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Seppo Ylä-Herttuala

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Gene Therapy

Chemicals & Drugs

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Gene Transfer Techniques

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TOP 3
Ylä-Herttuala Seppo
Gene therapy with vascular endothelial growth factors.
Määttä Ann-Marie; Samaranayake Haritha; Pikkarainen Jere; Wirth Thomas; Ylä-Herttuala Seppo
Adenovirus mediated herpes simplex virus-thymidine kinase/ganciclovir gene therapy for resectable malignant glioma.
Wirth Thomas; Samaranayake Haritha; Pikkarainen Jere; Määttä Ann-Marie; Ylä-Herttuala Seppo
Clinical trials for glioblastoma multiforme using adenoviral vectors.

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All Publications

2009: Ylä-Herttuala Seppo
Gene therapy with vascular endothelial growth factors.
Biochemical Society transactions 2009;37(Pt 6):1198-200.
2009: Määttä Ann-Marie; Samaranayake Haritha; Pikkarainen Jere; Wirth Thomas; Ylä-Herttuala Seppo
Adenovirus mediated herpes simplex virus-thymidine kinase/ganciclovir gene therapy for resectable malignant glioma.
Current gene therapy 2009;9(5):356-67.
2009: Wirth Thomas; Samaranayake Haritha; Pikkarainen Jere; Määttä Ann-Marie; Ylä-Herttuala Seppo
Clinical trials for glioblastoma multiforme using adenoviral vectors.
Current opinion in molecular therapeutics 2009;11(5):485-92.
2009: Kanninen Katja; Heikkinen Riikka; Malm Tarja; Rolova Taisia; Kuhmonen Susanna; Leinonen Hanna; Ylä-Herttuala Seppo; Tanila Heikki; Levonen Anna-Liisa; Koistinaho Milla; Koistinaho Jari
Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(38):16505-10.
2009: Turunen Mikko P; Lehtola Tiia; Heinonen Suvi E; Assefa Genet S; Korpisalo Petra; Girnary Roseanne; Glass Christopher K; Väisänen Sami; Ylä-Herttuala Seppo
Efficient regulation of VEGF expression by promoter-targeted lentiviral shRNAs based on epigenetic mechanism: a novel example of epigenetherapy.
Circulation research 2009;105(6):604-9.
2009: Lahtinen L; Huusko N; Myöhänen H; Lehtivarjo A-K; Pellinen R; Turunen M P; Ylä-Herttuala S; Pirinen E; Pitkänen A
Expression of urokinase-type plasminogen activator receptor is increased during epileptogenesis in the rat hippocampus.
Neuroscience 2009;163(1):316-28.
2009: Turunen Mikko P; Aavik Einari; Ylä-Herttuala Seppo
Epigenetics and atherosclerosis.
Biochimica et biophysica acta 2009;1790(9):886-91.
2009: Lesch Hanna P; Pikkarainen Jere T; Kaikkonen Minna U; Taavitsainen Miia; Samaranayake Haritha; Lehtolainen-Dalkilic Pauliina; Vuorio Taina; Määttä Ann-Marie; Wirth Thomas; Airenne Kari J; Ylä-Herttuala Seppo
Avidin fusion protein-expressing lentiviral vector for targeted drug delivery.
Human gene therapy 2009;20(8):871-82.
2009: Kinnunen K; Puustjärvi T; Teräsvirta M; Nurmenniemi P; Heikura T; Laidinen S; Paavonen T; Uusitalo H; Ylä-Herttuala S
Differences in retinal neovascular tissue and vitreous humour in patients with type 1 and type 2 diabetes.
The British journal of ophthalmology 2009;93(8):1109-15.
2009: Laitinen Iina; Saraste Antti; Weidl Eliane; Poethko Thorsten; Weber Axel W; Nekolla Stephan G; Leppänen Pia; Ylä-Herttuala Seppo; Hölzlwimmer Gabriele; Walch Axel; Esposito Irene; Wester Hans-Jürgen; Knuuti Juhani; Schwaiger Markus
Evaluation of alphavbeta3 integrin-targeted positron emission tomography tracer 18F-galacto-RGD for imaging of vascular inflammation in atherosclerotic mice.
Circulation. Cardiovascular imaging 2009;2(4):331-8.
2009: Kaikkonen M U; Lesch H P; Pikkarainen J; Räty J K; Vuorio T; Huhtala T; Taavitsainen M; Laitinen T; Tuunanen P; Gröhn O; Närvänen A; Airenne K J; Ylä-Herttuala S
(Strept)avidin-displaying lentiviruses as versatile tools for targeting and dual imaging of gene delivery.
Gene therapy 2009;16(7):894-904.
2009: Anisimov Andrey; Alitalo Annamari; Korpisalo Petra; Soronen Jarkko; Kaijalainen Seppo; Leppänen Veli-Matti; Jeltsch Michael; Ylä-Herttuala Seppo; Alitalo Kari
Activated forms of VEGF-C and VEGF-D provide improved vascular function in skeletal muscle.
Circulation research 2009;104(11):1302-12.
2009: Toivanen Pyry I; Nieminen Tiina; Viitanen Lenita; Alitalo Annamari; Roschier Miia; Jauhiainen Suvi; Markkanen Johanna E; Laitinen Olli H; Airenne Tomi T; Salminen Tiina A; Johnson Mark S; Airenne Kari J; Ylä-Herttuala Seppo
Novel vascular endothelial growth factor D variants with increased biological activity.
The Journal of biological chemistry 2009;284(23):16037-48.
2009: Norrmén Camilla; Ivanov Konstantin I; Cheng Jianpin; Zangger Nadine; Delorenzi Mauro; Jaquet Muriel; Miura Naoyuki; Puolakkainen Pauli; Horsley Valerie; Hu Junhao; Augustin Hellmut G; Ylä-Herttuala Seppo; Alitalo Kari; Petrova Tatiana V
FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1.
The Journal of cell biology 2009;185(3):439-57.
2009: Kinnunen Kati; Kalesnykas Giedrius; Mähönen Anssi J; Laidinen Svetlana; Holma Liisa; Heikura Tommi; Airenne Kari; Uusitalo Hannu; Ylä-Herttuala Seppo
Baculovirus is an efficient vector for the transduction of the eye: comparison of baculovirus- and adenovirus-mediated intravitreal vascular endothelial growth factor D gene transfer in the rabbit eye.
The journal of gene medicine 2009;11(5):382-9.
2009: Hedman M; Muona K; Hedman A; Kivelä A; Syvänne M; Eränen J; Rantala A; Stjernvall J; Nieminen M S; Hartikainen J; Ylä-Herttuala S
Eight-year safety follow-up of coronary artery disease patients after local intracoronary VEGF gene transfer.
Gene therapy 2009;16(5):629-34.
2009: Karvinen H; Rutanen J; Leppänen O; Lach R; Levonen A-L; Eriksson U; Ylä-Herttuala S
PDGF-C and -D and their receptors PDGFR-alpha and PDGFR-beta in atherosclerotic human arteries.
European journal of clinical investigation 2009;39(4):320-7.
2009: Kärkkäinen Anna-Mari; Kotimaa Antti; Huusko Jenni; Kholova Ivana; Heinonen Suvi Elina; Stefanska Anna; Dijkstra Marike Hinke; Purhonen Hanna; Hämäläinen Eveliina; Mäkinen Petri Ilmari; Turunen Mikko Petri; Ylä-Herttuala Seppo
Vascular endothelial growth factor-D transgenic mice show enhanced blood capillary density, improved postischemic muscle regeneration, and increased susceptibility to tumor formation.
Blood 2009;113(18):4468-75.
2009: Lähteenvuo Johanna E; Lähteenvuo Markku T; Kivelä Antti; Rosenlew Carolina; Falkevall Annelie; Klar Joakim; Heikura Tommi; Rissanen Tuomas T; Vähäkangas Elisa; Korpisalo Petra; Enholm Berndt; Carmeliet Peter; Alitalo Kari; Eriksson Ulf; Ylä-Herttuala Seppo
Vascular endothelial growth factor-B induces myocardium-specific angiogenesis and arteriogenesis via vascular endothelial growth factor receptor-1- and neuropilin receptor-1-dependent mechanisms.
Circulation 2009;119(6):845-56.
2009: Kangasniemi L; Koskinen M; Jokinen M; Toriseva M; Ala-Aho R; Kähäri V-M; Jalonen H; Ylä-Herttuala S; Moilanen H; Stenman U-H; Diaconu I; Kanerva A; Pesonen S; Hakkarainen T; Hemminki A
Extended release of adenovirus from silica implants in vitro and in vivo.
Gene therapy 2009;16(1):103-10.
2009: Laitinen Iina; Marjamäki Päivi; Någren Kjell; Laine V Jukka O; Wilson Ian; Leppänen Pia; Ylä-Herttuala Seppo; Roivainen Anne; Knuuti Juhani
Uptake of inflammatory cell marker [11C]PK11195 into mouse atherosclerotic plaques.
European journal of nuclear medicine and molecular imaging 2009;36(1):73-80.
2009: Kärkkäinen Hanna-Riikka; Lesch Hanna P; Määttä Antti I; Toivanen Pyry I; Mähönen Anssi J; Roschier Miia M; Airenne Kari J; Laitinen Olli H; Ylä-Herttuala Seppo
A 96-well format for a high-throughput baculovirus generation, fast titering and recombinant protein production in insect and mammalian cells.
BMC research notes 2009;2():63.
2009: Laakkonen Johanna P; Mäkelä Anna R; Kakkonen Elina; Turkki Paula; Kukkonen Sari; Peränen Johan; Ylä-Herttuala Seppo; Airenne Kari J; Oker-Blom Christian; Vihinen-Ranta Maija; Marjomäki Varpu
Clathrin-independent entry of baculovirus triggers uptake of E. coli in non-phagocytic human cells.
PloS one 2009;4(4):e5093.
2008: Botusan Ileana Ruxandra; Sunkari Vivekananda Gupta; Savu Octavian; Catrina Anca Irinel; Grünler Jacob; Lindberg Stina; Pereira Teresa; Ylä-Herttuala Seppo; Poellinger Lorenz; Brismar Kerstin; Catrina Sergiu-Bogdan
Stabilization of HIF-1alpha is critical to improve wound healing in diabetic mice.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(49):19426-31.
2008: Korpisalo Petra; Karvinen Henna; Rissanen Tuomas T; Kilpijoki Johanna; Marjomäki Varpu; Baluk Peter; McDonald Donald M; Cao Yihai; Eriksson Ulf; Alitalo Kari; Ylä-Herttuala Seppo
Vascular endothelial growth factor-A and platelet-derived growth factor-B combination gene therapy prolongs angiogenic effects via recruitment of interstitial mononuclear cells and paracrine effects rather than improved pericyte coverage of angiogenic vessels.
Circulation research 2008;103(10):1092-9.
2008: Kanninen Katja; Malm Tarja M; Jyrkkänen Henna-Kaisa; Goldsteins Gundars; Keksa-Goldsteine Velta; Tanila Heikki; Yamamoto Masayuki; Ylä-Herttuala Seppo; Levonen Anna-Liisa; Koistinaho Jari
Nuclear factor erythroid 2-related factor 2 protects against beta amyloid.
Molecular and cellular neurosciences 2008;39(3):302-13.
2008: Korpisalo Petra; Rissanen Tuomas T; Bengtsson Timo; Liimatainen Timo; Laidinen Svetlana; Karvinen Henna; Markkanen Johanna E; Gröhn Olli H; Ylä-Herttuala Seppo
Therapeutic angiogenesis with placental growth factor improves exercise tolerance of ischaemic rabbit hindlimbs.
Cardiovascular research 2008;80(2):263-70.
2008: Karpanen Terhi; Bry Maija; Ollila Hanna M; Seppänen-Laakso Tuulikki; Liimatta Erkki; Leskinen Hanna; Kivelä Riikka; Helkamaa Teemu; Merentie Mari; Jeltsch Michael; Paavonen Karri; Andersson Leif C; Mervaala Eero; Hassinen Ilmo E; Ylä-Herttuala Seppo; Oresic Matej; Alitalo Kari
Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy.
