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Linda Britton

Research Profile

Chemicals & Drugs

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TOP 3
Patrick J Baker; K Linda Britton; Martin Fisher; Julia Esclapez; Carmen Pire; María José Bonete; Juan Ferrer; David Rice
Active site dynamics in the zinc-dependent medium chain alcohol dehydrogenase superfamily.
K Linda Britton; Patrick J Baker; Martin Fisher; Sergey N Ruzheinikov; D James Gilmour; María José Bonete; Juan Ferrer; Carmen Pire; Julia Esclapez; David Rice
Analysis of protein solvent interactions in glucose dehydrogenase from the extreme halophile Haloferax mediterranei.
Julia Esclapez; K Linda Britton; Patrick J Baker; Martin Fisher; Carmen Pire; Juan Ferrer; María José Bonete; David Rice
Crystallization and preliminary X-ray analysis of binary and ternary complexes of Haloferax mediterranei glucose dehydrogenase.

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All Publications

2009: Patrick J Baker; K Linda Britton; Martin Fisher; Julia Esclapez; Carmen Pire; María José Bonete; Juan Ferrer; David Rice
Active site dynamics in the zinc-dependent medium chain alcohol dehydrogenase superfamily.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(3):779-84.
2006: K Linda Britton; Patrick J Baker; Martin Fisher; Sergey N Ruzheinikov; D James Gilmour; María José Bonete; Juan Ferrer; Carmen Pire; Julia Esclapez; David Rice
Analysis of protein solvent interactions in glucose dehydrogenase from the extreme halophile Haloferax mediterranei.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(13):4846-51.
2005: Julia Esclapez; K Linda Britton; Patrick J Baker; Martin Fisher; Carmen Pire; Juan Ferrer; María José Bonete; David Rice
Crystallization and preliminary X-ray analysis of binary and ternary complexes of Haloferax mediterranei glucose dehydrogenase.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 8):743-6.
2003: Stephen Y K Seah; K Linda Britton; David Rice; Yasuhisa Asano; Paul C Engel
Kinetic analysis of phenylalanine dehydrogenase mutants designed for aliphatic amino acid dehydrogenase activity with guidance from homology-based modelling.
European journal of biochemistry / FEBS 2003;270(23):4628-34.
2002: Stephen Y K Seah; K Linda Britton; David Rice; Yasuhisa Asano; Paul C Engel
Single amino acid substitution in Bacillus sphaericus phenylalanine dehydrogenase dramatically increases its discrimination between phenylalanine and tyrosine substrates.
Biochemistry 2002;41(38):11390-7.
2001: XG Wang; K Linda Britton; Timothy J Stillman; David Rice; Paul C Engel
Conversion of a glutamate dehydrogenase into methionine/norleucine dehydrogenase by site-directed mutagenesis.
European journal of biochemistry / FEBS 2001;268(22):5791-9.
2001: K Linda Britton; I S Abeysinghe; Patrick J Baker; Vladimir V Barynin; P Diehl; Sean Langridge; B A McFadden; Svetlana E Sedelnikova; Timothy J Stillman; K Weeradechapon; David Rice
The structure and domain organization of Escherichia coli isocitrate lyase.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 9):1209-18.
2001: Suzie Coughlan; XG Wang; K Linda Britton; Timothy J Stillman; David Rice; Roberta Chiaraluce; Valerio Consalvi; Roberto Scandurra; Paul C Engel
Contribution of an aspartate residue, D114, in the active site of clostridial glutamate dehydrogenase to the enzyme's unusual pH dependence.
Biochimica et biophysica acta 2001;1544(1-2):10-7.
1999: K Linda Britton; KS Yip; Svetlana E Sedelnikova; Timothy J Stillman; Michael W W Adams; K Ma; Dennis L Maeder; Frank Thomson Robb; N Tolliday; Costantino Vetriani; David Rice; Patrick J Baker
Structure determination of the glutamate dehydrogenase from the hyperthermophile Thermococcus litoralis and its comparison with that from Pyrococcus furiosus.
