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Jean-Pierre Brion

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Kunie Ando; Michèle Authelet; Jean-Pierre Brion; Anaïs Chanut; R Dedecker; Pascale LACOR; Jérémie Lavaur; Marie-Claude Potier; Ekaterina Rogaeva; Véronique Sazdovitch; Virginie Stygelbout; Valérie Suain; Charles Duyckaerts
Clathrin adaptor CALM/PICALM is associated with neurofibrillary tangles and is cleaved in Alzheimer's brains.
Nathalie Pierrot; Bernadette Tasiaux; Donatienne Tyteca; Jean-Pierre Brion; Dominique Campion; Pierre J Courtoy; Ludovic D'auria; Jean-Baptiste Demoulin; Ilse Dewachter; Philippe Gailly; Laetitia El Haylani; Aurélie Hendrickx; Pascal Kienlen-Campard; Annie Laquerrière; Nathalie Muls; Francisca N'Kuli; Jean-Noël Octave
Amyloid precursor protein controls cholesterol turnover needed for neuronal activity.
Charles Nicaise; Roland Pochet; Rajarshi Putatunda; Kathleen A Regan; Megan C Wright; Jean-Pierre Brion; David M Frank; Tamara J Hala; Karelle Leroy; Angelo C Lepore
Degeneration of phrenic motor neurons induces long-term diaphragm deficits following mid-cervical spinal contusion in mice.

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2013: Kunie Ando; Michèle Authelet; Jean-Pierre Brion; Anaïs Chanut; R Dedecker; Pascale LACOR; Jérémie Lavaur; Marie-Claude Potier; Ekaterina Rogaeva; Véronique Sazdovitch; Virginie Stygelbout; Valérie Suain; Charles Duyckaerts
Clathrin adaptor CALM/PICALM is associated with neurofibrillary tangles and is cleaved in Alzheimer's brains.
Acta neuropathologica 2013;125(6):861-78.
2013: Nathalie Pierrot; Bernadette Tasiaux; Donatienne Tyteca; Jean-Pierre Brion; Dominique Campion; Pierre J Courtoy; Ludovic D'auria; Jean-Baptiste Demoulin; Ilse Dewachter; Philippe Gailly; Laetitia El Haylani; Aurélie Hendrickx; Pascal Kienlen-Campard; Annie Laquerrière; Nathalie Muls; Francisca N'Kuli; Jean-Noël Octave
Amyloid precursor protein controls cholesterol turnover needed for neuronal activity.
EMBO molecular medicine 2013;5(4):608-25.
2012: Charles Nicaise; Roland Pochet; Rajarshi Putatunda; Kathleen A Regan; Megan C Wright; Jean-Pierre Brion; David M Frank; Tamara J Hala; Karelle Leroy; Angelo C Lepore
Degeneration of phrenic motor neurons induces long-term diaphragm deficits following mid-cervical spinal contusion in mice.
Journal of neurotrauma 2012;29(18):2748-60.
2012: Miriam Cnop; J Mark Cooper; Chantal Depondt; Décio L Eizirik; Audrey Begu; Jean-Pierre Brion; Anne Clark; Mariana Igoillo-Esteve; Arnulf H Koeppen; Laurence Ladrière; Dionysios Lefkaditis; Piero Marchetti; Ihsane Marhfour; Xavier Moles Lopez; Fabrice Moore; Anyishai E Musuaya; Massimo Pandolfo; Myriam Rai; Anthony H V Schapira; Yasmina Serroukh; Françoise Féry
Central role and mechanisms of β-cell dysfunction and death in friedreich ataxia-associated diabetes.
Annals of neurology 2012;72(6):971-82.
2012: Karelle Leroy; Jean-Noël Octave; Nathalie Pierrot; Valérie Suain; Zehra Yilmaz; Kunie Ando; Michèle Authelet; R Dedecker; Céline Héraud; Vincent Laporte; Jean-Pierre Brion
Lack of tau proteins rescues neuronal cell death and decreases amyloidogenic processing of APP in APP/PS1 mice.
The American journal of pathology 2012;181(6):1928-40.
2012: Charles Nicaise; Jessica L Parker; Megan C Wright; Karelle Leroy; Michèle Authelet; Jean-Pierre Brion; David M Frank; Tamara J Hala; Angelo C Lepore
Phrenic motor neuron degeneration compromises phrenic axonal circuitry and diaphragm activity in a unilateral cervical contusion model of spinal cord injury.
Experimental neurology 2012;235(2):539-52.
