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Paul Brindley

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Paul J Brindley; Peter J Hotez
Break Out: urogenital schistosomiasis and Schistosoma haematobium infection in the post-genomic era.
Hong You; Paul J Brindley; Wei Hu; Donald P McManus; Michael J Smout; Geoffrey N Gobert
Transcriptional responses of in vivo praziquantel exposure in schistosomes identifies a functional role for calcium signalling pathway member CamKII.
Banchob Sripa; Eimorn Mairiang; Jason Mulvenna; Michael J Smout; Jeffrey Bethony; Paul J Brindley; Thewarach Laha; Alex Loukas
The tumorigenic liver fluke Opisthorchis viverrini--multiple pathways to cancer.

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All Publications

2013: Paul J Brindley; Peter J Hotez
Break Out: urogenital schistosomiasis and Schistosoma haematobium infection in the post-genomic era.
PLoS neglected tropical diseases 2013;7(3):e1961.
2013: Hong You; Paul J Brindley; Wei Hu; Donald P McManus; Michael J Smout; Geoffrey N Gobert
Transcriptional responses of in vivo praziquantel exposure in schistosomes identifies a functional role for calcium signalling pathway member CamKII.
PLoS pathogens 2013;9(3):e1003254.
2012: Banchob Sripa; Eimorn Mairiang; Jason Mulvenna; Michael J Smout; Jeffrey Bethony; Paul J Brindley; Thewarach Laha; Alex Loukas
The tumorigenic liver fluke Opisthorchis viverrini--multiple pathways to cancer.
Trends in parasitology 2012;28(10):395-407.
2012: Raphaël Duvoisin; Nicola Harris; Clarence M Lee; Victoria H Mann; Gabriel Rinaldi; Sutas Suttiprapa; Mary A Ayuk; Paul J Brindley
Human U6 promoter drives stronger shRNA activity than its schistosome orthologue in Schistosoma mansoni and human fibrosarcoma cells.
Transgenic research 2012;21(3):511-21.
2012: Sutas Suttiprapa; Gabriel Rinaldi; Paul J Brindley
Prototypic chromatin insulator cHS4 protects retroviral transgene from silencing in Schistosoma mansoni.
Transgenic research 2012;21(3):555-66.
2012: Sutas Suttiprapa; Gabriel Rinaldi; Paul J Brindley
Genetic manipulation of schistosomes--progress with integration competent vectors.
Parasitology 2012;139(5):641-50.
2012: Paiboon Sithithaworn; Thitima Wongsaroj; Van De Nguyen; Ross H Andrews; Paul J Brindley; Song Liang; Yukifumi Nawa; Peter Odermatt; Muth Sinuon; Banchob Sripa
The current status of opisthorchiasis and clonorchiasis in the Mekong Basin.
Parasitology international 2012;61(1):10-6.
2012: Banchob Sripa; Ross Andrews; Yukifumi Nawa; Paiboon Sithithaworn; Paul J Brindley
Discovery of human opisthorchiasis: a mysterious history.
Parasitology international 2012;61(1):3-4.
2012: Gulsiri Senawong; Paul J Brindley; Thewarach Laha; Alex Loukas; Banchob Sripa
Cloning, expression, and characterization of a novel Opisthorchis viverrini calcium-binding EF-hand protein.
Parasitology international 2012;61(1):94-100.
2012: Eimorn Mairiang; Paiboon Sithithaworn; Smarn Tesana; Bandit Thinkhamrop; Jeffrey Bethony; Paul J Brindley; Sasithorn Kaewkes; Thewarach Laha; Alex Loukas; Banchob Sripa
Ultrasonography assessment of hepatobiliary abnormalities in 3359 subjects with Opisthorchis viverrini infection in endemic areas of Thailand.
Parasitology international 2012;61(1):208-11.
2012: Sutas Suttiprapa; Sopit Wongkham; Paul J Brindley; Sasithorn Kaewkes; Thewarach Laha; Alex Loukas; Pitchaya Matchimakul; Banchob Sripa
Molecular expression and enzymatic characterization of thioredoxin from the carcinogenic human liver fluke Opisthorchis viverrini.
Parasitology international 2012;61(1):101-6.
2012: Jittiyawadee Sripa; Paul J Brindley; Sasithorn Kaewkes; Alex Loukas; Banchob Sripa; Thewarach Laha
Evaluation of liver fluke recombinant cathepsin B-1 protease as a serodiagnostic antigen for human opisthorchiasis.
Parasitology international 2012;61(1):191-5.
2012: Neil D Young; Adhemar Zerlotini; Guojie Zhang; Paul J Brindley; Bronwyn E Campbell; Cinzia Cantacessi; Fangyuan Chen; Xiaodong Fang; Ross S Hall; Andreas Hofmann; Aaron R Jex; Yi Kang; Bo Li; Yingrui Li; Shiping Liu; Alex Loukas; Guilherme Oliveira; Shoba Ranganathan; Gabriel Rinaldi; David Rollinson; Jun Wang; Jian Wang; Xuan Wu; Zijun Xiong; Xun Xu; Huanming Yang; Linfeng Yang; Robin B Gasser
Whole-genome sequence of Schistosoma haematobium.
Nature genetics 2012;44(2):221-5.
2012: Supawadee Piratae; Banchob Sripa; Smarn Tesana; Sirikanda Thanasuwan; Paul J Brindley; Veerachai Eursitthichai; Malcolm K Jones; Alex Loukas; Erica Lovas; Thewarach Laha
Molecular characterization of a tetraspanin from the human liver fluke, Opisthorchis viverrini.
