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Albert Brinkmann

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Albert O Brinkmann
Molecular mechanisms of androgen action--a historical perspective.
Hao Yun Wong; Jeroen A A Demmers; Karel Bezstarosti; J Anton Grootegoed; Albert O Brinkmann
DNA dependent recruitment of DDX17 and other interacting proteins by the human androgen receptor.
Peter Elfferich; A Z Juniarto; Hendrikus J Dubbink; M E van Royen; Michel Molier; Jos W Hoogerbrugge; Adriaan B Houtsmuller; Jan Trapman; A Santosa; Frank de Jong; Stenvert L S Drop; S M H Faradz; H Bruggenwirth; Albert O Brinkmann
Functional analysis of novel androgen receptor mutations in a unique cohort of Indonesian patients with a disorder of sex development.

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All Publications

2011: Albert O Brinkmann
Molecular mechanisms of androgen action--a historical perspective.
Methods in molecular biology (Clifton, N.J.) 2011;776():3-24.
2009: Hao Yun Wong; Jeroen A A Demmers; Karel Bezstarosti; J Anton Grootegoed; Albert O Brinkmann
DNA dependent recruitment of DDX17 and other interacting proteins by the human androgen receptor.
Biochimica et biophysica acta 2009;1794(2):193-8.
2009: Peter Elfferich; A Z Juniarto; Hendrikus J Dubbink; M E van Royen; Michel Molier; Jos W Hoogerbrugge; Adriaan B Houtsmuller; Jan Trapman; A Santosa; Frank de Jong; Stenvert L S Drop; S M H Faradz; H Bruggenwirth; Albert O Brinkmann
Functional analysis of novel androgen receptor mutations in a unique cohort of Indonesian patients with a disorder of sex development.
Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation 2009;3(5):237-44.
2008: Hao Yun Wong; Jos W Hoogerbrugge; Kar Lok Pang; Marije van Leeuwen; Martin E van Royen; Michel Molier; Cor A Berrevoets; Dennis Dooijes; Hendrikus J Dubbink; Dennis J van de Wijngaart; Katja P Wolffenbuttel; Jan Trapman; Wim J Kleijer; Stenvert L S Drop; J Anton Grootegoed; Albert O Brinkmann
A novel mutation F826L in the human androgen receptor in partial androgen insensitivity syndrome; increased NH2-/COOH-terminal domain interaction and TIF2 co-activation.
Molecular and cellular endocrinology 2008;292(1-2):69-78.
2007: Glenn T G Chang; Simon C Gamble; Mila Jhamai; Robin Wait; Charlotte L Bevan; Albert O Brinkmann
Proteomic analysis of proteins regulated by TRPS1 transcription factor in DU145 prostate cancer cells.
Biochimica et biophysica acta 2007;1774(5):575-82.
2007: Henk Russcher; Virgil A S H Dalm; Frank de Jong; Albert O Brinkmann; Leo J Hofland; Steven W J Lamberts; Jan W Koper
Associations between promoter usage and alternative splicing of the glucocorticoid receptor gene.
Journal of molecular endocrinology 2007;38(1-2):91-8.
2007: pauline smit; Marieke J H J Dekker; Frank de Jong; Annewieke W van den Beld; Jan W Koper; Huibert A P Pols; Albert O Brinkmann; Frank H de Jong; Monique Breteler; Steven W J Lamberts
Lack of Association of the 11beta-hydroxysteroid dehydrogenase type 1 gene 83,557insA and hexose-6-phosphate dehydrogenase gene R453Q polymorphisms with body composition, adrenal androgen production, blood pressure, glucose metabolism, and dementia.
The Journal of clinical endocrinology and metabolism 2007;92(1):359-62.
2006: Hendrikus J Dubbink; Remko Hersmus; Ashley C W Pike; Michel Molier; Albert O Brinkmann; Guido Jenster; Jan Trapman
Androgen receptor ligand-binding domain interaction and nuclear receptor specificity of FXXLF and LXXLL motifs as determined by L/F swapping.
Molecular endocrinology (Baltimore, Md.) 2006;20(8):1742-55.
2006: Erica L T van den Akker; Henk Russcher; Elisabeth F C van Rossum; Albert O Brinkmann; Frank de Jong; Anita Hokken; Huibert A P Pols; Jan W Koper; Steven W J Lamberts
Glucocorticoid receptor polymorphism affects transrepression but not transactivation.
The Journal of clinical endocrinology and metabolism 2006;91(7):2800-3.
2006: Henk Russcher; pauline smit; Elisabeth F C van Rossum; Erica L T van den Akker; Albert O Brinkmann; Loek J M de Heide; Frank de Jong; Jan W Koper; Steven W J Lamberts
Strategies for the characterization of disorders in cortisol sensitivity.
The Journal of clinical endocrinology and metabolism 2006;91(2):694-701.
2005: Antje Hagendorf; Jan W Koper; Frank de Jong; Albert O Brinkmann; Steven W J Lamberts; Richard A Feelders
Expression of the human glucocorticoid receptor splice variants alpha, beta, and P in peripheral blood mononuclear leukocytes in healthy controls and in patients with hyper- and hypocortisolism.
The Journal of clinical endocrinology and metabolism 2005;90(11):6237-43.
2005: Henk Russcher; pauline smit; Erica L T van den Akker; Elisabeth F C van Rossum; Albert O Brinkmann; Frank de Jong; Steven W J Lamberts; Jan W Koper
Two polymorphisms in the glucocorticoid receptor gene directly affect glucocorticoid-regulated gene expression.
The Journal of clinical endocrinology and metabolism 2005;90(10):5804-10.
2005: pauline smit; Ron van Schaik; Marloes van der Werf; Annewieke W van den Beld; Jan W Koper; Jan Lindemans; Huibert A P Pols; Albert O Brinkmann; Frank de Jong; Steven W J Lamberts
A common polymorphism in the CYP3A7 gene is associated with a nearly 50% reduction in serum dehydroepiandrosterone sulfate levels.
The Journal of clinical endocrinology and metabolism 2005;90(9):5313-6.