Journal of molecular biology 1999;293(5):1121-32.
1999: Timothy J Stillman; A M Migueis; XG Wang; Patrick J Baker; K Linda Britton; Paul C Engel; David Rice
Insights into the mechanism of domain closure and substrate specificity of glutamate dehydrogenase from Clostridium symbiosum.
Journal of molecular biology 1999;285(2):875-85.
1998: Costantino Vetriani; Dennis L Maeder; N Tolliday; KS Yip; Timothy J Stillman; K Linda Britton; David Rice; H H Klump; Frank Thomson Robb
Protein thermostability above 100 degreesC: a key role for ionic interactions.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(21):12300-5.
1998: KS Yip; K Linda Britton; Timothy J Stillman; J Lebbink; WILLEM DE VOS; Frank Thomson Robb; Costantino Vetriani; Dennis L Maeder; David Rice
Insights into the molecular basis of thermal stability from the analysis of ion-pair networks in the glutamate dehydrogenase family.
European journal of biochemistry / FEBS 1998;255(2):336-46.
1998: K Linda Britton; Y Asano; David Rice
Crystal structure and active site location of N-(1-D-carboxylethyl)-L-norvaline dehydrogenase.
Nature structural biology 1998;5(7):593-601.
1998: K Linda Britton; Timothy J Stillman; KS Yip; P Forterre; Paul C Engel; David Rice
Insights into the molecular basis of salt tolerance from the study of glutamate dehydrogenase from Halobacterium salinarum.
The Journal of biological chemistry 1998;273(15):9023-30.
1998: S Millevoi; Alessandra Pasquo; Roberta Chiaraluce; Valerio Consalvi; Laura Giangiacomo; K Linda Britton; Timothy J Stillman; David Rice; Paul C Engel
A monomeric mutant of Clostridium symbiosum glutamate dehydrogenase: comparison with a structured monomeric intermediate obtained during refolding.
Protein science : a publication of the Protein Society 1998;7(4):966-74.
1998: Alessandra Pasquo; K Linda Britton; Patrick J Baker; G Brearley; R J Hinton; Arthur J G Moir; Timothy J Stillman; David Rice
Crystallization of NAD+-dependent phenylalanine dehydrogenase from Nocardia sp239.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 2):269-72.
1998: K Linda Britton; H F Rogers; Y Asano; T Dairi; Y Kato; Timothy J Stillman
Crystallization of Arthrobacter sp. strain 1C N-(1-D-carboxyethyl)-L- norvaline dehydrogenase and its complex with NAD+.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 1):124-6.
1996: Alessandra Pasquo; K Linda Britton; Timothy J Stillman; David Rice; H Cölfen; S E Harding; Roberto Scandurra; Paul C Engel
Construction of a dimeric form of glutamate dehydrogenase from Clostridium symbiosum by site-directed mutagenesis.
Biochimica et biophysica acta 1996;1297(2):149-58.
1996: David Rice; KS Yip; Timothy J Stillman; K Linda Britton; A Fuentes; I Connerton; Alessandra Pasquo; R Scandura; Paul C Engel
Insights into the molecular basis of thermal stability from the structure determination of Pyrococcus furiosus glutamate dehydrogenase.
FEMS microbiology reviews 1996;18(2-3):105-17.
1996: S Coughlan; XG Wang; K Linda Britton; Timothy J Stillman; David Rice; Paul C Engel
Preliminary functional studies of mutant D114N of Clostridium symbiosum glutamate dehydrogenase.
Biochemical Society transactions 1996;24(1):149S.
1995: KS Yip; Timothy J Stillman; K Linda Britton; Peter J Artymiuk; Patrick J Baker; Svetlana E Sedelnikova; Paul C Engel; Alessandra Pasquo; Roberta Chiaraluce; Valerio Consalvi
The structure of Pyrococcus furiosus glutamate dehydrogenase reveals a key role for ion-pair networks in maintaining enzyme stability at extreme temperatures.
Structure (London, England : 1993) 1995;3(11):1147-58.
1995: S Y Seah; K Linda Britton; P J Baker; David Rice; Y Asano; Paul C Engel
Alteration in relative activities of phenylalanine dehydrogenase towards different substrates by site-directed mutagenesis.
