FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Qi-Zhuang Ye

Research Profile

Chemicals & Drugs

Living Beings

Concepts & Ideas

Genes & Molecular Sequences

Procedures

X Ray Crystallography

Occupations

Drug Design

Co-author Network

Publications

TOP 3
Wei Xu; Jing-Ping Lu; Qi-Zhuang Ye
Structural analysis of bengamide derivatives as inhibitors of methionine aminopeptidases.
Xinjun Zhang; Jose Garcia Abreu; Seong-Moon Cheong; Karla Loureiro Almeida Coburn; Howard C Hang; Bryan T MacDonald; Sasha Singh; Hanno Steen; Qi-Zhuang Ye; Chika Yokota; Mingzi M Zhang; Xi He
Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation.
Min Li; Andreas Vogt; Qi-Zhuang Ye; Xi Chen; Xiao-Ming Yin
A high-throughput FRET-based assay for determination of Atg4 activity.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Qi-Zhuang Ye (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2012: Wei Xu; Jing-Ping Lu; Qi-Zhuang Ye
Structural analysis of bengamide derivatives as inhibitors of methionine aminopeptidases.
Journal of medicinal chemistry 2012;55(18):8021-7.
2012: Xinjun Zhang; Jose Garcia Abreu; Seong-Moon Cheong; Karla Loureiro Almeida Coburn; Howard C Hang; Bryan T MacDonald; Sasha Singh; Hanno Steen; Qi-Zhuang Ye; Chika Yokota; Mingzi M Zhang; Xi He
Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation.
Cell 2012;149(7):1565-77.
2012: Min Li; Andreas Vogt; Qi-Zhuang Ye; Xi Chen; Xiao-Ming Yin
A high-throughput FRET-based assay for determination of Atg4 activity.
Autophagy 2012;8(3):401-12.
2012: Qi Zhang; Derong Ding; Qi-Zhuang Ye; Shelya X Zeng; Hua lu
Structure and activity analysis of Inauhzin analogs as novel antitumor compounds that induce p53 and inhibit cell growth.
PloS one 2012;7(10):e46294.
2012: Jing-Ping Lu; Xiu-Hua Yuan; Qi-Zhuang Ye
Structural analysis of inhibition of Mycobacterium tuberculosis methionine aminopeptidase by bengamide derivatives.
European journal of medicinal chemistry 2012;47(1):479-84.
2011: Wen-Long Wang; Sergio C Chai; Qi-Zhuang Ye
Synthesis and biological evaluation of salicylate-based compounds as a novel class of methionine aminopeptidase inhibitors.
Bioorganic & medicinal chemistry letters 2011;21(23):7151-4.
2011: Sergio C Chai; De-Rong Ding; Wen-Long Wang; Qi-Zhuang Ye
Growth inhibition of Escherichia coli and methicillin-resistant Staphylococcus aureus by targeting cellular methionine aminopeptidase.
European journal of medicinal chemistry 2011;46(8):3537-40.
2011: Jing-Ping Lu; Xiu-Hua Yuan; Hai Yuan; Wen-Long Wang; Baojie Wan; Scott Franzblau; Qi-Zhuang Ye
Inhibition of Mycobacterium tuberculosis methionine aminopeptidases by bengamide derivatives.
ChemMedChem 2011;6(6):1041-8.
2011: Hai Yuan; Sergio C Chai; Christopher K Lam; H Howard Xu; Qi-Zhuang Ye
Two methionine aminopeptidases from Acinetobacter baumannii are functional enzymes.
Bioorganic & medicinal chemistry letters 2011;21(11):3395-8.
2010: Jing-Ping Lu; Qi-Zhuang Ye
Expression and characterization of Mycobacterium tuberculosis methionine aminopeptidase type 1a.
Bioorganic & medicinal chemistry letters 2010;20(9):2776-9.
2010: Sergio C Chai; Qi-Zhuang Ye
A cell-based assay that targets methionine aminopeptidase in a physiologically relevant environment.
Bioorganic & medicinal chemistry letters 2010;20(7):2129-32.
2010: Jing-Ping Lu; Sergio C Chai; Qi-Zhuang Ye
Catalysis and inhibition of Mycobacterium tuberculosis methionine aminopeptidase.
Journal of medicinal chemistry 2010;53(3):1329-37.
2009: Sergio C Chai; Qi-Zhuang Ye
Metal-mediated inhibition is a viable approach for inhibiting cellular methionine aminopeptidase.
Bioorganic & medicinal chemistry letters 2009;19(24):6862-4.
2009: Sergio C Chai; Jing-Ping Lu; Qi-Zhuang Ye
