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Ulrich Brinkmann

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Chemicals & Drugs

Genes & Molecular Sequences

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Katrin Bühler; Mike Ufer; Alexis Müller-Marbach; Ulrich Brinkmann; Michael Laule; Verena Stangl; Ivar Roots; Karl Stangl; Ingolf Cascorbi
Risk of coronary artery disease as influenced by variants of the human endothelin and endothelin-converting enzyme genes.
Konstanze Diefenbach; Farhad Arjomand Nahad; Christian Meisel; Ingo Fietze; Ingolf Cascorbi; Karl Stangl; Olfert Landt; Reinhold Kerb; Ulrich Brinkmann; Ivar Roots
Identification of twelve polymorphisms in the endothelin-1 gene by use of fluorescently labeled oligonucleotides and PCR with restriction fragment polymorphism analysis.
Peter Dazert; Konrad Meissner; Silke Vogelgesang; Björn Heydrich; Lothar Eckel; Michael Böhm; Rolf Warzok; Reinhold Kerb; Ulrich Brinkmann; Elke Schaeffeler; Matthias Schwab; Ingolf Cascorbi; Gabriele Jedlitschky; Heyo K Kroemer
Expression and localization of the multidrug resistance protein 5 (MRP5/ABCC5), a cellular export pump for cyclic nucleotides, in human heart.

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All Publications

2007: Katrin Bühler; Mike Ufer; Alexis Müller-Marbach; Ulrich Brinkmann; Michael Laule; Verena Stangl; Ivar Roots; Karl Stangl; Ingolf Cascorbi
Risk of coronary artery disease as influenced by variants of the human endothelin and endothelin-converting enzyme genes.
Pharmacogenetics and genomics 2007;17(1):77-83.
2004: Konstanze Diefenbach; Farhad Arjomand Nahad; Christian Meisel; Ingo Fietze; Ingolf Cascorbi; Karl Stangl; Olfert Landt; Reinhold Kerb; Ulrich Brinkmann; Ivar Roots
Identification of twelve polymorphisms in the endothelin-1 gene by use of fluorescently labeled oligonucleotides and PCR with restriction fragment polymorphism analysis.
Clinical chemistry 2004;50(2):448-51.
2003: Peter Dazert; Konrad Meissner; Silke Vogelgesang; Björn Heydrich; Lothar Eckel; Michael Böhm; Rolf Warzok; Reinhold Kerb; Ulrich Brinkmann; Elke Schaeffeler; Matthias Schwab; Ingolf Cascorbi; Gabriele Jedlitschky; Heyo K Kroemer
Expression and localization of the multidrug resistance protein 5 (MRP5/ABCC5), a cellular export pump for cyclic nucleotides, in human heart.
The American journal of pathology 2003;163(4):1567-77.
2003: Céline Verstuyft; Sandrine Morin; J Yang; Marie-Anne Loriot; Véronique Barbu; Reinhold Kerb; Ulrich Brinkmann; Philippe Beaune; Patrice Jaillon; Laurent Becquemont
[A new, rapid and robust genotyping method for CYP2C9 and MDR1].
Annales de biologie clinique 2003;61(3):305-9.
2003: Asra Siddiqui; Reinhold Kerb; Michael E Weale; Ulrich Brinkmann; Alice Smith; David B Goldstein; Nicholas W Wood; Sanjay M Sisodiya
Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1.
The New England journal of medicine 2003;348(15):1442-8.
2003: Céline Verstuyft; Mathias Schwab; Elke Schaeffeler; Reinhold Kerb; Ulrich Brinkmann; Patrice Jaillon; Christian Funck-Brentano; Laurent Becquemont
Digoxin pharmacokinetics and MDR1 genetic polymorphisms.
European journal of clinical pharmacology 2003;58(12):809-12.
2003: Céline Verstuyft; Soraya Strabach; Hakima El-Morabet; Reinhold Kerb; Ulrich Brinkmann; Liliane Dubert; Patrice Jaillon; Christian Funck-Brentano; Germain Trugnan; Laurent Becquemont
Dipyridamole enhances digoxin bioavailability via P-glycoprotein inhibition.
