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Jwu-Lai Yeh

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Jwu-Lai Yeh; Ing-Jun Chen; Jong-Hau Hsu; Jhy-Chong Liang; Shu-Fen Liou
Lercanidipine and labedipinedilol--a attenuate lipopolysaccharide/interferon-γ-induced inflammation in rat vascular smooth muscle cells through inhibition of HMGB1 release and MMP-2, 9 activities.
Kung-Kai Kuo; C P Liu; C J Tseng; Bin-Nan Wu; Jwu-Lai Yeh; C Y Chai; E Y Chiu; Ing-Jun Chen
No donor KMUP-1 improves hepatic ischemia-reperfusion and hypoxic cell injury by inhibiting oxidative stress and pro-inflammatory signaling.
Jwu-Lai Yeh; Jong-Hau Hsu; Chung-Pin Liu; Ching-Jiunn Tseng; Yi-Ya Wang; Jiunn-Ren Wu; Ping-Ju Wu; Ing-Jun Chen
KMUP-1 inhibits hypertension-induced left ventricular hypertrophy through regulation of nitric oxide synthases, ERK1/2, and calcineurin.

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2013: Jwu-Lai Yeh; Ing-Jun Chen; Jong-Hau Hsu; Jhy-Chong Liang; Shu-Fen Liou
Lercanidipine and labedipinedilol--a attenuate lipopolysaccharide/interferon-γ-induced inflammation in rat vascular smooth muscle cells through inhibition of HMGB1 release and MMP-2, 9 activities.
Atherosclerosis 2013;226(2):364-72.
2013: Kung-Kai Kuo; C P Liu; C J Tseng; Bin-Nan Wu; Jwu-Lai Yeh; C Y Chai; E Y Chiu; Ing-Jun Chen
No donor KMUP-1 improves hepatic ischemia-reperfusion and hypoxic cell injury by inhibiting oxidative stress and pro-inflammatory signaling.
International journal of immunopathology and pharmacology 2013;26(1):93-106.
2012: Jwu-Lai Yeh; Jong-Hau Hsu; Chung-Pin Liu; Ching-Jiunn Tseng; Yi-Ya Wang; Jiunn-Ren Wu; Ping-Ju Wu; Ing-Jun Chen
KMUP-1 inhibits hypertension-induced left ventricular hypertrophy through regulation of nitric oxide synthases, ERK1/2, and calcineurin.
The Kaohsiung journal of medical sciences 2012;28(11):567-76.
2012: Chung-Pin Liu; Bin-Nan Wu; Jwu-Lai Yeh; Chee-Yin Chai; Zen-Kong Dai; Chung-Han Hsieh; Ing-Jun Chen
Inhaled KMUP-1 Prevents Allergic Pulmonary Vascular Inflammation and Remodeling via NO and Suppressed MMP-9 and ICAM-1/VCAM-1.
Inflammation & allergy drug targets 2012;11(4):251-61.
2012: Shu-Fen Liou; Jiunn-Ren Wu; Ing-Jun Chen; Jong-Hau Hsu; Hung-Jen Ke; Jyh-Chong Liang; Jwu-Lai Yeh
San-Huang-Xie-Xin-Tang protects cardiomyocytes against hypoxia/reoxygenation injury via inhibition of oxidative stress-induced apoptosis.
Journal of natural medicines 2012;66(2):311-20.
2011: Jong-Hau Hsu; Shu-Fen Liou; Jiunn-Ren Wu; Huai-Min Chen; Ing-Jun Chen; Zen-Kong Dai; Jwu-Lai Yeh
Labedipinedilol-A prevents lysophosphatidylcholine-induced vascular smooth muscle cell death through reducing reactive oxygen species production and anti-apoptosis.
Atherosclerosis 2011;217(2):379-86.
2011: Jwu-Lai Yeh; Bin-Nan Wu; Jiunn-Ren Wu; Ing-Jun Chen; Y S Hong; Jong-Hau Hsu; Jhy-Chong Liang; Shu-Fen Liou
Eugenolol and glyceryl-isoeugenol suppress LPS-induced iNOS expression by down-regulating NF-kappaB AND AP-1 through inhibition of MAPKS and AKT/IkappaBalpha signaling pathways in macrophages.
International journal of immunopathology and pharmacology 2011;24(2):345-56.