2011: Kunie Ando; Karelle Leroy; Céline Héraud; Zehra Yilmaz; Michèle Authelet; Valèrie Suain; Robert De Decker; Jean-Pierre Brion
Accelerated human mutant tau aggregation by knocking out murine tau in a transgenic mouse model.
The American journal of pathology 2011;178(2):803-16.
2010: Kunie Ando; Karelle Leroy; Céline Heraud; Anna Kabova; Zehra Yilmaz; Michèle Authelet; Valèrie Suain; Robert De Decker; Jean-Pierre Brion
Deletion of murine tau gene increases tau aggregation in a human mutant tau transgenic mouse model.
Biochemical Society transactions 2010;38(4):1001-5.
2010: Jean-Pierre Brion; Kunie Ando; Céline Heraud; Karelle Leroy
Modulation of tau pathology in tau transgenic models.
Biochemical Society transactions 2010;38(4):996-1000.
2010: M Morel; Michèle Authelet; R Dedecker; Jean-Pierre Brion
Glycogen synthase kinase-3beta and the p25 activator of cyclin dependent kinase 5 increase pausing of mitochondria in neurons.
Neuroscience 2010;167(4):1044-56.
2010: Laurence Ladrière; Mariana Igoillo-Esteve; Daniel Cunha; Jean-Pierre Brion; Marco Bugliani; Piero Marchetti; Décio L Eizirik; Miriam Cnop
Enhanced signaling downstream of ribonucleic Acid-activated protein kinase-like endoplasmic reticulum kinase potentiates lipotoxic endoplasmic reticulum stress in human islets.
The Journal of clinical endocrinology and metabolism 2010;95(3):1442-9.
2010: Karelle Leroy; Kunie Ando; Céline Héraud; Zehra Yilmaz; Michèle Authelet; Jean-Marie Boeynaems; Luc BUEE; Robert De Decker; Jean-Pierre Brion
Lithium treatment arrests the development of neurofibrillary tangles in mutant tau transgenic mice with advanced neurofibrillary pathology.
Journal of Alzheimer's disease : JAD 2010;19(2):705-19.
2009: Sandra Huysseune; Pascal Kienlen-Campard; Sébastien Hébert; Bernadette Tasiaux; Karelle Leroy; Olivier Devuyst; Jean-Pierre Brion; Bart De Strooper; Jean-Noël Octave
Epigenetic control of aquaporin 1 expression by the amyloid precursor protein.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(12):4158-67.
2009: Aline Vuckovic; Benoît Rondelet; Jean-Pierre Brion; Robert Naeije
Expression of vasoactive intestinal peptide and related receptors in overcirculation-induced pulmonary hypertension in piglets.
Pediatric research 2009;66(4):395-9.
2009: Richard Killick; Georgie Scales; Karelle Leroy; Mirsada Causevic; Claudie Hooper; Elaine E Irvine; Agharul I Choudhury; Laura Drinkwater; Fiona Kerr; Hind Al-Qassab; John Stephenson; Zehra Yilmaz; peter giese; Jean-Pierre Brion; Dominic J Withers; Simon Lovestone
Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice.
Biochemical and biophysical research communications 2009;386(1):257-62.
2009: Alain Boom; Michèle Authelet; R Dedecker; Christelle Frédérick; Roxane Van Heurck; Valéry Daubie; Karelle Leroy; Roland Pochet; Jean-Pierre Brion
Bimodal modulation of tau protein phosphorylation and conformation by extracellular Zn2+ in human-tau transfected cells.
Biochimica et biophysica acta 2009;1793(6):1058-67.
2008: Ingrid Langer; Karelle Leroy; Nathalie Gaspard; Jean-Pierre Brion; Patrick Robberecht
Cell surface targeting of VPAC1 receptors: evidence for implication of a quality control system and the proteasome.
Biochimica et biophysica acta 2008;1783(9):1663-72.
2008: Jean-Pierre Brion
Biological models in frontotemporal dementias.
Handbook of clinical neurology 2008;89():449-55.
2007: Karelle Leroy; Alexis Bretteville; Katharina Schindowski; Emmanuel Gilissen; Michèle Authelet; Robert De Decker; Zehra Yilmaz; Luc BUEE; Jean-Pierre Brion
Early axonopathy preceding neurofibrillary tangles in mutant tau transgenic mice.
The American journal of pathology 2007;171(3):976-92.
2007: Karelle Leroy; Z Yilmaz; Jean-Pierre Brion
Increased level of active GSK-3beta in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration.
Neuropathology and applied neurobiology 2007;33(1):43-55.
2006: Nathalie Pierrot; Susana Ferrao Santos; Christine Feyt; Marina Morel; Jean-Pierre Brion; Jean-Noël Octave
Calcium-mediated transient phosphorylation of tau and amyloid precursor protein followed by intraneuronal amyloid-beta accumulation.