Determination of binding affinity of metal cofactor to the active site of methionine aminopeptidase based on quantitation of functional enzyme.
Analytical biochemistry 2009;395(2):263-4.
2009: Arindam Talukdar; Meghan Breen; Adelbert Bacher; Boris Illarionov; Markus Fischer; Gunda I Georg; Qi-Zhuang Ye; Mark Cushman
Discovery and development of a small molecule library with lumazine synthase inhibitory activity.
The Journal of organic chemistry 2009;74(15):5123-34.
2009: Yujie Zhao; Adelbert Bacher; Boris Illarionov; Markus Fischer; Gunda I Georg; Qi-Zhuang Ye; Phillip E Fanwick; Scott Franzblau; Baojie Wan; Mark Cushman
Discovery and development of the covalent hydrates of trifluoromethylated pyrazoles as riboflavin synthase inhibitors with antibiotic activity against Mycobacterium tuberculosis.
The Journal of organic chemistry 2009;74(15):5297-303.
2009: Wen-Long Wang; Sergio C Chai; Qi-Zhuang Ye
Synthesis and structure-function analysis of Fe(II)-form-selective antibacterial inhibitors of Escherichia coli methionine aminopeptidase.
Bioorganic & medicinal chemistry letters 2009;19(4):1080-3.
2009: Sergio C Chai; Qi-Zhuang Ye
Analysis of the stoichiometric metal activation of methionine aminopeptidase.
BMC biochemistry 2009;10():32.
2008: Wen-Long Wang; Sergio C Chai; Min Huang; Hong-Zhen He; Thomas D Hurley; Qi-Zhuang Ye
Discovery of inhibitors of Escherichia coli methionine aminopeptidase with the Fe(II)-form selectivity and antibacterial activity.
Journal of medicinal chemistry 2008;51(19):6110-20.
2008: Sergio C Chai; Wen-Long Wang; Qi-Zhuang Ye
FE(II) is the native cofactor for Escherichia coli methionine aminopeptidase.
The Journal of biological chemistry 2008;283(40):26879-85.
2008: Punitha Vedantham; Jennifer M Guerra; Frank Schoenen; Min Huang; Parul J Gor; Gunda I Georg; Jenna L Wang; Benjamin Neuenswander; Gerald H Lushington; Lester A Mitscher; Qi-Zhuang Ye; Paul R Hanson
Ionic immobilization, diversification, and release: application to the generation of a library of methionine aminopeptidase inhibitors.
Journal of combinatorial chemistry 2008;10(2):185-94.
2008: Punitha Vedantham; Mianji Zhang; Parul J Gor; Min Huang; Gunda I Georg; Gerald H Lushington; Lester A Mitscher; Qi-Zhuang Ye; Paul R Hanson
Studies towards the synthesis of methionine aminopeptidase inhibitors: diversification utilizing a ROMP-derived coupling reagent.
Journal of combinatorial chemistry 2008;10(2):195-203.
2007: Min Huang; Sheng-Xue Xie; Ze-Qiang Ma; Qing-Qing Huang; Fa-Jun Nan; Qi-Zhuang Ye
Inhibition of monometalated methionine aminopeptidase: inhibitor discovery and crystallographic analysis.
Journal of medicinal chemistry 2007;50(23):5735-42.
2007: Yanlei Zhang; Boris Illarionov; Adelbert Bacher; Markus Fischer; Gunda I Georg; Qi-Zhuang Ye; David VanderVelde; Phillip E Fanwick; Yunlong Song; Mark Cushman
A novel lumazine synthase inhibitor derived from oxidation of 1,3,6,8-tetrahydroxy-2,7-naphthyridine to a tetraazaperylenehexaone derivative.
The Journal of organic chemistry 2007;72(8):2769-76.
2007: Lakshmi Galam; M Kyle Hadden; Zeqiang Ma; Qi-Zhuang Ye; Bo-Geon Yun; Brian S J Blagg; Robert L Matts
High-throughput assay for the identification of Hsp90 inhibitors based on Hsp90-dependent refolding of firefly luciferase.
Bioorganic & medicinal chemistry 2007;15(5):1939-46.
2007: Ze-Qiang Ma; Sheng-Xue Xie; Qing-Qing Huang; Fa-Jun Nan; Thomas D Hurley; Qi-Zhuang Ye
Structural analysis of inhibition of E. coli methionine aminopeptidase: implication of loop adaptability in selective inhibition of bacterial enzymes.
BMC structural biology 2007;7():84.
2007: Sheng-Xue Xie; Fabian Schalkhausser; Qi-Zhuang Ye; Roland Seifert; Armin Buschauer
Effects of impromidine- and arpromidine-derived guanidines on recombinant human and guinea pig histamine H1 and H2 receptors.
