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Margaret Brimble

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Geoffrey M Williams; Garth J S Cooper; Kathryn Lee; Lynda Whiting; Margaret A Brimble
Synthesis of the IGF-II-like hormone vesiculin using regioselective formation of disulfide bonds.
Stefanie Papst; Moritz J Banholzer; Margaret A Brimble; Soshan Cheong; David E Williams; Richard D Tilley
One-pot synthesis of water soluble iron nanoparticles using rationally-designed peptides and ligand release.
Briar J Naysmith; Margaret A Brimble
Synthesis of the Griseusin B Framework via a One-Pot Annulation-Methylation-Double Deprotection-Spirocyclization Sequence.

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All Publications

2013: Geoffrey M Williams; Garth J S Cooper; Kathryn Lee; Lynda Whiting; Margaret A Brimble
Synthesis of the IGF-II-like hormone vesiculin using regioselective formation of disulfide bonds.
Organic & biomolecular chemistry 2013;11(19):3145-50.
2013: Stefanie Papst; Moritz J Banholzer; Margaret A Brimble; Soshan Cheong; David E Williams; Richard D Tilley
One-pot synthesis of water soluble iron nanoparticles using rationally-designed peptides and ligand release.
Chemical communications (Cambridge, England) 2013;49(40):4540-2.
2013: Briar J Naysmith; Margaret A Brimble
Synthesis of the Griseusin B Framework via a One-Pot Annulation-Methylation-Double Deprotection-Spirocyclization Sequence.
Organic letters 2013;15(8):2006-9.
2013: Jui Thiang Brian Kueh; Kerstin Moehle; John A Robinson; Geoffrey M Williams; Bernadett Bacsa; Ka Wai Choi; Margaret A Brimble
Synthesis of a 6,6-spiroketal amino acid and its incorporation into a peptide turn sequence using solid-phase peptide synthesis.
Chemistry (Weinheim an der Bergstrasse, Germany) 2013;19(12):3807-11.
2013: U Bin Kim; Daniel P Furkert; Margaret A Brimble
Total synthesis of chaetoquadrins A-C.
Organic letters 2013;15(3):658-61.
2013: Louise A Stubbing; G Paul Savage; Margaret A Brimble
N-alkylsulfonylimines as dipolarophiles in cycloaddition reactions.
Chemistry, an Asian journal 2013;8(1):42-8.
2012: Margaret A Brimble; Isabell Haym; Jonathan Sperry; Daniel P Furkert
Synthesis of the tetracyclic core of berkelic acid using gold(I)-catalyzed hydroarylation and oxidative radical cyclizations.
Organic letters 2012;14(23):5820-3.
2012: Kuo-yuan Hung; Paul W R Harris; Margaret A Brimble
Synthesis of the peptaibol framework of the anticancer agent culicinin D: stereochemical assignment of the AHMOD moiety.
Organic letters 2012;14(22):5784-7.
2012: Tom M Woods; Garth J S Cooper; Paul W R Harris; Meder Kamalov; Margaret A Brimble
Synthesis of monolysyl advanced glycation endproducts and their incorporation into collagen model peptides.
Organic letters 2012;14(22):5740-3.
2012: Andrew D Wadsworth; Daniel P Furkert; Jonathan Sperry; Margaret A Brimble
Total synthesis of the initially reported and revised structures of the neuroprotective agent palmyrolide A.
Organic letters 2012;14(20):5374-7.
2012: Renata Kowalczyk; Maureen Watson; Margaret A Brimble; Karen E Callon; Jillian Cornish
How to blast osteoblasts? Novel dicarba analogues of amylin-(1-8) to treat osteoporosis.
Bioorganic & medicinal chemistry 2012;20(20):6011-8.
2012: Isabell Haym; Margaret A Brimble
The Kulinkovich hydroxycyclopropanation reaction in natural product synthesis.
Organic & biomolecular chemistry 2012;10(38):7649-65.
2012: Tsz-Ying Yuen; Margaret A Brimble
Total synthesis of 7',8'-dihydroaigialospirol.
Organic letters 2012;14(19):5154-7.
