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Kohei Yokoyama
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28
Gelb, Michael
21
Van Voorhis, Wesley
19
Buckner, Frederick
8
Eastman, Richard
8
Chakrabarti, Debopam
6
Verlinde, Christophe
6
Rivas, Kasey
6
Hamilton, Andrew
5
Sebti, Said
4
Hornéy, Carrie
4
Hucke, Oliver
4
Nallan, Laxman
4
Ohkanda, Junko
4
Pendyala, Prakash Rao
3
Lockman, Jeffrey
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Geonetwork of Kohei Yokoyama (preview)
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All Publications
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2009: Torres-Santos Eduardo Caio; Sampaio-Santos Maria Isabel; Buckner Frederick S; Yokoyama Kohei; Gelb Michael; Urbina Julio A; Rossi-Bergmann Bartira
Altered sterol profile induced in Leishmania amazonensis by a natural dihydroxymethoxylated chalcone.
The Journal of antimicrobial chemotherapy 2009;63(3):469-72.
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2008: Olepu Srinivas; Suryadevara Praveen Kumar; Rivas Kasey; Yokoyama Kohei; Verlinde Christophe L M J; Chakrabarti Debopam; Van Voorhis Wesley C; Gelb Michael H
2-Oxo-tetrahydro-1,8-naphthyridines as selective inhibitors of malarial protein farnesyltransferase and as anti-malarials.
Bioorganic & medicinal chemistry letters 2008;18(2):494-7.
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2008: Yokoyama Kohei; Gillespie John R; Van Voorhis Wesley C; Buckner Frederick S; Gelb Michael H
Protein geranylgeranyltransferase-I of Trypanosoma cruzi.
Molecular and biochemical parasitology 2008;157(1):32-43.
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2007: Van Voorhis Wesley C; Rivas Kasey L; Bendale Pravin; Nallan Laxman; Hornéy Carolyn; Barrett Lynn K; Bauer Kevin D; Smart Brian P; Ankala Sudha; Hucke Oliver; Verlinde Christophe L M J; Chakrabarti Debopam; Strickland Corey; Yokoyama Kohei; Buckner Frederick S; Hamilton Andrew D; Williams David K; Lombardo Louis J; Floyd David; Gelb Michael H
Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase.
Antimicrobial agents and chemotherapy 2007;51(10):3659-71.
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2007: Bendale Pravin; Olepu Srinivas; Suryadevara Praveen Kumar; Bulbule Vivek; Rivas Kasey; Nallan Laxman; Smart Brian; Yokoyama Kohei; Ankala Sudha; Pendyala Prakash Rao; Floyd David; Lombardo Louis J; Williams David K; Buckner Frederick S; Chakrabarti Debopam; Verlinde Christophe L M J; Van Voorhis Wesley C; Gelb Michael H
Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials.
Journal of medicinal chemistry 2007;50(19):4585-605.
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2007: Gillespie John R; Yokoyama Kohei; Lu Karen; Eastman Richard T; Bollinger James G; Van Voorhis Wesley C; Gelb Michael H; Buckner Frederick S
C-terminal proteolysis of prenylated proteins in trypanosomatids and RNA interference of enzymes required for the post-translational processing pathway of farnesylated proteins.
Molecular and biochemical parasitology 2007;153(2):115-24.
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2007: Eastman Richard T; White John; Hucke Oliver; Yokoyama Kohei; Verlinde Christophe L M J; Hast Michael A; Beese Lorena S; Gelb Michael H; Rathod Pradipsinh K; Van Voorhis Wesley C
Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase.
Molecular and biochemical parasitology 2007;152(1):66-71.
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2006: Glenn Matthew P; Chang Sung-Youn; Hornéy Carrie; Rivas Kasey; Yokoyama Kohei; Pusateri Erin E; Fletcher Steven; Cummings Christopher G; Buckner Frederick S; Pendyala Prakash R; Chakrabarti Debopam; Sebti Saïd M; Gelb Michael; Van Voorhis Wesley C; Hamilton Andrew D
Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites.
