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Hannele Yki-Järvinen

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
Kotronen Anna; Seppälä-Lindroos Anneli; Vehkavaara Satu; Bergholm Robert; Frayn Keith N; Fielding Barbara A; Yki-Järvinen Hannele
Liver fat and lipid oxidation in humans.
Kotronen Anna; Peltonen Markku; Hakkarainen Antti; Sevastianova Ksenia; Bergholm Robert; Johansson Lina M; Lundbom Nina; Rissanen Aila; Ridderstråle Martin; Groop Leif; Orho-Melander Marju; Yki-Järvinen Hannele
Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors.
Kotronen A; Johansson L E; Johansson L M; Roos C; Westerbacka J; Hamsten A; Bergholm R; Arkkila P; Arola J; Kiviluoto T; Fisher R M; Ehrenborg E; Orho-Melander M; Ridderstråle M; Groop L; Yki-Järvinen H
A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans.

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All Publications

2009: Kotronen Anna; Seppälä-Lindroos Anneli; Vehkavaara Satu; Bergholm Robert; Frayn Keith N; Fielding Barbara A; Yki-Järvinen Hannele
Liver fat and lipid oxidation in humans.
Liver international : official journal of the International Association for the Study of the Liver 2009;29(9):1439-46.
2009: Kotronen Anna; Peltonen Markku; Hakkarainen Antti; Sevastianova Ksenia; Bergholm Robert; Johansson Lina M; Lundbom Nina; Rissanen Aila; Ridderstråle Martin; Groop Leif; Orho-Melander Marju; Yki-Järvinen Hannele
Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors.
Gastroenterology 2009;137(3):865-72.
2009: Kotronen A; Johansson L E; Johansson L M; Roos C; Westerbacka J; Hamsten A; Bergholm R; Arkkila P; Arola J; Kiviluoto T; Fisher R M; Ehrenborg E; Orho-Melander M; Ridderstråle M; Groop L; Yki-Järvinen H
A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans.
Diabetologia 2009;52(6):1056-60.
2009: Makkonen Janne; Pietiläinen Kirsi H; Rissanen Aila; Kaprio Jaakko; Yki-Järvinen Hannele
Genetic factors contribute to variation in serum alanine aminotransferase activity independent of obesity and alcohol: a study in monozygotic and dizygotic twins.
Journal of hepatology 2009;50(5):1035-42.
2009: Bunck Mathijs C; Diamant Michaela; Cornér Anja; Eliasson Bjorn; Malloy Jaret L; Shaginian Rimma M; Deng Wei; Kendall David M; Taskinen Marja-Riitta; Smith Ulf; Yki-Järvinen Hannele; Heine Robert J
One-year treatment with exenatide improves beta-cell function, compared with insulin glargine, in metformin-treated type 2 diabetic patients: a randomized, controlled trial.
Diabetes care 2009;32(5):762-8.
2009: Juurinen L; Tiikkainen M; Saltevo J; Nikkilä K; Lanki H; Leppävuori E; Kock T; Teikari-Myyrä T; Kauppinen-Mäkelin R; Kotronen A; Yki-Järvinen H
Nateglinide combination therapy with basal insulin and metformin in patients with Type 2 diabetes.
Diabetic medicine : a journal of the British Diabetic Association 2009;26(4):409-15.
2009: Kotronen A; Velagapudi V R; Yetukuri L; Westerbacka J; Bergholm R; Ekroos K; Makkonen J; Taskinen M-R; Oresic M; Yki-Järvinen H
Serum saturated fatty acids containing triacylglycerols are better markers of insulin resistance than total serum triacylglycerol concentrations.
Diabetologia 2009;52(4):684-90.
2009: Kotronen Anna; Yki-Järvinen Hannele; Aminoff Anna; Bergholm Robert; Pietiläinen Kirsi H; Westerbacka Jukka; Talmud Philippa J; Humphries Steve E; Hamsten Anders; Isomaa Bo; Groop Leif; Orho-Melander Marju; Ehrenborg Ewa; Fisher Rachel M
Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts.
European journal of endocrinology / European Federation of Endocrine Societies 2009;160(4):593-602.
2009: Tikka Saara; Mykkänen Kati; Ruchoux Marie-Magdeleine; Bergholm Robert; Junna Maija; Pöyhönen Minna; Yki-Järvinen Hannele; Joutel Anne; Viitanen Matti; Baumann Marc; Kalimo Hannu
Congruence between NOTCH3 mutations and GOM in 131 CADASIL patients.
Brain : a journal of neurology 2009;132(Pt 4):933-9.
2009: Kotronen Anna; Seppänen-Laakso Tuulikki; Westerbacka Jukka; Kiviluoto Tuula; Arola Johanna; Ruskeepää Anna-Liisa; Oresic Matej; Yki-Järvinen Hannele
Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver.
Diabetes 2009;58(1):203-8.
2008: Kotronen Anna; Lewitt Moira; Hall Kerstin; Brismar Kerstin; Yki-Järvinen Hannele
Insulin-like growth factor binding protein 1 as a novel specific marker of hepatic insulin sensitivity.
The Journal of clinical endocrinology and metabolism 2008;93(12):4867-72.
2008: Kotronen Anna; Juurinen Leena; Tiikkainen Mirja; Vehkavaara Satu; Yki-Järvinen Hannele
Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes.
Gastroenterology 2008;135(1):122-30.
2008: Mustelin Linda; Pietiläinen Kirsi H; Rissanen Aila; Sovijärvi Anssi R; Piirilä Päivi; Naukkarinen Jussi; Peltonen Leena; Kaprio Jaakko; Yki-Järvinen Hannele
Acquired obesity and poor physical fitness impair expression of genes of mitochondrial oxidative phosphorylation in monozygotic twins discordant for obesity.
American journal of physiology. Endocrinology and metabolism 2008;295(1):E148-54.
2008: Sevastianova Ksenia; Sutinen Jussi; Kannisto Katja; Hamsten Anders; Ristola Matti; Yki-Järvinen Hannele
Adipose tissue inflammation and liver fat in patients with highly active antiretroviral therapy-associated lipodystrophy.
American journal of physiology. Endocrinology and metabolism 2008;295(1):E85-91.
2008: Greco Dario; Kotronen Anna; Westerbacka Jukka; Puig Oscar; Arkkila Perttu; Kiviluoto Tuula; Laitinen Saara; Kolak Maria; Fisher Rachel M; Hamsten Anders; Auvinen Petri; Yki-Järvinen Hannele
Gene expression in human NAFLD.
American journal of physiology. Gastrointestinal and liver physiology 2008;294(5):G1281-7.
2008: Westerbacka Jukka; Cornér Anja; Kolak Maria; Makkonen Janne; Turpeinen Ursula; Hamsten Anders; Fisher Rachel M; Yki-Järvinen Hannele
Insulin regulation of MCP-1 in human adipose tissue of obese and lean women.
American journal of physiology. Endocrinology and metabolism 2008;294(5):E841-5.
2008: Pietiläinen Kirsi H; Naukkarinen Jussi; Rissanen Aila; Saharinen Juha; Ellonen Pekka; Keränen Heli; Suomalainen Anu; Götz Alexandra; Suortti Tapani; Yki-Järvinen Hannele; Oresic Matej; Kaprio Jaakko; Peltonen Leena
Global transcript profiles of fat in monozygotic twins discordant for BMI: pathways behind acquired obesity.
PLoS medicine 2008;5(3):e51.
2008: Pietiläinen Kirsi H; Kaprio Jaakko; Borg Patrik; Plasqui Guy; Yki-Järvinen Hannele; Kujala Urho M; Rose Richard J; Westerterp Klaas R; Rissanen Aila
Physical inactivity and obesity: a vicious circle.
Obesity (Silver Spring, Md.) 2008;16(2):409-14.
2008: Kotronen A; Seppälä-Lindroos A; Bergholm R; Yki-Järvinen H
Tissue specificity of insulin resistance in humans: fat in the liver rather than muscle is associated with features of the metabolic syndrome.
Diabetologia 2008;51(1):130-8.
2008: Juurinen Leena; Kotronen Anna; Granér Marit; Yki-Järvinen Hannele
Rosiglitazone reduces liver fat and insulin requirements and improves hepatic insulin sensitivity and glycemic control in patients with type 2 diabetes requiring high insulin doses.