2012: Dong Jun Lee; Geoffrey M Williams; Sung-Hyun Yang; Margaret A Brimble
Synthesis of multivalent neoglyconjugates of MUC1 by the conjugation of carbohydrate-centered, triazole-linked glycoclusters to MUC1 peptides using click chemistry.
The Journal of organic chemistry 2012;77(17):7564-71.
2012: Stefanie Papst; Yi Yang; Margaret A Brimble; Anaïs F M Noisier; Geoffrey W Krissansen
Synthesis and biological evaluation of tyrosine modified analogues of the α4β7 integrin inhibitor biotin-R₈ERY.
Bioorganic & medicinal chemistry 2012;20(17):5139-49.
2012: Paul W R Harris; Dong Jun Lee; Margaret A Brimble
A slow gradient approach for the purification of synthetic polypeptides by reversed phase high performance liquid chromatography.
Journal of peptide science : an official publication of the European Peptide Society 2012;18(9):549-55.
2012: Jui Thiang Brian Kueh; Ka Wai Choi; Margaret A Brimble
Enantioselective synthesis of C-linked spiroacetal-triazoles as privileged natural product-like scaffolds.
Organic & biomolecular chemistry 2012;10(30):5993-6002.
2012: Katrin Schünemann; Jonathan Sperry; Ian A Wilson; Stephen Connelly; John D Fraser; Renata Kowalczyk; Margaret A Brimble
A simple solid phase, peptide-based fluorescent assay for the efficient and universal screening of HRV 3C protease inhibitors.
Bioorganic & medicinal chemistry letters 2012;22(15):5018-24.
2012: David Rennison; Sergio Bova; Maurizio Cavalli; Brian Hopkins; Olivia Laita; Darwin S Linthicum; Margaret A Brimble
Design and synthesis of prodrugs of the rat selective toxicant norbormide.
Bioorganic & medicinal chemistry 2012;20(13):3997-4011.
2012: Mazdak Radjainia; Michael Schmitz; Yu Wang; Sung H Yang; Bo Bai; Margaret A Brimble; Michael D W Griffin; Paul W R Harris; Bosheng Huang; Alok K Mitra
A highly conserved tryptophan in the N-terminal variable domain regulates disulfide bond formation and oligomeric assembly of adiponectin.
The FEBS journal 2012;279(14):2495-507.
2012: Stefanie Papst; Yi Yang; Margaret A Brimble; Anaïs Noisier; Geoffrey W Krissansen
Tyrosine modified analogues of the α4β7 integrin inhibitor biotin-R₈ERY prepared via Click Chemistry: synthesis and biological evaluation.
Bioorganic & medicinal chemistry 2012;20(8):2638-44.
2012: Renata Kowalczyk; Maureen Watson; Margaret A Brimble; Karen E Callon; Paul W R Harris; Jillian Cornish
Synthesis and evaluation of disulfide bond mimetics of amylin-(1-8) as agents to treat osteoporosis.
Bioorganic & medicinal chemistry 2012;20(8):2661-8.
2012: Katherine R Herbert; Geoffrey M Williams; Garth J S Cooper; Margaret A Brimble
Synthesis of glycosylated 5-hydroxylysine, an important amino acid present in collagen-like proteins such as adiponectin.
Organic & biomolecular chemistry 2012;10(6):1137-44.
2012: Amanda M Heapy; Geoffrey M Williams; John D Fraser; Margaret A Brimble
Synthesis of a dicarba analogue of human β-defensin-1 using a combined ring closing metathesis--native chemical ligation strategy.
Organic letters 2012;14(3):878-81.
2011: Alessandra Zulian; Justina Sileikytė; Paolo Bernardi; Sergio Bova; Margaret A Brimble; Gabriella Cargnelli; Federica Dabbeni-Sala; Brian Hopkins; Valeria Petronilli; David Rennison; Fernanda Ricchelli
The translocator protein (peripheral benzodiazepine receptor) mediates rat-selective activation of the mitochondrial permeability transition by norbormide.
Biochimica et biophysica acta 2011;1807(12):1600-5.
