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Seppo Ylä-Herttuala

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Krista M Honkonen; Mari Koivisto; Markku T Lähteenvuo; Kari K Alitalo; Paavo J Halonen; Tomi V Tervala; Mikko T Visuri; Seppo Ylä-Herttuala; Anne Saaristo
Lymph node transfer and perinodal lymphatic growth factor treatment for lymphedema.
Haja-Sherief N Musthafa; Lyubomir Petrov; Elias Ylä-Herttuala; Seppo Ylä-Herttuala; Galina Dragneva; Olli H J Gröhn; Tommi Heikura; Line Lottonen; Mari Merentie; Timo Liimatainen
Longitudinal rotating frame relaxation time measurements in infarcted mouse myocardium in vivo.
Renata S M Gomes; Petra Korpisalo; Timmo Liimatainen; Ana Lima; Ricardo Pires das Neves; Mikko Turunen; Seppo Ylä-Herttuala; Carolyn Carr; Rui Carvalho; Kieran Clarke; Lowri Cochlin; Galina Dragneva; Lino Ferreira
Efficient Pro-survival/angiogenic miRNA Delivery by an MRI-Detectable Nanomaterial.

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All Publications

2013: Krista M Honkonen; Mari Koivisto; Markku T Lähteenvuo; Kari K Alitalo; Paavo J Halonen; Tomi V Tervala; Mikko T Visuri; Seppo Ylä-Herttuala; Anne Saaristo
Lymph node transfer and perinodal lymphatic growth factor treatment for lymphedema.
Annals of surgery 2013;257(5):961-7.
2013: Haja-Sherief N Musthafa; Lyubomir Petrov; Elias Ylä-Herttuala; Seppo Ylä-Herttuala; Galina Dragneva; Olli H J Gröhn; Tommi Heikura; Line Lottonen; Mari Merentie; Timo Liimatainen
Longitudinal rotating frame relaxation time measurements in infarcted mouse myocardium in vivo.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2013;69(5):1389-95.
2013: Renata S M Gomes; Petra Korpisalo; Timmo Liimatainen; Ana Lima; Ricardo Pires das Neves; Mikko Turunen; Seppo Ylä-Herttuala; Carolyn Carr; Rui Carvalho; Kieran Clarke; Lowri Cochlin; Galina Dragneva; Lino Ferreira
Efficient Pro-survival/angiogenic miRNA Delivery by an MRI-Detectable Nanomaterial.
ACS nano 2013;7(4):3362-72.
2013: Kari J Airenne; Yu-Chen Hu; Thomas A Kost; Robert M Kotin; Yoshiharu Matsuura; Chikako Ono; Richard H Smith; Shu Wang; Seppo Ylä-Herttuala
Baculovirus: an insect-derived vector for diverse gene transfer applications.
Molecular therapy : the journal of the American Society of Gene Therapy 2013;21(4):739-49.
2013: Anna-Kaisa Ruotsalainen; Tero Vatanen; Masayuki Yamamoto; Seppo Ylä-Herttuala; Petri I Mäkinen; Mervi E Partanen; Janne Heikkilä; Suvi E Heinonen; Sohvi Hörkkö; Matias Inkala; Matti Jauhiainen; Emilia Kansanen; Heidi M Laitinen; Jari P Lappalainen; Anna-Liisa Levonen
The absence of macrophage Nrf2 promotes early atherogenesis.
Cardiovascular research 2013;98(1):107-15.
2013: Petri I Mäkinen; Seppo Ylä-Herttuala
Therapeutic gene targeting approaches for the treatment of dyslipidemias and atherosclerosis.
Current opinion in lipidology 2013;24(2):116-22.
2013: Galina Dragneva; Petra Korpisalo; Seppo Ylä-Herttuala
Promoting blood vessel growth in ischemic diseases: challenges in translating preclinical potential into clinical success.
Disease models & mechanisms 2013;6(2):312-22.
2013: Diana Schenkwein; Oskari Timonen; Vesa Turkki; Mervi K Ahlroth; Kari J Airenne; Seppo Ylä-Herttuala
rDNA-directed integration by an HIV-1 integrase--I-PpoI fusion protein.
Nucleic acids research 2013;41(5):e61.
2013: Andrey Anisimov; Chulhee Choi; Elisabetta Dejana; Emília Ilona Gaál; Eun Chun Han; Tanja Holopainen; Michael Jeltsch; Salla Keskitalo; Gou Young Koh; Young Jun Koh; Petra Korpisalo; Veli-Matti Leppänen; Fabrizio Orsenigo; Pipsa Saharinen; Tuomas Tammela; Denis Tvorogov; Seppo Ylä-Herttuala; Annamari Alitalo; Yuri An; Kari Alitalo
Vascular endothelial growth factor-angiopoietin chimera with improved properties for therapeutic angiogenesis.
Circulation 2013;127(4):424-34.
2013: Taina A Partanen; Anne Pitkäranta; Päivi Salminen; Pia Vuola; Kari Alitalo; Sanna-Kaisa Häkkinen; Krista Honkonen; Suvi Jauhiainen; Jouko Lohi; Seppo Ylä-Herttuala
Neuropilin-2 and vascular endothelial growth factor receptor-3 are up-regulated in human vascular malformations.
Angiogenesis 2013;16(1):137-46.
2012: Suvi K Soininen; Thomas Wirth; Seppo Ylä-Herttuala; David L Selwood; Brigitte Allart; Galina Dragneva; Marjo Jauhiainen; Minna U Kaikkonen; Tanja Karppinen; Pauliina Lehtolainen-Dalkilic; Hanna P Lesch; Ann-Marie Määttä; Jukka Mönkkönen; Tiina Puustinen; Marika Ruponen
Targeted delivery via avidin fusion protein: intracellular fate of biotinylated doxorubicin derivative and cellular uptake kinetics and biodistribution of biotinylated liposomes.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2012;47(5):848-56.
2012: Antti Kivelä; Anna-Liisa Levonen; Marike H Dijkstra; Erika Gurzeler; Suvi E Heinonen; Suvi Jauhiainen; Seppo Ylä-Herttuala
Regulation of endothelial lipase and systemic HDL cholesterol levels by SREBPs and VEGF-A.
Atherosclerosis 2012;225(2):335-40.
2012: Jenni Huusko; Line Lottonen; Mari Merentie; Atsushi Miyanohara; Pasi Tavi; Kari Alitalo; Andrey Anisimov; Erika Gurzeler; Seppo Ylä-Herttuala
AAV9-mediated VEGF-B gene transfer improves systolic function in progressive left ventricular hypertrophy.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(12):2212-21.
2012: A Pacholska; J Pikkarainen; H Samaranayake; T Wirth; F Ahmad; Seppo Ylä-Herttuala
Increased invasion of malignant gliomas after 15-LO-1 and HSV-tk/ganciclovir combination gene therapy.
Cancer gene therapy 2012;19(12):870-4.
2012: Hanna M Leinonen; Hanna P Lesch; Minna U Kaikkonen; Emilia Kansanen; Suvi M Kuosmanen; Heidi M Laitinen; Jari P Lappalainen; Ann-Marie Määttä; Jere T Pikkarainen; Anna-Kaisa Ruotsalainen; Haritha Samaranayake; Seppo Ylä-Herttuala; Anna-Liisa Levonen
Oxidative stress-regulated lentiviral TK/GCV gene therapy for lung cancer treatment.
Cancer research 2012;72(23):6227-35.
2012: Rainer Krebs; Michael Jeltsch; Janne J Jokinen; Antti I Nykänen; Jussi O Ropponen; Jussi M Tikkanen; Seppo Ylä-Herttuala; Karl B Lemström
Critical role of VEGF-C/VEGFR-3 signaling in innate and adaptive immune responses in experimental obliterative bronchiolitis.
The American journal of pathology 2012;181(5):1607-20.
2012: Seppo Ylä-Herttuala
Endgame: glybera finally recommended for approval as the first gene therapy drug in the European union.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(10):1831-2.
2012: Subramanian Murugan; Ulla Saarela; Jingdong Shan; Ilya Skovorodkin; Kari Airenne; Seppo Ylä-Herttuala; Seppo Vainio
Conditional expression of Lodavin, an avidin-tagged LDL receptor, for biotin-mediated applications in vivo.
Genesis (New York, N.Y. : 2000) 2012;50(9):693-9.
2012: Antti Saraste; Axel Walch; Axel W Weber; Eliane Weidl; Hans-Jürgen Wester; Moritz Wildgruber; Seppo Ylä-Herttuala; Irene Esposito; Gabriele Hölzlwimmer; Juhani Knuuti; Iina Laitinen; Pia Leppänen; Irina Lisinen; Peter B Luppa; Stephan Nekolla; Markus Schwaiger
Diet intervention reduces uptake of αvβ3 integrin-targeted PET tracer 18F-galacto-RGD in mouse atherosclerotic plaques.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2012;19(4):775-84.
2012: Johanna Kuusisto; Pertti Jääskeläinen; Vesa Kärjä; Ivana Kholová; Anita Naukkarinen; Keijo Peuhkurinen; Kari Punnonen; Petri Sipola; Seppo Ylä-Herttuala; Markku Laakso
Low-grade inflammation and the phenotypic expression of myocardial fibrosis in hypertrophic cardiomyopathy.
Heart (British Cardiac Society) 2012;98(13):1007-13.
2012: K Muona; M Hedman; K Mäkinen; H Manninen; Seppo Ylä-Herttuala
10-year safety follow-up in patients with local VEGF gene transfer to ischemic lower limb.
Gene therapy 2012;19(4):392-5.
2012: Tanja Holopainen; Gou Young Koh; Anita Lampinen; Ching Ching Leow; Marja Lohela; Pipsa Saharinen; Raija Sormunen; Tuomas Tammela; Seppo Ylä-Herttuala; Georgia Zarkada; Andrey Anisimov; Laura E Benjamin; Gabriela D'Amico; Lauri Eklund; Hanna Heloterä; Kari Alitalo
Effects of angiopoietin-2-blocking antibody on endothelial cell-cell junctions and lung metastasis.
Journal of the National Cancer Institute 2012;104(6):461-75.
2012: Thomas Maldiney; Daniel Scherman; Johanne Seguin; Seppo Ylä-Herttuala; Kari J Airenne; Michel Bessodes; Minna U Kaikkonen; Quentin le Masne de Chermont; Cyrille Richard
In vitro targeting of avidin-expressing glioma cells with biotinylated persistent luminescence nanoparticles.
Bioconjugate chemistry 2012;23(3):472-8.
2012: Seppo Ylä-Herttuala
The need for increased clarity and transparency in the regulatory pathway for gene medicines in the European Union.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(3):471-2.
2012: Antti Kotimaa; Hanna P Lesch; Eveliina Pulkkinen; Hanna Stedt; Suvi E Heinonen; Jenni Huusko; Ivana Kholová; Anna-Mari Zainana; Seppo Ylä-Herttuala
Endothelium-specific overexpression of human vascular endothelial growth factor-D in mice leads to increased tumor frequency and a reduced lifespan.
The journal of gene medicine 2012;14(3):182-90.
2012: Kati Kinnunen; Seppo Ylä-Herttuala
Vascular endothelial growth factors in retinal and choroidal neovascular diseases.
Annals of medicine 2012;44(1):1-17.
2012: Hanna Stedt; Laura Alasaarela; Ivana Kholová; Ann-Marie Määttä; Aaron S Parker; Jere Pikkarainen; Haritha Samaranayake; Seppo Ylä-Herttuala
Specific inhibition of SRC kinase impairs malignant glioma growth in vitro and in vivo.
Molecular therapy. Nucleic acids 2012;1():e19.
2012: Raine Toivonen; Seppo Ylä-Herttuala; Juha Koskenvuo; Mari Merentie; Mirva Söderström; Mikko Savontaus
Intracardiac injection of a capsid-modified Ad5/35 results in decreased heart toxicity when compared to standard Ad5.
Virology journal 2012;9():296.
2012: Antti Kivelä; Juha Hartikainen; Seppo Ylä-Herttuala
Dotted collar placed around carotid artery induces asymmetric neointimal lesion formation in rabbits without intravascular manipulations.
BMC cardiovascular disorders 2012;12():91.
2012: Tommi Heikura; Minna U Kaikkonen; Henna Karvinen; Olli H Laitinen; Hanna P Lesch; Anssi J Mähönen; Tiina Nieminen; Tuomas T Rissanen; Miia M Roschier; Kari J Airenne; Seppo Ylä-Herttuala
Baculovirus-mediated vascular endothelial growth factor-D(ΔNΔC) gene transfer induces angiogenesis in rabbit skeletal muscle.
The journal of gene medicine 2012;14(1):35-43.
2011: Kati H Pulkkinen; Seppo Ylä-Herttuala; Anna-Liisa Levonen
Heme oxygenase 1 is induced by miR-155 via reduced BACH1 translation in endothelial cells.
Free radical biology & medicine 2011;51(11):2124-31.
2011: Henna-Kaisa Jyrkkänen; Emilia Kansanen; Suvi Kuosmanen; Heidi Laitinen; Hanna Leinonen; Eero Mella-Aho; Seppo Ylä-Herttuala; Merja Heinäniemi; Anna-Liisa Levonen
Novel insights into the regulation of antioxidant-response-element-mediated gene expression by electrophiles: induction of the transcriptional repressor BACH1 by Nrf2.
The Biochemical journal 2011;440(2):167-74.
2011: Tuomas Tammela; Denis Tvorogov; Seppo Ylä-Herttuala; Georgia Zarkada; Wei Zheng; Evelyn Aranda; Anne Eichmann; Claudio A Franco; Marcus Fruttiger; Holger Gerhardt; Krista Heinolainen; Lars Jakobsson; Taija Mäkinen; Naoyuki Miura; Aino Murtomäki; Harri Nurmi; Jeffrey W Pollard; Kari Alitalo
VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling.
Nature cell biology 2011;13(10):1202-13.
2011: Farizan Ahmad; Agnieszka Pacholska; Venla Tuppurainen; Seppo Ylä-Herttuala; Anna Hyvärinen
Resectable VX-2 rabbit brain tumor model for development of intraoperative local administration of drugs.
Acta neurochirurgica 2011;153(10):1979-81.
2011: Wei Zheng; Andrey Anisimov; Tanja Holopainen; S Kaijalainen; Terhi Karpanen; Kaisa Lehti; Tuomas Tammela; Masahiro Yamamoto; Seppo Ylä-Herttuala; Kari Alitalo
Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor.
Blood 2011;118(4):1154-62.
2011: Suvi Jauhiainen; Henna-Kaisa Jyrkkänen; Emilia Kansanen; Hanna Leinonen; Anna-Liisa Levonen; Pyry I Toivanen; Sanna-Kaisa Häkkinen; Suvi E Heinonen; Seppo Ylä-Herttuala
Vascular endothelial growth factor (VEGF)-D stimulates VEGF-A, stanniocalcin-1, and neuropilin-2 and has potent angiogenic effects.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(7):1617-24.
2011: Petra Korpisalo; Svetlana Laidinen; Johannes T T Laitinen; Varpu Marjomäki; Henna Parviainen; Tuomas T Rissanen; Jaana Siponen; Ismo Vajanto; Jarkko P Hytönen; Henna Karvinen; Seppo Ylä-Herttuala
Capillary enlargement, not sprouting angiogenesis, determines beneficial therapeutic effects and side effects of angiogenic gene therapy.
European heart journal 2011;32(13):1664-72.
2011: Seppo Ylä-Herttuala; Christopher K Glass
Review focus on epigenetics and the histone code in vascular biology.
Cardiovascular research 2011;90(3):402-3.
2011: Mikko P Turunen; Seppo Ylä-Herttuala
Epigenetic regulation of key vascular genes and growth factors.
Cardiovascular research 2011;90(3):441-6.
2011: Mitja I Kurki; Mika Niemelä; Gerard Tromp; Riikka Tulamo; Mikael von und zu Fraunberg; Garry Wong; Juhana Frösen; Sanna-Kaisa Häkkinen; Juha Hernesniemi; Juha E Jääskeläinen; Seppo Ylä-Herttuala
Upregulated signaling pathways in ruptured human saccular intracranial aneurysm wall: an emerging regulative role of Toll-like receptor signaling and nuclear factor-κB, hypoxia-inducible factor-1A, and ETS transcription factors.