PLoS neglected tropical diseases 2012;6(12):e1939.
2012: Gabriel Rinaldi; Sutas Suttiprapa; Jose F. Tort; Isheng J Tsai; Daniel J Turner; Matthew Berriman; Sabine E Eckert; Kristine J Kines; Victoria H Mann; Paul J Brindley
Germline transgenesis and insertional mutagenesis in Schistosoma mansoni mediated by murine leukemia virus.
PLoS pathogens 2012;8(7):e1002820.
2012: Danielle E Skinner; Pablo Smircich; Sutas Suttiprapa; David L Williams; Alexis A Cogswell; Victoria H Mann; Gabriel Rinaldi; Paul J Brindley
Vasa-Like DEAD-Box RNA Helicases of Schistosoma mansoni.
PLoS neglected tropical diseases 2012;6(6):e1686.
2012: Banchob Sripa; Bandit Thinkhamrop; Ponlapat Yonglitthipagon; Vajarabhongsa Bhudhisawasdi; Paul J Brindley; Sasithorn Kaewkes; Thewarach Laha; Alex Loukas; Eimorn Mairiang; Jason Mulvenna; Maria Victoria Periago; Paiboon Sithithaworn; Jeffrey Bethony
Elevated plasma IL-6 associates with increased risk of advanced fibrosis and cholangiocarcinoma in individuals infected by Opisthorchis viverrini.
PLoS neglected tropical diseases 2012;6(5):e1654.
2011: Gabriel Rinaldi; Sutas Suttiprapa; Mary A Ayuk; Fred A Lewis; Yung-san Liang; Alex Loukas; Victoria H Mann; Tunika I Okatcha; Anastas Popratiloff; Paul J Brindley
Genetic manipulation of Schistosoma haematobium, the neglected schistosome.
PLoS neglected tropical diseases 2011;5(10):e1348.
2011: Sujit S Nair; Kazufumi Ohshiro; Suresh B Pakala; Maria V Periago; Banchob Sripa; Sutas Suttiprapa; Jeffrey Bethony; Anitha Bommana; Paul J Brindley; Peter J Hotez; Thewarach Laha; Amanda J Lyon; Rakesh Kumar
Inflammatory response to liver fluke Opisthorchis viverrini in mice depends on host master coregulator MTA1, a marker for parasite-induced cholangiocarcinoma in humans.
Hepatology (Baltimore, Md.) 2011;54(4):1388-97.
2011: Jittiyawadee Sripa; Neil D Young; Paul J Brindley; Robin B Gasser; Sasithorn Kaewkes; Alex Loukas; Porntip Pinlaor; Mark W Robinson; Banchob Sripa; Thewarach Laha
RNA interference targeting cathepsin B of the carcinogenic liver fluke, Opisthorchis viverrini.
Parasitology international 2011;60(3):283-8.
2011: Banchob Sripa; Jeffrey Bethony; Peter J Hotez; Sasithorn Kaewkes; Thewarach Laha; Alex Loukas; Eimorn Mairiang; Jason Mulvenna; Paiboon Sithithaworn; Paul J Brindley
Opisthorchiasis and Opisthorchis-associated cholangiocarcinoma in Thailand and Laos.
Acta tropica 2011;120 Suppl 1():S158-68.
2011: Victoria H Mann; Gabriel Rinaldi; Sutas Suttiprapa; Paul J Brindley
Establishing transgenic schistosomes.
PLoS neglected tropical diseases 2011;5(8):e1230.
2011: Sujit S Nair; Kazufumi Ohshiro; Suresh B Pakala; Maria V Periago; Gabriel Rinaldi; Sutas Suttiprapa; Jeffrey Bethony; Anitha Bommana; Paul J Brindley; Peter J Hotez; Brian Keegan; Amanda J Lyon; Rakesh Kumar
The metastasis-associated protein-1 gene encodes a host permissive factor for schistosomiasis, a leading global cause of inflammation and cancer.
Hepatology (Baltimore, Md.) 2011;54(1):285-95.
2011: Gabriel Rinaldi; Sutas Suttiprapa; Paul J Brindley
Quantitative retrotransposon anchored PCR confirms transduction efficiency of transgenes in adult Schistosoma mansoni.
Molecular and biochemical parasitology 2011;177(1):70-6.
2010: Neil D Young; Aaron R Jex; Cinzia Cantacessi; Bronwyn E Campbell; Thewarach Laha; Woon-Mok Sohn; Banchob Sripa; Alex Loukas; Paul J Brindley; Robin Gasser
Progress on the transcriptomics of carcinogenic liver flukes of humans--unique biological and biotechnological prospects.
Biotechnology advances 2010;28(6):859-70.
2010: Elissaveta B Tchoubrieva; Poh C Ong; Robert N Pike; Paul J Brindley; Bernd H Kalinna
Vector-based RNA interference of cathepsin B1 in Schistosoma mansoni.
Cellular and molecular life sciences : CMLS 2010;67(21):3739-48.
2010: Jittiyawadee Sripa; Thewarach Laha; Joyce To; Paul J Brindley; Banchob Sripa; Sasithorn Kaewkes; John P Dalton; Mark W Robinson
Secreted cysteine proteases of the carcinogenic liver fluke, Opisthorchis viverrini: regulation of cathepsin F activation by autocatalysis and trans-processing by cathepsin B.
Cellular microbiology 2010;12(6):781-95.
