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Linda Bristow

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Fraser Murray; Neil J Harrison; Sarah Grimwood; Linda J Bristow; Peter H Hutson
Nucleus accumbens NMDA receptor subunit expression and function is enhanced in morphine-dependent rats.
John R Atack; Keith A Wafford; Spencer J Tye; Susan M Cook; Bindi Sohal; Andrew Pike; Cyrille Sur; David Melillo; Linda J Bristow; Frances A Bromidge; Ian Ragan; Julie Kerby; Leslie J Street; Robert W Carling; José L Castro; Paul Whiting; Gerard R Dawson; Ruth M McKernan
TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates.
Martin R Guscott; Linda J Bristow; Karen L Hadingham; Thomas W Rosahl; Margaret S Beer; Josephine A Stanton; Frances A Bromidge; Andrew P Owens; Ian T Huscroft; Janice Myers; Nadia M J Rupniak; Smita Patel; Paul J Whiting; Peter H Hutson; Kevin C F Fone; S M Biello; Janusz J Kulagowski; George McAllister
Genetic knockout and pharmacological blockade studies of the 5-HT7 receptor suggest therapeutic potential in depression.

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All Publications

2007: Fraser Murray; Neil J Harrison; Sarah Grimwood; Linda J Bristow; Peter H Hutson
Nucleus accumbens NMDA receptor subunit expression and function is enhanced in morphine-dependent rats.
European journal of pharmacology 2007;562(3):191-7.
2006: John R Atack; Keith A Wafford; Spencer J Tye; Susan M Cook; Bindi Sohal; Andrew Pike; Cyrille Sur; David Melillo; Linda J Bristow; Frances A Bromidge; Ian Ragan; Julie Kerby; Leslie J Street; Robert W Carling; José L Castro; Paul Whiting; Gerard R Dawson; Ruth M McKernan
TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates.
The Journal of pharmacology and experimental therapeutics 2006;316(1):410-22.
2005: Martin R Guscott; Linda J Bristow; Karen L Hadingham; Thomas W Rosahl; Margaret S Beer; Josephine A Stanton; Frances A Bromidge; Andrew P Owens; Ian T Huscroft; Janice Myers; Nadia M J Rupniak; Smita Patel; Paul J Whiting; Peter H Hutson; Kevin C F Fone; S M Biello; Janusz J Kulagowski; George McAllister
Genetic knockout and pharmacological blockade studies of the 5-HT7 receptor suggest therapeutic potential in depression.
Neuropharmacology 2005;48(4):492-502.
2003: Martin R Guscott; Hannah F Clarke; Fraser Murray; Sarah Grimwood; Linda J Bristow; Peter H Hutson
The effect of (+/-)-CP-101,606, an NMDA receptor NR2B subunit selective antagonist, in the Morris watermaze.
European journal of pharmacology 2003;476(3):193-9.
2002: S Barak Caine; S Stevens Negus; Nancy K Mello; Smita Patel; Linda J Bristow; Janusz Kulagowski; Daniela Vallone; Adolfo Saiardi; Emiliana Borrelli
Role of dopamine D2-like receptors in cocaine self-administration: studies with D2 receptor mutant mice and novel D2 receptor antagonists.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(7):2977-88.
2002: Stephen R Fletcher; Frank Burkamp; Peter Blurton; Susan K F Cheng; Robert Clarkson; desmond oconnor; Daniel Spinks; Matthew Tudge; Monique B van Niel; Smita Patel; Kerry Chapman; Rose Marwood; Sara Shepheard; Graham Bentley; Gina P Cook; Linda J Bristow; José L Castro; Peter H Hutson; Angus M MacLeod
4-(Phenylsulfonyl)piperidines: novel, selective, and bioavailable 5-HT(2A) receptor antagonists.
Journal of medicinal chemistry 2002;45(2):492-503.
2001: Michael G N Russell; R J Baker; L Barden; Margaret S Beer; Linda J Bristow; Howard B Broughton; M Knowles; George McAllister; Smita Patel; José L Castro
N-Arylsulfonylindole derivatives as serotonin 5-HT(6) receptor ligands.
Journal of medicinal chemistry 2001;44(23):3881-95.
2001: Michael Rowley; Linda J Bristow; Peter H Hutson
Current and novel approaches to the drug treatment of schizophrenia.
Journal of medicinal chemistry 2001;44(4):477-501.