Archiv der Pharmazie 2007;340(1):9-16.
2006: Sheng-Xue Xie; Georgiana Petrache; Erich Schneider; Qi-Zhuang Ye; Günther Bernhardt; Roland Seifert; Armin Buschauer
Synthesis and pharmacological characterization of novel fluorescent histamine H2-receptor ligands derived from aminopotentidine.
Bioorganic & medicinal chemistry letters 2006;16(15):3886-90.
2006: Qi-Zhuang Ye; Sheng-Xue Xie; Ze-Qiang Ma; Min Huang; Robert P Hanzlik
Structural basis of catalysis by monometalated methionine aminopeptidase.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(25):9470-5.
2006: Sheng-Xue Xie; Anja Kraus; Prasanta Ghorai; Qi-Zhuang Ye; Sigurd Elz; Armin Buschauer; Roland Seifert
N1-(3-cyclohexylbutanoyl)-N2-[3-(1H-imidazol-4-yl)propyl]guanidine (UR-AK57), a potent partial agonist for the human histamine H1- and H2-receptors.
The Journal of pharmacology and experimental therapeutics 2006;317(3):1262-8.
2006: Christopher Avila; M Kyle Hadden; Zeqiang Ma; Boris A Kornilayev; Qi-Zhuang Ye; Brian S J Blagg
High-throughput screening for Hsp90 ATPase inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(11):3005-8.
2006: Sheng-Xue Xie; Wei Jun Huang; Ze-Qiang Ma; Min Huang; Robert P Hanzlik; Qi-Zhuang Ye
Structural analysis of metalloform-selective inhibition of methionine aminopeptidase.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 4):425-32.
2006: Sheng-Xue Xie; Prasanta Ghorai; Qi-Zhuang Ye; Armin Buschauer; Roland Seifert
Probing ligand-specific histamine H1- and H2-receptor conformations with NG-acylated Imidazolylpropylguanidines.
The Journal of pharmacology and experimental therapeutics 2006;317(1):139-46.
2006: Jianwen Fang; Yinghua Dong; Gerald H Lushington; Qi-Zhuang Ye; Gunda I Georg
Support vector machines in HTS data mining: Type I MetAPs inhibition study.
Journal of biomolecular screening 2006;11(2):138-44.
2006: Min Huang; Sheng-Xue Xie; Ze-Qiang Ma; Robert P Hanzlik; Qi-Zhuang Ye
Metal mediated inhibition of methionine aminopeptidase by quinolinyl sulfonamides.
Biochemical and biophysical research communications 2006;339(2):506-13.
2005: Qing-Qing Huang; Min Huang; Fa-Jun Nan; Qi-Zhuang Ye
Metalloform-selective inhibition: synthesis and structure-activity analysis of Mn(II)-form-selective inhibitors of Escherichia coli methionine aminopeptidase.
Bioorganic & medicinal chemistry letters 2005;15(24):5386-91.
2005: Yong-Mei Cui; Qing-Qing Huang; Jie Xu; Ling-Ling Chen; Jing-Ya Li; Qi-Zhuang Ye; Jia Li; Fa-Jun Nan
Identification of potent type I MetAPs inhibitors by simple bioisosteric replacement. Part 2: SAR studies of 5-heteroalkyl substituted TCAT derivatives.
Bioorganic & medicinal chemistry letters 2005;15(18):4130-5.
2005: Yong-Mei Cui; Qing-Qing Huang; Jie Xu; Ling-Ling Chen; Jing-Ya Li; Qi-Zhuang Ye; Jia Li; Fa-Jun Nan
Identification of potent type I MetAP inhibitors by simple bioisosteric replacement. Part 1: Synthesis and preliminary SAR studies of thiazole-4-carboxylic acid thiazol-2-ylamide derivatives.
Bioorganic & medicinal chemistry letters 2005;15(16):3732-6.
2005: Jinhua Chen; Boris Illarionov; Adelbert Bacher; Markus Fischer; Ilka Haase; Gunda I Georg; Qi-Zhuang Ye; Zeqiang Ma; Mark Cushman
A high-throughput screen utilizing the fluorescence of riboflavin for identification of lumazine synthase inhibitors.
Analytical biochemistry 2005;338(1):124-30.
2005: Qun-Li Luo; Jing-Ya Li; Ling-Ling Chen; Jia Li; Qi-Zhuang Ye; Fa-Jun Nan
Inhibitors of type I MetAPs containing pyridine-2-carboxylic acid thiazol-2-ylamide. Part 2: SAR studies on the pyridine ring 3-substituent.
Bioorganic & medicinal chemistry letters 2005;15(3):639-44.
2005: Qun-Li Luo; Jing-Ya Li; Zhi-Ying Liu; Ling-Ling Chen; Jia Li; Qi-Zhuang Ye; Fa-Jun Nan