2011: Shu-Fen Liou; Ing-Jun Chen; Jong-Hau Hsu; Hung-Jen Ke; Jyh-Chong Liang; Hung-Hong Lin; Jwu-Lai Yeh
San-Huang-Xie-Xin-Tang Prevents Rat Hearts from Ischemia/Reperfusion-Induced Apoptosis through eNOS and MAPK Pathways.
Evidence-based complementary and alternative medicine : eCAM 2011;2011():915051.
2011: Chung-Pin Liu; Jwu-Lai Yeh; Bin-Nan Wu; Chee-Yin Chai; Ing-Jun Chen; Wen-Ter Lai
KMUP-3 attenuates ventricular remodelling after myocardial infarction through eNOS enhancement and restoration of MMP-9/TIMP-1 balance.
British journal of pharmacology 2011;162(1):126-35.
2011: Zen-Kong Dai; Bin-Nan Wu; I-Chen Chen; Chee-Yin Chai; Jiunn-Ren Wu; Shah-Hwa Chou; Jwu-Lai Yeh; Ing-Jun Chen; Mian-Shin Tan
Attenuation of pulmonary hypertension secondary to left ventricular dysfunction in the rat by Rho-kinase inhibitor fasudil.
Pediatric pulmonology 2011;46(1):45-59.
2010: Hui-Hsuan Chung; Zen-Kong Dai; Bin-Nan Wu; Jwu-Lai Yeh; Chee-Yin Chai; Koung-Shing Chu; Chung-Pin Liu; Ing-Jun Chen
KMUP-1 inhibits pulmonary artery proliferation by targeting serotonin receptors/transporter and NO synthase, inactivating RhoA and suppressing AKT/ERK phosphorylation.
Vascular pharmacology 2010;53(5-6):239-49.
2010: Zen-Kong Dai; Chong-Chao Hsieh; Chee-Yin Chai; Jiunn-Ren Wu; Arco Y Jeng; Shah-Hwa Chou; Bin-Nan Wu; Jwu-Lai Yeh; Ing-Jun Chen; Mian-Shin Tan
Protective effects of a dual endothelin converting enzyme/neutral endopeptidase inhibitor on the development of pulmonary hypertension secondary to cardiac dysfunction in the rat.
Pediatric pulmonology 2010;45(11):1076-85.
2010: Hui-Hsuan Chung; Zen-Kong Dai; Bin-Nan Wu; Jwu-Lai Yeh; Chee-Yin Chai; Koung-Shing Chu; Chung-Pin Liu; Ing-Jun Chen
The xanthine derivative KMUP-1 inhibits models of pulmonary artery hypertension via increased NO and cGMP-dependent inhibition of RhoA/Rho kinase.
British journal of pharmacology 2010;160(4):971-86.
2010: Jwu-Lai Yeh; Jong-Hau Hsu; Ping-Ju Wu; Shu-Fen Liou; Chung-Pin Liu; Ing-Jun Chen; Bin-Nan Wu; Zen-Kong Dai; Jiunn-Ren Wu
KMUP-1 attenuates isoprenaline-induced cardiac hypertrophy in rats through NO/cGMP/PKG and ERK1/2/calcineurin A pathways.
British journal of pharmacology 2010;159(5):1151-60.
2009: Bin-Nan Wu; Mu-Long Chen; Zen-Kong Dai; Yi-Ling Lin; Jwu-Lai Yeh; Jiunn-Ren Wu; Ing-Jun Chen
Inhibition of voltage-gated L-type calcium channels by labedipinedilol-A involves protein kinase C in rat cerebrovascular smooth muscle cells.
Vascular pharmacology 2009;51(2-3):65-71.
2009: Shu-Fen Liou; Hung-Hong Lin; Jyh-Chong Liang; Ing-Jun Chen; Jwu-Lai Yeh
Inhibition of human prostate cancer cells proliferation by a selective alpha1-adrenoceptor antagonist labedipinedilol-A involves cell cycle arrest and apoptosis.
Toxicology 2009;256(1-2):13-24.
2009: Jiunn-Ren Wu; Shu-Fen Liou; Shin-Wha Lin; Chee-Yin Chai; Zen-Kong Dai; Jyh-Chong Liang; Ing-Jun Chen; Jwu-Lai Yeh
Lercanidipine inhibits vascular smooth muscle cell proliferation and neointimal formation via reducing intracellular reactive oxygen species and inactivating Ras-ERK1/2 signaling.
Pharmacological research : the official journal of the Italian Pharmacological Society 2009;59(1):48-56.