2010: Jason Mulvenna; Banchob Sripa; Paul J Brindley; Jeffrey Gorman; Malcolm K Jones; Michelle L Colgrave; Alun Jones; Sujeevi Nawaratna; Thewarach Laha; Sutas Suttiprapa; Michael J Smout; Alex Loukas
The secreted and surface proteomes of the adult stage of the carcinogenic human liver fluke Opisthorchis viverrini.
Proteomics 2010;10(5):1063-78.
2010: Victoria H Mann; Maria E Morales; Gabriel Rinaldi; Paul J Brindley
Culture for genetic manipulation of developmental stages of Schistosoma mansoni.
Parasitology 2010;137(3):451-62.
2010: Banchob Sripa; Sasithorn Kaewkes; Pewpan M Intapan; Wanchai Maleewong; Paul J Brindley
Food-borne trematodiases in Southeast Asia epidemiology, pathology, clinical manifestation and control.
Advances in parasitology 2010;72():305-50.
2010: Neil D Young; Bronwyn E Campbell; Ross S Hall; Aaron R Jex; Cinzia Cantacessi; Thewarach Laha; Woon-Mok Sohn; Banchob Sripa; Alex Loukas; Paul J Brindley; Robin Gasser
Unlocking the transcriptomes of two carcinogenic parasites, Clonorchis sinensis and Opisthorchis viverrini.
PLoS neglected tropical diseases 2010;4(6):e719.
2010: Kristine J Kines; Gabriel Rinaldi; Tunika I Okatcha; Maria E Morales; Victoria H Mann; Jose F. Tort; Paul J Brindley
Electroporation facilitates introduction of reporter transgenes and virions into schistosome eggs.
PLoS neglected tropical diseases 2010;4(2):e593.
2009: Banchob Sripa; Eimorn Mairiang; Bandit Thinkhamrop; Thewarach Laha; Sasithorn Kaewkes; Paiboon Sithithaworn; Smarn Tessana; Alex Loukas; Paul J Brindley; Jeffrey Bethony
Advanced periductal fibrosis from infection with the carcinogenic human liver fluke Opisthorchis viverrini correlates with elevated levels of interleukin-6.
Hepatology (Baltimore, Md.) 2009;50(4):1273-81.
2009: Gabriel Rinaldi; Maria E Morales; Yousef N Alrefaei; Martín Cancela; Estela Castillo; John P Dalton; Jose F. Tort; Paul J Brindley
RNA interference targeting leucine aminopeptidase blocks hatching of Schistosoma mansoni eggs.
Molecular and biochemical parasitology 2009;167(2):118-26.
2009: Sutas Suttiprapa; Jason Mulvenna; Ngo Thi Huong; Mark S Pearson; Paul J Brindley; Thewarach Laha; Sopit Wongkham; Sasithorn Kaewkes; Banchob Sripa; Alex Loukas
Ov-APR-1, an aspartic protease from the carcinogenic liver fluke, Opisthorchis viverrini: functional expression, immunolocalization and subsite specificity.
The international journal of biochemistry & cell biology 2009;41(5):1148-56.
2009: John P Dalton; Paul J Brindley; Sheila Donnelly; Mark W Robinson
The enigmatic asparaginyl endopeptidase of helminth parasites.
Trends in parasitology 2009;25(2):59-61.
2009: Paul J Brindley; Makedonka Mitreva; Elodie Ghedin; Sara Lustigman
Helminth genomics: The implications for human health.
PLoS neglected tropical diseases 2009;3(10):e538.
2009: Geoffrey N Gobert; Luke Moertel; Paul J Brindley; Donald P McManus
Developmental gene expression profiles of the human pathogen Schistosoma japonicum.
BMC genomics 2009;10():128.
2009: Porntip Pinlaor; Natthawut Kaewpitoon; Thewarach Laha; Banchob Sripa; Sasithorn Kaewkes; Maria E Morales; Victoria H Mann; Sandi K Parriott; Sutas Suttiprapa; Mark W Robinson; Joyce To; John P Dalton; Alex Loukas; Paul J Brindley
Cathepsin F cysteine protease of the human liver fluke, Opisthorchis viverrini.
PLoS neglected tropical diseases 2009;3(3):e398.
2008: Thewarach Laha; Jittiyawadee Sripa; Banchob Sripa; Mark Pearson; Leon Tribolet; Sasithorn Kaewkes; Paiboon Sithithaworn; Paul J Brindley; Alex Loukas
Asparaginyl endopeptidase from the carcinogenic liver fluke, Opisthorchis viverrini, and its potential for serodiagnosis.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2008;12(6):e49-59.
2008: Peter J Hotez; Jeffrey Bethony; Sergio Costa Oliveira; Paul J Brindley; Alex Loukas
Multivalent anthelminthic vaccine to prevent hookworm and schistosomiasis.
Expert review of vaccines 2008;7(6):745-52.
2008: Sutas Suttiprapa; Alex Loukas; Thewarach Laha; Sopit Wongkham; Sasithorn Kaewkes; Soraya Gaze; Paul J Brindley; Banchob Sripa
Characterization of the antioxidant enzyme, thioredoxin peroxidase, from the carcinogenic human liver fluke, Opisthorchis viverrini.
Molecular and biochemical parasitology 2008;160(2):116-22.
2008: Kristine J Kines; Maria E Morales; Victoria H Mann; Geoffrey N Gobert; Paul J Brindley
Integration of reporter transgenes into Schistosoma mansoni chromosomes mediated by pseudotyped murine leukemia virus.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(8):2936-48.
