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Ralph Brinster

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Xin Wu; Shaun M Goodyear; John W Tobias; Lara K Abramowitz; Mary R Avarbock; Marisa S Bartolomei; Ralph L Brinster
Fertile offspring derived from mouse spermatogonial stem cells cryopreserved for more than 14 years.
Jon M Oatley; Ralph L Brinster
The germline stem cell niche unit in mammalian testes.
Xin Wu; Mary R Avarbock; Shaun M Goodyear; John W Tobias; Ralph L Brinster
Spermatogonial stem cell self-renewal requires ETV5-mediated downstream activation of Brachyury in mice.

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2012: Xin Wu; Shaun M Goodyear; John W Tobias; Lara K Abramowitz; Mary R Avarbock; Marisa S Bartolomei; Ralph L Brinster
Fertile offspring derived from mouse spermatogonial stem cells cryopreserved for more than 14 years.
Human reproduction (Oxford, England) 2012;27(5):1249-59.
2012: Jon M Oatley; Ralph L Brinster
The germline stem cell niche unit in mammalian testes.
Physiological reviews 2012;92(2):577-95.
2011: Xin Wu; Mary R Avarbock; Shaun M Goodyear; John W Tobias; Ralph L Brinster
Spermatogonial stem cell self-renewal requires ETV5-mediated downstream activation of Brachyury in mice.
Biology of reproduction 2011;85(6):1114-23.
2011: Zhiyv Niu; Shilpa Rao; John W Tobias; Xin Wu; Mary R Avarbock; Shaun M Goodyear; Ralph L Brinster
MicroRNA-21 regulates the self-renewal of mouse spermatogonial stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(31):12740-5.
2011: Jonathan A Schmidt; Lara K Abramowitz; Hiroshi Kubota; Xin Wu; Zhiyv Niu; Mary R Avarbock; John W Tobias; Marisa S Bartolomei; Ralph L Brinster
In vivo and in vitro aging is detrimental to mouse spermatogonial stem cell function.
Biology of reproduction 2011;84(4):698-706.
2010: Jon M Oatley; Amy V Kaucher; Mary R Avarbock; Ralph L Brinster
Regulation of mouse spermatogonial stem cell differentiation by STAT3 signaling.
Biology of reproduction 2010;83(3):427-33.
2010: Xin Wu; Jon M Oatley; Melissa J Oatley; Amy V Kaucher; Mary R Avarbock; Ralph L Brinster
The POU domain transcription factor POU3F1 is an important intrinsic regulator of GDNF-induced survival and self-renewal of mouse spermatogonial stem cells.
Biology of reproduction 2010;82(6):1103-11.
2009: Xin Wu; Jonathan A Schmidt; Mary R Avarbock; John W Tobias; Claire A Carlson; Thomas F Kolon; Jill P Ginsberg; Ralph L Brinster
Prepubertal human spermatogonia and mouse gonocytes share conserved gene expression of germline stem cell regulatory molecules.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(51):21672-7.
2009: Hiroshi Kubota; Mary R Avarbock; Jonathan A Schmidt; Ralph L Brinster
Spermatogonial stem cells derived from infertile Wv/Wv mice self-renew in vitro and generate progeny following transplantation.
Biology of reproduction 2009;81(2):293-301.
2009: Jonathan A Schmidt; Mary R Avarbock; John W Tobias; Ralph L Brinster
Identification of glial cell line-derived neurotrophic factor-regulated genes important for spermatogonial stem cell self-renewal in the rat.
Biology of reproduction 2009;81(1):56-66.
2009: Jonathan A Schmidt; Jon M Oatley; Ralph L Brinster
Female mice delay reproductive aging in males.
Biology of reproduction 2009;80(5):1009-14.
2009: Jon M Oatley; Melissa J Oatley; Mary R Avarbock; John W Tobias; Ralph L Brinster
Colony stimulating factor 1 is an extrinsic stimulator of mouse spermatogonial stem cell self-renewal.
Development (Cambridge, England) 2009;136(7):1191-9.
2008: Kyle E Orwig; Buom-Yong Ryu; Stephen R Master; Bart T Phillips; Matthias Mack; Mary R Avarbock; Lewis A Chodosh; Ralph L Brinster
Genes involved in post-transcriptional regulation are overrepresented in stem/progenitor spermatogonia of cryptorchid mouse testes.
Stem cells (Dayton, Ohio) 2008;26(4):927-38.
2008: Jon M Oatley; Ralph L Brinster
Regulation of spermatogonial stem cell self-renewal in mammals.
