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Takako Yokozawa

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Chan Hum Park; Takashi Tanaka; Takako Yokozawa
Anti-diabetic Action of 7-O-Galloyl-d-sedoheptulose, a Polyphenol from Corni Fructus, through Ameliorating Inflammation and Inflammation-Related Oxidative Stress in the Pancreas of Type 2 Diabetics.
Chan Hum Park; Takashi Tanaka; Jeong Sook Noh; Takako Yokozawa
7-O-galloyl-D-sedoheptulose ameliorates renal damage triggered by reactive oxygen species-sensitive pathway of inflammation and apoptosis.
Chan Hum Park; Takashi Tanaka; Sul Lim Lee; Takuya Okamoto; Takako Yokozawa
Rokumi-jio-gan-Containing Prescriptions Attenuate Oxidative Stress, Inflammation, and Apoptosis in the Remnant Kidney.

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All Publications

2013: Chan Hum Park; Takashi Tanaka; Takako Yokozawa
Anti-diabetic Action of 7-O-Galloyl-d-sedoheptulose, a Polyphenol from Corni Fructus, through Ameliorating Inflammation and Inflammation-Related Oxidative Stress in the Pancreas of Type 2 Diabetics.
Biological & pharmaceutical bulletin 2013;36(5):723-32.
2012: Chan Hum Park; Takashi Tanaka; Jeong Sook Noh; Takako Yokozawa
7-O-galloyl-D-sedoheptulose ameliorates renal damage triggered by reactive oxygen species-sensitive pathway of inflammation and apoptosis.
The Journal of pharmacy and pharmacology 2012;64(12):1730-40.
2012: Chan Hum Park; Takashi Tanaka; Sul Lim Lee; Takuya Okamoto; Takako Yokozawa
Rokumi-jio-gan-Containing Prescriptions Attenuate Oxidative Stress, Inflammation, and Apoptosis in the Remnant Kidney.
Evidence-based complementary and alternative medicine : eCAM 2012;2012():587902.
2012: Qi Zhao; Kinzo Matsumoto; Takeshi Miyata; Yimin Niu; Ken Tanaka; Koichi tsuneyama; Takako Yokozawa
Chotosan ameliorates cognitive and emotional deficits in an animal model of type 2 diabetes: possible involvement of cholinergic and VEGF/PDGF mechanisms in the brain.
BMC complementary and alternative medicine 2012;12():188.
2012: Chan Hum Park; Jong Cheol Park; Jeong Sook Noh; Takuya Okamoto; Takako Yokozawa
Evaluation of Effects of Chinese Prescription Kangen-karyu on Diabetes-Induced Alterations such as Oxidative Stress and Apoptosis in the Liver of Type 2 Diabetic db/db Mice.
Evidence-based complementary and alternative medicine : eCAM 2012;2012():143489.
2012: Takako Yokozawa; Jeong Sook Noh; Chan Hum Park
Green Tea Polyphenols for the Protection against Renal Damage Caused by Oxidative Stress.
Evidence-based complementary and alternative medicine : eCAM 2012;2012():845917.
2012: Jeong Sook Noh; Chan Hum Park; Takashi Tanaka; Takako Yokozawa
7-O-galloyl-D-sedoheptulose attenuates oxidative stress-induced diabetic injury via decreasing expression of nuclear factor-κB- and apoptosis-related protein in the liver.
Biological & pharmaceutical bulletin 2012;35(6):950-6.
2012: Chan Hum Park; Jong Cheol Park; Takashi Tanaka; Hyun Young Kim; Takako Yokozawa
Protective Effects of Corni Fructus against Advanced Glycation Endproducts and Radical Scavenging.
Evidence-based complementary and alternative medicine : eCAM 2012;2012():418953.
2012: Takako Yokozawa; Chan Hum Park; Eun Ju Cho; Ji Hyun Kim
Protective Effect of Proanthocyanidin against Diabetic Oxidative Stress.
Evidence-based complementary and alternative medicine : eCAM 2012;2012():623879.
2011: Chan Hum Park; Jong Cheol Park; Naotoshi Shibahara; Takashi Tanaka; Eun Ju Cho; Ji Hyun Kim; Takako Yokozawa
Hepato-protective effects of loganin, iridoid glycoside from Corni Fructus, against hyperglycemia-activated signaling pathway in liver of type 2 diabetic db/db mice.
Toxicology 2011;290(1):14-21.
2011: Jeong Sook Noh; Chan Hum Park; Takako Yokozawa
Treatment with oligonol, a low-molecular polyphenol derived from lychee fruit, attenuates diabetes-induced hepatic damage through regulation of oxidative stress and lipid metabolism.
The British journal of nutrition 2011;106(7):1013-22.
2011: K Ienaga; Takako Yokozawa
Creatinine and HMH (5-hydroxy-1-methylhydantoin, NZ-419) as intrinsic hydroxyl radical scavengers.
Drug discoveries & therapeutics 2011;5(4):162-75.
2011: Takuya Okamoto; Chan Hum Park; Jeong Sook Noh; Kazuo Toriizuka; Yasuo Sei; Jong Cheol Park; Takako Yokozawa
Hepato-/reno-protective activity of Chinese prescription Kangen-karyu through inhibition of AGE formation and fibrosis-related protein expression in type 2 diabetes.
The Journal of pharmacy and pharmacology 2011;63(7):952-9.
2011: Takako Yokozawa; Eun Ju Cho; Young A Lee; Kinzo Matsumoto; C H Park; Naotoshi Shibahara
Anti-aging effects of oligomeric proanthocyanidins isolated from persimmon fruits.
Drug discoveries & therapeutics 2011;5(3):109-18.
2011: Chan Hum Park; Naotoshi Shibahara; Takashi Tanaka; Ji Hyun Kim; Kinzo Matsumoto; Jeong Sook Noh; Qi Zhao; Takako Yokozawa
Evaluation of morroniside, iridoid glycoside from Corni Fructus, on diabetes-induced alterations such as oxidative stress, inflammation, and apoptosis in the liver of type 2 diabetic db/db mice.
Biological & pharmaceutical bulletin 2011;34(10):1559-65.
2011: Qi Zhao; Takeshi Miyata; Naotoshi Shibahara; Ken Tanaka; Koichi tsuneyama; Takako Yokozawa; Kinzo Matsumoto
Chotosan (Diaoteng San)-induced improvement of cognitive deficits in senescence-accelerated mouse (SAMP8) involves the amelioration of angiogenic/neurotrophic factors and neuroplasticity systems in the brain.
Chinese medicine 2011;6():33.
2011: Chan Hum Park; Jeong Sook Noh; Takashi Tanaka; Kazuo Uebaba; Eun Ju Cho; Takako Yokozawa
The effects of corni fructus extract and its fractions against α-glucosidase inhibitory activities in vitro and sucrose tolerance in normal rats.
The American journal of Chinese medicine 2011;39(2):367-80.
2011: Chan Hum Park; Noriko Yamabe; Takuya Okamoto; Kazuo Toriizuka; Takako Yokozawa
Chinese prescription kangen-karyu ameliorates the development of diabetic hepatic damages via regulating oxidative stress and inflammation in the liver of db/db mice.
Biological & pharmaceutical bulletin 2011;34(3):383-8.
2011: Jeong Sook Noh; Chan Hum Park; Hyun Young Kim; Qi Zhao; Noriko Yamabe; Kinzo Matsumoto; Takako Yokozawa
Chinese prescription Kangen-karyu prevents dyslipidaemia and oxidative stress in mouse model of type 2 diabetes.
The Journal of pharmacy and pharmacology 2011;63(1):111-9.
2010: Noriko Yamabe; Jeong Sook Noh; Chan Hum Park; Ki Sung Kang; Naotoshi Shibahara; Takashi Tanaka; Takako Yokozawa
Evaluation of loganin, iridoid glycoside from Corni Fructus, on hepatic and renal glucolipotoxicity and inflammation in type 2 diabetic db/db mice.
European journal of pharmacology 2010;648(1-3):179-87.
2010: Jeong Sook Noh; Hyun Young Kim; Chan Hum Park; Hajime Fujii; Takako Yokozawa
Hypolipidaemic and antioxidative effects of oligonol, a low-molecular-weight polyphenol derived from lychee fruit, on renal damage in type 2 diabetic mice.
The British journal of nutrition 2010;104(8):1120-8.
2010: Qi Zhao; Takako Yokozawa; Noriko Yamabe; Koichi tsuneyama; Xiaohan Li; Kinzo Matsumoto
Kangen-karyu improves memory deficit caused by aging through normalization of neuro-plasticity-related signaling system and VEGF system in the brain.
Journal of ethnopharmacology 2010;131(2):377-85.