The Journal of biological chemistry 2006;281(52):39907-14.
2006: Katharina Schindowski; Alexis Bretteville; Karelle Leroy; Séverine Bégard; Jean-Pierre Brion; Malika Hamdane; Luc BUEE
Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits.
The American journal of pathology 2006;169(2):599-616.
2006: Jean-Pierre Brion
Immunological demonstration of tau protein in neurofibrillary tangles of Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2006;9(3 Suppl):177-85.
2005: Christine Feyt; Pascal Kienlen-Campard; Karelle Leroy; Francisca N'Kuli; Pierre J Courtoy; Jean-Pierre Brion; Jean-Noël Octave
Lithium chloride increases the production of amyloid-beta peptide independently from its inhibition of glycogen synthase kinase 3.
The Journal of biological chemistry 2005;280(39):33220-7.
2005: Pascal Derkinderen; Timothy M E Scales; Diane P Hanger; Kit-Yi Leung; Helen L Byers; Malcolm A Ward; Christof Lenz; Caroline Price; Ian N Bird; Timothy Perera; Stuart Kellie; Ritchie Williamson; Wendy Noble; Richard A Van Etten; Karelle Leroy; Jean-Pierre Brion; C Hugh Reynolds; Brian H Anderton
Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(28):6584-93.
2004: Charles Debray; Pierre Vereecken; Nathalie Belot; Peggy Teillard; Jean-Pierre Brion; Massimo Pandolfo; Roland Pochet
Multifaceted role of galectin-3 on human glioblastoma cell motility.
Biochemical and biophysical research communications 2004;325(4):1393-8.
2004: Alain Boom; Roland Pochet; Michèle Authelet; Laurent Pradier; Peter Borghgraef; Fred Van Leuven; Claus W Heizmann; Jean-Pierre Brion
Astrocytic calcium/zinc binding protein S100A6 over expression in Alzheimer's disease and in PS1/APP transgenic mice models.
Biochimica et biophysica acta 2004;1742(1-3):161-8.
2004: Allal Boutajangout; Alain Boom; Karelle Leroy; Jean-Pierre Brion
Expression of tau mRNA and soluble tau isoforms in affected and non-affected brain areas in Alzheimer's disease.
FEBS letters 2004;576(1-2):183-9.
2004: Allal Boutajangout; Michèle Authelet; Véronique Blanchard; Nathalie Touchet; Günter Tremp; Laurent Pradier; Jean-Pierre Brion
Characterisation of cytoskeletal abnormalities in mice transgenic for wild-type human tau and familial Alzheimer's disease mutants of APP and presenilin-1.
Neurobiology of disease 2004;15(1):47-60.
2003: Karelle Leroy; Allal Boutajangout; J Richardson; Jean-Noël Octave; Simon Lovestone; Brian H Anderton; Jean-Pierre Brion
Mutant presenilin 1 proteins induce cell death and reduce tau-dependent processes outgrowth.
Neuroscience letters 2003;353(3):226-30.
2002: Diane P Hanger; Graham Gibb; Rohan de Silva; Allal Boutajangout; Jean-Pierre Brion; Tamas Revesz; Andrew J Lees; Brian H Anderton
The complex relationship between soluble and insoluble tau in tauopathies revealed by efficient dephosphorylation and specific antibodies.
FEBS letters 2002;531(3):538-42.
2002: Karelle Leroy; Allal Boutajangout; Michèle Authelet; James R Woodgett; Brian H Anderton; Jean-Pierre Brion
The active form of glycogen synthase kinase-3beta is associated with granulovacuolar degeneration in neurons in Alzheimer's disease.
Acta neuropathologica 2002;103(2):91-9.
2002: Allal Boutajangout; Karelle Leroy; Nathalie Touchet; Michèle Authelet; Véronique Blanchard; Günter Tremp; Laurent Pradier; Jean-Pierre Brion
Increased tau phosphorylation but absence of formation of neurofibrillary tangles in mice double transgenic for human tau and Alzheimer mutant (M146L) presenilin-1.
Neuroscience letters 2002;318(1):29-33.
2001: Richard Killick; CC Pollard; Ayodeji A Asuni; Amritpal Mudher; Jill C Richardson; H T R Rupniak; Paul Sheppard; Ian Varndell; Jean-Pierre Brion; Allan Levey; O A Levy; M Vestling; Richard Frank Cowburn; Simon Lovestone; Brian H Anderton
Presenilin 1 independently regulates beta-catenin stability and transcriptional activity.
The Journal of biological chemistry 2001;276(51):48554-61.