Annual review of cell and developmental biology 2008;24():263-86.
2008: Hiroshi Kubota; Ralph L Brinster
Culture of rodent spermatogonial stem cells, male germline stem cells of the postnatal animal.
Methods in cell biology 2008;86():59-84.
2007: Jon M Oatley; Mary R Avarbock; Ralph L Brinster
Glial cell line-derived neurotrophic factor regulation of genes essential for self-renewal of mouse spermatogonial stem cells is dependent on Src family kinase signaling.
The Journal of biological chemistry 2007;282(35):25842-51.
2007: Ralph L Brinster
Male germline stem cells: from mice to men.
Science (New York, N.Y.) 2007;316(5823):404-5.
2007: Buom-Yong Ryu; Kyle E Orwig; Jon M Oatley; Chih-Cheng Lin; Lung-Ji Chang; Mary R Avarbock; Ralph L Brinster
Efficient generation of transgenic rats through the male germline using lentiviral transduction and transplantation of spermatogonial stem cells.
Journal of andrology 2007;28(2):353-60.
2006: Jon M Oatley; Mary R Avarbock; Aino I Telaranta; Douglas T Fearon; Ralph L Brinster
Identifying genes important for spermatogonial stem cell self-renewal and survival.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(25):9524-9.
2006: Buom-Yong Ryu; Kyle E Orwig; Jon M Oatley; Mary R Avarbock; Ralph L Brinster
Effects of aging and niche microenvironment on spermatogonial stem cell self-renewal.
Stem cells (Dayton, Ohio) 2006;24(6):1505-11.
2006: Hiroshi Kubota; Ralph L Brinster
Technology insight: In vitro culture of spermatogonial stem cells and their potential therapeutic uses.
Nature clinical practice. Endocrinology & metabolism 2006;2(2):99-108.
2006: Jon M Oatley; Ralph L Brinster
Spermatogonial stem cells.
Methods in enzymology 2006;419():259-82.
2005: Buom-Yong Ryu; Hiroshi Kubota; Mary R Avarbock; Ralph L Brinster
Conservation of spermatogonial stem cell self-renewal signaling between mouse and rat.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(40):14302-7.
2004: Hiroshi Kubota; Mary R Avarbock; Ralph L Brinster
Growth factors essential for self-renewal and expansion of mouse spermatogonial stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(47):16489-94.
2004: Buom-Yong Ryu; Kyle E Orwig; Hiroshi Kubota; Mary R Avarbock; Ralph L Brinster
Phenotypic and functional characteristics of spermatogonial stem cells in rats.
Developmental biology 2004;274(1):158-70.
2004: Hiroshi Kubota; Mary R Avarbock; Ralph L Brinster
Culture conditions and single growth factors affect fate determination of mouse spermatogonial stem cells.
Biology of reproduction 2004;71(3):722-31.
2003: Buom-Yong Ryu; Kyle E Orwig; Mary R Avarbock; Ralph L Brinster
Stem cell and niche development in the postnatal rat testis.
Developmental biology 2003;263(2):253-63.
2003: Clayton J Brinster; Buom-Yong Ryu; Mary R Avarbock; Levent Karagenc; Ralph L Brinster; Kyle E Orwig
Restoration of fertility by germ cell transplantation requires effective recipient preparation.
Biology of reproduction 2003;69(2):412-20.
2003: Makoto Nagano; Buom-Yong Ryu; Clayton J Brinster; Mary R Avarbock; Ralph L Brinster
Maintenance of mouse male germ line stem cells in vitro.
Biology of reproduction 2003;68(6):2207-14.
2003: Hiroshi Kubota; Mary R Avarbock; Ralph L Brinster
Spermatogonial stem cells share some, but not all, phenotypic and functional characteristics with other stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(11):6487-92.
2003: Takashi Shinohara; Kyle E Orwig; Mary R Avarbock; Ralph L Brinster
Restoration of spermatogenesis in infertile mice by Sertoli cell transplantation.
Biology of reproduction 2003;68(3):1064-71.
2002: Makoto Nagano; Pasquale Patrizio; Ralph L Brinster
Long-term survival of human spermatogonial stem cells in mouse testes.
Fertility and sterility 2002;78(6):1225-33.
2002: Kyle E Orwig; Buom-Yong Ryu; Mary R Avarbock; Ralph L Brinster
Male germ-line stem cell potential is predicted by morphology of cells in neonatal rat testes.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(18):11706-11.
2002: Kyle E Orwig; Mary R Avarbock; Ralph L Brinster
Retrovirus-mediated modification of male germline stem cells in rats.
