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Seppo Yla-Herttuala

Research Profile

Procedures

Living Beings

Chemicals & Drugs

Physiology

Neovascularization, Physiologic

Anatomy

Disorders

Devices

Gene Transfer Techniques

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Publications

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Minna Sopo; Laura Tuppurainen; Pasi Tuunanen; Kari Alitalo; Maarit Anttila; Kirsi Hamalainen; Seppo Heinonen; Jonna K Koponen; Veli-Matti Kosma; Svetlana Laidinen; Anniina Laurema; Hanna Sallinen; Seppo Yla-Herttuala
Antiangiogenic gene therapy with soluble VEGF-receptors -1, -2 and -3 together with paclitaxel prolongs survival of mice with human ovarian carcinoma.
Kati Kinnunen; Seppo Yla-Herttuala
Gene therapy in age related macular degeneration and hereditary macular disorders.
Shalini Bhardwaj; Himadri Roy; Masabumi Shibuya; Mohan Babu; Seppo Yla-Herttuala
Adventitial gene transfer of VEGFR-2 specific VEGF-E chimera induces MCP-1 expression in vascular smooth muscle cells and enhances neointimal formation.

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All Publications

2012: Minna Sopo; Laura Tuppurainen; Pasi Tuunanen; Kari Alitalo; Maarit Anttila; Kirsi Hamalainen; Seppo Heinonen; Jonna K Koponen; Veli-Matti Kosma; Svetlana Laidinen; Anniina Laurema; Hanna Sallinen; Seppo Yla-Herttuala
Antiangiogenic gene therapy with soluble VEGF-receptors -1, -2 and -3 together with paclitaxel prolongs survival of mice with human ovarian carcinoma.
International journal of cancer. Journal international du cancer 2012;131(10):2394-401.
2012: Kati Kinnunen; Seppo Yla-Herttuala
Gene therapy in age related macular degeneration and hereditary macular disorders.
Frontiers in bioscience (Elite edition) 2012;4():2546-57.
2011: Shalini Bhardwaj; Himadri Roy; Masabumi Shibuya; Mohan Babu; Seppo Yla-Herttuala
Adventitial gene transfer of VEGFR-2 specific VEGF-E chimera induces MCP-1 expression in vascular smooth muscle cells and enhances neointimal formation.
Atherosclerosis 2011;219(1):84-91.
2010: Agnieszka Jazwa; Paulina Kucharzewska; Justyna Leja; Anna Zagorska; Aleksandra Sierpniowska; Jacek Stepniewski; Magdalena Kozakowska; Hevidar Taha; Takahiro Ochiya; Rafal Derlacz; Elisa Vahakangas; Seppo Yla-Herttuala; Alicja Jozkowicz; Jozef Dulak
Combined vascular endothelial growth factor-A and fibroblast growth factor 4 gene transfer improves wound healing in diabetic mice.
Genetic vaccines and therapy 2010;8():6.
2009: Agnieszka Loboda; Anna Stachurska; Urszula Florczyk; Dominika Rudnicka; Agnieszka Jazwa; Joanna Wegrzyn; Magdalena Kozakowska; Krystyna Stalinska; Lorenz Poellinger; Anna-Liisa Levonen; Seppo Yla-Herttuala; Alicja Jozkowicz; Jozef Dulak
HIF-1 induction attenuates Nrf2-dependent IL-8 expression in human endothelial cells.
Antioxidants & redox signaling 2009;11(7):1501-17.
2009: Gillian Langford; Anthony Dayan; Seppo Yla-Herttuala; David Eckland
A preclinical assessment of the safety and biodistribution of an adenoviral vector containing the herpes simplex virus thymidine kinase gene (Cerepro) after intracerebral administration.
The journal of gene medicine 2009;11(6):468-76.
2009: Himadri Roy; Shalini Bhardwaj; Seppo Yla-Herttuala
