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William Brissette

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Erin E Matthews; Lawrence A Reiter; Julia M Rogers; Damien Thévenin; William H Brissette; Lisa Gotow; Paul D Lira; Donald M Engelman
Thrombopoietin receptor activation: transmembrane helix dimerization, rotation, and allosteric modulation.
Amy S Antipas; Laura C Blumberg; William H Brissette; Matthew F Brown; Jeffrey M Casavant; Jonathan L Doty; James Driscoll; Thomas M Harris; Christopher S Jones; Sandra P McCurdy; Eric McElroy; Mark Mitton-Fry; Michael J Munchhof; David A Reim; Lawrence A Reiter; Sharon L Ripp; Andrei Shavnya; Marc I Smeets; Kristen A Trevena
Structure-activity relationships and hepatic safety risks of thiazole agonists of the thrombopoietin receptor.
Michael J Munchhof; Amy S Antipas; Laura C Blumberg; William H Brissette; Matthew F Brown; Jeffrey M Casavant; Jonathan L Doty; James P Driscoll; Thomas M Harris; Lilli A Wolf-Gouveia; Christopher S Jones; Qifang Li; Robert G Linde; Paul D Lira; Anthony Marfat; Eric McElroy; Mark Mitton-Fry; Sandra P McCurdy; Lawrence A Reiter; Sharon L Ripp; Andrei Shavnya; Lisa M Thomasco; Kristen A Trevena
The identification of orally bioavailable thrombopoietin agonists.

