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Bruce Yankner

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Dana Gabuzda; Bruce A Yankner
Physiology: Inflammation links ageing to the brain.
Peter C W Lee; Bruce A Yankner; Liviu Aron; Roderick T Bronson; Jean-Cosme Dodart; Lydia W Finley; Marcia Haigis; J Wade Harper
Altered social behavior and neuronal development in mice lacking the uba6-use1 ubiquitin transfer system.
Marcia C Haigis; Bruce A Yankner
The aging stress response.

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All Publications

2013: Dana Gabuzda; Bruce A Yankner
Physiology: Inflammation links ageing to the brain.
Nature 2013;497(7448):197-8.
2013: Peter C W Lee; Bruce A Yankner; Liviu Aron; Roderick T Bronson; Jean-Cosme Dodart; Lydia W Finley; Marcia Haigis; J Wade Harper
Altered social behavior and neuronal development in mice lacking the uba6-use1 ubiquitin transfer system.
Molecular cell 2013;50(2):172-84.
2010: Marcia C Haigis; Bruce A Yankner
The aging stress response.
Molecular cell 2010;40(2):333-44.
2010: Marta Lipinski; Bin Zheng; Tao Lu; Zhenyu Yan; Benedicte F Py; Aylwin Ng; Ramnik J Xavier; Cheng Li; Bruce A Yankner; Clemens R Scherzer; Junying Yuan
Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(32):14164-9.
2010: Nicholas A Bishop; Tao Lu; Bruce A Yankner
Neural mechanisms of ageing and cognitive decline.
Nature 2010;464(7288):529-35.
2009: Bruce A Yankner; Tao Lu
Amyloid beta-protein toxicity and the pathogenesis of Alzheimer disease.
The Journal of biological chemistry 2009;284(8):4755-9.
2008: Philipp Oberdoerffer; Shaday Michan; Michael McVay; Raul Mostoslavsky; James Vann; Sang-Kyu Park; Andrea Hartlerode; Judith Stegmuller; Angela Hafner; Patrick Loerch; Sarah M Wright; Kevin D Mills; Azad Bonni; Bruce A Yankner; Ralph Scully; Tomas A Prolla; Frederick W Alt; David A Sinclair
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging.
Cell 2008;135(5):907-18.
2008: Sofia Papadia; Francesc X Soriano; Frédéric Léveillé; Marc-Andre Martel; Kelly A Dakin; Henrik H Hansen; Angela Kaindl; Marco Sifringer; Jill Fowler; Vanya Stefovska; Grahame McKenzie; Marie Craigon; Roderick Corriveau; Peter Ghazal; Karen Horsburgh; Bruce A Yankner; David J A Wyllie; Chrysanthy Ikonomidou; Giles E Hardingham
Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses.
Nature neuroscience 2008;11(4):476-87.
2008: Patrick M Loerch; Tao Lu; Kelly A Dakin; James M Vann; Adrian Isaacs; Changiz Geula; Jianbin Wang; Ying Pan; Dana Gabuzda; Cheng Li; Tomas A Prolla; Bruce A Yankner
Evolution of the aging brain transcriptome and synaptic regulation.
PloS one 2008;3(10):e3329.
2008: Bruce A Yankner; Tao Lu; Patrick Loerch
The aging brain.
Annual review of pathology 2008;3():41-66.
2006: Adrian M Isaacs; David B Senn; Menglan Yuan; James P Shine; Bruce A Yankner
Acceleration of amyloid beta-peptide aggregation by physiological concentrations of calcium.
The Journal of biological chemistry 2006;281(38):27916-23.
2006: Mamoru Shibata; Tao Lu; Tsuyoshi Furuya; Alexei Degterev; Noboru Mizushima; Tamotsu Yoshimori; Marcy MacDonald; Bruce A Yankner; Junying Yuan
Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1.
The Journal of biological chemistry 2006;281(20):14474-85.
2005: Matthew R Hass; Bruce A Yankner
A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein.
The Journal of biological chemistry 2005;280(44):36895-904.
2005: Jin Xu; Nan Zhong; Haoyong Wang; Josh Elias; Christina Y Kim; Irina Woldman; Christian Pifl; Steven P Gygi; Changiz Geula; Bruce A Yankner
The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis.
Human molecular genetics 2005;14(9):1231-41.
2004: Tao Lu; Ying Pan; Shyan-Yuan Kao; Cheng Li; Isaac Kohane; Jennifer Chan; Bruce A Yankner
Gene regulation and DNA damage in the ageing human brain.