Clinical pharmacology and therapeutics 2003;73(1):51-60.
2003: Matthias Schwab; Elke Schaeffeler; Claudia Marx; Martin F Fromm; Bernd A Kaskas; Joerg Metzler; Eduard F Stange; Hans Herfarth; Juergen Schoelmerich; Michael Gregor; Siegfried Walker; Ingolf Cascorbi; Ivar Roots; Ulrich Brinkmann; Uli Zanger; Michel Eichelbaum
Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis.
Gastroenterology 2003;124(1):26-33.
2003: Peter Behrens; Ulrich Brinkmann; Axel Wellmann
CSE1L/CAS: its role in proliferation and apoptosis.
Apoptosis : an international journal on programmed cell death 2003;8(1):39-44.
2002: Reinhold Kerb; Ulrich Brinkmann; Natalia Chatskaia; Dmitry Gorbunov; Valentin Gorboulev; Esther Mornhinweg; Andrea Keil; Michel Eichelbaum; Hermann Koepsell
Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences.
Pharmacogenetics 2002;12(8):591-5.
2002: Andreas Johne; Karla Köpke; Thomas Gerloff; Ingrid Mai; Stephan Rietbrock; Christian Meisel; Sven Hoffmeyer; Reinhold Kerb; Martin F Fromm; Ulrich Brinkmann; Michel Eichelbaum; Jürgen Brockmöller; Ingolf Cascorbi; Ivar Roots
Modulation of steady-state kinetics of digoxin by haplotypes of the P-glycoprotein MDR1 gene.
Clinical pharmacology and therapeutics 2002;72(5):584-94.
2002: Michael Siegsmund; Ulrich Brinkmann; Elke Scháffeler; Gregor Weirich; Matthias Schwab; Michel Eichelbaum; Peter Fritz; Oliver Burk; Jochen Decker; Peter Alken; Uwe Rothenpieler; Reinhold Kerb; Sven Hoffmeyer; Hiltrud Brauch
Association of the P-glycoprotein transporter MDR1(C3435T) polymorphism with the susceptibility to renal epithelial tumors.
Journal of the American Society of Nephrology : JASN 2002;13(7):1847-54.
2002: Siegfried Drescher; Elke Schaeffeler; Monika Hitzl; ute hofmann; Matthias Schwab; Ulrich Brinkmann; Michel Eichelbaum; Martin F Fromm
MDR1 gene polymorphisms and disposition of the P-glycoprotein substrate fexofenadine.
British journal of clinical pharmacology 2002;53(5):526-34.
2002: Reinhold Kerb; Jürgen Brockmoller; Robert Schlagenhaufer; Raimund Sprenger; Ivar Roots; Ulrich Brinkmann
Influence of GSTT1 and GSTM1 genotypes on sunburn sensitivity.
American journal of pharmacogenomics : genomics-related research in drug development and clinical practice 2002;2(2):147-54.
2002: Ulrich Brinkmann
Functional polymorphisms of the human multidrug resistance (MDR1) gene: correlation with P glycoprotein expression and activity in vivo.
Novartis Foundation symposium 2002;243():207-10; discussion 210-2, 231-5.
2001: Laurent Becquemont; Céline Verstuyft; Reinhold Kerb; Ulrich Brinkmann; M Lebot; Patrice Jaillon; Christian Funck-Brentano
Effect of grapefruit juice on digoxin pharmacokinetics in humans.
Clinical pharmacology and therapeutics 2001;70(4):311-6.
2001: Tapan K Bera; J Bera; Ulrich Brinkmann; Lino Tessarollo; Ira Pastan
Cse1l is essential for early embryonic growth and development.
Molecular and cellular biology 2001;21(20):7020-4.
2001: Elke Schaeffeler; M Eichelbaum; Ulrich Brinkmann; A Penger; S Asante-Poku; Uli Zanger; M Schwab
Frequency of C3435T polymorphism of MDR1 gene in African people.