2001: Karelle Leroy; Charles Duyckaerts; L Bovekamp; O Müller; Brian H Anderton; Jean-Pierre Brion
Increase of adenomatous polyposis coli immunoreactivity is a marker of reactive astrocytes in Alzheimer's disease and in other pathological conditions.
Acta neuropathologica 2001;102(1):1-10.
2001: Jean-Pierre Brion; Brian H Anderton; Michèle Authelet; Rejith Dayanandan; Karelle Leroy; Simon Lovestone; Jean-Noël Octave; Laurent Pradier; Nathalie Touchet; Günter Tremp
Neurofibrillary tangles and tau phosphorylation.
Biochemical Society symposium 2001;(67):81-8.
2001: Brian H Anderton; JC Betts; Walter P Blackstock; Jean-Pierre Brion; S Chapman; J Connell; Rejith Dayanandan; Jean-Marc Gallo; Graham Gibb; Diane P Hanger; Michael Hutton; E Kardalinou; Karelle Leroy; Simon Lovestone; TG Mack; C Hugh Reynolds; Marjon van Slegtenhorst
Sites of phosphorylation in tau and factors affecting their regulation.
Biochemical Society symposium 2001;(67):73-80.
2000: Olivier Toussaint; Philippe Baret; Jean-Pierre Brion; Patrick cras; F Collette; P P De Deyn ; V Geenen; Pascal Kienlen-Campard; C Labeur; J J Legros; J Nève; Jean-Noël Octave; G E Piérard; E Salmon; P van den Bosch de Aguilar P; M Van der Linden ; F V Leuven; J Vanfleteren
Experimental gerontology in Belgium: from model organisms to age-related pathologies.
Experimental gerontology 2000;35(8):901-16.
2000: Karelle Leroy; R Menu; J L Conreur; Rejith Dayanandan; Simon Lovestone; Brian H Anderton; Jean-Pierre Brion
The function of the microtubule-associated protein tau is variably modulated by graded changes in glycogen synthase kinase-3beta activity.
FEBS letters 2000;465(1):34-8.
1999: Karelle Leroy; Jean-Pierre Brion
Developmental expression and localization of glycogen synthase kinase-3beta in rat brain.
Journal of chemical neuroanatomy 1999;16(4):279-93.
1999: Declan McLoughlin; NG Irving; Janet Brownlees; Jean-Pierre Brion; Karelle Leroy; Christopher C J Miller
Mint2/X11-like colocalizes with the Alzheimer's disease amyloid precursor protein and is associated with neuritic plaques in Alzheimer's disease.
The European journal of neuroscience 1999;11(6):1988-94.
1999: Simon Lovestone; D R Davis; M T Webster; Stefanie Kaech; Jean-Pierre Brion; Andrew Matus; Brian H Anderton
Lithium reduces tau phosphorylation: effects in living cells and in neurons at therapeutic concentrations.
Biological psychiatry 1999;45(8):995-1003.
1999: Rejith Dayanandan; Marjon van Slegtenhorst; TG Mack; L Ko; Shu-Hui C. Yen; Karelle Leroy; Jean-Pierre Brion; Brian H Anderton; Michael Hutton; Simon Lovestone
Mutations in tau reduce its microtubule binding properties in intact cells and affect its phosphorylation.
FEBS letters 1999;446(2-3):228-32.
1999: Jean-Pierre Brion
[Neurofibrillary tangles and early modification of the neuronal cytoskeleton in Alzheimer's disease and in experimental models].
Bulletin et mémoires de l'Académie royale de médecine de Belgique 1999;154(6 Pt 2):287-94.
1999: Jean-Pierre Brion; Günter Tremp; Jean-Noël Octave
Transgenic expression of the shortest human tau affects its compartmentalization and its phosphorylation as in the pretangle stage of Alzheimer's disease.
The American journal of pathology 1999;154(1):255-70.
1998: AF Macq; Christian Czech; R Essalmani; Jean-Pierre Brion; Anne Maron; Luc Mercken; Laurent Pradier; Jean-Noël Octave
The long term adenoviral expression of the human amyloid precursor protein shows different secretase activities in rat cortical neurons and astrocytes.
The Journal of biological chemistry 1998;273(44):28931-6.
1998: Jean-Pierre Brion
Neurofibrillary tangles and Alzheimer's disease.
European neurology 1998;40(3):130-40.
1998: Jean-Pierre Brion
The role of neurofibrillary tangles in Alzheimer disease.
Acta neurologica Belgica 1998;98(2):165-74.