2005: Henk Russcher; Elisabeth F C van Rossum; Frank de Jong; Albert O Brinkmann; Steven W J Lamberts; Jan W Koper
Increased expression of the glucocorticoid receptor-A translational isoform as a result of the ER22/23EK polymorphism.
Molecular endocrinology (Baltimore, Md.) 2005;19(7):1687-96.
2005: Ellen Smid-Koopman; Liesbeth C M Kuhne; Eline E Hanekamp; Susanne C J P Gielen; Petra E de Ruiter; J Anton Grootegoed; Theo J M Helmerhorst; Curt W Burger; Albert O Brinkmann; Frans J Huikeshoven; Leen J Blok
Progesterone-induced inhibition of growth and differential regulation of gene expression in PRA- and/or PRB-expressing endometrial cancer cell lines.
Journal of the Society for Gynecologic Investigation 2005;12(4):285-92.
2005: pauline smit; Henk Russcher; Frank de Jong; Albert O Brinkmann; Steven W J Lamberts; Jan W Koper
Differential regulation of synthetic glucocorticoids on gene expression levels of glucocorticoid-induced leucine zipper and interleukin-2.
The Journal of clinical endocrinology and metabolism 2005;90(5):2994-3000.
2005: Spiros Vlahopoulos; Warren Zimmer; Guido Jenster; Narasimhaswamy S Belaguli; Steven P Balk; Albert O Brinkmann; Rainer B Lanz; Vassilis C Zoumpourlis; Robert J Schwartz
Recruitment of the androgen receptor via serum response factor facilitates expression of a myogenic gene.
The Journal of biological chemistry 2005;280(9):7786-92.
2005: Arzu Umar; Cor A Berrevoets; N Mai Van; Marije van Leeuwen; Michael Verbiest; Wim J Kleijer; Dennis Dooijes; J Anton Grootegoed; Stenvert L S Drop; Albert O Brinkmann
Functional analysis of a novel androgen receptor mutation, Q902K, in an individual with partial androgen insensitivity.
The Journal of clinical endocrinology and metabolism 2005;90(1):507-15.
2004: Glenn T G Chang; Mila Jhamai; Wytske M Van Weerden; Guido Jenster; Albert O Brinkmann
The TRPS1 transcription factor: androgenic regulation in prostate cancer and high expression in breast cancer.
Endocrine-related cancer 2004;11(4):815-22.
2004: Elisabeth F C van Rossum; Petronella H M Roks; Frank de Jong; Albert O Brinkmann; Huibert A P Pols; Jan W Koper; Steven W J Lamberts
Characterization of a promoter polymorphism in the glucocorticoid receptor gene and its relationship to three other polymorphisms.
Clinical endocrinology 2004;61(5):573-81.
2004: Hao Yun Wong; Jan A Burghoorn; Marije Van Leeuwen; Petra E de Ruiter; Esther Schippers; Leen J Blok; Ka Wan Li; Henk L Dekker; Luitzen de Jong; Jan Trapman; J Anton Grootegoed; Albert O Brinkmann
Phosphorylation of androgen receptor isoforms.
The Biochemical journal 2004;383(Pt 2):267-76.
2004: Hendrikus J Dubbink; Remko Hersmus; chandra verma; Hetty van der Korput; Cor A Berrevoets; Judith van Tol; Angelique C J Ziel-van der Made; Albert O Brinkmann; Ashley C W Pike; Jan Trapman
Distinct recognition modes of FXXLF and LXXLL motifs by the androgen receptor.
Molecular endocrinology (Baltimore, Md.) 2004;18(9):2132-50.
2004: Elisabeth F C van Rossum; Richard A Feelders; Annewieke W van den Beld; André G Uitterlinden; Joop A M J L Janssen; Wietske Ester; Albert O Brinkmann; Diederick Grobbee; Frank de Jong; Huibert A P Pols; Jan W Koper; Steven W J Lamberts
Association of the ER22/23EK polymorphism in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly men.
The American journal of medicine 2004;117(3):158-62.
2004: Ellen Smid-Koopman; Leen J Blok; Theo J M Helmerhorst; Savi Chadha-Ajwani; Curt W Burger; Albert O Brinkmann; Frans J Huikeshoven
Gene expression profiling in human endometrial cancer tissue samples: utility and diagnostic value.
Gynecologic oncology 2004;93(2):292-300.
2004: Cor A Berrevoets; Arzu Umar; Jan Trapman; Albert O Brinkmann
Differential modulation of androgen receptor transcriptional activity by the nuclear receptor co-repressor (N-CoR).
The Biochemical journal 2004;379(Pt 3):731-8.
2004: Kimmo Savinainen; Marika J Linja; Outi Saramäki; Teuvo L J Tammela; Glenn T G Chang; Albert O Brinkmann; Tapio Visakorpi
Expression and copy number analysis of TRPS1, EIF3S3 and MYC genes in breast and prostate cancer.
British journal of cancer 2004;90(5):1041-6.
2003: Gert-Jan C M van den Bemd; Mila Jhamai; Albert O Brinkmann; Glenn T G Chang
The atypical GATA protein TRPS1 represses androgen-induced prostate-specific antigen expression in LNCaP prostate cancer cells.
Biochemical and biophysical research communications 2003;312(3):578-84.
2003: Elisabeth F C van Rossum; Jan W Koper; Annewieke W van den Beld; André G Uitterlinden; Pascal P Arp; Wietske Ester; Joop A M J L Janssen; Albert O Brinkmann; Frank de Jong; Diederick Grobbee; Huibert A P Pols; Steven W J Lamberts
Identification of the BclI polymorphism in the glucocorticoid receptor gene: association with sensitivity to glucocorticoids in vivo and body mass index.
Clinical endocrinology 2003;59(5):585-92.
2003: Arzu Umar; Marja Ooms; Theo M Luider; J Anton Grootegoed; Albert O Brinkmann
Proteomic profiling of epididymis and vas deferens: identification of proteins regulated during rat genital tract development.
Endocrinology 2003;144(10):4637-47.
