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Sue Yocum

Research Profile

Chemicals & Drugs

Concepts & Ideas

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Publications

TOP 3
Ralph P Robinson; Leonard Buckbinder; Amber I Haugeto; Patricia A McNiff; Michele L Millham; Matthew R Reese; Jean F Schaefer; Yuriy A Abramov; Jon Bordner; Yves A Chantigny; Edward F Kleinman; Ellen R Laird; Bradley P Morgan; John C Murray; Eben D Salter; Matthew D Wessel; Sue A Yocum
Octahydrophenanthrene-2,7-diol analogues as dissociated glucocorticoid receptor agonists: discovery and lead exploration.
Kevin D Freeman-Cook; Lawrence A Reiter; Mark C Noe; Amy S Antipas; dennis danley; Kaushik Datta; James T Downs; Shane Eisenbeis; James D Eskra; David J Garmene; Elaine M Greer; Richard J Griffiths; Roberto Guzman; Joel R Hardink; Fouad Janat; Christopher S Jones; Gary J Martinelli; Peter G Mitchell; Ellen R Laird; Jennifer L Liras; Lori L Lopresti-Morrow; Jayvardhan Pandit; Usa D Reilly; Donald Robertson; Marcie L Vaughn-Bowser; Lilli A Wolf-Gouviea; Sue A Yocum
Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13.
Lawrence A Reiter; Kevin D Freeman-Cook; Christopher S Jones; Gary J Martinelli; Amy S Antipas; Martin A Berliner; Kaushik Datta; James T Downs; James D Eskra; Michael D Forman; Elaine M Greer; Roberto Guzman; Joel R Hardink; Fouad Janat; Nandell F Keene; Ellen R Laird; Jennifer L Liras; Lori L Lopresti-Morrow; Peter G Mitchell; Jayvardhan Pandit; Donald Robertson; Diana Sperger; Marcie L Vaughn-Bowser; Darra M Waller; Sue A Yocum
Potent, selective pyrimidinetrione-based inhibitors of MMP-13.