Molecular genetics of atherosclerosis.
Human genetics 2009;125(5-6):467-91.
2009: Fan Zhang; Zhongshu Tang; Xu Hou; Johan Lennartsson; Yang Li; Alexander W Koch; Pierre Scotney; Chunsik Lee; Pachiappan Arjunan; Lijin Dong; Anil Kumar; Tuomas T Rissanen; Bin Wang; Nobuo Nagai; Pierre Fons; Robert Fariss; Yongqing Zhang; Eric F Wawrousek; Ginger Tansey; James Raber; Guo-Hua Fong; Hao Ding; David A Greenberg; Kevin G Becker; Jean-Marc Herbert; Andrew Nash; Seppo Yla-Herttuala; Yihai Cao; Ryan J Watts; Xuri Li
VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(15):6152-7.
2009: Hanna Sallinen; Maarit Anttila; Johanna Narvainen; Jonna K Koponen; Kirsi Hamalainen; Ivana Kholova; Tommi Heikura; Pyry Toivanen; Veli-Matti Kosma; Seppo Heinonen; Kari Alitalo; Seppo Yla-Herttuala
Antiangiogenic gene therapy with soluble VEGFR-1, -2, and -3 reduces the growth of solid human ovarian carcinoma in mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(2):278-84.
2009: Franco Scaldaferri; Stefania Vetrano; Miquel Sans; Vincenzo Arena; Giuseppe Straface; Egidio Stigliano; Alessandro Repici; Andreas Sturm; Alberto Malesci; Julian Panes; Seppo Yla-Herttuala; Claudio Fiocchi; Silvio Danese
VEGF-A links angiogenesis and inflammation in inflammatory bowel disease pathogenesis.
Gastroenterology 2009;136(2):585-95.e5.
2008: Rafal Dworakowski; Dorota Dworakowska; Ivan Kocic; Tomas Wirth; Marcin Gruchała; Maciej Kamiński; Robin Ray; Jacek Petrusewicz; Seppo Yla-Herttuala; Andrzej Rynkiewicz
Experimental hyperlipidaemia does not prevent preconditioning and it reduces ischemia-induced apoptosis.
International journal of cardiology 2008;126(1):62-7.
2008: Nitin T Aggarwal; Yuttanna Chawengsub; Kathryn M Gauthier; Helena Viita; Seppo Yla-Herttuala; William B Campbell
Endothelial 15-lipoxygenase-1 overexpression increases acetylcholine-induced hypotension and vasorelaxation in rabbits.
Hypertension 2008;51(2):246-51.
2007: Salla Keskitalo; Tuomas Tammela; Johannes Lyytikka; Terhi Karpanen; Michael Jeltsch; Johanna E Markkanen; Seppo Yla-Herttuala; Kari Alitalo
Enhanced capillary formation stimulated by a chimeric vascular endothelial growth factor/vascular endothelial growth factor-C silk domain fusion protein.
Circulation research 2007;100(10):1460-7.
2007: Nitin T Aggarwal; Blythe B Holmes; Lijie Cui; Helena Viita; Seppo Yla-Herttuala; William B Campbell
Adenoviral expression of 15-lipoxygenase-1 in rabbit aortic endothelium: role in arachidonic acid-induced relaxation.
American journal of physiology. Heart and circulatory physiology 2007;292(2):H1033-41.
2007: Markus Lucerna; Alma Zernecke; Ramon de Nooijer; Saskia C A de Jager; Ilze Bot; Christian van der Lans; Ivana Kholova; Elisa A Liehn; Theo Van berkel; Seppo Yla-Herttuala; Christian Weber; Erik A L Biessen
Vascular endothelial growth factor-A induces plaque expansion in ApoE knock-out mice by promoting de novo leukocyte recruitment.
Blood 2007;109(1):122-9.
2006: Hanna Sallinen; Maarit Anttila; Johanna Narvainen; Maija-Riitta Ordén; Kirsi Ropponen; Veli-Matti Kosma; Seppo Heinonen; Seppo Yla-Herttuala
A highly reproducible xenograft model for human ovarian carcinoma and application of MRI and ultrasound in longitudinal follow-up.