Journal of medicinal chemistry 2006;49(19):5710-27.
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2006: Eastman Richard T; Buckner Frederick S; Yokoyama Kohei; Gelb Michael H; Van Voorhis Wesley C
Thematic review series: lipid posttranslational modifications. Fighting parasitic disease by blocking protein farnesylation.
Journal of lipid research 2006;47(2):233-40.
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2005: Buckner Frederick S; Eastman Richard T; Yokoyama Kohei; Gelb Michael H; Van Voorhis Wesley C
Protein farnesyl transferase inhibitors for the treatment of malaria and African trypanosomiasis.
Current opinion in investigational drugs (London, England : 2000) 2005;6(8):791-7.
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2005: Glenn Matthew P; Chang Sung-Youn; Hucke Oliver; Verlinde Christophe L M J; Rivas Kasey; Hornéy Carrie; Yokoyama Kohei; Buckner Frederick S; Pendyala Prakash R; Chakrabarti Debopam; Gelb Michael; Van Voorhis Wesley C; Sebti Saïd M; Hamilton Andrew D
Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites.
Angewandte Chemie (International ed. in English) 2005;44(31):4903-6.
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2005: Nallan Laxman; Bauer Kevin D; Bendale Pravin; Rivas Kasey; Yokoyama Kohei; Hornéy Carolyn P; Pendyala Prakash Rao; Floyd David; Lombardo Louis J; Williams David K; Hamilton Andrew; Sebti Said; Windsor William T; Weber Patricia C; Buckner Frederick S; Chakrabarti Debopam; Gelb Michael H; Van Voorhis Wesley C
Protein farnesyltransferase inhibitors exhibit potent antimalarial activity.
Journal of medicinal chemistry 2005;48(11):3704-13.
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2005: Eastman Richard T; White John; Hucke Oliver; Bauer Kevin; Yokoyama Kohei; Nallan Laxman; Chakrabarti Debopam; Verlinde Christophe L M J; Gelb Michael H; Rathod Pradipsinh K; Van Voorhis Wesley C
Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum.
The Journal of biological chemistry 2005;280(14):13554-9.
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2004: Carrico Dora; Ohkanda Junko; Kendrick Howard; Yokoyama Kohei; Blaskovich Michelle A; Bucher Cynthia J; Buckner Frederick S; Van Voorhis Wesley C; Chakrabarti Debopam; Croft Simon L; Gelb Michael H; Sebti Saïd M; Hamilton Andrew D
In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability.
Bioorganic & medicinal chemistry 2004;12(24):6517-26.
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2004: Ohkanda Junko; Buckner Frederick S; Lockman Jeffrey W; Yokoyama Kohei; Carrico Dora; Eastman Richard; de Luca-Fradley Kate; Davies Wendy; Croft Simon L; Van Voorhis Wesley C; Gelb Michael H; Sebti Saïd M; Hamilton Andrew D
Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents.
Journal of medicinal chemistry 2004;47(2):432-45.
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2003: Buckner Frederick; Yokoyama Kohei; Lockman Jeffrey; Aikenhead Kendra; Ohkanda Junko; Sadilek Martin; Sebti Said; Van Voorhis Wesley; Hamilton Andrew; Gelb Michael H
A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):15149-53.
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2003: Gelb Michael H; Van Voorhis Wesley C; Buckner Frederick S; Yokoyama Kohei; Eastman Richard; Carpenter Elisabeth P; Panethymitaki Chrysoula; Brown Katherine A; Smith Deborah F
Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics.
Molecular and biochemical parasitology 2003;126(2):155-63.
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2002: Buckner Frederick S; Kateete David P; Lubega George W; Van Voorhis Wesley C; Yokoyama Kohei
Trypanosoma brucei prenylated-protein carboxyl methyltransferase prefers farnesylated substrates.