2008: Natthawut Kaewpitoon; Thewarach Laha; Sasithorn Kaewkes; Puangrat Yongvanit; Paul J Brindley; Alex Loukas; Banchob Sripa
Characterization of cysteine proteases from the carcinogenic liver fluke, Opisthorchis viverrini.
Parasitology research 2008;102(4):757-64.
2008: Jinjiang Fan; W Yang; Paul J Brindley
Lysophospholipase from the human blood fluke, Schistosoma japonicum.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2008;12(2):143-51.
2008: Maria E Morales; Gabriel Rinaldi; Geoffrey N Gobert; Kristine J Kines; Jose F. Tort; Paul J Brindley
RNA interference of Schistosoma mansoni cathepsin D, the apical enzyme of the hemoglobin proteolysis cascade.
Molecular and biochemical parasitology 2008;157(2):160-8.
2008: Victoria H Mann; Maria E Morales; K J Kines; Paul J Brindley
Transgenesis of schistosomes: approaches employing mobile genetic elements.
Parasitology 2008;135(2):141-53.
2008: Gabriel Rinaldi; Maria E Morales; Martín Cancela; Estela Castillo; Paul J Brindley; Jose F. Tort
Development of functional genomic tools in trematodes: RNA interference and luciferase reporter gene activity in Fasciola hepatica.
PLoS neglected tropical diseases 2008;2(7):e260.
2007: Maria E Morales; Victoria H Mann; Kristine J Kines; Geoffrey N Gobert; Malcolm J Fraser; Bernd H Kalinna; Jason M Correnti; Edward J Pearce; Paul J Brindley
piggyBac transposon mediated transgenesis of the human blood fluke, Schistosoma mansoni.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(13):3479-89.
2007: Banchob Sripa; Sasithorn Kaewkes; Paiboon Sithithaworn; Eimorn Mairiang; Thewarach Laha; Michael J Smout; Chawalit Pairojkul; Vajarabhongsa Bhudhisawasdi; Smarn Tesana; Bandit Thinkamrop; Jeffrey Bethony; Alex Loukas; Paul J Brindley
Liver fluke induces cholangiocarcinoma.
PLoS medicine 2007;4(7):e201.
2007: Bernd H Kalinna; Paul J Brindley
Manipulating the manipulators: advances in parasitic helminth transgenesis and RNAi.
Trends in parasitology 2007;23(5):197-204.
2007: Paul J Brindley; Edward J Pearce
Genetic manipulation of schistosomes.
International journal for parasitology 2007;37(5):465-73.
2007: Jeffrey W Koehler; Maria E Morales; Bryan D Shelby; Paul J Brindley
Aspartic protease activities of schistosomes cleave mammalian hemoglobins in a host-specific manner.
Memórias do Instituto Oswaldo Cruz 2007;102(1):83-5.
2007: Claudia Copeland; Victoria H Mann; Paul J Brindley
Both sense and antisense strands of the LTR of the Schistosoma mansoni Pao-like retrotransposon Sinbad drive luciferase expression.
Molecular genetics and genomics : MGG 2007;277(2):161-70.
2007: Thewarach Laha; Alex Loukas; Supatra Wattanasatitarpa; Jenjira Somprakhon; Nonglack Kewgrai; Paiboon Sithithaworn; Sasithorn Kaewkes; Makedonka Mitreva; Paul J Brindley
The bandit, a new DNA transposon from a hookworm-possible horizontal genetic transfer between host and parasite.
PLoS neglected tropical diseases 2007;1(1):e35.
2007: Thewarach Laha; Porntip Pinlaor; Jason Mulvenna; Banchob Sripa; Manop Sripa; Michael J Smout; Robin B Gasser; Paul J Brindley; Alex Loukas
Gene discovery for the carcinogenic human liver fluke, Opisthorchis viverrini.
BMC genomics 2007;8():189.
2006: Claudia Copeland; Fred A Lewis; Paul J Brindley
Identification of the Boudicca and Sinbad retrotransposons in the genome of the human blood fluke Schistosoma haematobium.
Memórias do Instituto Oswaldo Cruz 2006;101(5):565-71.
2006: Thewarach Laha; Nonglack Kewgrai; Alex Loukas; Paul J Brindley
The dingo non-long terminal repeat retrotransposons from the genome of the hookworm, Ancylostoma caninum.
Experimental parasitology 2006;113(3):142-53.
2006: Peter J Didier; Jennifer N Phillips; Dorothy J Kuebler; Mohamed Nasr; Paul J Brindley; Mary E Stovall; Lisa C Bowers; Elizabeth S Didier
Antimicrosporidial activities of fumagillin, TNP-470, ovalicin, and ovalicin derivatives in vitro and in vivo.
Antimicrobial agents and chemotherapy 2006;50(6):2146-55.
2006: Kristine J Kines; Victoria H Mann; Maria E Morales; Bryan D Shelby; Bernd H Kalinna; Geoffrey N Gobert; Sharon R Chirgwin; Paul J Brindley
Transduction of Schistosoma mansoni by vesicular stomatitis virus glycoprotein-pseudotyped Moloney murine leukemia retrovirus.
Experimental parasitology 2006;112(4):209-20.
2005: Paul J Brindley
The molecular biology of schistosomes.
Trends in parasitology 2005;21(11):533-6.
2005: Jason M Correnti; Paul J Brindley; Edward J Pearce
Long-term suppression of cathepsin B levels by RNA interference retards schistosome growth.
Molecular and biochemical parasitology 2005;143(2):209-15.
