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Shih-Jiun Yin

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Ching-Long Lai; Yeung-Pin Li; Chiu-Ming Liu; Hsiu-Shan Hsieh; Shih-Jiun Yin
Inhibition of human alcohol and aldehyde dehydrogenases by cimetidine and assessment of its effects on ethanol metabolism.
Chien-Ping Chiang; Ji-Lin Ho; Shou-Lun Lee; Shiao-Pieng Lee; Shin Nieh; Chew-Wun Wu; Shih-Jiun Yin
Expression pattern, ethanol-metabolizing activities, and cellular localization of alcohol and aldehyde dehydrogenases in human small intestine.
Ching-Long Lai; Jiunn-Tay Lee; Meng-Ta Liu; Chun-Chung Lu; Shih-Jiun Yin; Giia-Sheun Peng
Heavy binge drinking may increase risk of stroke in nonalcoholic hypertensives carrying variant ALDH2*2 gene allele.

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2013: Ching-Long Lai; Yeung-Pin Li; Chiu-Ming Liu; Hsiu-Shan Hsieh; Shih-Jiun Yin
Inhibition of human alcohol and aldehyde dehydrogenases by cimetidine and assessment of its effects on ethanol metabolism.
Chemico-biological interactions 2013;202(1-3):275-82.
2012: Chien-Ping Chiang; Ji-Lin Ho; Shou-Lun Lee; Shiao-Pieng Lee; Shin Nieh; Chew-Wun Wu; Shih-Jiun Yin
Expression pattern, ethanol-metabolizing activities, and cellular localization of alcohol and aldehyde dehydrogenases in human small intestine.
Alcoholism, clinical and experimental research 2012;36(12):2047-58.
2012: Ching-Long Lai; Jiunn-Tay Lee; Meng-Ta Liu; Chun-Chung Lu; Shih-Jiun Yin; Giia-Sheun Peng
Heavy binge drinking may increase risk of stroke in nonalcoholic hypertensives carrying variant ALDH2*2 gene allele.
Acta neurologica Taiwanica 2012;21(1):39-43.
2011: Shou-Lun Lee; Hsuan-Ting Shih; Yu-Chou Chi; Yeung-Pin Li; Shih-Jiun Yin
Oxidation of methanol, ethylene glycol, and isopropanol with human alcohol dehydrogenases and the inhibition by ethanol and 4-methylpyrazole.
Chemico-biological interactions 2011;191(1-3):26-31.
2010: Chung-Tay Yao; Ching-Long Lai; Hsiu-Shan Hsieh; Chin-Wen Chi; Shih-Jiun Yin
Establishment of steady-state metabolism of ethanol in perfused rat liver: the quantitative analysis using kinetic mechanism-based rate equations of alcohol dehydrogenase.
Alcohol (Fayetteville, N.Y.) 2010;44(6):541-51.
2009: Yi-Chyan Chen; Giia-Sheun Peng; Tien-Ping Tsao; Ming-Fang Wang; Ru-Band Lu; Shih-Jiun Yin
Pharmacokinetic and pharmacodynamic basis for overcoming acetaldehyde-induced adverse reaction in Asian alcoholics, heterozygous for the variant ALDH2*2 gene allele.
Pharmacogenetics and genomics 2009;19(8):588-99.
2009: Chien-Ping Chiang; Cheng-Wen Wu; Shiao-Pieng Lee; Chia-Chi Chung; Chi-Wei Wang; Shou-Lun Lee; Shin Nieh; Shih-Jiun Yin
Expression pattern, ethanol-metabolizing activities, and cellular localization of alcohol and aldehyde dehydrogenases in human pancreas: implications for pathogenesis of alcohol-induced pancreatic injury.
Alcoholism, clinical and experimental research 2009;33(6):1059-68.