1998: David Cotter; Robert Kerwin; S al-Sarraji; Jean-Pierre Brion; A Chadwich; Simon Lovestone; Brian H Anderton; Ian Everall
Abnormalities of Wnt signalling in schizophrenia--evidence for neurodevelopmental abnormality.
Neuroreport 1998;9(7):1379-83.
1998: B J Gibb; Jean-Pierre Brion; Janet Brownlees; Brian H Anderton; Christopher C J Miller
Neuropathological abnormalities in transgenic mice harbouring a phosphorylation mutant neurofilament transgene.
Journal of neurochemistry 1998;70(2):492-500.
1998: Jean-Noël Octave; AF Macq; Jean-Pierre Brion
[Molecular biology and Alzheimer's disease: new clues].
Revue neurologique 1998;154 Suppl 2():S75-81.
1997: Janet Brownlees; NG Irving; Jean-Pierre Brion; B J Gibb; U Wagner; J Woodgett; Christopher C J Miller
Tau phosphorylation in transgenic mice expressing glycogen synthase kinase-3beta transgenes.
Neuroreport 1997;8(15):3251-5.
1997: D R Davis; Brian H Anderton; Jean-Pierre Brion; C Hugh Reynolds; Diane P Hanger
Oxidative stress induces dephosphorylation of tau in rat brain primary neuronal cultures.
Journal of neurochemistry 1997;68(4):1590-7.
1996: B Philippe; Jean-Pierre Brion; E Coppens; Jean-Noël Octave
Generation of a monoclonal antibody to the carboxy-terminal domain of tau by immunization with the amino-terminal domain of the amyloid precursor protein.
Journal of neuroscience research 1996;46(6):709-19.
1996: B Hempen; Jean-Pierre Brion
Reduction of acetylated alpha-tubulin immunoreactivity in neurofibrillary tangle-bearing neurons in Alzheimer's disease.
Journal of neuropathology and experimental neurology 1996;55(9):964-72.
1996: Anne Maron; T Gustin; Aude Le-Roux; I Mottet; Jean-François Dedieu; Jean-Pierre Brion; Roger J Demeure; Michel Perricaudet; Jean-Noël Octave
Gene therapy of rat C6 glioma using adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene: long-term follow-up by magnetic resonance imaging.
Gene therapy 1996;3(4):315-22.
1996: Nicholas James; D R Davis; J Sindon; D P Hanger; Jean-Pierre Brion; Christopher C J Miller; M P Rosenberg; Brian H Anderton; F Propst
Neurodegenerative changes including altered tau phosphorylation and neurofilament immunoreactivity in mice transgenic for the serine/threonine kinase Mos.
Neurobiology of aging 1996;17(2):235-41.
1996: Jean-Pierre Brion
The neurobiology of Alzheimer's disease.
Acta clinica Belgica 1996;51(2):80-90.
1995: L Mercken; Jean-Pierre Brion
Phosphorylation of tau protein is not affected in mice lacking apolipoprotein E.
Neuroreport 1995;6(17):2381-4.
1995: Jean-Pierre Brion; A M Couck
Cortical and brainstem-type Lewy bodies are immunoreactive for the cyclin-dependent kinase 5.
The American journal of pathology 1995;147(5):1465-76.
1995: D R Davis; Jean-Pierre Brion; A M Couck; J M Gallo; Diane P Hanger; Kaetan Ladhani; C Lewis; Christopher C J Miller; T Rupniak; C Smith
The phosphorylation state of the microtubule-associated protein tau as affected by glutamate, colchicine and beta-amyloid in primary rat cortical neuronal cultures.
The Biochemical journal 1995;309 ( Pt 3)():941-9.
1995: J P Van Geertruyden; T J Fourez; P Hansen; P E Heimann; Jean-Pierre Brion
Heterotopic brain tissue in the scalp.
British journal of plastic surgery 1995;48(5):332-4.
1995: Jean-Pierre Brion; J Flament-Durand
Distribution and expression of the alpha-tubulin mRNA in the hippocampus and the temporal cortex in Alzheimer's disease.
Pathology, research and practice 1995;191(6):490-8.
1995: Brian H Anderton; Jean-Pierre Brion; A M Couck; D R Davis; J M Gallo; Diane P Hanger; Kaetan Ladhani; D A Latimer; C Lewis; Simon Lovestone
Modulation of PHF-like tau phosphorylation in cultured neurones and transfected cells.
Neurobiology of aging 1995;16(3):389-97; discussion 398-402.
1995: Jean-Pierre Brion; A M Couck; J L Conreur
Calcineurin (phosphatase 2B) is present in neurons containing neurofibrillary tangles and in a subset of senile plaques in Alzheimer's disease.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 1995;4(1):13-21.
