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Paul Brindle

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TOP 3
David C Bedford; Paul K Brindle
Is histone acetylation the most important physiological function for CBP and p300?
Lawryn H Kasper; Mary C Thomas; Gerard P Zambetti; Paul K Brindle
Double null cells reveal that CBP and p300 are dispensable for p53 targets p21 and Mdm2 but variably required for target genes of other signaling pathways.
Lawryn H Kasper; Stephanie Lerach; Jianmin Wang; Song Wu; Trushar Jeevan; Paul K Brindle
CBP/p300 double null cells reveal effect of coactivator level and diversity on CREB transactivation.

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All Publications

2012: David C Bedford; Paul K Brindle
Is histone acetylation the most important physiological function for CBP and p300?
Aging 2012;4(4):247-55.
2011: Lawryn H Kasper; Mary C Thomas; Gerard P Zambetti; Paul K Brindle
Double null cells reveal that CBP and p300 are dispensable for p53 targets p21 and Mdm2 but variably required for target genes of other signaling pathways.
Cell cycle (Georgetown, Tex.) 2011;10(2):212-21.
2010: Lawryn H Kasper; Stephanie Lerach; Jianmin Wang; Song Wu; Trushar Jeevan; Paul K Brindle
CBP/p300 double null cells reveal effect of coactivator level and diversity on CREB transactivation.
The EMBO journal 2010;29(21):3660-72.
2010: David Bedford; Lawryn H Kasper; Tomofusa Fukuyama; Paul K Brindle
Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases.
Epigenetics : official journal of the DNA Methylation Society 2010;5(1):9-15.
2009: Tomofusa Fukuyama; Lawryn H Kasper; Fayçal Boussouar; Trushar Jeevan; Jan M A van Deursen; Paul K Brindle
Histone acetyltransferase CBP is vital to demarcate conventional and innate CD8+ T-cell development.
Molecular and cellular biology 2009;29(14):3894-904.
2007: Wu Xu; Lawryn H Kasper; Stephanie Lerach; Trushar Jeevan; Paul K Brindle
Individual CREB-target genes dictate usage of distinct cAMP-responsive coactivation mechanisms.
The EMBO journal 2007;26(12):2890-903.
2006: Wu Xu; Tomofusa Fukuyama; Paul A Ney; Demin Wang; Jerold E Rehg; Kelli Boyd; Jan M A van Deursen; Paul K Brindle
Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cells.
Blood 2006;107(11):4407-16.
2006: Lawryn H Kasper; Tomofusa Fukuyama; Michelle A Biesen; Fayçal Boussouar; Caili Tong; Antoine de Pauw; Peter J Murray; Jan M A van Deursen; Paul K Brindle
Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development.
Molecular and cellular biology 2006;26(3):789-809.
2006: Lawryn H Kasper; Paul K Brindle
Mammalian gene expression program resiliency: the roles of multiple coactivator mechanisms in hypoxia-responsive transcription.
Cell cycle (Georgetown, Tex.) 2006;5(2):142-6.
2005: Lawryn H Kasper; Fayçal Boussouar; Kelli Boyd; Wu Xu; Michelle Biesen; Jerold E Rehg; Troy A Baudino; John L Cleveland; Paul K Brindle
Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression.
The EMBO journal 2005;24(22):3846-58.
2005: Seung-Hoi Koo; Lawrence Flechner; Ling Qi; Xinmin Zhang; Robert A Screaton; Shawn Jeffries; Susan Hedrick; Wu Xu; Fayçal Boussouar; Paul K Brindle; Hiroshi Takemori; Marc Montminy
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism.
Nature 2005;437(7062):1109-11.
2004: Ningling Kang-Decker; Caili Tong; Fayçal Boussouar; Darren J Baker; Wu Xu; Alexey A Leontovich; William R Taylor; Paul K Brindle; Jan M A van Deursen
Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency.
Cancer cell 2004;5(2):177-89.
2002: Lawryn H Kasper; Fayçal Boussouar; Paul A Ney; Carl W Jackson; Jerold E Rehg; Jan M A van Deursen; Paul K Brindle
A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis.
Nature 2002;419(6908):738-43.
2001: H Nakajima; Paul K Brindle; M Handa; James N Ihle
Functional interaction of STAT5 and nuclear receptor co-repressor SMRT: implications in negative regulation of STAT5-dependent transcription.
The EMBO journal 2001;20(23):6836-44.
1999: D Parker; M Rivera; Tsaffrir Zor; A Henrion-Caude; I Radhakrishnan; A Kumar; Linda H. Shapiro; Peter Wright; Marc Montminy; Paul K Brindle
Role of secondary structure in discrimination between constitutive and inducible activators.
Molecular and cellular biology 1999;19(8):5601-7.
1999: Lawryn H Kasper; Paul K Brindle; Catherine A Schnabel; C E Pritchard; Michael L Cleary; Jan M A van Deursen
CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity.
Molecular and cellular biology 1999;19(1):764-76.
1998: C Yang; Linda H. Shapiro; M Rivera; A Kumar; Paul K Brindle
A role for CREB binding protein and p300 transcriptional coactivators in Ets-1 transactivation functions.
Molecular and cellular biology 1998;18(4):2218-29.
1996: Marc Montminy; Paul K Brindle; J Arias; K Ferreri; R Armstrong
Regulation of somatostatin gene transcription by cyclic adenosine monophosphate.
Metabolism: clinical and experimental 1996;45(8 Suppl 1):4-7.
1996: Marc Montminy; Paul K Brindle; J Arias; K Ferreri; R Armstrong
Regulation of somatostatin gene transcription by cAMP.
Advances in pharmacology (San Diego, Calif.) 1996;36():1-13.
1995: Paul K Brindle; T Nakajima; Marc Montminy
Multiple protein kinase A-regulated events are required for transcriptional induction by cAMP.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(23):10521-5.
1995: Marc Montminy; Paul K Brindle; J Arias; K Ferreri; R Armstrong
Regulation of somatostatin gene transcription by cAMP.
Ciba Foundation symposium 1995;190():7-20; discussion 20-5.
1994: J Arias; ARTHUR S ALBERTS; Paul K Brindle; Francois Claret; T Smeal; Michael Karin; James R Feramisco; Marc Montminy
Activation of cAMP and mitogen responsive genes relies on a common nuclear factor.
Nature 1994;370(6486):226-9.
1993: Paul K Brindle; S Linke; Marc Montminy
Protein-kinase-A-dependent activator in transcription factor CREB reveals new role for CREM repressors.
Nature 1993;364(6440):821-4.
1993: M Hagiwara; Paul K Brindle; A Harootunian; R Armstrong; J Rivier; W Vale; Roger Y Tsien; Marc Montminy
Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A.
Molecular and cellular biology 1993;13(8):4852-9.
1992: M Hagiwara; ARTHUR S ALBERTS; Paul K Brindle; Judy L Meinkoth; James R Feramisco; T Deng; Michael Karin; Shirish Shenolikar; Marc Montminy
Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB.
Cell 1992;70(1):105-13.
1992: Paul K Brindle; Marc Montminy
The CREB family of transcription activators.
Current opinion in genetics & development 1992;2(2):199-204.