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Fadi Akar

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Electrophysiology

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Chaoqin Xie; Miguel A Aon; Nora Biary; Justin Kauffman; Nazareno Paolocci; Carlo G Tocchetti; Fadi G Akar
Glutathione oxidation unmasks proarrhythmic vulnerability of chronically hyperglycemic guinea pigs.
Rianne Nederlof; Richard Southworth; Alice Warley; Chaoqin Xie; Fadi G Akar; Otto Eerbeek; Markus W Hollmann; Anneke Koeman; Egbert G Mik; Dan M J Milstein; Coert J Zuurbier
Pathophysiological consequences of TAT-HKII peptide administration are independent of impaired vascular function and ensuing ischemia.
Carlo G Tocchetti; WALTER WATSON; Chaoqin Xie; Fadi G Akar; Viviane Caceres; Sonia Cortassa; Brian O'Rourke; Nazareno Paolocci; Sa Shi; Regina C Spadari-Bratfisch; Brian A Stanley; Miguel A Aon
GSH or palmitate preserves mitochondrial energetic/redox balance, preventing mechanical dysfunction in metabolically challenged myocytes/hearts from type 2 diabetic mice.

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All Publications

2013: Chaoqin Xie; Miguel A Aon; Nora Biary; Justin Kauffman; Nazareno Paolocci; Carlo G Tocchetti; Fadi G Akar
Glutathione oxidation unmasks proarrhythmic vulnerability of chronically hyperglycemic guinea pigs.
American journal of physiology. Heart and circulatory physiology 2013;304(7):H916-26.
2013: Rianne Nederlof; Richard Southworth; Alice Warley; Chaoqin Xie; Fadi G Akar; Otto Eerbeek; Markus W Hollmann; Anneke Koeman; Egbert G Mik; Dan M J Milstein; Coert J Zuurbier
Pathophysiological consequences of TAT-HKII peptide administration are independent of impaired vascular function and ensuing ischemia.
Circulation research 2013;112(2):e8-13.
2012: Carlo G Tocchetti; WALTER WATSON; Chaoqin Xie; Fadi G Akar; Viviane Caceres; Sonia Cortassa; Brian O'Rourke; Nazareno Paolocci; Sa Shi; Regina C Spadari-Bratfisch; Brian A Stanley; Miguel A Aon
GSH or palmitate preserves mitochondrial energetic/redox balance, preventing mechanical dysfunction in metabolically challenged myocytes/hearts from type 2 diabetic mice.
Diabetes 2012;61(12):3094-105.
2012: Caline S Karam; Fadi G Akar
Genetic silencing of pacemaker cells: local intervention with global implications.
Journal of the American Heart Association 2012;1(2):e001412.
2011: Nora Biary; Justin Kauffman; Chaoqin Xie; Fadi G Akar
Biophysical properties and functional consequences of reactive oxygen species (ROS)-induced ROS release in intact myocardium.
The Journal of physiology 2011;589(Pt 21):5167-79.
2011: Fadi G Akar; Brian O'Rourke
Mitochondria are sources of metabolic sink and arrhythmias.
Pharmacology & therapeutics 2011;131(3):287-94.
2011: Kirsten M A Smeele; Richard Southworth; Rongxue Wu; Chaoqin Xie; Rianne Nederlof; Alice Warley; Jessica K Nelson; Pepijn van Horssen; Jeroen van den Wijngaard; Sami Heikkinen; Markku Laakso; Anneke Koeman; Maria Siebes; Otto Eerbeek; Fadi G Akar; Hossein Ardehali; Markus W Hollmann; Coert J Zuurbier
Disruption of hexokinase II-mitochondrial binding blocks ischemic preconditioning and causes rapid cardiac necrosis.
Circulation research 2011;108(10):1165-9.
2010: Roger J Hajjar; Fadi G Akar
Regression of cardiac hypertrophy by cyclic guanosine monophosphate-dependent protein kinase signaling are myocytes active sources or mere beneficiaries?