2003: Eline E Hanekamp; Susanne C J P Gielen; Ellen Smid-Koopman; Liesbeth C M Kühne; Petra E de Ruiter; Savi Chadha-Ajwani; Albert O Brinkmann; J Anton Grootegoed; Curt W Burger; Frans J Huikeshoven; Leen J Blok
Consequences of loss of progesterone receptor expression in development of invasive endometrial cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(11):4190-9.
2003: Josien K Oosterhoff; Fred Penninkhof; Albert O Brinkmann; J Anton Grootegoed; Leen J Blok
REPS2/POB1 is downregulated during human prostate cancer progression and inhibits growth factor signalling in prostate cancer cells.
Oncogene 2003;22(19):2920-5.
2003: Arzu Umar; Theo M Luider; Cor A Berrevoets; J Anton Grootegoed; Albert O Brinkmann
Proteomic analysis of androgen-regulated protein expression in a mouse fetal vas deferens cell line.
Endocrinology 2003;144(4):1147-54.
2003: Ellen Smid-Koopman; Leen J Blok; Liesbeth C M Kühne; Curt W Burger; Theo J M Helmerhorst; Albert O Brinkmann; Frans J Huikeshoven
Distinct functional differences of human progesterone receptors A and B on gene expression and growth regulation in two endometrial carcinoma cell lines.
Journal of the Society for Gynecologic Investigation 2003;10(1):49-57.
2002: Cor A Berrevoets; Arzu Umar; Albert O Brinkmann
Antiandrogens: selective androgen receptor modulators.
Molecular and cellular endocrinology 2002;198(1-2):97-103.
2002: Karine Steketee; Cor A Berrevoets; Hendrikus J Dubbink; Paul Doesburg; Remko Hersmus; Albert O Brinkmann; Jan Trapman
Amino acids 3-13 and amino acids in and flanking the 23FxxLF27 motif modulate the interaction between the N-terminal and ligand-binding domain of the androgen receptor.
European journal of biochemistry / FEBS 2002;269(23):5780-91.
2002: Eline E Hanekamp; E C M Kühne; Ellen Smid-Koopman; Petra E de Ruiter; Savi Chadha-Ajwani; Albert O Brinkmann; Curt W Burger; J Anton Grootegoed; Frans J Huikeshoven; Leen J Blok
Loss of progesterone receptor may lead to an invasive phenotype in human endometrial cancer.
European journal of cancer (Oxford, England : 1990) 2002;38 Suppl 6():S71-2.
2002: Elisabeth F C van Rossum; Jan W Koper; Nannette A T M Huizenga; André G Uitterlinden; Joop A M J L Janssen; Albert O Brinkmann; Diederick Grobbee; Frank de Jong; Cornelia M van Duyn; Huibert A P Pols; Steven W J Lamberts
A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels.
Diabetes 2002;51(10):3128-34.
2002: Karine Steketee; Leon Timmerman; Angelique C J Ziel-van der Made; Paul Doesburg; Albert O Brinkmann; Jan Trapman
Broadened ligand responsiveness of androgen receptor mutants obtained by random amino acid substitution of H874 and mutation hot spot T877 in prostate cancer.
International journal of cancer. Journal international du cancer 2002;100(3):309-17.
2002: Glenn T G Chang; Gert-Jan C M van den Bemd; Mila Jhamai; Albert O Brinkmann
Structure and function of GC79/TRPS1, a novel androgen-repressible apoptosis gene.
Apoptosis : an international journal on programmed cell death 2002;7(1):13-21.
2001: Annemie L M Boehmer; Albert O Brinkmann; Martinus F Niermeijer; D J J Halley; Stenvert L S Drop
[From gene to disease; androgen receptor gene, androgen insensitivity syndrome, and spinal and bulbar muscle atrophy].
Nederlands tijdschrift voor geneeskunde 2001;145(48):2326-8.
2001: Paul-Martin Holterhus; Hennie T Brüggenwirth; Albert O Brinkmann; Olaf Hiort
Post-zygotic mutations and somatic mosaicism in androgen insensitivity syndrome.
Trends in genetics : TIG 2001;17(11):627-8.
2001: Glenn T G Chang; M Steenbeek; Esther Schippers; Leen J Blok; Wytske M Van Weerden; Dirk C van Alewijk; Bert H J Eussen; Gert J van Steenbrugge; Albert O Brinkmann
A novel gene on human chromosome 2p24 is differentially expressed between androgen-dependent and androgen-independent prostate cancer cells.
European journal of cancer (Oxford, England : 1990) 2001;37(16):2129-34.
2001: Albert O Brinkmann
Molecular basis of androgen insensitivity.
Molecular and cellular endocrinology 2001;179(1-2):105-9.
2001: P de Lange; Christine M Segeren; Jan W Koper; E Wiemer; Pieter Sonneveld; Albert O Brinkmann; A White; I J Brogan; Frank de Jong; Steven W J Lamberts
Expression in hematological malignancies of a glucocorticoid receptor splice variant that augments glucocorticoid receptor-mediated effects in transfected cells.
Cancer research 2001;61(10):3937-41.
2001: Annemie L M Boehmer; Rien J M Nijman; B A Lammers; S J de Coninck; JO van Hemel; A P Themmen; M A Mureau; Frank de Jong; Albert O Brinkmann; Martinus F Niermeijer; Stenvert L S Drop
Etiological studies of severe or familial hypospadias.
The Journal of urology 2001;165(4):1246-54.
2001: Annemie L M Boehmer; Albert O Brinkmann; Rien J M Nijman; MC Verleun-Mooijman; Petra E de Ruiter; Martinus F Niermeijer; Stenvert L S Drop
Phenotypic variation in a family with partial androgen insensitivity syndrome explained by differences in 5alpha dihydrotestosterone availability.
The Journal of clinical endocrinology and metabolism 2001;86(3):1240-6.
2000: JM Emmen; Anke McLuskey; Ibrahim M Adham; Wolfgang Engel; J Anton Grootegoed; Albert O Brinkmann
Hormonal control of gubernaculum development during testis descent: gubernaculum outgrowth in vitro requires both insulin-like factor and androgen.
Endocrinology 2000;141(12):4720-7.