2005: Elizabeth S Didier; Joseph A Maddry; Paul J Brindley; Mary E Stovall; Peter J Didier
Therapeutic strategies for human microsporidia infections.
Expert review of anti-infective therapy 2005;3(3):419-34.
2005: Sara Gomez Gallego; Alex Loukas; Robert W Slade; Franklin A Neva; Ravi Varatharajalu; Thomas B Nutman; Paul J Brindley
Identification of an astacin-like metallo-proteinase transcript from the infective larvae of Strongyloides stercoralis.
Parasitology international 2005;54(2):123-33.
2005: Elizabeth S Didier; Lisa C Bowers; Mary E Stovall; Dorothy Kuebler; Derek Mittleider; Paul J Brindley; Peter J Didier
Antimicrosporidial activity of (fluoro)quinolones in vitro and in vivo.
Folia parasitologica 2005;52(1-2):173-81.
2005: Ivona Pandrea; Derek Mittleider; Paul J Brindley; Elizabeth S Didier; David L Robertson
Phylogenetic relationships of methionine aminopeptidase 2 among Encephalitozoon species and genotypes of microsporidia.
Molecular and biochemical parasitology 2005;140(2):141-52.
2005: Alexandra Schulmeister; Oliver Heyers; Maria E Morales; Paul J Brindley; Richard Lucius; Grit Meusel; Bernd H Kalinna
Organization and functional analysis of the Schistosoma mansoni cathepsin D-like aspartic protease gene promoter.
Biochimica et biophysica acta 2005;1727(1):27-34.
2005: Thewarach Laha; Nonglack Kewgrai; Alex Loukas; Paul J Brindley
Characterization of SR3 reveals abundance of non-LTR retrotransposons of the RTE clade in the genome of the human blood fluke, Schistosoma mansoni.
BMC genomics 2005;6():154.
2005: Claudia Copeland; Victoria H Mann; Maria E Morales; Bernd H Kalinna; Paul J Brindley
The Sinbad retrotransposon from the genome of the human blood fluke, Schistosoma mansoni, and the distribution of related Pao-like elements.
BMC evolutionary biology 2005;5():20.
2004: Elizabeth S Didier; Mary E Stovall; Linda C Green; Paul J Brindley; Karol Sestak; Peter J Didier
Epidemiology of microsporidiosis: sources and modes of transmission.
Veterinary parasitology 2004;126(1-2):145-66.
2004: Thewarach Laha; Alex Loukas; Danielle J Smyth; Claudia Copeland; Paul J Brindley
The fugitive LTR retrotransposon from the genome of the human blood fluke, Schistosoma mansoni.
International journal for parasitology 2004;34(12):1365-75.
2004: Maria E Morales; Bernd H Kalinna; Oliver Heyers; Victoria H Mann; Alexandra Schulmeister; Claudia Copeland; Alex Loukas; Paul J Brindley
Genomic organization of the Schistosoma mansoni aspartic protease gene, a platyhelminth orthologue of mammalian lysosomal cathepsin D.
Gene 2004;338(1):99-109.
2004: Donald P McManus; Wei Hu; Paul J Brindley; Zheng Feng; Ze-Guang Han
Schistosome transcriptome analysis at the cutting edge.
Trends in parasitology 2004;20(7):301-4.
2004: Alex Loukas; Jeffrey Bethony; Angela L Williamson; Gaddam Goud; Susana Mendez; Bin Zhan; John M Hawdon; Maria Elena Bottazzi; Paul J Brindley; Peter J Hotez
Vaccination of dogs with a recombinant cysteine protease from the intestine of canine hookworms diminishes the fecundity and growth of worms.
The Journal of infectious diseases 2004;189(10):1952-61.
2004: Wei Hu; Paul J Brindley; Donald P McManus; Zheng Feng; Ze-Guang Han
Schistosome transcriptomes: new insights into the parasite and schistosomiasis.
Trends in molecular medicine 2004;10(5):217-25.
2004: Elaine McCarthy; Colin M Stack; Sheila M Donnelly; Sean Doyle; Victoria H Mann; Paul J Brindley; Michael Stewart; Tim A Day; Aaron G Maule; John P Dalton
Leucine aminopeptidase of the human blood flukes, Schistosoma mansoni and Schistosoma japonicum.
International journal for parasitology 2004;34(6):703-14.
2004: Claudia Copeland; Oliver Heyers; Bernd H Kalinna; Andreas Bachmair; Peter F Stadler; Ivo L Hofacker; Paul J Brindley
Structural and evolutionary analysis of the transcribed sequence of Boudicca, a Schistosoma mansoni retrotransposon.
Gene 2004;329():103-14.
2003: Oliver Heyers; Anna Walduck; Paul J Brindley; Wilfrid Bleiss; Richard Lucius; Tomislav Dorbic; Burghardt Wittig; Bernd H Kalinna
Schistosoma mansoni miracidia transformed by particle bombardment infect Biomphalaria glabrata snails and develop into transgenic sporocysts.
Experimental parasitology 2003;105(2):174-8.
2003: Jinjiang Fan; Xiaoxian Gan; Wen Yang; Liying Shen; Donald P McManus; Paul J Brindley
A Schistosoma japonicum very low-density lipoprotein-binding protein.
The international journal of biochemistry & cell biology 2003;35(10):1436-51.
2003: Angela L Williamson; Paul J Brindley; David P Knox; Peter J Hotez; Alex Loukas
Digestive proteases of blood-feeding nematodes.