Neurosurgery 2011;68(6):1667-75; discussion 1675-6.
2011: Johanna M U Silvola; Antti Saraste; Sarita Forsback; V Jukka O Laine; Pekka Saukko; Suvi E Heinonen; Seppo Ylä-Herttuala; Anne Roivainen; Juhani Knuuti
Detection of hypoxia by [18F]EF5 in atherosclerotic plaques in mice.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(5):1011-5.
2011: Ivana Kholová; Galina Dragneva; Petra Cermáková; Svetlana Laidinen; Nina Kaskenpää; Thierry Hazes; Eva Cermáková; Ivo Steiner; Seppo Ylä-Herttuala
Lymphatic vasculature is increased in heart valves, ischaemic and inflamed hearts and in cholesterol-rich and calcified atherosclerotic lesions.
European journal of clinical investigation 2011;41(5):487-97.
2011: Emilia Kansanen; Gustavo Bonacci; Francisco J Schopfer; Suvi M Kuosmanen; Kit I Tong; Hanna Leinonen; Steven R Woodcock; Masayuki Yamamoto; Carsten Carlberg; Seppo Ylä-Herttuala; Bruce A Freeman; Anna-Liisa Levonen
Electrophilic nitro-fatty acids activate NRF2 by a KEAP1 cysteine 151-independent mechanism.
The Journal of biological chemistry 2011;286(16):14019-27.
2011: Seppo Ylä-Herttuala; Thomas Wirth
Therapeutic delivery using gene-delivery methods.
Therapeutic delivery 2011;2(4):423-6.
2011: Markku Lähteenvuo; Krista Honkonen; Tomi Tervala; Tuomas Tammela; Erkki Suominen; Johanna Lähteenvuo; Ivana Kholová; Kari Alitalo; Seppo Ylä-Herttuala; Anne Saaristo
Growth factor therapy and autologous lymph node transfer in lymphedema.
Circulation 2011;123(6):613-20.
2011: Tuomas Tammela; Anne Saaristo; Tanja Holopainen; Seppo Ylä-Herttuala; Leif C Andersson; Susanna Virolainen; Ilkka Immonen; Kari Alitalo
Photodynamic ablation of lymphatic vessels and intralymphatic cancer cells prevents metastasis.
Science translational medicine 2011;3(69):69ra11.
2011: Veli-Matti Leppänen; Michael Jeltsch; Andrey Anisimov; Denis Tvorogov; Kukka Aho; Nisse Kalkkinen; Pyry Toivanen; Seppo Ylä-Herttuala; Kurt Ballmer-Hofer; Kari Alitalo
Structural determinants of vascular endothelial growth factor-D receptor binding and specificity.
Blood 2011;117(5):1507-15.
2011: Seppo Ylä-Herttuala
Gene therapy moves forward in 2010.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(2):219-20.
2011: H Sallinen; M Anttila; O Gröhn; J Koponen; K Hämäläinen; I Kholova; V-M Kosma; S Heinonen; Kari Alitalo; Seppo Ylä-Herttuala
Cotargeting of VEGFR-1 and -3 and angiopoietin receptor Tie2 reduces the growth of solid human ovarian cancer in mice.
Cancer gene therapy 2011;18(2):100-9.
2011: Suvi E Heinonen; Ivana Kholová; Markku Laakso; Elina Loponen; Petri I Mäkinen; Mari Merentie; Fatima Bosch; Marja Hedman; Seppo Ylä-Herttuala
Left ventricular dysfunction with reduced functional cardiac reserve in diabetic and non-diabetic LDL-receptor deficient apolipoprotein B100-only mice.
Cardiovascular diabetology 2011;10():59.
2011: Mitja I Kurki; Jussi Paananen; Juha E Jääskeläinen; Markus Storvik; Mikael von und zu Fraunberg; Garry Wong; Seppo Ylä-Herttuala; Petri Pehkonen
TAFFEL: Independent Enrichment Analysis of gene sets.
BMC bioinformatics 2011;12():171.
2011: Kari J Airenne; Kaisa-Emilia Makkonen; Anssi J Mähönen; Seppo Ylä-Herttuala
Baculoviruses mediate efficient gene expression in a wide range of vertebrate cells.
Methods in molecular biology (Clifton, N.J.) 2011;737():279-301.
2011: Mattias Kalén; Tommi Heikura; Henna Karvinen; Anja Nitzsche; Holger Weber; Norbert Esser; Seppo Ylä-Herttuala; Mats Hellström
Gamma-secretase inhibitor treatment promotes VEGF-A-driven blood vessel growth and vascular leakage but disrupts neovascular perfusion.
PloS one 2011;6(4):e18709.
2011: Raisa Serpi; Anna-Maria Tolonen; Jenni Huusko; Jaana Rysä; Olli Tenhunen; Seppo Ylä-Herttuala; Heikki Ruskoaho
Vascular endothelial growth factor-B gene transfer prevents angiotensin II-induced diastolic dysfunction via proliferation and capillary dilatation in rats.
Cardiovascular research 2011;89(1):204-13.
2010: Hanna Sallinen; Tommi Heikura; Svetlana Laidinen; Veli-Matti Kosma; Seppo Heinonen; Seppo Ylä-Herttuala; Maarit Anttila
Preoperative angiopoietin-2 serum levels: a marker of malignant potential in ovarian neoplasms and poor prognosis in epithelial ovarian cancer.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2010;20(9):1498-505.
2010: Petri I Mäkinen; Jari P Lappalainen; Suvi E Heinonen; Pia Leppänen; Markku T Lähteenvuo; Jussi V Aarnio; Janne Heikkilä; Mikko Turunen; Seppo Ylä-Herttuala
Silencing of either SR-A or CD36 reduces atherosclerosis in hyperlipidaemic mice and reveals reciprocal upregulation of these receptors.
Cardiovascular research 2010;88(3):530-8.
2010: Tuulia Huhtala; Pirjo Laakkonen; Hanna Sallinen; Seppo Ylä-Herttuala; Ale Närvänen
In vivo SPECT/CT imaging of human orthotopic ovarian carcinoma xenografts with 111In-labeled monoclonal antibodies.
Nuclear medicine and biology 2010;37(8):957-64.
2010: Juha M Matilainen; Tiia Husso; Sari Toropainen; Sabine Seuter; Mikko P Turunen; Petra Gynther; Seppo Ylä-Herttuala; Carsten Carlberg; Sami Väisänen
Primary effect of 1α,25(OH)₂D₃ on IL-10 expression in monocytes is short-term down-regulation.
Biochimica et biophysica acta 2010;1803(11):1276-86.
2010: Annukka M Kivelä; Petri I Mäkinen; Henna-Kaisa Jyrkkänen; Eero Mella-Aho; Yifeng Xia; Emilia Kansanen; Hanna Leinonen; Inder M Verma; Seppo Ylä-Herttuala; Anna-Liisa Levonen
Sulforaphane inhibits endothelial lipase expression through NF-κB in endothelial cells.
Atherosclerosis 2010;213(1):122-8.
2010: Maija Bry; Riikka Kivelä; Tanja Holopainen; Andrey Anisimov; Tuomas Tammela; Jarkko Soronen; Johanna Silvola; Antti Saraste; Michael Jeltsch; Petra Korpisalo; Peter Carmeliet; Karl B Lemström; Masabumi Shibuya; Seppo Ylä-Herttuala; Leena Alhonen; Eero Mervaala; Leif C Andersson; Juhani Knuuti; Kari Alitalo
Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation.
Circulation 2010;122(17):1725-33.
2010: Kari J Airenne; Kaisa-Emilia Makkonen; Anssi J Mähönen; Seppo Ylä-Herttuala
In vivo application and tracking of baculovirus.
Current gene therapy 2010;10(3):187-94.
2010: Virpi Lämsä; Anna-Liisa Levonen; Hanna Leinonen; Seppo Ylä-Herttuala; Masayuki Yamamoto; Jukka Hakkola
Cytochrome P450 2A5 constitutive expression and induction by heavy metals is dependent on redox-sensitive transcription factor Nrf2 in liver.
Chemical research in toxicology 2010;23(5):977-85.
2010: Himadri Roy; Shalini Bhardwaj; Mohan Babu; Johanna E Lähteenvuo; Seppo Ylä-Herttuala
VEGF-DdeltaNdeltaC mediated angiogenesis in skeletal muscles of diabetic WHHL rabbits.
European journal of clinical investigation 2010;40(5):422-32.
2010: Iina E K Laitinen; Pauliina Luoto; Kjell Någren; Päivi M Marjamäki; Johanna M U Silvola; Sanna Hellberg; V Jukka O Laine; Seppo Ylä-Herttuala; Juhani Knuuti; Anne Roivainen
Uptake of 11C-choline in mouse atherosclerotic plaques.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2010;51(5):798-802.
2010: Minna U Kaikkonen; Antti I Maatta; Seppo Ylä-Herttuala; Kari J Airenne
Screening of complement inhibitors: shielded baculoviruses increase the safety and efficacy of gene delivery.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(5):987-92.
2010: Diana Schenkwein; Vesa Turkki; Hanna-Riikka Kärkkäinen; Kari J Airenne; Seppo Ylä-Herttuala
Production of HIV-1 integrase fusion protein-carrying lentiviral vectors for gene therapy and protein transduction.
Human gene therapy 2010;21(5):589-602.
2010: Carolina E Hagberg; Annelie Falkevall; Xun Wang; Erik Larsson; Jenni Huusko; Ingrid Nilsson; Laurens van Meeteren; Erik Samen; Li Lu; Maarten Vanwildemeersch; Joakim Klar; Guillem Genove; Kristian Pietras; Sharon Stone-Elander; Lena Claesson-Welsh; Seppo Ylä-Herttuala; Per Lindahl; Ulf Eriksson
Vascular endothelial growth factor B controls endothelial fatty acid uptake.
Nature 2010;464(7290):917-21.
2010: Henna Karvinen; Seppo Ylä-Herttuala
New aspects in vascular gene therapy.
Current opinion in pharmacology 2010;10(2):208-11.
2010: Haritha Samaranayake; Ann-Marie Määttä; Jere Pikkarainen; Seppo Ylä-Herttuala
Future prospects and challenges of antiangiogenic cancer gene therapy.
Human gene therapy 2010;21(4):381-96.
2010: Jenni Huusko; Mari Merentie; Marike H Dijkstra; Minttu-Maria Ryhänen; Henna Karvinen; Tuomas T Rissanen; Maarten Vanwildemeersch; Marja Hedman; Jukka Lipponen; Suvi E Heinonen; Ulf Eriksson; Masabumi Shibuya; Seppo Ylä-Herttuala
The effects of VEGF-R1 and VEGF-R2 ligands on angiogenic responses and left ventricular function in mice.
Cardiovascular research 2010;86(1):122-30.
2010: Antti I Nykänen; Henrik Sandelin; Rainer Krebs; Mikko A I Keränen; Raimo Tuuminen; Terhi Kärpänen; Yan Wu; Bronislaw Pytowski; Petri K Koskinen; Seppo Ylä-Herttuala; Kari Alitalo; Karl B Lemström
Targeting lymphatic vessel activation and CCL21 production by vascular endothelial growth factor receptor-3 inhibition has novel immunomodulatory and antiarteriosclerotic effects in cardiac allografts.
Circulation 2010;121(12):1413-22.
2010: Petra Korpisalo; Seppo Ylä-Herttuala
Stimulation of functional vessel growth by gene therapy.
Integrative biology : quantitative biosciences from nano to macro 2010;2(2-3):102-12.
2010: Teemu Olavi Ihalainen; Johanna P Laakkonen; Outi Paloheimo; Seppo Ylä-Herttuala; Kari J Airenne; Maija Vihinen-Ranta
Morphological characterization of baculovirus Autographa californica multiple nucleopolyhedrovirus.
Virus research 2010;148(1-2):71-4.
2010: Anssi J Mähönen; Kaisa-Emilia Makkonen; Johanna P Laakkonen; Teemu Olavi Ihalainen; Sari P Kukkonen; Minna U Kaikkonen; Maija Vihinen-Ranta; Seppo Ylä-Herttuala; Kari J Airenne
Culture medium induced vimentin reorganization associates with enhanced baculovirus-mediated gene delivery.
Journal of biotechnology 2010;145(2):111-9.
2009: Seppo Ylä-Herttuala
Gene therapy with vascular endothelial growth factors.
Biochemical Society transactions 2009;37(Pt 6):1198-200.
2009: Helena Viita; Kati Kinnunen; Emmi Eriksson; Johanna Lähteenvuo; Mohan Babu; Giedrius Kalesnykas; Tommi Heikura; Svetlana Laidinen; Teemu Takalo; Seppo Ylä-Herttuala
Intravitreal adenoviral 15-lipoxygenase-1 gene transfer prevents vascular endothelial growth factor A-induced neovascularization in rabbit eyes.
Human gene therapy 2009;20(12):1679-86.
2009: Emilia Kansanen; Henna-Kaisa Jyrkkänen; Oscar L Volger; Hanna Leinonen; Antti Kivelä; Sanna-Kaisa Häkkinen; Steven R Woodcock; Francisco J Schopfer; Anton J Horrevoets; Seppo Ylä-Herttuala; Bruce Freeman; Anna-Liisa Levonen
Nrf2-dependent and -independent responses to nitro-fatty acids in human endothelial cells: identification of heat shock response as the major pathway activated by nitro-oleic acid.
The Journal of biological chemistry 2009;284(48):33233-41.
2009: Ann-Marie Määttä; Haritha Samaranayake; Jere Pikkarainen; Thomas Wirth; Seppo Ylä-Herttuala
Adenovirus mediated herpes simplex virus-thymidine kinase/ganciclovir gene therapy for resectable malignant glioma.
Current gene therapy 2009;9(5):356-67.
2009: Thomas Wirth; Haritha Samaranayake; Jere Pikkarainen; Ann-Marie Määttä; Seppo Ylä-Herttuala
Clinical trials for glioblastoma multiforme using adenoviral vectors.
Current opinion in molecular therapeutics 2009;11(5):485-92.
2009: Laura Lahtinen; N Huusko; H Myöhänen; A-K Lehtivarjo; Riikka Pellinen; Mikko Turunen; Seppo Ylä-Herttuala; Eija Pirinen; Asla Pitkänen
Expression of urokinase-type plasminogen activator receptor is increased during epileptogenesis in the rat hippocampus.
Neuroscience 2009;163(1):316-28.
2009: Katja Kanninen; Riikka Heikkinen; Tarja M Malm; Taisia Rolova; Susanna Kuhmonen; Hanna Leinonen; Seppo Ylä-Herttuala; Heikki Tanila; Anna-Liisa Levonen; Milla Koistinaho; Jari Koistinaho
Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(38):16505-10.
2009: Mikko P Turunen; Tiia Lehtola; Suvi E Heinonen; Genet S Assefa; Petra Korpisalo; Roseanne Girnary; Christopher K Glass; Sami Väisänen; Seppo Ylä-Herttuala
Efficient regulation of VEGF expression by promoter-targeted lentiviral shRNAs based on epigenetic mechanism: a novel example of epigenetherapy.
Circulation research 2009;105(6):604-9.
2009: Mikko P Turunen; Einari Aavik; Seppo Ylä-Herttuala
Epigenetics and atherosclerosis.
Biochimica et biophysica acta 2009;1790(9):886-91.
2009: Hanna P Lesch; Jere T Pikkarainen; Minna U Kaikkonen; Miia Taavitsainen; Haritha Samaranayake; Pauliina Lehtolainen-Dalkilic; Taina Vuorio; Ann-Marie Määttä; Thomas Wirth; Kari J Airenne; Seppo Ylä-Herttuala
Avidin fusion protein-expressing lentiviral vector for targeted drug delivery.
Human gene therapy 2009;20(8):871-82.
2009: Kati Kinnunen; Tuomo Puustjärvi; Markku Teräsvirta; P Nurmenniemi; Tommi Heikura; S Laidinen; T Paavonen; Hannu Uusitalo; Seppo Ylä-Herttuala
Differences in retinal neovascular tissue and vitreous humour in patients with type 1 and type 2 diabetes.
The British journal of ophthalmology 2009;93(8):1109-15.