Lancet 2001;358(9279):383-4.
2001: Reinhold Kerb; Ulrich Brinkmann
Cambridge Healthtech Institute's 2nd Annual Conference on Pharmacogenomics Europe: presaging profits.
Pharmacogenomics 2001;2(3):303-5.
2001: Ulrich Brinkmann; A Keppler-Hafkemeyer; P Hafkemeyer
Recombinant immunotoxins for cancer therapy.
Expert opinion on biological therapy 2001;1(4):693-702.
2001: Peter Behrens; Ulrich Brinkmann; Franz Fogt; Nicolas Wernert; Axel Wellmann
Implication of the proliferation and apoptosis associated CSE1L/CAS gene for breast cancer development.
Anticancer research 2001;21(4A):2413-7.
2001: Axel Wellmann; P Flemming; Peter Behrens; K Wuppermann; H Lang; K Oldhafer; Ira Pastan; Ulrich Brinkmann
High expression of the proliferation and apoptosis associated CSE1L/CAS gene in hepatitis and liver neoplasms: correlation with tumor progression.
International journal of molecular medicine 2001;7(5):489-94.
2001: K Gellner; R Eiselt; Elisabeth Hustert; H Arnold; Ina Koch; Michael Haberl; CJ Deglmann; Oliver Burk; D Buntefuss; S Escher; Jack alvarez; HG Koebe; Ulrich Brinkmann; H P Klenk; K Kleine; Urs A Meyer; Leszek Wojnowski
Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene.
Pharmacogenetics 2001;11(2):111-21.
2001: Ingolf Cascorbi; Thomas Gerloff; Andreas Johne; Christian Meisel; Sven Hoffmeyer; M Schwab; Elke Schaeffeler; Michel Eichelbaum; Ulrich Brinkmann; Ivar Roots
Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects.
Clinical pharmacology and therapeutics 2001;69(3):169-74.
2001: Reinhold Kerb; Sven Hoffmeyer; Ulrich Brinkmann
ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2.
Pharmacogenomics 2001;2(1):51-64.
2001: Ulrich Brinkmann; Michel Eichelbaum
Polymorphisms in the ABC drug transporter gene MDR1.
The pharmacogenomics journal 2001;1(1):59-64.
2001: Reinhold Kerb; A Sükrü Aynacioglu; Jürgen Brockmöller; Robert Schlagenhaufer; S Bauer; T Szekeres; Ahmad Hamwi; Monika Fritzer-Szekeres; C Baumgartner; H Z Ongen; P Güzelbey; Ivar Roots; Ulrich Brinkmann
The predictive value of MDR1, CYP2C9, and CYP2C19 polymorphisms for phenytoin plasma levels.
The pharmacogenomics journal 2001;1(3):204-10.
2000: R Sprenger; Robert Schlagenhaufer; Reinhold Kerb; C Bruhn; Jürgen Brockmöller; Ivar Roots; Ulrich Brinkmann
Characterization of the glutathione S-transferase GSTT1 deletion: discrimination of all genotypes by polymerase chain reaction indicates a trimodular genotype-phenotype correlation.
Pharmacogenetics 2000;10(6):557-65.
2000: Sven Hoffmeyer; Oliver Burk; Oliver Von Richter; H P Arnold; Jürgen Brockmöller; Andreas Johne; I Cascorbi; Thomas Gerloff; Ivar Roots; Michel Eichelbaum; Ulrich Brinkmann
Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(7):3473-8.
2000: Ulrich Brinkmann
Recombinant antibody fragments and immunotoxin fusions for cancer therapy.
In vivo (Athens, Greece) 2000;14(1):21-7.
2000: N Yerushalmi; Ulrich Brinkmann; E Brinkmann; LH Pai; Ira Pastan
Attenuating the growth of tumors by intratumoral administration of DNA encoding Pseudomonas exotoxin via cationic liposomes.
Cancer gene therapy 2000;7(1):91-6.