Biology of reproduction 2002;67(3):874-9.
2002: Makoto Nagano; Deborah J Watson; Buom-Yong Ryu; John H Wolfe; Ralph L Brinster
Lentiviral vector transduction of male germ line stem cells in mice.
FEBS letters 2002;524(1-3):111-5.
2002: Ralph L Brinster
Germline stem cell transplantation and transgenesis.
Science (New York, N.Y.) 2002;296(5576):2174-6.
2002: Takashi Shinohara; Kyle E Orwig; Mary R Avarbock; Ralph L Brinster
Germ line stem cell competition in postnatal mouse testes.
Biology of reproduction 2002;66(5):1491-7.
2002: Kyle E Orwig; Takashi Shinohara; Mary R Avarbock; Ralph L Brinster
Functional analysis of stem cells in the adult rat testis.
Biology of reproduction 2002;66(4):944-9.
2001: Makoto Nagano; Clayton J Brinster; Kyle E Orwig; Buom-Yong Ryu; Mary R Avarbock; Ralph L Brinster
Transgenic mice produced by retroviral transduction of male germ-line stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(23):13090-5.
2001: Takashi Shinohara; Kyle E Orwig; Mary R Avarbock; Ralph L Brinster
Remodeling of the postnatal mouse testis is accompanied by dramatic changes in stem cell number and niche accessibility.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(11):6186-91.
2001: Makoto Nagano; John R McCarrey; Ralph L Brinster
Primate spermatogonial stem cells colonize mouse testes.
Biology of reproduction 2001;64(5):1409-16.
2001: Ina Dobrinski; T Ogawa; Mary R Avarbock; Ralph L Brinster
Effect of the GnRH-agonist leuprolide on colonization of recipient testes by donor spermatogonial stem cells after transplantation in mice.
Tissue & cell 2001;33(2):200-7.
2000: Ina Dobrinski; Mary R Avarbock; Ralph L Brinster
Germ cell transplantation from large domestic animals into mouse testes.
Molecular reproduction and development 2000;57(3):270-9.
2000: Takashi Shinohara; Kyle E Orwig; Mary R Avarbock; Ralph L Brinster
Spermatogonial stem cell enrichment by multiparameter selection of mouse testis cells.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(15):8346-51.
2000: Makoto Nagano; T Shinohara; Mary R Avarbock; Ralph L Brinster
Retrovirus-mediated gene delivery into male germ line stem cells.
FEBS letters 2000;475(1):7-10.
2000: Takashi Shinohara; Mary R Avarbock; Ralph L Brinster
Functional analysis of spermatogonial stem cells in Steel and cryptorchid infertile mouse models.
Developmental biology 2000;220(2):401-11.
2000: Takashi Shinohara; Ralph L Brinster
Enrichment and transplantation of spermatogonial stem cells.
International journal of andrology 2000;23 Suppl 2():89-91.
2000: T Ogawa; Ina Dobrinski; Mary R Avarbock; Ralph L Brinster
Transplantation of male germ line stem cells restores fertility in infertile mice.
Nature medicine 2000;6(1):29-34.
1999: Ina Dobrinski; Mary R Avarbock; Ralph L Brinster
Transplantation of germ cells from rabbits and dogs into mouse testes.
Biology of reproduction 1999;61(5):1331-9.
1999: T Ogawa; Ina Dobrinski; Ralph L Brinster
Recipient preparation is critical for spermatogonial transplantation in the rat.
Tissue & cell 1999;31(5):461-72.
1999: Gleydes G Parreira; T Ogawa; Mary R Avarbock; Luiz R França; C L Hausler; Ralph L Brinster; Lonnie D Russell
Development of germ cell transplants: morphometric and ultrastructural studies.
Tissue & cell 1999;31(3):242-54.
1999: Ina Dobrinski; T Ogawa; Mary R Avarbock; Ralph L Brinster
Computer assisted image analysis to assess colonization of recipient seminiferous tubules by spermatogonial stem cells from transgenic donor mice.
Molecular reproduction and development 1999;53(2):142-8.
1999: Makoto Nagano; Mary R Avarbock; Ralph L Brinster
Pattern and kinetics of mouse donor spermatogonial stem cell colonization in recipient testes.
Biology of reproduction 1999;60(6):1429-36.
1999: Takashi Shinohara; Mary R Avarbock; Ralph L Brinster
beta1- and alpha6-integrin are surface markers on mouse spermatogonial stem cells.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(10):5504-9.
