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Tim Yen

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TOP 3
Haomin Huang; Tim J Yen
BubR1 is an effector of multiple mitotic kinases that specifies kinetochore: microtubule attachments and checkpoint.
Neil Beeharry; Tim J Yen
p53-dependent apoptosis in response to spindle damage is linked to loss of Bub1.
Haomin Huang; James Hittle; Francesca Zappacosta; Roland S Annan; Avram Hershko; Tim J Yen
Phosphorylation sites in BubR1 that regulate kinetochore attachment, tension, and mitotic exit.

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All Publications

2009: Haomin Huang; Tim J Yen
BubR1 is an effector of multiple mitotic kinases that specifies kinetochore: microtubule attachments and checkpoint.
Cell cycle (Georgetown, Tex.) 2009;8(8):1164-7.
2009: Neil Beeharry; Tim J Yen
p53-dependent apoptosis in response to spindle damage is linked to loss of Bub1.
Cancer biology & therapy 2009;8(7):645-7.
2008: Haomin Huang; James Hittle; Francesca Zappacosta; Roland S Annan; Avram Hershko; Tim J Yen
Phosphorylation sites in BubR1 that regulate kinetochore attachment, tension, and mitotic exit.
The Journal of cell biology 2008;183(4):667-80.
2007: Elizabeth M Matthew; Tim J Yen; David T Dicker; Jay F Dorsey; Wensheng Yang; Arunasalam Navaraj; Wafik S El-Deiry
Replication stress, defective S-phase checkpoint and increased death in Plk2-deficient human cancer cells.
Cell cycle (Georgetown, Tex.) 2007;6(20):2571-8.
2007: Haomin Huang; Jie Feng; Jakub K Famulski; Jerome B Rattner; Song-Tao Liu; Gary D Kao; Ruth J Muschel; Gordon K T Chan; Tim J Yen
Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments.
The Journal of cell biology 2007;177(3):413-24.
2007: Rugang Zhang; Song-Tao Liu; Wei Chen; Michael Bonner; John Pehrson; Tim J Yen; Paul D Adams
HP1 proteins are essential for a dynamic nuclear response that rescues the function of perturbed heterochromatin in primary human cells.
Molecular and cellular biology 2007;27(3):949-62.
2007: Tim J Yen
Polo delivers a PICH to the kinetochore.
Cell 2007;128(1):20-1.
2007: Valery Sudakin; Tim J Yen
Targeting mitosis for anti-cancer therapy.
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 2007;21(4):225-33.
2006: Song-Tao Liu; Jerome B Rattner; Sandra A Jablonski; Tim J Yen
Mapping the assembly pathways that specify formation of the trilaminar kinetochore plates in human cells.
The Journal of cell biology 2006;175(1):41-53.
2006: J Feng; H Huang; Tim J Yen
CENP-F is a novel microtubule-binding protein that is essential for kinetochore attachments and affects the duration of the mitotic checkpoint delay.
Chromosoma 2006;115(4):320-9.
2005: Gordon K T Chan; Song-Tao Liu; Tim J Yen
Kinetochore structure and function.
Trends in cell biology 2005;15(11):589-98.
2005: April R Robbins; Sandra A Jablonski; Tim J Yen; Kinya Yoda; Rob Robey; Susan E Bates; Dan L Sackett
Inhibitors of histone deacetylases alter kinetochore assembly by disrupting pericentromeric heterochromatin.
Cell cycle (Georgetown, Tex.) 2005;4(5):717-26.
2005: Cristiana Mollinari; Jean-Philippe Kleman; Yasmina Saoudi; Sandra A Jablonski; Julien Perard; Tim J Yen; Robert L Margolis
Ablation of PRC1 by small interfering RNA demonstrates that cytokinetic abscission requires a central spindle bundle in mammalian cells, whereas completion of furrowing does not.
Molecular biology of the cell 2005;16(3):1043-55.
2005: Tim J Yen; Gary D Kao
Mitotic checkpoint, aneuploidy and cancer.
Advances in experimental medicine and biology 2005;570():477-99.
2004: Nicholas Bertos; Benoit Gilquin; Gordon K T Chan; Tim J Yen; Saadi Khochbin; Xiang-Jiao Yang
Role of the tetradecapeptide repeat domain of human histone deacetylase 6 in cytoplasmic retention.
The Journal of biological chemistry 2004;279(46):48246-54.
2004: Jomon Joseph; Song-Tao Liu; Sandra A Jablonski; Tim J Yen; Mary Dasso
The RanGAP1-RanBP2 complex is essential for microtubule-kinetochore interactions in vivo.
Current biology : CB 2004;14(7):611-7.
2004: Valery Sudakin; Tim J Yen
Purification of the mitotic checkpoint complex, an inhibitor of the APC/C from HeLa cells.
Methods in molecular biology (Clifton, N.J.) 2004;281():199-212.
