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Benjamin Yerxa

Research Profile

Chemicals & Drugs

Disorders

Dry Eye Syndromes

Anatomy

Living Beings

Procedures

Phenomena

Safety

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Publications

TOP 3
James G Douglass; Roshni I Patel; Benjamin R Yerxa; Sammy R Shaver; Paul S Watson; Krzysztof Bednarski; Robert Plourde; Catherine C Redick; Kurt Brubaker; Arthur C Jones; José L Boyer
Lipophilic modifications to dinucleoside polyphosphates and nucleotides that confer antagonist properties at the platelet P2Y12 receptor.
Sammy R Shaver; Janet L Rideout; William Pendergast; James G Douglass; Edward G Brown; José L Boyer; Roshni I Patel; Catherine C Redick; Arthur C Jones; Maryse Picher; Benjamin R Yerxa
Structure-activity relationships of dinucleotides: Potent and selective agonists of P2Y receptors.
J Tauber; W F Davitt; J E Bokosky; Kelly K Nichols; Benjamin R Yerxa; A E Schaberg; Lisa M LaVange; M C Mills-Wilson; Donald J Kellerman
Double-masked, placebo-controlled safety and efficacy trial of diquafosol tetrasodium (INS365) ophthalmic solution for the treatment of dry eye.

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All Publications

2008: James G Douglass; Roshni I Patel; Benjamin R Yerxa; Sammy R Shaver; Paul S Watson; Krzysztof Bednarski; Robert Plourde; Catherine C Redick; Kurt Brubaker; Arthur C Jones; José L Boyer
Lipophilic modifications to dinucleoside polyphosphates and nucleotides that confer antagonist properties at the platelet P2Y12 receptor.
Journal of medicinal chemistry 2008;51(4):1007-25.
2005: Sammy R Shaver; Janet L Rideout; William Pendergast; James G Douglass; Edward G Brown; José L Boyer; Roshni I Patel; Catherine C Redick; Arthur C Jones; Maryse Picher; Benjamin R Yerxa
Structure-activity relationships of dinucleotides: Potent and selective agonists of P2Y receptors.
Purinergic signalling 2005;1(2):183-91.
2004: J Tauber; W F Davitt; J E Bokosky; Kelly K Nichols; Benjamin R Yerxa; A E Schaberg; Lisa M LaVange; M C Mills-Wilson; Donald J Kellerman
Double-masked, placebo-controlled safety and efficacy trial of diquafosol tetrasodium (INS365) ophthalmic solution for the treatment of dry eye.
Cornea 2004;23(8):784-92.
2004: Janet B Serle; Rong-Fang Wang; Ward M Peterson; Robert Plourde; Benjamin R Yerxa
Effect of 5-MCA-NAT, a putative melatonin MT3 receptor agonist, on intraocular pressure in glaucomatous monkey eyes.
Journal of glaucoma 2004;13(5):385-8.
2004: Kelly K Nichols; Benjamin R Yerxa; Donald J Kellerman
Diquafosol tetrasodium: a novel dry eye therapy.
Expert opinion on investigational drugs 2004;13(1):47-54.
2003: Matthew S Cowlen; Vivian Z Zhang; Lisa Warnock; Carolyn F Moyer; Ward M Peterson; Benjamin R Yerxa
Localization of ocular P2Y2 receptor gene expression by in situ hybridization.
Experimental eye research 2003;77(1):77-84.
2003: Randall J Kimple; Miller B Jones; Adam Shutes; Benjamin R Yerxa; David Siderovski; Francis S Willard
Established and emerging fluorescence-based assays for G-protein function: heterotrimeric G-protein alpha subunits and regulator of G-protein signaling (RGS) proteins.
Combinatorial chemistry & high throughput screening 2003;6(4):399-407.
2003: Kweonsik Min; Ricardo Munarriz; Benjamin R Yerxa; Irwin Goldstein; Sammy R Shaver; Matthew S Cowlen; Abdulmaged M Traish
Selective P2Y2 receptor agonists stimulate vaginal moisture in ovariectomized rabbits.
Fertility and sterility 2003;79(2):393-8.
2002: Arvydas Maminishkis; Stephen Jalickee; Sasha Blaug; Jodi Rymer; Benjamin R Yerxa; Ward M Peterson; Sheldon Miller
The P2Y(2) receptor agonist INS37217 stimulates RPE fluid transport in vitro and retinal reattachment in rat.
Investigative ophthalmology & visual science 2002;43(11):3555-66.
2002: Benjamin R Yerxa; Juan R Sabater; C William Davis; Monroe Stutts; M Lang-Furr; Maryse Picher; A C Jones; Matthew S Cowlen; R Dougherty; J Boyer; William W Abraham; Richard C Boucher
Pharmacology of INS37217 [P(1)-(uridine 5')-P(4)- (2'-deoxycytidine 5')tetraphosphate, tetrasodium salt], a next-generation P2Y(2) receptor agonist for the treatment of cystic fibrosis.
The Journal of pharmacology and experimental therapeutics 2002;302(3):871-80.
2002: Benjamin R Yerxa
Industry perspective.
Advances in experimental medicine and biology 2002;506(Pt B):1343-4.
2002: Benjamin R Yerxa; Mohan Mundasad; Robin N Sylvester; JoAnn C Garden; Mark Cooper; Donald J Kellerman
Ocular safety of INS365 ophthalmic solution, a P2Y2 agonist, in patients with mild to moderate dry eye disease.
Advances in experimental medicine and biology 2002;506(Pt B):1251-7.
2002: Benjamin R Yerxa; James G Douglass; Pierre-Paul Elena; Thierry Caillaud; Thierry Amar; Catherine Edick; Ward M Peterson
Potency and duration of action of synthetic P2Y2 receptor agonists on Schirmer scores in rabbits.
Advances in experimental medicine and biology 2002;506(Pt A):261-5.
2002: Hovhannes J Gukasyan; Benjamin R Yerxa; William Pendergast; Vincent H L Lee
Metabolism and transport of purinergic receptor agonists in rabbit conjunctival epithelial cells.
Advances in experimental medicine and biology 2002;506(Pt A):255-9.
2001: W Pendergast; Benjamin R Yerxa; J G Douglass; S R Shaver; R W Dougherty; C C Redick; I F Sims; J L Rideout
Synthesis and P2Y receptor activity of a series of uridine dinucleoside 5'-polyphosphates.
Bioorganic & medicinal chemistry letters 2001;11(2):157-60.