1999: T Ogawa; Ina Dobrinski; Mary R Avarbock; Ralph L Brinster
Xenogeneic spermatogenesis following transplantation of hamster germ cells to mouse testes.
Biology of reproduction 1999;60(2):515-21.
1998: Luiz R França; T Ogawa; Mary R Avarbock; Ralph L Brinster; Lonnie D Russell
Germ cell genotype controls cell cycle during spermatogenesis in the rat.
Biology of reproduction 1998;59(6):1371-7.
1998: Gleydes G Parreira; T Ogawa; Mary R Avarbock; Luiz R França; Ralph L Brinster; Lonnie D Russell
Development of germ cell transplants in mice.
Biology of reproduction 1998;59(6):1360-70.
1998: T Ogawa; Ina Dobrinski; Mary R Avarbock; Ralph L Brinster
Leuprolide, a gonadotropin-releasing hormone agonist, enhances colonization after spermatogonial transplantation into mouse testes.
Tissue & cell 1998;30(5):583-8.
1998: Ralph L Brinster; Makoto Nagano
Spermatogonial stem cell transplantation, cryopreservation and culture.
Seminars in cell & developmental biology 1998;9(4):401-9.
1998: Makoto Nagano; Mary R Avarbock; E B Leonida; Clayton J Brinster; Ralph L Brinster
Culture of mouse spermatogonial stem cells.
Tissue & cell 1998;30(4):389-97.
1998: Makoto Nagano; Ralph L Brinster
Spermatogonial transplantation and reconstitution of donor cell spermatogenesis in recipient mice.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1998;106(1):47-55; discussion 56-7.
1997: T Ogawa; J M Aréchaga; Mary R Avarbock; Ralph L Brinster
Transplantation of testis germinal cells into mouse seminiferous tubules.
The International journal of developmental biology 1997;41(1):111-22.
1996: Lonnie D Russell; Ralph L Brinster
Ultrastructural observations of spermatogenesis following transplantation of rat testis cells into mouse seminiferous tubules.
Journal of andrology 1996;17(6):615-27.
1996: Lonnie D Russell; Luiz R França; Ralph L Brinster
Ultrastructural observations of spermatogenesis in mice resulting from transplantation of mouse spermatogonia.
Journal of andrology 1996;17(6):603-14.
1996: Mary R Avarbock; C J Brinster; Ralph L Brinster
Reconstitution of spermatogenesis from frozen spermatogonial stem cells.
Nature medicine 1996;2(6):693-6.
1996: D E Clouthier; Mary R Avarbock; S D Maika; Robert E Hammer; Ralph L Brinster
Rat spermatogenesis in mouse testis.
Nature 1996;381(6581):418-21.
1995: E P Sandgren; J A Schroeder; T H Qui; Richard D Palmiter; Ralph L Brinster; David C Lee
Inhibition of mammary gland involution is associated with transforming growth factor alpha but not c-myc-induced tumorigenesis in transgenic mice.
Cancer research 1995;55(17):3915-27.
1995: JC Erickson; B A Masters; Edward J Kelly; Ralph L Brinster; Richard D Palmiter
Expression of human metallothionein-III in transgenic mice.
Neurochemistry international 1995;27(1):35-41.
1995: J A Rhim; E P Sandgren; Richard D Palmiter; Ralph L Brinster
Complete reconstitution of mouse liver with xenogeneic hepatocytes.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(11):4942-6.
1995: J A Rhim; W Connor; G H Dixon; C J Harendza; D P Evenson; Richard D Palmiter; Ralph L Brinster
Expression of an avian protamine in transgenic mice disrupts chromatin structure in spermatozoa.
Biology of reproduction 1995;52(1):20-32.
1994: Ralph L Brinster; Mary R Avarbock
Germline transmission of donor haplotype following spermatogonial transplantation.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(24):11303-7.
1994: Ralph L Brinster; J W Zimmermann
Spermatogenesis following male germ-cell transplantation.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(24):11298-302.
1994: C J Quaife; Gary Hoyle; G J Froelick; S D Findley; E E Baetge; R R Behringer; J P Hammang; Ralph L Brinster; Richard D Palmiter
Visualization and ablation of phenylethanolamine N-methyltransferase producing cells in transgenic mice.
Transgenic research 1994;3(6):388-400.
1994: B A Masters; C J Quaife; JC Erickson; Edward J Kelly; G J Froelick; B P Zambrowicz; Ralph L Brinster; Richard D Palmiter
Metallothionein III is expressed in neurons that sequester zinc in synaptic vesicles.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1994;14(10):5844-57.