2010: Chan Hum Park; Jeong Sook Noh; Noriko Yamabe; Ki Sung Kang; Takashi Tanaka; Takako Yokozawa
Beneficial effect of 7-O-galloyl-D-sedoheptulose on oxidative stress and hepatic and renal changes in type 2 diabetic db/db mice.
European journal of pharmacology 2010;640(1-3):233-42.
2010: Takako Yokozawa; Noriko Yamabe; Ki Sung Kang; J S Noh; C H Park; Naotoshi Shibahara; Takashi Tanaka
Bioactive constituents of Corni Fructus: The therapeutic use of morroniside, loganin, and 7-O-galloyl-D-sedoheptulose as renoprotective agents in type 2 diabetes.
Drug discoveries & therapeutics 2010;4(4):223-34.
2010: Noriko Yamabe; Hyun Young Kim; Ki Sung Kang; Qi Zhao; Kinzo Matsumoto; Takako Yokozawa
Effect of Chinese prescription Kangen-karyu on lipid metabolism in type 2 diabetic db/db mice.
Journal of ethnopharmacology 2010;129(3):299-305.
2010: Mi Kyung Kim; Sang Woon Chung; Dae Hyun Kim; Ji Min Kim; Eun Kyeong Lee; Ji Young Kim; Young Mi Ha; Yun Hee Kim; Jae-Kyung No; Hye Sun Chung; Kun-Young Park; Sook Hee Rhee; Jae Sue Choi; Byung Pal Yu; Takako Yokozawa; YJ Kim; Hae Young Chung
Modulation of age-related NF-kappaB activation by dietary zingerone via MAPK pathway.
Experimental gerontology 2010;45(6):419-26.
2010: You Jung Kim; Young Ae Kim; Takako Yokozawa
Attenuation of oxidative stress and inflammation by gravinol in high glucose-exposed renal tubular epithelial cells.
Toxicology 2010;270(2-3):106-11.
2010: Ji Min Kim; Eun Kyeong Lee; Gwangli Park; Mi Kyung Kim; Takako Yokozawa; Byung Pal Yu; Hae Young Chung
Morin modulates the oxidative stress-induced NF-kappaB pathway through its anti-oxidant activity.
Free radical research 2010;44(4):454-61.
2010: Chan Hum Park; Jeong Sook Noh; Takashi Tanaka; Takako Yokozawa
Effects of morroniside isolated from Corni Fructus on renal lipids and inflammation in type 2 diabetic mice.
The Journal of pharmacy and pharmacology 2010;62(3):374-80.
2010: Hyun Young Kim; Tsutomu Okubo; Lekh Raj Juneja; Takako Yokozawa
The protective role of amla (Emblica officinalis Gaertn.) against fructose-induced metabolic syndrome in a rat model.
The British journal of nutrition 2010;103(4):502-12.
2010: Young A Lee; Eun Ju Cho; Takako Yokozawa
Oligomeric proanthocyanidins improve memory and enhance phosphorylation of vascular endothelial growth factor receptor-2 in senescence-accelerated mouse prone/8.
The British journal of nutrition 2010;103(4):479-89.
2010: Ki Sung Kang; Noriko Yamabe; Hyun Young Kim; Jeong Hill Park; Takako Yokozawa
Effects of heat-processed ginseng and its active component ginsenoside 20(S)-Rg3 on the progression of renal damage and dysfunction in type 2 diabetic Otsuka Long-Evans Tokushima Fatty rats.
Biological & pharmaceutical bulletin 2010;33(6):1077-81.
2010: Kazuharu Ienaga; Takako Yokozawa
Treatment with NZ-419 (5-Hydroxy-1-methylimidazoline-2,4-dione), a novel intrinsic antioxidant, against the progression of chronic kidney disease at stages 3 and 4 in rats.
Biological & pharmaceutical bulletin 2010;33(5):809-15.
2010: Hyun Ah Jung; Takako Yokozawa; Byung-Woo Kim; Jee H Jung; Jae Sue Choi
Selective inhibition of prenylated flavonoids from Sophora flavescens against BACE1 and cholinesterases.
The American journal of Chinese medicine 2010;38(2):415-29.
2010: Mi Jin Choi; Boh Kyung Kim; Kun Young Park; Takako Yokozawa; Young Ok Song; Eun Ju Cho
Anti-aging effects of cyanidin under a stress-induced premature senescence cellular system.
Biological & pharmaceutical bulletin 2010;33(3):421-6.
2009: Takako Yokozawa; Young A Lee; Qi Zhao; Kinzo Matsumoto; Eun Ju Cho
Persimmon oligomeric proanthocyanidins extend life span of senescence-accelerated mice.
Journal of medicinal food 2009;12(6):1199-205.
2009: You Jung Kim; Young Ae Kim; Takako Yokozawa
Protection against oxidative stress, inflammation, and apoptosis of high-glucose-exposed proximal tubular epithelial cells by astaxanthin.
Journal of agricultural and food chemistry 2009;57(19):8793-7.
2009: Chan Hum Park; Eun Ju Cho; Takako Yokozawa
Protection against hypercholesterolemia by Corni fructus extract and its related protective mechanism.
Journal of medicinal food 2009;12(5):973-81.
2009: Chan Hum Park; Noriko Yamabe; Jeong Sook Noh; Ki Sung Kang; Takashi Tanaka; Takako Yokozawa
The beneficial effects of morroniside on the inflammatory response and lipid metabolism in the liver of db/db mice.
Biological & pharmaceutical bulletin 2009;32(10):1734-40.
2009: Noriko Yamabe; Ki Sung Kang; Jong Moon Hur; Takako Yokozawa
Matcha, a powdered green tea, ameliorates the progression of renal and hepatic damage in type 2 diabetic OLETF rats.
Journal of medicinal food 2009;12(4):714-21.
2009: Hyun Ah Jung; Byung-Sun Min; Takako Yokozawa; Je-Hyun Lee; Yeong Shik Kim; Jae Sue Choi
Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids.
Biological & pharmaceutical bulletin 2009;32(8):1433-8.
2009: Hyun Young Kim; Takuya Okamoto; Takako Yokozawa
Beneficial effects of Chinese prescription Kangen-karyu on diabetes associated with hyperlipidemia, advanced glycation endproducts, and oxidative stress in streptozotocin-induced diabetic rats.
Journal of ethnopharmacology 2009;124(2):263-9.
2009: Kazuharu Ienaga; Hiroki Mikami; Takako Yokozawa
First indications demonstrating the preventive effects of NZ-419, a novel intrinsic antioxidant, on the initiation and/or progression of chronic renal failure in rats.
Biological & pharmaceutical bulletin 2009;32(7):1204-8.
2009: You Jung Kim; Takako Yokozawa
Modulation of oxidative stress and melanogenesis by proanthocyanidins.
Biological & pharmaceutical bulletin 2009;32(7):1155-9.
2009: Eun Kyeong Lee; Sang Woon Chung; Ji Young Kim; Ji Min Kim; Hyoung-Sam Heo; Hyun Ae Lim; Mi Kyung Kim; Stephen Anton; Takako Yokozawa; Hae Young Chung
Allylmethylsulfide Down-Regulates X-Ray Irradiation-Induced Nuclear Factor-kappaB Signaling in C57/BL6 Mouse Kidney.
Journal of medicinal food 2009;12(3):542-51.
2009: Takako Yokozawa; Chan Hum Park; Jeong Sook Noh; Takashi Tanaka; Eun Ju Cho
Novel action of 7-O-galloyl-D-sedoheptulose isolated from Corni Fructus as a hypertriglyceridaemic agent.
The Journal of pharmacy and pharmacology 2009;61(5):653-61.
2009: Sang Woon Chung; Mi Kyung Kim; Jae Heun Chung; Dae Hyun Kim; Jae Sue Choi; Stephen Anton; Arnold Y Seo; Kun-Young Park; Takako Yokozawa; Sook Hee Rhee; Byung Pal Yu; Hae Young Chung
Peroxisome proliferator-activated receptor activation by a short-term feeding of zingerone in aged rats.
Journal of medicinal food 2009;12(2):345-50.
2009: Noriko Yamabe; Ki Sung Kang; Chan Hum Park; Takashi Tanaka; Takako Yokozawa
7-O-galloyl-D-sedoheptulose is a novel therapeutic agent against oxidative stress and advanced glycation endproducts in the diabetic kidney.
Biological & pharmaceutical bulletin 2009;32(4):657-64.
2009: Moon Hee Jang; Hyun Young Kim; Ki Sung Kang; Takako Yokozawa; Jeong Hill Park
Hydroxyl radical scavenging activities of isoquinoline alkaloids isolated from Coptis chinensis.
