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Kenneth Brinkhous

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Kenneth Brinkhous; Helena Sandberg; Lars Widlund; Marjorie Read; Timothy C Nichols; Jeffery Sigman; Ulla Oswaldsson; Robert G Schaub; Marianne Mikaelsson
Preclinical pharmacology of albumin-free B-domain deleted recombinant factor VIII.
K McCarthy; P Stewart; Jeffery Sigman; Marjorie Read; James Carl Keith; Kenneth Brinkhous; Timothy C Nichols; R G Schaub
Pharmacokinetics of recombinant factor IX after intravenous and subcutaneous administration in dogs and cynomolgus monkeys.
Richard O Snyder; C Miao; Leonard Meuse; J Tubb; Brian A Donahue; Hui-Feng Lin; Darrel W Stafford; S Patel; Arthur R Thompson; Timothy C Nichols; Marjorie S Read; Dwight A Bellinger; Kenneth Brinkhous; Mark A Kay
Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors.

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All Publications

2002: Kenneth Brinkhous; Helena Sandberg; Lars Widlund; Marjorie Read; Timothy C Nichols; Jeffery Sigman; Ulla Oswaldsson; Robert G Schaub; Marianne Mikaelsson
Preclinical pharmacology of albumin-free B-domain deleted recombinant factor VIII.
Seminars in thrombosis and hemostasis 2002;28(3):269-72.
2002: K McCarthy; P Stewart; Jeffery Sigman; Marjorie Read; James Carl Keith; Kenneth Brinkhous; Timothy C Nichols; R G Schaub
Pharmacokinetics of recombinant factor IX after intravenous and subcutaneous administration in dogs and cynomolgus monkeys.
Thrombosis and haemostasis 2002;87(5):824-30.
1999: Richard O Snyder; C Miao; Leonard Meuse; J Tubb; Brian A Donahue; Hui-Feng Lin; Darrel W Stafford; S Patel; Arthur R Thompson; Timothy C Nichols; Marjorie S Read; Dwight A Bellinger; Kenneth Brinkhous; Mark A Kay
Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors.
Nature medicine 1999;5(1):64-70.
1999: Roland W Herzog; E Y Yang; Linda B Couto; J Nathan Hagstrom; D Elwell; Paul A Fields; M Burton; Dwight A Bellinger; Marjorie S Read; Kenneth Brinkhous; Greg M Podsakoff; Timothy C Nichols; GJ Kurtzman; Katherine A High
Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector.
Nature medicine 1999;5(1):56-63.
1997: Jen-Yea Chang; Dougald M Monroe; Darrel W Stafford; Kenneth Brinkhous; Harold R Roberts
Replacing the first epidermal growth factor-like domain of factor IX with that of factor VII enhances activity in vitro and in canine hemophilia B.
The Journal of clinical investigation 1997;100(4):886-92.
1997: DK Liles; C N Landen; Dougald M Monroe; Celeste Lindley; Marjorie S Read; Harold R Roberts; Kenneth Brinkhous
Extravascular administration of factor IX: potential for replacement therapy of canine and human hemophilia B.
Thrombosis and haemostasis 1997;77(5):944-8.
1996: S V Smith; L Lumeng; Marjorie S Read; Leslie V Parise; Robert L Reddick; J L Sigman; C Boudignon-Proudhon; Jennifer Smith; T K Li; Kenneth Brinkhous
Characterization of a new hereditary thrombopathy in a closed colony of Wistar rats.
The Journal of laboratory and clinical medicine 1996;128(6):601-11.
1996: Kenneth Brinkhous; J L Sigman; Marjorie S Read; P F Stewart; K P McCarthy; G A Timony; S D Leppanen; B J Rup; James Carl Keith; P D Garzone; R G Schaub
Recombinant human factor IX: replacement therapy, prophylaxis, and pharmacokinetics in canine hemophilia B.
Blood 1996;88(7):2603-10.
1996: Bingliang Fang; H Wang; G Gordon; Dwight A Bellinger; Marjorie S Read; Kenneth Brinkhous; SL Woo; Randy C Eisensmith
Lack of persistence of E1- recombinant adenoviral vectors containing a temperature-sensitive E2A mutation in immunocompetent mice and hemophilia B dogs.
Gene therapy 1996;3(3):217-22.
