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Xiang-Lei Yang

Research Profile

Chemicals & Drugs

Concepts & Ideas

Procedures

X Ray Crystallography

Genes & Molecular Sequences

Amino Acid Sequences

Physiology

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Publications

TOP 3
Huihao Zhou; Litao Sun; Xiang-Lei Yang; Paul Schimmel
ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase.
Mathew Sajish; Delgado M Valdez; Xiang-Lei Yang; Quansheng Zhou; Min Guo; Mili Kapoor; Sunghoon Kim; Shuji Kishi; Sunhee Lee; Paul Schimmel
Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling.
Guangsen Fu; Yi Shi; Na Wei; Tao Xu; Xiang-Lei Yang
tRNA-controlled nuclear import of a human tRNA synthetase.

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All Publications

2013: Huihao Zhou; Litao Sun; Xiang-Lei Yang; Paul Schimmel
ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase.
Nature 2013;494(7435):121-4.
2012: Mathew Sajish; Delgado M Valdez; Xiang-Lei Yang; Quansheng Zhou; Min Guo; Mili Kapoor; Sunghoon Kim; Shuji Kishi; Sunhee Lee; Paul Schimmel
Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling.
Nature chemical biology 2012;8(6):547-54.
2012: Guangsen Fu; Yi Shi; Na Wei; Tao Xu; Xiang-Lei Yang
tRNA-controlled nuclear import of a human tRNA synthetase.
The Journal of biological chemistry 2012;287(12):9330-4.
2012: Xiaoling Xu; Hui-Min Zhang; Min Guo; Shuji Kishi; Alan G Marshall; Yi Shi; Eric C Swindell; Xiang-Lei Yang
Unique domain appended to vertebrate tRNA synthetase is essential for vascular development.
Nature communications 2012;3():681.
2011: My-Nuong Vo; Xiang-Lei Yang; Paul Schimmel
Dissociating quaternary structure regulates cell-signaling functions of a secreted human tRNA synthetase.
The Journal of biological chemistry 2011;286(13):11563-8.
2011: Mir Hussain Nawaz; Eve Merriman; Xiang-Lei Yang; Paul Schimmel
p23H implicated as cis/trans regulator of AlaXp-directed editing for mammalian cell homeostasis.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(7):2723-8.
2010: Min Guo; Paul Schimmel; Xiang-Lei Yang
Functional expansion of human tRNA synthetases achieved by structural inventions.
FEBS letters 2010;584(2):434-42.
2010: Quansheng Zhou; Mili Kapoor; Min Guo; Rajesh Belani; Xiaoling Xu; William B Kiosses; Melanie Hanan; Chulho Park; Eva Armour; Minh-Ha Do; Leslie A Nangle; Paul Schimmel; Xiang-Lei Yang
Orthogonal use of a human tRNA synthetase active site to achieve multifunctionality.
Nature structural & molecular biology 2010;17(1):57-61.
2009: Min Guo; Yeeting E Chong; Ryan Shapiro; Kirk Beebe; Xiang-Lei Yang; Paul Schimmel
Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma.
Nature 2009;462(7274):808-12.
2009: Rey-Ting Guo; Yeeting E Chong; Min Guo; Xiang-Lei Yang
Crystal structures and biochemical analyses suggest a unique mechanism and role for human glycyl-tRNA synthetase in Ap4A homeostasis.
The Journal of biological chemistry 2009;284(42):28968-76.
2009: MIN GUO; Yeeting E Chong; Kirk Beebe; Ryan Shapiro; Xiang-Lei Yang; Paul Schimmel
The C-Ala domain brings together editing and aminoacylation functions on one tRNA.
Science (New York, N.Y.) 2009;325(5941):744-7.
2009: Mili Kapoor; Francella J Otero; Bonnie M Slike; Karla L Ewalt; Xiang-Lei Yang
Mutational separation of aminoacylation and cytokine activities of human tyrosyl-tRNA synthetase.
Chemistry & biology 2009;16(5):531-9.
2008: Yeeting E Chong; Xiang-Lei Yang; Paul Schimmel
Natural homolog of tRNA synthetase editing domain rescues conditional lethality caused by mistranslation.