Archives of pharmacal research 2009;32(3):341-5.
2009: Fengling Pu; Kyoko Motohashi; Tomohiro Kaneko; Yurika Tanaka; Naomi Manome; Keiichi Irie; Jiro Takata; Nobuaki Egashira; Ryozo Oishi; Takuya Okamoto; Yasuo Sei; Takako Yokozawa; Kenichi Mishima; Katsunori Iwasaki; Michihiro Fujiwara
Neuroprotective effects of Kangen-karyu on spatial memory impairment in an 8-arm radial maze and neuronal death in the hippocampal CA1 region induced by repeated cerebral ischemia in rats.
Journal of pharmacological sciences 2009;109(3):424-30.
2009: Michiko Sekiya; Takashi Ichiyanagi; Yasumasa Ikeshiro; Takako Yokozawa
The Chinese prescription Wen-Pi-Tang extract delays disease onset in amyotrophic lateral sclerosis model mice while attenuating the activation of glial cells in the spinal cord.
Biological & pharmaceutical bulletin 2009;32(3):382-8.
2009: Ki Sung Kang; Tetsuaki Tanaka; Eun Ju Cho; Takako Yokozawa
Evaluation of the peroxynitrite scavenging activity of heat-processed ginseng.
Journal of medicinal food 2009;12(1):124-30.
2009: Yani Zou; Dae Hyun Kim; Kyung Jin Jung; Hyoung-Sam Heo; Chul Hong Kim; Hyung Suk Baik; Byung Pal Yu; Takako Yokozawa; Hae Young Chung
Lysophosphatidylcholine enhances oxidative stress via the 5-lipoxygenase pathway in rat aorta during aging.
Rejuvenation research 2009;12(1):15-24.
2008: Eun Ju Cho; Takuya Okamoto; Takako Yokozawa
Therapeutic efficacy of Kangen-karyu against H2O2-induced premature senescence.
The Journal of pharmacy and pharmacology 2008;60(11):1537-44.
2008: Young A Lee; Eun Ju Cho; Takako Yokozawa
Effects of proanthocyanidin preparations on hyperlipidemia and other biomarkers in mouse model of type 2 diabetes.
Journal of agricultural and food chemistry 2008;56(17):7781-9.
2008: Ki Sung Kang; Noriko Yamabe; Hyun Young Kim; Jeong Hill Park; Takako Yokozawa
Therapeutic potential of 20(S)-ginsenoside Rg(3) against streptozotocin-induced diabetic renal damage in rats.
European journal of pharmacology 2008;591(1-3):266-72.
2008: Yong Jae Lee; Hyun Young Kim; Ki Sung Kang; Jin Gyun Lee; Takako Yokozawa; Jeong Hill Park
The chemical and hydroxyl radical scavenging activity changes of ginsenoside-Rb1 by heat processing.
Bioorganic & medicinal chemistry letters 2008;18(16):4515-20.
2008: Takako Yokozawa; Hyun Ju Kim; Eun Ju Cho
Gravinol ameliorates high-fructose-induced metabolic syndrome through regulation of lipid metabolism and proinflammatory state in rats.
Journal of agricultural and food chemistry 2008;56(13):5026-32.
2008: Takako Yokozawa; Noriko Yamabe; Hyun Young Kim; Ki Sung Kang; Jong Moon Hur; Chan Hum Park; Takashi Tanaka
Protective effects of morroniside isolated from Corni Fructus against renal damage in streptozotocin-induced diabetic rats.
Biological & pharmaceutical bulletin 2008;31(7):1422-8.
2008: You Jung Kim; Ki Sung Kang; Takako Yokozawa
The anti-melanogenic effect of pycnogenol by its anti-oxidative actions.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(7):2466-71.
2008: Young A Lee; Eun Ju Cho; Takako Yokozawa
Protective effect of persimmon (Diospyros kaki) peel proanthocyanidin against oxidative damage under H2O2-induced cellular senescence.
Biological & pharmaceutical bulletin 2008;31(6):1265-9.
2008: Ki Sung Kang; Noriko Yamabe; Hyun Young Kim; Takako Yokozawa
Role of maltol in advanced glycation end products and free radicals: in-vitro and in-vivo studies.
The Journal of pharmacy and pharmacology 2008;60(4):445-52.
2008: Ji Young Kim; Hyung Seok Kim; Hye Sook Kang; Jae Sue Choi; Takako Yokozawa; Hae Young Chung
Antioxidant potential of dimethyl lithospermate isolated from Salvia miltiorrhiza (red sage) against peroxynitrite.
Journal of medicinal food 2008;11(1):21-8.
2008: Hyun Young Kim; Yasuyuki Oi; Mujo Kim; Takako Yokozawa
Protective effect of lipoic acid against methylglyoxal-induced oxidative stress in LLC-PK(1) cells.
Journal of nutritional science and vitaminology 2008;54(1):99-104.
2008: Hyun Young Kim; Ki Sung Kang; Noriko Yamabe; Takako Yokozawa
Comparison of the effects of Korean ginseng and heat-processed Korean ginseng on diabetic oxidative stress.
The American journal of Chinese medicine 2008;36(5):989-1004.
2008: Dong Young Rhyu; Ki Sung Kang; Michiko Sekiya; Takashi Tanaka; Jong Cheol Park; Takako Yokozawa
Active compounds isolated from traditional Chinese prescription Wen-Pi-Tang protecting against peroxynitrite-induced LLC-PK(1) cell damage.
The American journal of Chinese medicine 2008;36(4):761-70.
2008: Hyun Young Kim; Da Mi Jeong; Hee Jin Jung; Yu Jung Jung; Takako Yokozawa; Jae Sue Choi
Hypolipidemic effects of Sophora flavescens and its constituents in poloxamer 407-induced hyperlipidemic and cholesterol-fed rats.
Biological & pharmaceutical bulletin 2008;31(1):73-8.
2007: Michiko Sekiya; Yoshiki Kashiwada; Tomo NABEKURA; Shuji Kitagawa; Takashi Yamagishi; Takako Yokozawa; Takashi Ichiyanagi; Yasumasa Ikeshiro; Yoshihisa Takaishi
Effect of triterpenoids isolated from the floral spikes of Betula platyphylla var. japonica on P-glycoprotein function.
Planta medica 2007;73(15):1558-62.
2007: Ki Sung Kang; Noriko Yamabe; H Y Kim; Takako Yokozawa
Effect of sun ginseng methanol extract on lipopolysaccharide-induced liver injury in rats.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2007;14(12):840-5.
2007: Young A Lee; You Jung Kim; Eun Ju Cho; Takako Yokozawa
Ameliorative effects of proanthocyanidin on oxidative stress and inflammation in streptozotocin-induced diabetic rats.
Journal of agricultural and food chemistry 2007;55(23):9395-400.
2007: Takako Yokozawa; You Jung Kim
Piceatannol inhibits melanogenesis by its antioxidative actions.
Biological & pharmaceutical bulletin 2007;30(11):2007-11.
2007: Hyun Young Kim; Ki Sung Kang; Noriko Yamabe; Ryoji Nagai; Takako Yokozawa
Protective effect of heat-processed American ginseng against diabetic renal damage in rats.
Journal of agricultural and food chemistry 2007;55(21):8491-7.
2007: Ki Sung Kang; Yong Jae Lee; Jeong Hill Park; Takako Yokozawa
The effects of glycine and L-arginine on heat stability of ginsenoside Rb1.
Biological & pharmaceutical bulletin 2007;30(10):1975-8.
2007: Ki Sung Kang; Hyun Young Kim; Noriko Yamabe; Jeong Hill Park; Takako Yokozawa
Preventive effect of 20(S)-ginsenoside Rg3 against lipopolysaccharide-induced hepatic and renal injury in rats.
Free radical research 2007;41(10):1181-8.
2007: Takako Yokozawa; Young Ae Kim; Hyun Young Kim; Young A Lee; Gen-ichiro Nonaka
Protective effect of persimmon peel polyphenol against high glucose-induced oxidative stress in LLC-PK(1) cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2007;45(10):1979-87.
2007: Kenichi Kitani; Toshihiko Osawa; Takako Yokozawa
The effects of tetrahydrocurcumin and green tea polyphenol on the survival of male C57BL/6 mice.
Biogerontology 2007;8(5):567-73.
2007: Takako Yokozawa; Hyun Young Kim; Hyun Ju Kim; Takashi Tanaka; Hidetoshi Sugino; Tsutomu Okubo; Djong-Chi Chu; Lekh Raj Juneja
Amla (Emblica officinalis Gaertn.) attenuates age-related renal dysfunction by oxidative stress.
Journal of agricultural and food chemistry 2007;55(19):7744-52.