The Journal of clinical endocrinology and metabolism 2008;93(1):118-24.
2008: Kotronen Anna; Juurinen Leena; Hakkarainen Antti; Westerbacka Jukka; Cornér Anja; Bergholm Robert; Yki-Järvinen Hannele
Liver fat is increased in type 2 diabetic patients and underestimated by serum alanine aminotransferase compared with equally obese nondiabetic subjects.
Diabetes care 2008;31(1):165-9.
2008: Kotronen Anna; Yki-Järvinen Hannele
Fatty liver: a novel component of the metabolic syndrome.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(1):27-38.
2007: Kotronen Anna; Vehkavaara Satu; Seppälä-Lindroos Anneli; Bergholm Robert; Yki-Järvinen Hannele
Effect of liver fat on insulin clearance.
American journal of physiology. Endocrinology and metabolism 2007;293(6):E1709-15.
2007: Westerbacka Jukka; Kolak Maria; Kiviluoto Tuula; Arkkila Perttu; Sirén Jukka; Hamsten Anders; Fisher Rachel M; Yki-Järvinen Hannele
Genes involved in fatty acid partitioning and binding, lipolysis, monocyte/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjects.
Diabetes 2007;56(11):2759-65.
2007: Makkonen J; Westerbacka J; Kolak M; Sutinen J; Cornér A; Hamsten A; Fisher R M; Yki-Järvinen H
Increased expression of the macrophage markers and of 11beta-HSD-1 in subcutaneous adipose tissue, but not in cultured monocyte-derived macrophages, is associated with liver fat in human obesity.
International journal of obesity (2005) 2007;31(10):1617-25.
2007: Kotronen Anna; Westerbacka Jukka; Bergholm Robert; Pietiläinen Kirsi H; Yki-Järvinen Hannele
Liver fat in the metabolic syndrome.
The Journal of clinical endocrinology and metabolism 2007;92(9):3490-7.
2007: Kolak Maria; Westerbacka Jukka; Velagapudi Vidya R; Wågsäter Dick; Yetukuri Laxman; Makkonen Janne; Rissanen Aila; Häkkinen Anna-Maija; Lindell Monica; Bergholm Robert; Hamsten Anders; Eriksson Per; Fisher Rachel M; Oresic Matej; Yki-Järvinen Hannele
Adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat content independent of obesity.
Diabetes 2007;56(8):1960-8.
2007: Matikainen Niina; Mänttäri Sakari; Westerbacka Jukka; Vehkavaara Satu; Lundbom Nina; Yki-Järvinen Hannele; Taskinen Marja-Riitta
Postprandial lipemia associates with liver fat content.
The Journal of clinical endocrinology and metabolism 2007;92(8):3052-9.
2007: Sysi-Aho Marko; Vehtari Aki; Velagapudi Vidya R; Westerbacka Jukka; Yetukuri Laxman; Bergholm Robert; Taskinen Marja-Riitta; Yki-Järvinen Hannele; Oresic Matej
Exploring the lipoprotein composition using Bayesian regression on serum lipidomic profiles.
Bioinformatics (Oxford, England) 2007;23(13):i519-28.
2007: Yki-Järvinen Hannele; Juurinen Leena; Alvarsson Michael; Bystedt Tord; Caldwell Ian; Davies Melanie; Lahdenperä Sanni; Nijpels Gil; Vähätalo Markku
Initiate Insulin by Aggressive Titration and Education (INITIATE): a randomized study to compare initiation of insulin combination therapy in type 2 diabetic patients individually and in groups.
Diabetes care 2007;30(6):1364-9.
2007: Juurinen Leena; Tiikkainen Mirja; Häkkinen Anna-Maija; Hakkarainen Antti; Yki-Järvinen Hannele
Effects of insulin therapy on liver fat content and hepatic insulin sensitivity in patients with type 2 diabetes.
American journal of physiology. Endocrinology and metabolism 2007;292(3):E829-35.
2007: Sutinen Jussi; Yki-Järvinen Hannele
Increased resting energy expenditure, fat oxidation, and food intake in patients with highly active antiretroviral therapy-associated lipodystrophy.
American journal of physiology. Endocrinology and metabolism 2007;292(3):E687-92.
2007: Kolak Maria; Yki-Järvinen Hannele; Kannisto Katja; Tiikkainen Mirja; Hamsten Anders; Eriksson Per; Fisher Rachel M
Effects of chronic rosiglitazone therapy on gene expression in human adipose tissue in vivo in patients with type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2007;92(2):720-4.
2007: Sutinen Jussi; Walker Ulrich A; Sevastianova Ksenia; Klinker Hartwig; Häkkinen Anna-Maija; Ristola Matti; Yki-Järvinen Hannele
Uridine supplementation for the treatment of antiretroviral therapy-associated lipoatrophy: a randomized, double-blind, placebo-controlled trial.
Antiviral therapy 2007;12(1):97-105.
2007: Pietiläinen Kirsi H; Sysi-Aho Marko; Rissanen Aila; Seppänen-Laakso Tuulikki; Yki-Järvinen Hannele; Kaprio Jaakko; Oresic Matej
Acquired obesity is associated with changes in the serum lipidomic profile independent of genetic effects - a monozygotic twin study.
PloS one 2007;2(2):e218.
2007: Yki-Järvinen Hannele; Westerbacka Jukka
Insulin resistance, arterial stiffness and wave reflection.
Advances in cardiology 2007;44():252-60.
2006: Pietiläinen Kirsi H; Kannisto Katja; Korsheninnikova Elena; Rissanen Aila; Kaprio Jaakko; Ehrenborg Ewa; Hamsten Anders; Yki-Järvinen Hannele
Acquired obesity increases CD68 and tumor necrosis factor-alpha and decreases adiponectin gene expression in adipose tissue: a study in monozygotic twins.
The Journal of clinical endocrinology and metabolism 2006;91(7):2776-81.
2006: Pietiläinen Kirsi H; Bergholm Robert; Rissanen Aila; Kaprio Jaakko; Häkkinen Anna-Maija; Sattar Naveed; Yki-Järvinen Hannele
Effects of acquired obesity on endothelial function in monozygotic twins.
Obesity (Silver Spring, Md.) 2006;14(5):826-37.
2006: Yki-Järvinen H; Kauppinen-Mäkelin R; Tiikkainen M; Vähätalo M; Virtamo H; Nikkilä K; Tulokas T; Hulme S; Hardy K; McNulty S; Hänninen J; Levänen H; Lahdenperä S; Lehtonen R; Ryysy L
Insulin glargine or NPH combined with metformin in type 2 diabetes: the LANMET study.
Diabetologia 2006;49(3):442-51.
2006: Westerbacka J; Cornér A; Kannisto K; Kolak M; Makkonen J; Korsheninnikova E; Nyman T; Hamsten A; Fisher R M; Yki-Järvinen H
Acute in vivo effects of insulin on gene expression in adipose tissue in insulin-resistant and insulin-sensitive subjects.
Diabetologia 2006;49(1):132-40.
2006: Frayn Keith N; Arner Peter; Yki-Järvinen Hannele
Fatty acid metabolism in adipose tissue, muscle and liver in health and disease.
Essays in biochemistry 2006;42():89-103.
2005: Yki-Järvinen Hannele
The PROactive study: some answers, many questions.
Lancet 2005;366(9493):1241-2.
2005: Westerbacka J; Leinonen E; Salonen J T; Salonen R; Hiukka A; Yki-Järvinen H; Taskinen M-R
Increased augmentation of central blood pressure is associated with increases in carotid intima-media thickness in type 2 diabetic patients.
Diabetologia 2005;48(8):1654-62.
2005: Yki-Järvinen H; Westerbacka J
The fatty liver and insulin resistance.
Current molecular medicine 2005;5(3):287-95.
2005: Andrew Ruth; Westerbacka Jukka; Wahren John; Yki-Järvinen Hannele; Walker Brian R
The contribution of visceral adipose tissue to splanchnic cortisol production in healthy humans.
Diabetes 2005;54(5):1364-70.
2005: Seppälä Markku; Mandelin Erik; Koistinen Riitta; Bergholm Robert; Tiikkainen Mirja; Yki-Järvinen Hannele
Glycodelin responses to hyperinsulinaemic clamp vary according to basal serum glycodelin concentration.