2003: Sandra A Jablonski; Song-Tao Liu; Tim J Yen
Targeting the kinetochore for mitosis-specific inhibitors.
Cancer biology & therapy 2003;2(3):236-41.
2003: Lynda Fletcher; Tim J Yen; Ruth J Muschel
DNA damage in HeLa cells induced arrest at a discrete point in G2 phase as defined by CENP-F localization.
Radiation research 2003;159(5):604-11.
2003: René Daniel; Gary Kao; Konstantin D Taganov; James G Greger; Olga Favorova; George Merkel; Tim J Yen; Richard Katz; Anna Marie Skalka
Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(8):4778-83.
2003: Song-Tao Liu; Gordon K T Chan; James C Hittle; Gregory Fujii; Emma Lees; Tim J Yen
Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores.
Molecular biology of the cell 2003;14(4):1638-51.
2003: Byron Williams; Zexiao Li; Songtao Liu; Erika V Williams; Garmay Leung; Tim J Yen; Michael L Goldberg
Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions.
Molecular biology of the cell 2003;14(4):1379-91.
2003: Song-Tao Liu; James C Hittle; Sandra A Jablonski; Michael S Campbell; Kinya Yoda; Tim J Yen
Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis.
Nature cell biology 2003;5(4):341-5.
2003: Gary D Kao; W Gillies McKenna; Matthew G Guenther; Ruth J Muschel; Mitchell Lazar; Tim J Yen
Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response.
The Journal of cell biology 2003;160(7):1017-27.
2003: Song-Tao Liu; Jan M A van Deursen; Tim J Yen
The role of mitotic checkpoint in maintaining genomic stability.
Current topics in developmental biology 2003;58():27-51.
2003: Gordon K T Chan; Tim J Yen
The mitotic checkpoint: a signaling pathway that allows a single unattached kinetochore to inhibit mitotic exit.
Progress in cell cycle research 2003;5():431-9.
2002: Matthew G Guenther; Jiujiu Yu; Gary D Kao; Tim J Yen; Mitchell Lazar
Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex.
Genes & development 2002;16(24):3130-5.
2002: David M Nelson; Xiaofen Ye; Caitlin Hall; Hidelita Santos; Tianlin Ma; Gary D Kao; Tim J Yen; J Wade Harper; Paul D Adams
Coupling of DNA synthesis and histone synthesis in S phase independent of cyclin/cdk2 activity.
Molecular and cellular biology 2002;22(21):7459-72.
2002: Tim J Yen
The complexity of APC/C regulation: location, location, location.
Cell cycle (Georgetown, Tex.) 2002;1(4):260-1.
2002: Priya Chaturvedi; Valery Sudakin; Matthew L Bobiak; Paul W Fisher; Michael R Mattern; Sandra A Jablonski; Mark R Hurle; Yuan Zhu; Tim J Yen; Bin-Bing S Zhou
Chfr regulates a mitotic stress pathway through its RING-finger domain with ubiquitin ligase activity.
Cancer research 2002;62(6):1797-801.
2001: Aaron A Van Hooser; Ilia Ouspenski; Heather Gregson; Daniel A Starr; Tim J Yen; Michael L Goldberg; Kyoko Yokomori; William C Earnshaw; Kevin Sullivan; Bill R Brinkley
Specification of kinetochore-forming chromatin by the histone H3 variant CENP-A.
Journal of cell science 2001;114(Pt 19):3529-42.
2001: Valery Sudakin; Gordon K T Chan; Tim J Yen
Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2.
The Journal of cell biology 2001;154(5):925-36.
2001: B F McEwen; Gordon K T Chan; B Zubrowski; M S Savoian; M T Sauer; Tim J Yen
CENP-E is essential for reliable bioriented spindle attachment, but chromosome alignment can be achieved via redundant mechanisms in mammalian cells.
Molecular biology of the cell 2001;12(9):2776-89.
2001: X Wang; J Ramesh Babu; J M Harden; Sandra A Jablonski; M H Gazi; Wilma L Lingle; Piet C de Groen; Tim J Yen; Jan M A van Deursen
The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteins.
The Journal of biological chemistry 2001;276(28):26559-67.
2001: Gary D Kao; W Gillies McKenna; Tim J Yen
Detection of repair activity during the DNA damage-induced G2 delay in human cancer cells.
Oncogene 2001;20(27):3486-96.
2001: M S Campbell; Gordon K T Chan; Tim J Yen
Mitotic checkpoint proteins HsMAD1 and HsMAD2 are associated with nuclear pore complexes in interphase.
Journal of cell science 2001;114(Pt 5):953-63.
2001: René Daniel; Richard Katz; George Merkel; James C Hittle; Tim J Yen; Anna Marie Skalka
Wortmannin potentiates integrase-mediated killing of lymphocytes and reduces the efficiency of stable transduction by retroviruses.
Molecular and cellular biology 2001;21(4):1164-72.