2008: Jwu-Lai Yeh; Shu-Fen Liou; Yu-Pay Chang; Shin-Wha Lin; Ts'an-Shiun Liu; Bin-Nan Wu; Ing-Jun Chen; Jiunn-Ren Wu
Isoeugenodilol inhibits smooth muscle cell proliferation and neointimal thickening after balloon injury via inactivation of ERK1/2 pathway.
Journal of biomedical science 2008;15(3):375-89.
2008: Bi-Fang Lee; Jwu-Lai Yeh; Nan-Tsing Chiu; Guocheng liu; Hsin-Su Yu; Mei-Hui Wang; Lie-Hang Shen
Evaluation of Tc-99m (V) DMSA binding to human plasma proteins.
The Kaohsiung journal of medical sciences 2008;24(1):1-9.
2007: Howard P Goodkin; Chengsan Sun; Jwu-Lai Yeh; Patrick S Mangan; Jaideep Kapur
GABA(A) receptor internalization during seizures.
Epilepsia 2007;48 Suppl 5():109-13.
2006: Bin-Nan Wu; Chien-Wen Chen; Shu-Fen Liou; Jwu-Lai Yeh; Hui-Hsuan Chung; Ing-Jun Chen
Inhibition of proinflammatory tumor necrosis factor-{alpha}-induced inducible nitric-oxide synthase by xanthine-based 7-[2-[4-(2-chlorobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine (KMUP-1) and 7-[2-[4-(4-nitrobenzene)piperazinyl]ethyl]-1, 3-dimethylxanthine (KMUP-3) in rat trachea: The involvement of soluble guanylate cyclase and protein kinase G.
Molecular pharmacology 2006;70(3):977-85.
2006: Jhy-Chong Liang; Hen-Rong Chen; Chaw-Chi Chiu; Shu-Fen Liou; Ing-Jun Chen; Jwu-Lai Yeh
Protective effect of labedipinedilol-A, a novel dihydropyridine-type calcium channel blocker, on myocardial apoptosis in ischemia-reperfusion injury.
Life sciences 2006;79(13):1248-56.
2006: Mian-Shin Tan; Chee-Yin Chai; Jiunn-Ren Wu; Jwu-Lai Yeh; Ing-Jun Chen; Aij-Lie Kwan; Arco Y Jeng; Huey-Yu Yang; Meng-Hsun Lee; Zen-Kong Dai
Differential change in expression of pulmonary ET-1 and eNOS in rats after chronic left ventricular pressure overload.
Experimental biology and medicine (Maywood, N.J.) 2006;231(6):948-53.
2006: Zen-Kong Dai; Mian-Shin Tan; Chee-Yin Chai; Shah-Hwa Chou; Pei-Chin Lin; Jwu-Lai Yeh; Arco Y Jeng; Chung-I Chang; Ing-Jun Chen; Jiunn-Ren Wu
Effects of sildenafil on pulmonary hypertension and levels of ET-1, eNOS, and cGMP in aorta-banded rats.
Experimental biology and medicine (Maywood, N.J.) 2006;231(6):942-7.
2005: Jwu-Lai Yeh; Jong-Hau Hsu; Zen-Kong Dai; Shu-Fen Liou; Ing-Jun Chen; Jiunn-Ren Wu
Increased circulating big endothelin-1, endothelin-1 and atrial natriuretic peptide in infants and children with heart failure secondary to congenital heart disease.
International journal of cardiology 2005;104(1):15-20.
2005: Jong-Hau Hsu; Jwu-Lai Yeh; Zen-Kong Dai; Ing-Jun Chen; Jiunn-Ren Wu
Increased circulating calcitonin gene-related peptide in congestive heart failure caused by congenital heart disease.
International heart journal 2005;46(5):867-75.
2005: Jwu-Lai Yeh; Shu-Fen Liou; Jhy-Chong Liang; Chih-Hsiung Lee; Chaw-Chi Chiu; Young-Tso Lin; Ing-Jun Chen
Labedipinedilol-C: a third-generation dihydropyridine-type calcium channel antagonist displaying K+ channel opening, NO-dependent and adrenergic antagonist activities.
Journal of cardiovascular pharmacology 2005;46(2):130-40.
2005: Howard P Goodkin; Jwu-Lai Yeh; Jaideep Kapur
Status epilepticus increases the intracellular accumulation of GABAA receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(23):5511-20.
2005: Shu-Fen Liou; Jiunn-Ren Wu; Wen-Ter Lai; Sheng-Hsiung Sheu; Ing-Jun Chen; Jwu-Lai Yeh
The vasorelaxing action of labedipinedilol-A involves endothelial cell-derived NO and eNOS expression caused by calcium influx.