Circulation research 2008;103(9):1018-26.
2008: Kirjavainen Anna; Sulg Marilin; Heyd Florian; Alitalo Kari; Ylä-Herttuala Seppo; Möröy Tarik; Petrova Tatiana V; Pirvola Ulla
Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia.
Developmental biology 2008;322(1):33-45.
2008: Laurema Anniina; Riekkinen Mervi; Heikura Tommi; Vähäkangas Elisa; Manninen Hannu; Heinonen Seppo; Ylä-Herttuala Seppo
The administration of an adenoviral thymidine kinase suicide gene to the uterine artery of rabbits does not affect fertility: a safety study of pregnant and nonpregnant rabbits and their offspring.
The journal of gene medicine 2008;10(9):1005-11.
2008: Lesch H P; Turpeinen S; Niskanen E A; Mähönen A J; Airenne K J; Ylä-Herttuala S
Generation of lentivirus vectors using recombinant baculoviruses.
Gene therapy 2008;15(18):1280-6.
2008: Hurttila H; Koponen J K; Kansanen E; Jyrkkänen H-K; Kivelä A; Kylätie R; Ylä-Herttuala S; Levonen A-L
Oxidative stress-inducible lentiviral vectors for gene therapy.
Gene therapy 2008;15(18):1271-9.
2008: Saraste Antti; Kytö Ville; Laitinen Iina; Saraste Markku; Leppänen Pia; Ylä-Herttuala Seppo; Saukko Pekka; Hartiala Jaakko; Knuuti Juhani
Severe coronary artery stenoses and reduced coronary flow velocity reserve in atherosclerotic mouse model: Doppler echocardiography validation study.
Atherosclerosis 2008;200(1):89-94.
2008: Tammela Tuomas; Zarkada Georgia; Wallgard Elisabet; Murtomäki Aino; Suchting Steven; Wirzenius Maria; Waltari Marika; Hellström Mats; Schomber Tibor; Peltonen Reetta; Freitas Catarina; Duarte Antonio; Isoniemi Helena; Laakkonen Pirjo; Christofori Gerhard; Ylä-Herttuala Seppo; Shibuya Masabumi; Pytowski Bronislaw; Eichmann Anne; Betsholtz Christer; Alitalo Kari
Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation.
Nature 2008;454(7204):656-60.
2008: Kivelä Annukka M; Kansanen Emilia; Jyrkkänen Henna-Kaisa; Nurmi Tarja; Ylä-Herttuala Seppo; Levonen Anna-Liisa
Enterolactone induces heme oxygenase-1 expression through nuclear factor-E2-related factor 2 activation in endothelial cells.
The Journal of nutrition 2008;138(7):1263-8.
2008: Pulkkinen Kati; Malm Tarja; Turunen Mikko; Koistinaho Jari; Ylä-Herttuala Seppo
Hypoxia induces microRNA miR-210 in vitro and in vivo ephrin-A3 and neuronal pentraxin 1 are potentially regulated by miR-210.
FEBS letters 2008;582(16):2397-401.
2008: Jyrkkänen Henna-Kaisa; Kansanen Emilia; Inkala Matias; Kivelä Annukka M; Hurttila Hanna; Heinonen Suvi E; Goldsteins Gundars; Jauhiainen Suvi; Tiainen Satu; Makkonen Harri; Oskolkova Olga; Afonyushkin Taras; Koistinaho Jari; Yamamoto Masayuki; Bochkov Valery N; Ylä-Herttuala Seppo; Levonen Anna-Liisa
Nrf2 regulates antioxidant gene expression evoked by oxidized phospholipids in endothelial cells and murine arteries in vivo.
Circulation research 2008;103(1):e1-9.
2008: Fledderus Joost O; Boon Reinier A; Volger Oscar L; Hurttila Hanna; Ylä-Herttuala Seppo; Pannekoek Hans; Levonen Anna-Liisa; Horrevoets Anton J G
KLF2 primes the antioxidant transcription factor Nrf2 for activation in endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(7):1339-46.
2008: Heckman Caroline A; Holopainen Tanja; Wirzenius Maria; Keskitalo Salla; Jeltsch Michael; Ylä-Herttuala Seppo; Wedge Stephen R; Jürgensmeier Juliane M; Alitalo Kari
The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis.
Cancer research 2008;68(12):4754-62.
2008: Bhardwaj Shalini; Roy Himadri; Ylä-Herttuala Seppo
Gene therapy to prevent occlusion of venous bypass grafts.
Expert review of cardiovascular therapy 2008;6(5):641-52.
2008: Sierra A; Michaeli S; Niskanen J-P; Valonen P K; Gröhn H I; Ylä-Herttuala S; Garwood M; Gröhn O H
Water spin dynamics during apoptotic cell death in glioma gene therapy probed by T1rho and T2rho.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2008;59(6):1311-9.
2008: Liimatainen Timo J; Erkkilä Arja T; Valonen Piia; Vidgren Helvi; Lakso Merja; Wong Garry; Gröhn Olli H J; Ylä-Herttuala Seppo; Hakumäki Juhana M
1H MR spectroscopic imaging of phospholipase-mediated membrane lipid release in apoptotic rat glioma in vivo.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2008;59(6):1232-8.
2008: Kaikkonen Minna U; Viholainen Jenni I; Närvänen Ale; Ylä-Herttuala Seppo; Airenne Kari J
Targeting and purification of metabolically biotinylated baculovirus.
Human gene therapy 2008;19(6):589-600.
2008: Odermarsky M; Andersson S; Pesonen E; Sjöblad S; Ylä-Herttuala S; Liuba P
Respiratory infection recurrence and passive smoking in early atherosclerosis in children and adolescents with type 1 diabetes.
European journal of clinical investigation 2008;38(6):381-8.
2008: Purhonen Susanna; Palm Jarmo; Rossi Derrick; Kaskenpää Nina; Rajantie Iiro; Ylä-Herttuala Seppo; Alitalo Kari; Weissman Irving L; Salven Petri
Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(18):6620-5.
2008: Levonen Anna-Liisa; Vähäkangas Elisa; Koponen Jonna K; Ylä-Herttuala Seppo
Antioxidant gene therapy for cardiovascular disease: current status and future perspectives.
Circulation 2008;117(16):2142-50.
2008: Tuomisto Tiina T; Lumivuori Henri; Kansanen Emilia; Häkkinen Sanna-Kaisa; Turunen Mikko P; van Thienen Johannes V; Horrevoets Anton J; Levonen Anna-Liisa; Ylä-Herttuala Seppo
Simvastatin has an anti-inflammatory effect on macrophages via upregulation of an atheroprotective transcription factor, Kruppel-like factor 2.
Cardiovascular research 2008;78(1):175-84.
2008: Laakkonen Johanna P; Kaikkonen Minna U; Ronkainen Paula H A; Ihalainen Teemu O; Niskanen Einari A; Häkkinen Maija; Salminen Mirka; Kulomaa Markku S; Ylä-Herttuala Seppo; Airenne Kari J; Vihinen-Ranta Maija
Baculovirus-mediated immediate-early gene expression and nuclear reorganization in human cells.
Cellular microbiology 2008;10(3):667-81.
2008: Viita Helena; Markkanen Johanna; Eriksson Emmi; Nurminen Markku; Kinnunen Kati; Babu Mohan; Heikura Tommi; Turpeinen Sanna; Laidinen Svetlana; Takalo Teemu; Ylä-Herttuala Seppo
15-lipoxygenase-1 prevents vascular endothelial growth factor A- and placental growth factor-induced angiogenic effects in rabbit skeletal muscles via reduction in growth factor mRNA levels, NO bioactivity, and downregulation of VEGF receptor 2 expression.
Circulation research 2008;102(2):177-84.
2008: Rissanen Tuomas T; Korpisalo Petra; Karvinen Henna; Liimatainen Timo; Laidinen Svetlana; Gröhn Olli H; Ylä-Herttuala Seppo
High-resolution ultrasound perfusion imaging of therapeutic angiogenesis.
JACC. Cardiovascular imaging 2008;1(1):83-91.
2008: Räty Jani K; Lesch Hanna P; Wirth Thomas; Ylä-Herttuala Seppo
Improving safety of gene therapy.
Current drug safety 2008;3(1):46-53.
2007: Bräsen Jan Hinrich; Leppänen Olli; Inkala Matias; Heikura Tommi; Levin Max; Ahrens Fabian; Rutanen Juha; Pietsch Hubertus; Bergqvist David; Levonen Anna-Liisa; Basu Samar; Zeller Thomas; Klöppel Günter; Laukkanen Mikko O; Ylä-Herttuala Seppo
Extracellular superoxide dismutase accelerates endothelial recovery and inhibits in-stent restenosis in stented atherosclerotic Watanabe heritable hyperlipidemic rabbit aorta.
Journal of the American College of Cardiology 2007;50(23):2249-53.
2007: Ylä-Herttuala Seppo; Alitalo Kari
On the relationship of LDL and VEGFR1: not just a family affair.
EMBO reports 2007;8(12):1127-8.
2007: Tammela Tuomas; Saaristo Anne; Holopainen Tanja; Lyytikkä Johannes; Kotronen Anna; Pitkonen Miia; Abo-Ramadan Usama; Ylä-Herttuala Seppo; Petrova Tatiana V; Alitalo Kari
Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation.
Nature medicine 2007;13(12):1458-66.
2007: Sipola A; Ilvesaro J; Birr E; Jalovaara P; Pettersson R F; Stenbäck F; Ylä-Herttuala S; Hautala T; Tuukkanen J
Endostatin inhibits endochondral ossification.
The journal of gene medicine 2007;9(12):1057-64.
2007: Koponen Jonna K; Kekarainen Tuija; E Heinonen Suvi; Laitinen Anita; Nystedt Johanna; Laine Jarmo; Ylä-Herttuala Seppo
Umbilical cord blood-derived progenitor cells enhance muscle regeneration in mouse hindlimb ischemia model.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(12):2172-7.
2007: Heinonen Suvi E; Leppänen Pia; Kholová Ivana; Lumivuori Henri; Häkkinen Sanna-Kaisa; Bosch Fatima; Laakso Markku; Ylä-Herttuala Seppo
Increased atherosclerotic lesion calcification in a novel mouse model combining insulin resistance, hyperglycemia, and hypercholesterolemia.
Circulation research 2007;101(10):1058-67.
2007: Räty Jani Kristian; Liimatainen Timo; Unelma Kaikkonen Minna; Gröhn Olli; Airenne Kari Juhani; Ylä-Herttuala Seppo
Non-invasive Imaging in Gene Therapy.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(9):1579-86.
2007: Mähönen Anssi J; Airenne Kari J; Purola Sanna; Peltomaa Erik; Kaikkonen Minna U; Riekkinen Mervi S; Heikura Tommi; Kinnunen Kati; Roschier Miia M; Wirth Thomas; Ylä-Herttuala Seppo
Post-transcriptional regulatory element boosts baculovirus-mediated gene expression in vertebrate cells.
Journal of biotechnology 2007;131(1):1-8.
2007: Helppolainen Satu H; Nurminen Kirsi P; Määttä Juha A E; Halling Katrin K; Slotte J Peter; Huhtala Tuulia; Liimatainen Timo; Ylä-Herttuala Seppo; Airenne Kari J; Närvänen Ale; Jänis Janne; Vainiotalo Pirjo; Valjakka Jarkko; Kulomaa Markku S; Nordlund Henri R
Rhizavidin from Rhizobium etli: the first natural dimer in the avidin protein family.
The Biochemical journal 2007;405(3):397-405.
2007: Rissanen Tuomas T; Ylä-Herttuala Seppo
Current status of cardiovascular gene therapy.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(7):1233-47.
2007: Pirinen Eija; Kuulasmaa Teemu; Pietilä Marko; Heikkinen Sami; Tusa Maija; Itkonen Paula; Boman Susanna; Skommer Joanna; Virkamäki Antti; Hohtola Esa; Kettunen Mikko; Fatrai Szabolcs; Kansanen Emilia; Koota Suvi; Niiranen Kirsi; Parkkinen Jyrki; Levonen Anna-Liisa; Ylä-Herttuala Seppo; Hiltunen J Kalervo; Alhonen Leena; Smith Ulf; Jänne Juhani; Laakso Markku
Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism.