2000: Glenn T G Chang; M Steenbeek; Esther Schippers; Leen J Blok; Wytske M Van Weerden; Dirk C van Alewijk; Bert H J Eussen; Gert J van Steenbrugge; Albert O Brinkmann
Characterization of a zinc-finger protein and its association with apoptosis in prostate cancer cells.
Journal of the National Cancer Institute 2000;92(17):1414-21.
2000: Ellen Smid-Koopman; Leen J Blok; Savi Chadha-Ajwani; Theo J M Helmerhorst; Albert O Brinkmann; Frans J Huikeshoven
Gene expression profiles of human endometrial cancer samples using a cDNA-expression array technique: assessment of an analysis method.
British journal of cancer 2000;83(2):246-51.
2000: Nannette A T M Huizenga; Wouter W de Herder; Jan W Koper; P de Lange; A J v D Lely; Albert O Brinkmann; Frank de Jong; Steven W J Lamberts
Decreased ligand affinity rather than glucocorticoid receptor down-regulation in patients with endogenous Cushing's syndrome.
European journal of endocrinology / European Federation of Endocrine Societies 2000;142(5):472-6.
2000: JM Emmen; Anke McLuskey; Ibrahim M Adham; Wolfgang Engel; Miriam Verhoef-Post; Axel P N Themmen; J Anton Grootegoed; Albert O Brinkmann
Involvement of insulin-like factor 3 (Insl3) in diethylstilbestrol-induced cryptorchidism.
Endocrinology 2000;141(2):846-9.
2000: Albert O Brinkmann; J Trapman
Genetic analysis of androgen receptors in development and disease.
Advances in pharmacology (San Diego, Calif.) 2000;47():317-41.
1999: Annemie L M Boehmer; Albert O Brinkmann; L A Sandkuijl; D J J Halley; Martinus F Niermeijer; A S Andersson; Frank de Jong; Hulya Kayserili; M A de Vroede; Barto J Otten; Catrienus W Rouwé; B B Mendonça; C Rodrigues; H H Bode; Petra E de Ruiter; Henriette A Delemarre-Van De Waal; Stenvert L S Drop
17Beta-hydroxysteroid dehydrogenase-3 deficiency: diagnosis, phenotypic variability, population genetics, and worldwide distribution of ancient and de novo mutations.
The Journal of clinical endocrinology and metabolism 1999;84(12):4713-21.
1999: Paul-Martin Holterhus; J Wiebel; G H G Sinnecker; Hennie T Brüggenwirth; Wolfgang G Sippell; Albert O Brinkmann; K Kruse; Olaf Hiort
Clinical and molecular spectrum of somatic mosaicism in androgen insensitivity syndrome.
Pediatric research 1999;46(6):684-90.
1999: Glenn T G Chang; N Tapsi; M Steenbeek; Leen J Blok; Wytske M Van Weerden; Dirk C van Alewijk; Bert H J Eussen; Gert J van Steenbrugge; Albert O Brinkmann
Identification of a gene on human chromosome 8q11 that is differentially expressed during prostate-cancer progression.
International journal of cancer. Journal international du cancer 1999;83(4):506-11.
1999: Leen J Blok; Glenn T G Chang; M Steenbeek-Slotboom; Wytske M Van Weerden; Herman G P Swarts; Jan Joep H H M de Pont; Gert J van Steenbrugge; Albert O Brinkmann
Regulation of expression of Na+,K+-ATPase in androgen-dependent and androgen-independent prostate cancer.
British journal of cancer 1999;81(1):28-36.
1999: P de Lange; Jan W Koper; Albert O Brinkmann; Frank de Jong; Steven W J Lamberts
Natural variants of the beta isoform of the human glucocorticoid receptor do not alter sensitivity to glucocorticoids.
Molecular and cellular endocrinology 1999;153(1-2):163-8.
1999: S Zimmermann; Gerd Steding; JM Emmen; Albert O Brinkmann; Karim Nayernia; A F Holstein; Wolfgang Engel; Ibrahim M Adham
Targeted disruption of the Insl3 gene causes bilateral cryptorchidism.
Molecular endocrinology (Baltimore, Md.) 1999;13(5):681-91.
1999: Albert O Brinkmann; Leen J Blok; Petra E de Ruiter; Paul Doesburg; Karine Steketee; Cor A Berrevoets; Jan Trapman
Mechanisms of androgen receptor activation and function.
The Journal of steroid biochemistry and molecular biology 1999;69(1-6):307-13.
1999: E Koopman; Leen J Blok; Albert O Brinkmann; Theo J M Helmerhorst; Frans J Huikeshoven
Differential gene expression in progesterone-sensitive and progesterone-insensitive endometrial carcinoma cells.
European journal of obstetrics, gynecology, and reproductive biology 1999;82(2):135-8.
1998: Cor A Berrevoets; Paul Doesburg; Karine Steketee; Jan Trapman; Albert O Brinkmann
Functional interactions of the AF-2 activation domain core region of the human androgen receptor with the amino-terminal domain and with the transcriptional coactivator TIF2 (transcriptional intermediary factor2).
Molecular endocrinology (Baltimore, Md.) 1998;12(8):1172-83.
1998: JM Emmen; Anke McLuskey; J Anton Grootegoed; Albert O Brinkmann
Androgen action during male sex differentiation includes suppression of cranial suspensory ligament development.
Human reproduction (Oxford, England) 1998;13(5):1272-80.
1998: Leen J Blok; Petra E de Ruiter; Albert O Brinkmann
Forskolin-induced dephosphorylation of the androgen receptor impairs ligand binding.
Biochemistry 1998;37(11):3850-7.
1998: Nannette A T M Huizenga; P de Lange; Jan W Koper; R N Clayton; W E Farrell; Aart Jan Van der Lely; Albert O Brinkmann; Frank de Jong; Steven W J Lamberts
Human adrenocorticotropin-secreting pituitary adenomas show frequent loss of heterozygosity at the glucocorticoid receptor gene locus.
The Journal of clinical endocrinology and metabolism 1998;83(3):917-21.