1994: B A Bamber; B A Masters; Gary Hoyle; Ralph L Brinster; Richard D Palmiter
Leukemia inhibitory factor induces neurotransmitter switching in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(17):7839-43.
1994: B P Zambrowicz; J W Zimmermann; C J Harendza; E M Simpson; David C Page; Ralph L Brinster; Richard D Palmiter
Expression of a mouse Zfy-1/lacZ transgene in the somatic cells of the embryonic gonad and germ cells of the adult testis.
Development (Cambridge, England) 1994;120(6):1549-59.
1994: Gary Hoyle; E H Mercer; Richard D Palmiter; Ralph L Brinster
Cell-specific expression from the human dopamine beta-hydroxylase promoter in transgenic mice is controlled via a combination of positive and negative regulatory elements.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1994;14(5 Pt 1):2455-63.
1994: J A Rhim; E P Sandgren; Jay L Degen; Richard D Palmiter; Ralph L Brinster
Replacement of diseased mouse liver by hepatic cell transplantation.
Science (New York, N.Y.) 1994;263(5150):1149-52.
1994: B A Masters; Edward J Kelly; C J Quaife; Ralph L Brinster; Richard D Palmiter
Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(2):584-8.
1993: M Theisen; R R Behringer; G G Cadd; Ralph L Brinster; G Stanley McKnight
A C/EBP-binding site in the transferrin promoter is essential for expression in the liver but not the brain of transgenic mice.
Molecular and cellular biology 1993;13(12):7666-76.
1993: Richard D Palmiter; E P Sandgren; David M Koeller; Ralph L Brinster
Distal regulatory elements from the mouse metallothionein locus stimulate gene expression in transgenic mice.
Molecular and cellular biology 1993;13(9):5266-75.
1993: B P Zambrowicz; C J Harendza; J W Zimmermann; Ralph L Brinster; Richard D Palmiter
Analysis of the mouse protamine 1 promoter in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):5071-5.
1993: Gary Hoyle; E H Mercer; Richard D Palmiter; Ralph L Brinster
Expression of NGF in sympathetic neurons leads to excessive axon outgrowth from ganglia but decreased terminal innervation within tissues.
Neuron 1993;10(6):1019-34.
1993: Ralph L Brinster
Stem cells and transgenic mice in the study of development.
The International journal of developmental biology 1993;37(1):89-99.
1993: N C Luetteke; David C Lee; Richard D Palmiter; Ralph L Brinster; E P Sandgren
Regulation of fat and muscle development by transforming growth factor alpha in transgenic mice and in cultured cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993;4(3):203-13.
1993: R R Behringer; Crotty David; V M Tennyson; Ralph L Brinster; Richard D Palmiter; Debra J Wolgemuth
Sequences 5' of the homeobox of the Hox-1.4 gene direct tissue-specific expression of lacZ during mouse development.
Development (Cambridge, England) 1993;117(3):823-33.
1993: E P Sandgren; N C Luetteke; T H Qiu; Richard D Palmiter; Ralph L Brinster; David C Lee
Transforming growth factor alpha dramatically enhances oncogene-induced carcinogenesis in transgenic mouse pancreas and liver.
Molecular and cellular biology 1993;13(1):320-30.
1992: E P Sandgren; Richard D Palmiter; J L Heckel; Ralph L Brinster; Jay L Degen
DNA rearrangement causes hepatocarcinogenesis in albumin-plasminogen activator transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(23):11523-7.
1992: G G Cadd; Gary Hoyle; C J Quaife; Brett T Marck; Alvin M Matsumoto; Ralph L Brinster; Richard D Palmiter
Alteration of neurotransmitter phenotype in noradrenergic neurons of transgenic mice.
Molecular endocrinology (Baltimore, Md.) 1992;6(11):1951-60.
1992: J J Peschon; R R Behringer; R L Cate; K A Harwood; Rejean L Idzerda; Ralph L Brinster; Richard D Palmiter
Directed expression of an oncogene to Sertoli cells in transgenic mice using mullerian inhibiting substance regulatory sequences.
Molecular endocrinology (Baltimore, Md.) 1992;6(9):1403-11.
1992: Carolyn W Gibson; Edward T Lally; R C Herold; Sylvia Decker; Ralph L Brinster; E P Sandgren
Odontogenic tumors in mice carrying albumin-myc and albumin-rats transgenes.
Calcified tissue international 1992;51(2):162-7.