Clinical endocrinology 2005;62(5):611-5.
2005: Westerbacka Jukka; Lammi Katriina; Häkkinen Anna-Maija; Rissanen Aila; Salminen Irma; Aro Antti; Yki-Järvinen Hannele
Dietary fat content modifies liver fat in overweight nondiabetic subjects.
The Journal of clinical endocrinology and metabolism 2005;90(5):2804-9.
2005: Pietiläinen Kirsi Hannele; Rissanen Aila; Kaprio Jaakko; Mäkimattila Sari; Häkkinen Anna-Maija; Westerbacka Jukka; Sutinen Jussi; Vehkavaara Satu; Yki-Järvinen Hannele
Acquired obesity is associated with increased liver fat, intra-abdominal fat, and insulin resistance in young adult monozygotic twins.
American journal of physiology. Endocrinology and metabolism 2005;288(4):E768-74.
2005: Janka Hans U; Plewe Gerd; Riddle Matthew C; Kliebe-Frisch Christine; Schweitzer Matthias A; Yki-Järvinen Hannele
Comparison of basal insulin added to oral agents versus twice-daily premixed insulin as initial insulin therapy for type 2 diabetes.
Diabetes care 2005;28(2):254-9.
2005: Sevastianova Ksenia; Sutinen Jussi; Westerbacka Jukka; Ristola Matti; Yki-Järvinen Hannele
Arterial stiffness in HIV-infected patients receiving highly active antiretroviral therapy.
Antiviral therapy 2005;10(8):925-35.
2005: Yki-Järvinen Hannele
Fat in the liver and insulin resistance.
Annals of medicine 2005;37(5):347-56.
2004: Mäkimattila Sari; Malmberg-Cèder Kirsi; Häkkinen Anna-Maija; Vuori Kim; Salonen Oili; Summanen Paula; Yki-Järvinen Hannele; Kaste Markku; Heikkinen Sami; Lundbom Nina; Roine Risto O
Brain metabolic alterations in patients with type 1 diabetes-hyperglycemia-induced injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2004;24(12):1393-9.
2004: Pietiläinen Kirsi H; Rissanen Aila; Laamanen Maria; Lindholm Anna-Kaisa; Markkula Harri; Yki-Järvinen Hannele; Kaprio Jaakko
Growth patterns in young adult monozygotic twin pairs discordant and concordant for obesity.
Twin research : the official journal of the International Society for Twin Studies 2004;7(5):421-9.
2004: Sutinen J; Kannisto K; Korsheninnikova E; Nyman T; Ehrenborg E; Andrew R; Wake D J; Hamsten A; Walker B R; Yki-Järvinen H
In the lipodystrophy associated with highly active antiretroviral therapy, pseudo-Cushing's syndrome is associated with increased regeneration of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue.
Diabetologia 2004;47(10):1668-71.
2004: Yki-Järvinen Hannele
Thiazolidinediones.
The New England journal of medicine 2004;351(11):1106-18.
2004: Kannisto Katja; Pietiläinen Kirsi H; Ehrenborg Ewa; Rissanen Aila; Kaprio Jaakko; Hamsten Anders; Yki-Järvinen Hannele
Overexpression of 11beta-hydroxysteroid dehydrogenase-1 in adipose tissue is associated with acquired obesity and features of insulin resistance: studies in young adult monozygotic twins.
The Journal of clinical endocrinology and metabolism 2004;89(9):4414-21.
2004: Westerbacka J; Cornér A; Tiikkainen M; Tamminen M; Vehkavaara S; Häkkinen A-M; Fredriksson J; Yki-Järvinen H
Women and men have similar amounts of liver and intra-abdominal fat, despite more subcutaneous fat in women: implications for sex differences in markers of cardiovascular risk.
Diabetologia 2004;47(8):1360-9.
2004: Tiikkainen Mirja; Häkkinen Anna-Maija; Korsheninnikova Elena; Nyman Tuulikki; Mäkimattila Sari; Yki-Järvinen Hannele
Effects of rosiglitazone and metformin on liver fat content, hepatic insulin resistance, insulin clearance, and gene expression in adipose tissue in patients with type 2 diabetes.
Diabetes 2004;53(8):2169-76.
2004: Yki-Järvinen H
Insulin therapy in type 2 diabetes: role of the long-acting insulin glargine analogue.
European journal of clinical investigation 2004;34(6):410-6.
2004: Gertow K; Pietiläinen K H; Yki-Järvinen H; Kaprio J; Rissanen A; Eriksson P; Hamsten A; Fisher R M
Expression of fatty-acid-handling proteins in human adipose tissue in relation to obesity and insulin resistance.
Diabetologia 2004;47(6):1118-25.
2004: Sutinen Jussi; Kannisto Katja; Korsheninnikova Elena; Fisher Rachel M; Ehrenborg Ewa; Nyman Tuulikki; Virkamäki Antti; Funahashi Tohru; Matsuzawa Yuji; Vidal Hubert; Hamsten Anders; Yki-Järvinen Hannele
Effects of rosiglitazone on gene expression in subcutaneous adipose tissue in highly active antiretroviral therapy-associated lipodystrophy.
American journal of physiology. Endocrinology and metabolism 2004;286(6):E941-9.
2004: Vehkavaara Satu; Yki-Järvinen Hannele
3.5 years of insulin therapy with insulin glargine improves in vivo endothelial function in type 2 diabetes.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(2):325-30.
2004: Westerbacka Jukka; Bergholm Robert; Tiikkainen Mirja; Yki-Järvinen Hannele
Glargine and regular human insulin similarly acutely enhance endothelium-dependent vasodilatation in normal subjects.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(2):320-4.
2004: Westerbacka J; Tamminen M; Cockcroft J; Yki-Järvinen H
Comparison of in vivo effects of nitroglycerin and insulin on the aortic pressure waveform.
European journal of clinical investigation 2004;34(1):1-8.
2004: Tiikkainen Mirja; Bergholm Robert; Rissanen Aila; Aro Antti; Salminen Irma; Tamminen Marjo; Teramo Kari; Yki-Järvinen Hannele
Effects of equal weight loss with orlistat and placebo on body fat and serum fatty acid composition and insulin resistance in obese women.
The American journal of clinical nutrition 2004;79(1):22-30.
2003: Westerbacka Jukka; Yki-Järvinen Hannele; Vehkavaara Satu; Häkkinen Anna-Maija; Andrew Ruth; Wake Deborah J; Seckl Jonathan R; Walker Brian R
Body fat distribution and cortisol metabolism in healthy men: enhanced 5beta-reductase and lower cortisol/cortisone metabolite ratios in men with fatty liver.
The Journal of clinical endocrinology and metabolism 2003;88(10):4924-31.
2003: Tamminen M K; Westerbacka J; Vehkavaara S; Yki-Järvinen H
Insulin therapy improves insulin actions on glucose metabolism and aortic wave reflection in type 2 diabetic patients.
European journal of clinical investigation 2003;33(10):855-60.
2003: Yki-Järvinen Hannele
Insulin resistance and endothelial dysfunction.
Best practice & research. Clinical endocrinology & metabolism 2003;17(3):411-30.
2003: Kannisto Katja; Sutinen Jussi; Korsheninnikova Elena; Fisher Rachel M; Ehrenborg Ewa; Gertow Karl; Virkamäki Antti; Nyman Tuulikki; Vidal Hubert; Hamsten Anders; Yki-Järvinen Hannele
Expression of adipogenic transcription factors, peroxisome proliferator-activated receptor gamma co-activator 1, IL-6 and CD45 in subcutaneous adipose tissue in lipodystrophy associated with highly active antiretroviral therapy.
AIDS (London, England) 2003;17(12):1753-62.
2003: Tamminen M; Lassila R; Westerbacka J; Vehkavaara S; Yki-Järvinen H
Obesity is associated with impaired platelet-inhibitory effect of acetylsalicylic acid in nondiabetic subjects.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2003;27(8):907-11.
2003: Yki-Järvinen H; Bergholm R; Leirisalo-Repo M
Increased inflammatory activity parallels increased basal nitric oxide production and blunted response to nitric oxide in vivo in rheumatoid arthritis.