2009: Yi-Chyan Chen; Giia-Sheun Peng; Ming-Fang Wang; Tien-Ping Tsao; Shih-Jiun Yin
Polymorphism of ethanol-metabolism genes and alcoholism: correlation of allelic variations with the pharmacokinetic and pharmacodynamic consequences.
Chemico-biological interactions 2009;178(1-3):2-7.
2009: Ming-Fang Wang; Chih-Li Han; Shih-Jiun Yin
Substrate specificity of human and yeast aldehyde dehydrogenases.
Chemico-biological interactions 2009;178(1-3):36-9.
2009: Giia-Sheun Peng; Shih-Jiun Yin
Effect of the allelic variants of aldehyde dehydrogenase ALDH2*2 and alcohol dehydrogenase ADH1B*2 on blood acetaldehyde concentrations.
Human genomics 2009;3(2):121-7.
2008: Chiao-Chicy Chen; Shih-Jiun Yin
Alcohol abuse and related factors in Asia.
International review of psychiatry (Abingdon, England) 2008;20(5):425-33.
2007: Giia-Sheun Peng; Yi-Chyan Chen; Tien-Ping Tsao; Ming-Fang Wang; Shih-Jiun Yin
Pharmacokinetic and pharmacodynamic basis for partial protection against alcoholism in Asians, heterozygous for the variant ALDH2*2 gene allele.
Pharmacogenetics and genomics 2007;17(10):845-55.
2007: Shih-Jiun Yin; Giia-Sheun Peng
Acetaldehyde, polymorphisms and the cardiovascular system.
Novartis Foundation symposium 2007;285():52-63; discusion 63-8, 198-9.
2007: Giia-Sheun Peng; Shih-Jiun Yin; Chun-An Cheng; Shao-Wen Chiu; Jiunn-Tay Lee; Wei-Wen Lin; Jiann-Chyun Lin; Yaw-Don Hsu
Increased risk of cerebral hemorrhage in Chinese male heavy drinkers with mild liver disorder.
Cerebrovascular diseases (Basel, Switzerland) 2007;23(4):309-14.
2006: Shou-Lun Lee; Gar-Yang Chau; Chung-Tay Yao; Cheng-Wen Wu; Shih-Jiun Yin
Functional assessment of human alcohol dehydrogenase family in ethanol metabolism: significance of first-pass metabolism.
Alcoholism, clinical and experimental research 2006;30(7):1132-42.
2006: Shiao-Pieng Lee; Chien-Ping Chiang; Shou-Lun Lee; Yi-Jan Hsia; Tzu-Ling Chuang; Jau-Chen Lin; San-Chi Liang; Shih Nieh; Shih-Jiun Yin
Immunochemical features in the classification of human alcohol dehydrogenase family.
Alcohol (Fayetteville, N.Y.) 2006;39(1):13-20.
2005: Fu-Chuo Peng; Sheng-Hui Tang; Ming-Chi Huang; Chiao-Chicy Chen; Tsung-Li Kuo; Shih-Jiun Yin
Oxidative status in patients with alcohol dependence: a clinical study in Taiwan.
Journal of toxicology and environmental health. Part A 2005;68(17-18):1497-509.
2005: Li-Chen Ma; Shou-Lun Lee; Cha-Ze Lee; Shih-Jiun Yin; Jann-Tay Wang
Molecular cloning and kinetic characterization of an aldehyde dehydrogenase gene in Klebsiella pneumoniae.
Journal of the Formosan Medical Association = Taiwan yi zhi 2005;104(4):221-30.
2004: Shou-Lun Lee; Jan-Olov Höög; Shih-Jiun Yin
Functionality of allelic variations in human alcohol dehydrogenase gene family: assessment of a functional window for protection against alcoholism.
Pharmacogenetics 2004;14(11):725-32.
2004: Chiao-Chicy Chen; Chian-Jue Kuo; SHANG YING TSAI; Shih-Jiun Yin
Relation of genotypes of alcohol metabolizing enzymes and mortality of liver diseases in patients with alcohol dependence.