Trends in parasitology 2003;19(9):417-23.
2003: Claudia Copeland; Paul J Brindley; Oliver Heyers; Scott F Michael; David A Johnston; David L Williams; Alasdair Ivens; Bernd H Kalinna
Boudicca, a retrovirus-like long terminal repeat retrotransposon from the genome of the human blood fluke Schistosoma mansoni.
Journal of virology 2003;77(11):6153-66.
2003: John P Dalton; Paul J Brindley; Dave P Knox; Ciaran P Brady; Peter J Hotez; Sheila Donnelly; Sandra M O'Neill; Grace Mulcahy; Alex Loukas
Helminth vaccines: from mining genomic information for vaccine targets to systems used for protein expression.
International journal for parasitology 2003;33(5-6):621-40.
2003: A L Williamson; Paul J Brindley; Alex Loukas
Hookworm cathepsin D aspartic proteases: contributing roles in the host-specific degradation of serum proteins and skin macromolecules.
Parasitology 2003;126(Pt 2):179-85.
2003: Paul J Brindley; Thewarach Laha; Donald P McManus; Alex Loukas
Mobile genetic elements colonizing the genomes of metazoan parasites.
Trends in parasitology 2003;19(2):79-87.
2003: Angela L Williamson; Paul J Brindley; Giovanni Abbenante; Bennett J D Datu; Paul Prociv; Colin Berry; Karen Girdwood; David I Pritchard; David P Fairlie; Peter J Hotez; Bin Zhan; Alex Loukas
Hookworm aspartic protease, Na-APR-2, cleaves human hemoglobin and serum proteins in a host-specific fashion.
The Journal of infectious diseases 2003;187(3):484-94.
2003: Elizabeth S Didier; Aaron D Martin; Mary E Stovall; Xavier Alvarez; Derek Mittleider; Linda C Green; Lisa C Bowers; Ardeth K Plauche; Peter J Didier; Paul J Brindley
Methionine aminopeptidase 2 expression in microsporidia.
The Journal of eukaryotic microbiology 2003;50 Suppl():569-71.
2002: Derek Mittleider; Linda C Green; Victoria H Mann; Scott F Michael; Elizabeth S Didier; Paul J Brindley
Sequence survey of the genome of the opportunistic microsporidian pathogen, Vittaforma corneae.
The Journal of eukaryotic microbiology 2002;49(5):393-401.
2002: Angela L Williamson; Paul J Brindley; Giovanni Abbenante; Paul Prociv; Colin Berry; Karen Girdwood; David I Pritchard; David P Fairlie; Peter J Hotez; John P Dalton; Alex Loukas
Cleavage of hemoglobin by hookworm cathepsin D aspartic proteases and its potential contribution to host specificity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(11):1458-60.
2002: Thewarach Laha; Paul J Brindley; Michael J Smout; Christiana K Verity; Donald P McManus; Alex Loukas
Reverse transcriptase activity and untranslated region sharing of a new RTE-like, non-long terminal repeat retrotransposon from the human blood fluke, Schistosoma japonicum.
International journal for parasitology 2002;32(9):1163-74.
2002: Christiana K Verity; Donald P McManus; Paul J Brindley
Cellular responses to Schistosoma japonicum cathepsin D aspartic protease.
Parasite immunology 2002;24(7):363-7.
2002: Thewarach Laha; Paul J Brindley; Christiana K Verity; Donald P McManus; Alex Loukas
pido, a non-long terminal repeat retrotransposon of the chicken repeat 1 family from the genome of the Oriental blood fluke, Schistosoma japonicum.
Gene 2002;284(1-2):149-59.
2001: Ross I Brinkworth; Paul Prociv; Alex Loukas; Paul J Brindley
Hemoglobin-degrading, aspartic proteases of blood-feeding parasites: substrate specificity revealed by homology models.
The Journal of biological chemistry 2001;276(42):38844-51.
2001: Alex Loukas; Malcolm K Jones; LT King; Paul J Brindley; Donald P McManus
Receptor for Fc on the surfaces of schistosomes.
Infection and immunity 2001;69(6):3646-51.
2001: BJ Bogitsh; John P Dalton; C P Brady; Paul J Brindley
Gut-associated immunolocalization of the Schistosoma mansoni cysteine proteases, SmCL1 and SmCL2.
The Journal of parasitology 2001;87(2):237-41.
2001: Christiana K Verity; Alex Loukas; Donald P McManus; Paul J Brindley
Schistosoma japonicum cathepsin D aspartic protease cleaves human IgG and other serum components.
Parasitology 2001;122(Pt 4):415-21.
2001: Christiana K Verity; Donald P McManus; Paul J Brindley
Vaccine efficacy of recombinant cathepsin D aspartic protease from Schistosoma japonicum.
Parasite immunology 2001;23(3):153-62.
2001: Thewarach Laha; Alex Loukas; Christiana K Verity; Donald P McManus; Paul J Brindley
Gulliver, a long terminal repeat retrotransposon from the genome of the oriental blood fluke Schistosoma japonicum.
Gene 2001;264(1):59-68.
2001: Paul J Brindley; Bernd H Kalinna; JY Wong; BJ Bogitsh; LT King; Danielle J Smyth; Christiana K Verity; Giovanni Abbenante; Ross I Brinkworth; David P Fairlie; Mark L Smythe; P J Milburn; Helle Bielefeldt-Ohmann; Y Zheng; Donald P McManus
Proteolysis of human hemoglobin by schistosome cathepsin D.
Molecular and biochemical parasitology 2001;112(1):103-12.