Annals of the rheumatic diseases 2003;62(7):630-4.
2003: Sutinen Jussi; Häkkinen Anna-Maija; Westerbacka Jukka; Seppälä-Lindroos Anneli; Vehkavaara Satu; Halavaara Juha; Järvinen Asko; Ristola Matti; Yki-Järvinen Hannele
Rosiglitazone in the treatment of HAART-associated lipodystrophy--a randomized double-blind placebo-controlled study.
Antiviral therapy 2003;8(3):199-207.
2003: Alagona C; Soro A; Westerbacka J; Ylitalo K; Salonen J T; Salonen R; Yki-Järvinen H; Taskinen M-R
Low HDL cholesterol concentration is associated with increased intima-media thickness independent of arterial stiffness in healthy subjects from families with low HDL cholesterol.
European journal of clinical investigation 2003;33(6):457-63.
2003: Bergholm Robert; Tiikkainen Mirja; Vehkavaara Satu; Tamminen Marjo; Teramo Kari; Rissanen Aila; Yki-Järvinen Hannele
Lowering of LDL cholesterol rather than moderate weight loss improves endothelium-dependent vasodilatation in obese women with previous gestational diabetes.
Diabetes care 2003;26(6):1667-72.
2003: Sutinen Jussi; Korsheninnikova Elena; Funahashi Tohru; Matsuzawa Yuji; Nyman Tuulikki; Yki-Järvinen Hannele
Circulating concentration of adiponectin and its expression in subcutaneous adipose tissue in patients with highly active antiretroviral therapy-associated lipodystrophy.
The Journal of clinical endocrinology and metabolism 2003;88(4):1907-10.
2003: Yki-Järvinen Hannele; Sutinen Jussi; Silveira Angela; Korsheninnikova Elena; Fisher Rachel M; Kannisto Katja; Ehrenborg Ewa; Eriksson Per; Hamsten Anders
Regulation of plasma PAI-1 concentrations in HAART-associated lipodystrophy during rosiglitazone therapy.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(4):688-94.
2003: Tiikkainen Mirja; Bergholm Robert; Vehkavaara Satu; Rissanen Aila; Häkkinen Anna-Maija; Tamminen Marjo; Teramo Kari; Yki-Järvinen Hannele
Effects of identical weight loss on body composition and features of insulin resistance in obese women with high and low liver fat content.
Diabetes 2003;52(3):701-7.
2003: Hällsten Kirsti; Yki-Järvinen Hannele; Peltoniemi Pauliina; Oikonen Vesa; Takala Teemu; Kemppainen Jukka; Laine Hanna; Bergman Jörgen; Bolli Geremia B; Knuuti Juhani; Nuutila Pirjo
Insulin- and exercise-stimulated skeletal muscle blood flow and glucose uptake in obese men.
Obesity research 2003;11(2):257-65.
2003: Vihma Veera; Vehkavaara Satu; Yki-Järvinen Hannele; Hohtari Hannele; Tikkanen Matti J
Differential effects of oral and transdermal estradiol treatment on circulating estradiol fatty acid ester concentrations in postmenopausal women.
The Journal of clinical endocrinology and metabolism 2003;88(2):588-93.
2003: Yki-Järvinen Hannele
Nonglycemic effects of insulin.
Clinical cornerstone 2003;Suppl 4():S6-12.
2003: Yki-Järvinen Hannele
Insulin therapy and cardiovascular risk. Introduction.
Clinical cornerstone 2003;Suppl 4():S5.
2002: Tamminen Marjo; Westerbacka Jukka; Vehkavaara Satu; Yki-Järvinen Hannele
Insulin-induced decreases in aortic wave reflection and central systolic pressure are impaired in type 2 diabetes.
Diabetes care 2002;25(12):2314-9.
2002: Sutinen Jussi; Häkkinen Anna-Maija; Westerbacka Jukka; Seppälä-Lindroos Anneli; Vehkavaara Satu; Halavaara Juha; Järvinen Asko; Ristola Matti; Yki-Järvinen Hannele
Increased fat accumulation in the liver in HIV-infected patients with antiretroviral therapy-associated lipodystrophy.
AIDS (London, England) 2002;16(16):2183-93.
2002: Bergholm Robert; Leirisalo-Repo Marjatta; Vehkavaara Satu; Mäkimattila Sari; Taskinen Marja-Riitta; Yki-Järvinen Hannele
Impaired responsiveness to NO in newly diagnosed patients with rheumatoid arthritis.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(10):1637-41.
2002: Yki-Järvinen Hannele
Combination therapy with insulin and oral agents: optimizing glycemic control in patients with type 2 diabetes mellitus.
Diabetes/metabolism research and reviews 2002;18 Suppl 3():S77-81.
2002: Tiikkainen Mirja; Tamminen Marjo; Häkkinen Anna-Maija; Bergholm Robert; Vehkavaara Satu; Halavaara Juha; Teramo Kari; Rissanen Aila; Yki-Järvinen Hannele
Liver-fat accumulation and insulin resistance in obese women with previous gestational diabetes.
Obesity research 2002;10(9):859-67.
2002: Seppälä-Lindroos Anneli; Vehkavaara Satu; Häkkinen Anna-Maija; Goto Takashi; Westerbacka Jukka; Sovijärvi Anssi; Halavaara Juha; Yki-Järvinen Hannele
Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men.
The Journal of clinical endocrinology and metabolism 2002;87(7):3023-8.
2002: Westerbacka Jukka; Yki-Järvinen Hannele
Arterial stiffness and insulin resistance.
Seminars in vascular medicine 2002;2(2):157-64.
2002: Mäkimattila S; Ylitalo K; Schlenzka A; Taskinen M-R; Summanen P; Syvänne M; Yki-Järvinen H
Family histories of Type II diabetes and hypertension predict intima-media thickness in patients with Type I diabetes.
Diabetologia 2002;45(5):711-8.
2002: Mäkimattila Sari; Yki-Järvinen Hannele
Endothelial dysfunction in human diabetes.
Current diabetes reports 2002;2(1):26-36.
2002: Westerbacka Jukka; Yki-Järvinen Hannele; Turpeinen Anu; Rissanen Aila; Vehkavaara Satu; Syrjälä Martti; Lassila Riitta
Inhibition of platelet-collagen interaction: an in vivo action of insulin abolished by insulin resistance in obesity.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(1):167-72.
2002: Yki-Järvinen Hannele
Ectopic fat accumulation: an important cause of insulin resistance in humans.
Journal of the Royal Society of Medicine 2002;95 Suppl 42():39-45.
2001: Peltoniemi P; Yki-Järvinen H; Laine H; Oikonen V; Rönnemaa T; Kalliokoski K; Raitakari O; Knuuti M J; Nuutila P
Evidence for spatial heterogeneity in insulin- and exercise-induced increases in glucose uptake: studies in normal subjects and patients with type 1 diabetes.
The Journal of clinical endocrinology and metabolism 2001;86(11):5525-33.
2001: Westerbacka J; Seppälä-Lindroos A; Yki-Järvinen H
Resistance to acute insulin induced decreases in large artery stiffness accompanies the insulin resistance syndrome.
The Journal of clinical endocrinology and metabolism 2001;86(11):5262-8.
2001: Virkamäki A; Korsheninnikova E; Seppälä-Lindroos A; Vehkavaara S; Goto T; Halavaara J; Häkkinen A M; Yki-Järvinen H
Intramyocellular lipid is associated with resistance to in vivo insulin actions on glucose uptake, antilipolysis, and early insulin signaling pathways in human skeletal muscle.
Diabetes 2001;50(10):2337-43.
2001: Mäkimattila S; Hietaniemi K; Kiviluoto T; Timonen T; Yki-Järvinen H
In vivo glucose-stimulated amylin secretion is increased in nondiabetic patients with pancreatic cancer.
Metabolism: clinical and experimental 2001;50(9):1036-42.
2001: Peltoniemi P; Yki-Järvinen H; Oikonen V; Oksanen A; Takala T O; Rönnemaa T; Erkinjuntti M; Knuuti M J; Nuutila P
Resistance to exercise-induced increase in glucose uptake during hyperinsulinemia in insulin-resistant skeletal muscle of patients with type 1 diabetes.
Diabetes 2001;50(6):1371-7.
