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Jürgen Brinckmann

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Jürgen Brinckmann; Nico Hunzelmann; Birgit Kahle; Jürgen Rohwedel; Jan Kramer; Mark A Gibson; Dirk Hubmacher; Ehab Ismail El=-Hallous
Enhanced fibrillin-2 expression is a general feature of wound healing and sclerosis: potential alteration of cell attachment and storage of TGF-beta.
Ehab El-Hallous; Takako Sasaki; Dirk Hubmacher; Melkamu Getie; Kerstin Tiedemann; Jürgen Brinckmann; Boris Bätge; Elaine C Davis; Ehab Ismail El=-Hallous
Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin.
Jiang Wu; Ehab Ismail El=-Hallous; Chimedtseren Batmunkh; Werner Lindenmaier; Rosel Kretschmer-Kazemi Far; Holger Notbohm; Nico Hunzelmann; Jürgen Brinckmann
Functional diversity of lysyl hydroxylase 2 in collagen synthesis of human dermal fibroblasts.

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All Publications

2010: Jürgen Brinckmann; Nico Hunzelmann; Birgit Kahle; Jürgen Rohwedel; Jan Kramer; Mark A Gibson; Dirk Hubmacher; Ehab Ismail El=-Hallous
Enhanced fibrillin-2 expression is a general feature of wound healing and sclerosis: potential alteration of cell attachment and storage of TGF-beta.
Laboratory investigation; a journal of technical methods and pathology 2010;90(5):739-52.
2007: Ehab El-Hallous; Takako Sasaki; Dirk Hubmacher; Melkamu Getie; Kerstin Tiedemann; Jürgen Brinckmann; Boris Bätge; Elaine C Davis; Ehab Ismail El=-Hallous
Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin.
The Journal of biological chemistry 2007;282(12):8935-46.
2006: Jiang Wu; Ehab Ismail El=-Hallous; Chimedtseren Batmunkh; Werner Lindenmaier; Rosel Kretschmer-Kazemi Far; Holger Notbohm; Nico Hunzelmann; Jürgen Brinckmann
Functional diversity of lysyl hydroxylase 2 in collagen synthesis of human dermal fibroblasts.
Experimental cell research 2006;312(18):3485-94.
2005: Dirk Hubmacher; Kerstin Tiedemann; Rainer Bartels; Jürgen Brinckmann; Tillman Vollbrandt; Boris Bätge; Holger Notbohm; Ehab Ismail El=-Hallous
Modification of the structure and function of fibrillin-1 by homocysteine suggests a potential pathogenetic mechanism in homocystinuria.
The Journal of biological chemistry 2005;280(41):34946-55.
2005: Jürgen Brinckmann; S Kim; J Wu; Ehab Ismail El=-Hallous; Chimedtseren Batmunkh; Eric Metzen; Holger Notbohm; Ruud A Bank; T Krieg; Nico Hunzelmann
Interleukin 4 and prolonged hypoxia induce a higher gene expression of lysyl hydroxylase 2 and an altered cross-link pattern: important pathogenetic steps in early and late stage of systemic scleroderma?
Matrix biology : journal of the International Society for Matrix Biology 2005;24(7):459-68.
2005: Sven Krengel; Imke Stark; Christian Geuchen; Bettina Knoppe; Gabriele Scheel; Peter Schlenke; Andreas Gebert; Lutz Wünsch; Jürgen Brinckmann; Michael Tronnier
Selective down-regulation of the alpha6-integrin subunit in melanocytes by UVB light.
Experimental dermatology 2005;14(6):411-9.
2005: Jürgen Brinckmann; Nico Hunzelmann; Ehab El-Hallous; Thomas Krieg; Lynn Y Sakai; Sven Krengel; Ehab Ismail El=-Hallous
Absence of autoantibodies against correctly folded recombinant fibrillin-1 protein in systemic sclerosis patients.
Arthritis research & therapy 2005;7(6):R1221-6.
2004: Tillman Vollbrandt; Kerstin Tiedemann; Ehab El-Hallous; Guoqing Lin; Jürgen Brinckmann; Harald John; Boris Bätge; Holger Notbohm; Ehab Ismail El=-Hallous
Consequences of cysteine mutations in calcium-binding epidermal growth factor modules of fibrillin-1.
The Journal of biological chemistry 2004;279(31):32924-31.