Nature 2004;429(6994):883-91.
2003: Fusheng Chen; Anurag Tandon; Nobuo Sanjo; Yong-Jun Gu; Hiroshi Hasegawa; Shigeki Arawaka; Frank J S Lee; Xueying Ruan; Peter Mastrangelo; Serap Erdebil; Linda Wang; David Westaway; Howard T J Mount; Bruce A Yankner; Paul E Fraser; Peter St George-Hyslop
Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain.
The Journal of biological chemistry 2003;278(22):19974-9.
2002: Jin Xu; Shyan-Yuan Kao; Frank J S Lee; Weihong Song; Lee-Way Jin; Bruce A Yankner
Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease.
Nature medicine 2002;8(6):600-6.
2002: Julius O Ebinu; Bruce A Yankner
A RIP tide in neuronal signal transduction.
Neuron 2002;34(4):499-502.
2002: Jorge Busciglio; Alejandra Pelsman; Caine Wong; Gustavo Pigino; Menglan Yuan; Hiroshi Mori; Bruce A Yankner
Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome.
Neuron 2002;33(5):677-88.
2000: Junying Yuan; Bruce A Yankner
Apoptosis in the nervous system.
Nature 2000;407(6805):802-9.
2000: Zhuohua Zhang; P Nadeau; W Song; D Donoviel; M Yuan; A Bernstein; Bruce A Yankner
Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1.
Nature cell biology 2000;2(7):463-5.
2000: Alfredo Lorenzo; M Yuan; Zhuohua Zhang; Paolo Paganetti; Christine Sturchler-Pierrat; Matthias Staufenbiel; J Mautino; F S Vigo; Bernd Sommer; Bruce A Yankner
Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease.
Nature neuroscience 2000;3(5):460-4.
2000: Bruce A Yankner
A century of cognitive decline.
Nature 2000;404(6774):125.
2000: T Nakagawa; H Zhu; N Morishima; E Li; J Xu; Bruce A Yankner; Junying Yuan
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta.
Nature 2000;403(6765):98-103.
2000: Bruce A Yankner
The pathogenesis of Alzheimer's disease. Is amyloid beta-protein the beginning or the end?
Annals of the New York Academy of Sciences 2000;924():26-8.
1999: W Song; P Nadeau; M Yuan; X Yang; Jie Shen; Bruce A Yankner
Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(12):6959-63.
1999: Chunming Liu; Y Kato; Zhuohua Zhang; V M Do; Bruce A Yankner; Xi He
beta-Trcp couples beta-catenin phosphorylation-degradation and regulates Xenopus axis formation.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(11):6273-8.
1998: Zhuohua Zhang; H Hartmann; V M Do; Dorothee Abramowski; Christine Sturchler-Pierrat; Matthias Staufenbiel; Bernd Sommer; M van de Wetering; H Clevers; P Saftig; Bart De Strooper; X He; Bruce A Yankner
Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis.
Nature 1998;395(6703):698-702.
1998: Changiz Geula; Chuang-Kuo Wu; DM Saroff; A Lorenzo; M Yuan; Bruce A Yankner
Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity.
Nature medicine 1998;4(7):827-31.
1997: Jorge Busciglio; H Hartmann; Alfredo Lorenzo; C Wong; KH Baumann; Bernd Sommer; Matthias Staufenbiel; Bruce A Yankner
Neuronal localization of presenilin-1 and association with amyloid plaques and neurofibrillary tangles in Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(13):5101-7.
1997: H Hartmann; Jorge Busciglio; KH Baumann; Matthias Staufenbiel; Bruce A Yankner
Developmental regulation of presenilin-1 processing in the brain suggests a role in neuronal differentiation.
The Journal of biological chemistry 1997;272(23):14505-8.
1997: KH Baumann; Paolo Paganetti; Christine Sturchler-Pierrat; C Wong; H Hartmann; R Cescato; Peter Frey; Bruce A Yankner; Bernd Sommer; Matthias Staufenbiel
Distinct processing of endogenous and overexpressed recombinant presenilin 1.
Neurobiology of aging 1997;18(2):181-9.
1996: Bruce A Yankner
New clues to Alzheimer's disease: unraveling the roles of amyloid and tau.
Nature medicine 1996;2(8):850-2.
1996: Bruce A Yankner
Mechanisms of neuronal degeneration in Alzheimer's disease.
Neuron 1996;16(5):921-32.
1996: A Lorenzo; Bruce A Yankner
Amyloid fibril toxicity in Alzheimer's disease and diabetes.