1998: M M Verheggen; P W Adriaansen-Soeting; Cor A Berrevoets; PT van Hal; Albert O Brinkmann; Henk C Hoogsteden; Marjan A Versnel
Glucocorticoid receptor expression in human bronchial epithelial cells: effects of smoking and COPD.
Mediators of inflammation 1998;7(4):275-81.
1998: Nannette A T M Huizenga; Jan W Koper; P de Lange; Huibert A P Pols; RP Stolk; H Burger; Diederick Grobbee; Albert O Brinkmann; Frank de Jong; Steven W J Lamberts
A polymorphism in the glucocorticoid receptor gene may be associated with and increased sensitivity to glucocorticoids in vivo.
The Journal of clinical endocrinology and metabolism 1998;83(1):144-51.
1998: Hennie T Brüggenwirth; Annemie L M Boehmer; Jean-Marc Lobaccaro; L Chiche; Charles Sultan; Jan Trapman; Albert O Brinkmann
Substitution of Ala564 in the first zinc cluster of the deoxyribonucleic acid (DNA)-binding domain of the androgen receptor by Asp, Asn, or Leu exerts differential effects on DNA binding.
Endocrinology 1998;139(1):103-10.
1997: C B Cleutjens; Karine Steketee; C C van Eekelen; Hetty van der Korput; Albert O Brinkmann; Jan Trapman
Both androgen receptor and glucocorticoid receptor are able to induce prostate-specific antigen expression, but differ in their growth-stimulating properties of LNCaP cells.
Endocrinology 1997;138(12):5293-300.
1997: Paul-Martin Holterhus; Hennie T Brüggenwirth; Olaf Hiort; A Kleinkauf-Houcken; K Kruse; G H G Sinnecker; Albert O Brinkmann
Mosaicism due to a somatic mutation of the androgen receptor gene determines phenotype in androgen insensitivity syndrome.
The Journal of clinical endocrinology and metabolism 1997;82(11):3584-9.
1997: Hennie T Brüggenwirth; Annemie L M Boehmer; S Ramnarain; MC Verleun-Mooijman; D P Satijn; Jan Trapman; J Anton Grootegoed; Albert O Brinkmann
Molecular analysis of the androgen-receptor gene in a family with receptor-positive partial androgen insensitivity: an unusual type of intronic mutation.
American journal of human genetics 1997;61(5):1067-77.
1997: Glenn T G Chang; Leen J Blok; M Steenbeek; J Veldscholte; Wytske M Van Weerden; Gert J van Steenbrugge; Albert O Brinkmann
Differentially expressed genes in androgen-dependent and -independent prostate carcinomas.
Cancer research 1997;57(18):4075-81.
1997: P de Lange; Jan W Koper; Nannette A T M Huizenga; Albert O Brinkmann; Frank de Jong; Michael Karl; George Chrousos; Steven W J Lamberts
Differential hormone-dependent transcriptional activation and -repression by naturally occurring human glucocorticoid receptor variants.
Molecular endocrinology (Baltimore, Md.) 1997;11(8):1156-64.
1997: Jan W Koper; RP Stolk; P de Lange; Nannette A T M Huizenga; G J Molijn; Huibert A P Pols; Diederick Grobbee; Michael Karl; Frank de Jong; Albert O Brinkmann; Steven W J Lamberts
Lack of association between five polymorphisms in the human glucocorticoid receptor gene and glucocorticoid resistance.
Human genetics 1997;99(5):663-8.
1997: Annemie L M Boehmer; Albert O Brinkmann; Martinus F Niermeijer; L Bakker; D J J Halley; Stenvert L S Drop
Germ-line and somatic mosaicism in the androgen insensitivity syndrome: implications for genetic counseling.
American journal of human genetics 1997;60(4):1003-6.
1997: Paul Doesburg; cor kuil; Cor A Berrevoets; Karine Steketee; P W Faber; E Mulder; Albert O Brinkmann; Jan Trapman
Functional in vivo interaction between the amino-terminal, transactivation domain and the ligand binding domain of the androgen receptor.
Biochemistry 1997;36(5):1052-64.
1997: JH van Roijen; Marja Ooms; R F A Weber; Albert O Brinkmann; J Anton Grootegoed; Jan Vreeburg
Comparison of the response of rat testis and accessory sex organs to treatment with testosterone and the synthetic androgen methyltrienolone (R1881).
Journal of andrology 1997;18(1):51-61.
1996: Wolfgang Weidemann; B Linck; H Haupt; B Mentrup; Gabriela Romalo; K Stockklauser; Albert O Brinkmann; Hans-Udo Schweikert; Klaus-Dieter Spindler
Clinical and biochemical investigations and molecular analysis of subjects with mutations in the androgen receptor gene.
Clinical endocrinology 1996;45(6):733-9.
1996: M M Verheggen; PT van Hal; P W Adriaansen-Soeting; B J Goense; Henk C Hoogsteden; Albert O Brinkmann; Marjan A Versnel
Modulation of glucocorticoid receptor expression in human bronchial epithelial cell lines by IL-1 beta, TNF-alpha and LPS.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1996;9(10):2036-43.
1996: Hennie T Brüggenwirth; Annemie L M Boehmer; M C Verleun-Mooijman; Theo Hoogenboezem; W J Kleijer; B J Otten; Jan Trapman; Albert O Brinkmann
Molecular basis of androgen insensitivity.
The Journal of steroid biochemistry and molecular biology 1996;58(5-6):569-75.
1996: Leen J Blok; Petra E de Ruiter; Albert O Brinkmann
Androgen receptor phosphorylation.
Endocrine research 1996;22(3):197-219.
1996: Kitty B J M Cleutjens; C C van Eekelen; Hetty van der Korput; Albert O Brinkmann; Jan Trapman
Two androgen response regions cooperate in steroid hormone regulated activity of the prostate-specific antigen promoter.
The Journal of biological chemistry 1996;271(11):6379-88.
1996: cor kuil; Albert O Brinkmann
Androgens, antiandrogens and androgen receptor abnormalities.
European urology 1996;29 Suppl 2():78-82.