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All Publications

2009: Ralph P Robinson; Leonard Buckbinder; Amber I Haugeto; Patricia A McNiff; Michele L Millham; Matthew R Reese; Jean F Schaefer; Yuriy A Abramov; Jon Bordner; Yves A Chantigny; Edward F Kleinman; Ellen R Laird; Bradley P Morgan; John C Murray; Eben D Salter; Matthew D Wessel; Sue A Yocum
Octahydrophenanthrene-2,7-diol analogues as dissociated glucocorticoid receptor agonists: discovery and lead exploration.
Journal of medicinal chemistry 2009;52(6):1731-43.
2007: Kevin D Freeman-Cook; Lawrence A Reiter; Mark C Noe; Amy S Antipas; dennis danley; Kaushik Datta; James T Downs; Shane Eisenbeis; James D Eskra; David J Garmene; Elaine M Greer; Richard J Griffiths; Roberto Guzman; Joel R Hardink; Fouad Janat; Christopher S Jones; Gary J Martinelli; Peter G Mitchell; Ellen R Laird; Jennifer L Liras; Lori L Lopresti-Morrow; Jayvardhan Pandit; Usa D Reilly; Donald Robertson; Marcie L Vaughn-Bowser; Lilli A Wolf-Gouviea; Sue A Yocum
Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13.
Bioorganic & medicinal chemistry letters 2007;17(23):6529-34.
2006: Lawrence A Reiter; Kevin D Freeman-Cook; Christopher S Jones; Gary J Martinelli; Amy S Antipas; Martin A Berliner; Kaushik Datta; James T Downs; James D Eskra; Michael D Forman; Elaine M Greer; Roberto Guzman; Joel R Hardink; Fouad Janat; Nandell F Keene; Ellen R Laird; Jennifer L Liras; Lori L Lopresti-Morrow; Peter G Mitchell; Jayvardhan Pandit; Donald Robertson; Diana Sperger; Marcie L Vaughn-Bowser; Darra M Waller; Sue A Yocum
Potent, selective pyrimidinetrione-based inhibitors of MMP-13.
Bioorganic & medicinal chemistry letters 2006;16(22):5822-6.
2005: Mark C Noe; Vijayalakshmi Natarajan; Sheri L Snow; Lilli A Wolf-Gouveia; Peter G Mitchell; Lori L Lopresti-Morrow; Lisa M Reeves; Sue A Yocum; Ivan G Otterness; Marcia A Bliven; Thomas J Carty; John T Barberia; Francis J Sweeney; Jennifer L Liras; Marcie Vaughn
Discovery of 3-OH-3-methylpipecolic hydroxamates: potent orally active inhibitors of aggrecanase and MMP-13.
Bioorganic & medicinal chemistry letters 2005;15(14):3385-8.
2005: Mark C Noe; Vijayalakshmi Natarajan; Sheri L Snow; Peter G Mitchell; Lori L Lopresti-Morrow; Lisa M Reeves; Sue A Yocum; Thomas J Carty; John A Barberia; Francis J Sweeney; Jennifer L Liras; Marcie Vaughn; Joel R Hardink; Joel M Hawkins; Christopher Tokar
Discovery of 3,3-dimethyl-5-hydroxypipecolic hydroxamate-based inhibitors of aggrecanase and MMP-13.
Bioorganic & medicinal chemistry letters 2005;15(11):2808-11.
2005: Julian A Blagg; Mark C Noe; Lilli A Wolf-Gouveia; Lawrence A Reiter; Ellen R Laird; Shang-Poa P Chang; dennis danley; James T Downs; Nancy C Elliott; James D Eskra; Richard J Griffiths; Joel R Hardink; Amber I Haugeto; Christopher S Jones; Jennifer L Liras; Lori L Lopresti-Morrow; Peter G Mitchell; Jayvardhan Pandit; Ralph P Robinson; Chakrapani Subramanyam; Marcie L Vaughn-Bowser; Sue A Yocum
Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14.
Bioorganic & medicinal chemistry letters 2005;15(7):1807-10.
2004: Mark C Noe; Sheri L Snow; Lilli A Wolf-Gouveia; Peter G Mitchell; Lori L Lopresti-Morrow; Lisa M Reeves; Sue A Yocum; Jennifer L Liras; Marcie Vaughn
3-Hydroxy-4-arylsulfonyltetrahydropyranyl-3-hydroxamic acids are novel inhibitors of MMP-13 and aggrecanase.
Bioorganic & medicinal chemistry letters 2004;14(18):4727-30.
2004: Lawrence A Reiter; Ralph P Robinson; Kim F McClure; Christopher S Jones; Matthew R Reese; Peter G Mitchell; Ivan G Otterness; Marcia L Bliven; Jennifer L Liras; Santo R Cortina; Kathleen M Donahue; James D Eskra; Richard J Griffiths; Mary E Lame; Arturo Lopez-Anaya; Gary J Martinelli; Shunda M McGahee; Sue A Yocum; Lori L Lopresti-Morrow; Lisa M Tobiassen; Marcie L Vaughn-Bowser
Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1.
Bioorganic & medicinal chemistry letters 2004;14(13):3389-95.
2003: Lawrence A Reiter; Peter G Mitchell; Gary J Martinelli; Lori L Lopresti-Morrow; Sue A Yocum; James D Eskra
Phosphinic acid-based MMP-13 inhibitors that spare MMP-1 and MMP-3.
Bioorganic & medicinal chemistry letters 2003;13(14):2331-6.
2001: Ralph P Robinson; Ellen R Laird; Kathleen M Donahue; Lori L Lopresti-Morrow; Peter G Mitchell; Matthew R Reese; Lisa M Reeves; A I Rouch; Ethan J Stam; Sue A Yocum
Design and synthesis of 2-oxo-imidazolidine-4-carboxylic acid hydroxyamides as potent matrix metalloproteinase-13 inhibitors.
Bioorganic & medicinal chemistry letters 2001;11(9):1211-3.
2000: Ralph P Robinson; Ellen R Laird; James F Blake; Jon Bordner; Kathleen M Donahue; Lori L Lopresti-Morrow; Peter G Mitchell; Matthew R Reese; Lisa M Reeves; Ethan J Stam; Sue A Yocum
Structure-based design and synthesis of a potent matrix metalloproteinase-13 inhibitor based on a pyrrolidinone scaffold.
Journal of medicinal chemistry 2000;43(12):2293-6.
1999: Sue A Yocum; Lori L Lopresti-Morrow; Lisa M Reeves; Peter G Mitchell
MMP-13 and MMP-1 expression in tissues of normal articular joints.
Annals of the New York Academy of Sciences 1999;878():583-6.
1999: Lawrence A Reiter; J P Rizzi; Jayvardhan Pandit; M J Lasut; S M McGahee; V D Parikh; James F Blake; dennis danley; Ellen R Laird; Arturo Lopez-Anaya; Lori L Lopresti-Morrow; Mahmoud N Mansour; Gary J Martinelli; Peter G Mitchell; B S Owens; Thomas A Pauly; Lisa M Reeves; Gayle K Schulte; Sue A Yocum
Inhibition of MMP-1 and MMP-13 with phosphinic acids that exploit binding in the S2 pocket.
Bioorganic & medicinal chemistry letters 1999;9(2):127-32.
1996: Peter G Mitchell; H A Magna; Lisa M Reeves; Lori L Lopresti-Morrow; Sue A Yocum; P J Rosner; Kieran F Geoghegan; J E Hambor
Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage.
The Journal of clinical investigation 1996;97(3):761-8.
1995: Sue A Yocum; Lori L Lopresti-Morrow; C A Gabel; Anthony J Milici; Peter G Mitchell
Bafilomycin A1 inhibits IL-1-stimulated proteoglycan degradation by chondrocytes without affecting stromelysin synthesis.
Archives of biochemistry and biophysics 1995;316(2):827-35.
1994: Peter G Mitchell; Lori L Lopresti-Morrow; Sue A Yocum; F J Sweeney; Lawrence A Reiter
Inhibition of interleukin-1-stimulated collagen degradation in cartilage explants.
Annals of the New York Academy of Sciences 1994;732():395-7.