Journal of the American College of Cardiology 2010;56(24):2031-2.
2010: Alexander R Lyon; Paul J Joudrey; Dongzhu Jin; Robert D Nass; Miguel A Aon; Brian O'Rourke; Fadi G Akar
Optical imaging of mitochondrial function uncovers actively propagating waves of mitochondrial membrane potential collapse across intact heart.
Journal of molecular and cellular cardiology 2010;49(4):565-75.
2010: Nora Biary; Fadi G Akar
A brighter side of ROS revealed by selective activation of beta-adrenergic receptor subtypes.
The Journal of physiology 2010;588(Pt 16):2973-4.
2010: Fadi G Akar
Use-dependent modulation of myocardial conduction by a new class of HERG agonists: deal breaker or cherry on top?
Journal of cardiovascular electrophysiology 2010;21(8):930-2.
2010: Chi-Wing Kong; Fadi G Akar; Ronald A Li
Translational potential of human embryonic and induced pluripotent stem cells for myocardial repair: insights from experimental models.
Thrombosis and haemostasis 2010;104(1):30-8.
2010: Hongwei Jin; Robert D Nass; Paul J Joudrey; Alexander R Lyon; Elie R Chemaly; Kleopatra Rapti; Fadi G Akar
Altered spatiotemporal dynamics of the mitochondrial membrane potential in the hypertrophied heart.
Biophysical journal 2010;98(10):2063-71.
2010: Geoffrey G Hesketh; Manish Shah; Victoria L Halperin; CA Cooke; Fadi G Akar; Timothy E Yen; David A Kass; Carolyn E Machamer; Jennifer E Van Eyk; Gordon F Tomaselli
Ultrastructure and regulation of lateralized connexin43 in the failing heart.
Circulation research 2010;106(6):1153-63.
2010: Fadi G Akar
Left ventricular repolarization heterogeneity as an arrhythmic substrate in heart failure.
Minerva cardioangiologica 2010;58(2):205-12.
2010: Hongwei Jin; Elie R Chemaly; Ahyoung Lee; Changwon Kho; Lahouaria Hadri; Roger J Hajjar; Fadi G Akar
Mechanoelectrical remodeling and arrhythmias during progression of hypertrophy.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(2):451-63.
2010: Takeshi Aiba; Geoffrey G Hesketh; Ting Liu; Rachael Carlisle; Maria Celeste Villa-Abrille; Brian O'Rourke; Fadi G Akar; Gordon F Tomaselli
Na+ channel regulation by Ca2+/calmodulin and Ca2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes.
Cardiovascular research 2010;85(3):454-63.
2010: Chaoqin Xie; Fadi G Akar
Mitochondrial dysfunction: a new frontier in the search for elusive arrhythmia mechanisms.
Frontiers in physiology 2010;1():163.
2009: Miguel A Aon; Sonia Cortassa; Fadi G Akar; David A Brown; L Zhou; Brian O'Rourke
From mitochondrial dynamics to arrhythmias.
The international journal of biochemistry & cell biology 2009;41(10):1940-8.
2009: Takeshi Aiba; Geoffrey G Hesketh; Andreas S Barth; Ting Liu; Samantapudi Daya; Khalid Chakir; Veronica Lea Dimaano; Theodore P Abraham; Brian O'Rourke; Fadi G Akar; David A Kass; Gordon F Tomaselli
Electrophysiological consequences of dyssynchronous heart failure and its restoration by resynchronization therapy.
Circulation 2009;119(9):1220-30.
2008: Zhong Gao; Andreas S Barth; Deborah DiSilvestre; Fadi G Akar; Yanli Tian; Antti Tanskanen; David A Kass; Raimond L Winslow; Gordon F Tomaselli
Key pathways associated with heart failure development revealed by gene networks correlated with cardiac remodeling.