FEBS letters 1995;370(1-2):93-6.
1995: K Linda Britton; Patrick J Baker; K M Borges; Paul C Engel; Alessandra Pasquo; David Rice; Frank Thomson Robb; Roberto Scandurra; Timothy J Stillman; KS Yip
Insights into thermal stability from a comparison of the glutamate dehydrogenases from Pyrococcus furiosus and Thermococcus litoralis.
European journal of biochemistry / FEBS 1995;229(3):688-95.
1995: J K Teller; Patrick J Baker; K Linda Britton; Paul C Engel; David Rice; Timothy J Stillman
Correlation of intron-exon organisation with the three-dimensional structure in glutamate dehydrogenase.
Biochimica et biophysica acta 1995;1247(2):231-8.
1995: KS Yip; Patrick J Baker; K Linda Britton; Paul C Engel; David Rice; Svetlana E Sedelnikova; Timothy J Stillman; Alessandra Pasquo; Roberta Chiaraluce; Valerio Consalvi; Roberto Scandurra
Crystallization of the NAD(P)-dependent glutamate dehydrogenase from the hyperthermophile Pyrococcus furiosus.
Acta crystallographica. Section D, Biological crystallography 1995;51(Pt 2):240-2.
1995: XG Wang; K Linda Britton; Patrick J Baker; S Martin; David Rice; Paul C Engel
Alteration of the amino acid substrate specificity of clostridial glutamate dehydrogenase by site-directed mutagenesis of an active-site lysine residue.
Protein engineering 1995;8(2):147-52.
1994: XG Wang; Jonathan L E Dean; Paul C Engel; Patrick J Baker; K Linda Britton; Timothy J Stillman; David Rice
The changed pattern of substrate specificity in the K89L mutant of glutamate dehydrogenase of Clostridium symbiosum.
Biochemical Society transactions 1994;22(3):320S.
1994: Jonathan L E Dean; XG Wang; J K Teller; M L Waugh; K Linda Britton; Patrick J Baker; Timothy J Stillman; S R Martin; David Rice; Paul C Engel
The catalytic role of aspartate in the active site of glutamate dehydrogenase.
The Biochemical journal 1994;301 ( Pt 1)():13-6.
1993: K Linda Britton; Patrick J Baker; Paul C Engel; David Rice; Timothy J Stillman
Evolution of substrate diversity in the superfamily of amino acid dehydrogenases. Prospects for rational chiral synthesis.
Journal of molecular biology 1993;234(4):938-45.
1993: Timothy J Stillman; Patrick J Baker; K Linda Britton; David Rice
Conformational flexibility in glutamate dehydrogenase. Role of water in substrate recognition and catalysis.
Journal of molecular biology 1993;234(4):1131-9.
1992: Patrick J Baker; K Linda Britton; David Rice; A Rob; Timothy J Stillman
Structural consequences of sequence patterns in the fingerprint region of the nucleotide binding fold. Implications for nucleotide specificity.
Journal of molecular biology 1992;228(2):662-71.
1992: K Linda Britton; Patrick J Baker; David Rice; Timothy J Stillman
Structural relationship between the hexameric and tetrameric family of glutamate dehydrogenases.
European journal of biochemistry / FEBS 1992;209(3):851-9.
1992: Timothy J Stillman; Patrick J Baker; K Linda Britton; David Rice; H F Rodgers
Effect of additives on the crystallization of glutamate dehydrogenase from Clostridium symbiosum. Evidence for a ligand-induced conformational change.
Journal of molecular biology 1992;224(4):1181-4.
1992: Patrick J Baker; K Linda Britton; Paul C Engel; G W Farrants; K S Lilley; David Rice; Timothy J Stillman
Subunit assembly and active site location in the structure of glutamate dehydrogenase.
Proteins 1992;12(1):75-86.
1991: K S Lilley; Patrick J Baker; K Linda Britton; Timothy J Stillman; P E Brown; Arthur J G Moir; Paul C Engel; David Rice; J E Bell; E Bell
The partial amino acid sequence of the NAD(+)-dependent glutamate dehydrogenase of Clostridium symbiosum: implications for the evolution and structural basis of coenzyme specificity.
Biochimica et biophysica acta 1991;1080(3):191-7.