2011: Jack Li-Yang Chen; Margaret A Brimble
Synthesis of the bis-spiroacetal core of the antimitotic agent spirastrellolide B.
The Journal of organic chemistry 2011;76(22):9417-28.
2011: Sung Hyun Yang; Dong Jun Lee; Margaret A Brimble
Synthesis of an NDPK phosphocarrier domain peptide containing a novel triazolylalanine analogue of phosphohistidine using click chemistry.
Organic letters 2011;13(20):5604-7.
2011: Michael C McLeod; Zoe E Wilson; Margaret A Brimble
An enantioselective formal synthesis of berkelic acid.
Organic letters 2011;13(19):5382-5.
2011: Harveen Kaur; Amanda M Heapy; Margaret A Brimble
The synthesis of dehydrotryptophan and dehydrotryptophan-containing peptides.
Organic & biomolecular chemistry 2011;9(17):5897-907.
2011: Tsz-Ying Yuen; Sung-Hyun Yang; Margaret A Brimble
Total synthesis of paecilospirone.
Angewandte Chemie (International ed. in English) 2011;50(36):8350-3.
2011: Dong Jun Lee; Paul W R Harris; Margaret A Brimble
Synthesis of MUC1 Neoglycopeptides using efficient microwave-enhanced chaotrope-assisted click chemistry.
Organic & biomolecular chemistry 2011;9(5):1621-6.
2011: Kuo-yuan Hung; Paul W R Harris; Amanda M Heapy; Margaret A Brimble
Synthesis and assignment of stereochemistry of the antibacterial cyclic peptide xenematide.
Organic & biomolecular chemistry 2011;9(1):236-42.
2010: Kuo-Yuan Hung; Paul W R Harris; Margaret A Brimble
Synthesis of methyl N-Boc-(2S,4R)-4-methylpipecolate.
The Journal of organic chemistry 2010;75(24):8728-31.
2010: Stéphanie M Guéret; Daniel P Furkert; Margaret A Brimble
Synthesis of a functionalized 7,6-bicyclic spiroimine ring fragment of the spirolides.
Organic letters 2010;12(22):5226-9.
2010: Peter J Choi; Jonathan Sperry; Margaret A Brimble
Heteroatom-directed reverse Wacker oxidations. Synthesis of the reported structure of (-)-herbaric acid.
The Journal of organic chemistry 2010;75(21):7388-92.
2010: Stéphanie M Guéret; Margaret A Brimble
Spiroimine shellfish poisoning (SSP) and the spirolide family of shellfish toxins: isolation, structure, biological activity and synthesis.
Natural product reports 2010;27(9):1350-66.
2010: Jonathan Sperry; Zoe E Wilson; Dominea C K Rathwell; Margaret A Brimble
Isolation, biological activity and synthesis of benzannulated spiroketal natural products.
Natural product reports 2010;27(8):1117-37.
2010: Jack Li-Yang Chen; Margaret A Brimble
Synthesis of the bis-spiroacetal C25-C40 moiety of the antimitotic agent spirastrellolide B using a bis-dithiane deprotection/spiroacetalisation sequence.
Chemical communications (Cambridge, England) 2010;46(22):3967-9.
2010: Zoe E Wilson; Margaret A Brimble
A flexible asymmetric synthesis of the tetracyclic core of berkelic acid using a Horner-Wadsworth-Emmons/oxa-Michael cascade.
Organic & biomolecular chemistry 2010;8(6):1284-6.
2010: Jonathan Sperry; Eric B J Harris; Margaret A Brimble
Total synthesis and absolute configuration of (-)-berkeleyamide A.
Organic letters 2010;12(3):420-3.
2010: Jonathan Sperry; Yen-Cheng William Liu; Margaret A Brimble
Synthesis of natural products containing spiroketals via intramolecular hydrogen abstraction.
Organic & biomolecular chemistry 2010;8(1):29-38.
2010: Stéphanie M Guéret; Peter D W Boyd; Margaret A Brimble
(1R,6R,13R,18R)-(Z,Z)-1,18-Bis[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-3,16-dimethyl-ene-8,20-diaza-dispiro-[5.6.5.6]tetra-cosa-7,19-diene.