1994: Jean-Pierre Brion; J N Octave; A M Couck
Distribution of the phosphorylated microtubule-associated protein tau in developing cortical neurons.
Neuroscience 1994;63(3):895-909.
1994: A M Gillian; Jean-Pierre Brion; Kieran C Breen
Expression of the neural cell adhesion molecule (NCAM) in Alzheimer's disease.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 1994;3(4):283-91.
1994: P Klosen; J N Octave; Jean-Pierre Brion; Ph van den Bosch de Aguilar
Heparin treatment increases 9-kb MAP2 mRNA levels in neuronal cell cultures.
Neuroscience letters 1994;168(1-2):175-80.
1994: Jean-Pierre Brion; A Résibois
A subset of calretinin-positive neurons are abnormal in Alzheimer's disease.
Acta neuropathologica 1994;88(1):33-43.
1993: B Philippe; Jean-Pierre Brion; A F Macq; Jean-Noël Octave
A new monoclonal antibody against the anionic domain of the amyloid precursor protein of Alzheimer's disease.
Neuroreport 1993;5(3):289-92.
1993: Jean-Pierre Brion; C Smith; A M Couck; J M Gallo; Brian H Anderton
Developmental changes in tau phosphorylation: fetal tau is transiently phosphorylated in a manner similar to paired helical filament-tau characteristic of Alzheimer's disease.
Journal of neurochemistry 1993;61(6):2071-80.
1993: Jean-Pierre Brion; A M Couck; J Robertson; T L Loviny; Brian H Anderton
Neurofilament monoclonal antibodies RT97 and 8D8 recognize different modified epitopes in paired helical filament-tau in Alzheimer's disease.
Journal of neurochemistry 1993;60(4):1372-82.
1992: Diane P Hanger; K Hughes; J R Woodgett; Jean-Pierre Brion; Brian H Anderton
Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase.
Neuroscience letters 1992;147(1):58-62.
1992: Jean-Pierre Brion
The pathology of the neuronal cytoskeleton in Alzheimer's disease.
Biochimica et biophysica acta 1992;1160(1):134-42.
1992: Michael Cheetham; Jean-Pierre Brion; Brian H Anderton
Human homologues of the bacterial heat-shock protein DnaJ are preferentially expressed in neurons.
The Biochemical journal 1992;284 ( Pt 2)():469-76.
1992: P Dustin; Jean-Pierre Brion; J Flament-Durand
What's new in the pathology of neuronal cytoskeleton: the significance of neurofibrillary tangles.
Pathology, research and practice 1992;188(1-2):248-53.
1992: Jean-Pierre Brion
[Cellular lesions in Alzheimer's disease: structural and molecular analysis].
Bulletin et mémoires de l'Académie royale de médecine de Belgique 1992;147(11-12):481-9; discussion 490-1.
1991: Jean-Pierre Brion; Diane P Hanger; A M Couck; Brian H Anderton
A68 proteins in Alzheimer's disease are composed of several tau isoforms in a phosphorylated state which affects their electrophoretic mobilities.
The Biochemical journal 1991;279 ( Pt 3)():831-6.
1991: Diane P Hanger; Jean-Pierre Brion; J M Gallo; Nigel J Cairns; P J Luthert; Brian H Anderton
Tau in Alzheimer's disease and Down's syndrome is insoluble and abnormally phosphorylated.
The Biochemical journal 1991;275 ( Pt 1)():99-104.
1991: Jean-Pierre Brion; A M Couck; M Bruce; Brian H Anderton; J Flament-Durand
Synaptophysin and chromogranin A immunoreactivities in senile plaques of Alzheimer's disease.
Brain research 1991;539(1):143-50.
1991: Jean-Pierre Brion; Diane P Hanger; M T Bruce; A M Couck; J Flament-Durand; Brian H Anderton
Tau in Alzheimer neurofibrillary tangles. N- and C-terminal regions are differentially associated with paired helical filaments and the location of a putative abnormal phosphorylation site.
The Biochemical journal 1991;273(Pt 1)():127-33.
1990: P Klosen; Brian H Anderton; Jean-Pierre Brion; Ph van den Bosch de Aguilar
Perikaryal neurofilament phosphorylation in axotomized and 6-OH-dopamine-lesioned CNS neurons.
Brain research 1990;526(2):259-69.
1990: Charles Duyckaerts; P Delaère; JEAN-JACQUES HAUW; A L Abbamondi-Pinto; Sandro Sorbi; I Allen; Jean-Pierre Brion; J Flament-Durand; L Duchen; J Kauss
Rating of the lesions in senile dementia of the Alzheimer type: concordance between laboratories. A European multicenter study under the auspices of EURAGE.