Physiological genomics 2008;35(3):222-30.
2008: Torsten K Roepke; Andrianos Kontogeorgis; Christopher Ovanez; Xianghua Xu; Jeffrey B Young; Kerry Purtell; Peter A Goldstein; David J Christini; Nicholas S Peters; Fadi G Akar; David E Gutstein; Daniel J Lerner; Geoffrey W Abbott
Targeted deletion of kcne2 impairs ventricular repolarization via disruption of I(K,slow1) and I(to,f).
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(10):3648-60.
2008: Hongwei Jin; Alexander R Lyon; Fadi G Akar
Arrhythmia mechanisms in the failing heart.
Pacing and clinical electrophysiology : PACE 2008;31(8):1048-56.
2008: David A Brown; Miguel A Aon; Fadi G Akar; Ting Liu; Nicolas Sorarrain; Brian O'Rourke
Effects of 4'-chlorodiazepam on cellular excitation-contraction coupling and ischaemia-reperfusion injury in rabbit heart.
Cardiovascular research 2008;79(1):141-9.
2008: Rachele Lipsky; Essie M Potts; Sima T Tarzami; Akil A Puckerin; Joanne Stocks; Alison D Schecter; Eric Sobie; Fadi G Akar; María A Diversé-Pierluissi
beta-Adrenergic receptor activation induces internalization of cardiac Cav1.2 channel complexes through a beta-arrestin 1-mediated pathway.
The Journal of biological chemistry 2008;283(25):17221-6.
2008: Robert D Nass; Takeshi Aiba; Gordon F Tomaselli; Fadi G Akar
Mechanisms of disease: ion channel remodeling in the failing ventricle.
Nature clinical practice. Cardiovascular medicine 2008;5(4):196-207.
2007: Fadi G Akar
The perfect storm: defective calcium cycling in insulated fibers with reduced repolarization reserve.
Circulation research 2007;101(10):968-70.
2007: Joseph G Akar; Fadi G Akar
Regulation of ion channels and arrhythmias in the ischemic heart.
Journal of electrocardiology 2007;40(6 Suppl):S37-41.
2007: Fadi G Akar; Robert D Nass; Samuel Hahn; Eugenio Cingolani; Manish Shah; Geoffrey G Hesketh; Deborah DiSilvestre; Richard S Tunin; David A Kass; Gordon F Tomaselli
Dynamic changes in conduction velocity and gap junction properties during development of pacing-induced heart failure.
American journal of physiology. Heart and circulatory physiology 2007;293(2):H1223-30.
2007: Brian O'Rourke; Sonia Cortassa; Fadi G Akar; Miguel A Aon
Mitochondrial ion channels in cardiac function and dysfunction.
Novartis Foundation symposium 2007;287():140-51; discussion 152-6.
2006: Joseph G Akar; Fadi G Akar
Mapping arrhythmias in the failing heart: from Langendorff to patient.
Journal of electrocardiology 2006;39(4 Suppl):S19-23.
2006: Hung-Fat Tse; Tian Xue; Chu-Pak Lau; Chung Wah SIU; Kai Wang; Qing-Yong Zhang; Gordon F Tomaselli; Fadi G Akar; Ronald A Li
Bioartificial sinus node constructed via in vivo gene transfer of an engineered pacemaker HCN Channel reduces the dependence on electronic pacemaker in a sick-sinus syndrome model.
Circulation 2006;114(10):1000-11.
2006: Miguel A Aon; Sonia Cortassa; Fadi G Akar; Brian O'Rourke
Mitochondrial criticality: a new concept at the turning point of life or death.
Biochimica et biophysica acta 2006;1762(2):232-40.
2005: Fadi G Akar; Miguel A Aon; Gordon F Tomaselli; Brian O'Rourke
The mitochondrial origin of postischemic arrhythmias.
The Journal of clinical investigation 2005;115(12):3527-35.