2001: Vehkavaara S; Silveira A; Hakala-Ala-Pietilä T; Virkamäki A; Hovatta O; Hamsten A; Taskinen M R; Yki-Järvinen H
Effects of oral and transdermal estrogen replacement therapy on markers of coagulation, fibrinolysis, inflammation and serum lipids and lipoproteins in postmenopausal women.
Thrombosis and haemostasis 2001;85(4):619-25.
2001: Yki-Järvinen H
Combination therapies with insulin in type 2 diabetes.
Diabetes care 2001;24(4):758-67.
2001: Ryysy L; Yki-Järvinen H
Improvement of glycemic control by 1 year of insulin therapy leads to a sustained decrease in sE-selectin concentrations in type 2 diabetes.
Diabetes care 2001;24(3):549-54.
2001: Bergholm R; Westerbacka J; Vehkavaara S; Seppälä-Lindroos A; Goto T; Yki-Järvinen H
Insulin sensitivity regulates autonomic control of heart rate variation independent of body weight in normal subjects.
The Journal of clinical endocrinology and metabolism 2001;86(3):1403-9.
2000: Vehkavaara S; Westerbacka J; Hakala-Ala-Pietilä T; Virkamäki A; Hovatta O; Yki-Järvinen H
Effect of estrogen replacement therapy on insulin sensitivity of glucose metabolism and preresistance and resistance vessel function in healthy postmenopausal women.
The Journal of clinical endocrinology and metabolism 2000;85(12):4663-70.
2000: Yki-Järvinen H
Management of type 2 diabetes mellitus and cardiovascular risk: lessons from intervention trials.
Drugs 2000;60(5):975-83.
2000: Vehkavaara S; Hakala-Ala-Pietilä T; Virkamäki A; Bergholm R; Ehnholm C; Hovatta O; Taskinen M R; Yki-Järvinen H
Differential effects of oral and transdermal estrogen replacement therapy on endothelial function in postmenopausal women.
Circulation 2000;102(22):2687-93.
2000: Mäkimattila S; Schlenzka A; Mäntysaari M; Bergholm R; Summanen P; Saar P; Erkkilä H; Yki-Järvinen H
Predictors of abnormal cardiovascular autonomic function measured by frequence domain analysis of heart rate variability and conventional tests in patients with type 1 diabetes.
Diabetes care 2000;23(11):1686-93.
2000: Mäkimattila S; Fineman M S; Yki-Järvinen H
Deficiency of total and nonglycosylated amylin in plasma characterizes subjects with impaired glucose tolerance and type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2000;85(8):2822-7.
2000: Vakkilainen J; Mäkimattila S; Seppälä-Lindroos A; Vehkavaara S; Lahdenperä S; Groop P H; Taskinen M R; Yki-Järvinen H
Endothelial dysfunction in men with small LDL particles.
Circulation 2000;102(7):716-21.
2000: Yki-Järvinen H; Dressler A; Ziemen M;
Less nocturnal hypoglycemia and better post-dinner glucose control with bedtime insulin glargine compared with bedtime NPH insulin during insulin combination therapy in type 2 diabetes. HOE 901/3002 Study Group.
Diabetes care 2000;23(8):1130-6.
2000: Yki-Järvinen H
A simple therapeutic combination for type 2 diabetes.
Hospital practice (1995) 2000;35(7):63-6, 72-4.
2000: Nuutila P; Peltoniemi P; Oikonen V; Larmola K; Kemppainen J; Takala T; Sipilä H; Oksanen A; Ruotsalainen U; Bolli G B; Yki-Järvinen H
Enhanced stimulation of glucose uptake by insulin increases exercise-stimulated glucose uptake in skeletal muscle in humans: studies using [15O]O2, [15O]H2O, [18F]fluoro-deoxy-glucose, and positron emission tomography.
Diabetes 2000;49(7):1084-91.
2000: Utriainen T; Lovisatti S; Mäkimattila S; Bertoldo A; Weintraub S; DeFronzo R; Cobelli C; Yki-Järvinen H
Direct measurement of the lumped constant for 2-deoxy-[1-(14)C]glucose in vivo in human skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2000;279(1):E228-33.
2000: Yki-Järvinen H; Westerbacka J
Vascular actions of insulin in obesity.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2000;24 Suppl 2():S25-8.
2000: Vogt C; Ardehali H; Iozzo P; Yki-Järvinen H; Koval J; Maezono K; Pendergrass M; Printz R; Granner D; DeFronzo R; Mandarino L
Regulation of hexokinase II expression in human skeletal muscle in vivo.
Metabolism: clinical and experimental 2000;49(6):814-8.
2000: Ryysy L; Häkkinen A M; Goto T; Vehkavaara S; Westerbacka J; Halavaara J; Yki-Järvinen H
Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients.
Diabetes 2000;49(5):749-58.
2000: Westerbacka J; Uosukainen A; Mäkimattila S; Schlenzka A; Yki-Järvinen H
Insulin-induced decrease in large artery stiffness is impaired in uncomplicated type 1 diabetes mellitus.
Hypertension 2000;35(5):1043-8.
2000: Vehkavaara S; Mäkimattila S; Schlenzka A; Vakkilainen J; Westerbacka J; Yki-Järvinen H
Insulin therapy improves endothelial function in type 2 diabetes.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(2):545-50.
1999: Laine H; Katoh C; Luotolahti M; Yki-Järvinen H; Kantola I; Jula A; Takala T O; Ruotsalainen U; Iida H; Haaparanta M; Nuutila P; Knuuti J
Myocardial oxygen consumption is unchanged but efficiency is reduced in patients with essential hypertension and left ventricular hypertrophy.
Circulation 1999;100(24):2425-30.
1999: Vehkavaara S; Seppälä-Lindroos A; Westerbacka J; Groop P H; Yki-Järvinen H
In vivo endothelial dysfunction characterizes patients with impaired fasting glucose.
Diabetes care 1999;22(12):2055-60.
1999: Mäkimattila S; Luoma J S; Ylä-Herttuala S; Bergholm R; Utriainen T; Virkamäki A; Mäntysaari M; Summanen P; Yki-Järvinen H
Autoantibodies against oxidized LDL and endothelium-dependent vasodilation in insulin-dependent diabetes mellitus.
Atherosclerosis 1999;147(1):115-22.
1999: Mero N; Suurinkeroinen L; Syvänne M; Knudsen P; Yki-Järvinen H; Taskinen M R
Delayed clearance of postprandial large TG-rich particles in normolipidemic carriers of LPL Asn291Ser gene variant.
Journal of lipid research 1999;40(9):1663-70.
1999: Bergholm R; Mäkimattila S; Valkonen M; Liu M L; Lahdenperä S; Taskinen M R; Sovijärvi A; Malmberg P; Yki-Järvinen H
Intense physical training decreases circulating antioxidants and endothelium-dependent vasodilatation in vivo.
Atherosclerosis 1999;145(2):341-9.
1999: Mäkimattila S; Liu M L; Vakkilainen J; Schlenzka A; Lahdenperä S; Syvänne M; Mäntysaari M; Summanen P; Bergholm R; Taskinen M R; Yki-Järvinen H
Impaired endothelium-dependent vasodilation in type 2 diabetes. Relation to LDL size, oxidized LDL, and antioxidants.
Diabetes care 1999;22(6):973-81.
1999: Liu M L; Bergholm R; Mäkimattila S; Lahdenperä S; Valkonen M; Hilden H; Yki-Järvinen H; Taskinen M R
A marathon run increases the susceptibility of LDL to oxidation in vitro and modifies plasma antioxidants.
The American journal of physiology 1999;276(6 Pt 1):E1083-91.
1999: Mäkimattila S; Nikkilä K; Yki-Järvinen H
Causes of weight gain during insulin therapy with and without metformin in patients with Type II diabetes mellitus.
Diabetologia 1999;42(4):406-12.
1999: Takala T O; Nuutila P; Knuuti J; Luotolahti M; Yki-Järvinen H
Insulin action on heart and skeletal muscle glucose uptake in weight lifters and endurance athletes.
The American journal of physiology 1999;276(4 Pt 1):E706-11.
1999: Westerbacka J; Vehkavaara S; Bergholm R; Wilkinson I; Cockcroft J; Yki-Järvinen H
Marked resistance of the ability of insulin to decrease arterial stiffness characterizes human obesity.