1995: F M Bentvelsen; Albert O Brinkmann; P van der Schoot; J E van der Linden; Theo Van der Kwast; Wim J A Boersma; Fritz H Schröder; Rien J M Nijman
Developmental pattern and regulation by androgens of androgen receptor expression in the urogenital tract of the rat.
Molecular and cellular endocrinology 1995;113(2):245-53.
1995: F M Bentvelsen; Albert O Brinkmann; J E van der Linden; Fritz H Schröder; Rien J M Nijman
Decreased immunoreactive androgen receptor levels are not the cause of isolated hypospadias.
British journal of urology 1995;76(3):384-8.
1995: G J Molijn; Jan W Koper; C J van Uffelen; Frank de Jong; Albert O Brinkmann; Hajo A Bruining; Steven W J Lamberts
Temperature-induced down-regulation of the glucocorticoid receptor in peripheral blood mononuclear leucocyte in patients with sepsis or septic shock.
Clinical endocrinology 1995;43(2):197-203.
1995: G J Molijn; J J Spek; J C van Uffelen; Frank de Jong; Albert O Brinkmann; Hajo A Bruining; Steven W J Lamberts; Jan W Koper
Differential adaptation of glucocorticoid sensitivity of peripheral blood mononuclear leukocytes in patients with sepsis or septic shock.
The Journal of clinical endocrinology and metabolism 1995;80(6):1799-803.
1995: Albert O Brinkmann; G Jenster; C Ris-Stalpers; Hetty van der Korput; Hennie T Brüggenwirth; Annemie L M Boehmer; Jan Trapman
Androgen receptor mutations.
The Journal of steroid biochemistry and molecular biology 1995;53(1-6):443-8.
1995: Petra E de Ruiter; R Teuwen; Jan Trapman; R Dijkema; Albert O Brinkmann
Synergism between androgens and protein kinase-C on androgen-regulated gene expression.
Molecular and cellular endocrinology 1995;110(1-2):R1-6.
1995: G Jenster; Hetty van der Korput; Jan Trapman; Albert O Brinkmann
Identification of two transcription activation units in the N-terminal domain of the human androgen receptor.
The Journal of biological chemistry 1995;270(13):7341-6.
1995: George G J M Kuiper; Albert O Brinkmann
Phosphotryptic peptide analysis of the human androgen receptor: detection of a hormone-induced phosphopeptide.
Biochemistry 1995;34(6):1851-7.
1994: G Jenster; Petra E de Ruiter; Hetty van der Korput; George G J M Kuiper; Jan Trapman; Albert O Brinkmann
Changes in the abundance of androgen receptor isotypes: effects of ligand treatment, glutamine-stretch variation, and mutation of putative phosphorylation sites.
Biochemistry 1994;33(47):14064-72.
1994: Albert O Brinkmann
Steroid hormone receptors: activators of gene transcription.
The Journal of pediatric endocrinology 1994;7(4):275-82.
1994: P J Janssen; Albert O Brinkmann; Wim J A Boersma; Theo Van der Kwast
Immunohistochemical detection of the androgen receptor with monoclonal antibody F39.4 in routinely processed, paraffin-embedded human tissues after microwave pre-treatment.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1994;42(8):1169-75.
1994: C Ris-Stalpers; M C Verleun-Mooijman; T J de Blaeij; H J Degenhart; Jan Trapman; Albert O Brinkmann
Differential splicing of human androgen receptor pre-mRNA in X-linked Reifenstein syndrome, because of a deletion involving a putative branch site.
American journal of human genetics 1994;54(4):609-17.
1994: George G J M Kuiper; Albert O Brinkmann
Steroid hormone receptor phosphorylation: is there a physiological role?
Molecular and cellular endocrinology 1994;100(1-2):103-7.
1994: J A Ruizeveld de Winter; P J Janssen; H M Sleddens; M C Verleun-Mooijman; Jan Trapman; Albert O Brinkmann; A B Santerse; Fritz H Schröder; Theo Van der Kwast
Androgen receptor status in localized and locally progressive hormone refractory human prostate cancer.
The American journal of pathology 1994;144(4):735-46.
1993: George G J M Kuiper; Petra E de Ruiter; Jan Trapman; G Jenster; Albert O Brinkmann
In vitro translation of androgen receptor cRNA results in an activated androgen receptor protein.
The Biochemical journal 1993;296 ( Pt 1)():161-7.
1993: C Ris-Stalpers; M C Verleun-Mooijman; Jan Trapman; Albert O Brinkmann
Threonine on amino acid position 868 in the human androgen receptor is essential for androgen binding specificity and functional activity.
Biochemical and biophysical research communications 1993;196(1):173-80.
1993: G Jenster; Jan Trapman; Albert O Brinkmann
Nuclear import of the human androgen receptor.
The Biochemical journal 1993;293 ( Pt 3)():761-8.
1993: Jan Trapman; Albert O Brinkmann
Mutations in the androgen receptor.
Annals of the New York Academy of Sciences 1993;684():85-93.
1993: C Ris-Stalpers; A Turberg; M C Verleun-Mooyman; Gabriela Romalo; Hans-Udo Schweikert; Jan Trapman; Albert O Brinkmann
Expression of an aberrantly spliced androgen receptor mRNA in a family with complete androgen insensitivity.
Annals of the New York Academy of Sciences 1993;684():239-42.
1993: George G J M Kuiper; Petra E de Ruiter; Albert O Brinkmann
Androgen receptor phosphorylation.
Annals of the New York Academy of Sciences 1993;684():224-6.
1993: P W Faber; H C van Rooij; H J Schipper; Albert O Brinkmann; Jan Trapman
Two different, overlapping pathways of transcription initiation are active on the TATA-less human androgen receptor promoter. The role of Sp1.
The Journal of biological chemistry 1993;268(13):9296-301.
1993: George G J M Kuiper; Petra E de Ruiter; Jan Trapman; W J Boersma; J Anton Grootegoed; Albert O Brinkmann
Localization and hormonal stimulation of phosphorylation sites in the LNCaP-cell androgen receptor.
The Biochemical journal 1993;291 ( Pt 1)():95-101.