Annals of the New York Academy of Sciences 1996;777():89-95.
1995: Jorge Busciglio; Bruce A Yankner
Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro.
Nature 1995;378(6559):776-9.
1995: B L Martin; G Schrader-Fischer; Jorge Busciglio; M Duke; Paolo Paganetti; Bruce A Yankner
Intracellular accumulation of beta-amyloid in cells expressing the Swedish mutant amyloid precursor protein.
The Journal of biological chemistry 1995;270(45):26727-30.
1995: Jorge Busciglio; A Lorenzo; J Yeh; Bruce A Yankner
beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding.
Neuron 1995;14(4):879-88.
1994: A Lorenzo; Bruce A Yankner
Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(25):12243-7.
1994: Dana Gabuzda; Jorge Busciglio; L B Chen; Paul Matsudaira; Bruce A Yankner
Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative.
The Journal of biological chemistry 1994;269(18):13623-8.
1994: A Lorenzo; B Razzaboni; G C Weir; Bruce A Yankner
Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus.
Nature 1994;368(6473):756-60.
1993: Dana Gabuzda; Jorge Busciglio; Bruce A Yankner
Inhibition of beta-amyloid production by activation of protein kinase C.
Journal of neurochemistry 1993;61(6):2326-9.
1993: Jorge Busciglio; J Yeh; Bruce A Yankner
beta-Amyloid neurotoxicity in human cortical culture is not mediated by excitotoxins.
Journal of neurochemistry 1993;61(4):1565-8.
1993: Jorge Busciglio; Dana Gabuzda; Paul Matsudaira; Bruce A Yankner
Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(5):2092-6.
1992: Bruce A Yankner
Commentary and perspective on studies of beta amyloid neurotoxicity.
Neurobiology of aging 1992;13(5):615-6.
1992: Jorge Busciglio; A Lorenzo; Bruce A Yankner
Methodological variables in the assessment of beta amyloid neurotoxicity.
Neurobiology of aging 1992;13(5):609-12.
1992: M Chen; Paul Tempst; Bruce A Yankner
Secretogranin I/chromogranin B is a heparin-binding adhesive protein.
Journal of neurochemistry 1992;58(5):1691-8.
1991: Bruce A Yankner; Marek-Marsel Mesulam
Seminars in medicine of the Beth Israel Hospital, Boston. beta-Amyloid and the pathogenesis of Alzheimer's disease.
The New England journal of medicine 1991;325(26):1849-57.
1991: Neil W Kowall; M Flint Beal; Jorge Busciglio; L K Duffy; Bruce A Yankner
An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(16):7247-51.
1991: M Chen; Bruce A Yankner
An antibody to beta amyloid and the amyloid precursor protein inhibits cell-substratum adhesion in many mammalian cell types.
Neuroscience letters 1991;125(2):223-6.
1990: Bruce A Yankner; A Caceres; L K Duffy
Nerve growth factor potentiates the neurotoxicity of beta amyloid.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(22):9020-3.
1990: Bruce A Yankner; L K Duffy; Daniel A Kirschner
Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides.
Science (New York, N.Y.) 1990;250(4978):279-82.
1990: Bruce A Yankner; Larry I Benowitz; L Villa-Komaroff; Rachael L Neve
Transfection of PC12 cells with the human GAP-43 gene: effects on neurite outgrowth and regeneration.
Brain research. Molecular brain research 1990;7(1):39-44.
1990: Rachael L Neve; L R Dawes; Bruce A Yankner; Larry I Benowitz; W Rodriguez; Gerry Higgins
Genetics and biology of the Alzheimer amyloid precursor.
Progress in brain research 1990;86():257-67.
1989: Bruce A Yankner
NGF and Alzheimer's disease--considerations and caveats.
Neurobiology of aging 1989;10(5):546-7; discussion 552-3.
1989: Bruce A Yankner
Amyloid and Alzheimer's disease--cause or effect?
Neurobiology of aging 1989;10(5):470-1; discussion 477-8.
1989: Bruce A Yankner; L R Dawes; S Fisher; L Villa-Komaroff; M L Oster-Granite; Rachael L Neve
Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease.
Science (New York, N.Y.) 1989;245(4916):417-20.
1986: Bruce A Yankner; P R Skolnik; G M Shoukimas; Dana Gabuzda; R A Sobel; D D Ho
Cerebral granulomatous angiitis associated with isolation of human T-lymphotropic virus type III from the central nervous system.
Annals of neurology 1986;20(3):362-4.