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All Publications

2011: Erin E Matthews; Lawrence A Reiter; Julia M Rogers; Damien Thévenin; William H Brissette; Lisa Gotow; Paul D Lira; Donald M Engelman
Thrombopoietin receptor activation: transmembrane helix dimerization, rotation, and allosteric modulation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(7):2234-44.
2010: Amy S Antipas; Laura C Blumberg; William H Brissette; Matthew F Brown; Jeffrey M Casavant; Jonathan L Doty; James Driscoll; Thomas M Harris; Christopher S Jones; Sandra P McCurdy; Eric McElroy; Mark Mitton-Fry; Michael J Munchhof; David A Reim; Lawrence A Reiter; Sharon L Ripp; Andrei Shavnya; Marc I Smeets; Kristen A Trevena
Structure-activity relationships and hepatic safety risks of thiazole agonists of the thrombopoietin receptor.
Bioorganic & medicinal chemistry letters 2010;20(14):4069-72.
2009: Michael J Munchhof; Amy S Antipas; Laura C Blumberg; William H Brissette; Matthew F Brown; Jeffrey M Casavant; Jonathan L Doty; James P Driscoll; Thomas M Harris; Lilli A Wolf-Gouveia; Christopher S Jones; Qifang Li; Robert G Linde; Paul D Lira; Anthony Marfat; Eric McElroy; Mark Mitton-Fry; Sandra P McCurdy; Lawrence A Reiter; Sharon L Ripp; Andrei Shavnya; Lisa M Thomasco; Kristen A Trevena
The identification of orally bioavailable thrombopoietin agonists.
Bioorganic & medicinal chemistry letters 2009;19(5):1428-30.
2008: Lawrence A Reiter; Christopher S Jones; William H Brissette; Sandra P McCurdy; Yuriy A Abramov; Jon Bordner; Frank M DiCapua; Michael J Munchhof; Diane M Rescek; Ivan J Samardjiev; Jane M Withka
Molecular features crucial to the activity of pyrimidine benzamide-based thrombopoietin receptor agonists.
Bioorganic & medicinal chemistry letters 2008;18(9):3000-6.
2007: Lawrence A Reiter; Chakrapani Subramanyam; Emilio J Mangual; Christopher S Jones; Marc I Smeets; William H Brissette; Sandra P McCurdy; Paul D Lira; Robert G Linde; Qifang Li; Fangning Zhang; Amy S Antipas; Laura C Blumberg; Jonathan L Doty; James P Driscoll; Michael J Munchhof; Sharon L Ripp; Andrei Shavnya; Richard M Shepard; Diana Sperger; Lisa M Thomasco; Kristen A Trevena; Lilli A Wolf-Gouveia; Liling Zhang
Pyrimidine benzamide-based thrombopoietin receptor agonists.
Bioorganic & medicinal chemistry letters 2007;17(19):5447-54.
2007: Matthew F Brown; Kevin Bahnck; Laura C Blumberg; William H Brissette; Sara A Burrell; James P Driscoll; Flavia Fedeles; Michael B Fisher; Robert S Foti; Ronald P Gladue; Aikomari Guzman-Martinez; Matthew M Hayward; Paul D Lira; Brett M Lillie; Yi Lu; Greg D Lundquist; Eric B McElroy; Molly A McGlynn; Timothy J Paradis; Christopher S Poss; James H Roache; Andrei Shavnya; Richard M Shepard; Kristen A Trevena; Laurie A Tylaska
Piperazinyl CCR1 antagonists--optimization of human liver microsome stability.
Bioorganic & medicinal chemistry letters 2007;17(11):3109-12.
2005: Dominic C Borie; Michael J Larson; Mona G Flores; Andrew Campbell; Geraldine Rousvoal; Sally Zhang; John P Higgins; Douglas J Ball; Elizabeth M Kudlacz; William H Brissette; Eileen A Elliott; Bruce A Reitz; Paul Changelian
Combined use of the JAK3 inhibitor CP-690,550 with mycophenolate mofetil to prevent kidney allograft rejection in nonhuman primates.
Transplantation 2005;80(12):1756-64.
2005: Dominic C Borie; Paul Changelian; Michael J Larson; Ming-Sing Si; Ricardo Paniagua; John P Higgins; Bari Holm Nazario; Andrew Campbell; Macy Lau; Sally Zhang; Mona G Flores; Geraldine Rousvoal; Jennifer Hawkins; Douglas A Ball; Elizabeth M Kudlacz; William H Brissette; Eileen A Elliott; Bruce A Reitz; randall morris
Immunosuppression by the JAK3 inhibitor CP-690,550 delays rejection and significantly prolongs kidney allograft survival in nonhuman primates.
Transplantation 2005;79(7):791-801.
2004: Matthew F Brown; Mike Avery; William H Brissette; J H Chang; Kevin Colizza; Maryrose Conklyn; Amy P DiRico; Ronald P Gladue; John C Kath; Suzanne S Krueger; Paul D Lira; Brett M Lillie; Greg D Lundquist; Erin N Mairs; Eric B McElroy; Molly A McGlynn; Timothy J Paradis; Christopher S Poss; Michelle I Rossulek; Richard M Shepard; Jeff Sims; Timothy J Strelevitz; Susan Truesdell; Laurie A Tylaska; Kwansik Yoon; Deye Zheng
Novel CCR1 antagonists with improved metabolic stability.
Bioorganic & medicinal chemistry letters 2004;14(9):2175-9.
2004: John C Kath; William H Brissette; Matthew F Brown; Maryrose Conklyn; Amy P DiRico; Peter Dorff; Ronald P Gladue; Brett M Lillie; Paul D Lira; Erin N Mairs; William Martin; Eric B McElroy; Molly A McGlynn; Timothy J Paradis; Christopher S Poss; Ingrid A Stock; Laurie A Tylaska; Deye Zheng
Potent small molecule CCR1 antagonists.
Bioorganic & medicinal chemistry letters 2004;14(9):2169-73.
2004: Elizabeth M Kudlacz; Bret Daren Perry; Perry Sawyer; Maryrose Conklyn; Sandra McCurdy; William H Brissette; Mark Flanagan And; Paul Changelian
The novel JAK-3 inhibitor CP-690550 is a potent immunosuppressive agent in various murine models.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2004;4(1):51-7.
2003: Ronald P Gladue; Laurie A Tylaska; William H Brissette; Paul D Lira; John C Kath; Christopher S Poss; Matthew F Brown; Timothy J Paradis; Maryrose Conklyn; Kevin Ogborne; Molly A McGlynn; Brett M Lillie; Amy P DiRico; Erin N Mairs; Eric B McElroy; William Martin; Ingrid A Stock; Richard M Shepard; Henry J Showell; Kuldeep S Neote
CP-481,715, a potent and selective CCR1 antagonist with potential therapeutic implications for inflammatory diseases.
The Journal of biological chemistry 2003;278(42):40473-80.
2002: Jeffrey M Labasi; Nina Petrushova; Carol Donovan; Sandra McCurdy; Paul D Lira; Mary M Payette; William H Brissette; Joan R Wicks; Laurent P Audoly; Christopher A Gabel
Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(12):6436-45.
2001: Karen Honey; M Duff; Courtney Beers; William H Brissette; Eileen A Elliott; Christoph Peters; Maja Maric; P Cresswell; Alexander Y Rudensky
Cathepsin S regulates the expression of cathepsin L and the turnover of gamma-interferon-inducible lysosomal thiol reductase in B lymphocytes.
The Journal of biological chemistry 2001;276(25):22573-8.
2001: Robin T Nelson; J Boyd; Ronald P Gladue; Timothy J Paradis; R Thomas; A C Cunningham; Paul D Lira; William H Brissette; L Hayes; L M Hames; Kuldeep S Neote; Shaun R McColl
Genomic organization of the CC chemokine mip-3alpha/CCL20/larc/exodus/SCYA20, showing gene structure, splice variants, and chromosome localization.
Genomics 2001;73(1):28-37.
1999: P Guan; A H Burghes; A Cunningham; Paul D Lira; William H Brissette; Kuldeep S Neote; Shaun R McColl
Genomic organization and biological characterization of the novel human CC chemokine DC-CK-1/PARC/MIP-4/SCYA18.
Genomics 1999;56(3):296-302.
1999: Terry Nakagawa; William H Brissette; Paul D Lira; Richard J Griffiths; Nina Petrushova; J Stock; John McNeish; S E Eastman; E D Howard; Sally R Clarke; E F Rosloniec; Eileen A Elliott; Alexander Y Rudensky
Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice.
Immunity 1999;10(2):207-17.