1992: J A Ruizeveld de Winter; Wytske M Van Weerden; P W Faber; Gert J van Steenbrugge; Jan Trapman; Albert O Brinkmann; Theo Van der Kwast
Regulation of androgen receptor expression in the human heterotransplantable prostate carcinoma PC-82.
Endocrinology 1992;131(6):3045-50.
1992: Leen J Blok; J M Bartlett; J Bolt-De Vries; Axel P N Themmen; Albert O Brinkmann; Gerhard Weinbauer; E Nieschlag; J Anton Grootegoed
Effect of testosterone deprivation on expression of the androgen receptor in rat prostate, epididymis and testis.
International journal of andrology 1992;15(2):182-98.
1992: J Veldscholte; Cor A Berrevoets; Albert O Brinkmann; J Anton Grootegoed; E Mulder
Anti-androgens and the mutated androgen receptor of LNCaP cells: differential effects on binding affinity, heat-shock protein interaction, and transcription activation.
Biochemistry 1992;31(8):2393-9.
1992: George G J M Kuiper; Petra E de Ruiter; Albert O Brinkmann
Androgen receptor heterogeneity in LNCaP cells is caused by a hormone independent phosphorylation step.
The Journal of steroid biochemistry and molecular biology 1992;41(3-8):697-700.
1992: G Jenster; Hetty van der Korput; Jan Trapman; Albert O Brinkmann
Functional domains of the human androgen receptor.
The Journal of steroid biochemistry and molecular biology 1992;41(3-8):671-5.
1992: J Veldscholte; Cor A Berrevoets; C Ris-Stalpers; George G J M Kuiper; G Jenster; Jan Trapman; Albert O Brinkmann; E Mulder
The androgen receptor in LNCaP cells contains a mutation in the ligand binding domain which affects steroid binding characteristics and response to antiandrogens.
The Journal of steroid biochemistry and molecular biology 1992;41(3-8):665-9.
1992: Albert O Brinkmann; G Jenster; George G J M Kuiper; C Ris; J H van Laar; Hetty van der Korput; H J Degenhart; Mark Trifiro; Leonard Pinsky; Gabriela Romalo
The human androgen receptor: structure/function relationship in normal and pathological situations.
The Journal of steroid biochemistry and molecular biology 1992;41(3-8):361-8.
1992: Theo Van der Kwast; N D Zegers; G Jenster; W Boersma; Albert O Brinkmann; Jan Trapman
Multi-assay performance of a monoclonal antibody directed against the androgen receptor.
Progress in histochemistry and cytochemistry 1992;26(1-4):61-7.
1991: P H Riegman; R J Vlietstra; Hetty van der Korput; Albert O Brinkmann; Jan Trapman
The promoter of the prostate-specific antigen gene contains a functional androgen responsive element.
Molecular endocrinology (Baltimore, Md.) 1991;5(12):1921-30.
1991: G Jenster; Hetty van der Korput; C van Vroonhoven; Theo Van der Kwast; Jan Trapman; Albert O Brinkmann
Domains of the human androgen receptor involved in steroid binding, transcriptional activation, and subcellular localization.
Molecular endocrinology (Baltimore, Md.) 1991;5(10):1396-404.
1991: George G J M Kuiper; Petra E de Ruiter; J Anton Grootegoed; Albert O Brinkmann
Synthesis and post-translational modification of the androgen receptor in LNCaP cells.
Molecular and cellular endocrinology 1991;80(1-3):65-73.
1991: P W Faber; A King; H C van Rooij; Albert O Brinkmann; NJ de Both; Jan Trapman
The mouse androgen receptor. Functional analysis of the protein and characterization of the gene.
The Biochemical journal 1991;278 ( Pt 1)():269-78.
1991: P W Faber; H C van Rooij; Hetty van der Korput; Willy M Baarends; Albert O Brinkmann; J Anton Grootegoed; Jan Trapman
Characterization of the human androgen receptor transcription unit.
The Journal of biological chemistry 1991;266(17):10743-9.
1991: J H van Laar; Cor A Berrevoets; Jan Trapman; N D Zegers; Albert O Brinkmann
Hormone-dependent androgen receptor phosphorylation is accompanied by receptor transformation in human lymph node carcinoma of the prostate cells.
The Journal of biological chemistry 1991;266(6):3734-8.
1991: N D Zegers; E Claassen; C Neelen; E Mulder; J H van Laar; M M Voorhorst; Cor A Berrevoets; Albert O Brinkmann; Theo Van der Kwast; J A Ruizeveld de Winter
Epitope prediction and confirmation for the human androgen receptor: generation of monoclonal antibodies for multi-assay performance following the synthetic peptide strategy.
Biochimica et biophysica acta 1991;1073(1):23-32.
1991: Albert O Brinkmann; George G J M Kuiper; C Ris-Stalpers; H C van Rooij; Gabriela Romalo; Mark Trifiro; E Mulder; Leonard Pinsky; Hans-Udo Schweikert; Jan Trapman
Androgen receptor abnormalities.
The Journal of steroid biochemistry and molecular biology 1991;40(1-3):349-52.
1991: L J Block; J M Bartlett; J Bolt-de Vries; Axel P N Themmen; Albert O Brinkmann; Gerhard Weinbauer; E Nieschlag; J Anton Grootegoed
Regulation of androgen receptor mRNA and protein in the rat testis by testosterone.
The Journal of steroid biochemistry and molecular biology 1991;40(1-3):343-7.
1990: Jan Trapman; C Ris-Stalpers; Hetty van der Korput; George G J M Kuiper; P W Faber; Johannes C Romijn; E Mulder; Albert O Brinkmann
The androgen receptor: functional structure and expression in transplanted human prostate tumors and prostate tumor cell lines.
The Journal of steroid biochemistry and molecular biology 1990;37(6):837-42.
1990: J Veldscholte; C Ris-Stalpers; George G J M Kuiper; G Jenster; Cor A Berrevoets; E Claassen; H C van Rooij; Jan Trapman; Albert O Brinkmann; E Mulder
A mutation in the ligand binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to anti-androgens.
Biochemical and biophysical research communications 1990;173(2):534-40.