Journal of the neurological sciences 1990;97(2-3):295-323.
1990: D Couchie; F Legay; J Guilleminot; François Lebargy; Jean-Pierre Brion; J Nunez
Expression of Tau protein and Tau mRNA in the cerebellum during axonal outgrowth.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1990;82(3):589-96.
1990: D Langui; Alphonse Probst; Brian H Anderton; Jean-Pierre Brion; J Ulrich
Aluminium-induced tangles in cultured rat neurones. Enhanced effect of aluminium by addition of maltol.
Acta neuropathologica 1990;80(6):649-55.
1989: Jean-Pierre Brion; G Demeurisse; A Capon
Evidence of cortical reorganization in hemiparetic patients.
Stroke; a journal of cerebral circulation 1989;20(8):1079-84.
1989: S Richard; Jean-Pierre Brion; A M Couck; J Flament-Durand
Accumulation of smooth endoplasmic reticulum in Alzheimer's disease: new morphological evidence of axoplasmic flow disturbances.
Journal of submicroscopic cytology and pathology 1989;21(3):461-7.
1989: Jean-Pierre Brion; J Flament-Durand
[Pathology of the cytoskeleton in degenerative dementias].
Acta neurologica Belgica 1989;89(3-4):266-73.
1989: J Flament-Durand; Jean-Pierre Brion
[Cerebral morphological changes in degenerative dementia].
Acta neurologica Belgica 1989;89(3-4):179-85.
1989: P N Leigh; A Dodson; M Swash; Jean-Pierre Brion; Brian H Anderton
Cytoskeletal abnormalities in motor neuron disease. An immunocytochemical study.
Brain : a journal of neurology 1989;112 ( Pt 2)():521-35.
1989: Jean-Pierre Brion; D Power; D Hue; A M Couck; Brian H Anderton; J Flament-Durand
Heterogeneity of ubiquitin immunoreactivity in neurofibrillary tangles of Alzheimer's disease.
Neurochemistry international 1989;14(2):121-8.
1989: Alphonse Probst; Brian H Anderton; Jean-Pierre Brion; J Ulrich
Senile plaque neurites fail to demonstrate anti-paired helical filament and anti-microtubule-associated protein-tau immunoreactive proteins in the absence of neurofibrillary tangles in the neocortex.
Acta neuropathologica 1989;77(4):430-6.
1989: P N Leigh; A Probst; G E Dale; D P Power; Jean-Pierre Brion; A Dodson; Brian H Anderton
New aspects of the pathology of neurodegenerative disorders as revealed by ubiquitin antibodies.
Acta neuropathologica 1989;79(1):61-72.
1989: P Delaère; Charles Duyckaerts; Jean-Pierre Brion; V Poulain; JEAN-JACQUES HAUW
Tau, paired helical filaments and amyloid in the neocortex: a morphometric study of 15 cases with graded intellectual status in aging and senile dementia of Alzheimer type.
Acta neuropathologica 1989;77(6):645-53.
1988: Jean-Pierre Brion; J Guilleminot; J Nunez
Dendritic and axonal distribution of the microtubule-associated proteins MAP2 and tau in the cerebellum of the nervous mutant mouse.
Brain research. Developmental brain research 1988;44(2):221-32.
1988: Charles Duyckaerts; P Delaère; V Poulain; Jean-Pierre Brion; JEAN-JACQUES HAUW
Does amyloid precede paired helical filaments in the senile plaque? A study of 15 cases with graded intellectual status in aging and Alzheimer disease.
Neuroscience letters 1988;91(3):354-9.
1988: Jean-Pierre Brion; J Guilleminot; D Couchie; J Flament-Durand; J Nunez
Both adult and juvenile tau microtubule-associated proteins are axon specific in the developing and adult rat cerebellum.
Neuroscience 1988;25(1):139-46.
1988: D Langui; Brian H Anderton; Jean-Pierre Brion; J Ulrich
Effects of aluminium chloride on cultured cells from rat brain hemispheres.
Brain research 1988;438(1-2):67-76.
1988: P Dustin; Jean-Pierre Brion
[Pathology of the cytoskeleton].
Annales de pathologie 1988;8(1):3-19.
1988: P Dustin; Jean-Pierre Brion; J Flament-Durand
[The cytoskeleton and its pathology].
Bulletin et mémoires de l'Académie royale de médecine de Belgique 1988;143(5-6):308-16.
1988: Alphonse Probst; D Langui; C Lautenschlager; J Ulrich; Jean-Pierre Brion; Brian H Anderton
Progressive supranuclear palsy: extensive neuropil threads in addition to neurofibrillary tangles. Very similar antigenicity of subcortical neuronal pathology in progressive supranuclear palsy and Alzheimer's disease.