2000: Alex Loukas; Andrew Dowd; Paul Prociv; Paul J Brindley
Purification of a diagnostic, secreted cysteine protease-like protein from the hookworm Ancylostoma caninum.
Parasitology international 2000;49(4):327-33.
2000: L Hola-Jamriska; LT King; John P Dalton; V H Mann; JG Aaskov; Paul J Brindley
Functional expression of dipeptidyl peptidase I (Cathepsin C) of the oriental blood fluke Schistosoma japonicum in Trichoplusia ni insect cells.
Protein expression and purification 2000;19(3):384-92.
2000: Ciaran P Brady; Ross I Brinkworth; John P Dalton; Andrew Dowd; Christiana K Verity; Paul J Brindley
Molecular modeling and substrate specificity of discrete cruzipain-like and cathepsin L-like cysteine proteinases of the human blood fluke Schistosoma mansoni.
Archives of biochemistry and biophysics 2000;380(1):46-55.
2000: Thewarach Laha; Donald P McManus; Alex Loukas; Paul J Brindley
Sjalpha elements, short interspersed element-like retroposons bearing a hammerhead ribozyme motif from the genome of the oriental blood fluke Schistosoma japonicum.
Biochimica et biophysica acta 2000;1492(2-3):477-82.
2000: Ross I Brinkworth; S A Harrop; Paul Prociv; Paul J Brindley
Host specificity in blood feeding parasites: a defining contribution by haemoglobin-degrading enzymes?
International journal for parasitology 2000;30(6):785-90.
2000: Ross I Brinkworth; Jose F. Tort; Paul J Brindley; John P Dalton
Phylogenetic relationships and theoretical model of human cathepsin W (lymphopain), a cysteine proteinase from cytotoxic T lymphocytes.
The international journal of biochemistry & cell biology 2000;32(3):373-84.
2000: Ciaran P Brady; Paul J Brindley; Andrew Dowd; John P Dalton
Schistosoma mansoni: differential expression of cathepsins L1 and L2 suggests discrete biological functions for each enzyme.
Experimental parasitology 2000;94(2):75-83.
1999: W Sun; S Liu; Paul J Brindley; Donald P McManus
Bacterial expression and characterization of functional recombinant triosephosphate isomerase from Schistosoma japonicum.
Protein expression and purification 1999;17(3):410-3.
1999: Christiana K Verity; Donald P McManus; Paul J Brindley
Developmental expression of cathepsin D aspartic protease in Schistosoma japonicum.
International journal for parasitology 1999;29(11):1819-24.
1999: AC Drew; Dennis J Minchella; LT King; D Rollinson; Paul J Brindley
SR2 elements, non-long terminal repeat retrotransposons of the RTE-1 lineage from the human blood fluke Schistosoma mansoni.
Molecular biology and evolution 1999;16(9):1256-69.
1999: Ciaran P Brady; Andrew Dowd; Jose F. Tort; Leda Roche; B Condon; Sandra M O'Neill; Paul J Brindley; John P Dalton
The cathepsin L-like proteinases of liver fluke and blood fluke parasites of the trematode genera Fasciola and Schistosoma.
Biochemical Society transactions 1999;27(4):740-5.
1999: L Hola-Jamriska; John P Dalton; JG Aaskov; Paul J Brindley
Dipeptidyl peptidase I and III activities of adult schistosomes.
Parasitology 1999;118 ( Pt 3)():275-82.
1999: Craig Hooker; Paul J Brindley
Cloning of a cDNA encoding SjIrV1, a Schistosoma japonicum calcium-binding protein similar to calnexin, and expression of the recombinant protein in Escherichia coli.
Biochimica et biophysica acta 1999;1429(2):331-41.
1999: Jose F. Tort; Paul J Brindley; D Knox; K H Wolfe; John P Dalton
Proteinases and associated genes of parasitic helminths.
Advances in parasitology 1999;43():161-266.
1999: Ciaran P Brady; Andrew Dowd; Paul J Brindley; Thecla Ryan; SR Day; John P Dalton
Recombinant expression and localization of Schistosoma mansoni cathepsin L1 support its role in the degradation of host hemoglobin.
Infection and immunity 1999;67(1):368-74.
1998: Jinjiang Fan; Dennis J Minchella; SR Day; Donald P McManus; W U Tiu; Paul J Brindley
Generation, identification, and evaluation of expressed sequence tags from different developmental stages of the Asian blood fluke Schistosoma japonicum.
Biochemical and biophysical research communications 1998;252(2):348-56.
1998: Jinjiang Fan; Paul J Brindley
Characterization of cDNAs encoding a new family of tetraspanins from schistosomes--the Sj25 family.
Gene 1998;219(1-2):1-8.
1998: S G Gallego; R W Slade; Paul J Brindley
A cDNA encoding a pepsinogen-like, aspartic protease from the human roundworm parasite Strongyloides stercoralis.
Acta tropica 1998;71(1):17-26.
1998: L Hola-Jamriska; Jose F. Tort; John P Dalton; SR Day; Jinjiang Fan; JG Aaskov; Paul J Brindley
Cathepsin C from Schistosoma japonicum--cDNA encoding the preproenzyme and its phylogenetic relationships.
European journal of biochemistry / FEBS 1998;255(3):527-34.
1998: AC Drew; Paul J Brindley; Fred A Lewis; Y S Liang; Dennis J Minchella
Tandemly repeated genomic sequence demonstrates inter- and intra-strain genetic variation in Schistosoma japonicum.
