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Zhenglin Yang

Research Profile

Disorders

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Physiology

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Utah

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Retina

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Publications

TOP 3
Ke Liu; Li Jia Chen; Sylvia W Y Chiang; Timothy Y Y Lai; David T L Liu; Yi Shi; Pancy O S Tam; Mingming Yang; Zhenglin Yang; Chi Pui Pang
Associations of the C2-CFB-RDBP-SKIV2L locus with age-related macular degeneration and polypoidal choroidal vasculopathy.
Alex Jones; Sandeep Kumar; Ling Luo; Robert Marc; Manabu McCloskey; Chio Oka; Zongzhong Tong; Carl Watt; Jia-Hui Yang; Zhenglin Yang; Kang Zhang; Ning Zhang; Balamurali K Ambati; James Anderson; Heather Fillerup; Yingbin Fu
Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice.
RAHUL KHURANA; Xufang Sun; Eric Pearson; Zhenglin Yang; Jennifer Harmon; Morton F Goldberg; Kang Zhang
A reappraisal of the clinical spectrum of North Carolina macular dystrophy.

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All Publications

2013: Ke Liu; Li Jia Chen; Sylvia W Y Chiang; Timothy Y Y Lai; David T L Liu; Yi Shi; Pancy O S Tam; Mingming Yang; Zhenglin Yang; Chi Pui Pang
Associations of the C2-CFB-RDBP-SKIV2L locus with age-related macular degeneration and polypoidal choroidal vasculopathy.
Ophthalmology 2013;120(4):837-43.
2011: Alex Jones; Sandeep Kumar; Ling Luo; Robert Marc; Manabu McCloskey; Chio Oka; Zongzhong Tong; Carl Watt; Jia-Hui Yang; Zhenglin Yang; Kang Zhang; Ning Zhang; Balamurali K Ambati; James Anderson; Heather Fillerup; Yingbin Fu
Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(35):14578-83.
2009: RAHUL KHURANA; Xufang Sun; Eric Pearson; Zhenglin Yang; Jennifer Harmon; Morton F Goldberg; Kang Zhang
A reappraisal of the clinical spectrum of North Carolina macular dystrophy.
Ophthalmology 2009;116(10):1976-83.
2008: Xian Yang; Norman A Zabriskie; Vincent S Hau; Haoyu Chen; Zongzhong Tong; Daniel Gibbs; Parisa Farhi; Bradley J Katz; Ling Luo; Erik Pearson; Jason Goldsmith; Xiang Ma; Yukki Kaminoh; Yuhong Chen; Baifeng Yu; Jiexi Zeng; Kang Zhang; Zhenglin Yang
Genetic association of LOXL1 gene variants and exfoliation glaucoma in a Utah cohort.
Cell cycle (Georgetown, Tex.) 2008;7(4):521-4.
2008: Ling Luo; Jennifer Harmon; Xian Yang; Haoyu Chen; Shrena Patel; Geraldine P Mineau; Zhenglin Yang; Ryan Constantine; Jeanette Buehler; Yuuki Kaminoh; Xiang Ma; Tien Y Wong; Maonian Zhang; Kang Zhang
Familial aggregation of age-related macular degeneration in the Utah population.
Vision research 2008;48(3):494-500.
2008: Daniel Gibbs; Zhenglin Yang; Ryan Constantine; Xiang Ma; Nicola J Camp; Xian Yang; Hayou Chen; Adam Jorgenson; Vincent Hau; Andrew Dewan; Jiexi Zeng; Jennifer Harmon; Jeanette Buehler; John M Brand; Josephine Hoh; D Joshua Cameron; Manjusha Dixit; Zongzhong Tong; Kang Zhang
Further mapping of 10q26 supports strong association of HTRA1 polymorphisms with age-related macular degeneration.
Vision research 2008;48(5):685-9.
2008: Haoyu Chen; Zhenglin Yang; Daniel Gibbs; Xian Yang; Vincent Hau; Peiquan Zhao; Xiang Ma; Jiexi Zeng; Ling Luo; Erik Pearson; Ryan Constantine; Yuuki Kaminoh; Jennifer Harmon; Zongzhong Tong; Charity A Stratton; D Joshua Cameron; Shibo Tang; Kang Zhang
Association of HTRA1 polymorphism and bilaterality in advanced age-related macular degeneration.
Vision research 2008;48(5):690-4.