Acta neuropathologica 1988;77(1):61-8.
1987: Jean-Pierre Brion; Michael Cheetham; P A Robinson; A M Couck; Brian H Anderton
Isolation of cDNAs coding for epitopes shared by microtubule-associated proteins and neurofibrillary tangle in Alzheimer's disease.
FEBS letters 1987;226(1):28-32.
1987: Jean-Pierre Brion; H Fraser; J Flament-Durand; A G Dickinson
Amyloid scrapie plaques in mice, and Alzheimer senile plaques, share common antigens with tau, a microtubule-associated protein.
Neuroscience letters 1987;78(1):113-8.
1987: J Ulrich; Brian H Anderton; Jean-Pierre Brion; M Euler; Alphonse Probst
Cytoskeletal immunohistochemistry of Alzheimer's disease.
Journal of neural transmission. Supplementum 1987;24():197-204.
1987: J Ulrich; Alphonse Probst; D Langui; Brian H Anderton; Jean-Pierre Brion
Cytoskeletal immunohistochemistry of Alzheimer's dementia and related diseases. A study with monoclonal antibodies.
Pathology and immunopathology research 1987;6(4):273-83.
1987: Brian H Anderton; Jean-Pierre Brion; J Flament-Durand; Margaret Haugh; J Kahn; Christopher C J Miller; A Probst; J Ulrich
Neurofibrillary tangles and the neuronal cytoskeleton.
Journal of neural transmission. Supplementum 1987;24():191-6.
1987: Charles Duyckaerts; Jean-Pierre Brion; JEAN-JACQUES HAUW; J Flament-Durand
Quantitative assessment of the density of neurofibrillary tangles and senile plaques in senile dementia of the Alzheimer type. Comparison of immunocytochemistry with a specific antibody and Bodian's protargol method.
Acta neuropathologica 1987;73(2):167-70.
1986: Jean-Pierre Brion; J Flament-Durand; P Dustin
Alzheimer's disease and tau proteins.
Lancet 1986;2(8515):1098.
1986: P Dustin; Jean-Pierre Brion; J Flament-Durand
[Microtubules in the cellular lesions of Alzheimer's disease].
Bulletin de l'Académie nationale de médecine 1986;170(8):1051-5.
1986: Christopher C J Miller; Jean-Pierre Brion; R Calvert; T K Chin; P A Eagles; M J Downes; J Flament-Durand; M Haugh; J Kahn; A Probst
Alzheimer's paired helical filaments share epitopes with neurofilament side arms.
The EMBO journal 1986;5(2):269-76.
1985: Jean-Pierre Brion; A M Couck; E Passareiro; J Flament-Durand
Neurofibrillary tangles of Alzheimer's disease: an immunohistochemical study.
Journal of submicroscopic cytology 1985;17(1):89-96.
1985: J Flament-Durand; Jean-Pierre Brion
Tanycytes: morphology and functions: a review.
International review of cytology 1985;96():121-55.
1984: Jean-Pierre Brion; A M Couck; J Flament-Durand; J D'Haens; J Mockel
Demonstration of prolactin at the ultrastructural level in a pituitary adenoma by the use of colloidal gold labelling.
Journal of submicroscopic cytology 1984;16(3):555-60.
1984: Ph van den Bosch de Aguilar; C Langhendries-Wéverberg; J Goemaere-Vanneste; J Flament-Durand; Jean-Pierre Brion; A M Couck
Transplantation of human cortex with Alzheimer's disease into rat occipital cortex; a model for the study of Alzheimer disease.
Experientia 1984;40(4):402-3.
1984: Jean-Pierre Brion; A M Couck; J Flament-Durand
Ultrastructural study of enriched fractions of "tangles" from human patients with senile dementia of the Alzheimer type.
Acta neuropathologica 1984;64(2):148-52.
1982: A Lowenthal; J Flament-Durand; D Karcher; M Noppe; Jean-Pierre Brion
Glial cells identified by anti-alpha-albumin (anti-GFA) in human pineal gland.
Journal of neurochemistry 1982;38(3):863-5.
1982: Jean-Pierre Brion; M Depierreux; A M Couck; J Flament-Durand
Transmission and scanning electron-microscopic observations on tanycytes in the mediobasal hypothalamus and the median eminence of adrenalectomized rats.
Cell and tissue research 1982;221(3):643-55.
1982: Jean-Pierre Brion; A M Couck; J Flament-Durand
Intranuclear inclusions in the neurons of senescent rats.
Acta neuropathologica 1982;58(2):107-10.