Addiction biology 2004;9(3-4):233-7.
2004: San-Yuan Huang; Wei-Wen Lin; Huei-Chen Ko; Jia-Fu Lee; Tso-Jen Wang; Yuan-Hwa Chou; Shih-Jiun Yin; Ru-Band Lu
Possible interaction of alcohol dehydrogenase and aldehyde dehydrogenase genes with the dopamine D2 receptor gene in anxiety-depressive alcohol dependence.
Alcoholism, clinical and experimental research 2004;28(3):374-84.
2003: Shou-Lun Lee; Ming-Fang Wang; An-I Lee; Shih-Jiun Yin
The metabolic role of human ADH3 functioning as ethanol dehydrogenase.
FEBS letters 2003;544(1-3):143-7.
2003: Shih-Jiun Yin; Chu-Fang Chou; Ching-Long Lai; Shou-Lun Lee; Chih-Li Han
Human class IV alcohol dehydrogenase: kinetic mechanism, functional roles and medical relevance.
Chemico-biological interactions 2003;143-144():219-27.
2002: Giia-Sheun Peng; Jiu-Haw Yin; Ming-Fang Wang; Jiuun-Tay Lee; Yaw-Don Hsu; Shih-Jiun Yin
Alcohol sensitivity in Taiwanese men with different alcohol and aldehyde dehydrogenase genotypes.
Journal of the Formosan Medical Association = Taiwan yi zhi 2002;101(11):769-74.
2002: Chu-Fang Chou; Ching-Long Lai; Yen-Chun Chang; Gregg Duester; Shih-Jiun Yin
Kinetic mechanism of human class IV alcohol dehydrogenase functioning as retinol dehydrogenase.
The Journal of biological chemistry 2002;277(28):25209-16.
2000: Ching-Long Lai; Y C Chao; Y C Chen; CS Liao; M C Chen; Y C Liu; Shih-Jiun Yin
No sex and age influence on the expression pattern and activities of human gastric alcohol and aldehyde dehydrogenases.
Alcoholism, clinical and experimental research 2000;24(11):1625-32.
1999: Yi-Chyan Chen; Ru-Band Lu; Giia-Sheun Peng; Ming-Fang Wang; H K Wang; Huei-Chen Ko; Y C Chang; J J Lu; TK Li; Shih-Jiun Yin
Alcohol metabolism and cardiovascular response in an alcoholic patient homozygous for the ALDH2*2 variant gene allele.
Alcoholism, clinical and experimental research 1999;23(12):1853-60.
1999: Chiao-Chicy Chen; Ru-Band Lu; Yi-Chyan Chen; Ming-Fang Wang; Y C Chang; TK Li; Shih-Jiun Yin
Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism.
American journal of human genetics 1999;65(3):795-807.
1999: Giia-Sheun Peng; Ming-Fang Wang; C Y Chen; S U Luu; H C Chou; TK Li; Shih-Jiun Yin
Involvement of acetaldehyde for full protection against alcoholism by homozygosity of the variant allele of mitochondrial aldehyde dehydrogenase gene in Asians.
Pharmacogenetics 1999;9(4):463-76.
1999: Gregg Duester; Jaume Farrés; Michael R Felder; R S Holmes; Jan-Olov Höög; Xavier Parés; Bryce V Plapp; Shih-Jiun Yin; H Jörnvall
Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family.
Biochemical pharmacology 1999;58(3):389-95.
1999: J F Lee; Ru-Band Lu; Huei-Chen Ko; F M Chang; Shih-Jiun Yin; Andrew J Pakstis; K K Kidd
No association between DRD2 locus and alcoholism after controlling the ADH and ALDH genotypes in Chinese Han population.
Alcoholism, clinical and experimental research 1999;23(4):592-9.
1999: Michael V Osier; Andrew J Pakstis; Judith R Kidd; J F Lee; Shih-Jiun Yin; Huei-Chen Ko; Howard J Edenberg; Ru-Band Lu; Kenneth K Kidd
Linkage disequilibrium at the ADH2 and ADH3 loci and risk of alcoholism.