2000: Martin R Guscott; Gina P Cook; Linda J Bristow
Contextual fear conditioning and baseline startle responses in the rat fear-potentiated startle test: a comparison of benzodiazepine/gamma-aminobutyric acid-A receptor agonists.
Behavioural pharmacology 2000;11(6):495-504.
2000: Peter H Hutson; Cheryl L Barton; Mark T Jay; Peter Blurton; Frank Burkamp; Robert Clarkson; Linda J Bristow
Activation of mesolimbic dopamine function by phencyclidine is enhanced by 5-HT(2C/2B) receptor antagonists: neurochemical and behavioural studies.
Neuropharmacology 2000;39(12):2318-28.
2000: Ruth M McKernan; Thomas W Rosahl; David S Reynolds; Cyrille Sur; Keith A Wafford; John R Atack; SJ Farrar; Janice Myers; G Cook; Pushpinder Ferris; L Garrett; Linda J Bristow; George Marshall; Alison Macaulay; Nicola Brown; Owain Howell; Kevin W Moore; Robert W Carling; Leslie J Street; José L Castro; C I Ragan; Gerard R Dawson; Paul J Whiting
Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.
Nature neuroscience 2000;3(6):587-92.
2000: Linda J Bristow; desmond oconnor; R Watts; M S Duxon; Peter H Hutson
Evidence for accelerated desensitisation of 5-HT(2C) receptors following combined treatment with fluoxetine and the 5-HT(1A) receptor antagonist, WAY 100,635, in the rat.
Neuropharmacology 2000;39(7):1222-36.
1999: Sarah Harper; James Bilsland; L Young; Linda J Bristow; Susan Boyce; Glenn Mason; Michael Rigby; Louise Hewson; David Smith; Ruth O'Donnell; desmond oconnor; Raymond G Hill; D Evans; Christopher J Swain; B Williams; Franz Hefti
Analysis of the neurotrophic effects of GPI-1046 on neuron survival and regeneration in culture and in vivo.
Neuroscience 1999;88(1):257-67.
1998: Linda J Bristow; Gina P Cook; Smita Patel; Neil R Curtis; I Mawer; Janusz J Kulagowski
Discriminative stimulus properties of the putative dopamine D3 receptor agonist, (+)-PD 128907: role of presynaptic dopamine D2 autoreceptors.
Neuropharmacology 1998;37(6):793-802.
1997: Linda J Bristow; Neil Collinson; Gina P Cook; Neil R Curtis; SB Freedman; Janusz J Kulagowski; Paul D Leeson; Smita Patel; C Ian Ragan; Mark P Ridgill; KL Saywell; mark david tricklebank
L-745,870, a subtype selective dopamine D4 receptor antagonist, does not exhibit a neuroleptic-like profile in rodent behavioral tests.
The Journal of pharmacology and experimental therapeutics 1997;283(3):1256-63.
1997: Smita Patel; S Freedman; Kerry L Chapman; F Emms; AE Fletcher; M Knowles; Rose Marwood; George McAllister; Janice Myers; Neil R Curtis; Janusz J Kulagowski; Paul D Leeson; Mark P Ridgill; M Graham; S Matheson; D Rathbone; Alan P Watt; Linda J Bristow; Nadia M J Rupniak; E Baskin; Joseph J Lynch; C Ian Ragan
Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor.
The Journal of pharmacology and experimental therapeutics 1997;283(2):636-47.
1997: Linda J Bristow; M S Kramer; Janusz J Kulagowski; Smita Patel; C Ian Ragan; G R Seabrook
Schizophrenia and L-745,870, a novel dopamine D4 receptor antagonist.
Trends in pharmacological sciences 1997;18(6):186-8.
1997: Linda J Bristow; J E Hogg; Peter H Hutson
Competitive and glycine/NMDA receptor antagonists attenuate withdrawal-induced behaviours and increased hippocampal acetylcholine efflux in morphine-dependent rats.
Neuropharmacology 1997;36(2):241-50.
1996: BJ Bowery; Zerin Razzaque; F Emms; Smita Patel; S Freedman; Linda J Bristow; Janusz J Kulagowski; Guy R Seabrook
Antagonism of the effects of (+)-PD 128907 on midbrain dopamine neurones in rat brain slices by a selective D2 receptor antagonist L-741,626.
British journal of pharmacology 1996;119(7):1491-7.