2008: Zhenglin Yang; Zongzhong Tong; Louis J Chorich; Erik Pearson; Xian Yang; Anthony Moore; David Hunt; Kang Zhang
Clinical characterization and genetic mapping of North Carolina macular dystrophy.
Vision research 2008;48(3):470-7.
2008: D Joshua Cameron; Zhenglin Yang; Zongzhong Tong; Yu Zhao; Alissa Praggastis; Eliot A Brinton; Jennifer Harmon; Yali Chen; Erik Pearson; Paul S Bernstein; Gregory Brinton; Xi Li; Adam Jorgensen; Sara Schneider; Daniel Gibbs; Haoyu Chen; Changguan Wang; Kimberly Howes; Nicola J Camp; Kang Zhang
10q26 is associated with increased risk of age-related macular degeneration in the Utah population.
Advances in experimental medicine and biology 2008;613():253-8.
2007: Fang Lu; Jianbin Hu; Peiquan Zhao; Ying Lin; Yang Yang; Xiaoqi Liu; Yingchuan Fan; Bin Chen; Shihuang Liao; Qiong Du; Chuntao Lei; D Joshua Cameron; Kang Zhang; Zhenglin Yang
HTRA1 variant increases risk to neovascular age-related macular degeneration in Chinese population.
Vision research 2007;47(24):3120-3.
2007: D Joshua Cameron; Zhenglin Yang; Daniel Gibbs; Haoyu Chen; Yuuki Kaminoh; Adam Jorgensen; Jiexi Zeng; Ling Luo; Eric Brinton; Gregory Brinton; John M Brand; Paul S Bernstein; Norman A Zabriskie; Shibo Tang; Ryan Constantine; Zongzhong Tong; Kang Zhang
HTRA1 variant confers similar risks to geographic atrophy and neovascular age-related macular degeneration.
Cell cycle (Georgetown, Tex.) 2007;6(9):1122-5.
2007: Wenmei Li; Yali Chen; D Joshua Cameron; Changguan Wang; Goutam Karan; Zhenglin Yang; Yu Zhao; Erik Pearson; Haoyu Chen; Chuxia Deng; Kimberly Howes; Kang Zhang
Elovl4 haploinsufficiency does not induce early onset retinal degeneration in mice.
Vision research 2007;47(5):714-22.
2007: D Joshua Cameron; Zongzhong Tong; Zhenglin Yang; Jack Kaminoh; Shin Kamiyah; Haoyu Chen; Jiexi Zeng; Yali Chen; Ling Luo; Kang Zhang
Essential role of Elovl4 in very long chain fatty acid synthesis, skin permeability barrier function, and neonatal survival.
International journal of biological sciences 2007;3(2):111-9.
2006: Zhenglin Yang; Nicola J Camp; Hui Sun; Zongzhong Tong; Daniel Gibbs; D Joshua Cameron; Haoyu Chen; Yu Zhao; Erik Pearson; Xi Li; Jeremy Chien; Andrew Dewan; Jennifer Harmon; Paul S Bernstein; Viji Shridhar; Norman A Zabriskie; Josephine Hoh; Kimberly Howes; Kang Zhang
A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration.
Science (New York, N.Y.) 2006;314(5801):992-3.
2006: Bradley J Katz; Yu Zhao; Judith E A Warner; Zongzhong Tong; Zhenglin Yang; Kang Zhang
A family with X-linked optic atrophy linked to the OPA2 locus Xp11.4-Xp11.2.
American journal of medical genetics. Part A 2006;140(20):2207-11.
2006: Zongzhong Tong; Zhenglin Yang; J Jay Meyer; Allen W McInnes; Lai Xue; Asif M Azimi; Jenn Baird; Yu Zhao; Erik Pearson; Changguan Wang; Yali Chen; Kang Zhang
A novel locus for X-linked retinitis pigmentosa.
Annals of the Academy of Medicine, Singapore 2006;35(7):476-8.
2006: Yves Sauvé; Goutam Karan; Zhenglin Yang; Chunmei Li; Jianbin Hu; Kang Zhang
Treatment with carbonic anhydrase inhibitors depresses electroretinogram responsiveness in mice.
Advances in experimental medicine and biology 2006;572():439-46.
2006: Changguang Wang; Jianbin Hu; Paul S Bernstein; Michael P Teske; Marielle Payne; Zhenglin Yang; Chumei Li; David Adams; Jennifer H Baird; Kang Zhang
Intravitreal injection of triamcinolone acetonide for macular edema due to retinitis pigmentosa and other retinal diseases.
Advances in experimental medicine and biology 2006;572():309-14.