2001: L Y Marmorstein; A V Kinev; Gordon K T Chan; Daniel Bochar; H Beniya; J A Epstein; Tim J Yen; Ramin Shiekhattar
A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression.
Cell 2001;104(2):247-57.
2000: Gordon K T Chan; Sandra A Jablonski; Daniel A Starr; Michael L Goldberg; Tim J Yen
Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores.
Nature cell biology 2000;2(12):944-7.
2000: Daniel A Starr; Richard Saffery; Zexiao Li; A E Simpson; K H Andy Choo; Tim J Yen; Michael L Goldberg
HZwint-1, a novel human kinetochore component that interacts with HZW10.
Journal of cell science 2000;113 ( Pt 11)():1939-50.
1999: Gordon K T Chan; Sandra A Jablonski; Valery Sudakin; James C Hittle; Tim J Yen
Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC.
The Journal of cell biology 1999;146(5):941-54.
1999: Frank Kullmann; Martin Judex; W Ballhorn; HP Jüsten; D Wessinghage; J Welsh; Tim J Yen; B Lang; James C Hittle; Michael McClelland; Steffen Gay; Jurgen Schölmerich; Ulf Müller-Ladner
Kinesin-like protein CENP-E is upregulated in rheumatoid synovial fibroblasts.
Arthritis research 1999;1(1):71-80.
1998: Sandra A Jablonski; Gordon K T Chan; CA Cooke; William C Earnshaw; Tim J Yen
The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis.
Chromosoma 1998;107(6-7):386-96.
1998: J Basu; Elsa Logarinho; S Herrmann; Hassan Bousbaa; Zexiao Li; Gordon K T Chan; Tim J Yen; Claudio Sunkel; Michael L Goldberg
Localization of the Drosophila checkpoint control protein Bub3 to the kinetochore requires Bub1 but not Zw10 or Rod.
Chromosoma 1998;107(6-7):376-85.
1998: Gordon K T Chan; BT Schaar; Tim J Yen
Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1.
The Journal of cell biology 1998;143(1):49-63.
1998: Maja Zecevic; Andrew D Catling; Scott T. Eblen; L Renzi; James C Hittle; Tim J Yen; Gary J Gorbsky; Michael J Weber
Active MAP kinase in mitosis: localization at kinetochores and association with the motor protein CENP-E.
The Journal of cell biology 1998;142(6):1547-58.
1998: D P Gately; James C Hittle; Gordon K T Chan; Tim J Yen
Characterization of ATM expression, localization, and associated DNA-dependent protein kinase activity.
Molecular biology of the cell 1998;9(9):2361-74.
1998: SC Liu; Edward R Sauter; Margie L Clapper; R S Feldman; L Levin; S Y Chen; Tim J Yen; Eric A Ross; Paul F Engstrom; Andres J P Klein-Szanto
Markers of cell proliferation in normal epithelia and dysplastic leukoplakias of the oral cavity.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1998;7(7):597-603.
1997: BT Schaar; Gordon K T Chan; P Maddox; E D Salmon; Tim J Yen
CENP-E function at kinetochores is essential for chromosome alignment.
The Journal of cell biology 1997;139(6):1373-82.
1997: CA Cooke; BT Schaar; Tim J Yen; William C Earnshaw
Localization of CENP-E in the fibrous corona and outer plate of mammalian kinetochores from prometaphase through anaphase.
Chromosoma 1997;106(7):446-55.
1996: Tim J Yen; B T Schaar
Kinetochore function: molecular motors, switches and gates.
Current opinion in cell biology 1996;8(3):381-8.
1995: H Liao; Robert J Winkfein; G Mack; Jerome B Rattner; Tim J Yen
CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis.
The Journal of cell biology 1995;130(3):507-18.
1995: D A Thrower; Mary Ann Jordan; B T Schaar; Tim J Yen; Leslie Wilson
Mitotic HeLa cells contain a CENP-E-associated minus end-directed microtubule motor.
The EMBO journal 1995;14(5):918-26.
1994: Joseph R Testa; J Y Zhou; DW Bell; Tim J Yen
Chromosomal localization of the genes encoding the kinetochore proteins CENPE and CENPF to human chromosomes 4q24-->q25 and 1q32-->q41, respectively, by fluorescence in situ hybridization.
Genomics 1994;23(3):691-3.
1994: H Liao; G Li; Tim J Yen
Mitotic regulation of microtubule cross-linking activity of CENP-E kinetochore protein.
Science (New York, N.Y.) 1994;265(5170):394-8.
1993: Jerome B Rattner; A Rao; Marvin Fritzler; D W Valencia; Tim J Yen
CENP-F is a .ca 400 kDa kinetochore protein that exhibits a cell-cycle dependent localization.
Cell motility and the cytoskeleton 1993;26(3):214-26.
1992: Tim J Yen; G Li; B T Schaar; I Szilak; D W Cleveland
CENP-E is a putative kinetochore motor that accumulates just before mitosis.
Nature 1992;359(6395):536-9.