Molecular and cellular biology 2007;27(13):4953-67.
2007: Wirzenius Maria; Tammela Tuomas; Uutela Marko; He Yulong; Odorisio Teresa; Zambruno Giovanna; Nagy Janice A; Dvorak Harold F; Ylä-Herttuala Seppo; Shibuya Masabumi; Alitalo Kari
Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting.
The Journal of experimental medicine 2007;204(6):1431-40.
2007: Kettunen Mikko I; Sierra Alejandra; Närväinen M Johanna; Valonen Piia K; Ylä-Herttuala Seppo; Kauppinen Risto A; Gröhn Olli H J
Low spin-lock field T1 relaxation in the rotating frame as a sensitive MR imaging marker for gene therapy treatment response in rat glioma.
Radiology 2007;243(3):796-803.
2007: Räty J K; Liimatainen T; Huhtala T; Kaikkonen M U; Airenne K J; Hakumäki J M; Närvänen A; Ylä-Herttuala S
SPECT/CT imaging of baculovirus biodistribution in rat.
Gene therapy 2007;14(12):930-8.
2007: Tammela Tuomas; He Yulong; Lyytikkä Johannes; Jeltsch Michael; Markkanen Johanna; Pajusola Katri; Ylä-Herttuala Seppo; Alitalo Kari
Distinct architecture of lymphatic vessels induced by chimeric vascular endothelial growth factor-C/vascular endothelial growth factor heparin-binding domain fusion proteins.
Circulation research 2007;100(10):1468-75.
2007: Yan Daoguang; Lehto Markku; Rasilainen Laura; Metso Jari; Ehnholm Christian; Ylä-Herttuala Seppo; Jauhiainen Matti; Olkkonen Vesa M
Oxysterol binding protein induces upregulation of SREBP-1c and enhances hepatic lipogenesis.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(5):1108-14.
2007: Levonen Anna-Liisa; Inkala Matias; Heikura Tommi; Jauhiainen Suvi; Jyrkkänen Henna-Kaisa; Kansanen Emilia; Määttä Kirsi; Romppanen Elina; Turunen Päivi; Rutanen Juha; Ylä-Herttuala Seppo
Nrf2 gene transfer induces antioxidant enzymes and suppresses smooth muscle cell growth in vitro and reduces oxidative stress in rabbit aorta in vivo.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(4):741-7.
2007: Kholová Ivana; Koota Suvi; Kaskenpää Nina; Leppänen Pia; Närväinen Johanna; Kavec Martin; Rissanen Tuomas T; Hazes Thierry; Korpisalo Petra; Gröhn Olli; Ylä-Herttuala Seppo
Adenovirus-mediated gene transfer of human vascular endothelial growth factor-d induces transient angiogenic effects in mouse hind limb muscle.
Human gene therapy 2007;18(3):232-44.
2007: Ylä-Herttuala Seppo; Rissanen Tuomas T; Vajanto Ismo; Hartikainen Juha
Vascular endothelial growth factors: biology and current status of clinical applications in cardiovascular medicine.
Journal of the American College of Cardiology 2007;49(10):1015-26.
2007: Rautsi Outi; Lehmusvaara Saara; Salonen Tuula; Häkkinen Katja; Sillanpää Maarit; Hakkarainen Tanja; Heikkinen Sami; Vähäkangas Elisa; Ylä-Herttuala Seppo; Hinkkanen Ari; Julkunen Ilkka; Wahlfors Jarmo; Pellinen Riikka
Type I interferon response against viral and non-viral gene transfer in human tumor and primary cell lines.
The journal of gene medicine 2007;9(2):122-35.
2007: Laurema Anniina; Lumme Satu; Heinonen Suvi E; Heinonen Seppo; Ylä-Herttuala Seppo
Transduction patterns and efficiencies in rabbit uterine tissues after intraluminal uterine adenovirus administration vary with the reproductive cycle.
Acta obstetricia et gynecologica Scandinavica 2007;86(9):1035-40.
2007: Liuba Petru; Aburawi Elhadi H; Pesonen Erkki; Andersson Sture; Truedsson Lennart; Ylä-Herttuala Seppo; Holmberg Lars
Residual adverse changes in arterial endothelial function and LDL oxidation after a mild systemic inflammation induced by influenza vaccination.
Annals of medicine 2007;39(5):392-9.
2007: Rissanen Tuomas T; Ylä-Herttuala Seppo
[Not Available]
Duodecim; lääketieteellinen aikakauskirja 2007;123(3):306-16.
2007: Back Johan; Kankuri Esko; Ikonen Tuija; Pätilä Tommi; Sinisalo Juha; Laine Mika; Vapaatalo Heikki; Koponen Jonna; Hukkanen Mika; Ylä-Herttuala Seppo; Alitalo Riitta; Kupari Markku; Harjula Ari
[Not Available]
Duodecim; lääketieteellinen aikakauskirja 2007;123(4):398-405.
2006: Laitinen Iina; Marjamäki Päivi; Haaparanta Merja; Savisto Nina; Laine V Jukka O; Soini Sanna L; Wilson Ian; Leppänen Pia; Ylä-Herttuala Seppo; Roivainen Anne; Knuuti Juhani
Non-specific binding of [18F]FDG to calcifications in atherosclerotic plaques: experimental study of mouse and human arteries.
European journal of nuclear medicine and molecular imaging 2006;33(12):1461-7.
2006: Deiner Carolin; Schwimmbeck Peter Lothar; Koehler Ina Sabine; Loddenkemper Christoph; Noutsias Michel; Nikol Sigrid; Schultheiss Heinz-Peter; Ylä-Herttuala Seppo; Pels Klaus
Adventitial VEGF165 gene transfer prevents lumen loss through induction of positive arterial remodeling after PTCA in porcine coronary arteries.
Atherosclerosis 2006;189(1):123-32.
2006: Roy Himadri; Bhardwaj Shalini; Babu Mohan; Kokina Ilze; Uotila Sanna; Ahtialansaari Tiia; Laitinen Teemu; Hakumaki Juhana; Laakso Markku; Herzig Karl-Heinz; Ylä-Herttuala Seppo
VEGF-A, VEGF-D, VEGF receptor-1, VEGF receptor-2, NF-kappaB, and RAGE in atherosclerotic lesions of diabetic Watanabe heritable hyperlipidemic rabbits.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(12):2159-61.
2006: Räty J K; Liimatainen T; Wirth T; Airenne K J; Ihalainen T O; Huhtala T; Hamerlynck E; Vihinen-Ranta M; Närvänen A; Ylä-Herttuala S; Hakumäki J M
Magnetic resonance imaging of viral particle biodistribution in vivo.
Gene therapy 2006;13(20):1440-6.
2006: Wirth Thomas; Hedman Marja; Mäkinen Kimmo; Manninen Hannu; Immonen Arto; Vapalahti Matti; Ylä-Herttuala Seppo
Safety profile of plasmid/liposomes and virus vectors in clinical gene therapy.
Current drug safety 2006;1(3):253-7.
2006: Ylä-Herttuala Seppo
An update on angiogenic gene therapy: vascular endothelial growth factor and other directions.
Current opinion in molecular therapeutics 2006;8(4):295-300.
2006: Karpanen Terhi; Wirzenius Maria; Mäkinen Taija; Veikkola Tanja; Haisma Hidde J; Achen Marc G; Stacker Steven A; Pytowski Bronislaw; Ylä-Herttuala Seppo; Alitalo Kari
Lymphangiogenic growth factor responsiveness is modulated by postnatal lymphatic vessel maturation.
The American journal of pathology 2006;169(2):708-18.
2006: Kinnunen K; Korpisalo P; Rissanen T T; Heikura T; Viita H; Uusitalo H; Ylä-Herttuala S
Overexpression of VEGF-A induces neovascularization and increased vascular leakage in rabbit eye after intravitreal adenoviral gene transfer.
Acta physiologica (Oxford, England) 2006;187(4):447-57.
2006: Roy Himadri; Bhardwaj Shalini; Ylä-Herttuala Seppo
Biology of vascular endothelial growth factors.
FEBS letters 2006;580(12):2879-87.
2006: Nälsén Cecilia; Vessby Bengt; Berglund Lars; Uusitupa Matti; Hermansen Kjeld; Riccardi Gabrielle; Rivellese Angela; Storlien Len; Erkkilä Arja; Ylä-Herttuala Seppo; Tapsell Linda; Basu Samar
Dietary (n-3) fatty acids reduce plasma F2-isoprostanes but not prostaglandin F2alpha in healthy humans.
The Journal of nutrition 2006;136(5):1222-8.
2006: Turunen Päivi; Puhakka Hanna L; Heikura Tommi; Romppanen Elina; Inkala Matias; Leppänen Olli; Ylä-Herttuala Seppo
Extracellular superoxide dismutase with vaccinia virus anti-inflammatory protein 35K or tissue inhibitor of metalloproteinase-1: Combination gene therapy in the treatment of vein graft stenosis in rabbits.
Human gene therapy 2006;17(4):405-14.
2006: Mäntylä Tuomas; Hakumäki Juhana M; Huhtala Tuulia; Närvänen Ale; Ylä-Herttuala Seppo
Targeted magnetic resonance imaging of Scavidin-receptor in human umbilical vein endothelial cells in vitro.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2006;55(4):800-4.
2006: Mäkinen Petri I; Koponen Jonna K; Kärkkäinen Anna-Mari; Malm Tarja M; Pulkkinen Kati H; Koistinaho Jari; Turunen Mikko P; Ylä-Herttuala Seppo
Stable RNA interference: comparison of U6 and H1 promoters in endothelial cells and in mouse brain.
The journal of gene medicine 2006;8(4):433-41.
2006: Pätilä Tommi; Ikonen Tuija; Rutanen Juha; Ahonen Aapo; Lommi Jyri; Lappalainen Kimmo; Krogerus Leena; Ihlberg Leo; Partanen Taina A; Lähteenoja Liisa; Virtanen Kari; Alitalo Kari; Ylä-Herttuala Seppo; Harjula Ari
Vascular endothelial growth factor C-induced collateral formation in a model of myocardial ischemia.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2006;25(2):206-13.
2006: Kaikkonen M U; Räty J K; Airenne K J; Wirth T; Heikura T; Ylä-Herttuala S
Truncated vesicular stomatitis virus G protein improves baculovirus transduction efficiency in vitro and in vivo.
Gene therapy 2006;13(4):304-12.
2006: Leppänen Pia; Kholová Ivana; Mähönen Anssi J; Airenne Kari; Koota Suvi; Mansukoski Hannu; Närväinen Johanna; Wirzenius Maria; Alhonen Leena; Jänne Juhani; Alitalo Kari; Ylä-Herttuala Seppo
Short and long-term effects of hVEGF-A(165) in Cre-activated transgenic mice.
PloS one 2006;1():e13.
2005: Roy Himadri; Bhardwaj Shalini; Babu Mohan; Jauhiainen Suvi; Herzig Karl-Heinz; Bellu Anna R; Haisma Hidde J; Carmeliet Peter; Alitalo Kari; Ylä-Herttuala Seppo
Adenovirus-mediated gene transfer of placental growth factor to perivascular tissue induces angiogenesis via upregulation of the expression of endogenous vascular endothelial growth factor-A.
Human gene therapy 2005;16(12):1422-8.
2005: Rissanen Tuomas T; Korpisalo Petra; Markkanen Johanna E; Liimatainen Timo; Ordén Maija-Riitta; Kholová Ivana; de Goede Anna; Heikura Tommi; Gröhn Olli H; Ylä-Herttuala Seppo
Blood flow remodels growing vasculature during vascular endothelial growth factor gene therapy and determines between capillary arterialization and sprouting angiogenesis.
Circulation 2005;112(25):3937-46.
2005: Luoma Jukka S; Kareinen Anu; Närvänen Outi; Viitanen Laura; Laakso Markku; Ylä-Herttuala Seppo
Autoantibodies against oxidized LDL are associated with severe chest pain attacks in patients with coronary heart disease.