2006: Bradley J Katz; Zhenglin Yang; Marielle Payne; Yin Lin; Yu Zhao; Erik Pearson; Shan Duan; Shin Kamaya; Goutam Karan; Kang Zhang
Fundus appearance of choroideremia using optical coherence tomograpy.
Advances in experimental medicine and biology 2006;572():57-61.
2006: Darius M Moshfeghi; Zhenglin Yang; Nathan D Faulkner; Goutam Karan; Sukanya Thirumalaichary; Erik Pearson; Yu Zhao; Thomas Tsai; Kang Zhang
Choroidal neovascularization in patients with adult-onset foveomacular dystrophy caused by mutations in the RDS/peripherin gene.
Advances in experimental medicine and biology 2006;572():35-40.
2006: Kristinn Magnusson; Shan Duan; Haraldur Sigurdsson; Hannes Petursson; Zhenglin Yang; Yu Zhao; Paul S Bernstein; Jian Ge; Fridbert Jonasson; Einar Stefansson; Gudleif Helgadottir; Norman A Zabriskie; Thorlakur Jonsson; Asgeir Bjornsson; Theodora Thorlacius; Palmi V Jonsson; Gudmar Thorleifsson; Augustine Kong; Hreinn Stefansson; Kang Zhang; Kari Stefansson; Jeffrey R Gulcher
CFH Y402H confers similar risk of soft drusen and both forms of advanced AMD.
PLoS medicine 2006;3(1):e5.
2005: Goutam Karan; Concepcion Lillo; Zhenglin Yang; D Joshua Cameron; Kirsten G Locke; Yu Zhao; Sukanya Thirumalaichary; Chunmei Li; David G Birch; Heidi R Vollmer-Snarr; D S Williams; Kang Zhang
Lipofuscin accumulation, abnormal electrophysiology, and photoreceptor degeneration in mutant ELOVL4 transgenic mice: a model for macular degeneration.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(11):4164-9.
2005: Li Jiang; Bradley J Katz; Zhenglin Yang; Yu Zhao; Nathan Faulkner; Jianbin Hu; Jennifer Baird; Wolfgang Baehr; Donnell J Creel; Kang Zhang
Autosomal dominant cone dystrophy caused by a novel mutation in the GCAP1 gene (GUCA1A).
Molecular vision 2005;11():143-51.
2005: Zhenglin Yang; Bernardo V Alvarez; Christina F Chakarova; Li Jiang; Goutam Karan; Jeanne M Frederick; Yu Zhao; Yves Sauvé; Xi Li; Eberhart Zrenner; Bernd Wissinger; Anneke I Den Hollander; Bradley Katz; Wolfgang Baehr; Frans P M Cremers; Joseph R Casey; Shomi S Bhattacharya; Kang Zhang
Mutant carbonic anhydrase 4 impairs pH regulation and causes retinal photoreceptor degeneration.
Human molecular genetics 2005;14(2):255-65.
2005: Goutam Karan; Zhenglin Yang; Kimberly Howes; Yu Zhao; Yali Chen; D Joshua Cameron; Yin Lin; Erik Pearson; Kang Zhang
Loss of ER retention and sequestration of the wild-type ELOVL4 by Stargardt disease dominant negative mutants.
Molecular vision 2005;11():657-64.
2004: Alessandra Maugeri; Françoise Meire; Carel B Hoyng; Carolien Vink; Nicole Van Regemorter; Goutam Karan; Zhenglin Yang; Frans P M Cremers; Kang Zhang
A novel mutation in the ELOVL4 gene causes autosomal dominant Stargardt-like macular dystrophy.
Investigative ophthalmology & visual science 2004;45(12):4263-7.
2004: Marielle Payne; Zhenglin Yang; Bradley J Katz; Judith E A Warner; Christopher J Weight; Yu Zhao; Erik Pearson; Robert L Treft; Todd A Hillman; Richard J Kennedy; Francoise M Meire; Kang Zhang
Dominant optic atrophy, sensorineural hearing loss, ptosis, and ophthalmoplegia: a syndrome caused by a missense mutation in OPA1.
American journal of ophthalmology 2004;138(5):749-55.
2004: Zhenglin Yang; Yang Li; Li Jiang; Goutam Karan; Darius M Moshfeghi; Scott O'Connor; Xi Li; Zhengya Yu; Hilel Lewis; Donald J Zack; Samuel Jacobson; Kang Zhang
A novel RDS/peripherin gene mutation associated with diverse macular phenotypes.
Ophthalmic genetics 2004;25(2):133-45.