Journal of cardiovascular pharmacology 2005;45(3):232-40.
2004: Shu-Fen Liou; Jwu-Lai Yeh; Jhy-Chong Liang; Chaw-Chi Chiu; Young-Tso Lin; Ing-Jun Chen
Inhibition of mitogen-mediated proliferation of rat vascular smooth muscle cells by labedipinedilol-A through PKC and ERK 1/2 pathway.
Journal of cardiovascular pharmacology 2004;44(5):539-51.
2004: Zen-Kong Dai; Mian-Shin Tan; Chee-Yin Chai; Jwu-Lai Yeh; Shah-Hwa Chou; Chaw-Chi Chiu; Arco Y Jeng; Ing-Jun Chen; Jiunn-Ren Wu
Upregulation of endothelial nitric oxide synthase and endothelin-1 in pulmonary hypertension secondary to heart failure in aorta-banded rats.
Pediatric pulmonology 2004;37(3):249-56.
2004: Chaw-Chi Chiu; Jiunn-Ren Wu; Chih-Hsiung Lee; Shu-Fen Liou; Zen-Kong Dai; Ing-Jun Chen; Jwu-Lai Yeh
Anti-hypertension effect of vanylidilol: a phenylaldehyde alpha/beta-adrenoceptor blocker with endothelium-dependent and K+ channels opening-associated vasorelaxant activities.
Pharmacology 2004;70(3):140-51.
2003: Yi-Ching Lo; Hui-Chuan Hsiao; deng-chyang wu; Rong-Jyh Lin; Jhy-Chong Liang; Jwu-Lai Yeh; Ing-Jun Chen
A novel capsaicin derivative VOA induced relaxation in rat mesenteric and aortic arteries: involvement of CGRP, NO, cGMP, and endothelium-dependent activities.
Journal of cardiovascular pharmacology 2003;42(4):511-20.
2003: Reen-Yen Kuo; Chin-Chung Wu; Fang-Rong Chang; Jwu-Lai Yeh; Ing-Jun Chen; Yang-Chang Wu
Antiplatelet activity of synthetic pyrrolo-benzylisoquinolines.
Bioorganic & medicinal chemistry letters 2003;13(5):821-3.
2002: Jwu-Lai Yeh; Jiunn-Ren Wu; Chaw-Chi Chiu; Yea-Wen Chen; Yi-Ching Lo; Young-Tso Lin; Chang-Jenq Cheng; Ing-Jun Chen
Vanillylamide-based propanolamine derivative displays alpha/beta-adrenoceptor blocking and vasodilating properties.
Journal of cardiovascular pharmacology 2002;39(6):803-13.
2002: Yu-Ying Chao; Ih-Sheng Chen; Jwu-Lai Yeh; Jih-Jung Chen; Ying-Chin Ko; Jin-Shiung Cheng; Chun-Peng Liu; Yuk-Keung Lo; Warren Su; Kang-Ju Chou; Wei-Chung Chen; Chung-Ren Jan
Novel action of lignans isolated from Hernandia nymphaeifolia on Ca(2+) signaling in renal tubular cells.
European journal of pharmacology 2002;443(1-3):31-8.
2002: Jhy-Chong Liang; Jwu-Lai Yeh; Chia-Sui Wang; Shu-Fen Liou; Chieh-Ho Tsai; Ing-Jun Chen
The new generation dihydropyridine type calcium blockers, bearing 4-phenyl oxypropanolamine, display alpha-/beta-adrenoceptor antagonist and long-acting antihypertensive activities.
Bioorganic & medicinal chemistry 2002;10(3):719-30.
2001: Y C Huang; Bin-Nan Wu; Jwu-Lai Yeh; S J Chen; Jhy-Chong Liang; Y C Lo; Ing-Jun Chen
A new aspect of view in synthesizing new type beta-adrenoceptor blockers with ancillary antioxidant activities.
Bioorganic & medicinal chemistry 2001;9(7):1739-46.
2000: Chaw-Chi Chiu; Young-Tso Lin; C H Tsai; Jhy-Chong Liang; Lien-Chai Chiang; Jiunn-Ren Wu; Ing-Jun Chen; Jwu-Lai Yeh
Pharmacological effects of an aldehyde type alpha/beta-adrenoceptor blocking agent with vasodilating properties.
General pharmacology 2000;34(6):391-400.