Acta crystallographica. Section E, Structure reports online 2010;66(Pt 7):o1778-9.
2010: Paul W R Harris; Margaret A Brimble
Toward the total chemical synthesis of the cancer protein NY-ESO-1.
Biopolymers 2010;94(4):542-50.
2009: Patrick D O'Connor; Michael G Marino; Stéphanie M Guéret; Margaret A Brimble
Synthesis and reactivity of beta-methoxymethyl enecarbamates.
The Journal of organic chemistry 2009;74(22):8893-6.
2009: Dong Jun Lee; Kalyaneswar Mandal; Paul W R Harris; Margaret A Brimble; Stephen B H Kent
A one-pot approach to neoglycopeptides using orthogonal native chemical ligation and click chemistry.
Organic letters 2009;11(22):5270-3.
2009: Jonathan Sperry; Isabel Lorenzo-Castrillejo; Margaret A Brimble; Felix Machín
Pyranonaphthoquinone derivatives of eleutherin, ventiloquinone L, thysanone and nanaomycin A possessing a diverse topoisomerase II inhibition and cytotoxicity spectrum.
Bioorganic & medicinal chemistry 2009;17(20):7131-7.
2009: Jonathan Sperry; Jimmy J P Sejberg; Frank M Stiemke; Margaret A Brimble
Biomimetic studies towards the cardinalins: synthesis of (+)-ventiloquinone L and an unusual dimerisation.
Organic & biomolecular chemistry 2009;7(12):2599-603.
2009: Nicole Miller; Geoffrey M Williams; Margaret A Brimble
Synthesis of fish antifreeze neoglycopeptides using microwave-assisted "click chemistry".
Organic letters 2009;11(11):2409-12.
2009: Ka Wai Choi; Margaret A Brimble
Synthesis of spiroacetal-nucleosides as privileged natural product-like scaffolds.
Organic & biomolecular chemistry 2009;7(7):1424-36.
2009: Sarah Carley; Margaret A Brimble
A novel approach to the CDE ring system of pectenotoxin-4 triggered by VO(acac)(2)-induced epoxy-acetalization.
Organic letters 2009;11(3):563-6.
2009: Shanthinie Ravindran; David Rennison; Sergio Bova; Margaret A Brimble; Brian Hopkins; Malcolm D Tingle
In vitro metabolism of norbormide in rat, mouse and guinea pig liver preparations.
Environmental toxicology and pharmacology 2009;27(1):144-8.
2009: Dominea C K Rathwell; Sung-Hyun Yang; Kit Y Tsang; Margaret A Brimble
An efficient formal synthesis of the human telomerase inhibitor (+/-)-gamma-rubromycin.
Angewandte Chemie (International ed. in English) 2009;48(43):7996-8000.
2009: Renata Kowalczyk; Margaret A Brimble; Rod Dunbar
Synthesis of mannosylated glycopeptides as components for synthetic vaccines.
Advances in experimental medicine and biology 2009;611():351-2.
2009: Zoe E Wilson; Margaret A Brimble
Molecules derived from the extremes of life.
Natural product reports 2009;26(1):44-71.
2008: Jonathan Sperry; Jennifer S Gibson; Jimmy J P Sejberg; Margaret A Brimble
Enantioselective synthesis of the dimeric pyranonaphthoquinone core of the cardinalins using a late-stage homocoupling strategy.
Organic & biomolecular chemistry 2008;6(22):4261-70.
2008: Fiona J Radcliff; John D Fraser; Zoe E Wilson; Amanda M Heapy; James E Robinson; Christina J Bryant; Christopher L Flowers; Margaret A Brimble
Anti-Helicobacter pylori activity of derivatives of the phthalide-containing antibacterial agents spirolaxine methyl ether, CJ-12,954, CJ-13,013, CJ-13,102, CJ-13,104, CJ-13,108 and CJ-13,015.
Bioorganic & medicinal chemistry 2008;16(11):6179-85.
2008: Jonathan Sperry; bachu prabhakar; Margaret A Brimble
Pyranonaphthoquinones--isolation, biological activity and synthesis.