Gynecologic oncology 2006;103(1):315-20.
2006: Anne Saaristo; Tuomas Tammela; Anniina Farkkilā; Marika Kärkkäinen; Erkki Suominen; Seppo Yla-Herttuala; Kari Alitalo
Vascular endothelial growth factor-C accelerates diabetic wound healing.
The American journal of pathology 2006;169(3):1080-7.
2005: Anne Saaristo; E Suominen; Seppo Yla-Herttuala
Gene transfer as a tool to induce therapeutic vascular growth in plastic surgery.
Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Mikrochirurgie der Peripheren Nerven und Gefässe : Organ der Vereinigung der Deutschen Plastischen Chirurgen 2005;37(6):375-82.
2005: Joseph C Wu; Seppo Yla-Herttuala
Human gene therapy and imaging: cardiology.
European journal of nuclear medicine and molecular imaging 2005;32 Suppl 2():S346-57.
2005: Kalevi Juhani Pulkkanen; Seppo Yla-Herttuala
Gene therapy for malignant glioma: current clinical status.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(4):585-98.
2005: Hanna L Puhakka; Päivi Turunen; Juha Rutanen; Mikko O Hiltunen; Mikko Turunen; Seppo Yla-Herttuala
Tissue inhibitor of metalloproteinase 1 adenoviral gene therapy alone is equally effective in reducing restenosis as combination gene therapy in a rabbit restenosis model.
Journal of vascular research 2005;42(5):361-7.
2005: Tuomas Tammela; Anne Saaristo; Marja Lohela; Tohru Morisada; Jenny Tornberg; Camilla Norrmén; Yuichi Oike; Katri Pajusola; Gavin Thurston; Toshio Suda; Seppo Yla-Herttuala; Kari Alitalo
Angiopoietin-1 promotes lymphatic sprouting and hyperplasia.
Blood 2005;105(12):4642-8.
2005: Peter W Radke; Uta Griesenbach; Antti Kivela; Terry Vick; Diane Judd; Felix M Munkonge; Sean Willis; Duncan M Geddes; Seppo Yla-Herttuala; Eric W F W Alton
Vascular oligonucleotide transfer facilitated by a polymer-coated stent.
Human gene therapy 2005;16(6):734-40.
2005: Yulong He; Iiro Rajantie; Katri Pajusola; Michael Jeltsch; Tanja Holopainen; Seppo Yla-Herttuala; Thomas C Harding; Karin Jooss; Takashi Takahashi; Kari Alitalo
Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels.
Cancer research 2005;65(11):4739-46.
2004: Anne Saaristo; Tuomas Tammela; Jari Timonen; Seppo Yla-Herttuala; Erkki Tukiainen; Sirpa Asko-Seljavaara; Kari Alitalo
Vascular endothelial growth factor-C gene therapy restores lymphatic flow across incision wounds.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(14):1707-9.
2004: Rohit Khurana; Zhenwu Zhuang; Shalini Bhardwaj; Masahiro Murakami; Ebo De Muinck; Seppo Yla-Herttuala; Napoleone Ferrara; John F Martin; Ian Zachary; Michael Simons
Angiogenesis-dependent and independent phases of intimal hyperplasia.
Circulation 2004;110(16):2436-43.
2003: Klaus Pels; Carolin Deiner; Sarah E Coupland; Michel Noutsias; Andreas P Sutter; Heinz-Peter Schultheiss; Seppo Yla-Herttuala; Peter L Schwimmbeck
Effect of adventitial VEGF(165) gene transfer on vascular thickening after coronary artery balloon injury.
Cardiovascular research 2003;60(3):664-72.
2003: Erika Iivanainen; Lassi Nelimarkka; Varpu Elenius; Satu-Maria Heikkinen; Teemu T Junttila; Laura Sihombing; Maria Sundvall; Jorma A Maatta; Jukka Laine; Seppo Yla-Herttuala; Shigeki Higashiyama; Kari Alitalo; Klaus Elenius