1996: Linda J Bristow; Peter H Hutson; Janusz J Kulagowski; Paul D Leeson; S Matheson; Fraser Murray; D Rathbone; KL Saywell; L Thorn; Alan P Watt; mark david tricklebank
Anticonvulsant and behavioral profile of L-701,324, a potent, orally active antagonist at the glycine modulatory site on the N-methyl-D-aspartate receptor complex.
The Journal of pharmacology and experimental therapeutics 1996;279(2):492-501.
1996: Linda J Bristow; K L Flatman; Peter H Hutson; Janusz J Kulagowski; Paul D Leeson; L Young; mark david tricklebank
The atypical neuroleptic profile of the glycine/N-methyl-D-aspartate receptor antagonist, L-701,324, in rodents.
The Journal of pharmacology and experimental therapeutics 1996;277(2):578-85.
1996: Linda J Bristow; Gina P Cook; J C Gay; Janusz J Kulagowski; L Landon; Fraser Murray; KL Saywell; L Young; Peter H Hutson
The behavioural and neurochemical profile of the putative dopamine D3 receptor agonist, (+)-PD 128907, in the rat.
Neuropharmacology 1996;35(3):285-94.
1995: Angus M MacLeod; Sarah Grimwood; C Barton; Linda J Bristow; KL Saywell; George R Marshall; R G Ball
Identification of 3,5-dihydro-2-aryl-1H-pyrazolo[3,4-c]quinoline-1,4(2H)-diones as novel high-affinity glycine site N-methyl-D-aspartate antagonists.
Journal of medicinal chemistry 1995;38(12):2239-43.
1995: Peter H Hutson; Linda J Bristow; Joanna R Cunningham; J E Hogg; Jenny Longmore; Fraser Murray; D Pearce; Zerin Razzaque; KL Saywell; mark david tricklebank
The effects of GR127935, a putative 5-HT1D receptor antagonist, on brain 5-HT metabolism, extracellular 5-HT concentration and behaviour in the guinea pig.
Neuropharmacology 1995;34(4):383-92.
1995: Linda J Bristow; L Landon; KL Saywell; mark david tricklebank
The glycine/NMDA receptor antagonist, L-701,324 reverses isolation-induced deficits in prepulse inhibition in the rat.
Psychopharmacology 1995;118(2):230-2.
1994: Linda J Bristow; L Thorn; mark david tricklebank; Peter H Hutson
Competitive NMDA receptor antagonists attenuate the behavioural and neurochemical effects of amphetamine in mice.
European journal of pharmacology 1994;264(3):353-9.
1994: mark david tricklebank; Linda J Bristow; Peter H Hutson; Paul D Leeson; Michael Rowley; KL Saywell; L Singh; F David Tattersall; L Thorn; B J Williams
The anticonvulsant and behavioural profile of L-687,414, a partial agonist acting at the glycine modulatory site on the N-methyl-D-aspartate (NMDA) receptor complex.
British journal of pharmacology 1994;113(3):729-36.
1994: Linda J Bristow; L Young
Chromodacryorrhea and repetitive hind paw tapping: models of peripheral and central tachykinin NK1 receptor activation in gerbils.
European journal of pharmacology 1994;253(3):245-52.
1993: Linda J Bristow; Peter H Hutson; L Thorn; mark david tricklebank
The glycine/NMDA receptor antagonist, R-(+)-HA-966, blocks activation of the mesolimbic dopaminergic system induced by phencyclidine and dizocilpine (MK-801) in rodents.
British journal of pharmacology 1993;108(4):1156-63.
1992: mark david tricklebank; Linda J Bristow; Peter H Hutson
Alternative approaches to the discovery of novel antipsychotic agents.
Progress in drug research. Fortschritte der Arzneimittelforschung. Progrès des recherches pharmaceutiques 1992;38():299-336.
1991: Linda J Bristow; L Baucutt; L Thorn; Peter H Hutson; A Noble; M Beer; D N Middlemiss; mark david tricklebank
Behavioural and biochemical evidence of the interaction of the putative antipsychotic agent, BMY 14802 with the 5-HT1A receptor.
European journal of pharmacology 1991;204(1):21-8.
1991: Peter H Hutson; Linda J Bristow; L Thorn; mark david tricklebank
R-(+)-HA-966, a glycine/NMDA receptor antagonist, selectively blocks the activation of the mesolimbic dopamine system by amphetamine.
British journal of pharmacology 1991;103(4):2037-44.