2007: Ki Sung Kang; Noriko Yamabe; Hyun Young Kim; Takuya Okamoto; Yasuo Sei; Takako Yokozawa
Increase in the free radical scavenging activities of American ginseng by heat processing and its safety evaluation.
Journal of ethnopharmacology 2007;113(2):225-32.
2007: Takako Yokozawa; Hyun Ju Kim; Noriko Yamabe; Takuya Okamoto; Eun Ju Cho
The protective role of Kangen-karyu against fructose-induced metabolic syndrome in a rat model.
The Journal of pharmacy and pharmacology 2007;59(9):1271-8.
2007: Noriko Yamabe; Takako Yokozawa
Protective effect of Hachimi-jio-gan against the development of pancreatic fibrosis and oxidative damage in Otsuka Long-Evans Tokushima Fatty rats.
Journal of ethnopharmacology 2007;113(1):91-9.
2007: Takako Yokozawa; Noriko Yamabe; Ki Sung Kang; Hyun Young Kim
Therapeutic potential of heat-processed Panax ginseng with respect to oxidative tissue damage.
Drug discoveries & therapeutics 2007;1(1):30-44.
2007: Noriko Yamabe; Ki Sung Kang; Yosuke Matsuo; Takashi Tanaka; Takako Yokozawa
Identification of antidiabetic effect of iridoid glycosides and low molecular weight polyphenol fractions of Corni Fructus, a constituent of Hachimi-jio-gan, in streptozotocin-induced diabetic rats.
Biological & pharmaceutical bulletin 2007;30(7):1289-96.
2007: Young A Lee; Eun Ju Cho; Takashi Tanaka; Takako Yokozawa
Inhibitory activities of proanthocyanidins from persimmon against oxidative stress and digestive enzymes related to diabetes.
Journal of nutritional science and vitaminology 2007;53(3):287-92.
2007: Takako Yokozawa; Hyun Young Kim; Hyun Ju Kim; Tsutomu Okubo; Djong-Chi Chu; Lekh Raj Juneja
Amla (Emblica officinalis Gaertn.) prevents dyslipidaemia and oxidative stress in the ageing process.
The British journal of nutrition 2007;97(6):1187-95.
2007: Eun Ju Cho; Takako Yokozawa; Takuya Okamoto
Protective effect of Chinese prescription Kangen-karyu and its crude drug Tanjin against age-related lipidosis in rats.
The Journal of pharmacy and pharmacology 2007;59(5):687-94.
2007: Ki Sung Kang; Takako Yokozawa; Noriko Yamabe; Hyun Young Kim; Jeong Hill Park
ESR study on the structure and hydroxyl radical-scavenging activity relationships of ginsenosides isolated from Panax ginseng C A Meyer.
Biological & pharmaceutical bulletin 2007;30(5):917-21.
2007: Ki Sung Kang; Hyun Young Kim; Seung Hoon Baek; Hye Hyun Yoo; Jeong Hill Park; Takako Yokozawa
Study on the hydroxyl radical scavenging activity changes of ginseng and ginsenoside-Rb2 by heat processing.
Biological & pharmaceutical bulletin 2007;30(4):724-8.
2007: Sumiyo Sasaki; Chihiro Tohda; Mujo Kim; Takako Yokozawa
Gamma-aminobutyric acid specifically inhibits progression of tubular fibrosis and atrophy in nephrectomized rats.
Biological & pharmaceutical bulletin 2007;30(4):687-91.
2007: Takako Nakagawa; Hirozo Goto; Hiroaki Hikiami; Takako Yokozawa; Naotoshi Shibahara; Yutaka Shimada
Protective effects of keishibukuryogan on the kidney of spontaneously diabetic WBN/Kob rats.
Journal of ethnopharmacology 2007;110(2):311-7.
2007: Noriko Yamabe; Ki Sung Kang; Eiko Goto; Takashi Tanaka; Takako Yokozawa
Beneficial effect of Corni Fructus, a constituent of Hachimi-jio-gan, on advanced glycation end-product-mediated renal injury in Streptozotocin-treated diabetic rats.
Biological & pharmaceutical bulletin 2007;30(3):520-6.
2007: Hajime Fujii; Takashi Nakagawa; Hiroshi Nishioka; Eri Sato; Aya Hirose; Yasuhiro Ueno; Buxiang Sun; Takako Yokozawa; Gen-ichiro Nonaka
Preparation, characterization, and antioxidative effects of oligomeric proanthocyanidin-L-cysteine complexes.
Journal of agricultural and food chemistry 2007;55(4):1525-31.
2007: Takako Yokozawa; Young Ae Kim; Hyun-Young Kim; Takuya Okamoto; Yasuo Sei
Protective effect of the Chinese prescription Kangen-karyu against high glucose-induced oxidative stress in LLC-PK1 cells.
Journal of ethnopharmacology 2007;109(1):113-20.
2007: Dong Young Rhyu; Ki Sung Kang; Michiko Sekiya; Takako Yokozawa
Antioxidant effect of Wen-Pi-Tang and its component crude drugs on oxidative stress.
The American journal of Chinese medicine 2007;35(1):127-37.
2006: Takako Yokozawa; Eun Ju Cho; Takuya Okamoto; Yasuo Sei
Effects of the Chinese prescription Kangen-karyu and its crude drug Tanjin on ageing process in rats.
The Journal of pharmacy and pharmacology 2006;58(12):1591-9.
2006: Eun Ju Cho; Young A Lee; Hye Hyun Yoo; Takako Yokozawa
Protective effects of broccoli (Brassica oleracea) against oxidative damage in vitro and in vivo.
Journal of nutritional science and vitaminology 2006;52(6):437-44.
2006: Sumiyo Sasaki; Takako Yokozawa; Eun Ju Cho; Shigeru Oowada; Mujo Kim
Protective role of gamma-aminobutyric acid against chronic renal failure in rats.
The Journal of pharmacy and pharmacology 2006;58(11):1515-25.
2006: Ki Sung Kang; Hyun Young Kim; Noriko Yamabe; Takako Yokozawa
Stereospecificity in hydroxyl radical scavenging activities of four ginsenosides produced by heat processing.
Bioorganic & medicinal chemistry letters 2006;16(19):5028-31.
2006: Noriko Yamabe; Takako Yokozawa; Takeshi Oya; Mujo Kim
Therapeutic potential of (-)-epigallocatechin 3-O-gallate on renal damage in diabetic nephropathy model rats.
The Journal of pharmacology and experimental therapeutics 2006;319(1):228-36.
2006: Hajime Fujii; Takako Yokozawa; Young Ae Kim; Chihiro Tohda; Gen-ichiro Nonaka
Protective effect of grape seed polyphenols against high glucose-induced oxidative stress.
Bioscience, biotechnology, and biochemistry 2006;70(9):2104-11.
2006: Ki Sung Kang; Hyun Young Kim; Noriko Yamabe; Ryoji Nagai; Takako Yokozawa
Protective effect of sun ginseng against diabetic renal damage.
Biological & pharmaceutical bulletin 2006;29(8):1678-84.
2006: Ki Sung Kang; Takako Yokozawa; Hyun Young Kim; Jeong Hill Park
Study on the nitric oxide scavenging effects of ginseng and its compounds.
Journal of agricultural and food chemistry 2006;54(7):2558-62.
2006: Noriko Yamabe; Takako Yokozawa
Activity of the Chinese prescription Hachimi-jio-gan against renal damage in the Otsuka Long-Evans Tokushima fatty rat: a model of human type 2 diabetes mellitus.
The Journal of pharmacy and pharmacology 2006;58(4):535-45.
2006: Hao-Feng Han; Norio Nakamura; Feng Zuo; Akiko Hirakawa; Takako Yokozawa; Masao Hattori
Protective effects of a neutral polysaccharide isolated from the mycelium of Antrodia cinnamomea on Propionibacterium acnes and lipopolysaccharide induced hepatic injury in mice.
Chemical & pharmaceutical bulletin 2006;54(4):496-500.
2006: Takako Yokozawa; Eun Ju Cho; Sumiyo Sasaki; Akiko Satoh; Takuya Okamoto; Yasuo Sei
The protective role of Chinese prescription Kangen-karyu extract on diet-induced hypercholesterolemia in rats.
Biological & pharmaceutical bulletin 2006;29(4):760-5.
2006: Ki Sung Kang; Hyun Young Kim; Jae Sung Pyo; Takako Yokozawa
Increase in the free radical scavenging activity of ginseng by heat-processing.
Biological & pharmaceutical bulletin 2006;29(4):750-4.
2006: Takako Yokozawa; Akiko Satoh; Takako Nakagawa; Noriko Yamabe
Attenuating effects of wen-pi-tang treatment in rats with diabetic nephropathy.