Natural product reports 2008;25(2):376-400.
2008: Margaret A Brimble; Renata Kowalczyk; Paul W R Harris; P Rod Dunbar; Victoria J Muir
Synthesis of fluorescein-labelled O-mannosylated peptides as components for synthetic vaccines: comparison of two synthetic strategies.
Organic & biomolecular chemistry 2008;6(1):112-21.
2008: Sok Teng Tong; David Barker; Ka Wai Choi; Peter D W Boyd; Margaret A Brimble
(±)-Cyclo-hexane-1,2-diyl bis-(4-nitro-benzoate).
Acta crystallographica. Section E, Structure reports online 2008;64(Pt 11):o2174.
2008: Daryl Crimmins; Ka Wai Choi; Peter D W Boyd; Margaret A Brimble
(±)-2'-Phenyl-cyclo-hexa-nespiro-4'-(aze-pano[1,2-b]isoxazolidine).
Acta crystallographica. Section E, Structure reports online 2008;64(Pt 8):o1535.
2008: Jimmy J P Sejberg; Jonathan Sperry; Ka Wai Choi; Peter D W Boyd; Margaret A Brimble
(1R,1'R,3S,3'S)-5,5',10,10'-Tetra-meth-oxy-1,1',3,3'-tetra-methyl-3,3',4,4'-tetra-hydro-1H,1'H-8,8'-bi[benzo[g]isochromene].
Acta crystallographica. Section E, Structure reports online 2008;64(Pt 4):o758.
2008: Sok Teng Tong; David Barker; Ka Wai Choi; Peter D W Boyd; Margaret A Brimble
(±)-N-(3-Hydr-oxy-1,2-diphenyl-prop-yl)-4-methyl-benzene-sulfonamide.
Acta crystallographica. Section E, Structure reports online 2008;64(Pt 10):o1990.
2008: Dominea C K Rathwell; Kit Y Tsang; Ka Wai Choi; Peter D W Boyd; Margaret A Brimble
3-Allyl-2-hydr-oxy-5,6,8-trimethoxy-naphthalene-1,4-dione.
Acta crystallographica. Section E, Structure reports online 2008;64(Pt 10):o1929.
2008: Kirsten J Goodall; Margaret A Brimble; David Barker
1H and 13C NMR spectra of C-6 and C-9 substituted 3-azabicyclco[3.3.1]nonanes.
Magnetic resonance in chemistry : MRC 2008;46(1):75-9.
2007: Dong Jun Lee; Renata Kowalczyk; Victoria J Muir; Phillip M Rendle; Margaret A Brimble
A comparative study of different glycosylation methods for the synthesis of D-mannopyranosides of Nalpha-fluorenylmethoxycarbonyl-trans-4-hydroxy-L-proline allyl ester.
Carbohydrate research 2007;342(17):2628-34.
2007: Jian Guan; Sam Mathai; P Harris; JY Wen; R Zhang; Margaret A Brimble; Peter D Gluckman
Peripheral administration of a novel diketopiperazine, NNZ 2591, prevents brain injury and improves somatosensory-motor function following hypoxia-ischemia in adult rats.
Neuropharmacology 2007;53(6):749-62.
2007: Margaret A Brimble; Christina J Bryant
Synthesis and assignment of the absolute configuration of the anti-Helicobacter pylori agents CJ-12,954 and CJ-13,014.
Organic & biomolecular chemistry 2007;5(17):2858-66.
2007: James E Robinson; Margaret A Brimble
Synthesis of the anti-Helicobacter pylori agent (+)-spirolaxine methyl ether and the unnatural (2"S)-diastereomer.
Organic & biomolecular chemistry 2007;5(16):2572-82.
2007: Patrick D O'Connor; Margaret A Brimble
Synthesis of macrocyclic shellfish toxins containing spiroimine moieties.
Natural product reports 2007;24(4):869-85.
2007: Kirsten J Goodall; Margaret A Brimble; David Barker
1H and 13C NMR spectra of methylmaleimido- and methylsuccinimidoanthranilate esters of 1-hydroxymethyl-6-methoxy-3-azabicyclo[3.3.1]nonanes.
