zhang; Jamie Case; Menggang Yu; David A Ingram; Feng-Chun Yang
Ras dependent paracrine secretion of osteopontin by Nf1+/- osteoblasts promote osteoclast activation in a neurofibromatosis type I murine model.
Pediatric research 2009;65(6):613-8.
2009: Michael L Goodman; Shi Chen; Feng-Chun Yang; Rebecca J Chan
Novel method of murine embryonic stem cell-derived osteoclast development.
Stem cells and development 2009;18(1):195-200.
2008: Veerendra Munugalavadla; Sasidhar Vemula; Emily Catherine Sims; Subha Krishnan; Shi Chen; Jincheng Yan; Huijie Li; Paul J Niziolek; Clifford M Takemoto; Alexander G Robling; Feng-Chun Yang; Reuben Kapur
The p85alpha subunit of class IA phosphatidylinositol 3-kinase regulates the expression of multiple genes involved in osteoclast maturation and migration.
Molecular and cellular biology 2008;28(23):7182-98.
2008: Feng-Chun Yang; David A Ingram; Shi Chen; Yuan Zhu; Jin Yuan; Xiaohong Li; Xianlin Yang; Scott Knowles; Whitney Horn; Yan Li; Shaobo Zhang; Yanzhu Yang; Saeed T Vakili; Menggang Yu; Dennis Burns; Kent Robertson; Gary Hutchins; Luis F Parada; D Wade Clapp
Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrow.
Cell 2008;135(3):437-48.
2008: Jincheng Yan; Shi Chen; Yingze Zhang; Xiaohong Li; Yan Li; Xiaohua Wu; Jin Yuan; Alexander G Robling; Reuben Kapur; Reuben Karpur; Rebecca J Chan; Feng-Chun Yang
Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1.
Human molecular genetics 2008;17(7):936-48.
2007: Binghui Li; Nan Jia; David L Waning; Feng-Chun Yang; Laura S Haneline; Kristin T Chun
Cul4A is required for hematopoietic stem-cell engraftment and self-renewal.
Blood 2007;110(7):2704-7.
2007: Todd D Nebesio; Wenyu Ming; Shi Chen; Travis Clegg; Jin Yuan; Yanzhu Yang; Selina A Estwick; Yan Li; Xiaohong Li; Cynthia M Hingtgen; Feng-Chun Yang
Neurofibromin-deficient Schwann cells have increased lysophosphatidic acid dependent survival and migration-implications for increased neurofibroma formation during pregnancy.
Glia 2007;55(5):527-36.
2007: Waleed Khalaf; Feng-Chun Yang; Shi Chen; Hilary White; Waylan Bessler; David A Ingram; D Wade Clapp
K-ras is critical for modulating multiple c-kit-mediated cellular functions in wild-type and Nf1+/- mast cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(4):2527-34.
2006: Yue Si; Samantha L M Ciccone; Feng-Chun Yang; Jin Yuan; Daisy Zeng; Shi Chen; Henri J van de Vrugt; John K Critser; Fré Arwert; Laura S Haneline; D Wade Clapp
Continuous in vivo infusion of interferon-gamma (IFN-gamma) enhances engraftment of syngeneic wild-type cells in Fanca-/- and Fancg-/- mice.
Blood 2006;108(13):4283-7.
2006: Feng-Chun Yang; Shi Chen; Alexander G Robling; Xijie Yu; Todd D Nebesio; Jincheng Yan; Trent Morgan; Xiaohong Li; Jin Yuan; Janet Hock; David A Ingram; D Wade Clapp
Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions.
The Journal of clinical investigation 2006;116(11):2880-91.
2006: Xiaohua Wu; Selina A Estwick; Shi Chen; Menggang Yu; Wenyu Ming; Todd D Nebesio; Yan Li; Jin Yuan; Reuben Kapur; David Ingram; Mervin C Yoder; Feng-Chun Yang
Neurofibromin plays a critical role in modulating osteoblast differentiation of mesenchymal stem/progenitor cells.
Human molecular genetics 2006;15(19):2837-45.
2006: Feng-Chun Yang; Shi Chen; Travis Clegg; Xiaohong Li; Trent Morgan; Selina A Estwick; Jin Yuan; Waleed Khalaf; Sarah Burgin; Jeff Travers; Luis F Parada; David A Ingram; D Wade Clapp
Nf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-beta signaling.