The American journal of Chinese medicine 2006;34(2):307-21.
2006: Hye Hyun Yoo; Takako Yokozawa; Akiko Satoh; Ki Sung Kang; Hyun Young Kim
Effects of ginseng on the proliferation of human lung fibroblasts.
The American journal of Chinese medicine 2006;34(1):137-46.
2005: Hyun Ju Kim; Takako Yokozawa; Hyun Young Kim; Chihiro Tohda; Theertham P Rao; Lekh Raj Juneja
Influence of amla (Emblica officinalis Gaertn.) on hypercholesterolemia and lipid peroxidation in cholesterol-fed rats.
Journal of nutritional science and vitaminology 2005;51(6):413-8.
2005: Noriko Yamabe; Takako Yokozawa; Hyun Young Kim; Eun Ju Cho
Protective effect of Hachimi-jio-gan against renal failure in a subtotal nephrectomy rat model.
The Journal of pharmacy and pharmacology 2005;57(12):1637-44.
2005: You Jung Kim; Takako Yokozawa; Hae Young Chung
Suppression of oxidative stress in aging NZB/NZW mice: effect of fish oil feeding on hepatic antioxidant status and guanidino compounds.
Free radical research 2005;39(10):1101-10.
2005: Akiko Satoh; Takako Yokozawa; Young Ae Kim; Eun Ju Cho; Takuya Okamoto; Yasuo Sei
The mechanisms underlying the anti-aging activity of the Chinese prescription Kangen-karyu in hydrogen peroxide-induced human fibroblasts.
The Journal of pharmacy and pharmacology 2005;57(10):1335-43.
2005: Takako Nakagawa; Takako Yokozawa; Noriko Yamabe; Dong Young Rhyn; Hirozo Goto; Yutaka Shimada; Naotoshi Shibahara
Long-term treatment with Hachimi-jio-gan attenuates kidney damage in spontaneously diabetic WBN/Kob rats.
The Journal of pharmacy and pharmacology 2005;57(9):1205-12.
2005: Takako Nakagawa; Takako Yokozawa; Akiko Satoh; Hyun Young Kim
Attenuation of renal ischemia-reperfusion injury by proanthocyanidin-rich extract from grape seeds.
Journal of nutritional science and vitaminology 2005;51(4):283-6.
2005: Takako Nakagawa; Takako Yokozawa; Hyun Ju Kim; Naotoshi Shibahara
Protective effects of gamma-aminobutyric acid in rats with streptozotocin-induced diabetes.
Journal of nutritional science and vitaminology 2005;51(4):278-82.
2005: Hyun Young Kim; Takako Yokozawa; Eun Ju Cho
Mustard leaf suppresses nitric oxide synthesis by mouse macrophages.
Journal of nutritional science and vitaminology 2005;51(3):200-3.
2005: Xiang Lan Piao; Hyun Young Kim; Takako Yokozawa; Young A Lee; Xiang Shu Piao; Eun Ju Cho
Protective effects of broccoli (Brassica oleracea) and its active components against radical-induced oxidative damage.
Journal of nutritional science and vitaminology 2005;51(3):142-7.
2005: You Jung Kim; Takako Yokozawa; Hae Young Chung
Effects of energy restriction and fish oil supplementation on renal guanidino levels and antioxidant defences in aged lupus-prone B/W mice.
The British journal of nutrition 2005;93(6):835-44.
2005: Takako Yokozawa; Takako Nakagawa; Takeshi Oya; Tsutomu Okubo; Lekh Raj Juneja
Green tea polyphenols and dietary fibre protect against kidney damage in rats with diabetic nephropathy.
The Journal of pharmacy and pharmacology 2005;57(6):773-80.
2005: Takako Yokozawa; Akiko Satoh; Eun Ju Cho; Yoshiki Kashiwada; Yasumasa Ikeshiro
Protective role of Coptidis Rhizoma alkaloids against peroxynitrite-induced damage to renal tubular epithelial cells.
The Journal of pharmacy and pharmacology 2005;57(3):367-74.
2005: Takako Yokozawa; Eun Ju Cho; Dong Young Rhyu; Naotoshi Shibahara; Kazumasa Aoyagi
Glycyrrhizae Radix attenuates peroxynitrite-induced renal oxidative damage through inhibition of protein nitration.
Free radical research 2005;39(2):203-11.
2005: Takako Nakagawa; Takako Yokozawa; Young Ae Kim; Ki Sung Kang; Takashi Tanaka
Activity of wen-pi-tang, and purified constituents of rhei rhizoma and glycyrrhizae radix against glucose-mediated protein damage.
The American journal of Chinese medicine 2005;33(5):817-29.
2005: Theertham P Rao; N Sakaguchi; Lekh Raj Juneja; E Wada; Takako Yokozawa
Amla (Emblica officinalis Gaertn.) extracts reduce oxidative stress in streptozotocin-induced diabetic rats.
Journal of medicinal food 2005;8(3):362-8.
2004: Koichi Yokoyama; Yutaka Shimada; Etsuro Hori; Takako Nakagawa; Shinobu Takagi; Nobuyasu Sekiya; Kazufumi Kouta; Hisao Nishijo; Takako Yokozawa; Katsutoshi Terasawa
Effects of Choto-san and hooks and stems of Uncaria sinensis on antioxidant enzyme activities in the gerbil brain after transient forebrain ischemia.
Journal of ethnopharmacology 2004;95(2-3):335-43.
2004: Hyun Young Kim; Takako Yokozawa; Takako Nakagawa; Sumiyo Sasaki
Protective effect of gamma-aminobutyric acid against glycerol-induced acute renal failure in rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2004;42(12):2009-14.
2004: Takako Yokozawa; M Sekiya; Eun Ju Cho; Masahiko Kurokawa; Kimiyasu Shiraki
Effect of Wen-Pi-Tang extract on lung damage by influenza virus infection.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2004;11(7-8):625-32.
2004: Eun Ju Cho; Takako Yokozawa; S H Rhee; K Y Park
The role of Coptidis Rhizoma extract in a renal ischemia-reperfusion model.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2004;11(7-8):576-84.
2004: Hyun Young Kim; Takako Yokozawa; Eun Ju Cho; Noriko Yamabe
Protective effects of the Chinese prescription Hachimi-jio-gan against diabetic oxidative stress.
The Journal of pharmacy and pharmacology 2004;56(10):1299-305.
2004: Hyun Ah Jung; Hae Young Chung; Takako Yokozawa; Youn-Chul Kim; Sook Kyung Hyun; Jae Sue Choi
Alaternin and emodin with hydroxyl radical inhibitory and/or scavenging activities and hepatoprotective activity on tacrine-induced cytotoxicity in HepG2 cells.
Archives of pharmacal research 2004;27(9):947-53.
2004: Akiko Satoh; Takako Yokozawa; Eun Ju Cho; Takuya Okamoto; Yasuo Sei
Antioxidative effects related to the potential anti-aging properties of the Chinese prescription Kangen-karyu and Carthami Flos in senescence-accelerated mice.
Archives of gerontology and geriatrics 2004;39(1):69-82.
2004: Kenichi Kitani; Takako Yokozawa; Toshihiko Osawa
Interventions in aging and age-associated pathologies by means of nutritional approaches.
Annals of the New York Academy of Sciences 2004;1019():424-6.
2004: Takako Yokozawa; Takako Nakagawa
Inhibitory effects of Luobuma tea and its components against glucose-mediated protein damage.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2004;42(6):975-81.
2004: Takako Nakagawa; Takako Yokozawa; Mitsuyo Sano; Shigeya Takeuchi; Mujo Kim; Shinsuke Minamoto
Activity of (-)-epigallocatechin 3-O-gallate against oxidative stress in rats with adenine-induced renal failure.
Journal of agricultural and food chemistry 2004;52(7):2103-7.
2004: Takako Yokozawa; Ai Ishida; Yoshiki Kashiwada; Eun Ju Cho; Hyun Young Kim; Yasumasa Ikeshiro
Coptidis Rhizoma: protective effects against peroxynitrite-induced oxidative damage and elucidation of its active components.
The Journal of pharmacy and pharmacology 2004;56(4):547-56.
2004: Takako Yokozawa; Dong Young Rhyu; Eun Ju Cho
(-)-Epicatechin 3-O-gallate ameliorates the damages related to peroxynitrite production by mechanisms distinct from those of other free radical inhibitors.
The Journal of pharmacy and pharmacology 2004;56(2):231-9.
2004: Takako Yokozawa; Hyun Young Kim; Noriko Yamabe
Amelioration of diabetic nephropathy by dried Rehmanniae Radix (Di Huang) extract.