Free radical biology & medicine 2005;39(12):1660-5.
2005: Bhardwaj S; Roy H; Heikura T; Ylä-Herttuala S
VEGF-A, VEGF-D and VEGF-D(DeltaNDeltaC) induced intimal hyperplasia in carotid arteries.
European journal of clinical investigation 2005;35(11):669-76.
2005: Erkkilä Arja T; Närvänen Outi; Lehto Seppo; Uusitupa Matti I J; Ylä-Herttuala Seppo
Antibodies against oxidized LDL and cardiolipin and mortality in patients with coronary heart disease.
Atherosclerosis 2005;183(1):157-62.
2005: Leppänen Pia; Koota Suvi; Kholová Ivana; Koponen Jonna; Fieber Christina; Eriksson Ulf; Alitalo Kari; Ylä-Herttuala Seppo
Gene transfers of vascular endothelial growth factor-A, vascular endothelial growth factor-B, vascular endothelial growth factor-C, and vascular endothelial growth factor-D have no effects on atherosclerosis in hypercholesterolemic low-density lipoprotein-receptor/apolipoprotein B48-deficient mice.
Circulation 2005;112(9):1347-52.
2005: Pajusola Katri; Künnapuu Jaana; Vuorikoski Sanna; Soronen Jarkko; André Helder; Pereira Teresa; Korpisalo Petra; Ylä-Herttuala Seppo; Poellinger Lorenz; Alitalo Kari
Stabilized HIF-1alpha is superior to VEGF for angiogenesis in skeletal muscle via adeno-associated virus gene transfer.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(10):1365-7.
2005: Heikkilä Annaleena; Tuomisto Tiina; Häkkinen Sanna-Kaisa; Keski-Nisula Leea; Heinonen Seppo; Ylä-Herttuala Seppo
Tumor suppressor and growth regulatory genes are overexpressed in severe early-onset preeclampsia--an array study on case-specific human preeclamptic placental tissue.
Acta obstetricia et gynecologica Scandinavica 2005;84(7):679-89.
2005: Tuomisto Tiina T; Riekkinen Mervi S; Viita Helena; Levonen Anna-Liisa; Ylä-Herttuala Seppo
Analysis of gene and protein expression during monocyte-macrophage differentiation and cholesterol loading--cDNA and protein array study.
Atherosclerosis 2005;180(2):283-91.
2005: Krebs Rainer; Tikkanen Jussi M; Nykänen Antti I; Wood Jeanette; Jeltsch Michael; Ylä-Herttuala Seppo; Koskinen Petri K; Lemström Karl B
Dual role of vascular endothelial growth factor in experimental obliterative bronchiolitis.
American journal of respiratory and critical care medicine 2005;171(12):1421-9.
2005: Rutanen J; Turunen A-M; Teittinen M; Rissanen T T; Heikura T; Koponen J K; Gruchala M; Inkala M; Jauhiainen S; Hiltunen M O; Turunen M P; Stacker S A; Achen M G; Ylä-Herttuala S
Gene transfer using the mature form of VEGF-D reduces neointimal thickening through nitric oxide-dependent mechanism.
Gene therapy 2005;12(12):980-7.
2005: Puhakka Hanna L; Turunen Päivi; Gruchala Marcin; Bursill Christine; Heikura Tommi; Vajanto Ismo; Greaves David R; Channons Keith; Ylä-Herttuala Seppo
Effects of vaccinia virus anti-inflammatory protein 35K and TIMP-1 gene transfers on vein graft stenosis in rabbits.
In vivo (Athens, Greece) 2005;19(3):515-21.
2005: Tuomisto Tiina T; Ylä-Herttuala Seppo
What have we learnt about microarray analyses of atherogenesis?
Current opinion in lipidology 2005;16(2):201-5.
2005: Katsube Kosuke; Bishop Allen T; Simari Robert D; Ylä-Herttuala Seppo; Friedrich Patricia F
Vascular endothelial growth factor (VEGF) gene transfer enhances surgical revascularization of necrotic bone.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2005;23(2):469-74.
2005: Turunen Päivi; Puhakka Hanna; Rutanen Juha; Hiltunen Mikko O; Heikura Tommi; Gruchala Marcin; Ylä-Herttuala Seppo
Intravascular adenovirus-mediated lipoprotein-associated phospholipase A2 gene transfer reduces neointima formation in balloon-denuded rabbit aorta.
Atherosclerosis 2005;179(1):27-33.
2005: Salminen Mirka; Airenne Kari J; Rinnankoski Rita; Reimari Jenni; Välilehto Outi; Rinne Johanna; Suikkanen Sanna; Kukkonen Sari; Ylä-Herttuala Seppo; Kulomaa Markku S; Vihinen-Ranta Maija
Improvement in nuclear entry and transgene expression of baculoviruses by disintegration of microtubules in human hepatocytes.
Journal of virology 2005;79(5):2720-8.
2005: Bhardwaj S; Roy H; Kärpänen T; He Y; Jauhiainen S; Hedman M; Alitalo K; Ylä-Herttuala S
Periadventitial angiopoietin-1 gene transfer induces angiogenesis in rabbit carotid arteries.
Gene therapy 2005;12(5):388-94.
2005: Baluk Peter; Tammela Tuomas; Ator Erin; Lyubynska Natalya; Achen Marc G; Hicklin Daniel J; Jeltsch Michael; Petrova Tatiana V; Pytowski Bronislaw; Stacker Steven A; Ylä-Herttuala Seppo; Jackson David G; Alitalo Kari; McDonald Donald M
Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation.
The Journal of clinical investigation 2005;115(2):247-57.
2005: Markkanen Johanna E; Rissanen Tuomas T; Kivelä Antti; Ylä-Herttuala Seppo
Growth factor-induced therapeutic angiogenesis and arteriogenesis in the heart--gene therapy.
Cardiovascular research 2005;65(3):656-64.
2005: Tuomisto Tiina T; Binder Bernd R; Ylä-Herttuala Seppo
Genetics, genomics and proteomics in atherosclerosis research.
Annals of medicine 2005;37(5):323-32.
2005: Ruponen Marika; Hyvönen Zanna; Urtti Arto; Ylä-Herttuala Seppo
Nonviral gene delivery methods in cardiovascular diseases.
Methods in molecular medicine 2005;108():315-28.
2005: Koponen Jonna K; Ylä-Herttuala Seppo
[How to make scar tissue in cardiac muscle beat?]
Duodecim; lääketieteellinen aikakauskirja 2005;121(11):1199-201.
2005: Laitinen Olli H; Airenne Kari J; Hytönen Vesa P; Peltomaa Erik; Mähönen Anssi J; Wirth Thomas; Lind Miia M; Mäkelä Kari A; Toivanen Pyry I; Schenkwein Diana; Heikura Tommi; Nordlund Henri R; Kulomaa Markku S; Ylä-Herttuala Seppo
A multipurpose vector system for the screening of libraries in bacteria, insect and mammalian cells and expression in vivo.
Nucleic acids research 2005;33(4):e42.
2004: Hytönen Vesa P; Laitinen Olli H; Airenne Tomi T; Kidron Heidi; Meltola Niko J; Porkka Eevaleena J; Hörhä Jarno; Paldanius Tiina; Määttä Juha A E; Nordlund Henri R; Johnson Mark S; Salminen Tiina A; Airenne Kari J; Ylä-Herttuala Seppo; Kulomaa Markku S
Efficient production of active chicken avidin using a bacterial signal peptide in Escherichia coli.
The Biochemical journal 2004;384(Pt 2):385-90.
2004: Ylä-Herttuala Seppo; Markkanen Johanna E; Rissanen Tuomas T
Gene therapy for ischemic cardiovascular diseases: some lessons learned from the first clinical trials.
Trends in cardiovascular medicine 2004;14(8):295-300.
2004: Immonen Arto; Vapalahti Matti; Tyynelä Kristiina; Hurskainen Heleena; Sandmair Anu; Vanninen Ritva; Langford Gillian; Murray Neil; Ylä-Herttuala Seppo
AdvHSV-tk gene therapy with intravenous ganciclovir improves survival in human malignant glioma: a randomised, controlled study.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;10(5):967-72.
2004: Aburawi Elhadi; Liuba Petru; Pesonen Erkki; Ylä-Herttuala Seppo; Sjöblad Sture
Acute respiratory viral infections aggravate arterial endothelial dysfunction in children with type 1 diabetes.
Diabetes care 2004;27(11):2733-5.
2004: Petrova Tatiana V; Karpanen Terhi; Norrmén Camilla; Mellor Russell; Tamakoshi Tomoki; Finegold David; Ferrell Robert; Kerjaschki Dontscho; Mortimer Peter; Ylä-Herttuala Seppo; Miura Naoyuki; Alitalo Kari
Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis.
Nature medicine 2004;10(9):974-81.
2004: Turunen Päivi; Jalkanen Johanna; Heikura Tommi; Puhakka Hanna; Karppi Jouni; Nyyssönen Kristiina; Ylä-Herttuala Seppo
Adenovirus-mediated gene transfer of Lp-PLA2 reduces LDL degradation and foam cell formation in vitro.
Journal of lipid research 2004;45(9):1633-9.
2004: Mähönen Anssi J; Airenne Kari J; Lind Miia M; Lesch Hanna P; Ylä-Herttuala Seppo
Optimized self-excising Cre-expression cassette for mammalian cells.
Biochemical and biophysical research communications 2004;320(2):366-71.
2004: Tuomisto Tiina T; Rissanen Tuomas T; Vajanto Ismo; Korkeela Anna; Rutanen Juha; Ylä-Herttuala Seppo
HIF-VEGF-VEGFR-2, TNF-alpha and IGF pathways are upregulated in critical human skeletal muscle ischemia as studied with DNA array.
Atherosclerosis 2004;174(1):111-20.
2004: Gruchala Marcin; Bhardwaj Shalini; Pajusola Katri; Roy Himadri; Rissanen Tuomas T; Kokina Ilze; Kholová Ivana; Markkanen Johanna E; Rutanen Juha; Heikura Tommi; Alitalo Kari; Büeler Hansruedi; Ylä-Herttuala Seppo
Gene transfer into rabbit arteries with adeno-associated virus and adenovirus vectors.
The journal of gene medicine 2004;6(5):545-54.
2004: Koskinen Kaisa; Vainio Petri J; Smith David J; Pihlavisto Marjo; Ylä-Herttuala Seppo; Jalkanen Sirpa; Salmi Marko
Granulocyte transmigration through the endothelium is regulated by the oxidase activity of vascular adhesion protein-1 (VAP-1).
Blood 2004;103(9):3388-95.
2004: Kankkonen Hanna M; Vähäkangas Elisa; Marr Robert A; Pakkanen Timo; Laurema Anniina; Leppänen Pia; Jalkanen Johanna; Verma Inder M; Ylä-Herttuala Seppo
Long-term lowering of plasma cholesterol levels in LDL-receptor-deficient WHHL rabbits by gene therapy.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;9(4):548-56.
2004: Valonen Piia K; Lehtimäki Kimmo K; Väisänen Tuula H; Kettunen Mikko I; Gröhn Olli H J; Ylä-Herttuala Seppo; Kauppinen Risto A
Water diffusion in a rat glioma during ganciclovir-thymidine kinase gene therapy-induced programmed cell death in vivo: correlation with cell density.
Journal of magnetic resonance imaging : JMRI 2004;19(4):389-96.
2004: Kankkonen Hanna M; Turunen Mikko P; Hiltunen Mikko O; Lehtolainen Pauliina; Koponen Jonna; Leppänen Pia; Turunen Anna-Mari; Ylä-Herttuala Seppo
Feline immunodeficiency virus and retrovirus-mediated adventitial ex vivo gene transfer to rabbit carotid artery using autologous vascular smooth muscle cells.
Journal of molecular and cellular cardiology 2004;36(3):333-41.