2000: Yu-Wen Chen; Jwu-Lai Yeh; Y C Huang; Ing-Jun Chen; Yin-Feng Huang; Guocheng liu
The interference of uptake of thallium-201 in cultured rat myocardial cells with existence of potassium related pharmaceuticals--a preliminary report.
The Kaohsiung journal of medical sciences 2000;16(3):134-40.
2000: Jwu-Lai Yeh; Shu-Fen Liou; Jhy-Chong Liang; Y C Huang; Lien-Chai Chiang; Jiunn-Ren Wu; Young-Tso Lin; Ing-Jun Chen
Vanidipinedilol: a vanilloid-based beta-adrenoceptor blocker displaying calcium entry blocking and vasorelaxant activities.
Journal of cardiovascular pharmacology 2000;35(1):51-63.
1999: Y C Yang; C R Ma; Jwu-Lai Yeh; Yi-Ching Lo; Bin-Nan Wu; Young-Tso Lin; Ing-Jun Chen
Nitrated nonivamide displaying a drawback of proton's role in capsaicin-associated sensory and neuronal activities.
General pharmacology 1999;33(3):257-69.
1998: Jwu-Lai Yeh; Jiunn-Ren Wu; C I Lin; Ing-Jun Chen
Ionic effects of capsinolol, a calcitonin gene-related peptide releasing beta-adrenoceptor blocker, on isolated cardiac muscles.
General pharmacology 1998;31(2):253-60.
1997: Ing-Jun Chen; Yi-Ching Lo; W J Lo; Jwu-Lai Yeh; Bin-Nan Wu
Capsazocaine: a capsaicin-sensitive functional antagonist displays an argument on sensory capsaicin receptor.
General pharmacology 1997;29(3):387-95.
1996: Ing-Jun Chen; Jwu-Lai Yeh; Yi-Ching Lo; S H Sheu; Young-Tso Lin
Capsinolol: the first beta-adrenoceptor blocker with an associated calcitonin gene-related peptide releasing activity in the heart.
British journal of pharmacology 1996;119(1):7-14.
1996: Jiunn-Ren Wu; Stephen A Fann; Jwu-Lai Yeh; Yi-Ching Lo; T Y Huang; Ing-Jun Chen
Multiple sensory and functional effects of non-phenolic aminodimethylene nonivamide: an approach to capsaicin antagonist.
General pharmacology 1996;27(1):151-8.
1995: S J Chen; Bin-Nan Wu; Jwu-Lai Yeh; Yi-Ching Lo; I S Chen; Ing-Jun Chen
C-fiber-evoked autonomic cardiovascular effects after injection of Piper betle inflorescence extracts.
Journal of ethnopharmacology 1995;45(3):183-8.
1994: Ing-Jun Chen; Jwu-Lai Yeh; S J Liou; A Y Shen
Guaiacoxypropanolamine derivatives of capsaicin: a new family of beta-adrenoceptor blockers with intrinsic cardiotonic properties.
Journal of medicinal chemistry 1994;37(7):938-43.
1994: Yi-Ching Lo; Jwu-Lai Yeh; Jiunn-Ren Wu; J M Yang; S J Chen; Ing-Jun Chen
Autonomic and sensory cardiovascular activities of nonivamide: intrathecal administration of clonidine.
Brain research bulletin 1994;35(1):15-22.
1993: Jwu-Lai Yeh; Yi-Ching Lo; Y Wang; Ing-Jun Chen
Cardiovascular interactions of nonivamide, glyceryl nonivamide, capsaicin analogues, and substance P antagonist in rats.
Brain research bulletin 1993;30(5-6):641-8.
1991: Ing-Jun Chen; Z I Liu; Jwu-Lai Yeh; Bin-Nan Wu
Vanidil: a newly synthesized antiangina nonvolatile organic solid nitrate.
Gaoxiong yi xue ke xue za zhi = The Kaohsiung journal of medical sciences 1991;7(9):476-80.
1991: Jwu-Lai Yeh; Ing-Jun Chen
Cardiovascular effects of nonivamide succinate.
Gaoxiong yi xue ke xue za zhi = The Kaohsiung journal of medical sciences 1991;7(4):173-82.
1990: Ing-Jun Chen; J M Yang; Jwu-Lai Yeh; Bin-Nan Wu; K P Hwang; C H Chiang
[Comparative study on the pharmacokinetics and bioequivalence of two brands of norfloxacin preparation].
Gaoxiong yi xue ke xue za zhi = The Kaohsiung journal of medical sciences 1990;6(9):501-10.