The American journal of Chinese medicine 2004;32(6):829-39.
2004: Eun Ju Cho; Takako Yokozawa; Hyun Young Kim; Naotoshi Shibahara; Jong Cheol Park
Rosa rugosa attenuates diabetic oxidative stress in rats with streptozotocin-induced diabetes.
The American journal of Chinese medicine 2004;32(4):487-96.
2004: Takako Yokozawa; Noriko Yamabe; Eun Ju Cho; Takako Nakagawa; Shigeru Oowada
A study on the effects to diabetic nephropathy of Hachimi-jio-gan in rats.
Nephron. Experimental nephrology 2004;97(2):e38-48.
2004: Takako Yokozawa; Akiko Satoh; Eun Ju Cho
Ginsenoside-Rd attenuates oxidative damage related to aging in senescence-accelerated mice.
The Journal of pharmacy and pharmacology 2004;56(1):107-13.
2003: Do Yu Soung; Sook Hee Rhee; Jung Sun Kim; Ji Young Lee; Hee-Sun Yang; Jae Sue Choi; Takako Yokozawa; Yong Nam Han; Hae Young Chung
Peroxynitrite scavenging activity of lithospermate B from Salvia miltiorrhiza.
The Journal of pharmacy and pharmacology 2003;55(10):1427-32.
2003: Takako Yokozawa; Dong Young Rhyu; Eun Ju Cho
Protection by the Chinese prescription Wen-Pi-Tang against renal tubular LLC-PK1 cell damage induced by 3-morpholinosydnonimine.
The Journal of pharmacy and pharmacology 2003;55(10):1405-12.
2003: Takako Yokozawa; Dong Young Rhyu; Eun Ju Cho; Kazumasa Aoyagi
Protective activity of (-)-epicatechin 3-O-gallate against peroxynitrite-mediated renal damage.
Free radical research 2003;37(5):561-71.
2003: Hyun-Young Kim; Takako Yokozawa; Eun Ju Cho; Hong Sik Cheigh; Jae Sue Choi; Hae Young Chung
In vitro and in vivo antioxidant effects of mustard leaf (Brassica juncea).
Phytotherapy research : PTR 2003;17(5):465-71.
2003: Takako Yokozawa; Eun Ju Cho; Takako Nakagawa
Influence of green tea polyphenol in rats with arginine-induced renal failure.
Journal of agricultural and food chemistry 2003;51(8):2421-5.
2003: Takako Yokozawa; Hyun Young Kim Kim; Eun Ju Cho; Noriko Yamabi; Jae Sue Choi
Protective effects of mustard leaf (Brassica juncea) against diabetic oxidative stress.
Journal of nutritional science and vitaminology 2003;49(2):87-93.
2003: Takako Yokozawa; Dong Young Rhyu; Cuiping Chen
Protective effects of Acanthopanax Radix extract against endotoxemia induced by lipopolysaccharide.
Phytotherapy research : PTR 2003;17(4):353-7.
2003: Takako Nakagawa; Takako Yokozawa; Katsutoshi Terasawa; Kazuo Nakanishi
Therapeutic usefulness of Keishi-bukuryo-gan for diabetic nephropathy.
The Journal of pharmacy and pharmacology 2003;55(2):219-27.
2003: Eun Ju Cho; Takako Yokozawa; Dong Young Rhyu; Hyun Young Kim; Naotoshi Shibahara; Jong Cheol Park
The inhibitory effects of 12 medicinal plants and their component compounds on lipid peroxidation.
The American journal of Chinese medicine 2003;31(6):907-17.
2003: Eun Ju Cho; Takako Yokozawa; Dong Young Rhyu; S C Kim; Naotoshi Shibahara; Jong Cheol Park
Study on the inhibitory effects of Korean medicinal plants and their main compounds on the 1,1-diphenyl-2-picrylhydrazyl radical.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2003;10(6-7):544-51.
2003: Takako Yokozawa; A Ishida; Eun Ju Cho; T Nakagawa
The effects of Coptidis Rhizoma extract on a hypercholesterolemic animal model.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2003;10(1):17-22.
2002: Dong Young Rhyu; Takako Yokozawa; Eun Ju Choa; Jong Cheol Park
Prevention of peroxynitrite-induced renal injury through modulation of peroxynitrite production by the Chinese prescription Wen-Pi-Tang.
Free radical research 2002;36(12):1261-9.
2002: Takako Nakagawa; Takako Yokozawa
Direct scavenging of nitric oxide and superoxide by green tea.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2002;40(12):1745-50.
2002: Takako Yokozawa; Hyun Young Kim; Eun Ju Cho; Jae Sue Choi
Protective effects of the BuOH fraction from mustard leaf in a renal ischemia-reperfusion model.
Journal of nutritional science and vitaminology 2002;48(5):384-9.
2002: Takako Yokozawa; Yasuko Muto; Kunihiko Wakaki; Hiroshi Kashiwagi
Site of methylguanidine production and factors that influence production levels.
Nephron 2002;92(2):356-62.
2002: Takako Yokozawa; Hyun Young Kim; Eun Ju Cho; Jae Sue Choi; Hae Young Chung
Antioxidant effects of isorhamnetin 3,7-di-O-beta-D-glucopyranoside isolated from mustard leaf (Brassica juncea) in rats with streptozotocin-induced diabetes.
Journal of agricultural and food chemistry 2002;50(19):5490-5.
2002: Takako Yokozawa; Hyun Young Kim; Eun Ju Cho
Erythritol attenuates the diabetic oxidative stress through modulating glucose metabolism and lipid peroxidation in streptozotocin-induced diabetic rats.
Journal of agricultural and food chemistry 2002;50(19):5485-9.
2002: Takako Yokozawa; Cuiping Chen; Dong Young Rhyu; Takashi Tanaka; Jong Cheol Park; Kenichi Kitani
Potential of sanguiin H-6 against oxidative damage in renal mitochondria and apoptosis mediated by peroxynitrite in vivo.
Nephron 2002;92(1):133-41.
2002: Takako Yokozawa; Takako Nakagawa; Kenichi Kitani
Antioxidative activity of green tea polyphenol in cholesterol-fed rats.
Journal of agricultural and food chemistry 2002;50(12):3549-52.
2002: Takako Yokozawa; Yoshiki Kashiwada; Masao Hattori; Hae Young Chung
Study on the components of luobuma with peroxynitrite-scavenging activity.
Biological & pharmaceutical bulletin 2002;25(6):748-52.
2002: Takako Yokozawa; Hyun Young Kim; Gen-ichiro Nonaka; Kenichi Kosuna
Buckwheat extract inhibits progression of renal failure.
Journal of agricultural and food chemistry 2002;50(11):3341-5.
2002: Takako Nakagawa; Takako Yokozawa; Katsutoshi Terasawa; Seiji Shu; Lekh Raj Juneja
Protective activity of green tea against free radical- and glucose-mediated protein damage.
Journal of agricultural and food chemistry 2002;50(8):2418-22.
2002: Takako Yokozawa; Cuiping Chen; Takashi Tanaka; Kenichi Kitani
Effects of sanguiin H-6, a component of Sanguisorbae Radix, on lipopolysaccharide-stimulated nitric oxide production.
Biochemical pharmacology 2002;63(5):853-8.
2002: Jung Won Kim; Jae Kyung No; Yuji Ikeno; Byung Pal Yu; Jae Sue Choi; Takako Yokozawa; Hae Young Chung
Age-related changes in redox status of rat serum.
Archives of gerontology and geriatrics 2002;34(1):9-17.
2001: Takako Yokozawa; Erbo Dong
Role of ginsenoside-Rd in cisplatin-induced renal injury: special reference to DNA fragmentation.
Nephron 2001;89(4):433-8.
2001: Takako Yokozawa; T Nakagawa; Kunihiko Wakaki; Fumitomo Koizumi
Animal model of diabetic nephropathy.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2001;53(5):359-63.
2001: Takako Yokozawa; Takashi Tanaka; T Kimura
Examination of the nitric oxide production-suppressing component in Tinospora tuberculata.
Biological & pharmaceutical bulletin 2001;24(10):1153-6.
2001: Takako Yokozawa; Hajime Fujii; Kenichi Kosuna; Gen-ichiro Nonaka
Effects of buckwheat in a renal ischemia-reperfusion model.
Bioscience, biotechnology, and biochemistry 2001;65(2):396-400.
2000: Jae Sue Choi; Hae Young Chung; Hyun Ah Jung; Hee-Juhn Park; Takako Yokozawa
Comparative evaluation of antioxidant potential of alaternin (2-hydroxyemodin) and emodin.
Journal of agricultural and food chemistry 2000;48(12):6347-51.