1999: M Essand; George Vasmatzis; Ulrich Brinkmann; Paul H Duray; Byungkook Lee; Ira Pastan
High expression of a specific T-cell receptor gamma transcript in epithelial cells of the prostate.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(16):9287-92.
1999: Ulrich Brinkmann; E Brinkmann; Tapan K Bera; Axel Wellmann; Ira Pastan
Tissue-specific alternative splicing of the CSE1L/CAS (cellular apoptosis susceptibility) gene.
Genomics 1999;58(1):41-9.
1999: P Hafkemeyer; Ulrich Brinkmann; Michael M Gottesman; Ira Pastan
Apoptosis induced by Pseudomonas exotoxin: a sensitive and rapid marker for gene delivery in vivo.
Human gene therapy 1999;10(6):923-34.
1999: Roland Böni; Axel Wellmann; Y G Man; Günther Hofbauer; Ulrich Brinkmann
Expression of the proliferation and apoptosis-associated CAS protein in benign and malignant cutaneous melanocytic lesions.
The American Journal of dermatopathology 1999;21(2):125-8.
1999: Ulrich Brinkmann; George Vasmatzis; Byungkook Lee; Ira Pastan
Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database.
Cancer research 1999;59(7):1445-8.
1998: A Keppler-Hafkemeyer; Ulrich Brinkmann; Ira Pastan
Role of caspases in immunotoxin-induced apoptosis of cancer cells.
Biochemistry 1998;37(48):16934-42.
1998: U Scherf; Petr Kalab; Mary Dasso; Ira Pastan; Ulrich Brinkmann
The hCSE1/CAS protein is phosphorylated by HeLa extracts and MEK-1: MEK-1 phosphorylation may modulate the intracellular localization of CAS.
Biochemical and biophysical research communications 1998;250(3):623-8.
1998: Ulrich Brinkmann; George Vasmatzis; Byungkook Lee; N Yerushalmi; M Essand; Ira Pastan
PAGE-1, an X chromosome-linked GAGE-like gene that is expressed in normal and neoplastic prostate, testis, and uterus.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(18):10757-62.
1998: Tapan K Bera; Masanori Onda; Ulrich Brinkmann; Ira Pastan
A bivalent disulfide-stabilized Fv with improved antigen binding to erbB2.
Journal of molecular biology 1998;281(3):475-83.
1998: Ulrich Brinkmann
CAS, the human homologue of the yeast chromosome-segregation gene CSE1, in proliferation, apoptosis, and cancer.
American journal of human genetics 1998;62(3):509-13.
1998: George Vasmatzis; M Essand; Ulrich Brinkmann; Byungkook Lee; Ira Pastan
Discovery of three genes specifically expressed in human prostate by expressed sequence tag database analysis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(1):300-4.
1997: Vasily Ogryzko; E Brinkmann; Bruce H Howard; Ira Pastan; Ulrich Brinkmann
Antisense inhibition of CAS, the human homologue of the yeast chromosome segregation gene CSE1, interferes with mitosis in HeLa cells.
Biochemistry 1997;36(31):9493-500.
1997: Ulrich Brinkmann; KO Webber; A Di Carlo; Richard Beers; Partha S Chowdhury; K Chang; V Chaudhary; M Gallo; Ira Pastan
Cloning and expression of the recombinant FAb fragment of monoclonal antibody K1 that reacts with mesothelin present on mesotheliomas and ovarian cancers.
International journal of cancer. Journal international du cancer 1997;71(4):638-44.
1997: Ulrich Brinkmann; A Di Carlo; George Vasmatzis; N Kurochkina; Richard Beers; Byungkook Lee; Ira Pastan
Stabilization of a recombinant Fv fragment by base-loop interconnection and V(H)-V(L) permutation.
Journal of molecular biology 1997;268(1):107-17.
1997: Ulrich Brinkmann; E Mansfield; Ira Pastan
Effects of BCL-2 overexpression on the sensitivity of MCF-7 breast cancer cells to ricin, diphtheria and Pseudomonas toxin and immunotoxins.
Apoptosis : an international journal on programmed cell death 1997;2(2):192-8.