American journal of human genetics 1999;64(4):1147-57.
1999: Shih-Jiun Yin; Chih-Li Han; A I Lee; Cheng-Wen Wu
Human alcohol dehydrogenase family. Functional classification, ethanol/retinol metabolism, and medical implications.
Advances in experimental medicine and biology 1999;463():265-74.
1998: Chih-Li Han; CS Liao; Cheng-Wen Wu; C L Hwong; An-Rong Lee; Shih-Jiun Yin
Contribution to first-pass metabolism of ethanol and inhibition by ethanol for retinol oxidation in human alcohol dehydrogenase family--implications for etiology of fetal alcohol syndrome and alcohol-related diseases.
European journal of biochemistry / FEBS 1998;254(1):25-31.
1997: Chung-Tay Yao; CS Liao; Shih-Jiun Yin
Human hepatic alcohol and aldehyde dehydrogenases: genetic polymorphism and activities.
Proceedings of the National Science Council, Republic of China. Part B, Life sciences 1997;21(3):106-11.
1997: Shih-Jiun Yin; CS Liao; Cheng-Wen Wu; T T Li; L L Chen; Ching-Long Lai; T Y Tsao
Human stomach alcohol and aldehyde dehydrogenases: comparison of expression pattern and activities in alimentary tract.
Gastroenterology 1997;112(3):766-75.
1997: Shih-Jiun Yin; Chih-Li Han; CS Liao; Cheng-Wen Wu
Expression, activities, and kinetic mechanism of human stomach alcohol dehydrogenase. Inference for first-pass metabolism of ethanol in mammals.
Advances in experimental medicine and biology 1997;414():347-55.
1996: Lucinda G Carr; I S Yi; Ting-Kai Li; Shih-Jiun Yin
Cytochrome P4502E1 genotypes, alcoholism, and alcoholic cirrhosis in Han Chinese and Atayal Natives of Taiwan.
Alcoholism, clinical and experimental research 1996;20(1):43-6.
1995: S U Luu; Ming-Fang Wang; D L Lin; M H Kao; M L Chen; C H Chiang; L Pai; Shih-Jiun Yin
Ethanol and acetaldehyde metabolism in chinese with different aldehyde dehydrogenase-2 genotypes.
Proceedings of the National Science Council, Republic of China. Part B, Life sciences 1995;19(3):129-36.
1995: Shih-Jiun Yin; Ming-Fang Wang; Chih-Li Han; S L Wang
Substrate binding pocket structure of human aldehyde dehydrogenases. A substrate specificity approach.
Advances in experimental medicine and biology 1995;372():9-16.
1994: Shih-Jiun Yin; CS Liao; Y C Lee; Cheng-Wen Wu; S W Jao
Genetic polymorphism and activities of human colon alcohol and aldehyde dehydrogenases: no gender and age differences.
Alcoholism, clinical and experimental research 1994;18(5):1256-60.
1994: You-Chen Chao; Ming-Fang Wang; Hung-Shang Tang; C T Hsu; Shih-Jiun Yin
Genotyping of alcohol dehydrogenase at the ADH2 and ADH3 loci by using a polymerase chain reaction and restriction-fragment-length polymorphism in Chinese alcoholic cirrhotics and non-alcoholics.
Proceedings of the National Science Council, Republic of China. Part B, Life sciences 1994;18(3):101-6.
1994: H R Thomasson; David W Crabb; Howard J Edenberg; Ting-Kai Li; H G Hwu; C C Chen; E K Yeh; Shih-Jiun Yin
Low frequency of the ADH2*2 allele among Atayal natives of Taiwan with alcohol use disorders.
Alcoholism, clinical and experimental research 1994;18(3):640-3.