Human molecular genetics 2006;15(16):2421-37.
2006: Amy M Munchhof; Fang Li; Hilary A White; Laura E Mead; Theresa R Krier; Amy Fenoglio; Xiaohong Li; Jin Yuan; Feng-Chun Yang; David A Ingram
Neurofibroma-associated growth factors activate a distinct signaling network to alter the function of neurofibromin-deficient endothelial cells.
Human molecular genetics 2006;15(11):1858-69.
2006: Fang Li; Amy M Munchhof; Hilary A White; Laura E Mead; Theresa R Krier; Amy Fenoglio; Shi Chen; Xiaohua Wu; Shanbao Cai; Feng-Chun Yang; David A Ingram
Neurofibromin is a novel regulator of RAS-induced signals in primary vascular smooth muscle cells.
Human molecular genetics 2006;15(11):1921-30.
2006: Laura S Haneline; Hilary White; Feng-Chun Yang; Shi Chen; Christie M Orschell; Reuben Kapur; David A Ingram
Genetic reduction of class IA PI-3 kinase activity alters fetal hematopoiesis and competitive repopulating ability of hematopoietic stem cells in vivo.
Blood 2006;107(4):1375-82.
2005: Xiaxin Li; Michelle M Le Beau; Samantha L M Ciccone; Feng-Chun Yang; Brian Freie; Shi Chen; Jin Yuan; Ping Hong; Attilio Orazi; Laura S Haneline; D Wade Clapp
Ex vivo culture of Fancc-/- stem/progenitor cells predisposes cells to undergo apoptosis, and surviving stem/progenitor cells display cytogenetic abnormalities and an increased risk of malignancy.
Blood 2005;105(9):3465-71.
2003: Feng-Chun Yang; David A Ingram; Shi Chen; Cynthia M Hingtgen; Nancy Ratner; Kelly R Monk; Travis Clegg; Hilary White; Laura E Mead; Mary Jo Wenning; David A Williams; Reuben Kapur; Simon J Atkinson; D Wade Clapp
Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells.
The Journal of clinical investigation 2003;112(12):1851-61.
2003: Hannah Huddleston; Bailin Tan; Feng-Chun Yang; Hilary White; Mary Jo Wenning; Attilio Orazi; Mervin C Yoder; Reuben Kapur; David A Ingram
Functional p85alpha gene is required for normal murine fetal erythropoiesis.
Blood 2003;102(1):142-5.
2003: Binghui Li; Feng-Chun Yang; D Wade Clapp; Kristin T Chun
Enforced expression of CUL-4A interferes with granulocytic differentiation and exit from the cell cycle.
Blood 2003;101(5):1769-76.
2002: David A Ingram; Lei Zhang; Jennifer McCarthy; Mary Jo Wenning; Lucy Fisher; Feng-Chun Yang; D Wade Clapp; Reuben Kapur
Lymphoproliferative defects in mice lacking the expression of neurofibromin: functional and biochemical consequences of Nf1 deficiency in T-cell development and function.
Blood 2002;100(10):3656-62.
2002: Ben A Croker; Emanuela Handman; John D Hayball; Tracey M Baldwin; Valentina Voigt; Leonie A Cluse; Feng-Chun Yang; David A Williams; Andrew W Roberts
Rac2-deficient mice display perturbed T-cell distribution and chemotaxis, but only minor abnormalities in T(H)1 responses.
Immunology and cell biology 2002;80(3):231-40.
2002: Ben A Croker; David M Tarlinton; Leonie A Cluse; Alana J Tuxen; Amanda Light; Feng-Chun Yang; David A Williams; Andrew W Roberts
The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(7):3376-86.
2001: Feng-Chun Yang; Simon J Atkinson; Yi Gu; Jovencio Borneo; Andrew W Roberts; Y Zheng; J Pennington; David A Williams
Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(10):5614-8.
2000: Feng-Chun Yang; Reuben Kapur; AJ King; W Tao; Chaekyun Kim; Jovencio Borneo; Robert Breese; M Marshall; Mary C Dinauer; David A Williams
Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells.
Immunity 2000;12(5):557-68.
2000: David A Ingram; Feng-Chun Yang; Jeff Travers; Mary Jo Wenning; Kelly K Hiatt; S New; Antoinette F Hood; Kevin Shannon; David A Williams; D Wade Clapp
Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo.
The Journal of experimental medicine 2000;191(1):181-8.