2004: Rutanen Juha; Rissanen Tuomas T; Markkanen Johanna E; Gruchala Marcin; Silvennoinen Päivi; Kivelä Antti; Hedman Antti; Hedman Marja; Heikura Tommi; Ordén Maija-Riitta; Stacker Steven A; Achen Marc G; Hartikainen Juha; Ylä-Herttuala Seppo
Adenoviral catheter-mediated intramyocardial gene transfer using the mature form of vascular endothelial growth factor-D induces transmural angiogenesis in porcine heart.
Circulation 2004;109(8):1029-35.
2004: Leppänen Olli; Rutanen Juha; Hiltunen Mikko O; Rissanen Tuomas T; Turunen Mikko P; Sjöblom Tobias; Brüggen Josef; Bäckström Gudrun; Carlsson Marianne; Buchdunger Elisabeth; Bergqvist David; Alitalo Kari; Heldin Carl-Henrik; Ostman Arne; Ylä-Herttuala Seppo
Oral imatinib mesylate (STI571/gleevec) improves the efficacy of local intravascular vascular endothelial growth factor-C gene transfer in reducing neointimal growth in hypercholesterolemic rabbits.
Circulation 2004;109(9):1140-6.
2004: Tuhkanen Hanna; Anttila Maarit; Kosma Veli-Matti; Ylä-Herttuala Seppo; Heinonen Seppo; Kuronen Arja; Juhola Matti; Tammi Raija; Tammi Markku; Mannermaa Arto
Genetic alterations in the peritumoral stromal cells of malignant and borderline epithelial ovarian tumors as indicated by allelic imbalance on chromosome 3p.
International journal of cancer. Journal international du cancer 2004;109(2):247-52.
2004: Räty Jani K; Airenne Kari J; Marttila Ari T; Marjomäki Varpu; Hytönen Vesa P; Lehtolainen Pauliina; Laitinen Olli H; Mähönen Anssi J; Kulomaa Markku S; Ylä-Herttuala Seppo
Enhanced gene delivery by avidin-displaying baculovirus.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;9(2):282-91.
2004: Laurema Anniina; Vanamo Kari; Heikkilä Annaleena; Riekkinen Mervi; Heinonen Seppo; Ylä-Herttuala Seppo
Fetal membranes act as a barrier for adenoviruses: gene transfer into exocoelomic cavity of rat fetuses does not affect cells in the fetus.
American journal of obstetrics and gynecology 2004;190(1):264-7.
2004: Banning Antje; Schnurr Kerstin; Böl Gaby Fleur; Kupper Dagmar; Müller-Schmehl Katrin; Viita Helena; Ylä-Herttuala Seppo; Brigelius-Flohé Regina
Inhibition of basal and interleukin-1-induced VCAM-1 expression by phospholipid hydroperoxide glutathione peroxidase and 15-lipoxygenase in rabbit aortic smooth muscle cells.
Free radical biology & medicine 2004;36(2):135-44.
2004: Rissanen Tuomas T; Rutanen Juha; Ylä-Herttuala Seppo
Gene transfer for therapeutic vascular growth in myocardial and peripheral ischemia.
Advances in genetics 2004;52():117-64.
2004: Gruchala Marcin; Roy Himadri; Bhardwaj Shalini; Ylä-Herttuala Seppo
Gene therapy for cardiovascular diseases.
Current pharmaceutical design 2004;10(4):407-23.
2003: Jalkanen Johanna; Leppänen Pia; Pajusola Katri; Närvänen Outi; Mähönen Anssi; Vähäkangas Elisa; Greaves David R; Büeler Hansruedi; Ylä-Herttuala Seppo
Adeno-associated virus-mediated gene transfer of a secreted decoy human macrophage scavenger receptor reduces atherosclerotic lesion formation in LDL receptor knockout mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;8(6):903-10.
2003: Lehtolainen P; Wirth T; Taskinen A K; Lehenkari P; Leppänen O; Lappalainen M; Pulkkanen K; Marttila A; Marjomäki V; Airenne K J; Horton M; Kulomaa M S; Ylä-Herttuala S
Targeting of biotinylated compounds to its target tissue using a low-density lipoprotein receptor-avidin fusion protein.
Gene therapy 2003;10(25):2090-7.
2003: Tuomisto Tiina T; Korkeela Anna; Rutanen Juha; Viita Helena; Bräsen Jan H; Riekkinen Mervi S; Rissanen Tuomas T; Karkola Kari; Kiraly Zsolt; Kölble Konrad; Ylä-Herttuala Seppo
Gene expression in macrophage-rich inflammatory cell infiltrates in human atherosclerotic lesions as studied by laser microdissection and DNA array: overexpression of HMG-CoA reductase, colony stimulating factor receptors, CD11A/CD18 integrins, and interleukin receptors.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(12):2235-40.
2003: Gröhn Olli H J; Valonen Piia K; Lehtimäki Kimmo K; Väisänen Tuula H; Kettunen Mikko I; Ylä-Herttuala Seppo; Kauppinen Risto A; Garwood Michael
Novel magnetic resonance imaging contrasts for monitoring response to gene therapy in rat glioma.
Cancer research 2003;63(22):7571-4.
2003: Kleiman Neal S; Patel Nirav C; Allen Keith B; Simons Michael; Ylä-Herttuala Seppo; Griffin Elaine; Dzau Victor J
Evolving revascularization approaches for myocardial ischemia.
The American journal of cardiology 2003;92(9B):9N-17N.
2003: Kukkonen Sari P; Airenne Kari J; Marjomäki Varpu; Laitinen Olli H; Lehtolainen Pauliina; Kankaanpää Pasi; Mähönen Anssi J; Räty Jani K; Nordlund Henri R; Oker-Blom Christian; Kulomaa Markku S; Ylä-Herttuala Seppo
Baculovirus capsid display: a novel tool for transduction imaging.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;8(5):853-62.
2003: Lampela Pasi; Huotari Marko; Harjula Anu; Oinonen Lasse; Ustav Mart; Ylä-Herttuala Seppo; Männistö Pekka T; Raasmaja Atso
Production of functional recombinant tyrosine hydroxylase by the BPV-1 expression plasmids in the cell cultures.
Plasmid 2003;50(3):230-5.
2003: Lehtimäki Kimmo K; Valonen Piia K; Griffin Julian L; Väisänen Tuula H; Gröhn Olli H J; Kettunen Mikko I; Vepsäläinen Jouko; Ylä-Herttuala Seppo; Nicholson Jeremy; Kauppinen Risto A
Metabolite changes in BT4C rat gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death as studied by 1H NMR spectroscopy in vivo, ex vivo, and in vitro.
The Journal of biological chemistry 2003;278(46):45915-23.
2003: Bhardwaj Shalini; Roy Himadri; Gruchala Marcin; Viita Helena; Kholova Ivana; Kokina Ilze; Achen Marc G; Stacker Steven A; Hedman Marja; Alitalo Kari; Ylä-Herttuala Seppo
Angiogenic responses of vascular endothelial growth factors in periadventitial tissue.
Human gene therapy 2003;14(15):1451-62.
2003: Ylä-Herttuala Seppo
Percutaneous transcoronary venous access for cellular cardiomyoplasty.
Lancet 2003;362(9392):1252.
2003: Rutanen Juha; Leppänen Pia; Tuomisto Tiina T; Rissanen Tuomas T; Hiltunen Mikko O; Vajanto Ismo; Niemi Mari; Häkkinen Tomi; Karkola Kari; Stacker Steven A; Achen Marc G; Alitalo Kari; Ylä-Herttuala Seppo
Vascular endothelial growth factor-D expression in human atherosclerotic lesions.
Cardiovascular research 2003;59(4):971-9.
2003: Hiltunen Mikko O; Ylä-Herttuala Seppo
DNA methylation, smooth muscle cells, and atherogenesis.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(10):1750-3.
2003: Airenne Kari J; Peltomaa Erik; Hytönen Vesa P; Laitinen Olli H; Ylä-Herttuala Seppo
Improved generation of recombinant baculovirus genomes in Escherichia coli.
Nucleic acids research 2003;31(17):e101.
2003: Jalkanen Johanna; Leppänen Pia; Närvänen Outi; Greaves David R; Ylä-Herttuala Seppo
Adenovirus-mediated gene transfer of a secreted decoy human macrophage scavenger receptor (SR-AI) in LDL receptor knock-out mice.
Atherosclerosis 2003;169(1):95-103.
2003: Tarkka Tatu; Sipola Annina; Jämsä Timo; Soini Ylermi; Ylä-Herttuala Seppo; Tuukkanen Juha; Hautala Timo
Adenoviral VEGF-A gene transfer induces angiogenesis and promotes bone formation in healing osseous tissues.
The journal of gene medicine 2003;5(7):560-6.
2003: Griffin Julian L; Lehtimäki Kimmo K; Valonen Piia K; Gröhn Olli H J; Kettunen Mikko I; Ylä-Herttuala Seppo; Pitkänen Asla; Nicholson Jeremy K; Kauppinen Risto A
Assignment of 1H nuclear magnetic resonance visible polyunsaturated fatty acids in BT4C gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death.
Cancer research 2003;63(12):3195-201.
2003: Ylä-Herttuala Seppo; Alitalo Kari
Gene transfer as a tool to induce therapeutic vascular growth.
Nature medicine 2003;9(6):694-701.
2003: Hedman Marja; Hartikainen Juha; Syvänne Mikko; Stjernvall Joachim; Hedman Antti; Kivelä Antti; Vanninen Esko; Mussalo Hanna; Kauppila Esa; Simula Sakari; Närvänen Outi; Rantala Arto; Peuhkurinen Keijo; Nieminen Markku S; Laakso Markku; Ylä-Herttuala Seppo
Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: phase II results of the Kuopio Angiogenesis Trial (KAT).
Circulation 2003;107(21):2677-83.
2003: Hiltunen Mikko Olavi; Ruuskanen Markku; Huuskonen Jouni; Mähönen Anssi Juhani; Ahonen Mari; Rutanen Juha; Kosma Veli-Matti; Mahonen Anitta; Kröger Heikki; Ylä-Herttuala Seppo
Adenovirus-mediated VEGF-A gene transfer induces bone formation in vivo.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(9):1147-9.
2003: Rissanen Tuomas T; Markkanen Johanna E; Gruchala Marcin; Heikura Tommi; Puranen Antti; Kettunen Mikko I; Kholová Ivana; Kauppinen Risto A; Achen Marc G; Stacker Steven A; Alitalo Kari; Ylä-Herttuala Seppo
VEGF-D is the strongest angiogenic and lymphangiogenic effector among VEGFs delivered into skeletal muscle via adenoviruses.
Circulation research 2003;92(10):1098-106.
2003: Laurema A; Heikkilä A; Keski-Nisula L; Heikura T; Lehtolainen P; Manninen H; Tuomisto T T; Heinonen S; Ylä-Herttuala S
Transfection of oocytes and other types of ovarian cells in rabbits after direct injection into uterine arteries of adenoviruses and plasmid/liposomes.
Gene therapy 2003;10(7):580-4.
2003: Liuba Petru; Pesonen Erkki; Paakkari Ilari; Batra Satish; Andersen Leif; Forslid Anders; Ylä-Herttuala Seppo; Persson Kenneth; Wadström Torkel; Wang Xin; Laurini Ricardo
Co-infection with Chlamydia pneumoniae and Helicobacter pylori results in vascular endothelial dysfunction and enhanced VCAM-1 expression in apoE-knockout mice.
Journal of vascular research 2003;40(2):115-22.
2003: Liuba Petru; Persson Jerker; Luoma Jukka; Ylä-Herttuala Seppo; Pesonen Erkki
Acute infections in children are accompanied by oxidative modification of LDL and decrease of HDL cholesterol, and are followed by thickening of carotid intima-media.
European heart journal 2003;24(6):515-21.
2003: Nykänen Antti I; Krebs Rainer; Saaristo Anne; Turunen Päivi; Alitalo Kari; Ylä-Herttuala Seppo; Koskinen Petri K; Lemström Karl B
Angiopoietin-1 protects against the development of cardiac allograft arteriosclerosis.
Circulation 2003;107(9):1308-14.
2003: Koponen J K; Kankkonen H; Kannasto J; Wirth T; Hillen W; Bujard H; Ylä-Herttuala S
Doxycycline-regulated lentiviral vector system with a novel reverse transactivator rtTA2S-M2 shows a tight control of gene expression in vitro and in vivo.