1991: Raj P Kapur; Gary Hoyle; E H Mercer; Ralph L Brinster; Richard D Palmiter
Some neuronal cell populations express human dopamine beta-hydroxylase-lacZ transgenes transiently during embryonic development.
Neuron 1991;7(5):717-27.
1991: E H Mercer; Gary Hoyle; Raj P Kapur; Ralph L Brinster; Richard D Palmiter
The dopamine beta-hydroxylase gene promoter directs expression of E. coli lacZ to sympathetic and other neurons in adult transgenic mice.
Neuron 1991;7(5):703-16.
1991: E P Sandgren; Richard D Palmiter; J L Heckel; C C Daugherty; Ralph L Brinster; Jay L Degen
Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene.
Cell 1991;66(2):245-56.
1991: D Lo; Vernon Pursel; P J Linton; E Sandgren; R Behringer; C Rexroad; Richard D Palmiter; Ralph L Brinster
Expression of mouse IgA by transgenic mice, pigs and sheep.
European journal of immunology 1991;21(4):1001-6.
1991: J J Caterina; Thomas M Ryan; K M Pawlik; Richard D Palmiter; Ralph L Brinster; R R Behringer; Tim M Townes
Human beta-globin locus control region: analysis of the 5' DNase I hypersensitive site HS 2 in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(5):1626-30.
1991: Richard D Palmiter; E P Sandgren; M R Avarbock; D D Allen; Ralph L Brinster
Heterologous introns can enhance expression of transgenes in mice.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(2):478-82.
1991: E P Sandgren; C J Quaife; A G Paulovich; Richard D Palmiter; Ralph L Brinster
Pancreatic tumor pathogenesis reflects the causative genetic lesion.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(1):93-7.
1990: Lawrence A Frohman; T R Downs; Y Kashio; Ralph L Brinster
Tissue distribution and molecular heterogeneity of human growth hormone-releasing factor in the transgenic mouse.
Endocrinology 1990;127(5):2149-56.
1990: Robert E Braun; D Lo; C A Pinkert; G Widera; R A Flavell; Richard D Palmiter; Ralph L Brinster
Infertility in male transgenic mice: disruption of sperm development by HSV-tk expression in postmeiotic germ cells.
Biology of reproduction 1990;43(4):684-93.
1990: R R Behringer; T M Lewin; C J Quaife; Richard D Palmiter; Ralph L Brinster; Augustine D'ercole
Expression of insulin-like growth factor I stimulates normal somatic growth in growth hormone-deficient transgenic mice.
Endocrinology 1990;127(3):1033-40.
1990: J L Heckel; E P Sandgren; Jay L Degen; Richard D Palmiter; Ralph L Brinster
Neonatal bleeding in transgenic mice expressing urokinase-type plasminogen activator.
Cell 1990;62(3):447-56.
1990: James F Markmann; Clyde F Barker; D Lo; Ralph L Brinster; E Heber-Katz; Ali Naji
Immunologic consequence of class II+ pancreatic islet allografts on recipient responsiveness.
Transplantation proceedings 1990;22(4):2052-3.
1990: E P Sandgren; N C Luetteke; Richard D Palmiter; Ralph L Brinster; David C Lee
Overexpression of TGF alpha in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast.
Cell 1990;61(6):1121-35.
1990: R R Behringer; R L Cate; G J Froelick; Richard D Palmiter; Ralph L Brinster
Abnormal sexual development in transgenic mice chronically expressing müllerian inhibiting substance.
Nature 1990;345(6271):167-70.
1990: James F Markmann; Clyde F Barker; D Lo; Ralph L Brinster; J Tomaszewski; Ali Naji
Islet endocrine cell MHC antigen expression in allograft rejection.
Transplantation proceedings 1990;22(2):847-8.
1990: R R Behringer; Thomas M Ryan; Richard D Palmiter; Ralph L Brinster; Tim M Townes
Human gamma- to beta-globin gene switching in transgenic mice.
Genes & development 1990;4(3):380-9.
1990: Thomas M Ryan; Tim M Townes; Michael Reilly; Toshio Asakura; Richard D Palmiter; Ralph L Brinster; R R Behringer
Human sickle hemoglobin in transgenic mice.
Science (New York, N.Y.) 1990;247(4942):566-8.
1989: D Lo; L C Burkly; R A Flavell; Richard D Palmiter; Ralph L Brinster
Tolerance to class II MHC in transgenic mice.
Seminars in immunology 1989;1(2):147-53.
1989: Rejean L Idzerda; R R Behringer; M Theisen; J I Huggenvik; G Stanley McKnight; Ralph L Brinster
Expression from the transferrin gene promoter in transgenic mice.