2000: D W Kim; Takako Yokozawa; Masao Hattori; Shigetoshi Kadota; T Namba
Inhibitory effects of an aqueous extract of Apocynum venetum leaves and its constituents on Cu(2+)-induced oxidative modification of low density lipoprotein.
Phytotherapy research : PTR 2000;14(7):501-4.
2000: Takako Yokozawa; Eun Ju Cho; Y Hara; Kenichi Kitani
Antioxidative activity of green tea treated with radical initiator 2, 2'-azobis(2-amidinopropane) dihydrochloride.
Journal of agricultural and food chemistry 2000;48(10):5068-73.
2000: D Kim; Takako Yokozawa; Masao Hattori; Shigetoshi Kadota; Tsuneo Namba
Effects of aqueous extracts of Apocynum venetum leaves on spontaneously hypertensive, renal hypertensive and NaCl-fed-hypertensive rats.
Journal of ethnopharmacology 2000;72(1-2):53-9.
2000: Takako Yokozawa; Erbo Dong; Cuiping Chen
Protection of the kidney by Wen-Pi-Tang against ischemia-reperfusion injury.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2000;7(3):185-9.
2000: Hae Young Chung; Takako Yokozawa; Myoung Sook Kim; K H Lee; K W Kim; R Yang; J H Choi
The mechanism of nitric oxide and/or superoxide cytotoxicity in endothelial cells.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2000;52(3):227-33.
2000: Takako Yokozawa; Cuiping Chen; Takashi Tanaka; Kenichi Kitani
A study on the nitric oxide production-suppressing activity of sanguisorbae radix components.
Biological & pharmaceutical bulletin 2000;23(6):717-22.
2000: Takako Yokozawa; Zhongwu Liu
The role of ginsenoside-Rd in cisplatin-induced acute renal failure.
Renal failure 2000;22(2):115-27.
2000: Takako Yokozawa; Cuiping Chen
Role of Salviae Miltiorrhizae Radix extract and its compounds in enhancing nitric oxide expression.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2000;7(1):55-61.
2000: Takako Yokozawa; T S Wang; Cuiping Chen; Masao Hattori
Inhibition of nitric oxide release by an aqueous extract of Tinospora tuberculata.
Phytotherapy research : PTR 2000;14(1):51-3.
2000: Takako Yokozawa; Cuiping Chen; T Tanaka
Direct scavenging of nitric oxide by traditional crude drugs.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2000;6(6):453-63.
2000: Takako Yokozawa; Zhongwu Liu; Cuiping Chen
Protective effects of Glycyrrhizae radix extract and its compounds in a renal hypoxia (ischemia)-reoxygenation (reperfusion) model.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2000;6(6):439-45.
1999: Cuiping Chen; Takako Yokozawa; Kenichi Kitani
Beneficial effects of sanguisorbae radix in renal dysfunction caused by endotoxin in vivo.
Biological & pharmaceutical bulletin 1999;22(12):1327-30.
1999: Takako Yokozawa; T S Wang; Cuiping Chen; Masao Hattori
Tinospora tuberculata suppresses nitric oxide synthesis in mouse macrophages.
Biological & pharmaceutical bulletin 1999;22(12):1306-9.
1999: Takako Yokozawa; Hae Young Chung; D W Kim; H Goto
Involvement of superoxide and/or nitric oxide in renal tissue injury.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1999;51(6):517-21.
1999: Takako Yokozawa; Takako Nakagawa; K I Lee; Eun Ju Cho; Katsutoshi Terasawa; S Takeuchi
Effects of green tea tannin on cisplatin-induced nephropathy in LLC-PK1 cells and rats.
The Journal of pharmacy and pharmacology 1999;51(11):1325-31.
1999: Takako Yokozawa; S Owada
Effect of ginsenoside-Rd in cephaloridine-induced renal disorder.
Nephron 1999;81(2):200-7.
1999: Jae Kyung No; Do Yu Soung; You Jung Kim; K H Shim; Y S Jun; Sook Hee Rhee; Takako Yokozawa; Hae Young Chung
Inhibition of tyrosinase by green tea components.
Life sciences 1999;65(21):PL241-6.
1999: Cuiping Chen; Takako Yokozawa; Hae Young Chung
Inhibitory effect of caffeic acid analogues isolated from Salviae Miltiorrhizae Radix against 1,1-diphenyl-2-picrylhydrazyl radical.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1999;51(1):59-63.
1999: Takako Yokozawa; Erbo Dong; Y Kawai; M Gemba; M Shimizu
Protective effects of some flavonoids on the renal cellular membrane.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1999;51(1):9-14.
1998: Takako Yokozawa; T Tanaka; Cuiping Chen; I Kouno
Isolation from Wen-Pi-Tang of the active principles possessing antioxidation and radical-scavenging activities.
Phytomedicine : international journal of phytotherapy and phytopharmacology 1998;5(5):367-73.
1998: Takako Yokozawa; Cuiping Chen; Erbo Dong; Takashi Tanaka; Gen-ichiro Nonaka; Itsuo Nishioka
Study on the inhibitory effect of tannins and flavonoids against the 1,1-diphenyl-2 picrylhydrazyl radical.
Biochemical pharmacology 1998;56(2):213-22.
1998: Takako Yokozawa; H Oura; Itsuo Nishioka
Confirmation that magnesium lithospermate B ameliorates paraquat-induced injury in cultured renal epithelial cells.
Nephron 1998;79(3):373-4.
1998: Takako Yokozawa; Erbo Dong; Takako Nakagawa; D W Kim; M Hattori; H Nakagawa
Effects of Japanese black tea on atherosclerotic disorders.
Bioscience, biotechnology, and biochemistry 1998;62(1):44-8.
1998: Takako Yokozawa; Zhongwu Liu; Erbo Dong
A study of ginsenoside-Rd in a renal ischemia-reperfusion model.
Nephron 1998;78(2):201-6.
1997: Takako Yokozawa; Erbo Dong; H Oura; Gen-ichiro Nonaka; Itsuo Nishioka
Magnesium lithospermate B ameliorates cisplatin-induced injury in cultured renal epithelial cells.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1997;49(5):343-6.
1997: Takako Yokozawa; Erbo Dong; Zhongwu Liu; T Shibata; M Hasegawa; H Watanabe; H Oura
Magnesium lithospermate B ameliorates cephaloridine-induced renal injury.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1997;49(5):337-41.
1997: Takako Yokozawa; Erbo Dong
Influence of green tea and its three major components upon low-density lipoprotein oxidation.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1997;49(5):329-35.
1997: Takako Yokozawa; Erbo Dong; Y Kawai; I Nishioka; H Oura; M Gemba
Protective effects of Wen-Pi-Tang against cultured renal epithelial cellular injury.
Phytomedicine : international journal of phytotherapy and phytopharmacology 1997;4(3):245-50.
1997: Takako Yokozawa; Erbo Dong; H Oura
Proof that green tea tannin suppresses the increase in the blood methylguanidine level associated with renal failure.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1997;49(1-2):117-22.
1997: Takako Yokozawa; N Fujitsuka; H Oura; K Ienaga; K Nakamura
In vivo effect of hydroxyl radical scavenger on methylguanidine production from creatinine.
Nephron 1997;75(1):103-5.
1997: Takako Yokozawa; Erbo Dong; H Oura; Hiroshi Kashiwagi; Gen-ichiro Nonaka; Itsuo Nishioka
Magnesium lithospermate B suppresses the increase of active oxygen in rats after subtotal nephrectomy.
Nephron 1997;75(1):88-93.
1997: Takako Yokozawa; Erbo Dong; H Y Chung; H Oura; H Nakagawa
Inhibitory effect of green tea on injury to a cultured renal epithelial cell line, LLC-PK1.
Bioscience, biotechnology, and biochemistry 1997;61(1):204-6.
1996: Takako Yokozawa; T Yasui; H Oura
Molecular biological analysis of the effects of ginsenoside-Rb2 on albumin mRNA in streptozotocin-induced diabetic rats.
The Journal of pharmacy and pharmacology 1996;48(7):763-7.
1996: Takako Yokozawa; Hae Young Chung; L Q He; H Oura
Effectiveness of green tea tannin on rats with chronic renal failure.
Bioscience, biotechnology, and biochemistry 1996;60(6):1000-5.
1995: Takako Yokozawa; Hae Young Chung; Erbo Dong; H Oura
Confirmation that magnesium lithospermate B has a hydroxyl radical-scavenging action.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1995;47(5):341-4.
1995: Takako Yokozawa; H Oura; H Nakagawa; S Sakanaka; M Kim
Effects of a component of green tea on the proliferation of vascular smooth muscle cells.
Bioscience, biotechnology, and biochemistry 1995;59(11):2134-6.