Tropical medicine & international health : TM & IH 1998;3(5):373-80.
1997: Jinjiang Fan; Craig Hooker; Donald P McManus; Paul J Brindley
A new member of the transmembrane 4 superfamily (TM4SF) of proteins from schistosomes, expressed by larval and adult Schistosoma japonicum.
Biochimica et biophysica acta 1997;1329(1):18-25.
1997: Paul J Brindley; Bernd H Kalinna; John P Dalton; SR Day; JY Wong; Mark L Smythe; Donald P McManus
Proteolytic degradation of host hemoglobin by schistosomes.
Molecular and biochemical parasitology 1997;89(1):1-9.
1997: John P Dalton; SR Day; AC Drew; Paul J Brindley
A method for the isolation of schistosome eggs and miracidia free of contaminating host tissues.
Parasitology 1997;115 ( Pt 1)():29-32.
1997: AC Drew; Paul J Brindley
A retrotransposon of the non-long terminal repeat class from the human blood fluke Schistosoma mansoni. Similarities to the chicken-repeat-1-like elements of vertebrates.
Molecular biology and evolution 1997;14(6):602-10.
1997: JY Wong; S A Harrop; SR Day; Paul J Brindley
Schistosomes express two forms of cathepsin D.
Biochimica et biophysica acta 1997;1338(2):156-60.
1997: John P Dalton; K A Clough; M K Jones; Paul J Brindley
The cysteine proteinases of Schistosoma mansoni cercariae.
Parasitology 1997;114 ( Pt 2)():105-12.
1996: Craig Hooker; Paul J Brindley
Cloning and characterisation of strain-specific transcripts encoding triosephosphate isomerase, a candidate vaccine antigen from Schistosoma japonicum.
Molecular and biochemical parasitology 1996;82(2):265-9.
1996: Ross I Brinkworth; Paul J Brindley; S A Harrop
Structural analysis of the catalytic site of AcCP-1, a cysteine proteinase secreted by the hookworm Ancylostoma caninum.
Biochimica et biophysica acta 1996;1298(1):4-8.
1996: S A Harrop; Paul Prociv; Paul J Brindley
Acasp, a gene encoding a cathepsin D-like aspartic protease from the hookworm Ancylostoma caninum.
Biochemical and biophysical research communications 1996;227(1):294-302.
1996: K A Clough; AC Drew; Paul J Brindley
Host-like sequences in the schistosome genome.
Parasitology today (Personal ed.) 1996;12(7):283-6.
1996: John P Dalton; K A Clough; M K Jones; Paul J Brindley
Characterization of the cathepsin-like cysteine proteinases of Schistosoma mansoni.
Infection and immunity 1996;64(4):1328-34.
1995: SR Day; John P Dalton; K A Clough; L Leonardo; W U Tiu; Paul J Brindley
Characterization and cloning of the cathepsin L proteinases of Schistosoma japonicum.
Biochemical and biophysical research communications 1995;217(1):1-9.
1995: John P Dalton; L Hola-Jamriska; Paul J Brindley
Asparaginyl endopeptidase activity in adult Schistosoma mansoni.
Parasitology 1995;111 ( Pt 5)():575-80.
1995: M M Becker; S A Harrop; John P Dalton; B H Kalinna; Donald P McManus; Paul J Brindley
Cloning and characterization of the Schistosoma japonicum aspartic proteinase involved in hemoglobin degradation.
The Journal of biological chemistry 1995;270(41):24496-501.
1995: John P Dalton; A M Smith; K A Clough; Paul J Brindley
Digestion of haemoglobin by schistosomes: 35 years on.
Parasitology today (Personal ed.) 1995;11(8):299-303.
1995: S A Harrop; Paul Prociv; Paul J Brindley
Amplification and characterization of cysteine proteinase genes from nematodes.
Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft für Technische Zusammenarbeit (GTZ) 1995;46(2):119-22.
1995: Craig Hooker; W Yang; M M Becker; GJ Waine; B H Kalinna; K A Nimmo; Donald P McManus; Paul J Brindley
Schistosoma japonicum: heterogeneity in paramyosin genes.
Acta tropica 1995;59(2):131-41.
1995: AC Drew; Paul J Brindley
Female-specific sequences isolated from Schistosoma mansoni by representational difference analysis.
Molecular and biochemical parasitology 1995;71(2):173-81.
1995: S A Harrop; N Sawangjaroen; Paul Prociv; Paul J Brindley
Characterization and localization of cathepsin B proteinases expressed by adult Ancylostoma caninum hookworms.
Molecular and biochemical parasitology 1995;71(2):163-71.
1994: Andrew Dowd; John P Dalton; Alex Loukas; Paul Prociv; Paul J Brindley
Secretion of cysteine proteinase activity by the zoonotic hookworm Ancylostoma caninum.
The American journal of tropical medicine and hygiene 1994;51(3):341-7.
1994: A M Smith; John P Dalton; K A Clough; C L Kilbane; S A Harrop; N Hole; Paul J Brindley
Adult Schistosoma mansoni express cathepsin L proteinase activity.
Molecular and biochemical parasitology 1994;67(1):11-9.
1994: J Ellis; K Luton; P R Baverstock; Paul J Brindley; K A Nimmo; Alan M Johnson
The phylogeny of Neospora caninum.
Molecular and biochemical parasitology 1994;64(2):303-11.
1994: Paul J Brindley
Relationships between chemotherapy and immunity in schistosomiasis.
Advances in parasitology 1994;34():133-61.