1994: You-Chen Chao; S R Liou; Y Y Chung; Hung-Shang Tang; C T Hsu; T K Li; Shih-Jiun Yin
Polymorphism of alcohol and aldehyde dehydrogenase genes and alcoholic cirrhosis in Chinese patients.
Hepatology (Baltimore, Md.) 1994;19(2):360-6.
1994: Shih-Jiun Yin
Alcohol dehydrogenase: enzymology and metabolism.
Alcohol and alcoholism (Oxford, Oxfordshire). Supplement 1994;2():113-9.
1993: You-Chen Chao; S R Liou; S F Tsai; Shih-Jiun Yin
Dominance of the mutant ALDH2(2) allele in the expression of human stomach aldehyde dehydrogenase-2 activity.
Proceedings of the National Science Council, Republic of China. Part B, Life sciences 1993;17(3):98-102.
1993: Shih-Jiun Yin; F J Chou; S F Chao; S F Tsai; CS Liao; S L Wang; Cheng-Wen Wu; S C Lee
Alcohol and aldehyde dehydrogenases in human esophagus: comparison with the stomach enzyme activities.
Alcoholism, clinical and experimental research 1993;17(2):376-81.
1993: Shih-Jiun Yin; S L Wang; CS Liao; H Jörnvall
Human high-Km aldehyde dehydrogenase (ALDH3): molecular, kinetic and structural features.
Advances in experimental medicine and biology 1993;328():87-98.
1992: Shih-Jiun Yin; CS Liao; C M Chen; F T Fan; S C Lee
Genetic polymorphism and activities of human lung alcohol and aldehyde dehydrogenases: implications for ethanol metabolism and cytotoxicity.
Biochemical genetics 1992;30(3-4):203-15.
1991: H R Thomasson; Howard J Edenberg; David W Crabb; X L Mai; R E Jerome; Ting-Kai Li; S P Wang; Y T Lin; Ru-Band Lu; Shih-Jiun Yin
Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men.
American journal of human genetics 1991;48(4):677-81.
1991: CS Liao; J S Lin; C P Chang; T J Chao; You-Chen Chao; T C Cheng; Cheng-Wen Wu; Shih-Jiun Yin
Stomach and duodenal alcohol and aldehyde dehydrogenase isozymes in Chinese.
Proceedings of the National Science Council, Republic of China. Part B, Life sciences 1991;15(2):92-6.
1990: Shih-Jiun Yin; Ming-Fang Wang; CS Liao; C M Chen; Cheng-Wen Wu
Identification of a human stomach alcohol dehydrogenase with distinctive kinetic properties.
Biochemistry international 1990;22(5):829-35.
1990: S L Wang; Cheng-Wen Wu; T C Cheng; Shih-Jiun Yin
Isolation of high-Km aldehyde dehydrogenase isoenzymes from human gastric mucosa.
Biochemistry international 1990;22(2):199-204.
1989: Shih-Jiun Yin; CS Liao; S L Wang; Y J Chen; Cheng-Wen Wu
Kinetic evidence for human liver and stomach aldehyde dehydrogenase-3 representing an unique class of isozymes.
Biochemical genetics 1989;27(5-6):321-31.
1989: S C Lee; J S Lin; F J Chou; Shih-Jiun Yin
Lung alcohol and aldehyde dehydrogenase isoenzymes in Chinese.
Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association 1989;88(5):437-42.
1988: Shih-Jiun Yin; T C Cheng; C P Chang; Y J Chen; You-Chen Chao; Hung-Shang Tang; T M Chang; Cheng-Wen Wu
Human stomach alcohol and aldehyde dehydrogenases (ALDH): a genetic model proposed for ALDH III isozymes.
Biochemical genetics 1988;26(5-6):343-60.
1987: T J Chao; C P Chang; M C Chang; H C Liu; J Wang; Shih-Jiun Yin
Liver alcohol and aldehyde dehydrogenase isoenzymes in Chinese.
Proceedings of the National Science Council, Republic of China. Part B, Life sciences 1987;11(3):260-5.