1995: Takako Yokozawa; J J Zhou; Masao Hattori; S Inaba; T Okada; H Oura; Gen-ichiro Nonaka; Itsuo Nishioka
Effects of a Dan Shen component, magnesium lithospermate B, in nephrectomized rats.
Nihon Jinzo Gakkai shi 1995;37(2):105-11.
1994: Takako Yokozawa; J J Zhou; Masao Hattori; S Inaba; T Okada; H Oura
Effects of ginseng in nephrectomized rats.
Biological & pharmaceutical bulletin 1994;17(11):1485-9.
1994: Takako Yokozawa; A Tsuji; H Maeda; Masao Hattori
Study of the effect of a Chinese medical preparation, hokoei-to, on the rat ovary.
Biological & pharmaceutical bulletin 1994;17(6):869-70.
1994: Takako Yokozawa; T Yasui; S Ishii; H Oura
Decrease in the level of albumin mRNA with progression of renal failure in rats.
Nihon Jinzo Gakkai shi 1994;36(4):317-21.
1994: Takako Yokozawa; M Iwano; K Dohi; Masao Hattori; H Oura
Inhibitory effects of ginseng on proliferation of cultured mouse mesangial cells.
Nihon Jinzo Gakkai shi 1994;36(1):13-8.
1994: N Fujitsuka; Takako Yokozawa; H Oura; K Nakamura; K Ienaga
Major role of hydroxyl radical in the conversion of creatinine to creatol.
Nephron 1994;68(2):280-1.
1993: Takako Yokozawa; T W Lee; H Oura; Gen-ichiro Nonaka; Itsuo Nishioka; Masao Hattori
Effect of magnesium lithospermate B on the renal and urinary kallikrein activities in rats with adenine-induced renal failure.
Nihon Jinzo Gakkai shi 1993;35(4):337-42.
1993: Takako Yokozawa; H Oura; M Iwano; K Dohi; Masao Hattori
Inhibitory effects of crude drug components on the proliferation of cultured human mesangial cells.
Nihon Jinzo Gakkai shi 1993;35(4):321-7.
1993: Takako Yokozawa; N Fujitsuka; H Oura; T Akao; K Kobashi; K Ienaga; K Nakamura; Masao Hattori
Purification of methylguanidine synthase from the rat kidney.
Nephron 1993;63(4):452-7.
1993: N Fujitsuka; Takako Yokozawa; H Oura; T Akao; K Kobashi; K Ienaga; K Nakamura
L-gulono-gamma-lactone oxidase is the enzyme responsible for the production of methylguanidine in the rat liver.
Nephron 1993;63(4):445-51.
1993: Takako Yokozawa; H Oura; K Ienaga; K Nakamura
Comparison of renal effects of creatinine, creatol and methylguanidine in rats with adenine-induced chronic renal failure.
Nephron 1993;64(3):424-8.
1993: Takako Yokozawa; K Fujioka; H Oura; Gen-ichiro Nonaka; Itsuo Nishioka
Effects of rhubarb tannins on renal function in rats with renal failure.
Nihon Jinzo Gakkai shi 1993;35(1):13-8.
1993: Takako Yokozawa; H Oura; Masao Hattori; M Iwano; K Dohi; S Sakanaka; M Kim
Inhibitory effect of tannin in green tea on the proliferation of mesangial cells.
Nephron 1993;65(4):596-600.
1992: Takako Yokozawa; H Oura; K Ienaga; K Nakamura
Effects of creatinine, creatol and methylguanidine on renal function.
Nihon Jinzo Gakkai shi 1992;34(9):973-7.
1992: Takako Yokozawa; T W Lee; H Oura; Gen-ichiro Nonaka; Itsuo Nishioka
Effect of magnesium lithospermate B in rats with sodium-induced hypertension and renal failure.
Nephron 1992;60(4):460-5.
1991: Takako Yokozawa; H Oura
Increased hepatic adenine nucleotide content by ginseng.
Journal of ethnopharmacology 1991;34(1):79-82.
1991: Takako Yokozawa; N Fujitsuka; T Yasui; H Oura
Effects of ginsenoside-Rb2 on adenine nucleotide content of rat hepatic tissue.
The Journal of pharmacy and pharmacology 1991;43(4):290-1.
1991: Takako Yokozawa; Hae Young Chung; T W Lee; H Oura; Gen-ichiro Nonaka; I Nishioka
Potentiating effect of converting enzyme inhibitor captopril to the renal responses of magnesium lithospermate B in rats with adenine-induced renal failure.
Chemical & pharmaceutical bulletin 1991;39(3):732-6.
1991: Takako Yokozawa; H Oura; T W Lee; Gen-ichiro Nonaka; Itsuo Nishioka
Augmentation of renal response by magnesium lithospermate B.
Nephron 1991;57(1):78-83.
1991: Takako Yokozawa; K Fujioka; H Oura; Gen-ichiro Nonaka; Itsuo Nishioka
Effects of rhubarb tannins on uremic toxins.
Nephron 1991;58(2):155-60.
1991: Takako Yokozawa; N Fujitsuka; H Oura
Studies on the precursor of methylguanidine in rats with renal failure.
Nephron 1991;58(1):90-4.
1991: Takako Yokozawa; N Fujitsuka; H Oura; K Ienaga; K Nakamura
Comparison of methylguanidine production from creatinine and creatol in vivo.
Nephron 1991;58(1):125-6.
1991: K Nakamura; K Ienaga; Takako Yokozawa; N Fujitsuka; H Oura
Production of methylguanidine from creatinine via creatol by active oxygen species: analyses of the catabolism in vitro.
Nephron 1991;58(1):42-6.
1990: Takako Yokozawa; H Oura
Facilitation of protein biosynthesis by ginsenoside-Rb2 administration in diabetic rats.
Journal of natural products 1990;53(6):1514-8.
1990: Takako Yokozawa; T W Lee; Hae Young Chung; H Oura; Gen-ichiro Nonaka; Itsuo Nishioka
Renal responses to magnesium lithospermate B.
The Journal of pharmacy and pharmacology 1990;42(10):712-5.
1990: Takako Yokozawa; Hae Young Chung; T W Lee; H Oura; Gen-ichiro Nonaka; Itsuo Nishioka
Magnesium lithospermate B improves renal function via the kallikrein-prostaglandin system in rats with renal failure.
Nihon Jinzo Gakkai shi 1990;32(8):893-8.
1990: Takako Yokozawa; T W Lee; Hae Young Chung; H Oura; Gen-ichiro Nonaka; I Nishioka
Effect of magnesium lithospermate B on urinary prostaglandins in rats with renal failure.
Journal of natural products 1990;53(3):662-5.
1990: Takako Yokozawa; N Fujitsuka; H Oura
Production of methylguanidine from creatinine in normal rats and rats with renal failure.
Nephron 1990;56(3):249-54.
1989: Takako Yokozawa; H Oura; Y Kawashima
The effect of ginsenoside-Rb2 on nitrogen balance.
Journal of natural products 1989;52(6):1350-2.
1989: Takako Yokozawa; Hae Young Chung; H Oura; Gen-ichiro Nonaka; I Nishioka
Isolation of a renal function-facilitating constituent from the Oriental drug, salviae miltiorrhizae radix.
Nihon Jinzo Gakkai shi 1989;31(10):1091-8.
1989: Takako Yokozawa; Hae Young Chung; T W Lee; H Oura; T Tanaka; Gen-ichiro Nonaka; I Nishioka
Effect of magnesium lithospermate B on urinary excretion of arachidonate metabolites in rats with renal failure.
Chemical & pharmaceutical bulletin 1989;37(10):2766-9.
1989: Takako Yokozawa; Hae Young Chung; T W Lee; H Oura; T Tanaka; Gen-ichiro Nonaka; I Nishioka; A Hirai
Contribution of prostaglandins to the renal responses to magnesium lithospermate B isolated from salviae miltiorrhizae radix.
Chemical & pharmaceutical bulletin 1989;37(6):1568-71.
1989: Takako Yokozawa; Z L Mo; H Oura
Comparison of toxic effects of methylguanidine, guanidinosuccinic acid and creatinine in rats with adenine-induced chronic renal failure.
Nephron 1989;51(3):388-92.
1989: Takako Yokozawa; N Fujitsuka; H Oura
Variations in the distribution of methylguanidine with the progression of renal failure after methylguanidine loading.
Nephron 1989;52(4):347-51.
1988: Takako Yokozawa; Hae Young Chung; H Oura; Gen-ichiro Nonaka; I Nishioka
Isolation of the active component having the uremia-preventive effect from salviae miltiorrhizae radix extract.
Chemical & pharmaceutical bulletin 1988;36(1):316-20.