2004: Goutam Karan; Zhenglin Yang; Kang Zhang
Expression of wild type and mutant ELOVL4 in cell culture: subcellular localization and cell viability.
Molecular vision 2004;10():248-53.
2003: Xian-Mei Zhang; Zhenglin Yang; Goutam Karan; Takao Hashimoto; Wolfgang Baehr; Xian-Jie Yang; Kang Zhang
Elovl4 mRNA distribution in the developing mouse retina and phylogenetic conservation of Elovl4 genes.
Molecular vision 2003;9():301-7.
2003: Zhenglin Yang; Wei Lin; Darius M Moshfeghi; Sukanya Thirumalaichary; Xi Li; Li Jiang; Heidi Zhang; Sheng Zhang; Peter K Kaiser; Elias Traboulsi; Kang Zhang
A novel mutation in the RDS/Peripherin gene causes adult-onset foveomacular dystrophy.
American journal of ophthalmology 2003;135(2):213-8.
2002: Zhenglin Yang; Neal S Peachey; Darius M Moshfeghi; Sukanya Thirumalaichary; Lou Chorich; Yin Yao Shugart; Keke Fan; Kang Zhang
Mutations in the RPGR gene cause X-linked cone dystrophy.
Human molecular genetics 2002;11(5):605-11.
2001: Radha Ayyagari; Kang Zhang; Amy Hutchinson; Z Yu; Anand Swaroop; Laura E Kakuk; J M Seddon; Paul S Bernstein; R A Lewis; Jaana Tammur; Zhenglin Yang; Yingying Li; H Zhang; Beverly M Yashar; Jiafan Liu; Konstantin Petrukhin; Paul Sieving; Rando Allikmets
Evaluation of the ELOVL4 gene in patients with age-related macular degeneration.
Ophthalmic genetics 2001;22(4):233-9.
2001: Kang Zhang; MF Kniazeva; Min Han; W Li; Z Yu; Zhenglin Yang; Yingying Li; Michael Metzker; Rando Allikmets; Donald J Zack; Laura E Kakuk; Pamela S Lagali; Paul W Wong; Ian M MacDonald; Paul Sieving; David Figueroa; Christopher P Austin; Robert Gould; Radha Ayyagari; Konstantin Petrukhin
A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy.
Nature genetics 2001;27(1):89-93.
2000: Wenyuan Shi; Zhenglin Yang; H Sun; Hope Lancero; L Tong
Phenotypic analyses of frz and dif double mutants of Myxococcus xanthus.
FEMS microbiology letters 2000;192(2):211-5.
2000: Zhenglin Yang; Xiaoyuan Ma; L Tong; Heidi B Kaplan; L J Shimkets; Wenyuan Shi
Myxococcus xanthus dif genes are required for biogenesis of cell surface fibrils essential for social gliding motility.
Journal of bacteriology 2000;182(20):5793-8.
1999: H Sun; Zhenglin Yang; Wenyuan Shi
Effect of cellular filamentation on adventurous and social gliding motility of Myxococcus xanthus.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(26):15178-83.
1998: Zhenglin Yang; Y Geng; D Xu; Heidi B Kaplan; Wenyuan Shi
A new set of chemotaxis homologues is essential for Myxococcus xanthus social motility.
Molecular microbiology 1998;30(5):1123-30.
1998: Y Geng; Zhenglin Yang; J Downard; David R Zusman; Wenyuan Shi
Methylation of FrzCD defines a discrete step in the developmental program of Myxococcus xanthus.
Journal of bacteriology 1998;180(21):5765-8.
1998: Zhenglin Yang; R Delgado; Li Xu; Robert F Todd III; Elizabeth G Nabel; A Sanchez; Gary Nabel
Distinct cellular interactions of secreted and transmembrane Ebola virus glycoproteins.
Science (New York, N.Y.) 1998;279(5353):1034-7.
1998: Wenyuan Shi; Zhenglin Yang; Y Geng; Lawrence E Wolinsky; Michael A Lovett
Chemotaxis in Borrelia burgdorferi.
Journal of bacteriology 1998;180(2):231-5.
1998: Zhenglin Yang; Y Geng; Wenyuan Shi
A DnaK homolog in Myxococcus xanthus is involved in social motility and fruiting body formation.
Journal of bacteriology 1998;180(2):218-24.
1998: Li Xu; A Sanchez; Zhenglin Yang; S R Zaki; Elizabeth G Nabel; Stuart T Nichol; Gary Nabel
Immunization for Ebola virus infection.
Nature medicine 1998;4(1):37-42.