1997: Axel Wellmann; Laszlo Krenacs; T Fest; U Scherf; Ira Pastan; Mark Raffeld; Ulrich Brinkmann
Localization of the cell proliferation and apoptosis-associated CAS protein in lymphoid neoplasms.
The American journal of pathology 1997;150(1):25-30.
1996: Yoram Reiter; Ulrich Brinkmann; Byungkook Lee; Ira Pastan
Engineering antibody Fv fragments for cancer detection and therapy: disulfide-stabilized Fv fragments.
Nature biotechnology 1996;14(10):1239-45.
1996: Ulrich Brinkmann
Recombinant immunotoxins: protein engineering for cancer therapy.
Molecular medicine today 1996;2(10):439-46.
1996: U Scherf; I Benhar; KO Webber; Ira Pastan; Ulrich Brinkmann
Cytotoxic and antitumor activity of a recombinant tumor necrosis factor-B1(Fv) fusion protein on LeY antigen-expressing human cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(9):1523-31.
1996: Ulrich Brinkmann; E Brinkmann; M Gallo; U Scherf; Ira Pastan
Role of CAS, a human homologue to the yeast chromosome segregation gene CSE1, in toxin and tumor necrosis factor mediated apoptosis.
Biochemistry 1996;35(21):6891-9.
1996: U Scherf; Ira Pastan; M C Willingham; Ulrich Brinkmann
The human CAS protein which is homologous to the CSE1 yeast chromosome segregation gene product is associated with microtubules and mitotic spindle.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(7):2670-4.
1996: Pankaj Seth; Ulrich Brinkmann; Gretchen N Schwartz; D Katayose; Ronald E Gress; Kenneth H Cowan
Adenovirus-mediated gene transfer to human breast tumor cells: an approach for cancer gene therapy and bone marrow purging.
Cancer research 1996;56(6):1346-51.
1996: Ulrich Brinkmann; M Gallo; Mihael H Polymeropoulos; Ira Pastan
The human CAS (cellular apoptosis susceptibility) gene mapping on chromosome 20q13 is amplified in BT474 breast cancer cells and part of aberrant chromosomes in breast and colon cancer cell lines.
Genome research 1996;6(3):187-94.
1996: Ira Pastan; L H Pai; Ulrich Brinkmann; D FitzGerald
Recombinant immunotoxins.
Breast cancer research and treatment 1996;38(1):3-9.
1995: Yoram Reiter; Ulrich Brinkmann; S H Jung; Ira Pastan; Byungkook Lee
Disulfide stabilization of antibody Fv: computer predictions and experimental evaluation.
Protein engineering 1995;8(12):1323-31.
1995: Ulrich Brinkmann; E Brinkmann; M Gallo; Ira Pastan
Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(22):10427-31.
1995: Ira Pastan; L H Pai; Ulrich Brinkmann; David J FitzGerald
Recombinant toxins: new therapeutic agents for cancer.
Annals of the New York Academy of Sciences 1995;758():345-54.
1995: Ulrich Brinkmann; Partha S Chowdhury; D M Roscoe; Ira Pastan
Phage display of disulfide-stabilized Fv fragments.
Journal of immunological methods 1995;182(1):41-50.
1995: KO Webber; Yoram Reiter; Ulrich Brinkmann; Robert J Kreitman; Ira Pastan
Preparation and characterization of a disulfide-stabilized Fv fragment of the anti-Tac antibody: comparison with its single-chain analog.
Molecular immunology 1995;32(4):249-58.
1995: Yoram Reiter; I Kurucz; Ulrich Brinkmann; S H Jung; Byungkook Lee; David M Segal; Ira Pastan
Construction of a functional disulfide-stabilized TCR Fv indicates that antibody and TCR Fv frameworks are very similar in structure.
Immunity 1995;2(3):281-7.
1995: Ulrich Brinkmann; E Brinkmann; Ira Pastan
Expression cloning of cDNAs that render cancer cells resistant to Pseudomonas and diphtheria toxin and immunotoxins.