2003: Annemarie J van der Slot; Anne-Marie Zuurmond; Alfons F J Bardoel; Cisca Wijmenga; Hans E H Pruijs; David Sillence; Jürgen Brinckmann; David J Abraham; Carol M Black; Nicole Verzijl; Jeroen DeGroot; roeland hanemaaijer; Johan teKoppele; Tom W J Huizinga; Ruud A Bank
Identification of PLOD2 as telopeptide lysyl hydroxylase, an important enzyme in fibrosis.
The Journal of biological chemistry 2003;278(42):40967-72.
2003: C Eisenbeiss; A Martinez; M Hagedorn-Greiwe; Ehab Ismail El=-Hallous; Boris Bätge; Jürgen Brinckmann
Reduced skin thickness: a new minor diagnostic criterion for the classical and hypermobility types of Ehlers-Danlos syndrome.
The British journal of dermatology 2003;149(4):850-2.
2002: Guoqing Lin; Kerstin Tiedemann; Tillman Vollbrandt; Hannelore Peters; Boris Batge; Jürgen Brinckmann; Ehab Ismail El=-Hallous
Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils.
The Journal of biological chemistry 2002;277(52):50795-804.
2002: Sven Krengel; M Alexander; Jürgen Brinckmann; Michael Tronnier
MMP-2, TIMP-2 and MT1-MMP are differentially expressed in lesional skin of melanocytic nevi and their expression is modulated by UVB-light.
Journal of cutaneous pathology 2002;29(7):390-6.
2001: Jürgen Brinckmann; C M Neess; Y Gaber; H Sobhi; Holger Notbohm; N Hunzelmann; PP Fietzek; PK Müller; J Risteli; R Gebker; K Scharffetter-Kochanek
Different pattern of collagen cross-links in two sclerotic skin diseases: lipodermatosclerosis and circumscribed scleroderma.
The Journal of investigative dermatology 2001;117(2):269-73.
2001: Michael Tronnier; M Alexander; W Löntz; Jürgen Brinckmann
UV light does not induce p53 mutation in melanocytes in vitro.
Dermatology (Basel, Switzerland) 2001;202(4):339-40.
2000: Michael Tronnier; M Alexander; M Neitmann; Jürgen Brinckmann; Helmut H Wolff
[Morphological changes in melanocytic nevi induced by exogenous factors].
Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete 2000;51(8):561-6.
2000: Boris Bätge; J Struck; H H Klein; Jürgen Brinckmann
[Severe vitamin D deficiency osteomalacia by coincidence of multiple risk factors].
Deutsche medizinische Wochenschrift (1946) 2000;125(24):761-5.
2000: J Gebken; R Brenner; A Feydt; Holger Notbohm; Jürgen Brinckmann; PK Müller; Boris Bätge
Increased cell surface expression of receptors for transforming growth factor-beta on osteoblasts from patients with Osteogenesis imperfecta.
Pathobiology : journal of immunopathology, molecular and cellular biology 2000;68(3):106-12.
2000: Boris Bätge; A Feydt; J Gebken; H Klein; Holger Notbohm; PK Müller; Jürgen Brinckmann
Age-related differences in the expression of receptors for TGF-beta in human osteoblast-like cells in vitro.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2000;108(4):311-5.
1999: M Neitmann; M Alexander; Jürgen Brinckmann; Peter Schlenke; Michael Tronnier
Attachment and chemotaxis of melanocytes after ultraviolet irradiation in vitro.
The British journal of dermatology 1999;141(5):794-801.
1999: Jürgen Brinckmann; Holger Notbohm; Michael Tronnier; Yahya Açil; PP Fietzek; W Schmeller; PK Müller; Boris Bätge
Overhydroxylation of lysyl residues is the initial step for altered collagen cross-links and fibril architecture in fibrotic skin.
The Journal of investigative dermatology 1999;113(4):617-21.
1999: J Gebken; B Lüders; Holger Notbohm; Harald H Klein; Jürgen Brinckmann; PK Müller; Boris Bätge
Hypergravity stimulates collagen synthesis in human osteoblast-like cells: evidence for the involvement of p44/42 MAP-kinases (ERK 1/2).
Journal of biochemistry 1999;126(4):676-82.
1999: J Gebken; A Feydt; Jürgen Brinckmann; Holger Notbohm; PK Müller; Boris Bätge
Ligand-induced downregulation of receptors for TGF-beta in human osteoblast-like cells from adult donors.