Diabetes 1999;48(4):821-7.
1999: Yki-Järvinen H; Ryysy L; Nikkilä K; Tulokas T; Vanamo R; Heikkilä M
Comparison of bedtime insulin regimens in patients with type 2 diabetes mellitus. A randomized, controlled trial.
Annals of internal medicine 1999;130(5):389-96.
1999: Yki-Järvinen H; Nikkilä K; Mäkimattila S
Metformin prevents weight gain by reducing dietary intake during insulin therapy in patients with type 2 diabetes mellitus.
Drugs 1999;58 Suppl 1():53-4; discussion 75-82.
1999: Yki-Järvinen H; Nyman T; Rissanen E; Leino M; Hämäläinen S; Virkamäki A; Hauguel-de Mouzon S
Glutamine: fructose-6-phosphate amidotransferase activity and gene expression are regulated in a tissue-specific fashion in pregnant rats.
Life sciences 1999;65(2):215-23.
1998: Yki-Järvinen H
Toxicity of hyperglycaemia in type 2 diabetes.
Diabetes/metabolism reviews 1998;14 Suppl 1():S45-50.
1998: Mäkimattila S; Summanen P; Matinlauri I; Mäntysaari M; Schlenzka A; Aalto M; Irjala K; Yki-Järvinen H
Serum total renin, an independent marker of the activity and severity of retinopathy in patients with IDDM.
The British journal of ophthalmology 1998;82(8):939-44.
1998: Laine H; Knuuti M J; Ruotsalainen U; Utriainen T; Oikonen V; Raitakari M; Luotolahti M; Kirvelä O; Vicini P; Cobelli C; Nuutila P; Yki-Järvinen H
Preserved relative dispersion but blunted stimulation of mean flow, absolute dispersion, and blood volume by insulin in skeletal muscle of patients with essential hypertension.
Circulation 1998;97(21):2146-53.
1998: Utriainen T; Takala T; Luotolahti M; Rönnemaa T; Laine H; Ruotsalainen U; Haaparanta M; Nuutila P; Yki-Järvinen H
Insulin resistance characterizes glucose uptake in skeletal muscle but not in the heart in NIDDM.
Diabetologia 1998;41(5):555-9.
1998: Malmström R; Packard C J; Caslake M; Bedford D; Stewart P; Yki-Järvinen H; Shepherd J; Taskinen M R
Effects of insulin and acipimox on VLDL1 and VLDL2 apolipoprotein B production in normal subjects.
Diabetes 1998;47(5):779-87.
1998: Yki-Järvinen H; Utriainen T
Insulin-induced vasodilatation: physiology or pharmacology?
Diabetologia 1998;41(4):369-79.
1998: Yki-Järvinen H; Virkamäki A; Daniels M C; McClain D; Gottschalk W K
Insulin and glucosamine infusions increase O-linked N-acetyl-glucosamine in skeletal muscle proteins in vivo.
Metabolism: clinical and experimental 1998;47(4):449-55.
1998: Laine H; Knuuti M J; Ruotsalainen U; Raitakari M; Iida H; Kapanen J; Kirvelä O; Haaparanta M; Yki-Järvinen H; Nuutila P
Insulin resistance in essential hypertension is characterized by impaired insulin stimulation of blood flow in skeletal muscle.
Journal of hypertension 1998;16(2):211-9.
1998: Mäkimattila S; Mäntysaari M; Schlenzka A; Summanen P; Yki-Järvinen H
Mechanisms of altered hemodynamic and metabolic responses to insulin in patients with insulin-dependent diabetes mellitus and autonomic dysfunction.
The Journal of clinical endocrinology and metabolism 1998;83(2):468-75.
1998: Lommi J; Kupari M; Yki-Järvinen H
Free fatty acid kinetics and oxidation in congestive heart failure.
The American journal of cardiology 1998;81(1):45-50.
1997: Yki-Järvinen H; Ryysy L; Kauppila M; Kujansuu E; Lahti J; Marjanen T; Niskanen L; Rajala S; Salo S; Seppälä P; Tulokas T; Viikari J; Taskinen M R
Effect of obesity on the response to insulin therapy in noninsulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1997;82(12):4037-43.
1997: Raitakari M; Nuutila P; Knuuti J; Raitakari O T; Laine H; Ruotsalainen U; Kirvelä O; Takala T O; Iida H; Yki-Järvinen H
Effects of insulin on blood flow and volume in skeletal muscle of patients with IDDM: studies using [15O]H2O, [15O]CO, and positron emission tomography.
Diabetes 1997;46(12):2017-21.
1997: Vicini P; Bonadonna R C; Utriainen T; Nuutila P; Raitakari M; Yki-Järvinen H; Cobelli C
Estimation of blood flow heterogeneity distribution in human skeletal muscle from positron emission tomography data.
Annals of biomedical engineering 1997;25(5):906-10.
1997: Yki-Järvinen H
Acute and chronic effects of hyperglycaemia on glucose metabolism: implications for the development of new therapies.
Diabetic medicine : a journal of the British Diabetic Association 1997;14 Suppl 3():S32-7.
1997: Utriainen T; Nuutila P; Takala T; Vicini P; Ruotsalainen U; Rönnemaa T; Tolvanen T; Raitakari M; Haaparanta M; Kirvelä O; Cobelli C; Yki-Järvinen H
Intact insulin stimulation of skeletal muscle blood flow, its heterogeneity and redistribution, but not of glucose uptake in non-insulin-dependent diabetes mellitus.
The Journal of clinical investigation 1997;100(4):777-85.
1997: Malmström R; Packard C J; Watson T D; Rannikko S; Caslake M; Bedford D; Stewart P; Yki-Järvinen H; Shepherd J; Taskinen M R
Metabolic basis of hypotriglyceridemic effects of insulin in normal men.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(7):1454-64.
1997: Yki-Järvinen H; Mäkimattila S
Insulin resistance due to hyperglycaemia: an adaptation protecting insulin-sensitive tissues.
Diabetologia 1997;40 Suppl 2():S141-4.
1997: Virkamäki A; Rissanen E; Hämäläinen S; Utriainen T; Yki-Järvinen H
Incorporation of [3-3H]glucose and 2-[1-14C]deoxyglucose into glycogen in heart and skeletal muscle in vivo: implications for the quantitation of tissue glucose uptake.
Diabetes 1997;46(7):1106-10.
1997: Virkamäki A; Daniels M C; Hämäläinen S; Utriainen T; McClain D; Yki-Järvinen H
Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance in multiple insulin sensitive tissues.
Endocrinology 1997;138(6):2501-7.
1997: Malmström R; Packard C J; Caslake M; Bedford D; Stewart P; Yki-Järvinen H; Shepherd J; Taskinen M R
Defective regulation of triglyceride metabolism by insulin in the liver in NIDDM.
Diabetologia 1997;40(4):454-62.
1997: Yki-Järvinen H
MODY genes and mutations in hepatocyte nuclear factors.
Lancet 1997;349(9051):516-7.
1997: Mäkimattila S; Mäntysaari M; Groop P H; Summanen P; Virkamäki A; Schlenzka A; Fagerudd J; Yki-Järvinen H
Hyperreactivity to nitrovasodilators in forearm vasculature is related to autonomic dysfunction in insulin-dependent diabetes mellitus.
Circulation 1997;95(3):618-25.
1997: Yki-Järvinen H; Vogt C; Iozzo P; Pipek R; Daniels M C; Virkamäki A; Mäkimattila S; Mandarino L; DeFronzo R A; McClain D; Gottschalk W K
UDP-N-acetylglucosamine transferase and glutamine: fructose 6-phosphate amidotransferase activities in insulin-sensitive tissues.
Diabetologia 1997;40(1):76-81.
1996: Utriainen T; Mäkimattila S; Virkamäki A; Bergholm R; Yki-Järvinen H
Dissociation between insulin sensitivity of glucose uptake and endothelial function in normal subjects.
Diabetologia 1996;39(12):1477-82.
1996: Utriainen T; Mäkimattila S; Virkamäki A; Lindholm H; Sovijärvi A; Yki-Järvinen H
Physical fitness and endothelial function (nitric oxide synthesis) are independent determinants of insulin-stimulated blood flow in normal subjects.