Molecular medicine (Cambridge, Mass.) 1995;1(2):206-16.
1994: Yoram Reiter; Ulrich Brinkmann; S H Jung; Byungkook Lee; P G Kasprzyk; CR King; Ira Pastan
Improved binding and antitumor activity of a recombinant anti-erbB2 immunotoxin by disulfide stabilization of the Fv fragment.
The Journal of biological chemistry 1994;269(28):18327-31.
1994: Yoram Reiter; Robert J Kreitman; Ulrich Brinkmann; Ira Pastan
Cytotoxic and antitumor activity of a recombinant immunotoxin composed of disulfide-stabilized anti-Tac Fv fragment and truncated Pseudomonas exotoxin.
International journal of cancer. Journal international du cancer 1994;58(1):142-9.
1994: I Benhar; Ulrich Brinkmann; KO Webber; Ira Pastan
Mutations of two lysine residues in the CDR loops of a recombinant immunotoxin that reduce its sensitivity to chemical derivatization.
Bioconjugate chemistry 1994;5(4):321-6.
1994: Ulrich Brinkmann; Ira Pastan
Immunotoxins against cancer.
Biochimica et biophysica acta 1994;1198(1):27-45.
1994: Yoram Reiter; L H Pai; Ulrich Brinkmann; Qing-Cheng Wang; Ira Pastan
Antitumor activity and pharmacokinetics in mice of a recombinant immunotoxin containing a disulfide-stabilized Fv fragment.
Cancer research 1994;54(10):2714-8.
1994: Yoram Reiter; Ulrich Brinkmann; Robert J Kreitman; S H Jung; Byungkook Lee; Ira Pastan
Stabilization of the Fv fragments in recombinant immunotoxins by disulfide bonds engineered into conserved framework regions.
Biochemistry 1994;33(18):5451-9.
1994: Yoram Reiter; Ulrich Brinkmann; KO Webber; S H Jung; Byungkook Lee; Ira Pastan
Engineering interchain disulfide bonds into conserved framework regions of Fv fragments: improved biochemical characteristics of recombinant immunotoxins containing disulfide-stabilized Fv.
Protein engineering 1994;7(5):697-704.
1993: Ulrich Brinkmann; Yoram Reiter; S H Jung; Byungkook Lee; Ira Pastan
A recombinant immunotoxin containing a disulfide-stabilized Fv fragment.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(16):7538-42.
1993: Ulrich Brinkmann; B K Lee; Ira Pastan
Recombinant immunotoxins containing the VH or VL domain of monoclonal antibody B3 fused to Pseudomonas exotoxin.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(7):2774-82.
1993: Ulrich Brinkmann; M Gallo; E Brinkmann; S Kunwar; Ira Pastan
A recombinant immunotoxin that is active on prostate cancer cells and that is composed of the Fv region of monoclonal antibody PR1 and a truncated form of Pseudomonas exotoxin.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(2):547-51.
1992: J Buchner; Ira Pastan; Ulrich Brinkmann
A method for increasing the yield of properly folded recombinant fusion proteins: single-chain immunotoxins from renaturation of bacterial inclusion bodies.
Analytical biochemistry 1992;205(2):263-70.
1992: J Buchner; Ulrich Brinkmann; Ira Pastan
Renaturation of a single-chain immunotoxin facilitated by chaperones and protein disulfide isomerase.
Bio/technology (Nature Publishing Company) 1992;10(6):682-5.
1992: Ulrich Brinkmann; J Buchner; Ira Pastan
Independent domain folding of Pseudomonas exotoxin and single-chain immunotoxins: influence of interdomain connections.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(7):3075-9.
1992: Ulrich Brinkmann; L H Pai; David J FitzGerald; Ira Pastan
Alteration of a protease-sensitive region of Pseudomonas exotoxin prolongs its survival in the circulation of mice.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(7):3065-9.
1991: Ulrich Brinkmann; L H Pai; David J FitzGerald; M Willingham; Ira Pastan
B3(Fv)-PE38KDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in mice.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(19):8616-20.