1995: W E Sanders; Robert L Reddick; Timothy C Nichols; Kenneth Brinkhous; Marjorie S Read
Thrombotic thrombocytopenia induced in dogs and pigs. The role of plasma and platelet vWF in animal models of thrombotic thrombocytopenic purpura.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(6):793-800.
1995: Marjorie S Read; Robert L Reddick; A P Bode; Dwight A Bellinger; Timothy C Nichols; K Taylor; S V Smith; D K McMahon; Thomas R Griggs; Kenneth Brinkhous
Preservation of hemostatic and structural properties of rehydrated lyophilized platelets: potential for long-term storage of dried platelets for transfusion.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(2):397-401.
1994: J N Lozier; A R Thompson; P C Hu; M Read; Kenneth Brinkhous; Katherine A High; D T Curiel
Efficient transfection of primary cells in a canine hemophilia B model using adenovirus-polylysine-DNA complexes.
Human gene therapy 1994;5(3):313-22.
1994: J N Lozier; Kenneth Brinkhous
Gene therapy and the hemophilias.
JAMA : the journal of the American Medical Association 1994;271(1):47-51.
1993: Mark A Kay; S Rothenberg; C N Landen; Dwight A Bellinger; F Leland; C Toman; Milton Finegold; Arthur R Thompson; Marjorie S Read; Kenneth Brinkhous
In vivo gene therapy of hemophilia B: sustained partial correction in factor IX-deficient dogs.
Science (New York, N.Y.) 1993;262(5130):117-9.
1993: Timothy C Nichols; Dwight A Bellinger; Robert L Reddick; S V Smith; Gary G Koch; K Davis; J Sigman; Kenneth Brinkhous; Thomas R Griggs; Marjorie S Read
The roles of von Willebrand factor and factor VIII in arterial thrombosis: studies in canine von Willebrand disease and hemophilia A.
Blood 1993;81(10):2644-51.
1992: Kenneth Brinkhous
Gene transfer in the hemophilias: retrospect and prospect.
Thrombosis research 1992;67(3):329-38.
1992: Timothy C Nichols; Dwight A Bellinger; K E Davis; Gary G Koch; Robert L Reddick; Marjorie S Read; J Rapacz; J Hasler-Rapacz; Kenneth Brinkhous; Thomas R Griggs
Porcine von Willebrand disease and atherosclerosis. Influence of polymorphism in apolipoprotein B100 genotype.
The American journal of pathology 1992;140(2):403-15.
1991: S V Smith; Kenneth Brinkhous
Inventory of exogenous platelet-aggregating agent derived from venoms.
Thrombosis and haemostasis 1991;66(2):259-63.
1991: Kenneth Brinkhous; Robert L Reddick; Marjorie S Read; Timothy C Nichols; Dwight A Bellinger; Thomas R Griggs
von Willebrand factor and animal models: contributions to gene therapy, thrombotic thrombocytopenic purpura, and coronary artery thrombosis.
Mayo Clinic proceedings. Mayo Clinic 1991;66(7):733-42.
1991: Timothy C Nichols; Dwight A Bellinger; Robert L Reddick; Marjorie S Read; Gary G Koch; Kenneth Brinkhous; Thomas R Griggs
Role of von Willebrand factor in arterial thrombosis. Studies in normal and von Willebrand disease pigs.
Circulation 1991;83(6 Suppl):IV56-64.
1991: L A Eaton; Marjorie S Read; Kenneth Brinkhous
Glycoprotein Ib bioassays. Activity levels in Bernard-Soulier syndrome and in stored blood bank platelets.
Archives of pathology & laboratory medicine 1991;115(5):488-93.
1990: Robert L Reddick; Marjorie S Read; Kenneth Brinkhous; Dwight A Bellinger; Timothy C Nichols; Thomas R Griggs
Coronary atherosclerosis in the pig. Induced plaque injury and platelet response.
Arteriosclerosis (Dallas, Tex.) 1990;10(4):541-50.
1990: J H Axelrod; Marjorie S Read; Kenneth Brinkhous; Inder M Verma
Phenotypic correction of factor IX deficiency in skin fibroblasts of hemophilic dogs.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(13):5173-7.
1990: Timothy C Nichols; Dwight A Bellinger; DA Tate; Robert L Reddick; Marjorie S Read; Gary G Koch; Kenneth Brinkhous; Thomas R Griggs
von Willebrand factor and occlusive arterial thrombosis. A study in normal and von Willebrand's disease pigs with diet-induced hypercholesterolemia and atherosclerosis.
