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Wen Shan Yew

Research Profile

Chemicals & Drugs

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Amino Acid Sequences

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Publications

TOP 3
Bo Xue; Lai Lai Yap; Amgalanbaatar Baldansuren; Jeng Yeong Chow; Sergei Dikanov; Yunn-Hwen Gan; Robert C Robinson; Wen Shan Yew
Structural evidence of a productive active site architecture for an evolved quorum-quenching GKL lactonase.
Maybelle Kho Go; Yan Ping Lim; Vivian Wing Ngar Cheung; Jeng Yeong Chow; Wen Shan Yew
Establishing a toolkit for precursor-directed polyketide biosynthesis: exploring substrate promiscuities of acid-CoA ligases.
Jeng Yeong Chow; Bo Xue; Kang Hao Lee; Alvin Tung; Long Wu; Robert C Robinson; Wen Shan Yew
Directed evolution of a thermostable quorum-quenching lactonase from the amidohydrolase superfamily.

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All Publications

2013: Bo Xue; Lai Lai Yap; Amgalanbaatar Baldansuren; Jeng Yeong Chow; Sergei Dikanov; Yunn-Hwen Gan; Robert C Robinson; Wen Shan Yew
Structural evidence of a productive active site architecture for an evolved quorum-quenching GKL lactonase.
Biochemistry 2013;52(13):2359-70.
2012: Maybelle Kho Go; Yan Ping Lim; Vivian Wing Ngar Cheung; Jeng Yeong Chow; Wen Shan Yew
Establishing a toolkit for precursor-directed polyketide biosynthesis: exploring substrate promiscuities of acid-CoA ligases.
Biochemistry 2012;51(22):4568-79.
2010: Jeng Yeong Chow; Bo Xue; Kang Hao Lee; Alvin Tung; Long Wu; Robert C Robinson; Wen Shan Yew
Directed evolution of a thermostable quorum-quenching lactonase from the amidohydrolase superfamily.
The Journal of biological chemistry 2010;285(52):40911-20.
2010: Shufen Huang; Jia Hui Chua; Wen Shan Yew; J Sivaraman; Philip K Moore; Choon-Hong Tan; Lih-Wen Deng
Site-directed mutagenesis on human cystathionine-gamma-lyase reveals insights into the modulation of H2S production.
Journal of molecular biology 2010;396(3):708-18.
2009: Jeng Yeong Chow; Long Wu; Wen Shan Yew
Directed evolution of a quorum-quenching lactonase from Mycobacterium avium subsp. paratuberculosis K-10 in the amidohydrolase superfamily.
Biochemistry 2009;48(20):4344-53.
2007: Wen Shan Yew; Alexander A Fedorov; Elena V Fedorov; Steven C Almo; John Alan Gerlt
Evolution of enzymatic activities in the enolase superfamily: L-talarate/galactarate dehydratase from Salmonella typhimurium LT2.
Biochemistry 2007;46(33):9564-77.
2006: Wen Shan Yew; Alexander A Fedorov; Elena V Fedorov; Bryant McKay Wood; Steven C Almo; John Alan Gerlt
Evolution of enzymatic activities in the enolase superfamily: D-tartrate dehydratase from Bradyrhizobium japonicum.
Biochemistry 2006;45(49):14598-608.
2006: Wen Shan Yew; Alexander A Fedorov; Elena V Fedorov; John F Rakus; Richard W Pierce; Steven C Almo; John Alan Gerlt
Evolution of enzymatic activities in the enolase superfamily: L-fuconate dehydratase from Xanthomonas campestris.
Biochemistry 2006;45(49):14582-97.
2006: Ayano Sakai; Dao Feng Xiang; Chengfu Xu; Ling Song; Wen Shan Yew; Frank M Raushel; John Alan Gerlt
Evolution of enzymatic activities in the enolase superfamily: N-succinylamino acid racemase and a new pathway for the irreversible conversion of D- to L-amino acids.
Biochemistry 2006;45(14):4455-62.
2005: Eric L Wise; Wen Shan Yew; Julie Akana; John Alan Gerlt; Ivan Rayment
Evolution of enzymatic activities in the orotidine 5'-monophosphate decarboxylase suprafamily: structural basis for catalytic promiscuity in wild-type and designed mutants of 3-keto-L-gulonate 6-phosphate decarboxylase.
Biochemistry 2005;44(6):1816-23.
2005: Wen Shan Yew; Julie Akana; Eric L Wise; Ivan Rayment; John Alan Gerlt
Evolution of enzymatic activities in the orotidine 5'-monophosphate decarboxylase suprafamily: enhancing the promiscuous D-arabino-hex-3-ulose 6-phosphate synthase reaction catalyzed by 3-keto-L-gulonate 6-phosphate decarboxylase.
Biochemistry 2005;44(6):1807-15.
2004: Eric L Wise; Wen Shan Yew; John Alan Gerlt; Ivan Rayment
Evolution of enzymatic activities in the orotidine 5'-monophosphate decarboxylase suprafamily: crystallographic evidence for a proton relay system in the active site of 3-keto-L-gulonate 6-phosphate decarboxylase.
Biochemistry 2004;43(21):6438-46.
2004: Wen Shan Yew; Eric L Wise; Ivan Rayment; John Alan Gerlt
Evolution of enzymatic activities in the orotidine 5'-monophosphate decarboxylase suprafamily: mechanistic evidence for a proton relay system in the active site of 3-keto-L-gulonate 6-phosphate decarboxylase.
Biochemistry 2004;43(21):6427-37.
2003: Eric L Wise; Wen Shan Yew; John Alan Gerlt; Ivan Rayment
Structural evidence for a 1,2-enediolate intermediate in the reaction catalyzed by 3-keto-L-gulonate 6-phosphate decarboxylase, a member of the orotidine 5'-monophosphate decarboxylase suprafamily.
Biochemistry 2003;42(42):12133-42.
2002: Eric L Wise; Wen Shan Yew; Patricia C Babbitt; John Alan Gerlt; Ivan Rayment
Homologous (beta/alpha)8-barrel enzymes that catalyze unrelated reactions: orotidine 5'-monophosphate decarboxylase and 3-keto-L-gulonate 6-phosphate decarboxylase.
Biochemistry 2002;41(12):3861-9.
2002: Wen Shan Yew; John Alan Gerlt
Utilization of L-ascorbate by Escherichia coli K-12: assignments of functions to products of the yjf-sga and yia-sgb operons.
Journal of bacteriology 2002;184(1):302-6.