Gene therapy 2003;10(6):459-66.
2003: Niskanen L; Lindi V; Erkkilä A; Sivenius K; Luoma J; Ylä-Herttuala S; Laakso M; Uusitupa M I j
Association of the PRO12ALA polymorphism of the PPAR-gamma2 gene with oxidized low-density lipoprotein and cardiolipin autoantibodies in nondiabetic and type 2 diabetic subjects.
Metabolism: clinical and experimental 2003;52(2):213-7.
2003: Kossila Maija; Pihlajamäki Jussi; Kärkkäinen Päivi; Miettinen Raija; Kekäläinen Päivi; Vauhkonen Ilkka; Ylä-Herttuala Seppo; Laakso Markku
Promoter polymorphisms -359T/C and -303A/G of the catalytic subunit p110beta gene of human phosphatidylinositol 3-kinase are not associated with insulin secretion or insulin sensitivity in finnish subjects.
Diabetes care 2003;26(1):179-82.
2003: Bräsen Jan Hinrich; Häkkinen Tomi; Malle Ernst; Beisiegel Ulrike; Ylä-Herttuala Seppo
Patterns of oxidized epitopes, but not NF-kappa B expression, change during atherogenesis in WHHL rabbits.
Atherosclerosis 2003;166(1):13-21.
2003: Rissanen Tuomas T; Markkanen Johanna E; Arve Katja; Rutanen Juha; Kettunen Mikko I; Vajanto Ismo; Jauhiainen Suvi; Cashion Linda; Gruchala Marcin; Närvänen Outi; Taipale Pekka; Kauppinen Risto A; Rubanyi Gabor M; Ylä-Herttuala Seppo
Fibroblast growth factor 4 induces vascular permeability, angiogenesis and arteriogenesis in a rabbit hindlimb ischemia model.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(1):100-2.
2003: Ylä-Herttuala S
Angiogenesis clinical trials.
Ernst Schering Research Foundation workshop 2003;(43):19-23.
2002: Lehtolainen P; Tyynelä K; Kannasto J; Airenne K J; Ylä-Herttuala S
Baculoviruses exhibit restricted cell type specificity in rat brain: a comparison of baculovirus- and adenovirus-mediated intracerebral gene transfer in vivo.
Gene therapy 2002;9(24):1693-9.
2002: Rutanen J; Puhakka H; Ylä-Herttuala S
Post-intervention vessel remodeling.
Gene therapy 2002;9(22):1487-91.
2002: Pajusola Katri; Gruchala Marcin; Joch Hana; Lüscher Thomas F; Ylä-Herttuala Seppo; Büeler Hansruedi
Cell-type-specific characteristics modulate the transduction efficiency of adeno-associated virus type 2 and restrain infection of endothelial cells.
Journal of virology 2002;76(22):11530-40.
2002: Tyynelä Kristiina; Sandmair Anu-Maaria; Turunen Marita; Vanninen Ritva; Vainio Pauli; Kauppinen Risto; Johansson Risto; Vapalahti Matti; Ylä-Herttuala Seppo
Adenovirus-mediated herpes simplex virus thymidine kinase gene therapy in BT4C rat glioma model.
Cancer gene therapy 2002;9(11):917-24.
2002: Hiltunen Mikko O; Tuomisto Tiina T; Niemi Mari; Bräsen Jan H; Rissanen Tuomas T; Törönen Petri; Vajanto Ismo; Ylä-Herttuala Seppo
Changes in gene expression in atherosclerotic plaques analyzed using DNA array.
Atherosclerosis 2002;165(1):23-32.
2002: Saaristo Anne; Veikkola Tanja; Tammela Tuomas; Enholm Berndt; Karkkainen Marika J; Pajusola Katri; Bueler Hansruedi; Ylä-Herttuala Seppo; Alitalo Kari
Lymphangiogenic gene therapy with minimal blood vascular side effects.
The Journal of experimental medicine 2002;196(6):719-30.
2002: Turunen Mikko P; Puhakka Hanna L; Koponen Jonna K; Hiltunen Mikko O; Rutanen Juha; Leppänen Olli; Turunen Anna-Mari; Närvänen Ale; Newby Andrew C; Baker Andrew H; Ylä-Herttuala Seppo
Peptide-retargeted adenovirus encoding a tissue inhibitor of metalloproteinase-1 decreases restenosis after intravascular gene transfer.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(3):306-12.
2002: Petrova Tatiana V; Mäkinen Taija; Mäkelä Tomi P; Saarela Janna; Virtanen Ismo; Ferrell Robert E; Finegold David N; Kerjaschki Dontscho; Ylä-Herttuala Seppo; Alitalo Kari
Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor.
The EMBO journal 2002;21(17):4593-9.
2002: Bräsen Jan Hinrich; Koenig Kai; Bach Heiko; Kontush Anatol; Heinle Helmut; Witting Paul K; Ylä-Herttuala Seppo; Stocker Roland; Beisiegel Ulrike
Comparison of the effects of alpha-tocopherol, ubiquinone-10 and probucol at therapeutic doses on atherosclerosis in WHHL rabbits.
Atherosclerosis 2002;163(2):249-59.
2002: Vajanto Ismo; Rissanen Tuomas T; Rutanen Juha; Hiltunen Mikko O; Tuomisto Tiina T; Arve Katja; Närvänen Outi; Manninen Hannu; Räsänen Heikki; Hippeläinen Mikko; Alhava Esko; Ylä-Herttuala Seppo
Evaluation of angiogenesis and side effects in ischemic rabbit hindlimbs after intramuscular injection of adenoviral vectors encoding VEGF and LacZ.
The journal of gene medicine 2002;4(4):371-80.
2002: Mäkinen Kimmo; Manninen Hannu; Hedman Marja; Matsi Pekka; Mussalo Hanna; Alhava Esko; Ylä-Herttuala Seppo
Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: a randomized, placebo-controlled, double-blinded phase II study.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(1):127-33.
2002: Saaristo Anne; Veikkola Tanja; Enholm Berndt; Hytönen Maija; Arola Johanna; Pajusola Katri; Turunen Païvi; Jeltsch Michael; Karkkainen Marika J; Kerjaschki Dontscho; Bueler Hansruedi; Ylä-Herttuala Seppo; Alitalo Kari
Adenoviral VEGF-C overexpression induces blood vessel enlargement, tortuosity, and leakiness but no sprouting angiogenesis in the skin or mucous membranes.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(9):1041-9.
2002: Lemström Karl B; Krebs Rainer; Nykänen Antti I; Tikkanen Jussi M; Sihvola Roope K; Aaltola Eva M; Häyry Pekka J; Wood Jeanette; Alitalo Kari; Ylä-Herttuala Seppo; Koskinen Petri K
Vascular endothelial growth factor enhances cardiac allograft arteriosclerosis.
Circulation 2002;105(21):2524-30.
2002: Heikkilä Annaleena; Myllynen Päivi; Keski-Nisula Leea; Heinonen Seppo; Vähäkangas Kirsi; Ylä-Herttuala Seppo
Gene transfer to human placenta ex vivo: a novel application of dual perfusion of human placental cotyledon.
American journal of obstetrics and gynecology 2002;186(5):1046-51.
2002: Hakumäki Juhana M; Gröhn Olli H J; Tyynelä Kristiina; Valonen Piia; Ylä-Herttuala Seppo; Kauppinen Risto A
Early gene therapy-induced apoptotic response in BT4C gliomas by magnetic resonance relaxation contrast T1 in the rotating frame.
Cancer gene therapy 2002;9(4):338-45.
2002: Rissanen Tuomas T; Vajanto Ismo; Hiltunen Mikko O; Rutanen Juha; Kettunen Mikko I; Niemi Mari; Leppänen Pia; Turunen Mikko P; Markkanen Johanna E; Arve Katja; Alhava Esko; Kauppinen Risto A; Ylä-Herttuala Seppo
Expression of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 (KDR/Flk-1) in ischemic skeletal muscle and its regeneration.
The American journal of pathology 2002;160(4):1393-403.
2002: Lampela Pasi; Räisänen Johanna; Männistö Pekka T; Ylä-Herttuala Seppo; Raasmaja Atso
The use of low-molecular-weight PEIs as gene carriers in the monkey fibroblastoma and rabbit smooth muscle cell cultures.
The journal of gene medicine 2002;4(2):205-14.
2002: Koponen Jonna K; Turunen Anna-Mari; Ylä-Herttuala Seppo
Escherichia coli DNA contamination in AmpliTaq Gold polymerase interferes with TaqMan analysis of lacZ.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(3):220-2.
2002: Lehtolainen Pauliina; Taskinen Anna; Laukkanen Johanna; Airenne Kari J; Heino Sanna; Lappalainen Maarit; Ojala Kirsi; Marjomäki Varpu; Martin John F; Kulomaa Markku S; Ylä-Herttuala Seppo
Cloning and characterization of Scavidin, a fusion protein for the targeted delivery of biotinylated molecules.
The Journal of biological chemistry 2002;277(10):8545-50.
2002: Hiltunen Mikko O; Turunen Mikko P; Häkkinen Tomi P; Rutanen Juha; Hedman Maria; Mäkinen Kimmo; Turunen Anna-Mari; Aalto-Setälä Katriina; Ylä-Herttuala Seppo
DNA hypomethylation and methyltransferase expression in atherosclerotic lesions.
Vascular medicine (London, England) 2002;7(1):5-11.
2002: Kossila Maija; Jauhiainen Suvi; Laukkanen Mikko O; Lehtolainen Pauliina; Jääskeläinen Maiju; Turunen Päivi; Loimas Sami; Wahlfors Jarmo; Ylä-Herttuala Seppo
Improvement in adenoviral gene transfer efficiency after preincubation at +37 degrees C in vitro and in vivo.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(1):87-93.
2002: Rutanen Juha; Markkanen Johanna; Ylä-Herttuala Seppo
Gene therapy for restenosis: current status.
Drugs 2002;62(11):1575-85.
2002: Laukkanen Johanna; Ylä-Herttuala Seppo
Cloning and characterization of soluble decoy receptors.
Methods in enzymology 2002;353():337-45.
2002: Laukkanen Johanna; Ylä-Herttuala Seppo
Genes involved in atherosclerosis.
Experimental nephrology 2002;10(2):150-63.
2002: Hiltunen Mikko O; Turunen Mikko P; Ylä-Herttuala Seppo
Gene therapy methods in cardiovascular diseases.
Methods in enzymology 2002;346():311-20.
2001: Bräsen J H; Kivelä A; Röser K; Rissanen T T; Niemi M; Luft F C; Donath K; Ylä-Herttuala S
Angiogenesis, vascular endothelial growth factor and platelet-derived growth factor-BB expression, iron deposition, and oxidation-specific epitopes in stented human coronary arteries.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(11):1720-6.
2001: Sentman M L; Brännström T; Westerlund S; Laukkanen M O; Ylä-Herttuala S; Basu S; Marklund S L
Extracellular superoxide dismutase deficiency and atherosclerosis in mice.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(9):1477-82.
2001: Närvänen O; Erkkilä A; Ylä-Herttuala S
Evaluation and characterization of EIA measuring autoantibodies against oxidized LDL.
Free radical biology & medicine 2001;31(6):769-77.
2001: Rissanen T T; Vajanto I; Ylä-Herttuala S
Gene therapy for therapeutic angiogenesis in critically ischaemic lower limb - on the way to the clinic.
European journal of clinical investigation 2001;31(8):651-66.
2001: Laukkanen M O; Leppänen P; Turunen P; Porkkala-Sarataho E; Salonen J T; Ylä-Herttuala S
Gene transfer of extracellular superoxide dismutase to atherosclerotic mice.
Antioxidants & redox signaling 2001;3(3):397-402.
2001: Heikkilä A; Hiltunen M O; Turunen M P; Keski-Nisula L; Turunen A M; Räsänen H; Rissanen T T; Kosma V M; Manninen H; Heinonen S; Ylä-Herttuala S
Angiographically guided utero-placental gene transfer in rabbits with adenoviruses, plasmid/liposomes and plasmid/polyethyleneimine complexes.