Arteriosclerosis (Dallas, Tex.) 1990;10(3):449-61.
1989: James P Evans; Kenneth Brinkhous; G D Brayer; Howard Reisner; Katherine A High
Canine hemophilia B resulting from a point mutation with unusual consequences.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(24):10095-9.
1989: Marjorie S Read; S V Smith; M A Lamb; Kenneth Brinkhous
Role of botrocetin in platelet agglutination: formation of an activated complex of botrocetin and von Willebrand factor.
Blood 1989;74(3):1031-5.
1989: Kenneth Brinkhous; U Hedner; J B Garris; V Diness; Marjorie S Read
Effect of recombinant factor VIIa on the hemostatic defect in dogs with hemophilia A, hemophilia B, and von Willebrand disease.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(4):1382-6.
1988: W E Sanders; Marjorie S Read; Robert L Reddick; J B Garris; Kenneth Brinkhous
Thrombotic thrombocytopenia with von Willebrand factor deficiency induced by botrocetin. An animal model.
Laboratory investigation; a journal of technical methods and pathology 1988;59(4):443-52.
1987: Dwight A Bellinger; Timothy C Nichols; Marjorie S Read; Robert L Reddick; M A Lamb; Kenneth Brinkhous; B L Evatt; Thomas R Griggs
Prevention of occlusive coronary artery thrombosis by a murine monoclonal antibody to porcine von Willebrand factor.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(22):8100-4.
1985: Kenneth Brinkhous; H Sandberg; J B Garris; C Mattsson; M Palm; Thomas R Griggs; Marjorie S Read
Purified human factor VIII procoagulant protein: comparative hemostatic response after infusions into hemophilic and von Willebrand disease dogs.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(24):8752-6.
1985: Kenneth Brinkhous; W A Fricke; Marjorie S Read
Determinants of von Willebrand factor activity elicited by ristocetin and botrocetin: studies on a human von Willebrand factor-binding antibody.
Seminars in thrombosis and hemostasis 1985;11(4):337-41.
1985: W A Fricke; Kenneth Brinkhous; J B Garris; Harold R Roberts
Comparison of inhibitory and binding characteristics of an antibody causing acquired von Willebrand syndrome: an assay for von Willebrand factor binding by antibody.
Blood 1985;66(3):562-9.
1983: Kenneth Brinkhous; Marjorie S Read; W A Fricke; R H Wagner
Botrocetin (venom coagglutinin): reaction with a broad spectrum of multimeric forms of factor VIII macromolecular complex.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(5):1463-6.
1983: Marjorie S Read; J Y Potter; Kenneth Brinkhous
Venom coagglutinin for detection of von Willebrand factor activity in animal plasmas.
The Journal of laboratory and clinical medicine 1983;101(1):74-82.
1982: Robert L Reddick; Thomas R Griggs; M A Lamb; Kenneth Brinkhous
Platelet adhesion to damaged coronary arteries: Comparison in normal and von Willebrand disease swine.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(16):5076-9.
1982: D L Sultzer; Kenneth Brinkhous; Robert L Reddick; Thomas R Griggs
Effect of carbon monoxide on atherogenesis in normal pigs and pigs with von Willebrand's disease.
Atherosclerosis 1982;43(2-3):303-9.
1981: Kenneth Brinkhous; D S Barnes; J Y Potter; Marjorie S Read
Von Willebrand syndrome induced by a Bothrops venom factor: bioassay for venom coagglutinin.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(5):3230-4.
1981: Thomas R Griggs; Robert L Reddick; D Sultzer; Kenneth Brinkhous
Susceptibility to atherosclerosis in aortas and coronary arteries of swine with von Willebrand's disease.
The American journal of pathology 1981;102(2):137-45.
1981: Kenneth Brinkhous; Marjorie S Read; Robert L Reddick; Thomas R Griggs
Pathophysiology of platelet-aggregating von Willebrand factor: applications of the venom coagglutinin vWF assay.
Annals of the New York Academy of Sciences 1981;370():191-204.
1980: Kenneth Brinkhous; Marjorie S Read
Use of venom coagglutinin and lyophilized platelets in testing for platelet-aggregating von Willebrand factor.
Blood 1980;55(3):517-20.