2009: Iina Laitinen; Antti Saraste; Eliane Weidl; Thorsten Poethko; Axel W Weber; Stephan Nekolla; Pia Leppänen; Seppo Ylä-Herttuala; Gabriele Hölzlwimmer; Axel Walch; Irene Esposito; Hans-Jürgen Wester; Juhani Knuuti; Markus Schwaiger
Evaluation of alphavbeta3 integrin-targeted positron emission tomography tracer 18F-galacto-RGD for imaging of vascular inflammation in atherosclerotic mice.
Circulation. Cardiovascular imaging 2009;2(4):331-8.
2009: Minna U Kaikkonen; H P Lesch; J Pikkarainen; Jani Räty; T Vuorio; Tuulia Huhtala; M Taavitsainen; T Laitinen; P Tuunanen; O Gröhn; Ale Närvänen; Kari J Airenne; Seppo Ylä-Herttuala
(Strept)avidin-displaying lentiviruses as versatile tools for targeting and dual imaging of gene delivery.
Gene therapy 2009;16(7):894-904.
2009: Andrey Anisimov; Annamari Alitalo; Petra Korpisalo; Jarkko Soronen; S Kaijalainen; Veli-Matti Leppänen; Michael Jeltsch; Seppo Ylä-Herttuala; Kari Alitalo
Activated forms of VEGF-C and VEGF-D provide improved vascular function in skeletal muscle.
Circulation research 2009;104(11):1302-12.
2009: Pyry I Toivanen; Tiina Nieminen; Lenita Viitanen; Annamari Alitalo; Miia Roschier; Suvi Jauhiainen; Johanna E Markkanen; Olli H Laitinen; Tomi T Airenne; Tiina A Salminen; Mark S Johnson; Kari J Airenne; Seppo Ylä-Herttuala
Novel vascular endothelial growth factor D variants with increased biological activity.
The Journal of biological chemistry 2009;284(23):16037-48.
2009: Camilla Norrmén; Konstantin I Ivanov; Jianpin Cheng; Nadine Zangger; Mauro Delorenzi; Muriel Jaquet; Naoyuki Miura; Pauli Puolakkainen; Valerie Horsley; Junhao Hu; Hellmut G Augustin; Seppo Ylä-Herttuala; Kari Alitalo; Tatiana V Petrova
FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1.
The Journal of cell biology 2009;185(3):439-57.
2009: Kati Kinnunen; Giedrius Kalesnykas; Anssi J Mähönen; Svetlana Laidinen; Liisa Holma; Tommi Heikura; Kari Airenne; Hannu Uusitalo; Seppo Ylä-Herttuala
Baculovirus is an efficient vector for the transduction of the eye: comparison of baculovirus- and adenovirus-mediated intravitreal vascular endothelial growth factor D gene transfer in the rabbit eye.
The journal of gene medicine 2009;11(5):382-9.
2009: M Hedman; K Muona; Antti Hedman; Antti Kivelä; Mikko Syvänne; J Eränen; Arto Rantala; J Stjernvall; Markku S Nieminen; Juha Hartikainen; Seppo Ylä-Herttuala
Eight-year safety follow-up of coronary artery disease patients after local intracoronary VEGF gene transfer.
Gene therapy 2009;16(5):629-34.
2009: Anna-Mari Kärkkäinen; Antti Kotimaa; Jenni Huusko; Ivana Kholova; Suvi Elina Heinonen; Anna Stefanska; Marike Hinke Dijkstra; Hanna Purhonen; Eveliina Hämäläinen; Petri Ilmari Mäkinen; Mikko Petri Turunen; Seppo Ylä-Herttuala
Vascular endothelial growth factor-D transgenic mice show enhanced blood capillary density, improved postischemic muscle regeneration, and increased susceptibility to tumor formation.
Blood 2009;113(18):4468-75.
2009: H Karvinen; Juha Rutanen; Olli Leppänen; R Lach; Anna-Liisa Levonen; Ulf Eriksson; Seppo Ylä-Herttuala
PDGF-C and -D and their receptors PDGFR-alpha and PDGFR-beta in atherosclerotic human arteries.
European journal of clinical investigation 2009;39(4):320-7.
2009: Kari J Airenne; Olli H Laitinen; Anssi J Mähönen; Seppo Ylä-Herttuala
Transduction of vertebrate cells with recombinant baculovirus.
Cold Spring Harbor protocols 2009;2009(3):pdb.prot5182.
2009: Kari J Airenne; Olli H Laitinen; Anssi J Mähönen; Seppo Ylä-Herttuala
Preparation of recombinant baculoviruses with the BVboost system.
Cold Spring Harbor protocols 2009;2009(3):pdb.prot5181.
2009: Johanna E Lähteenvuo; Markku T Lähteenvuo; Antti Kivelä; Carolina Rosenlew; Annelie Falkevall; Joakim Klar; Tommi Heikura; Tuomas T Rissanen; Elisa Vähäkangas; Petra Korpisalo; Berndt Enholm; Peter Carmeliet; Kari Alitalo; Ulf Eriksson; Seppo Ylä-Herttuala
Vascular endothelial growth factor-B induces myocardium-specific angiogenesis and arteriogenesis via vascular endothelial growth factor receptor-1- and neuropilin receptor-1-dependent mechanisms.
Circulation 2009;119(6):845-56.
2009: Hanna-Riikka Kärkkäinen; Hanna P Lesch; Antti I Määttä; Pyry I Toivanen; Anssi J Mähönen; Miia M Roschier; Kari J Airenne; Olli H Laitinen; Seppo Ylä-Herttuala
A 96-well format for a high-throughput baculovirus generation, fast titering and recombinant protein production in insect and mammalian cells.
BMC research notes 2009;2():63.
2009: Johanna P Laakkonen; Anna R Mäkelä; Elina Kakkonen; Paula Turkki; Sari Kukkonen; Johan Peränen; Seppo Ylä-Herttuala; Kari J Airenne; Christian Oker-Blom; Maija Vihinen-Ranta; Varpu Marjomäki
Clathrin-independent entry of baculovirus triggers uptake of E. coli in non-phagocytic human cells.
PloS one 2009;4(4):e5093.
2009: Lotta Kangasniemi; M Koskinen; M Jokinen; M Toriseva; R Ala-Aho; Veli-Matti Kähäri; H Jalonen; Seppo Ylä-Herttuala; H Moilanen; Ulf-Hakan Stenman; I Diaconu; Anna Kanerva; S Pesonen; Tanja Hakkarainen; Akseli Hemminki
Extended release of adenovirus from silica implants in vitro and in vivo.
Gene therapy 2009;16(1):103-10.
2009: Iina Laitinen; Päivi Marjamäki; Kjell Någren; Jukka Laine; Ian Wilson; Pia Leppänen; Seppo Ylä-Herttuala; Anne Roivainen; Juhani Knuuti
Uptake of inflammatory cell marker [11C]PK11195 into mouse atherosclerotic plaques.
European journal of nuclear medicine and molecular imaging 2009;36(1):73-80.
2008: Ileana Ruxandra Botusan; Vivekananda Gupta Sunkari; Octavian Savu; Anca Irinel Catrina; Jacob Grünler; Stina Lindberg; Teresa Pereira; Seppo Ylä-Herttuala; Lorenz Poellinger; Kerstin Brismar; Sergiu-Bogdan Catrina
Stabilization of HIF-1alpha is critical to improve wound healing in diabetic mice.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(49):19426-31.
2008: Petra Korpisalo; Henna Karvinen; Tuomas T Rissanen; Johanna Kilpijoki; Varpu Marjomäki; Peter Baluk; Donald M McDonald; Yihai Cao; Ulf Eriksson; Kari Alitalo; Seppo Ylä-Herttuala
Vascular endothelial growth factor-A and platelet-derived growth factor-B combination gene therapy prolongs angiogenic effects via recruitment of interstitial mononuclear cells and paracrine effects rather than improved pericyte coverage of angiogenic vessels.
Circulation research 2008;103(10):1092-9.
2008: Katja Kanninen; Tarja M Malm; Henna-Kaisa Jyrkkänen; Gundars Goldsteins; Velta Keksa-Goldsteine; Heikki Tanila; Masayuki Yamamoto; Seppo Ylä-Herttuala; Anna-Liisa Levonen; Jari Koistinaho
Nuclear factor erythroid 2-related factor 2 protects against beta amyloid.
Molecular and cellular neurosciences 2008;39(3):302-13.
2008: Petra Korpisalo; Tuomas T Rissanen; Timo Bengtsson; Timo Liimatainen; Svetlana Laidinen; Henna Karvinen; Johanna E Markkanen; Olli H Gröhn; Seppo Ylä-Herttuala
Therapeutic angiogenesis with placental growth factor improves exercise tolerance of ischaemic rabbit hindlimbs.
Cardiovascular research 2008;80(2):263-70.
2008: Terhi Karpanen; Maija Bry; Hanna M Ollila; Tuulikki Seppänen-Laakso; Erkki Liimatta; Hanna Leskinen; Riikka Kivelä; Teemu Helkamaa; Mari Merentie; Michael Jeltsch; Kristian J Paavonen; Leif C Andersson; Eero Mervaala; Ilmo E Hassinen; Seppo Ylä-Herttuala; Matej Oresic; Kari Alitalo
Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy.
Circulation research 2008;103(9):1018-26.
2008: Anna Kirjavainen; Marilin Sulg; Florian Heyd; Kari Alitalo; Seppo Ylä-Herttuala; Tarik Möröy; Tatiana V Petrova; Ulla Pirvola
Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia.
Developmental biology 2008;322(1):33-45.
2008: Anniina Laurema; Mervi Riekkinen; Tommi Heikura; Elisa Vähäkangas; Hannu Manninen; Seppo Heinonen; Seppo Ylä-Herttuala
The administration of an adenoviral thymidine kinase suicide gene to the uterine artery of rabbits does not affect fertility: a safety study of pregnant and nonpregnant rabbits and their offspring.
The journal of gene medicine 2008;10(9):1005-11.
2008: H P Lesch; S Turpeinen; Einari Niskanen; Anssi J Mähönen; Kari J Airenne; Seppo Ylä-Herttuala
Generation of lentivirus vectors using recombinant baculoviruses.
Gene therapy 2008;15(18):1280-6.
2008: H Hurttila; Jonna K Koponen; E Kansanen; H-K Jyrkkänen; Antti Kivelä; R Kylätie; Seppo Ylä-Herttuala; Anna-Liisa Levonen
Oxidative stress-inducible lentiviral vectors for gene therapy.
Gene therapy 2008;15(18):1271-9.
2008: Antti Saraste; Ville Kytö; Iina Laitinen; Markku Saraste; Pia Leppänen; Seppo Ylä-Herttuala; Pekka Saukko; Jaakko Hartiala; Juhani Knuuti
Severe coronary artery stenoses and reduced coronary flow velocity reserve in atherosclerotic mouse model: Doppler echocardiography validation study.
Atherosclerosis 2008;200(1):89-94.
2008: Tuomas Tammela; Georgia Zarkada; Elisabet Wallgard; Aino Murtomäki; Steven Suchting; Maria Wirzenius; Marika Waltari; Mats Hellström; Tibor Schomber; Reetta Peltonen; Catarina Freitas; António Duarte; Helena Isoniemi; Pirjo Laakkonen; Gerhard Christofori; Seppo Ylä-Herttuala; Masabumi Shibuya; Bronislaw Pytowski; Anne Eichmann; Christer Betsholtz; Kari Alitalo
Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation.
Nature 2008;454(7204):656-60.
2008: Kati Pulkkinen; Tarja Malm; Mikko Turunen; Jari Koistinaho; Seppo Ylä-Herttuala
Hypoxia induces microRNA miR-210 in vitro and in vivo ephrin-A3 and neuronal pentraxin 1 are potentially regulated by miR-210.
FEBS letters 2008;582(16):2397-401.
2008: Henna-Kaisa Jyrkkänen; Emilia Kansanen; Matias Inkala; Annukka M Kivelä; Hanna Hurttila; Suvi E Heinonen; Gundars Goldsteins; Suvi Jauhiainen; Satu Tiainen; Harri Makkonen; Olga Oskolkova; Taras Afonyushkin; Jari Koistinaho; Masayuki Yamamoto; Valery N Bochkov; Seppo Ylä-Herttuala; Anna-Liisa Levonen
Nrf2 regulates antioxidant gene expression evoked by oxidized phospholipids in endothelial cells and murine arteries in vivo.
Circulation research 2008;103(1):e1-9.
2008: Annukka M Kivelä; Emilia Kansanen; Henna-Kaisa Jyrkkänen; Tarja Nurmi; Seppo Ylä-Herttuala; Anna-Liisa Levonen
Enterolactone induces heme oxygenase-1 expression through nuclear factor-E2-related factor 2 activation in endothelial cells.
The Journal of nutrition 2008;138(7):1263-8.
2008: Joost O Fledderus; Reinier A Boon; Oscar L Volger; Hanna Hurttila; Seppo Ylä-Herttuala; Hans Pannekoek; Anna-Liisa Levonen; Anton J G Horrevoets
KLF2 primes the antioxidant transcription factor Nrf2 for activation in endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(7):1339-46.
2008: Caroline A Heckman; Tanja Holopainen; Maria Wirzenius; Salla Keskitalo; Michael Jeltsch; Seppo Ylä-Herttuala; Stephen R Wedge; Juliane M Jürgensmeier; Kari Alitalo
The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis.
Cancer research 2008;68(12):4754-62.
2008: Shalini Bhardwaj; Himadri Roy; Seppo Ylä-Herttuala
Gene therapy to prevent occlusion of venous bypass grafts.
Expert review of cardiovascular therapy 2008;6(5):641-52.
2008: A Sierra; S Michaeli; Juha-Pekka Niskanen; Piia Valonen; Heidi I Gröhn; Seppo Ylä-Herttuala; Michael Garwood; Olli H J Gröhn
Water spin dynamics during apoptotic cell death in glioma gene therapy probed by T1rho and T2rho.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2008;59(6):1311-9.
2008: Timo J Liimatainen; Arja T Erkkilä; Piia Valonen; Helvi Vidgren; Merja Lakso; Garry Wong; Olli H J Gröhn; Seppo Ylä-Herttuala; Juhana M Hakumäki
1H MR spectroscopic imaging of phospholipase-mediated membrane lipid release in apoptotic rat glioma in vivo.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2008;59(6):1232-8.
2008: Minna U Kaikkonen; Jenni I Viholainen; Ale Närvänen; Seppo Ylä-Herttuala; Kari J Airenne
Targeting and purification of metabolically biotinylated baculovirus.
Human gene therapy 2008;19(6):589-600.
2008: M Odermarsky; S Andersson; Erkki Pesonen; Sture Sjöblad; Seppo Ylä-Herttuala; Petru Liuba
Respiratory infection recurrence and passive smoking in early atherosclerosis in children and adolescents with type 1 diabetes.
European journal of clinical investigation 2008;38(6):381-8.
2008: Susanna Lauttia (neé Purhonen); Jarmo Palm; Derrick Rossi; Nina Kaskenpää; Iiro Rajantie; Seppo Ylä-Herttuala; Kari Alitalo; Irving L Weissman; Petri Salven
Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(18):6620-5.
2008: Anna-Liisa Levonen; Elisa Vähäkangas; Jonna K Koponen; Seppo Ylä-Herttuala
Antioxidant gene therapy for cardiovascular disease: current status and future perspectives.
Circulation 2008;117(16):2142-50.
2008: Tiina T Tuomisto; Henri Lumivuori; Emilia Kansanen; Sanna-Kaisa Häkkinen; Mikko Turunen; Johannes V van Thienen; Anton J Horrevoets; Anna-Liisa Levonen; Seppo Ylä-Herttuala
Simvastatin has an anti-inflammatory effect on macrophages via upregulation of an atheroprotective transcription factor, Kruppel-like factor 2.
Cardiovascular research 2008;78(1):175-84.
2008: Johanna P Laakkonen; Minna U Kaikkonen; Paula H A Ronkainen; Teemu Olavi Ihalainen; Einari Niskanen; Maija Häkkinen; Mirka Salminen; Markku S Kulomaa; Seppo Ylä-Herttuala; Kari J Airenne; Maija Vihinen-Ranta
Baculovirus-mediated immediate-early gene expression and nuclear reorganization in human cells.
Cellular microbiology 2008;10(3):667-81.