The Journal of clinical endocrinology and metabolism 1996;81(12):4258-63.
1996: Raitakari M; Nuutila P; Ruotsalainen U; Laine H; Teräs M; Iida H; Mäkimattila S; Utriainen T; Oikonen V; Sipilä H; Haaparanta M; Solin O; Wegelius U; Knuuti J; Yki-Järvinen H
Evidence for dissociation of insulin stimulation of blood flow and glucose uptake in human skeletal muscle: studies using [15O]H2O, [18F]fluoro-2-deoxy-D-glucose, and positron emission tomography.
Diabetes 1996;45(11):1471-7.
1996: Raitakari M; Nuutila P; Ruotsalainen U; Teräs M; Eronen E; Laine H; Raitakari O T; Iida H; Knuuti M J; Yki-Järvinen H
Relationship between limb and muscle blood flow in man.
The Journal of physiology 1996;496 ( Pt 2)():543-9.
1996: Utriainen T; Malmström R; Mäkimattila S; Yki-Järvinen H
Supraphysiological hyperinsulinemia increases plasma leptin concentrations after 4 h in normal subjects.
Diabetes 1996;45(10):1364-6.
1996: Mäkimattila S; Virkamäki A; Groop P H; Cockcroft J; Utriainen T; Fagerudd J; Yki-Järvinen H
Chronic hyperglycemia impairs endothelial function and insulin sensitivity via different mechanisms in insulin-dependent diabetes mellitus.
Circulation 1996;94(6):1276-82.
1996: Malmström R; Taskinen M R; Karonen S L; Yki-Järvinen H
Insulin increases plasma leptin concentrations in normal subjects and patients with NIDDM.
Diabetologia 1996;39(8):993-6.
1996: Utriainen T; Holmäng A; Björntorp P; Mäkimattila S; Sovijärvi A; Lindholm H; Yki-Järvinen H
Physical fitness, muscle morphology, and insulin-stimulated limb blood flow in normal subjects.
The American journal of physiology 1996;270(5 Pt 1):E905-11.
1996: Nuutila P; Raitakari M; Laine H; Kirvelä O; Takala T; Utriainen T; Mäkimattila S; Pitkänen O P; Ruotsalainen U; Iida H; Knuuti J; Yki-Järvinen H
Role of blood flow in regulating insulin-stimulated glucose uptake in humans. Studies using bradykinin, [15O]water, and [18F]fluoro-deoxy-glucose and positron emission tomography.
The Journal of clinical investigation 1996;97(7):1741-7.
1996: Yki-Järvinen H; Daniels M C; Virkamäki A; Mäkimattila S; DeFronzo R A; McClain D
Increased glutamine:fructose-6-phosphate amidotransferase activity in skeletal muscle of patients with NIDDM.
Diabetes 1996;45(3):302-7.
1995: Yki-Järvinen H
Role of insulin resistance in the pathogenesis of NIDDM.
Diabetologia 1995;38(12):1378-88.
1995: Yki-Järvinen H; Mäkimattila S; Utriainen T; Rutanen E M
Portal insulin concentrations rather than insulin sensitivity regulate serum sex hormone-binding globulin and insulin-like growth factor binding protein 1 in vivo.
The Journal of clinical endocrinology and metabolism 1995;80(11):3227-32.
1995: Löfman M; Yki-Järvinen H; Parkkonen M; Lindström J; Koranyi L; Schalin-Jäntti C; Groop L
Increased concentrations of glycogen synthase protein in skeletal muscle of patients with NIDDM.
The American journal of physiology 1995;269(1 Pt 1):E27-32.
1995: Knuuti M J; Mäki M; Yki-Järvinen H; Voipio-Pulkki L M; Härkönen R; Haaparanta M; Nuutila P
The effect of insulin and FFA on myocardial glucose uptake.
Journal of molecular and cellular cardiology 1995;27(7):1359-67.
1995: Sane T; Knudsen P; Vuorinen-Markkola H; Yki-Järvinen H; Taskinen M R
Decreasing triglyceride by gemfibrozil therapy does not affect the glucoregulatory or antilipolytic effect of insulin in nondiabetic subjects with mild hypertriglyceridemia.
Metabolism: clinical and experimental 1995;44(5):589-96.
1995: Utriainen T; Malmström R; Mäkimattila S; Yki-Järvinen H
Methodological aspects, dose-response characteristics and causes of interindividual variation in insulin stimulation of limb blood flow in normal subjects.
Diabetologia 1995;38(5):555-64.
1995: Virkamäki A; Yki-Järvinen H
Role of prostaglandins in mediating alterations in glucose metabolism during acute endotoxemia in the rat.
Endocrinology 1995;136(4):1701-6.
1995: Kuusi T; Yki-Järvinen H; Kauppinen-Mäkelin R; Jauhiainen M; Ehnholm C; Kauppila M; Seppälä P; Viikari J; Kujansuu E; Rajala S
Effect of insulin treatment on serum lipoprotein(a) in non-insulin-dependent diabetes.
European journal of clinical investigation 1995;25(3):194-200.
1995: Vuorinen-Markkola H; Yki-Järvinen H
Antihypertensive therapy with enalapril improves glucose storage and insulin sensitivity in hypertensive patients with non-insulin-dependent diabetes mellitus.
Metabolism: clinical and experimental 1995;44(1):85-9.
1995: Puhakainen I; Ahola I; Yki-Järvinen H
Dietary supplementation with n-3 fatty acids increases gluconeogenesis from glycerol but not hepatic glucose production in patients with non-insulin-dependent diabetes mellitus.
The American journal of clinical nutrition 1995;61(1):121-6.
1995: Nuutila P; Knuuti M J; Mäki M; Laine H; Ruotsalainen U; Teräs M; Haaparanta M; Solin O; Yki-Järvinen H
Gender and insulin sensitivity in the heart and in skeletal muscles. Studies using positron emission tomography.
Diabetes 1995;44(1):31-6.
1994: Nuutila P; Knuuti M J; Raitakari M; Ruotsalainen U; Teräs M; Voipio-Pulkki L M; Haaparanta M; Solin O; Wegelius U; Yki-Järvinen H
Effect of antilipolysis on heart and skeletal muscle glucose uptake in overnight fasted humans.
The American journal of physiology 1994;267(6 Pt 1):E941-6.
1994: Puhakainen I; Taskinen M R; Yki-Järvinen H
Comparison of acute daytime and nocturnal insulinization on diurnal glucose homeostasis in NIDDM.
Diabetes care 1994;17(8):805-9.
1994: Knuuti M J; Yki-Järvinen H; Voipio-Pulkki L M; Mäki M; Ruotsalainen U; Härkönen R; Teräs M; Haaparanta M; Bergman J; Hartiala J
Enhancement of myocardial [fluorine-18]fluorodeoxyglucose uptake by a nicotinic acid derivative.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1994;35(6):989-98.
1994: Nuutila P; Knuuti M J; Heinonen O J; Ruotsalainen U; Teräs M; Bergman J; Solin O; Yki-Järvinen H; Voipio-Pulkki L M; Wegelius U
Different alterations in the insulin-stimulated glucose uptake in the athlete's heart and skeletal muscle.
The Journal of clinical investigation 1994;93(5):2267-74.
1994: Virkamäki A; Yki-Järvinen H
Mechanisms of insulin resistance during acute endotoxemia.
Endocrinology 1994;134(5):2072-8.
1994: Schalin-Jäntti C; Yki-Järvinen H; Koranyi L; Bourey R; Lindström J; Nikula-Ijäs P; Franssila-Kallunki A; Groop L C
Effect of insulin on GLUT-4 mRNA and protein concentrations in skeletal muscle of patients with NIDDM and their first-degree relatives.
Diabetologia 1994;37(4):401-7.
1993: Puhakainen I; Yki-Järvinen H
Inhibition of lipolysis decreases lipid oxidation and gluconeogenesis from lactate but not fasting hyperglycemia or total hepatic glucose production in NIDDM.
Diabetes 1993;42(12):1694-9.
1993: Rutanen E M; Kärkkäinen T; Stenman U H; Yki-Järvinen H
Aging is associated with decreased suppression of insulin-like growth factor binding protein-1 by insulin.
The Journal of clinical endocrinology and metabolism 1993;77(5):1152-5.