Gene therapy 2001;8(10):784-8.
2001: Leppänen P M; Koponen J; Turunen M P; Pakkanen T; Ylä-Herttuala S
Optimized in situ PCR method for the detection of gene transfer vector in histological sections.
The journal of gene medicine 2001;3(2):173-8.
2001: Karpanen T; Egeblad M; Karkkainen M J; Kubo H; Ylä-Herttuala S; Jäättelä M; Alitalo K
Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth.
Cancer research 2001;61(5):1786-90.
2001: Mäkinen T; Jussila L; Veikkola T; Karpanen T; Kettunen M I; Pulkkanen K J; Kauppinen R; Jackson D G; Kubo H; Nishikawa S; Ylä-Herttuala S; Alitalo K
Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3.
Nature medicine 2001;7(2):199-205.
2001: Hiltunen T P; Gough P J; Greaves D R; Gordon S; Ylä-Herttuala S
Rabbit atherosclerotic lesions express scavenger receptor AIII mRNA, a naturally occurring splice variant that encodes a non-functional, dominant negative form of the macrophage scavenger receptor.
Atherosclerosis 2001;154(2):415-9.
2001: Rutanen J; Rissanen T T; Kivelä A; Vajanto I; Ylä-Herttuala S
Clinical applications of vascular gene therapy.
Current cardiology reports 2001;3(1):29-36.
2000: Sandmair A M; Loimas S; Puranen P; Immonen A; Kossila M; Puranen M; Hurskainen H; Tyynelä K; Turunen M; Vanninen R; Lehtolainen P; Paljärvi L; Johansson R; Vapalahti M; Ylä-Herttuala S
Thymidine kinase gene therapy for human malignant glioma, using replication-deficient retroviruses or adenoviruses.
Human gene therapy 2000;11(16):2197-205.
2000: Hiltunen M O; Turunen M P; Turunen A M; Rissanen T T; Laitinen M; Kosma V M; Ylä-Herttuala S
Biodistribution of adenoviral vector to nontarget tissues after local in vivo gene transfer to arterial wall using intravascular and periadventitial gene delivery methods.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(14):2230-6.
2000: Häkkinen T; Karkola K; Ylä-Herttuala S
Macrophages, smooth muscle cells, endothelial cells, and T-cells express CD40 and CD40L in fatty streaks and more advanced human atherosclerotic lesions. Colocalization with epitopes of oxidized low-density lipoprotein, scavenger receptor, and CD16 (Fc gammaRIII).
Virchows Archiv : an international journal of pathology 2000;437(4):396-405.
2000: Hiltunen M O; Laitinen M; Turunen M P; Jeltsch M; Hartikainen J; Rissanen T T; Laukkanen J; Niemi M; Kossila M; Häkkinen T P; Kivelä A; Enholm B; Mansukoski H; Turunen A M; Alitalo K; Ylä-Herttuala S
Intravascular adenovirus-mediated VEGF-C gene transfer reduces neointima formation in balloon-denuded rabbit aorta.
Circulation 2000;102(18):2262-8.
2000: Kossila M; Sinkovic M; Kärkkäinen P; Laukkanen M O; Miettinen R; Rissanen J; Kekäläinen P; Kuusisto J; Ylä-Herttuala S; Laakso M
Gene encoding the catalytic subunit p110beta of human phosphatidylinositol 3-kinase: cloning, genomic structure, and screening for variants in patients with type 2 diabetes.
Diabetes 2000;49(10):1740-3.
2000: Brigelius-Flohé R; Maurer S; Lötzer K; Böl G; Kallionpää H; Lehtolainen P; Viita H; Ylä-Herttuala S
Overexpression of PHGPx inhibits hydroperoxide-induced oxidation, NFkappaB activation and apoptosis and affects oxLDL-mediated proliferation of rabbit aortic smooth muscle cells.
Atherosclerosis 2000;152(2):307-16.
2000: Hedman M; Ylä-Herttuala S
Gene therapy for the treatment of peripheral vascular disease and coronary artery disease.
Drugs of today (Barcelona, Spain : 1998) 2000;36(9):609-17.
2000: Airenne K J; Hiltunen M O; Turunen M P; Turunen A M; Laitinen O H; Kulomaa M S; Ylä-Herttuala S
Baculovirus-mediated periadventitial gene transfer to rabbit carotid artery.
Gene therapy 2000;7(17):1499-504.
2000: Laukkanen M O; Lehtolainen P; Turunen P; Aittomäki S; Oikari P; Marklund S L; Ylä-Herttuala S
Rabbit extracellular superoxide dismutase: expression and effect on LDL oxidation.
Gene 2000;254(1-2):173-9.
2000: Sandmair A M; Turunen M; Tyynelä K; Loimas S; Vainio P; Vanninen R; Vapalahti M; Bjerkvig R; Jänne J; Ylä-Herttuala S
Herpes simplex virus thymidine kinase gene therapy in experimental rat BT4C glioma model: effect of the percentage of thymidine kinase-positive glioma cells on treatment effect, survival time, and tissue reactions.
Cancer gene therapy 2000;7(3):413-21.
2000: Laukkanen J; Lehtolainen P; Gough P J; Greaves D R; Gordon S; Ylä-Herttuala S
Adenovirus-mediated gene transfer of a secreted form of human macrophage scavenger receptor inhibits modified low-density lipoprotein degradation and foam-cell formation in macrophages.
Circulation 2000;101(10):1091-6.
2000: Pakkanen T M; Laitinen M; Hippeläinen M; Hiltunen M O; Alhava E; Ylä-Herttuala S
Periadventitial lacZ gene transfer to pig carotid arteries using a biodegradable collagen collar or a wrap of collagen sheet with adenoviruses and plasmid-liposome complexes.
The journal of gene medicine 2000;2(1):52-60.
2000: Laitinen M; Hartikainen J; Hiltunen M O; Eränen J; Kiviniemi M; Närvänen O; Mäkinen K; Manninen H; Syvänne M; Martin J F; Laakso M; Ylä-Herttuala S
Catheter-mediated vascular endothelial growth factor gene transfer to human coronary arteries after angioplasty.
Human gene therapy 2000;11(2):263-70.
2000: Ylä-Herttuala S; Martin J F
Cardiovascular gene therapy.
Lancet 2000;355(9199):213-22.
2000: Erkkilä A T; Närvänen O; Lehto S; Uusitupa M I; Ylä-Herttuala S
Autoantibodies against oxidized low-density lipoprotein and cardiolipin in patients with coronary heart disease.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(1):204-9.
2000: Lehtolainen P; Takeya M; Ylä-Herttuala S
Retrovirus-mediated, stable scavenger-receptor gene transfer leads to functional endocytotic receptor expression, foam cell formation, and increased susceptibility to apoptosis in rabbit aortic smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(1):52-60.
2000: Visted T; Thorsen J; Thorsen F; Read T A; Ulvestad E; Engebraaten O; Sorensen D; Ylä-Herttuala S; Tyynela K; Rucklidge G; Edvardsen K; Bjerkvig R; Lund-Johansen M
lacZ-neoR transfected glioma cells in syngeneic rats: growth pattern and characterization of the host immune response against cells transplanted inside and outside the CNS.
International journal of cancer. Journal international du cancer 2000;85(2):228-35.
2000: Mäkinen K; Loimas S; Kosma V M; Wahlfors J; Ylä-Herttuala S; Alhava E; Jänne J
Adenovirus-mediated gene transfer into an experimental pancreatic tumour.
Annales chirurgiae et gynaecologiae 2000;89(2):99-103.
2000: Sandmair A M; Vapalahti M; Ylä-Herttuala S
Adenoviruses as gene delivery vectors.
Advances in experimental medicine and biology 2000;465():423-9.
2000: Sandmair A M; Vapalahti M; Ylä-Herttuala S
Adenovirus-mediated herpes simplex thymidine kinase gene therapy for brain tumors.
Advances in experimental medicine and biology 2000;465():163-70.
2000: Hiltunen M O; Turunen M P; Laitinen M; Ylä-Herttuala S
Insights into the molecular pathogenesis of atherosclerosis and therapeutic strategies using gene transfer.
Vascular medicine (London, England) 2000;5(1):41-8.
1999: Hiltunen M O; Niemi M; Ylä-Herttuala S
Functional genomics and DNA array techniques in atherosclerosis research.
Current opinion in lipidology 1999;10(6):515-9.
1999: Häkkinen T; Luoma J S; Hiltunen M O; Macphee C H; Milliner K J; Patel L; Rice S Q; Tew D G; Karkola K; Ylä-Herttuala S
Lipoprotein-associated phospholipase A(2), platelet-activating factor acetylhydrolase, is expressed by macrophages in human and rabbit atherosclerotic lesions.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(12):2909-17.
1999: Hakumäki J M; Poptani H; Sandmair A M; Ylä-Herttuala S; Kauppinen R A
1H MRS detects polyunsaturated fatty acid accumulation during gene therapy of glioma: implications for the in vivo detection of apoptosis.
Nature medicine 1999;5(11):1323-7.
1999: Pakkanen T M; Laitinen M; Hippeläinen M; Hiltunen M O; Lehtolainen P; Leppänen P; Luoma J S; Alhava E; Ylä-Herttuala S
Improved gene transfer efficiency in liver with vesicular stomatitis virus G-protein pseudotyped retrovirus after partial liver resection and thymidine kinase-ganciclovir pre-treatment.
Pharmacological research : the official journal of the Italian Pharmacological Society 1999;40(5):451-7.
1999: Mäkimattila S; Luoma J S; Ylä-Herttuala S; Bergholm R; Utriainen T; Virkamäki A; Mäntysaari M; Summanen P; Yki-Järvinen H
Autoantibodies against oxidized LDL and endothelium-dependent vasodilation in insulin-dependent diabetes mellitus.
Atherosclerosis 1999;147(1):115-22.
1999: Pakkanen T; Ylä-Herttuala S
Gene therapy for atherosclerosis and atherosclerosis-related diseases.
Current atherosclerosis reports 1999;1(2):123-30.
1999: Laukkanen M O; Mannermaa S; Hiltunen M O; Aittomäki S; Airenne K; Jänne J; Ylä-Herttuala S
Local hypomethylation in atherosclerosis found in rabbit ec-sod gene.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(9):2171-8.
1999: Luoma J S; Ylä-Herttuala S
Expression of inducible nitric oxide synthase in macrophages and smooth muscle cells in various types of human atherosclerotic lesions.
Virchows Archiv : an international journal of pathology 1999;434(6):561-8.
1999: Agrawal R S; Karhu K; Laukkanen J; Kirkinen P; Ylä-Herttuala S; Agrawal Y P
Complement and anti-alpha-galactosyl natural antibody-mediated inactivation of murine retrovirus occurs in adult serum but not in umbilical cord serum.
Gene therapy 1999;6(1):146-8.
1999: Pakkanen T M; Laitinen M; Hippeläinen M; Kallionpää H; Lehtolainen P; Leppänen P; Luoma J S; Tarvainen R; Alhava E; Ylä-Herttuala S
Enhanced plasma cholesterol lowering effect of retrovirus-mediated LDL receptor gene transfer to WHHL rabbit liver after improved surgical technique and stimulation of hepatocyte proliferation by combined partial liver resection and thymidine kinase--ganciclovir treatment.
Gene therapy 1999;6(1):34-41.
1999: Turunen M P; Hiltunen M O; Ruponen M; Virkamäki L; Szoka F C; Urtti A; Ylä-Herttuala S
Efficient adventitial gene delivery to rabbit carotid artery with cationic polymer-plasmid complexes.
Gene therapy 1999;6(1):6-11.
1999: Ruponen M; Ylä-Herttuala S; Urtti A
Interactions of polymeric and liposomal gene delivery systems with extracellular glycosaminoglycans: physicochemical and transfection studies.
Biochimica et biophysica acta 1999;1415(2):331-41.
1999: Lehtimäki T; Lehtinen S; Solakivi T; Nikkilä M; Jaakkola O; Jokela H; Ylä-Herttuala S; Luoma J S; Koivula T; Nikkari T
Autoantibodies against oxidized low density lipoprotein in patients with angiographically verified coronary artery disease.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(1):23-7.