Inhibitors of type I MetAPs containing pyridine-2-carboxylic acid thiazol-2-ylamide. Part 1: SAR studies on the determination of the key scaffold.
Bioorganic & medicinal chemistry letters 2005;15(3):635-8.
2005: Gale Haslam; Mark Richter; Diane Wyatt; Qi-Zhuang Ye; Paul Kitos
Estimating the number of viable animal cells in multiwell culture--a tetrazolium-based assay.
Analytical biochemistry 2005;336(2):187-95.
2004: Qi-Zhuang Ye; Sheng-Xue Xie; Min Huang; Wei-Jun Huang; Jing-Ping Lu; Ze-Qiang Ma
Metalloform-selective inhibitors of escherichia coli methionine aminopeptidase and X-ray structure of a Mn(II)-form enzyme complexed with an inhibitor.
Journal of the American Chemical Society 2004;126(43):13940-1.
2004: Ling-ling Chen; Jia Li; Jing-Ya Li; Qun-Li Luo; Wei-feng Mao; Qiang Shen; Fa-Jun Nan; Qi-Zhuang Ye
Type I methionine aminopeptidase from Saccharomyces cerevisiae is a potential target for antifungal drug screening.
Acta pharmacologica Sinica 2004;25(7):907-14.
2004: Jing-Ya Li; Ling-Ling Chen; Yong-Mei Cui; Qun-Li Luo; Min Gu; Fa-Jun Nan; Qi-Zhuang Ye
Characterization of full length and truncated type I human methionine aminopeptidases expressed from Escherichia coli.
Biochemistry 2004;43(24):7892-8.
2004: Yong-Mei Cui; Jing-Ya Li; Ling-Ling Chen; Jia Li; Qi-Zhuang Ye; Fa-Jun Nan
Design and synthesis of chromogenic thiopeptolide substrates as MetAPs active site probes.
Bioorganic & medicinal chemistry 2004;12(11):2853-61.
2004: Jing-Ya Li; Yong-Mei Cui; Ling-Ling Chen; Min Gu; Jia Li; Fa-Jun Nan; Qi-Zhuang Ye
Mutations at the S1 sites of methionine aminopeptidases from Escherichia coli and Homo sapiens reveal the residues critical for substrate specificity.
The Journal of biological chemistry 2004;279(20):21128-34.
2003: Jing-Ya Li; Ling-Ling Chen; Yong-Mei Cui; Qun-Li Luo; Jia Li; Fa-Jun Nan; Qi-Zhuang Ye
Specificity for inhibitors of metal-substituted methionine aminopeptidase.
Biochemical and biophysical research communications 2003;307(1):172-9.
2003: Qun-Li Luo; Jing-Ya Li; Zhi-Ying Liu; Ling-Ling Chen; Jia Li; Zhen Qian; Qiang Shen; Yu Li; Gerald H Lushington; Qi-Zhuang Ye; Fa-Jun Nan
Discovery and structural modification of inhibitors of methionine aminopeptidases from Escherichia coli and Saccharomyces cerevisiae.
Journal of medicinal chemistry 2003;46(13):2631-40.
2003: Donghang Cheng; Qiang Shen; Fa-Jun Nan; Zhen Qian; Qi-Zhuang Ye
Purification and characterization of catalytic domains of gelatinase A with or without fibronectin insert for high-throughput inhibitor screening.
Protein expression and purification 2003;27(1):63-74.
2002: Zhi-Yu Shao; Jin-Na Cai; Qi-Zhuang Ye; Yue-Wei Guo
Crassicaulisine, a new sulphonoglycolipid from the red alga Chondria crassicaulis Harv.
Journal of Asian natural products research 2002;4(3):205-9.
2002: Dong-Hang Cheng; Qiang Shen; Jing Qian; Zhen Qian; Qi-Zhuang Ye
Expression and purification of catalytic domain of human macrophage elastase for high throughput inhibitor screening.
Acta pharmacologica Sinica 2002;23(2):143-51.
2002: Shu-Fei Zhuang; Cai-Hong Zhou; Jing Qian; Zhen Qian; Masabumi Shibuya; Qi-Zhuang Ye
A new model for random screening inhibitors of vascular endothelial growth factor receptor 1 kinase.
Acta pharmacologica Sinica 2002;23(2):117-23.
2002: Shu-Fei Zhuang; Qi-Zhuang Ye
[Cloning, expression and characterization of human vascular endothelial growth factor receptor 1 tyrosine kinase].
Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica 2002;34(1):39-44.
2001: Jing Qian; Cai-Hong Zhou; Zhen Qian; Fa-Jun Nan; Qi-Zhuang Ye
Development of a K562 cell-based assay for screening anticancer agents.
Acta pharmacologica Sinica 2001;22(9):821-6.
2000: Qi-Zhuang Ye; Fa-Jun Nan; L Y Hu; Z Qian; J Qian
High-throughput screening for human collagenase 1 inhibitors.
Acta pharmacologica Sinica 2000;21(11):1021-6.