2008: Helena Viita; Johanna E Markkanen; Emmi Eriksson; Markku Nurminen; Kati Kinnunen; Mohan Babu; Tommi Heikura; Sanna Turpeinen; Svetlana Laidinen; Teemu Takalo; Seppo Ylä-Herttuala
15-lipoxygenase-1 prevents vascular endothelial growth factor A- and placental growth factor-induced angiogenic effects in rabbit skeletal muscles via reduction in growth factor mRNA levels, NO bioactivity, and downregulation of VEGF receptor 2 expression.
Circulation research 2008;102(2):177-84.
2008: Jani Räty; J T Pikkarainen; Thomas Wirth; Seppo Ylä-Herttuala
Gene therapy: the first approved gene-based medicines, molecular mechanisms and clinical indications.
Current molecular pharmacology 2008;1(1):13-23.
2008: Tuomas T Rissanen; Petra Korpisalo; Henna Karvinen; Timo Liimatainen; Svetlana Laidinen; Olli H J Gröhn; Seppo Ylä-Herttuala
High-resolution ultrasound perfusion imaging of therapeutic angiogenesis.
JACC. Cardiovascular imaging 2008;1(1):83-91.
2008: Jani Räty; Hanna P Lesch; Thomas Wirth; Seppo Ylä-Herttuala
Improving safety of gene therapy.
Current drug safety 2008;3(1):46-53.
2007: Jan Hinrich Bräsen; Olli Leppänen; Matias Inkala; Tommi Heikura; Max Levin; Fabian Ahrens; Juha Rutanen; Hubertus Pietsch; David Bergqvist; Anna-Liisa Levonen; Samar Basu; Thomas Zeller; Günter Klöppel; Mikko O Laukkanen; Seppo Ylä-Herttuala
Extracellular superoxide dismutase accelerates endothelial recovery and inhibits in-stent restenosis in stented atherosclerotic Watanabe heritable hyperlipidemic rabbit aorta.
Journal of the American College of Cardiology 2007;50(23):2249-53.
2007: Seppo Ylä-Herttuala; Kari Alitalo
On the relationship of LDL and VEGFR1: not just a family affair.
EMBO reports 2007;8(12):1127-8.
2007: Tuomas Tammela; Anne Saaristo; Tanja Holopainen; Johannes Lyytikkä; Anna Kotronen; Miia Pitkonen; Usama Abo Ramadan; Seppo Ylä-Herttuala; Tatiana V Petrova; Kari Alitalo
Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation.
Nature medicine 2007;13(12):1458-66.
2007: Annina Sipola; Joanna Ilvesaro; Elli A Birr; P Jalovaara; R F Pettersson; Frej Stenbäck; Seppo Ylä-Herttuala; Timo Hautala; Juha Tuukkanen
Endostatin inhibits endochondral ossification.
The journal of gene medicine 2007;9(12):1057-64.
2007: Jonna K Koponen; Tuija Kekarainen; Suvi E Heinonen; Anita Laitinen; Johanna Nystedt; Jarmo Laine; Seppo Ylä-Herttuala
Umbilical cord blood-derived progenitor cells enhance muscle regeneration in mouse hindlimb ischemia model.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(12):2172-7.
2007: Suvi E Heinonen; Pia Leppänen; Ivana Kholová; Henri Lumivuori; Sanna-Kaisa Häkkinen; Fatima Bosch; Markku Laakso; Seppo Ylä-Herttuala
Increased atherosclerotic lesion calcification in a novel mouse model combining insulin resistance, hyperglycemia, and hypercholesterolemia.
Circulation research 2007;101(10):1058-67.
2007: Jani Räty; Timo Liimatainen; Minna Unelma Kaikkonen; Olli H J Gröhn; Kari Juhani Airenne; Kari Jumani Airenne; Seppo Ylä-Herttuala
Non-invasive Imaging in Gene Therapy.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(9):1579-86.
2007: Anssi J Mähönen; Kari J Airenne; Sanna Purola; Erik Peltomaa; Minna U Kaikkonen; Mervi S Riekkinen; Tommi Heikura; Kati Kinnunen; Miia M Roschier; Thomas Wirth; Seppo Ylä-Herttuala
Post-transcriptional regulatory element boosts baculovirus-mediated gene expression in vertebrate cells.
Journal of biotechnology 2007;131(1):1-8.
2007: Satu H Helppolainen; Kirsi P Nurminen; Juha A E Määttä; Katrin K Halling; J Peter Slotte; Tuulia Huhtala; Timo Liimatainen; Seppo Ylä-Herttuala; Kari J Airenne; Ale Närvänen; Janne Jänis; Pirjo Vainiotalo; Jarkko Valjakka; Markku S Kulomaa; Henri R Nordlund
Rhizavidin from Rhizobium etli: the first natural dimer in the avidin protein family.
The Biochemical journal 2007;405(3):397-405.
2007: Tuomas T Rissanen; Seppo Ylä-Herttuala
Current status of cardiovascular gene therapy.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(7):1233-47.
2007: Eija Pirinen; Tiina Kuulasmaa; Marko Pietilä; Sami Heikkinen; Maija Tusa; Paula Itkonen; Susanna Boman; Joanna Skommer; Antti Virkamäki; Esa Hohtola; Mikko I Kettunen; Szabolcs Fatrai; Emilia Kansanen; Suvi Koota; Kirsi Niiranen; Jyrki Parkkinen; Anna-Liisa Levonen; Seppo Ylä-Herttuala; J Kalervo Hiltunen; Leena Alhonen; Ulf Smith; Juhani Jänne; Markku Laakso
Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism.
Molecular and cellular biology 2007;27(13):4953-67.
2007: Maria Wirzenius; Tuomas Tammela; Marko Uutela; Yulong He; Teresa Odorisio; Giovanna Zambruno; Janice A Nagy; Harold F Dvorak; Seppo Ylä-Herttuala; Masabumi Shibuya; Kari Alitalo
Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting.
The Journal of experimental medicine 2007;204(6):1431-40.
2007: Mikko I Kettunen; Alejandra Sierra; M Johanna Närväinen; Piia Valonen; Seppo Ylä-Herttuala; Risto A Kauppinen; Olli H J Gröhn
Low spin-lock field T1 relaxation in the rotating frame as a sensitive MR imaging marker for gene therapy treatment response in rat glioma.
Radiology 2007;243(3):796-803.
2007: Jani Räty; Timo Liimatainen; Tuulia Huhtala; Minna U Kaikkonen; Kari J Airenne; Juhana M Hakumäki; Ale Närvänen; Seppo Ylä-Herttuala
SPECT/CT imaging of baculovirus biodistribution in rat.
Gene therapy 2007;14(12):930-8.
2007: Tuomas Tammela; Yulong He; Johannes Lyytikkä; Michael Jeltsch; Johanna E Markkanen; Katri Pajusola; Seppo Ylä-Herttuala; Kari Alitalo
Distinct architecture of lymphatic vessels induced by chimeric vascular endothelial growth factor-C/vascular endothelial growth factor heparin-binding domain fusion proteins.
Circulation research 2007;100(10):1468-75.
2007: Daoguang Yan; Markku Lehto; Laura Rasilainen; Jari Metso; Christian Ehnholm; Seppo Ylä-Herttuala; Matti Jauhiainen; Vesa M Olkkonen
Oxysterol binding protein induces upregulation of SREBP-1c and enhances hepatic lipogenesis.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(5):1108-14.
2007: Anna-Liisa Levonen; Matias Inkala; Tommi Heikura; Suvi Jauhiainen; Henna-Kaisa Jyrkkänen; Emilia Kansanen; Kirsi Määttä; Elina Romppanen; Päivi Turunen; Juha Rutanen; Seppo Ylä-Herttuala
Nrf2 gene transfer induces antioxidant enzymes and suppresses smooth muscle cell growth in vitro and reduces oxidative stress in rabbit aorta in vivo.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(4):741-7.
2007: Seppo Ylä-Herttuala; Tuomas T Rissanen; Ismo Vajanto; Juha Hartikainen
Vascular endothelial growth factors: biology and current status of clinical applications in cardiovascular medicine.
Journal of the American College of Cardiology 2007;49(10):1015-26.
2007: Ivana Kholová; Suvi Koota; Nina Kaskenpää; Pia Leppänen; Johanna Närväinen; Martin Kavec; Tuomas T Rissanen; Thierry Hazes; Petra Korpisalo; Olli H J Gröhn; Seppo Ylä-Herttuala
Adenovirus-mediated gene transfer of human vascular endothelial growth factor-d induces transient angiogenic effects in mouse hind limb muscle.
Human gene therapy 2007;18(3):232-44.
2007: Outi Rautsi; Saara Lehmusvaara; Tuula Salonen; Katja Häkkinen; Maarit Sillanpää; Tanja Hakkarainen; Sami Heikkinen; Elisa Vähäkangas; Seppo Ylä-Herttuala; Ari E Hinkkanen; Ilkka Julkunen; Jarmo Wahlfors; Riikka Pellinen
Type I interferon response against viral and non-viral gene transfer in human tumor and primary cell lines.
The journal of gene medicine 2007;9(2):122-35.
2007: Anniina Laurema; Satu Lumme; Suvi E Heinonen; Seppo Heinonen; Seppo Ylä-Herttuala
Transduction patterns and efficiencies in rabbit uterine tissues after intraluminal uterine adenovirus administration vary with the reproductive cycle.
Acta obstetricia et gynecologica Scandinavica 2007;86(9):1035-40.
2007: Petru Liuba; Elhadi Hussain Aburawi; Erkki Pesonen; Sture Andersson; Lennart Truedsson; Seppo Ylä-Herttuala; Lars Holmberg
Residual adverse changes in arterial endothelial function and LDL oxidation after a mild systemic inflammation induced by influenza vaccination.
Annals of medicine 2007;39(5):392-9.
2007: Tuomas T Rissanen; Seppo Ylä-Herttuala
[Not Available].
Duodecim; lääketieteellinen aikakauskirja 2007;123(3):306-16.
2007: Johan Back; Esko Kankuri; Tuija Ikonen; Tommi Pätilä; Juha Sinisalo; Mika Laine; Heikki Vapaatalo; Jonna Koponen; Mika Hukkanen; Seppo Ylä-Herttuala; Riitta Alitalo; Markku Kupari; Ari L J Harjula
[Not Available].
Duodecim; lääketieteellinen aikakauskirja 2007;123(4):398-405.
2006: Iina Laitinen; Päivi Marjamäki; Merja Haaparanta; Nina Savisto; Jukka Laine; Sanna L Soini; Ian Wilson; Pia Leppänen; Seppo Ylä-Herttuala; Anne Roivainen; Juhani Knuuti
Non-specific binding of [18F]FDG to calcifications in atherosclerotic plaques: experimental study of mouse and human arteries.
European journal of nuclear medicine and molecular imaging 2006;33(12):1461-7.
2006: Carolin Deiner; Peter L Schwimmbeck; Ina Sabine Koehler; Christoph Loddenkemper; Michel Noutsias; Sigrid Nikol; Heinz-Peter Schultheiss; Seppo Ylä-Herttuala; Klaus Pels
Adventitial VEGF165 gene transfer prevents lumen loss through induction of positive arterial remodeling after PTCA in porcine coronary arteries.
Atherosclerosis 2006;189(1):123-32.
2006: Himadri Roy; Shalini Bhardwaj; Mohan Babu; Ilze Kokina; Sanna Uotila; Tiia Ahtialansaari; Teemu Laitinen; Juhana Hakumaki; Markku Laakso; Karl-Heinz Herzig; Seppo Ylä-Herttuala
VEGF-A, VEGF-D, VEGF receptor-1, VEGF receptor-2, NF-kappaB, and RAGE in atherosclerotic lesions of diabetic Watanabe heritable hyperlipidemic rabbits.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(12):2159-61.
2006: Jani Räty; Timo Liimatainen; Thomas Wirth; Kari J Airenne; Teemu Olavi Ihalainen; Tuulia Huhtala; E Hamerlynck; Maija Vihinen-Ranta; Ale Närvänen; Seppo Ylä-Herttuala; Juhana M Hakumäki
Magnetic resonance imaging of viral particle biodistribution in vivo.
Gene therapy 2006;13(20):1440-6.
2006: Thomas Wirth; Marja Hedman; Kimmo Mäkinen; Hannu Manninen; Arto Immonen; Matti Vapalahti; Seppo Ylä-Herttuala
Safety profile of plasmid/liposomes and virus vectors in clinical gene therapy.
Current drug safety 2006;1(3):253-7.
2006: Seppo Ylä-Herttuala
An update on angiogenic gene therapy: vascular endothelial growth factor and other directions.
Current opinion in molecular therapeutics 2006;8(4):295-300.
2006: Terhi Karpanen; Maria Wirzenius; Taija Mäkinen; Tanja Veikkola; Hidde J Haisma; Marc G Achen; Steven A Stacker; Bronislaw Pytowski; Seppo Ylä-Herttuala; Kari Alitalo
Lymphangiogenic growth factor responsiveness is modulated by postnatal lymphatic vessel maturation.
The American journal of pathology 2006;169(2):708-18.
2006: Kati Kinnunen; Petra Korpisalo; Tuomas T Rissanen; Tommi Heikura; Helena Viita; H Uusitalo; Seppo Ylä-Herttuala
Overexpression of VEGF-A induces neovascularization and increased vascular leakage in rabbit eye after intravitreal adenoviral gene transfer.
Acta physiologica (Oxford, England) 2006;187(4):447-57.
2006: Himadri Roy; Shalini Bhardwaj; Seppo Ylä-Herttuala
Biology of vascular endothelial growth factors.
FEBS letters 2006;580(12):2879-87.
2006: Cecilia Nälsén; Bengt Vessby; Lars Berglund; Matti Uusitupa; Kjeld Hermansen; Gabriele Riccardi; Angela A Rivellese; Len Storlien; Arja Erkkilä; Seppo Ylä-Herttuala; Linda C Tapsell; Samar Basu
Dietary (n-3) fatty acids reduce plasma F2-isoprostanes but not prostaglandin F2alpha in healthy humans.
The Journal of nutrition 2006;136(5):1222-8.
2006: Päivi Turunen; Hanna L Puhakka; Tommi Heikura; Elina Romppanen; Matias Inkala; Olli Leppänen; Seppo Ylä-Herttuala
Extracellular superoxide dismutase with vaccinia virus anti-inflammatory protein 35K or tissue inhibitor of metalloproteinase-1: Combination gene therapy in the treatment of vein graft stenosis in rabbits.
Human gene therapy 2006;17(4):405-14.
2006: Tuomas Mäntylä; Juhana M Hakumäki; Tuulia Huhtala; Ale Närvänen; Seppo Ylä-Herttuala
Targeted magnetic resonance imaging of Scavidin-receptor in human umbilical vein endothelial cells in vitro.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2006;55(4):800-4.
2006: Petri I Mäkinen; Jonna K Koponen; Anna-Mari Kärkkäinen; Tarja M Malm; Kati H Pulkkinen; Jari Koistinaho; Mikko Turunen; Seppo Ylä-Herttuala
Stable RNA interference: comparison of U6 and H1 promoters in endothelial cells and in mouse brain.
The journal of gene medicine 2006;8(4):433-41.
2006: Tommi Pätilä; Tuija Ikonen; Juha Rutanen; Aapo Ahonen; Jyri Lommi; Kimmo Lappalainen; Leena Anneli Krogerus; Leo Ihlberg; Taina A Partanen; Liisa Lähteenoja; Kari Virtanen; Kari Alitalo; Seppo Ylä-Herttuala; Ari L J Harjula
Vascular endothelial growth factor C-induced collateral formation in a model of myocardial ischemia.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2006;25(2):206-13.
2006: Minna U Kaikkonen; Jani Räty; Kari J Airenne; Thomas Wirth; Tommi Heikura; Seppo Ylä-Herttuala
Truncated vesicular stomatitis virus G protein improves baculovirus transduction efficiency in vitro and in vivo.
Gene therapy 2006;13(4):304-12.
2006: Pia Leppänen; Ivana Kholová; Anssi J Mähönen; Kari J Airenne; Suvi Koota; Hannu Mansukoski; Johanna Närväinen; Maria Wirzenius; Leena Alhonen; Juhani Jänne; Kari Alitalo; Seppo Ylä-Herttuala
Short and long-term effects of hVEGF-A(165) in Cre-activated transgenic mice.