1990: Willy M Baarends; Axel P N Themmen; Leen J Blok; P Mackenbach; Albert O Brinkmann; Dies Meijer; P W Faber; Jan Trapman; J Anton Grootegoed
The rat androgen receptor gene promoter.
Molecular and cellular endocrinology 1990;74(1):75-84.
1990: C Ris-Stalpers; George G J M Kuiper; P W Faber; Hans-Udo Schweikert; H C van Rooij; N D Zegers; M B Hodgins; H J Degenhart; Jan Trapman; Albert O Brinkmann
Aberrant splicing of androgen receptor mRNA results in synthesis of a nonfunctional receptor protein in a patient with androgen insensitivity.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(20):7866-70.
1990: J H van Laar; J Bolt-de Vries; N D Zegers; Jan Trapman; Albert O Brinkmann
Androgen receptor heterogeneity and phosphorylation in human LNCaP cells.
Biochemical and biophysical research communications 1990;166(1):193-200.
1989: J H van Laar; J Bolt-de Vries; M M Voorhorst-Ogink; Albert O Brinkmann
The human androgen receptor is a 110 kDa protein.
Molecular and cellular endocrinology 1989;63(1-2):39-44.
1989: George G J M Kuiper; P W Faber; H C van Rooij; Hetty van der Korput; C Ris-Stalpers; P Klaassen; Jan Trapman; Albert O Brinkmann
Structural organization of the human androgen receptor gene.
Journal of molecular endocrinology 1989;2(3):R1-4.
1989: Leen J Blok; P Mackenbach; Jan Trapman; Axel P N Themmen; Albert O Brinkmann; J Anton Grootegoed
Follicle-stimulating hormone regulates androgen receptor mRNA in Sertoli cells.
Molecular and cellular endocrinology 1989;63(1-2):267-71.
1989: P W Faber; George G J M Kuiper; H C van Rooij; Hetty van der Korput; Albert O Brinkmann; Jan Trapman
The N-terminal domain of the human androgen receptor is encoded by one, large exon.
Molecular and cellular endocrinology 1989;61(2):257-62.
1989: Albert O Brinkmann; P Klaasen; George G J M Kuiper; Hetty van der Korput; J Bolt; W de Boer; A Smit; P W Faber; H C van Rooij; A Geurts van Kessel
Structure and function of the androgen receptor.
Urological research 1989;17(2):87-93.
1989: E Mulder; D van Loon; W de Boer; A L Schuurmans; J Bolt; M M Voorhorst; George G J M Kuiper; Albert O Brinkmann
Mechanism of androgen action: recent observations on the domain structure of androgen receptors and the induction of EGF-receptors by androgens in prostate tumor cells.
Journal of steroid biochemistry 1989;32(1B):151-6.
1989: Albert O Brinkmann; P W Faber; H C van Rooij; George G J M Kuiper; C Ris; P Klaassen; Hetty van der Korput; M M Voorhorst; J H van Laar; E Mulder
The human androgen receptor: domain structure, genomic organization and regulation of expression.
Journal of steroid biochemistry 1989;34(1-6):307-10.
1988: D van Loon; M M Voorhorst; Albert O Brinkmann; E Mulder
Purification of the intact monomeric 110 kDa form of the androgen receptor from calf uterus to near homogeneity.
Biochimica et biophysica acta 1988;970(3):278-86.
1988: Jan Trapman; P Klaassen; George G J M Kuiper; Hetty van der Korput; P W Faber; H C van Rooij; A Geurts van Kessel; M M Voorhorst; E Mulder; Albert O Brinkmann
Cloning, structure and expression of a cDNA encoding the human androgen receptor.
Biochemical and biophysical research communications 1988;153(1):241-8.
1988: Gert J van Steenbrugge; J Bolt-de Vries; M A Blankenstein; Albert O Brinkmann; Fritz H Schröder
Transplantable human prostatic carcinoma (PC-82) in athymic nude mice. II. Tumor growth and androgen receptors.
The Prostate 1988;12(2):145-56.
1988: Albert O Brinkmann; George G J M Kuiper; J Bolt-de Vries; E Mulder
In situ photolabelling of the human androgen receptor.
Journal of steroid biochemistry 1988;30(1-6):257-61.
1987: W de Boer; J Bolt; George G J M Kuiper; Albert O Brinkmann; E Mulder
Analysis of steroid- and DNA-binding domains of the calf uterine androgen receptor by limited proteolysis.
Journal of steroid biochemistry 1987;28(1):9-19.
1987: Albert O Brinkmann; J Bolt; Gert J van Steenbrugge; George G J M Kuiper; W de Boer; E Mulder
Characterization of androgen receptors in a transplantable human prostatic adenocarcinoma (PC-82).
The Prostate 1987;10(2):133-43.
1986: W de Boer; J Bolt; Albert O Brinkmann; E Mulder
Differential effects of molybdate on the hydrodynamic and DNA-binding properties of the non-activated and activated forms of the androgen receptor in calf uterus.
Biochimica et biophysica acta 1986;889(2):240-50.
1986: Albert O Brinkmann; George G J M Kuiper; W de Boer; E Mulder; J Bolt; Gert J van Steenbrugge; H J van der Molen
Characterization of androgen receptors after photoaffinity labelling with [3H]methyltrienolone (R1881).
Journal of steroid biochemistry 1986;24(1):245-9.
1985: Albert O Brinkmann; George G J M Kuiper; W de Boer; E Mulder; H J van der Molen
Photoaffinity labelling of androgen receptors with 17 beta-hydroxy-17 alpha-[3H]methyl-4,9,11-estratrien-3-one.
Biochemical and biophysical research communications 1985;126(1):163-9.
1985: Albert O Brinkmann; J Bolt-de Vries; W De Boer; L M Lindh; E Mulder; H J van der Molen
Characterization of steroid hormone receptors with ion-exchange fast protein liquid chromatography.
Journal of steroid biochemistry 1985;22(1):85-90.
1983: Albert O Brinkmann; L M Lindh; D I Breedveld; E Mulder; H J Van Der Molen
Cyproterone acetate prevents translocation of the androgen receptor in the rat prostate.
Molecular and cellular endocrinology 1983;32(2-3):117-29.