2005: Manish Shah; Fadi G Akar; Gordon F Tomaselli
Molecular basis of arrhythmias.
Circulation 2005;112(16):2517-29.
2005: Fadi G Akar; Gordon F Tomaselli
Conduction abnormalities in nonischemic dilated cardiomyopathy: basic mechanisms and arrhythmic consequences.
Trends in cardiovascular medicine 2005;15(7):259-64.
2005: David Spragg; Fadi G Akar; Robert H Helm; Richard S Tunin; Gordon F Tomaselli; David A Kass
Abnormal conduction and repolarization in late-activated myocardium of dyssynchronously contracting hearts.
Cardiovascular research 2005;67(1):77-86.
2005: Fadi G Akar; Richard C Wu; George J Juang; Yanli Tian; Mirka Burysek; Deborah DiSilvestre; Wei Xiong; Antonis A Armoundas; Gordon F Tomaselli
Molecular mechanisms underlying K+ current downregulation in canine tachycardia-induced heart failure.
American journal of physiology. Heart and circulatory physiology 2005;288(6):H2887-96.
2005: Tian Xue; Hee Cheol Cho; Fadi G Akar; Suk Ying Tsang; Steven P Jones; Eduardo Marban; Gordon F Tomaselli; Ronald A Li
Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: insights into the development of cell-based pacemakers.
Circulation 2005;111(1):11-20.
2005: Fadi G Akar; Gordon F Tomaselli
Ion channels as novel therapeutic targets in heart failure.
Annals of medicine 2005;37(1):44-54.
2004: Fadi G Akar; David Spragg; Richard S Tunin; David A Kass; Gordon F Tomaselli
Mechanisms underlying conduction slowing and arrhythmogenesis in nonischemic dilated cardiomyopathy.
Circulation research 2004;95(7):717-25.
2004: Steven Poelzing; Fadi G Akar; Elvera Baron; David S Rosenbaum
Heterogeneous connexin43 expression produces electrophysiological heterogeneities across ventricular wall.
American journal of physiology. Heart and circulatory physiology 2004;286(5):H2001-9.
2004: Fadi G Akar; Richard C Wu; Isabelle Deschenes; Antonis A Armoundas; Valentino Piacentino; Steven R Houser; Gordon F Tomaselli
Phenotypic differences in transient outward K+ current of human and canine ventricular myocytes: insights into molecular composition of ventricular Ito.
American journal of physiology. Heart and circulatory physiology 2004;286(2):H602-9.
2003: Fadi G Akar; David S Rosenbaum
Transmural electrophysiological heterogeneities underlying arrhythmogenesis in heart failure.
Circulation research 2003;93(7):638-45.
2002: Fadi G Akar; Gan-Xin Yan; Charles Antzelevitch; David S Rosenbaum
Unique topographical distribution of M cells underlies reentrant mechanism of torsade de pointes in the long-QT syndrome.
Circulation 2002;105(10):1247-53.
2001: Fadi G Akar; B J Roth; David S Rosenbaum
Optical measurement of cell-to-cell coupling in intact heart using subthreshold electrical stimulation.
American journal of physiology. Heart and circulatory physiology 2001;281(2):H533-42.
2000: Fadi G Akar; Kenneth R Laurita; David S Rosenbaum
Cellular basis for dispersion of repolarization underlying reentrant arrhythmias.
Journal of electrocardiology 2000;33 Suppl():23-31.
1999: Joseph M Pastore; SD Girouard; Kenneth R Laurita; Fadi G Akar; David S Rosenbaum
Mechanism linking T-wave alternans to the genesis of cardiac fibrillation.
Circulation 1999;99(10):1385-94.
1998: Kenneth R Laurita; SD Girouard; Fadi G Akar; David S Rosenbaum
Modulated dispersion explains changes in arrhythmia vulnerability during premature stimulation of the heart.
Circulation 1998;98(24):2774-80.