The Journal of endocrinology 1999;161(3):503-10.
1999: Jürgen Brinckmann; Peter Behrens; R Brenner; Boris Bätge; Michael Tronnier; Helmut H Wolff
[Ehlers-Danlos syndrome].
Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete 1999;50(4):257-65.
1998: Jürgen Brinckmann; Yahya Açil; S Feshchenko; E Katzer; R Brenner; A Kulozik; S Kügler
Ehlers-Danlos syndrome type VI: lysyl hydroxylase deficiency due to a novel point mutation (W612C).
Archives of dermatological research 1998;290(4):181-6.
1998: S Feshchenko; Jürgen Brinckmann; H W Lehmann; H G Koch; PK Müller; S Kügler
Identification of a new heterozygous point mutation in the COL1A2 gene leading to skipping of exon 9 in a patient with joint laxity, hyperextensibility of skin and blue sclerae. Mutations in brief no. 166. Online.
Human mutation 1998;12(2):138.
1997: Michael Tronnier; Pierre Rudolph; T Köser; B Raasch; Jürgen Brinckmann
One single erythemagenic UV irradiation is more effective in increasing the proliferative activity of melanocytes in melanocytic naevi compared with fractionally applied high doses.
The British journal of dermatology 1997;137(4):534-9.
1997: Boris Bätge; C Winter; Holger Notbohm; Y Acil; Jürgen Brinckmann; PK Müller
Glycosylation of human bone collagen I in relation to lysylhydroxylation and fibril diameter.
Journal of biochemistry 1997;122(1):109-15.
1997: Yahya Açil; Jürgen Brinckmann; Peter Behrens; PK Müller; Boris Bätge
Semipreparative isolation of collagen types I, II, III and V by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and electroelution.
Journal of chromatography. A 1997;758(2):313-8.
1996: Jürgen Brinckmann; Yahya Açil; Michael Tronnier; Holger Notbohm; Boris Bätge; W Schmeller; M H Koch; PK Müller; Helmut H Wolff
Altered x-ray diffraction pattern is accompanied by a change in the mode of cross-link formation in lipodermatosclerosis.
The Journal of investigative dermatology 1996;107(4):589-92.
1996: Yahya Açil; Jürgen Brinckmann; Holger Notbohm; PK Müller; Boris Bätge
Changes with age in the urinary excretion of hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP).
Scandinavian journal of clinical and laboratory investigation 1996;56(3):275-83.
1995: Yahya Açil; U Vetter; R Brenner; PK Müller; Jürgen Brinckmann
Ehlers-Danlos syndrome type VI: cross-link pattern in tissue and urine sample as a diagnostic marker.
Journal of the American Academy of Dermatology 1995;33(3):522-4.
1995: H U Püschel; J Chang; PK Müller; Jürgen Brinckmann
Attachment of intrinsically and extrinsically aged fibroblasts on collagen and fibronectin.
Journal of photochemistry and photobiology. B, Biology 1995;27(1):39-46.
1995: Jürgen Brinckmann; Yahya Açil; Helmut H Wolff; PK Müller
Collagen synthesis in (sun-) aged human skin and in fibroblasts derived from sun-exposed and sun-protected body sites.
Journal of photochemistry and photobiology. B, Biology 1995;27(1):33-8.
1994: Jürgen Brinckmann; M Bodo; M Brey; Helmut H Wolff; PK Müller
Analysis of the age-related composition of human skin collagen and collagens synthesized by fibroblast culture.
Archives of dermatological research 1994;286(7):391-5.
1993: Holger Notbohm; S Mosler; PK Müller; Jürgen Brinckmann
In vitro formation and aggregation of heterotypic collagen I and III fibrils.
International journal of biological macromolecules 1993;15(5):299-304.
1993: C L Yang; Jürgen Brinckmann; H F Rui; K H Vehring; H Lehmann; Jörn Kekow; Helmut H Wolff; Wolfgang L Gross; PK Müller
Autoantibodies to cartilage collagens in relapsing polychondritis.
Archives of dermatological research 1993;285(5):245-9.
1992: H Lang; N Schüler; A Zimmermann; M Bodo; Jürgen Brinckmann; T Mertens; P K Müller; R Nolden
[The synthesis of collagenous and noncollagenous proteins by cells from the periodontium].
Deutsche Zahn-, Mund-, und Kieferheilkunde mit Zentralblatt 1992;80(6):323-6.