The Journal of biological chemistry 2008;283(44):30073-8.
2008: MIN GUO; Michael Ignatov; Karin Musier-Forsyth; Paul Schimmel; Xiang-Lei Yang
Crystal structure of tetrameric form of human lysyl-tRNA synthetase: Implications for multisynthetase complex formation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(7):2331-6.
2008: Mili Kapoor; Quansheng Zhou; Francella J Otero; Christopher A Myers; Alison Bates; Rajesh Belani; Jianming Liu; Jiann-Kae Luo; Eleni Tzima; Dong-Er Zhang; Xiang-Lei Yang; Paul Schimmel
Evidence for annexin II-S100A10 complex and plasmin in mobilization of cytokine activity of human TrpRS.
The Journal of biological chemistry 2008;283(4):2070-7.
2007: Xiang-Lei Yang; Mili Kapoor; Francella J Otero; Bonnie M Slike; Hiro Tsuruta; Ricardo F Frausto; Alison Bates; Karla L Ewalt; David A Cheresh; Paul Schimmel
Gain-of-function mutational activation of human tRNA synthetase procytokine.
Chemistry & biology 2007;14(12):1323-33.
2007: Leslie A Nangle; Wei Zhang; Wei Xie; Xiang-Lei Yang; Paul Schimmel
Charcot-Marie-Tooth disease-associated mutant tRNA synthetases linked to altered dimer interface and neurite distribution defect.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(27):11239-44.
2007: Xiang-Lei Yang; MIN GUO; Mili Kapoor; Karla L Ewalt; Francella J Otero; Robert J Skene; Duncan E McRee; Paul Schimmel
Functional and crystal structure analysis of active site adaptations of a potent anti-angiogenic human tRNA synthetase.
Structure (London, England : 1993) 2007;15(7):793-805.
2007: Wei Xie; Leslie A Nangle; Wei Zhang; Paul Schimmel; Xiang-Lei Yang
Long-range structural effects of a Charcot-Marie-Tooth disease-causing mutation in human glycyl-tRNA synthetase.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(24):9976-81.
2006: Wei Xie; Paul Schimmel; Xiang-Lei Yang
Crystallization and preliminary X-ray analysis of a native human tRNA synthetase whose allelic variants are associated with Charcot-Marie-Tooth disease.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 12):1243-6.
2006: Xiang-Lei Yang; Francella J Otero; Karla L Ewalt; Jianming Liu; Manal A Swairjo; Caroline Köhrer; Uttam L RajBhandary; Robert J Skene; Duncan E McRee; Paul Schimmel
Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis.
The EMBO journal 2006;25(12):2919-29.
2005: Karla L Ewalt; Xiang-Lei Yang; Francella J Otero; Jianming Liu; Bonnie M Slike; Paul Schimmel
Variant of human enzyme sequesters reactive intermediate.
Biochemistry 2005;44(11):4216-21.
2004: Xiang-Lei Yang; Paul Schimmel; Karla L Ewalt
Relationship of two human tRNA synthetases used in cell signaling.
Trends in biochemical sciences 2004;29(5):250-6.
2004: Manal A Swairjo; Francella J Otero; Xiang-Lei Yang; Martha A Lovato; Robert J Skene; Duncan E McRee; Lluis Ribas De Pouplana; Paul Schimmel
Alanyl-tRNA synthetase crystal structure and design for acceptor-stem recognition.
Molecular cell 2004;13(6):829-41.
2003: Xiang-Lei Yang; Francella J Otero; Robert J Skene; Duncan E McRee; Paul Schimmel; Lluis Ribas De Pouplana
Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15376-80.
2002: Jianming Liu; Xiang-Lei Yang; Karla L Ewalt; Paul Schimmel
Mutational switching of a yeast tRNA synthetase into a mammalian-like synthetase cytokine.
Biochemistry 2002;41(48):14232-7.
2002: Xiang-Lei Yang; Robert J Skene; Duncan E McRee; Paul Schimmel
Crystal structure of a human aminoacyl-tRNA synthetase cytokine.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(24):15369-74.