1999: Viita H; Sen C K; Roy S; Siljamäki T; Nikkari T; Ylä-Herttuala S
High expression of human 15-lipoxygenase induces NF-kappaB-mediated expression of vascular cell adhesion molecule 1, intercellular adhesion molecule 1, and T-cell adhesion on human endothelial cells.
Antioxidants & redox signaling 1999;1(1):83-96.
1999: Sandmair A M; Loimas S; Poptani H; Vainio P; Vanninen R; Turunen M; Tyynelä K; Vapalahti M; Ylä-Herttuala S
Low efficacy of gene therapy for rat BT4C malignant glioma using intra-tumoural transduction with thymidine kinase retrovirus packaging cell injections and ganciclovir treatment.
Acta neurochirurgica 1999;141(8):867-72; discussion 872-3.
1999: Viita H; Närvänen O; Ylä-Herttuala S
Different apolipoprotein B breakdown patterns in models of oxidized low density lipoprotein.
Life sciences 1999;65(8):783-93.
1999: Ylitalo R; Jaakkola O; Lehtolainen P; Ylä-Herttuala S
Metabolism of modified LDL and foam cell formation in murine macrophage-like RAW 264 cells.
Life sciences 1999;64(21):1955-65.
1998: Laitinen M; Ylä-Herttuala S
Vascular gene transfer for the treatment of restenosis and atherosclerosis.
Current opinion in lipidology 1998;9(5):465-9.
1998: Hakumäki J M; Poptani H; Puumalainen A M; Loimas S; Paljärvi L A; Ylä-Herttuala S; Kauppinen R A
Quantitative 1H nuclear magnetic resonance diffusion spectroscopy of BT4C rat glioma during thymidine kinase-mediated gene therapy in vivo: identification of apoptotic response.
Cancer research 1998;58(17):3791-9.
1998: Ylä-Herttuala S
Is oxidized low-density lipoprotein present in vivo?
Current opinion in lipidology 1998;9(4):337-44.
1998: Puumalainen A M; Vapalahti M; Agrawal R S; Kossila M; Laukkanen J; Lehtolainen P; Viita H; Paljärvi L; Vanninen R; Ylä-Herttuala S
Beta-galactosidase gene transfer to human malignant glioma in vivo using replication-deficient retroviruses and adenoviruses.
Human gene therapy 1998;9(12):1769-74.
1998: Manninen H I; Vanninen R L; Laitinen M; Räsänen H; Vainio P; Luoma J S; Pakkanen T; Tulla H; Ylä-Herttuala S
Intravascular ultrasound and magnetic resonance imaging in the assessment of atherosclerotic lesions in rabbit aorta. Correlation to histopathologic findings.
Investigative radiology 1998;33(8):464-71.
1998: Laitinen M; Mäkinen K; Manninen H; Matsi P; Kossila M; Agrawal R S; Pakkanen T; Luoma J S; Viita H; Hartikainen J; Alhava E; Laakso M; Ylä-Herttuala S
Adenovirus-mediated gene transfer to lower limb artery of patients with chronic critical leg ischemia.
Human gene therapy 1998;9(10):1481-6.
1998: Ahotupa M; Marniemi J; Lehtimäki T; Talvinen K; Raitakari O T; Vasankari T; Viikari J; Luoma J; Ylä-Herttuala S
Baseline diene conjugation in LDL lipids as a direct measure of in vivo LDL oxidation.
Clinical biochemistry 1998;31(4):257-61.
1998: Häkkinen T; Ylä-Herttuala S
Artifact occurring during combined in situ hybridization and immunocytochemistry analysis because of positive chemography.
BioTechniques 1998;24(5):730-2.
1998: Laitinen M; Ylä-Herttuala S
Adventitial gene transfer to arterial wall.
Pharmacological research : the official journal of the Italian Pharmacological Society 1998;37(4):251-4.
1998: Poptani H; Puumalainen A M; Gröhn O H; Loimas S; Kainulainen R; Ylä-Herttuala S; Kauppinen R A
Monitoring thymidine kinase and ganciclovir-induced changes in rat malignant glioma in vivo by nuclear magnetic resonance imaging.
Cancer gene therapy 1998;5(2):101-9.
1998: Hiltunen T P; Luoma J S; Nikkari T; Ylä-Herttuala S
Expression of LDL receptor, VLDL receptor, LDL receptor-related protein, and scavenger receptor in rabbit atherosclerotic lesions: marked induction of scavenger receptor and VLDL receptor expression during lesion development.
Circulation 1998;97(11):1079-86.
1998: Luoma J S; Strålin P; Marklund S L; Hiltunen T P; Särkioja T; Ylä-Herttuala S
Expression of extracellular SOD and iNOS in macrophages and smooth muscle cells in human and rabbit atherosclerotic lesions: colocalization with epitopes characteristic of oxidized LDL and peroxynitrite-modified proteins.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(2):157-67.
1998: Leppänen P; Luoma J S; Hofker M H; Havekes L M; Ylä-Herttuala S
Characterization of atherosclerotic lesions in apo E3-leiden transgenic mice.
Atherosclerosis 1998;136(1):147-52.
1998: Puumalainen A M; Vapalahti M; Ylä-Herttuala S
Gene therapy for malignant glioma patients.
Advances in experimental medicine and biology 1998;451():505-9.
1998: Ylitalo R; Mönkkönen J; Ylä-Herttuala S
Effects of liposome-encapsulated bisphosphonates on acetylated LDL metabolism, lipid accumulation and viability of phagocyting cells.
Life sciences 1998;62(5):413-22.
1997: Laitinen M; Zachary I; Breier G; Pakkanen T; Häkkinen T; Luoma J; Abedi H; Risau W; Soma M; Laakso M; Martin J F; Ylä-Herttuala S
VEGF gene transfer reduces intimal thickening via increased production of nitric oxide in carotid arteries.
Human gene therapy 1997;8(15):1737-44.
1997: Laitinen M; Pakkanen T; Donetti E; Baetta R; Luoma J; Lehtolainen P; Viita H; Agrawal R; Miyanohara A; Friedmann T; Risau W; Martin J F; Soma M; Ylä-Herttuala S
Gene transfer into the carotid artery using an adventitial collar: comparison of the effectiveness of the plasmid-liposome complexes, retroviruses, pseudotyped retroviruses, and adenoviruses.
Human gene therapy 1997;8(14):1645-50.
1997: Raitakari O T; Pitkänen O P; Lehtimäki T; Lahdenperä S; Iida H; Ylä-Herttuala S; Luoma J; Mattila K; Nikkari T; Taskinen M R; Viikari J S; Knuuti J
In vivo low density lipoprotein oxidation relates to coronary reactivity in young men.
Journal of the American College of Cardiology 1997;30(1):97-102.
1997: Thorsen F; Visted T; Lehtolainen P; Ylä-Herttuala S; Bjerkvig R
Release of replication-deficient retroviruses from a packaging cell line: interaction with glioma tumor spheroids in vitro.
International journal of cancer. Journal international du cancer 1997;71(5):874-80.
1997: Ylä-Herttuala S
Vascular gene transfer.
Current opinion in lipidology 1997;8(2):72-6.
1996: Ylä-Herttuala S
Expression of lipoprotein receptors and related molecules in atherosclerotic lesions.
Current opinion in lipidology 1996;7(5):292-7.
1996: Ylä-Herttuala S; Luoma J; Kallionpää H; Laukkanen M; Lehtolainen P; Viita H
Pathogenesis of atherosclerosis.
Maturitas 1996;23 Suppl():S47-9.
1995: Hiltunen T; Luoma J; Nikkari T; Ylä-Herttuala S
Induction of 15-lipoxygenase mRNA and protein in early atherosclerotic lesions.
Circulation 1995;92(11):3297-303.
1995: Ylä-Herttuala S; Luoma J; Viita H; Hiltunen T; Sisto T; Nikkari T
Transfer of 15-lipoxygenase gene into rabbit iliac arteries results in the appearance of oxidation-specific lipid-protein adducts characteristic of oxidized low density lipoprotein.
The Journal of clinical investigation 1995;95(6):2692-8.
1995: Stavri G T; Hong Y; Zachary I C; Breier G; Baskerville P A; Ylä-Herttuala S; Risau W; Martin J F; Erusalimsky J D
Hypoxia and platelet-derived growth factor-BB synergistically upregulate the expression of vascular endothelial growth factor in vascular smooth muscle cells.
FEBS letters 1995;358(3):311-5.
1995: Nikkari T; Malo-Ranta U; Hiltunen T; Jaakkola O; Ylä-Herttuala S
Monitoring of lipoprotein oxidation by gas chromatographic analysis of hydroxy fatty acids.
Journal of lipid research 1995;36(1):200-7.
1994: Hiltunen T; Raja-Honkala M; Nikkari T; Ylä-Herttuala S
A PCR artifact under low-stringency conditions due to amplification by only one primer.
BioTechniques 1994;17(2):240-2.
1994: Ylitalo R; Oksala O; Ylä-Herttuala S; Ylitalo P
Effects of clodronate (dichloromethylene bisphosphonate) on the development of experimental atherosclerosis in rabbits.
The Journal of laboratory and clinical medicine 1994;123(5):769-76.
1994: Luoma J; Hiltunen T; Särkioja T; Moestrup S K; Gliemann J; Kodama T; Nikkari T; Ylä-Herttuala S
Expression of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein and scavenger receptor in human atherosclerotic lesions.
The Journal of clinical investigation 1994;93(5):2014-21.
1994: Malo-Ranta U; Ylä-Herttuala S; Metsä-Ketelä T; Jaakkola O; Moilanen E; Vuorinen P; Nikkari T
Nitric oxide donor GEA 3162 inhibits endothelial cell-mediated oxidation of low density lipoprotein.
FEBS letters 1994;337(2):179-83.
1990: Sisto T; Ylä-Herttuala S; Luoma J; Riekkinen H; Nikkari T
Biochemical composition of human internal mammary artery and saphenous vein.
Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter 1990;11(3):418-22.
1989: Jaakkola O; Ylä-Herttuala S; Särkioja T; Nikkari T
Macrophage foam cells from human aortic fatty streaks take up beta-VLDL and acetylated LDL in primary culture.
Atherosclerosis 1989;79(2-3):173-82.
1989: Jaakkola O; Solakivi T; Ylä-Herttuala S; Nikkari T
Receptor-mediated binding and degradation of subfractions of human plasma low-density lipoprotein by cultured fibroblasts.
Biochimica et biophysica acta 1989;1005(2):118-22.
1989: Ylä-Herttuala S; Luoma J; Nikkari T; Kivimäki T
Down's syndrome and atherosclerosis.
Atherosclerosis 1989;76(2-3):269-72.
1988: Ylä-Herttuala S; Pesonen E; Kaprio E; Rapola J; Soveri T; Viikari J; Savilahti E; Oksanen H; Nikkari T
Effect of repeated endotoxin treatment and hypercholesterolemia on preatherosclerotic lesions in weaned pigs. Part II. Lipid and glycosaminoglycan analysis of intima and inner media.
Atherosclerosis 1988;72(2-3):173-81.
1988: Ylä-Herttuala S; Jaakkola O; Ehnholm C; Tikkanen M J; Solakivi T; Särkioja T; Nikkari T
Characterization of two lipoproteins containing apolipoproteins B and E from lesion-free human aortic intima.
Journal of lipid research 1988;29(5):563-72.
1987: Pesonen E; Kaprio E; Rapola J; Soveri T; Viikari J; Savilahti E; Ylä-Herttuala S; Oksanen H
Effect of repeated endotoxin treatment and hypercholesterolemia on preatherosclerotic lesions in weaned pigs. Part 1. Scanning and transmission electron microscopic study.
Atherosclerosis 1987;65(1-2):89-98.
1986: Ylä-Herttuala S; Jaakkola O; Solakivi T; Kuivaniemi H; Nikkari T
The effect of proteoglycans, collagen and lysyl oxidase on the metabolism of low density lipoprotein by macrophages.
Atherosclerosis 1986;62(1):73-80.

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