PloS one 2006;1():e13.
2005: Tuomas T Rissanen; Petra Korpisalo; Johanna E Markkanen; Timo Liimatainen; Maija-Riitta Ordén; Ivana Kholová; Anna de Goede; Tommi Heikura; Olli H J Gröhn; Seppo Ylä-Herttuala
Blood flow remodels growing vasculature during vascular endothelial growth factor gene therapy and determines between capillary arterialization and sprouting angiogenesis.
Circulation 2005;112(25):3937-46.
2005: Jukka S Luoma; Anu Kareinen; Outi Närvänen; Laura Viitanen; Markku Laakso; Seppo Ylä-Herttuala
Autoantibodies against oxidized LDL are associated with severe chest pain attacks in patients with coronary heart disease.
Free radical biology & medicine 2005;39(12):1660-5.
2005: Himadri Roy; Shalini Bhardwaj; Mohan Babu; Suvi Jauhiainen; Karl-Heinz Herzig; Anna R Bellu; Hidde J Haisma; Peter Carmeliet; Kari Alitalo; Seppo Ylä-Herttuala
Adenovirus-mediated gene transfer of placental growth factor to perivascular tissue induces angiogenesis via upregulation of the expression of endogenous vascular endothelial growth factor-A.
Human gene therapy 2005;16(12):1422-8.
2005: Shalini Bhardwaj; Himadri Roy; Tommi Heikura; Seppo Ylä-Herttuala
VEGF-A, VEGF-D and VEGF-D(DeltaNDeltaC) induced intimal hyperplasia in carotid arteries.
European journal of clinical investigation 2005;35(11):669-76.
2005: Arja T Erkkilä; Outi Närvänen; Seppo Lehto; M I J Uusitupa; Seppo Ylä-Herttuala
Antibodies against oxidized LDL and cardiolipin and mortality in patients with coronary heart disease.
Atherosclerosis 2005;183(1):157-62.
2005: Pia Leppänen; Suvi Koota; Ivana Kholová; Jonna K Koponen; Christina Fieber; Ulf Eriksson; Kari Alitalo; Seppo Ylä-Herttuala
Gene transfers of vascular endothelial growth factor-A, vascular endothelial growth factor-B, vascular endothelial growth factor-C, and vascular endothelial growth factor-D have no effects on atherosclerosis in hypercholesterolemic low-density lipoprotein-receptor/apolipoprotein B48-deficient mice.
Circulation 2005;112(9):1347-52.
2005: Katri Pajusola; Jaana Künnapuu; Sanna Vuorikoski; Jarkko Soronen; Helder André; Teresa Pereira; Petra Korpisalo; Seppo Ylä-Herttuala; Lorenz Poellinger; Kari Alitalo
Stabilized HIF-1alpha is superior to VEGF for angiogenesis in skeletal muscle via adeno-associated virus gene transfer.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(10):1365-7.
2005: Annaleena Heikkilä; Tiina T Tuomisto; Sanna-Kaisa Häkkinen; Leea Keski-Nisula; Seppo Heinonen; Seppo Ylä-Herttuala
Tumor suppressor and growth regulatory genes are overexpressed in severe early-onset preeclampsia--an array study on case-specific human preeclamptic placental tissue.
Acta obstetricia et gynecologica Scandinavica 2005;84(7):679-89.
2005: Rainer Krebs; Jussi M Tikkanen; Antti I Nykänen; Jeanette Wood; Michael Jeltsch; Seppo Ylä-Herttuala; Petri K Koskinen; Karl B Lemström
Dual role of vascular endothelial growth factor in experimental obliterative bronchiolitis.
American journal of respiratory and critical care medicine 2005;171(12):1421-9.
2005: Tiina T Tuomisto; Mervi S Riekkinen; Helena Viita; Anna-Liisa Levonen; Seppo Ylä-Herttuala
Analysis of gene and protein expression during monocyte-macrophage differentiation and cholesterol loading--cDNA and protein array study.
Atherosclerosis 2005;180(2):283-91.
2005: Juha Rutanen; Anna-Mari Turunen; M Teittinen; Tuomas T Rissanen; Tommi Heikura; Jonna K Koponen; Marcin Gruchala; Matias Inkala; Suvi Jauhiainen; Mikko O Hiltunen; Mikko Turunen; Steven A Stacker; Marc G Achen; Seppo Ylä-Herttuala
Gene transfer using the mature form of VEGF-D reduces neointimal thickening through nitric oxide-dependent mechanism.
Gene therapy 2005;12(12):980-7.
2005: Hanna L Puhakka; Päivi Turunen; Marcin Gruchala; Christina A Bursill; Tommi Heikura; Ismo Vajanto; David Greaves; Keith Channons; Seppo Ylä-Herttuala
Effects of vaccinia virus anti-inflammatory protein 35K and TIMP-1 gene transfers on vein graft stenosis in rabbits.
In vivo (Athens, Greece) 2005;19(3):515-21.
2005: Tiina T Tuomisto; Seppo Ylä-Herttuala
What have we learnt about microarray analyses of atherogenesis?
Current opinion in lipidology 2005;16(2):201-5.
2005: Kosuke Katsube; Allen T Bishop; Robert D Simari; Seppo Ylä-Herttuala; Patricia F Friedrich
Vascular endothelial growth factor (VEGF) gene transfer enhances surgical revascularization of necrotic bone.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2005;23(2):469-74.
2005: Päivi Turunen; Hanna L Puhakka; Juha Rutanen; Mikko O Hiltunen; Tommi Heikura; Marcin Gruchala; Seppo Ylä-Herttuala
Intravascular adenovirus-mediated lipoprotein-associated phospholipase A2 gene transfer reduces neointima formation in balloon-denuded rabbit aorta.
Atherosclerosis 2005;179(1):27-33.
2005: Mirka Salminen; Kari J Airenne; Rita Rinnankoski; Jenni Reimari; Outi Välilehto; Johanna Rinne; Sanna Suikkanen; Sari Kukkonen; Seppo Ylä-Herttuala; Markku S Kulomaa; Maija Vihinen-Ranta
Improvement in nuclear entry and transgene expression of baculoviruses by disintegration of microtubules in human hepatocytes.
Journal of virology 2005;79(5):2720-8.
2005: Shalini Bhardwaj; Himadri Roy; T Kärpänen; Y He; Y Hi; Suvi Jauhiainen; Marja Hedman; Kari Alitalo; Seppo Ylä-Herttuala
Periadventitial angiopoietin-1 gene transfer induces angiogenesis in rabbit carotid arteries.
Gene therapy 2005;12(5):388-94.
2005: Johanna E Markkanen; Tuomas T Rissanen; Antti Kivelä; Seppo Ylä-Herttuala
Growth factor-induced therapeutic angiogenesis and arteriogenesis in the heart--gene therapy.
Cardiovascular research 2005;65(3):656-64.
2005: Peter Baluk; Tuomas Tammela; Erin Ator; Natalya Lyubynska; Marc G Achen; Daniel J Hicklin; Michael Jeltsch; Tatiana V Petrova; Bronislaw Pytowski; Steven A Stacker; Seppo Ylä-Herttuala; David G Jackson; Kari Alitalo; Donald M McDonald
Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation.
The Journal of clinical investigation 2005;115(2):247-57.
2005: Tiina T Tuomisto; Bernd R Binder; Seppo Ylä-Herttuala
Genetics, genomics and proteomics in atherosclerosis research.
Annals of medicine 2005;37(5):323-32.
2005: Marika Ruponen; Zanna Hyvönen; Arto Urtti; Seppo Ylä-Herttuala
Nonviral gene delivery methods in cardiovascular diseases.
Methods in molecular medicine 2005;108():315-28.
2005: Jonna K Koponen; Seppo Ylä-Herttuala
[How to make scar tissue in cardiac muscle beat?].
Duodecim; lääketieteellinen aikakauskirja 2005;121(11):1199-201.
2005: Olli H Laitinen; Kari J Airenne; Vesa P Hytönen; Erik Peltomaa; Anssi J Mähönen; Thomas Wirth; Miia M Lind; Kari A Mäkelä; Pyry I Toivanen; Diana Schenkwein; Tommi Heikura; Henri R Nordlund; Markku S Kulomaa; Seppo Ylä-Herttuala
A multipurpose vector system for the screening of libraries in bacteria, insect and mammalian cells and expression in vivo.
Nucleic acids research 2005;33(4):e42.
2004: Vesa P Hytönen; Olli H Laitinen; Tomi T Airenne; Heidi Kidron; Niko J Meltola; Eevaleena J Porkka; Jarno Hörhä; Tiina Paldanius; Juha A E Määttä; Henri R Nordlund; Mark S Johnson; Tiina A Salminen; Kari J Airenne; Seppo Ylä-Herttuala; Markku S Kulomaa
Efficient production of active chicken avidin using a bacterial signal peptide in Escherichia coli.
The Biochemical journal 2004;384(Pt 2):385-90.
2004: Seppo Ylä-Herttuala; Johanna E Markkanen; Tuomas T Rissanen
Gene therapy for ischemic cardiovascular diseases: some lessons learned from the first clinical trials.
Trends in cardiovascular medicine 2004;14(8):295-300.
2004: Arto Immonen; Matti Vapalahti; Kristiina Tyynelä; Heleena Hurskainen; Anu-Maaria Sandmair; Ritva Vanninen; Gillian Langford; Neil Murray; Seppo Ylä-Herttuala
AdvHSV-tk gene therapy with intravenous ganciclovir improves survival in human malignant glioma: a randomised, controlled study.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;10(5):967-72.
2004: Elhadi Hussain Aburawi; Petru Liuba; Erkki Pesonen; Seppo Ylä-Herttuala; Sture Sjöblad
Acute respiratory viral infections aggravate arterial endothelial dysfunction in children with type 1 diabetes.
Diabetes care 2004;27(11):2733-5.
2004: Tatiana V Petrova; Terhi Karpanen; Camilla Norrmén; Russell H Mellor; Tomoki Tamakoshi; David N Finegold; Robert E Ferrell; Dontscho Kerjaschki; Peter Mortimer; Seppo Ylä-Herttuala; Naoyuki Miura; Kari Alitalo
Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis.
Nature medicine 2004;10(9):974-81.
2004: Päivi Turunen; Johanna Jalkanen; Tommi Heikura; Hanna L Puhakka; Jouni Karppi; Kristiina Nyyssönen; Seppo Ylä-Herttuala
Adenovirus-mediated gene transfer of Lp-PLA2 reduces LDL degradation and foam cell formation in vitro.
Journal of lipid research 2004;45(9):1633-9.
2004: Anssi J Mähönen; Kari J Airenne; Miia M Lind; Hanna P Lesch; Seppo Ylä-Herttuala
Optimized self-excising Cre-expression cassette for mammalian cells.
Biochemical and biophysical research communications 2004;320(2):366-71.
2004: Tiina T Tuomisto; Tuomas T Rissanen; Ismo Vajanto; Anna Korkeela; Juha Rutanen; Seppo Ylä-Herttuala
HIF-VEGF-VEGFR-2, TNF-alpha and IGF pathways are upregulated in critical human skeletal muscle ischemia as studied with DNA array.
Atherosclerosis 2004;174(1):111-20.
2004: Marcin Gruchała; Shalini Bhardwaj; Katri Pajusola; Himadri Roy; Tuomas T Rissanen; Ilze Kokina; Ivana Kholová; Johanna E Markkanen; Juha Rutanen; Tommi Heikura; Kari Alitalo; Hansruedi Büeler; Seppo Ylä-Herttuala
Gene transfer into rabbit arteries with adeno-associated virus and adenovirus vectors.
The journal of gene medicine 2004;6(5):545-54.
2004: Kaisa Koskinen; Petri J Vainio; David J Smith; Marjo Pihlavisto; Seppo Ylä-Herttuala; Sirpa Jalkanen; Marko Salmi
Granulocyte transmigration through the endothelium is regulated by the oxidase activity of vascular adhesion protein-1 (VAP-1).
Blood 2004;103(9):3388-95.
2004: Hanna Kankkonen; Elisa Vähäkangas; Robert Marr; Timo Pakkanen; Anniina Laurema; Pia Leppänen; Johanna Jalkanen; Inder M Verma; Seppo Ylä-Herttuala
Long-term lowering of plasma cholesterol levels in LDL-receptor-deficient WHHL rabbits by gene therapy.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;9(4):548-56.
2004: Piia Valonen; Kimmo Kristian Lehtimäki; Tuula H Väisänen; Mikko I Kettunen; Olli H J Gröhn; Seppo Ylä-Herttuala; Risto A Kauppinen
Water diffusion in a rat glioma during ganciclovir-thymidine kinase gene therapy-induced programmed cell death in vivo: correlation with cell density.
Journal of magnetic resonance imaging : JMRI 2004;19(4):389-96.
2004: Hanna Tuhkanen; Maarit Anttila; Veli-Matti Kosma; Seppo Ylä-Herttuala; Seppo Heinonen; Arja Kuronen; Matti Juhola; Raija Tammi; Markku Tammi; Arto Mannermaa
Genetic alterations in the peritumoral stromal cells of malignant and borderline epithelial ovarian tumors as indicated by allelic imbalance on chromosome 3p.
International journal of cancer. Journal international du cancer 2004;109(2):247-52.
2004: Olli Leppänen; Juha Rutanen; Mikko O Hiltunen; Tuomas T Rissanen; Mikko Turunen; Tobias Sjöblom; Josef Brüggen; Gudrun Bäckström; Marianne Carlsson; Elisabeth Buchdunger; David Bergqvist; Kari Alitalo; Carl-Henrik Heldin; Arne Ostman; Seppo Ylä-Herttuala
Oral imatinib mesylate (STI571/gleevec) improves the efficacy of local intravascular vascular endothelial growth factor-C gene transfer in reducing neointimal growth in hypercholesterolemic rabbits.
Circulation 2004;109(9):1140-6.
2004: Juha Rutanen; Tuomas T Rissanen; Johanna E Markkanen; Marcin Gruchala; Päivi Silvennoinen; Antti Kivelä; Antti Hedman; Marja Hedman; Tommi Heikura; Maija-Riitta Ordén; Steven A Stacker; Marc G Achen; Juha Hartikainen; Seppo Ylä-Herttuala
Adenoviral catheter-mediated intramyocardial gene transfer using the mature form of vascular endothelial growth factor-D induces transmural angiogenesis in porcine heart.
Circulation 2004;109(8):1029-35.
2004: Hanna Kankkonen; Mikko Turunen; Mikko O Hiltunen; Pauliina Lehtolainen; Jonna K Koponen; Pia Leppänen; Anna-Mari Turunen; Seppo Ylä-Herttuala
Feline immunodeficiency virus and retrovirus-mediated adventitial ex vivo gene transfer to rabbit carotid artery using autologous vascular smooth muscle cells.
Journal of molecular and cellular cardiology 2004;36(3):333-41.
2004: Jani Räty; Kari J Airenne; Ari T Marttila; Varpu Marjomäki; Vesa P Hytönen; Pauliina Lehtolainen; Olli H Laitinen; Anssi J Mähönen; Markku S Kulomaa; Seppo Ylä-Herttuala
Enhanced gene delivery by avidin-displaying baculovirus.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;9(2):282-91.
2004: Antje Banning; Kerstin Schnurr; Gaby-Fleur Böl; Dagmar Kupper; Katrin Müller-Schmehl; Helena Viita; Seppo Ylä-Herttuala; Regina Brigelius-Flohé
Inhibition of basal and interleukin-1-induced VCAM-1 expression by phospholipid hydroperoxide glutathione peroxidase and 15-lipoxygenase in rabbit aortic smooth muscle cells.
Free radical biology & medicine 2004;36(2):135-44.
2004: Tuomas T Rissanen; Juha Rutanen; Seppo Ylä-Herttuala
Gene transfer for therapeutic vascular growth in myocardial and peripheral ischemia.
Advances in genetics 2004;52():117-64.
2004: Marcin Gruchala; Himadri Roy; Shalini Bhardwaj; Seppo Ylä-Herttuala
Gene therapy for cardiovascular diseases.
Current pharmaceutical design 2004;10(4):407-23.
2004: Anniina Laurema; Kari Vanamo; Annaleena Heikkilä; Mervi Riekkinen; Seppo Heinonen; Seppo Ylä-Herttuala
Fetal membranes act as a barrier for adenoviruses: gene transfer into exocoelomic cavity of rat fetuses does not affect cells in the fetus.