Magnetic resonance in chemistry : MRC 2007;45(8):695-9.
2007: Alessandra Zulian; Valeria Petronilli; Sergio Bova; Federica Dabbeni-Sala; Gabriella Cargnelli; Maurizio Cavalli; David Rennison; Jessica Stäb; Olivia Laita; Dong Jun Lee; Margaret A Brimble; Brian Hopkins; Paolo Bernardi; Fernanda Ricchelli
Assessing the molecular basis for rat-selective induction of the mitochondrial permeability transition by norbormide.
Biochimica et biophysica acta 2007;1767(7):980-8.
2007: David Rennison; Sergio Bova; Maurizio Cavalli; Fernanda Ricchelli; Alessandra Zulian; Brian Hopkins; Margaret A Brimble
Synthesis and activity studies of analogues of the rat selective toxicant norbormide.
Bioorganic & medicinal chemistry 2007;15(8):2963-74.
2006: Rosliana Halim; Margaret A Brimble
Synthetic studies towards the pectenotoxins: a review.
Organic & biomolecular chemistry 2006;4(22):4048-58.
2006: Margaret A Brimble; Christina J Bryant
Synthesis of the spiroacetal-containing anti-Helicobacter pylori agents CJ-12,954 and CJ-13,014.
Chemical communications (Cambridge, England) 2006;(43):4506-8.
2006: Kirsten J Goodall; Margaret A Brimble; David Barker
1H and 13C NMR data for C-6 substituted 3-azabicyclo[3.3.1]nonane-1-carboxylates.
Magnetic resonance in chemistry : MRC 2006;44(10):980-3.
2006: Paul W R Harris; Margaret A Brimble
Synthesis of macrocyclic analogues of the neuroprotective agent glycyl-L-prolyl-L-glutamic acid (GPE).
Organic & biomolecular chemistry 2006;4(14):2696-709.
2006: Kai Meilert; Margaret A Brimble
Synthesis of the bis-spiroacetal moiety of the shellfish toxins spirolides B and D using an iterative oxidative radical cyclization strategy.
Organic & biomolecular chemistry 2006;4(11):2184-92.
2006: Margaret A Brimble; Mark S Levi
A review of agents patented for their neuroprotective properties.
Recent patents on CNS drug discovery 2006;1(2):139-46.
2006: Rosliana Halim; Margaret A Brimble; Jörn Merten
Synthesis of the ABC tricyclic fragment of the pectenotoxins via stereocontrolled cyclization of a gamma-hydroxyepoxide appended to the AB spiroacetal unit.
Organic & biomolecular chemistry 2006;4(7):1387-99.
2005: Michael Dragunow; Patrick Holland; Veronica Beuzenberg; Margaret A Brimble; Rachel Cameron; Michael Trzoss; Doug Mountfort
Investigations into the cellular actions of the shellfish toxin gymnodimine and analogues.
Environmental toxicology and pharmacology 2005;20(2):305-12.
2005: Kai Meilert; Margaret A Brimble
Synthesis of the bis-spiroacetal moiety of spirolides B and D.
Organic letters 2005;7(16):3497-500.
2005: David Barker; Diana H-S Lin; Jane E Carland; Cindy P-Y Chu; Mary Chebib; Margaret A Brimble; G Paul Savage; Malcolm D McLeod
Methyllycaconitine analogues have mixed antagonist effects at nicotinic acetylcholine receptors.
Bioorganic & medicinal chemistry 2005;13(14):4565-75.
2005: Rosliana Halim; Margaret A Brimble; Jörn Merten
Synthesis of the ABC fragment of the pectenotoxins.
Organic letters 2005;7(13):2659-62.
2005: James E Robinson; Margaret A Brimble
The first enantioselective total synthesis of the anti-Helicobacter pylori agent (+)-spirolaxine methyl ether.
Chemical communications (Cambridge, England) 2005;(12):1560-2.