Angiopoietin-regulated recruitment of vascular smooth muscle cells by endothelial-derived heparin binding EGF-like growth factor.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(12):1609-21.
2003: Brigitte Allart; Pauliina Lehtolainen; Seppo Yla-Herttuala; John F Martin; David L Selwood
A stable bis-allyloxycarbonyl biotin aldehyde derivative for biotinylation via reductive alkylation: application to the synthesis of a biotinylated doxorubicin derivative.
Bioconjugate chemistry 2003;14(1):187-94.
2002: Kalevi Juhani Pulkkanen; Johanna M Laukkanen; Jonas Fuxe; Mikko I Kettunen; Marko Rehn; Jani M Kannasto; Jyrki Parkkinen; Risto A Kauppinen; Ralf F Pettersson; Seppo Yla-Herttuala
The combination of HSV-tk and endostatin gene therapy eradicates orthotopic human renal cell carcinomas in nude mice.
Cancer gene therapy 2002;9(11):908-16.
2002: Mikko O Laukkanen; Antti Kivelä; Tuomas T Rissanen; Juha Rutanen; Minna K Karkkainen; Olli Leppanen; Jan Hinrich Bräsen; Seppo Yla-Herttuala
Adenovirus-mediated extracellular superoxide dismutase gene therapy reduces neointima formation in balloon-denuded rabbit aorta.
Circulation 2002;106(15):1999-2003.
2002: Yulong He; Ken-Ichi Kozaki; Terhi Karpanen; Katsumi Koshikawa; Seppo Yla-Herttuala; Takashi Takahashi; Kari Alitalo
Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling.
Journal of the National Cancer Institute 2002;94(11):819-25.
2001: Marika J Karkkainen; Anne Saaristo; Lotta Jussila; K A Karila; Elizabeth Lawrence; Katri Pajusola; Hansruedi Bueler; Anne Eichmann; Raili Kauppinen; Mikko I Kettunen; Seppo Yla-Herttuala; David N Finegold; Robert E Ferrell; Kari Alitalo
A model for gene therapy of human hereditary lymphedema.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(22):12677-82.
2001: Mikko O Laukkanen; P Leppanen; Päivi Turunen; Tiina T Tuomisto; Jonne Naarala; Seppo Yla-Herttuala
EC-SOD gene therapy reduces paracetamol-induced liver damage in mice.
The journal of gene medicine 2001;3(4):321-5.
2001: Kalevi Juhani Pulkkanen; Jyrki Parkkinen; J M Laukkanen; Mikko I Kettunen; K Tyynela; Risto A Kauppinen; Martti Ala-Opas; Seppo Yla-Herttuala
HSV-tk gene therapy for human renal cell carcinoma in nude mice.
Cancer gene therapy 2001;8(7):529-36.
2001: Berndt Enholm; Terhi Karpanen; Michael Jeltsch; Hajime Kubo; F Stenback; Remko Prevo; David G Jackson; Seppo Yla-Herttuala; Kari Alitalo
Adenoviral expression of vascular endothelial growth factor-C induces lymphangiogenesis in the skin.
Circulation research 2001;88(6):623-9.
2000: Kalevi Juhani Pulkkanen; Mikko O Laukkanen; Jonne Naarala; Seppo Yla-Herttuala
False-positive apoptosis signal in mouse kidney and liver detected with TUNEL assay.
Apoptosis : an international journal on programmed cell death 2000;5(4):329-33.
2000: Ian Zachary; A Mathur; Seppo Yla-Herttuala; John Martin
Vascular protection: A novel nonangiogenic cardiovascular role for vascular endothelial growth factor.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(6):1512-20.
2000: Kalevi Juhani Pulkkanen; J J Parkkinen; M I Kettunen; Risto A Kauppinen; M Lappalainen; Martti Ala-Opas; Seppo Yla-Herttuala
Characterization of a new animal model for human renal cell carcinoma.
In vivo (Athens, Greece) 2000;14(3):393-400.