1993: Vuorinen-Markkola H; Yki-Järvinen H; Taskinen M R
Lowering of triglycerides by gemfibrozil affects neither the glucoregulatory nor antilipolytic effect of insulin in type 2 (non-insulin-dependent) diabetic patients.
Diabetologia 1993;36(2):161-9.
1993: Koivisto V A; Yki-Järvinen H
Fructose and insulin sensitivity in patients with type 2 diabetes.
Journal of internal medicine 1993;233(2):145-53.
1992: Yki-Järvinen H; Kauppila M; Kujansuu E; Lahti J; Marjanen T; Niskanen L; Rajala S; Ryysy L; Salo S; Seppälä P
Comparison of insulin regimens in patients with non-insulin-dependent diabetes mellitus.
The New England journal of medicine 1992;327(20):1426-33.
1992: Kubota M; Virkamäki A; Yki-Järvinen H
Ethanol stimulates glycogenolysis in livers from fed rats.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1992;201(1):114-8.
1992: Yki-Järvinen H; Vuorinen-Markkola H; Koranyi L; Bourey R; Tordjman K; Mueckler M; Permutt A M; Koivisto V A
Defect in insulin action on expression of the muscle/adipose tissue glucose transporter gene in skeletal muscle of type 1 diabetic patients.
The Journal of clinical endocrinology and metabolism 1992;75(3):795-9.
1992: Puhakainen I; Koivisto V A; Yki-Järvinen H
Lipolysis and gluconeogenesis from glycerol are increased in patients with noninsulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1992;75(3):789-94.
1992: Virkamäki A; Puhakainen I; Koivisto V A; Vuorinen-Markkola H; Yki-Järvinen H
Mechanisms of hepatic and peripheral insulin resistance during acute infections in humans.
The Journal of clinical endocrinology and metabolism 1992;74(3):673-9.
1992: Sane T; Helve E; Yki-Järvinen H; Taskinen M R
One-year response to evening insulin therapy in non-insulin-dependent diabetes.
Journal of internal medicine 1992;231(3):253-60.
1992: Vuorinen-Markkola H; Puhakainen I; Yki-Järvinen H
No evidence for short-term regulation of plasminogen activator inhibitor activity by insulin in man.
Thrombosis and haemostasis 1992;67(1):117-20.
1991: Koranyi L I; Bourey R E; Vuorinen-Markkola H; Koivisto V A; Mueckler M; Permutt M A; Yki-Järvinen H
Level of skeletal muscle glucose transporter protein correlates with insulin-stimulated whole body glucose disposal in man.
Diabetologia 1991;34(10):763-5.
1991: Puhakainen I; Koivisto V A; Yki-Järvinen H
No reduction in total hepatic glucose output by inhibition of gluconeogenesis with ethanol in NIDDM patients.
Diabetes 1991;40(10):1319-27.
1991: Yki-Järvinen H; Puhakainen I; Koivisto V A
Effect of free fatty acids on glucose uptake and nonoxidative glycolysis across human forearm tissues in the basal state and during insulin stimulation.
The Journal of clinical endocrinology and metabolism 1991;72(6):1268-77.
1991: Yki-Järvinen H; Puhakainen I; Saloranta C; Groop L; Taskinen M R
Demonstration of a novel feedback mechanism between FFA oxidation from intracellular and intravascular sources.
The American journal of physiology 1991;260(5 Pt 1):E680-9.
1990: Yki-Järvinen H
Acute and chronic effects of hyperglycaemia on glucose metabolism.
Diabetologia 1990;33(10):579-85.
1990: Virkamäki A; Puhakainen I; Nurjhan N; Gerich J E; Yki-Järvinen H
Measurement of lactate formation from glucose using [6-3H]- and [6-14C]glucose in humans.
The American journal of physiology 1990;259(3 Pt 1):E397-404.
1990: Koivisto V A; Yki-Järvinen H; Puhakainen I; Virkamäki A; Kolaczynski J; DeFronzo R
No evidence for isotope discrimination of tritiated glucose tracers in measurements of glucose turnover rates in man.
Diabetologia 1990;33(3):168-73.
1990: Yki-Järvinen H; Sahlin K; Ren J M; Koivisto V A
Localization of rate-limiting defect for glucose disposal in skeletal muscle of insulin-resistant type I diabetic patients.
Diabetes 1990;39(2):157-67.
1989: Yki-Järvinen H; Sammalkorpi K; Koivisto V A; Nikkilä E A
Severity, duration, and mechanisms of insulin resistance during acute infections.
The Journal of clinical endocrinology and metabolism 1989;69(2):317-23.
1989: Yki-Järvinen H; Helve E; Sane T; Nurjhan N; Taskinen M R
Insulin inhibition of overnight glucose production and gluconeogenesis from lactate in NIDDM.
The American journal of physiology 1989;256(6 Pt 1):E732-9.
1989: Taskinen M R; Sane T; Helve E; Karonen S L; Nikkilä E A; Yki-Järvinen H
Bedtime insulin for suppression of overnight free-fatty acid, blood glucose, and glucose production in NIDDM.
Diabetes 1989;38(5):580-8.
1989: Kuusi T; Nieminen M S; Ehnholm C; Yki-Järvinen H; Valle M; Nikkilä E A; Taskinen M R
Apoprotein E polymorphism and coronary artery disease. Increased prevalence of apolipoprotein E-4 in angiographically verified coronary patients.
Arteriosclerosis (Dallas, Tex.) 1989;9(2):237-41.
1989: Suikkari A M; Sane T; Seppälä M; Yki-Järvinen H; Karonen S L; Koivisto V A
Prolonged exercise increases serum insulin-like growth factor-binding protein concentrations.
The Journal of clinical endocrinology and metabolism 1989;68(1):141-4.
1989: Suikkari A M; Koivisto V A; Koistinen R; Seppälä M; Yki-Järvinen H
Dose-response characteristics for suppression of low molecular weight plasma insulin-like growth factor-binding protein by insulin.
The Journal of clinical endocrinology and metabolism 1989;68(1):135-40.
1988: Yki-Järvinen H; Taskinen M R
Interrelationships among insulin's antilipolytic and glucoregulatory effects and plasma triglycerides in nondiabetic and diabetic patients with endogenous hypertriglyceridemia.
Diabetes 1988;37(9):1271-8.
1988: Taskinen M R; Kuusi T; Yki-Järvinen H; Nikkilä E A
Short-term effects of prednisone on serum lipids and high density lipoprotein subfractions in normolipidemic healthy men.
The Journal of clinical endocrinology and metabolism 1988;67(2):291-9.
1988: Taskinen M R; Kuusi T; Helve E; Nikkilä E A; Yki-Järvinen H
Insulin therapy induces antiatherogenic changes of serum lipoproteins in noninsulin-dependent diabetes.
Arteriosclerosis (Dallas, Tex.) 1988;8(2):168-77.
1988: Yki-Järvinen H; Koivisto V A; Ylikahri R; Taskinen M R
Acute effects of ethanol and acetate on glucose kinetics in normal subjects.
The American journal of physiology 1988;254(2 Pt 1):E175-80.
1988: Yki-Järvinen H; Esko N; Eero H; Marja-Riitta T
Clinical benefits and mechanisms of a sustained response to intermittent insulin therapy in type 2 diabetic patients with secondary drug failure.
The American journal of medicine 1988;84(2):185-92.
1988: Suikkari A M; Koivisto V A; Rutanen E M; Yki-Järvinen H; Karonen S L; Seppälä M
Insulin regulates the serum levels of low molecular weight insulin-like growth factor-binding protein.
The Journal of clinical endocrinology and metabolism 1988;66(2):266-72.
1986: Koivisto V A; Yki-Järvinen H; Helve E; Karonen S L; Pelkonen R
Pathogenesis and prevention of the dawn phenomenon in diabetic patients treated with CSII.
Diabetes 1986;35(1):78-82.
1984: Yki-Järvinen H; Taskinen M R; Kiviluoto T; Hilden H; Helve E; Koivisto V A; Nikkilä E A
Site of insulin resistance in type 1 diabetes: insulin-mediated glucose disposal in vivo in relation to insulin binding and action in adipocytes in vitro.
The Journal of clinical endocrinology and metabolism 1984;59(6):1183-92.

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