2005: Michelle Y H Lai; Margaret A Brimble; David J Callis; Paul W R Harris; Mark S Levi; Frank Sieg
Synthesis and pharmacological evaluation of glycine-modified analogues of the neuroprotective agent glycyl-L-prolyl-L-glutamic acid (GPE).
Bioorganic & medicinal chemistry 2005;13(2):533-48.
2005: Margaret A Brimble; Nicholas S Trotter; Paul W R Harris; Frank Sieg
Synthesis and pharmacological evaluation of side chain modified glutamic acid analogues of the neuroprotective agent glycyl-L-prolyl-L-glutamic acid (GPE).
Bioorganic & medicinal chemistry 2005;13(2):519-32.
2005: Nicholas S Trotter; Margaret A Brimble; Paul W R Harris; David J Callis; Frank Sieg
Synthesis and neuroprotective activity of analogues of glycyl-L-prolyl-L-glutamic acid (GPE) modified at the alpha-carboxylic acid.
Bioorganic & medicinal chemistry 2005;13(2):501-17.
2004: Margaret A Brimble; Daniel P Furkert
Synthesis of the 1,6,8-trioxadispiro[4.1.5.2]tetradec-11-ene ring system present in the spirolide family of shellfish toxins and its conversion into a 1,6,8-trioxadispiro[4.1.5.2]-tetradec-9-en-12-ol via base-induced rearrangement of an epoxide.
Organic & biomolecular chemistry 2004;2(24):3573-83.
2004: M S Levi; Margaret A Brimble
A review of neuroprotective agents.
Current medicinal chemistry 2004;11(18):2383-97.
2004: David Barker; Margaret A Brimble; Malcolm D McLeod; G Paul Savage
Synthesis of tricyclic analogues of methyllycaconitine using ring closing metathesis to append a B ring to an AE azabicyclic fragment.
Organic & biomolecular chemistry 2004;2(11):1659-69.
2004: Peter J Steel; Margaret A Brimble; Brian Hopkins; David Rennison
Two stereoisomers of the rat toxicant norbormide.
Acta crystallographica. Section C, Crystal structure communications 2004;60(Pt 5):o374-6.
2004: Margaret A Brimble
Radical oxidative cyclization of spiroacetals to bis-spiroacetals: an overview.
Molecules (Basel, Switzerland) 2004;9(6):394-404.
2003: Margaret A Brimble; Michelle Y H Lai
Synthesis of regioisomeric analogues of crisamicin A.
Organic & biomolecular chemistry 2003;1(23):4227-34.
2003: Kit Y Tsang; Margaret A Brimble; John B Bremner
Use of a sonogashira-acetylide coupling strategy for the synthesis of the aromatic spiroketal skeleton of gamma-rubromycin.
Organic letters 2003;5(23):4425-7.
2003: Margaret A Brimble; Michelle Y H Lai
Suzuki-Miyaura homocoupling of naphthyl triflates using bis(pinacolato)diboron: approaches to the biaryl skeleton of crisamicin A.
Organic & biomolecular chemistry 2003;1(12):2084-95.
2003: Paul W R Harris; Margaret A Brimble; Peter D Gluckman
Synthesis of cyclic proline-containing peptides via ring-closing metathesis.
Organic letters 2003;5(11):1847-50.
2003: Margaret A Brimble; Roger M Davey; Malcolm D McLeod; Maureen Murphy
Synthesis of 3-azido-2,3,6-trideoxy-beta-D-arabino-hexopyranosyl pyranonaphthoquinone analogues of medermycin.
Organic & biomolecular chemistry 2003;1(10):1690-700.
2002: Daniel P Furkert; Margaret A Brimble
Synthesis of the C10-C22 bis-spiroacetal domain of spirolides B and D via iterative oxidative radical cyclization.
Organic letters 2002;4(21):3655-8.
2001: P Allen ; Margaret A Brimble; Peter Turner
Polyether antibiotic CP44,161.
Acta crystallographica. Section C, Crystal structure communications 2001;57(Pt 1):95-6.
1999: Margaret A Brimble; L J Duncalf; M R Nairn
Pyranonaphthoquinone antibiotics--isolation, structure and biological activity.
Natural product reports 1999;16(3):267-81.