American journal of obstetrics and gynecology 2004;190(1):264-7.
2003: Seppo Ylä-Herttuala
Novel targeting of biotinylated compounds to local tissues with avidin-lipoprotein receptor fusion protein.
Discovery medicine 2003;3(19):47-8.
2003: Johanna Jalkanen; Pia Leppänen; Katri Pajusola; Outi Närvänen; Anssi J Mähönen; Elisa Vähäkangas; David Greaves; Hansruedi Büeler; Seppo Ylä-Herttuala
Adeno-associated virus-mediated gene transfer of a secreted decoy human macrophage scavenger receptor reduces atherosclerotic lesion formation in LDL receptor knockout mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;8(6):903-10.
2003: Pauliina Lehtolainen; Thomas Wirth; A K Taskinen; Petri Lehenkari; Olli Leppänen; M Lappalainen; Kalevi Juhani Pulkkanen; Ari T Marttila; Varpu Marjomäki; Kari J Airenne; Michael Horton; Markku S Kulomaa; Seppo Ylä-Herttuala
Targeting of biotinylated compounds to its target tissue using a low-density lipoprotein receptor-avidin fusion protein.
Gene therapy 2003;10(25):2090-7.
2003: Tiina T Tuomisto; Anna Korkeela; Juha Rutanen; Helena Viita; Jan Hinrich Bräsen; Mervi S Riekkinen; Tuomas T Rissanen; Kari Karkola; Zsolt Kiraly; Konrad Kölble; Seppo Ylä-Herttuala
Gene expression in macrophage-rich inflammatory cell infiltrates in human atherosclerotic lesions as studied by laser microdissection and DNA array: overexpression of HMG-CoA reductase, colony stimulating factor receptors, CD11A/CD18 integrins, and interleukin receptors.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(12):2235-40.
2003: Olli H J Gröhn; Piia Valonen; Kimmo Kristian Lehtimäki; Tuula H Väisänen; Mikko I Kettunen; Seppo Ylä-Herttuala; Risto A Kauppinen; Michael Garwood
Novel magnetic resonance imaging contrasts for monitoring response to gene therapy in rat glioma.
Cancer research 2003;63(22):7571-4.
2003: Kimmo Kristian Lehtimäki; Piia Valonen; Julian L Griffin; Tuula H Väisänen; Olli H J Gröhn; Mikko I Kettunen; Jouko Vepsäläinen; Seppo Ylä-Herttuala; Jeremy Nicholson; Risto A Kauppinen
Metabolite changes in BT4C rat gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death as studied by 1H NMR spectroscopy in vivo, ex vivo, and in vitro.
The Journal of biological chemistry 2003;278(46):45915-23.
2003: Neal S Kleiman; Nirav C Patel; Keith B Allen; Michael Simons; Seppo Ylä-Herttuala; Elaine Griffin; Victor J Dzau
Evolving revascularization approaches for myocardial ischemia.
The American journal of cardiology 2003;92(9B):9N-17N.
2003: Sari P Kukkonen; Kari J Airenne; Varpu Marjomäki; Olli H Laitinen; Pauliina Lehtolainen; Pasi Kankaanpää; Anssi J Mähönen; Jani Räty; Henri R Nordlund; Christian Oker-Blom; Markku S Kulomaa; Seppo Ylä-Herttuala
Baculovirus capsid display: a novel tool for transduction imaging.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;8(5):853-62.
2003: Pasi Lampela; Marko Huotari; Anu Harjula; Lasse Oinonen; Mart Ustav; Seppo Ylä-Herttuala; Pekka T Männistö; Atso Raasmaja
Production of functional recombinant tyrosine hydroxylase by the BPV-1 expression plasmids in the cell cultures.
Plasmid 2003;50(3):230-5.
2003: Seppo Ylä-Herttuala
Percutaneous transcoronary venous access for cellular cardiomyoplasty.
Lancet 2003;362(9392):1252.
2003: Shalini Bhardwaj; Himadri Roy; Marcin Gruchala; Helena Viita; Ivana Kholova; Ilze Kokina; Marc G Achen; Steven A Stacker; Marja Hedman; Kari Alitalo; Seppo Ylä-Herttuala
Angiogenic responses of vascular endothelial growth factors in periadventitial tissue.
Human gene therapy 2003;14(15):1451-62.
2003: Juha Rutanen; Pia Leppänen; Tiina T Tuomisto; Tuomas T Rissanen; Mikko O Hiltunen; Ismo Vajanto; Mari Niemi; Tomi P Häkkinen; Kari Karkola; Steven A Stacker; Marc G Achen; Kari Alitalo; Seppo Ylä-Herttuala
Vascular endothelial growth factor-D expression in human atherosclerotic lesions.
Cardiovascular research 2003;59(4):971-9.
2003: Mikko O Hiltunen; Seppo Ylä-Herttuala
DNA methylation, smooth muscle cells, and atherogenesis.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(10):1750-3.
2003: Kari J Airenne; Erik Peltomaa; Vesa P Hytönen; Olli H Laitinen; Seppo Ylä-Herttuala
Improved generation of recombinant baculovirus genomes in Escherichia coli.
Nucleic acids research 2003;31(17):e101.
2003: Johanna Jalkanen; Pia Leppänen; Outi Närvänen; David Greaves; Seppo Ylä-Herttuala
Adenovirus-mediated gene transfer of a secreted decoy human macrophage scavenger receptor (SR-AI) in LDL receptor knock-out mice.
Atherosclerosis 2003;169(1):95-103.
2003: Tatu Tarkka; Annina Sipola; Timo Jämsä; Ylermi Soini; Seppo Ylä-Herttuala; Juha Tuukkanen; Timo Hautala
Adenoviral VEGF-A gene transfer induces angiogenesis and promotes bone formation in healing osseous tissues.
The journal of gene medicine 2003;5(7):560-6.
2003: Julian L Griffin; Kimmo Kristian Lehtimäki; Piia Valonen; Olli H J Gröhn; Mikko I Kettunen; Seppo Ylä-Herttuala; Asla Pitkänen; Jeremy K Nicholson; Risto A Kauppinen
Assignment of 1H nuclear magnetic resonance visible polyunsaturated fatty acids in BT4C gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death.
Cancer research 2003;63(12):3195-201.
2003: Marja Hedman; Juha Hartikainen; Mikko Syvänne; Joachim Stjernvall; Antti Hedman; Antti Kivelä; Esko Vanninen; Hanna Mussalo; Esa Kauppila; Sakari Simula; Outi Närvänen; Arto Rantala; Keijo Peuhkurinen; Markku S Nieminen; Markku Laakso; Seppo Ylä-Herttuala
Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: phase II results of the Kuopio Angiogenesis Trial (KAT).
Circulation 2003;107(21):2677-83.
2003: Seppo Ylä-Herttuala; Kari Alitalo
Gene transfer as a tool to induce therapeutic vascular growth.
Nature medicine 2003;9(6):694-701.
2003: Mikko O Hiltunen; Markku Ruuskanen; Jouni Huuskonen; Anssi Juhani Mähönen; Mari Ahonen; Juha Rutanen; Veli-Matti Kosma; Anitta Mahonen; Heikki Kröger; Seppo Ylä-Herttuala
Adenovirus-mediated VEGF-A gene transfer induces bone formation in vivo.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(9):1147-9.
2003: Tuomas T Rissanen; Johanna E Markkanen; Marcin Gruchala; Tommi Heikura; Antti Puranen; Mikko I Kettunen; Ivana Kholová; Risto A Kauppinen; Marc G Achen; Steven A Stacker; Kari Alitalo; Seppo Ylä-Herttuala
VEGF-D is the strongest angiogenic and lymphangiogenic effector among VEGFs delivered into skeletal muscle via adenoviruses.
Circulation research 2003;92(10):1098-106.
2003: Anniina Laurema; Annaleena Heikkilä; Leea Keski-Nisula; Tommi Heikura; P Lehtolainen; Hannu Manninen; Tiina T Tuomisto; Seppo Heinonen; Seppo Ylä-Herttuala
Transfection of oocytes and other types of ovarian cells in rabbits after direct injection into uterine arteries of adenoviruses and plasmid/liposomes.
Gene therapy 2003;10(7):580-4.
2003: Antti I Nykänen; Rainer Krebs; Anne Saaristo; Päivi Turunen; Kari Alitalo; Seppo Ylä-Herttuala; Petri K Koskinen; Karl B Lemström
Angiopoietin-1 protects against the development of cardiac allograft arteriosclerosis.
Circulation 2003;107(9):1308-14.
2003: Petru Liuba; Erkki Pesonen; Ilari Paakkari; satish c batra; Leif Andersen; Anders Forslid; Seppo Ylä-Herttuala; Kenneth Persson; Torkel Wadström; Xin Wang; Ricardo Laurini
Co-infection with Chlamydia pneumoniae and Helicobacter pylori results in vascular endothelial dysfunction and enhanced VCAM-1 expression in apoE-knockout mice.
Journal of vascular research 2003;40(2):115-22.
2003: Petru Liuba; Jerker Persson; Jukka Luoma; Seppo Ylä-Herttuala; Erkki Pesonen
Acute infections in children are accompanied by oxidative modification of LDL and decrease of HDL cholesterol, and are followed by thickening of carotid intima-media.
European heart journal 2003;24(6):515-21.
2003: Jonna K Koponen; Hanna Kankkonen; J Kannasto; Thomas Wirth; Wolfgang Hillen; H Bujard; Seppo Ylä-Herttuala
Doxycycline-regulated lentiviral vector system with a novel reverse transactivator rtTA2S-M2 shows a tight control of gene expression in vitro and in vivo.
Gene therapy 2003;10(6):459-66.
2003: Leo Niskanen; Virpi Lindi; Arja T Erkkilä; Katariina Sivenius; Jukka S Luoma; Seppo Ylä-Herttuala; Markku Laakso; M I J Uusitupa
Association of the PRO12ALA polymorphism of the PPAR-gamma2 gene with oxidized low-density lipoprotein and cardiolipin autoantibodies in nondiabetic and type 2 diabetic subjects.
Metabolism: clinical and experimental 2003;52(2):213-7.
2003: Seppo Ylä-Herttuala
Angiogenesis clinical trials.
Ernst Schering Research Foundation workshop 2003;(43):19-23.
2003: Maija Kossila; Jussi Pihlajamäki; Päivi Kärkkäinen; Raija Miettinen; Päivi Kekäläinen; Ilkka Vauhkonen; Seppo Ylä-Herttuala; Markku Laakso
Promoter polymorphisms -359T/C and -303A/G of the catalytic subunit p110beta gene of human phosphatidylinositol 3-kinase are not associated with insulin secretion or insulin sensitivity in finnish subjects.
Diabetes care 2003;26(1):179-82.
2003: Jan Hinrich Bräsen; Tomi Häkkinen; Ernst Malle; Ulrike Beisiegel; Seppo Ylä-Herttuala
Patterns of oxidized epitopes, but not NF-kappa B expression, change during atherogenesis in WHHL rabbits.
Atherosclerosis 2003;166(1):13-21.
2003: Tuomas T Rissanen; Johanna E Markkanen; Katja Arve; Juha Rutanen; Mikko I Kettunen; Ismo Vajanto; Suvi Jauhiainen; Linda Cashion; Marcin Gruchala; Outi Närvänen; Pekka Taipale; Risto A Kauppinen; Gabor M Rubanyi; Seppo Ylä-Herttuala
Fibroblast growth factor 4 induces vascular permeability, angiogenesis and arteriogenesis in a rabbit hindlimb ischemia model.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(1):100-2.
2002: Pauliina Lehtolainen; Kristiina Tyynelä; J Kannasto; Kari J Airenne; Seppo Ylä-Herttuala
Baculoviruses exhibit restricted cell type specificity in rat brain: a comparison of baculovirus- and adenovirus-mediated intracerebral gene transfer in vivo.
Gene therapy 2002;9(24):1693-9.
2002: Juha Rutanen; Hanna L Puhakka; Seppo Ylä-Herttuala
Post-intervention vessel remodeling.
Gene therapy 2002;9(22):1487-91.
2002: Katri Pajusola; Marcin Gruchala; Hana Joch; Thomas F Lüscher; Seppo Ylä-Herttuala; Hansruedi Büeler
Cell-type-specific characteristics modulate the transduction efficiency of adeno-associated virus type 2 and restrain infection of endothelial cells.
Journal of virology 2002;76(22):11530-40.
2002: Kristiina Tyynelä; Anu-Maaria Sandmair; Mikko P Turunen; Ritva Vanninen; Pauli Vainio; Risto A Kauppinen; Risto Johansson; Matti Vapalahti; Seppo Ylä-Herttuala
Adenovirus-mediated herpes simplex virus thymidine kinase gene therapy in BT4C rat glioma model.
Cancer gene therapy 2002;9(11):917-24.
2002: Mikko O Hiltunen; Tiina T Tuomisto; Mari Niemi; Jan Hinrich Bräsen; Tuomas T Rissanen; Petri Törönen; Ismo Vajanto; Seppo Ylä-Herttuala
Changes in gene expression in atherosclerotic plaques analyzed using DNA array.
Atherosclerosis 2002;165(1):23-32.
2002: Anne Saaristo; Tanja Veikkola; Tuomas Tammela; Berndt Enholm; Marika J Karkkainen; Katri Pajusola; Hansruedi Bueler; Seppo Ylä-Herttuala; Kari Alitalo
Lymphangiogenic gene therapy with minimal blood vascular side effects.
The Journal of experimental medicine 2002;196(6):719-30.
2002: Tatiana V Petrova; Taija Mäkinen; Tomi Mäkelä; Janna Saarela; Ismo Virtanen; Robert E Ferrell; David N Finegold; Dontscho Kerjaschki; Seppo Ylä-Herttuala; Kari Alitalo
Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor.
The EMBO journal 2002;21(17):4593-9.
2002: Mikko Turunen; Hanna L Puhakka; Jonna K Koponen; Mikko O Hiltunen; Juha Rutanen; Olli Leppänen; Anna-Mari Turunen; Ale Närvänen; Andrew C Newby; Andrew H Baker; Seppo Ylä-Herttuala
Peptide-retargeted adenovirus encoding a tissue inhibitor of metalloproteinase-1 decreases restenosis after intravascular gene transfer.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(3):306-12.
2002: Jan Hinrich Bräsen; Kai Koenig; Heiko Bach; Anatol Kontush; Helmut Heinle; Paul K Witting; Seppo Ylä-Herttuala; Roland Stocker; Ulrike Beisiegel
Comparison of the effects of alpha-tocopherol, ubiquinone-10 and probucol at therapeutic doses on atherosclerosis in WHHL rabbits.
Atherosclerosis 2002;163(2):249-59.
2002: Ismo Vajanto; Tuomas T Rissanen; Juha Rutanen; Mikko O Hiltunen; Tiina T Tuomisto; Katja Arve; Outi Närvänen; Hannu Manninen; Heikki T Räsänen; Maritta Hippeläinen; Esko Alhava; Seppo Ylä-Herttuala
Evaluation of angiogenesis and side effects in ischemic rabbit hindlimbs after intramuscular injection of adenoviral vectors encoding VEGF and LacZ.
The journal of gene medicine 2002;4(4):371-80.
2002: Kimmo Mäkinen; Hannu Manninen; Marja Hedman; Pekka J Matsi; Hanna Mussalo; Esko Alhava; Seppo Ylä-Herttuala
Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: a randomized, placebo-controlled, double-blinded phase II study.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(1):127-33.
2002: Anne Saaristo; Tanja Veikkola; Berndt Enholm; Maija Hytönen; Johanna Arola; Katri Pajusola; Païvi Turunen; Michael Jeltsch; Marika J Karkkainen; Dontscho Kerjaschki; Hansruedi Bueler; Seppo Ylä-Herttuala; Kari Alitalo
Adenoviral VEGF-C overexpression induces blood vessel enlargement, tortuosity, and leakiness but no sprouting angiogenesis in the skin or mucous membranes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(9):1041-9.
2002: Karl B Lemström; Rainer Krebs; Antti I Nykänen; Jussi M Tikkanen; Roope K Sihvola; Eva M Aaltola; Pekka Häyry; Jeanette Wood; Kari Alitalo; Seppo Ylä-Herttuala; Petri K Koskinen
Vascular endothelial growth factor enhances cardiac allograft arteriosclerosis.