Molecular and cellular biology 1989;9(11):5154-62.
1989: R R Behringer; Thomas M Ryan; Michael Reilly; Toshio Asakura; Richard D Palmiter; Ralph L Brinster; Tim M Townes
Synthesis of functional human hemoglobin in transgenic mice.
Science (New York, N.Y.) 1989;245(4921):971-3.
1989: Ralph L Brinster; R E Braun; D Lo; Mary R Avarbock; F Oram; Richard D Palmiter
Targeted correction of a major histocompatibility class II E alpha gene by DNA microinjected into mouse eggs.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(18):7087-91.
1989: A K Brar; Ralph L Brinster; Lawrence A Frohman
Immunohistochemical analysis of human growth hormone-releasing hormone gene expression in transgenic mice.
Endocrinology 1989;125(2):801-9.
1989: D Lo; L C Burkly; R A Flavell; Richard D Palmiter; Ralph L Brinster
Tolerance in transgenic mice expressing class II major histocompatibility complex on pancreatic acinar cells.
The Journal of experimental medicine 1989;170(1):87-104.
1989: Robert E Braun; J J Peschon; R R Behringer; Ralph L Brinster; Richard D Palmiter
Protamine 3'-untranslated sequences regulate temporal translational control and subcellular localization of growth hormone in spermatids of transgenic mice.
Genes & development 1989;3(6):793-802.
1989: E P Sandgren; C J Quaife; C A Pinkert; Richard D Palmiter; Ralph L Brinster
Oncogene-induced liver neoplasia in transgenic mice.
Oncogene 1989;4(6):715-24.
1989: Thomas M Ryan; R R Behringer; N C Martin; Tim M Townes; Richard D Palmiter; Ralph L Brinster
A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice.
Genes & development 1989;3(3):314-23.
1989: Robert E Braun; R R Behringer; J J Peschon; Ralph L Brinster; Richard D Palmiter
Genetically haploid spermatids are phenotypically diploid.
Nature 1989;337(6205):373-6.
1989: Thomas M Ryan; R R Behringer; Tim M Townes; Richard D Palmiter; Ralph L Brinster
High-level erythroid expression of human alpha-globin genes in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(1):37-41.
1989: J J Peschon; R R Behringer; Richard D Palmiter; Ralph L Brinster
Expression of mouse protamine 1 genes in transgenic mice.
Annals of the New York Academy of Sciences 1989;564():186-97.
1989: C J Quaife; L S Mathews; C A Pinkert; Robert E Hammer; Ralph L Brinster; Richard D Palmiter
Histopathology associated with elevated levels of growth hormone and insulin-like growth factor I in transgenic mice.
Endocrinology 1989;124(1):40-8.
1989: Tim M Townes; Thomas M Ryan; R R Behringer; Richard D Palmiter; Ralph L Brinster
DNase I super-hypersensitive sites direct high level erythroid expression of human alpha-, beta- and beta s- globin genes in transgenic mice.
Progress in clinical and biological research 1989;316A():47-61.
1988: L S Mathews; Robert E Hammer; R R Behringer; Augustine D'ercole; G I Bell; Ralph L Brinster; Richard D Palmiter
Growth enhancement of transgenic mice expressing human insulin-like growth factor I.
Endocrinology 1988;123(6):2827-33.
1988: James F Markmann; D Lo; Ali Naji; Richard D Palmiter; Ralph L Brinster; E Heber-Katz
Antigen presenting function of class II MHC expressing pancreatic beta cells.
Nature 1988;336(6198):476-9.
1988: L S Mathews; Robert E Hammer; Ralph L Brinster; Richard D Palmiter
Expression of insulin-like growth factor I in transgenic mice with elevated levels of growth hormone is correlated with growth.
Endocrinology 1988;123(1):433-7.
1988: E E Baetge; R R Behringer; Albee Messing; Ralph L Brinster; Richard D Palmiter
Transgenic mice express the human phenylethanolamine N-methyltransferase gene in adrenal medulla and retina.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(10):3648-52.
1988: D Lo; L C Burkly; G Widera; C Cowing; R A Flavell; Richard D Palmiter; Ralph L Brinster
Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells.
Cell 1988;53(1):159-68.
1988: R R Behringer; L S Mathews; Richard D Palmiter; Ralph L Brinster
Dwarf mice produced by genetic ablation of growth hormone-expressing cells.
Genes & development 1988;2(4):453-61.