The Biochemical journal 2002;367(Pt 3):809-16.
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2002: Buckner Frederick S; Eastman Richard T; Nepomuceno-Silva José L; Speelmon Emily C; Myler Peter J; Van Voorhis Wesley C; Yokoyama Kohei
Cloning, heterologous expression, and substrate specificities of protein farnesyltransferases from Trypanosoma cruzi and Leishmania major.
Molecular and biochemical parasitology 2002;122(2):181-8.
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2001: Nepomuceno-Silva J L; Yokoyama K; de Mello L D; Mendonca S M; Paixão J C; Baron R; Faye J C; Buckner F S; Van Voorhis W C; Gelb M H; Lopes U G
TcRho1, a farnesylated Rho family homologue from Trypanosoma cruzi: cloning, trans-splicing, and prenylation studies.
The Journal of biological chemistry 2001;276(32):29711-8.
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2001: Ohkanda J; Lockman J W; Yokoyama K; Gelb M H; Croft S L; Kendrick H; Harrell M I; Feagin J E; Blaskovich M A; Sebti S M; Hamilton A D
Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity.
Bioorganic & medicinal chemistry letters 2001;11(6):761-4.
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2000: Whitten M E; Yokoyama K; Schieltz D; Ghomashchi F; Lam D; Yates J R; Palczewski K; Gelb M H
Structural analysis of protein prenyl groups and associated C-terminal modifications.
Methods in enzymology 2000;316():436-51.
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1999: Zhao X; Yokoyama K; Whitten M E; Huang J; Gelb M H; Palczewski K
A novel form of rhodopsin kinase from chicken retina and pineal gland.
FEBS letters 1999;454(1-2):115-21.
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1998: Yokoyama K; Trobridge P; Buckner F S; Van Voorhis W C; Stuart K D; Gelb M H
Protein farnesyltransferase from Trypanosoma brucei. A heterodimer of 61- and 65-kda subunits as a new target for antiparasite therapeutics.
The Journal of biological chemistry 1998;273(41):26497-505.
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1998: Yokoyama K; Trobridge P; Buckner F S; Scholten J; Stuart K D; Van Voorhis W C; Gelb M H
The effects of protein farnesyltransferase inhibitors on trypanosomatids: inhibition of protein farnesylation and cell growth.
Molecular and biochemical parasitology 1998;94(1):87-97.
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1997: Yokoyama K; Lin Y; Stuart K D; Gelb M H
Prenylation of proteins in Trypanosoma brucei.
Molecular and biochemical parasitology 1997;87(1):61-9.
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1995: Yokoyama K; McGeady P; Gelb M H
Mammalian protein geranylgeranyltransferase-I: substrate specificity, kinetic mechanism, metal requirements, and affinity labeling.
Biochemistry 1995;34(4):1344-54.
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1995: Liu L; Jang G F; Farnsworth C C; Yokoyama K; Glomset J A; Gelb M H
Synthetic prenylated peptides: studying prenyl protein-specific endoprotease and other aspects of protein prenylation.
Methods in enzymology 1995;250():189-206.
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1993: Jang G F; Yokoyama K; Gelb M H
A prenylated protein-specific endoprotease in rat liver microsomes that produces a carboxyl-terminal tripeptide.
Biochemistry 1993;32(36):9500-7.
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1993: Yokoyama K; Gelb M H
Purification of a mammalian protein geranylgeranyltransferase. Formation and catalytic properties of an enzyme-geranylgeranyl pyrophosphate complex.
The Journal of biological chemistry 1993;268(6):4055-60.
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1992: Yokoyama K; Goodwin G W; Ghomashchi F; Glomset J; Gelb M H
Protein prenyltransferases.
Biochemical Society transactions 1992;20(2):489-94.
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1991: Yokoyama K; Goodwin G W; Ghomashchi F; Glomset J A; Gelb M H
A protein geranylgeranyltransferase from bovine brain: implications for protein prenylation specificity.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(12):5302-6.
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