Circulation 2002;105(21):2524-30.
2002: Annaleena Heikkilä; Paivi Myllynen; Leea Keski-Nisula; Seppo Heinonen; Kirsi Vähäkangas; Seppo Ylä-Herttuala
Gene transfer to human placenta ex vivo: a novel application of dual perfusion of human placental cotyledon.
American journal of obstetrics and gynecology 2002;186(5):1046-51.
2002: Juhana M Hakumäki; Olli H J Gröhn; Kristiina Tyynelä; Piia Valonen; Seppo Ylä-Herttuala; Risto A Kauppinen
Early gene therapy-induced apoptotic response in BT4C gliomas by magnetic resonance relaxation contrast T1 in the rotating frame.
Cancer gene therapy 2002;9(4):338-45.
2002: Tuomas T Rissanen; Ismo Vajanto; Mikko O Hiltunen; Juha Rutanen; Mikko I Kettunen; Mari Niemi; Pia Leppänen; Mikko Turunen; Johanna E Markkanen; Katja Arve; Esko Alhava; Risto A Kauppinen; Seppo Ylä-Herttuala
Expression of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 (KDR/Flk-1) in ischemic skeletal muscle and its regeneration.
The American journal of pathology 2002;160(4):1393-403.
2002: Pauliina Lehtolainen; Anna Taskinen; Jari A Laukkanen; Kari J Airenne; Sanna Heino; Maarit Lappalainen; Kirsi Ojala; Varpu Marjomäki; John F Martin; Markku S Kulomaa; Seppo Ylä-Herttuala
Cloning and characterization of Scavidin, a fusion protein for the targeted delivery of biotinylated molecules.
The Journal of biological chemistry 2002;277(10):8545-50.
2002: Pasi Lampela; Johanna Räisänen; Pekka T Männistö; Seppo Ylä-Herttuala; Atso Raasmaja
The use of low-molecular-weight PEIs as gene carriers in the monkey fibroblastoma and rabbit smooth muscle cell cultures.
The journal of gene medicine 2002;4(2):205-14.
2002: Jonna K Koponen; Anna-Mari Turunen; Seppo Ylä-Herttuala
Escherichia coli DNA contamination in AmpliTaq Gold polymerase interferes with TaqMan analysis of lacZ.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(3):220-2.
2002: Mikko O Hiltunen; Mikko Turunen; Tomi P Häkkinen; Juha Rutanen; Marja Hedman; Kimmo Mäkinen; Anna-Mari Turunen; Katriina Aalto-Setälä; Seppo Ylä-Herttuala
DNA hypomethylation and methyltransferase expression in atherosclerotic lesions.
Vascular medicine (London, England) 2002;7(1):5-11.
2002: Juha Rutanen; Johanna E Markkanen; Seppo Ylä-Herttuala
Gene therapy for restenosis: current status.
Drugs 2002;62(11):1575-85.
2002: Jari A Laukkanen; Seppo Ylä-Herttuala
Cloning and characterization of soluble decoy receptors.
Methods in enzymology 2002;353():337-45.
2002: Jari A Laukkanen; Seppo Ylä-Herttuala
Genes involved in atherosclerosis.
Experimental nephrology 2002;10(2):150-63.
2002: Mikko O Hiltunen; Mikko Turunen; Seppo Ylä-Herttuala
Gene therapy methods in cardiovascular diseases.
Methods in enzymology 2002;346():311-20.
2002: Maija Kossila; Suvi Jauhiainen; Mikko O Laukkanen; Pauliina Lehtolainen; Maiju Jääskeläinen; Päivi Turunen; Sami Loimas; Jarmo Wahlfors; Seppo Ylä-Herttuala
Improvement in adenoviral gene transfer efficiency after preincubation at +37 degrees C in vitro and in vivo.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(1):87-93.
2001: Jan Hinrich Bräsen; Antti Kivelä; Kerstin Röser; Tuomas T Rissanen; Mari Niemi; F C Luft; K Donath; Seppo Ylä-Herttuala
Angiogenesis, vascular endothelial growth factor and platelet-derived growth factor-BB expression, iron deposition, and oxidation-specific epitopes in stented human coronary arteries.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(11):1720-6.
2001: Outi Närvänen; Arja T Erkkilä; Seppo Ylä-Herttuala
Evaluation and characterization of EIA measuring autoantibodies against oxidized LDL.
Free radical biology & medicine 2001;31(6):769-77.
2001: Marie-Louise Sentman; Thomas Brännström; S Westerlund; Mikko O Laukkanen; Seppo Ylä-Herttuala; Samar Basu; Stefan L Marklund
Extracellular superoxide dismutase deficiency and atherosclerosis in mice.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(9):1477-82.
2001: Tuomas T Rissanen; Ismo Vajanto; Seppo Ylä-Herttuala
Gene therapy for therapeutic angiogenesis in critically ischaemic lower limb - on the way to the clinic.
European journal of clinical investigation 2001;31(8):651-66.
2001: Mikko O Laukkanen; Pia Leppänen; Päivi Turunen; Elina Porkkala-Sarataho; Jukka T Salonen; Seppo Ylä-Herttuala
Gene transfer of extracellular superoxide dismutase to atherosclerotic mice.
Antioxidants & redox signaling 2001;3(3):397-402.
2001: Annaleena Heikkilä; Mikko O Hiltunen; Mikko Turunen; Leea Keski-Nisula; Anna-Mari Turunen; Heikki T Räsänen; Tuomas T Rissanen; Veli-Matti Kosma; Hannu Manninen; Seppo Heinonen; Seppo Ylä-Herttuala
Angiographically guided utero-placental gene transfer in rabbits with adenoviruses, plasmid/liposomes and plasmid/polyethyleneimine complexes.
Gene therapy 2001;8(10):784-8.
2001: Pia Leppänen; Jonna K Koponen; Mikko Turunen; Timo Pakkanen; Seppo Ylä-Herttuala
Optimized in situ PCR method for the detection of gene transfer vector in histological sections.
The journal of gene medicine 2001;3(2):173-8.
2001: Terhi Karpanen; Mikala Egeblad; Marika J Karkkainen; Hajime Kubo; Seppo Ylä-Herttuala; Marja Jäättelä; Kari Alitalo
Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth.
Cancer research 2001;61(5):1786-90.
2001: Taija Mäkinen; Lotta Jussila; Tanja Veikkola; Terhi Karpanen; Mikko I Kettunen; Kalevi Juhani Pulkkanen; Raili Kauppinen; David G Jackson; Hajime Kubo; S Nishikawa; Seppo Ylä-Herttuala; Kari Alitalo
Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3.
Nature medicine 2001;7(2):199-205.
2001: Timo P Hiltunen; Peter J Gough; David Greaves; S Gordon; Seppo Ylä-Herttuala
Rabbit atherosclerotic lesions express scavenger receptor AIII mRNA, a naturally occurring splice variant that encodes a non-functional, dominant negative form of the macrophage scavenger receptor.
Atherosclerosis 2001;154(2):415-9.
2001: Juha Rutanen; Tuomas T Rissanen; Antti Kivelä; Ismo Vajanto; Seppo Ylä-Herttuala
Clinical applications of vascular gene therapy.
Current cardiology reports 2001;3(1):29-36.
2000: Anu-Maaria Sandmair; Sami Loimas; P Puranen; Arto Immonen; Maija Kossila; Matti Puranen; Heleena Hurskainen; Kristiina Tyynelä; Mikko P Turunen; Ritva Vanninen; Pauliina Lehtolainen; Leo Paljärvi; Risto Johansson; Matti Vapalahti; Seppo Ylä-Herttuala
Thymidine kinase gene therapy for human malignant glioma, using replication-deficient retroviruses or adenoviruses.
Human gene therapy 2000;11(16):2197-205.
2000: Mikko O Hiltunen; Mikko Turunen; Anna-Mari Turunen; Tuomas T Rissanen; M Laitinen; Veli-Matti Kosma; Seppo Ylä-Herttuala
Biodistribution of adenoviral vector to nontarget tissues after local in vivo gene transfer to arterial wall using intravascular and periadventitial gene delivery methods.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(14):2230-6.
2000: Mikko O Hiltunen; M Laitinen; Mikko Turunen; Michael Jeltsch; Juha Hartikainen; Tuomas T Rissanen; Jari A Laukkanen; Mari Niemi; Maija Kossila; Tomi P Häkkinen; Antti Kivelä; Berndt Enholm; Hannu Mansukoski; Anna-Mari Turunen; Kari Alitalo; Seppo Ylä-Herttuala
Intravascular adenovirus-mediated VEGF-C gene transfer reduces neointima formation in balloon-denuded rabbit aorta.
Circulation 2000;102(18):2262-8.
2000: Tomi P Häkkinen; Kari Karkola; Seppo Ylä-Herttuala
Macrophages, smooth muscle cells, endothelial cells, and T-cells express CD40 and CD40L in fatty streaks and more advanced human atherosclerotic lesions. Colocalization with epitopes of oxidized low-density lipoprotein, scavenger receptor, and CD16 (Fc gammaRIII).
Virchows Archiv : an international journal of pathology 2000;437(4):396-405.
2000: Maija Kossila; M Sinkovic; Päivi Kärkkäinen; Mikko O Laukkanen; Raija Miettinen; J Rissanen; Päivi Kekäläinen; Johanna Kuusisto; Seppo Ylä-Herttuala; Markku Laakso
Gene encoding the catalytic subunit p110beta of human phosphatidylinositol 3-kinase: cloning, genomic structure, and screening for variants in patients with type 2 diabetes.
Diabetes 2000;49(10):1740-3.
2000: Regina Brigelius-Flohé; S Maurer; K Lötzer; Gaby-Fleur Böl; Hanna Kankkonen; Pauliina Lehtolainen; Helena Viita; Seppo Ylä-Herttuala
Overexpression of PHGPx inhibits hydroperoxide-induced oxidation, NFkappaB activation and apoptosis and affects oxLDL-mediated proliferation of rabbit aortic smooth muscle cells.
Atherosclerosis 2000;152(2):307-16.
2000: Marja Hedman; Seppo Ylä-Herttuala
Gene therapy for the treatment of peripheral vascular disease and coronary artery disease.
Drugs of today (Barcelona, Spain : 1998) 2000;36(9):609-17.
2000: Kari J Airenne; Mikko O Hiltunen; Mikko Turunen; Anna-Mari Turunen; Olli H Laitinen; Markku S Kulomaa; Seppo Ylä-Herttuala
Baculovirus-mediated periadventitial gene transfer to rabbit carotid artery.
Gene therapy 2000;7(17):1499-504.
2000: Mikko O Laukkanen; Pauliina Lehtolainen; Päivi Turunen; S Aittomäki; P Oikari; Stefan L Marklund; Seppo Ylä-Herttuala
Rabbit extracellular superoxide dismutase: expression and effect on LDL oxidation.
Gene 2000;254(1-2):173-9.
2000: Jari A Laukkanen; Pauliina Lehtolainen; Peter J Gough; David Greaves; S Gordon; Seppo Ylä-Herttuala
Adenovirus-mediated gene transfer of a secreted form of human macrophage scavenger receptor inhibits modified low-density lipoprotein degradation and foam-cell formation in macrophages.
Circulation 2000;101(10):1091-6.
2000: Anu-Maaria Sandmair; Mikko P Turunen; Kristiina Tyynelä; Sami Loimas; Pauli Vainio; Ritva Vanninen; Matti Vapalahti; R Bjerkvig; Juhani Jänne; Seppo Ylä-Herttuala
Herpes simplex virus thymidine kinase gene therapy in experimental rat BT4C glioma model: effect of the percentage of thymidine kinase-positive glioma cells on treatment effect, survival time, and tissue reactions.
Cancer gene therapy 2000;7(3):413-21.
2000: M Laitinen; Juha Hartikainen; Mikko O Hiltunen; Jaakko Eränen; M Kiviniemi; Outi Närvänen; Kimmo Mäkinen; Hannu Manninen; Mikko Syvänne; John F Martin; Markku Laakso; Seppo Ylä-Herttuala
Catheter-mediated vascular endothelial growth factor gene transfer to human coronary arteries after angioplasty.
Human gene therapy 2000;11(2):263-70.
2000: Seppo Ylä-Herttuala; J F Martin
Cardiovascular gene therapy.
Lancet 2000;355(9199):213-22.
2000: Therese Visted; J Thorsen; Frits Thorsen; Tracy-Ann Read; Elling Ulvestad; Olav Engebraaten; Dag R Sorensen; Seppo Ylä-Herttuala; K Tyynela; G Rucklidge; K Edvardsen; Rolf Bjerkvig; Morten Lund-Johansen
lacZ-neoR transfected glioma cells in syngeneic rats: growth pattern and characterization of the host immune response against cells transplanted inside and outside the CNS.
International journal of cancer. Journal international du cancer 2000;85(2):228-35.
2000: Kimmo Mäkinen; Sami Loimas; Veli-Matti Kosma; Jarmo Wahlfors; Seppo Ylä-Herttuala; Esko Alhava; Juhani Jänne
Adenovirus-mediated gene transfer into an experimental pancreatic tumour.
Annales chirurgiae et gynaecologiae 2000;89(2):99-103.
2000: Anu-Maaria Sandmair; Matti Vapalahti; Seppo Ylä-Herttuala
Adenovirus-mediated herpes simplex thymidine kinase gene therapy for brain tumors.
Advances in experimental medicine and biology 2000;465():163-70.
2000: Timo Pakkanen; M Laitinen; Maritta Hippeläinen; Mikko O Hiltunen; Esko Alhava; Seppo Ylä-Herttuala
Periadventitial lacZ gene transfer to pig carotid arteries using a biodegradable collagen collar or a wrap of collagen sheet with adenoviruses and plasmid-liposome complexes.
The journal of gene medicine 2000;2(1):52-60.
2000: Mikko O Hiltunen; Mikko Turunen; M Laitinen; Seppo Ylä-Herttuala
Insights into the molecular pathogenesis of atherosclerosis and therapeutic strategies using gene transfer.
Vascular medicine (London, England) 2000;5(1):41-8.
2000: Arja T Erkkilä; Outi Närvänen; Seppo Lehto; M I J Uusitupa; Seppo Ylä-Herttuala
Autoantibodies against oxidized low-density lipoprotein and cardiolipin in patients with coronary heart disease.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(1):204-9.
2000: Pauliina Lehtolainen; M Takeya; Seppo Ylä-Herttuala
Retrovirus-mediated, stable scavenger-receptor gene transfer leads to functional endocytotic receptor expression, foam cell formation, and increased susceptibility to apoptosis in rabbit aortic smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(1):52-60.
1999: Mikko O Hiltunen; M Niemi; Seppo Ylä-Herttuala
Functional genomics and DNA array techniques in atherosclerosis research.
Current opinion in lipidology 1999;10(6):515-9.
1999: Tomi P Häkkinen; Jukka S Luoma; Mikko O Hiltunen; Colin H Macphee; Kevin J Milliner; Lisa Patel; SQ Rice; David Tew; Kari Karkola; Seppo Ylä-Herttuala
Lipoprotein-associated phospholipase A(2), platelet-activating factor acetylhydrolase, is expressed by macrophages in human and rabbit atherosclerotic lesions.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(12):2909-17.
1999: Juhana M Hakumäki; harish poptani; Anu-Maaria Sandmair; Seppo Ylä-Herttuala; Risto A Kauppinen
1H MRS detects polyunsaturated fatty acid accumulation during gene therapy of glioma: implications for the in vivo detection of apoptosis.
Nature medicine 1999;5(11):1323-7.
1999: Timo Pakkanen; M Laitinen; Maritta Hippeläinen; Mikko O Hiltunen; Pauliina Lehtolainen; Pia Leppänen; Jukka S Luoma; Esko Alhava; Seppo Ylä-Herttuala
Improved gene transfer efficiency in liver with vesicular stomatitis virus G-protein pseudotyped retrovirus after partial liver resection and thymidine kinase-ganciclovir pre-treatment.
Pharmacological research : the official journal of the Italian Pharmacological Society 1999;40(5):451-7.