1988: R R Behringer; J J Peschon; Albee Messing; C L Gartside; Stephen D Hauschka; Richard D Palmiter; Ralph L Brinster
Heart and bone tumors in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(8):2648-52.
1988: Ralph L Brinster; J M Allen; R R Behringer; R E Gelinas; Richard D Palmiter
Introns increase transcriptional efficiency in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(3):836-40.
1987: G Widera; L C Burkly; C A Pinkert; E C Böttger; C Cowing; Richard D Palmiter; Ralph L Brinster; R A Flavell
Transgenic mice selectively lacking MHC class II (I-E) antigen expression on B cells: an in vivo approach to investigate Ia gene function.
Cell 1987;51(2):175-87.
1987: D M Ornitz; Robert E Hammer; Albee Messing; Richard D Palmiter; Ralph L Brinster
Pancreatic neoplasia induced by SV40 T-antigen expression in acinar cells of transgenic mice.
Science (New York, N.Y.) 1987;238(4824):188-93.
1987: D M Ornitz; Robert E Hammer; B L Davison; Ralph L Brinster; Richard D Palmiter
Promoter and enhancer elements from the rat elastase I gene function independently of each other and of heterologous enhancers.
Molecular and cellular biology 1987;7(10):3466-72.
1987: R R Behringer; Robert E Hammer; Ralph L Brinster; Richard D Palmiter; Tim M Townes
Two 3' sequences direct adult erythroid-specific expression of human beta-globin genes in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(20):7056-60.
1987: Robert E Hammer; Galvin Swift; D M Ornitz; C J Quaife; Richard D Palmiter; Ralph L Brinster; Raymond J MacDonald
The rat elastase I regulatory element is an enhancer that directs correct cell specificity and developmental onset of expression in transgenic mice.
Molecular and cellular biology 1987;7(8):2956-67.
1987: Richard D Palmiter; R R Behringer; C J Quaife; Françoise Maxwell; Ian H Maxwell; Ralph L Brinster
Cell lineage ablation in transgenic mice by cell-specific expression of a toxin gene.
Cell 1987;50(3):435-43.
1987: C A Pinkert; D M Ornitz; Ralph L Brinster; Richard D Palmiter
An albumin enhancer located 10 kb upstream functions along with its promoter to direct efficient, liver-specific expression in transgenic mice.
Genes & development 1987;1(3):268-76.
1987: C J Quaife; C A Pinkert; D M Ornitz; Richard D Palmiter; Ralph L Brinster
Pancreatic neoplasia induced by ras expression in acinar cells of transgenic mice.
Cell 1987;48(6):1023-34.
1987: Raymond J MacDonald; Galvin Swift; Robert E Hammer; D M Ornitz; B P Davis; Ralph L Brinster; Richard D Palmiter
Targeted expression of cloned genes in transgenic mice.
Progress in brain research 1987;71():3-12.
1986: Raymond J MacDonald; Robert E Hammer; Galvin Swift; B P Davis; Ralph L Brinster
Transgenic progeny inherit tissue-specific expression of rat elastase I genes.
DNA (Mary Ann Liebert, Inc.) 1986;5(5):393-401.
1986: Raymond J MacDonald; Robert E Hammer; Galvin Swift; D M Ornitz; B P Davis; Richard D Palmiter; Ralph L Brinster
Tissue-specific expression of pancreatic genes in transgenic mice.
Annals of the New York Academy of Sciences 1986;478():131-46.
1985: C A Pinkert; G Widera; C Cowing; E Heber-Katz; Richard D Palmiter; R A Flavell; Ralph L Brinster
Tissue-specific, inducible and functional expression of the E alpha d MHC class II gene in transgenic mice.
The EMBO journal 1985;4(9):2225-30.
1985: D M Ornitz; Richard D Palmiter; Robert E Hammer; Ralph L Brinster; Galvin Swift; Raymond J MacDonald
Specific expression of an elastase-human growth hormone fusion gene in pancreatic acinar cells of transgenic mice.
Nature 1985;313(6003):600-2.
1985: D M Ornitz; Richard D Palmiter; Albee Messing; Robert E Hammer; C A Pinkert; Ralph L Brinster
Elastase I promoter directs expression of human growth hormone and SV40 T antigen genes to pancreatic acinar cells in transgenic mice.
Cold Spring Harbor symposia on quantitative biology 1985;50():399-409.
1984: Galvin Swift; Robert E Hammer; Raymond J MacDonald; Ralph L Brinster
Tissue-specific expression of the rat pancreatic elastase I gene in transgenic mice.
Cell 1984;38(3):639-46.