1999: Sari Mäkimattila; J S Luoma; Seppo Ylä-Herttuala; Robert Bergholm; Tapio Utriainen; Antti Virkamäki; M Mäntysaari; Paula Summanen; Hannele Yki-Järvinen
Autoantibodies against oxidized LDL and endothelium-dependent vasodilation in insulin-dependent diabetes mellitus.
Atherosclerosis 1999;147(1):115-22.
1999: Timo Pakkanen; Seppo Ylä-Herttuala
Gene therapy for atherosclerosis and atherosclerosis-related diseases.
Current atherosclerosis reports 1999;1(2):123-30.
1999: Mikko O Laukkanen; S Mannermaa; Mikko O Hiltunen; S Aittomäki; Kari J Airenne; Juhani Jänne; Seppo Ylä-Herttuala
Local hypomethylation in atherosclerosis found in rabbit ec-sod gene.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(9):2171-8.
1999: Jukka S Luoma; Seppo Ylä-Herttuala
Expression of inducible nitric oxide synthase in macrophages and smooth muscle cells in various types of human atherosclerotic lesions.
Virchows Archiv : an international journal of pathology 1999;434(6):561-8.
1999: Marika Ruponen; Seppo Ylä-Herttuala; Arto Urtti
Interactions of polymeric and liposomal gene delivery systems with extracellular glycosaminoglycans: physicochemical and transfection studies.
Biochimica et biophysica acta 1999;1415(2):331-41.
1999: Mikko O Hiltunen; M P Turunen; Seppo Ylä-Herttuala
Gene delivery to rabbit arteries using the collar model.
Methods in molecular medicine 1999;30():395-400.
1999: Helena Viita; Chandan K Sen; Sashwati Roy; T Siljamäki; T Nikkari; Seppo Ylä-Herttuala
High expression of human 15-lipoxygenase induces NF-kappaB-mediated expression of vascular cell adhesion molecule 1, intercellular adhesion molecule 1, and T-cell adhesion on human endothelial cells.
Antioxidants & redox signaling 1999;1(1):83-96.
1999: Anu-Maaria Sandmair; Sami Loimas; harish poptani; Pauli Vainio; Ritva Vanninen; Mikko P Turunen; Kristiina Tyynelä; Matti Vapalahti; Seppo Ylä-Herttuala
Low efficacy of gene therapy for rat BT4C malignant glioma using intra-tumoural transduction with thymidine kinase retrovirus packaging cell injections and ganciclovir treatment.
Acta neurochirurgica 1999;141(8):867-72; discussion 872-3.
1999: Helena Viita; Outi Närvänen; Seppo Ylä-Herttuala
Different apolipoprotein B breakdown patterns in models of oxidized low density lipoprotein.
Life sciences 1999;65(8):783-93.
1999: Ritva Ylitalo; Olli Jaakkola; P Lehtolainen; Seppo Ylä-Herttuala
Metabolism of modified LDL and foam cell formation in murine macrophage-like RAW 264 cells.
Life sciences 1999;64(21):1955-65.
1999: RS Agrawal; K Karhu; Jari A Laukkanen; P Kirkinen; Seppo Ylä-Herttuala; Y P Agrawal
Complement and anti-alpha-galactosyl natural antibody-mediated inactivation of murine retrovirus occurs in adult serum but not in umbilical cord serum.
Gene therapy 1999;6(1):146-8.
1999: Timo Pakkanen; M Laitinen; Maritta Hippeläinen; Hanna Kankkonen; Pauliina Lehtolainen; Pia Leppänen; Jukka S Luoma; R Tarvainen; Esko Alhava; Seppo Ylä-Herttuala
Enhanced plasma cholesterol lowering effect of retrovirus-mediated LDL receptor gene transfer to WHHL rabbit liver after improved surgical technique and stimulation of hepatocyte proliferation by combined partial liver resection and thymidine kinase--ganciclovir treatment.
Gene therapy 1999;6(1):34-41.
1999: Mikko Turunen; Mikko O Hiltunen; Marika Ruponen; L Virkamäki; Francis Szoka, jr; Arto Urtti; Seppo Ylä-Herttuala
Efficient adventitial gene delivery to rabbit carotid artery with cationic polymer-plasmid complexes.
Gene therapy 1999;6(1):6-11.
1999: Terho Lehtimäki; Saara Lehtinen; Tiina Solakivi; Matti Nikkilä; Olli Jaakkola; Hannu Jokela; Seppo Ylä-Herttuala; Jukka S Luoma; Timo Koivula; Tapio Nikkari
Autoantibodies against oxidized low density lipoprotein in patients with angiographically verified coronary artery disease.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(1):23-7.
1998: M Laitinen; Seppo Ylä-Herttuala
Vascular gene transfer for the treatment of restenosis and atherosclerosis.
Current opinion in lipidology 1998;9(5):465-9.
1998: Juhana M Hakumäki; harish poptani; AM Puumalainen; Sami Loimas; Leo Paljärvi; Seppo Ylä-Herttuala; Risto A Kauppinen
Quantitative 1H nuclear magnetic resonance diffusion spectroscopy of BT4C rat glioma during thymidine kinase-mediated gene therapy in vivo: identification of apoptotic response.
Cancer research 1998;58(17):3791-9.
1998: AM Puumalainen; Matti Vapalahti; RS Agrawal; Maija Kossila; Jari A Laukkanen; Pauliina Lehtolainen; Helena Viita; Leo Paljärvi; Ritva Vanninen; Seppo Ylä-Herttuala
Beta-galactosidase gene transfer to human malignant glioma in vivo using replication-deficient retroviruses and adenoviruses.
Human gene therapy 1998;9(12):1769-74.
1998: Seppo Ylä-Herttuala
Is oxidized low-density lipoprotein present in vivo?
Current opinion in lipidology 1998;9(4):337-44.
1998: Hannu Manninen; Ritva Vanninen; M Laitinen; Heikki T Räsänen; Pauli Vainio; Jukka S Luoma; Timo Pakkanen; Harri Tulla; Seppo Ylä-Herttuala
Intravascular ultrasound and magnetic resonance imaging in the assessment of atherosclerotic lesions in rabbit aorta. Correlation to histopathologic findings.
Investigative radiology 1998;33(8):464-71.
1998: M Laitinen; Kimmo Mäkinen; Hannu Manninen; Pekka J Matsi; Maija Kossila; RS Agrawal; Timo Pakkanen; Jukka S Luoma; Helena Viita; Juha Hartikainen; Esko Alhava; Markku Laakso; Seppo Ylä-Herttuala
Adenovirus-mediated gene transfer to lower limb artery of patients with chronic critical leg ischemia.
Human gene therapy 1998;9(10):1481-6.
1998: Markku Ahotupa; Jukka Marniemi; Terho Lehtimäki; Kati Talvinen; Olli T Raitakari; Tommi Vasankari; J Viikari; Jukka S Luoma; Seppo Ylä-Herttuala
Baseline diene conjugation in LDL lipids as a direct measure of in vivo LDL oxidation.
Clinical biochemistry 1998;31(4):257-61.
1998: Tomi P Häkkinen; Seppo Ylä-Herttuala
Artifact occurring during combined in situ hybridization and immunocytochemistry analysis because of positive chemography.
BioTechniques 1998;24(5):730-2.
1998: M Laitinen; Seppo Ylä-Herttuala
Adventitial gene transfer to arterial wall.
Pharmacological research : the official journal of the Italian Pharmacological Society 1998;37(4):251-4.
1998: TP Hiltunen; Jukka S Luoma; Tapio Nikkari; Seppo Ylä-Herttuala
Expression of LDL receptor, VLDL receptor, LDL receptor-related protein, and scavenger receptor in rabbit atherosclerotic lesions: marked induction of scavenger receptor and VLDL receptor expression during lesion development.
Circulation 1998;97(11):1079-86.
1998: harish poptani; AM Puumalainen; Olli H J Gröhn; Sami Loimas; R Kainulainen; Seppo Ylä-Herttuala; Risto A Kauppinen
Monitoring thymidine kinase and ganciclovir-induced changes in rat malignant glioma in vivo by nuclear magnetic resonance imaging.
Cancer gene therapy 1998;5(2):101-9.
1998: Jukka S Luoma; Pontus Strålin; Stefan L Marklund; TP Hiltunen; Terttu Särkioja; Seppo Ylä-Herttuala
Expression of extracellular SOD and iNOS in macrophages and smooth muscle cells in human and rabbit atherosclerotic lesions: colocalization with epitopes characteristic of oxidized LDL and peroxynitrite-modified proteins.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(2):157-67.
1998: AM Puumalainen; Matti Vapalahti; Seppo Ylä-Herttuala
Gene therapy for malignant glioma patients.
Advances in experimental medicine and biology 1998;451():505-9.
1998: Pia Leppänen; Jukka S Luoma; M H Hofker; L M Havekes; Seppo Ylä-Herttuala
Characterization of atherosclerotic lesions in apo E3-leiden transgenic mice.
Atherosclerosis 1998;136(1):147-52.
1998: Ritva Ylitalo; J Mönkkönen; Seppo Ylä-Herttuala
Effects of liposome-encapsulated bisphosphonates on acetylated LDL metabolism, lipid accumulation and viability of phagocyting cells.
Life sciences 1998;62(5):413-22.
1997: M Laitinen; Ian Zachary; Georg Breier; Timo Pakkanen; Tomi P Häkkinen; Jukka S Luoma; H Abedi; Werner Risau; M Soma; Markku Laakso; John F Martin; Seppo Ylä-Herttuala
VEGF gene transfer reduces intimal thickening via increased production of nitric oxide in carotid arteries.
Human gene therapy 1997;8(15):1737-44.
1997: M Laitinen; Timo Pakkanen; Elena Donetti; Roberta Baetta; Jukka S Luoma; Pauliina Lehtolainen; Helena Viita; R Agrawal; Atsushi Miyanohara; Theodore Friedmann; Werner Risau; John F Martin; M Soma; Seppo Ylä-Herttuala
Gene transfer into the carotid artery using an adventitial collar: comparison of the effectiveness of the plasmid-liposome complexes, retroviruses, pseudotyped retroviruses, and adenoviruses.
Human gene therapy 1997;8(14):1645-50.
1997: Olli T Raitakari; Otto Pitkänen; Terho Lehtimäki; Sanni Lahdenperä; H Iida; Seppo Ylä-Herttuala; Jukka S Luoma; K Mattila; T Nikkari; Marja-Riitta Taskinen; Jorma S A Viikari; Juhani Knuuti
In vivo low density lipoprotein oxidation relates to coronary reactivity in young men.
Journal of the American College of Cardiology 1997;30(1):97-102.
1997: Frits Thorsen; Therese Visted; P Lehtolainen; Seppo Ylä-Herttuala; Rolf Bjerkvig
Release of replication-deficient retroviruses from a packaging cell line: interaction with glioma tumor spheroids in vitro.
International journal of cancer. Journal international du cancer 1997;71(5):874-80.
1997: Seppo Ylä-Herttuala
Vascular gene transfer.
Current opinion in lipidology 1997;8(2):72-6.
1996: Seppo Ylä-Herttuala
Expression of lipoprotein receptors and related molecules in atherosclerotic lesions.
Current opinion in lipidology 1996;7(5):292-7.
1996: Seppo Ylä-Herttuala; Jukka S Luoma; Hanna Kankkonen; M Laukkanen; Pauliina Lehtolainen; Helena Viita
Pathogenesis of atherosclerosis.
Maturitas 1996;23 Suppl():S47-9.
1995: TP Hiltunen; Jukka S Luoma; Tapio Nikkari; Seppo Ylä-Herttuala
Induction of 15-lipoxygenase mRNA and protein in early atherosclerotic lesions.
Circulation 1995;92(11):3297-303.
1995: Seppo Ylä-Herttuala; Jukka S Luoma; Helena Viita; TP Hiltunen; Tero Sisto; Tapio Nikkari
Transfer of 15-lipoxygenase gene into rabbit iliac arteries results in the appearance of oxidation-specific lipid-protein adducts characteristic of oxidized low density lipoprotein.
The Journal of clinical investigation 1995;95(6):2692-8.
1995: G T Stavri; Ying Hong; Ian Zachary; G Breier; P A Baskerville; Seppo Ylä-Herttuala; W Risau; John F Martin; Jorge D Erusalimsky
Hypoxia and platelet-derived growth factor-BB synergistically upregulate the expression of vascular endothelial growth factor in vascular smooth muscle cells.
FEBS letters 1995;358(3):311-5.
1995: Tapio Nikkari; U Malo-Ranta; TP Hiltunen; Olli Jaakkola; Seppo Ylä-Herttuala
Monitoring of lipoprotein oxidation by gas chromatographic analysis of hydroxy fatty acids.
Journal of lipid research 1995;36(1):200-7.
1994: TP Hiltunen; M Raja-Honkala; Tapio Nikkari; Seppo Ylä-Herttuala
A PCR artifact under low-stringency conditions due to amplification by only one primer.
BioTechniques 1994;17(2):240-2.
1994: Ritva Ylitalo; O Oksala; Seppo Ylä-Herttuala; Pauli Ylitalo
Effects of clodronate (dichloromethylene bisphosphonate) on the development of experimental atherosclerosis in rabbits.
The Journal of laboratory and clinical medicine 1994;123(5):769-76.
1994: Jukka S Luoma; TP Hiltunen; Terttu Särkioja; S K Moestrup; J Gliemann; T Kodama; Tapio Nikkari; Seppo Ylä-Herttuala
Expression of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein and scavenger receptor in human atherosclerotic lesions.
The Journal of clinical investigation 1994;93(5):2014-21.
1994: U Malo-Ranta; Seppo Ylä-Herttuala; Timo Metsä-Ketelä; Olli Jaakkola; Eeva Moilanen; P Vuorinen; Tapio Nikkari
Nitric oxide donor GEA 3162 inhibits endothelial cell-mediated oxidation of low density lipoprotein.
FEBS letters 1994;337(2):179-83.
1990: Tero Sisto; Seppo Ylä-Herttuala; Jukka S Luoma; H Riekkinen; Tapio Nikkari
Biochemical composition of human internal mammary artery and saphenous vein.
Journal of vascular surgery 1990;11(3):418-22.
1989: Olli Jaakkola; Seppo Ylä-Herttuala; Terttu Särkioja; Tapio Nikkari
Macrophage foam cells from human aortic fatty streaks take up beta-VLDL and acetylated LDL in primary culture.
Atherosclerosis 1989;79(2-3):173-82.
1989: Olli Jaakkola; Tiina Solakivi; Seppo Ylä-Herttuala; Tapio Nikkari
Receptor-mediated binding and degradation of subfractions of human plasma low-density lipoprotein by cultured fibroblasts.
Biochimica et biophysica acta 1989;1005(2):118-22.
1989: Seppo Ylä-Herttuala; Jukka S Luoma; Tapio Nikkari; T Kivimäki
Down's syndrome and atherosclerosis.
Atherosclerosis 1989;76(2-3):269-72.
1988: Seppo Ylä-Herttuala; Erkki Pesonen; E Kaprio; J Rapola; T Soveri; J Viikari; E Savilahti; H Oksanen; Tapio Nikkari
Effect of repeated endotoxin treatment and hypercholesterolemia on preatherosclerotic lesions in weaned pigs. Part II. Lipid and glycosaminoglycan analysis of intima and inner media.
Atherosclerosis 1988;72(2-3):173-81.
1988: Seppo Ylä-Herttuala; Olli Jaakkola; C Ehnholm; M J Tikkanen; Tiina Solakivi; Terttu Särkioja; Tapio Nikkari
Characterization of two lipoproteins containing apolipoproteins B and E from lesion-free human aortic intima.
Journal of lipid research 1988;29(5):563-72.
1987: Erkki Pesonen; E Kaprio; J Rapola; T Soveri; J Viikari; E Savilahti; Seppo Ylä-Herttuala; H Oksanen
Effect of repeated endotoxin treatment and hypercholesterolemia on preatherosclerotic lesions in weaned pigs. Part 1. Scanning and transmission electron microscopic study.
Atherosclerosis 1987;65(1-2):89-98.
1986: Seppo Ylä-Herttuala; Olli Jaakkola; Tiina Solakivi; Helena Kuivaniemi; Tapio Nikkari
The effect of proteoglycans, collagen and lysyl oxidase on the metabolism of low density lipoprotein by macrophages.
Atherosclerosis 1986;62(1):73-80.