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Fumio Yoneda

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Toshiaki Saitoh; Kenji Abe; Masami Ishikawa; Masanao Nakatani; Seiichiro Shimazu; Noriyuki Satoh; Fumio Yoneda; Kyoji Taguchi; Yoshie Horiguchi
Synthesis and in vitro cytotoxicity of 1,2,3,4-tetrahydroisoquinoline derivatives.
Kazue Takahata; Seiichiro Shimazu; Hiroshi Katsuki; Fumio Yoneda; Akinori Akaike
Effects of selegiline on antioxidant systems in the nigrostriatum in rat.
Seiichiro Shimazu; Akiko Minami; Haruko Kusumoto; Fumio Yoneda
Antidepressant-like effects of selegiline in the forced swim test.

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2006: Toshiaki Saitoh; Kenji Abe; Masami Ishikawa; Masanao Nakatani; Seiichiro Shimazu; Noriyuki Satoh; Fumio Yoneda; Kyoji Taguchi; Yoshie Horiguchi
Synthesis and in vitro cytotoxicity of 1,2,3,4-tetrahydroisoquinoline derivatives.
European journal of medicinal chemistry 2006;41(2):241-52.
2006: Kazue Takahata; Seiichiro Shimazu; Hiroshi Katsuki; Fumio Yoneda; Akinori Akaike
Effects of selegiline on antioxidant systems in the nigrostriatum in rat.
Journal of neural transmission (Vienna, Austria : 1996) 2006;113(2):151-8.
2005: Seiichiro Shimazu; Akiko Minami; Haruko Kusumoto; Fumio Yoneda
Antidepressant-like effects of selegiline in the forced swim test.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2005;15(5):563-71.
2005: Kazue Takahata; Akiko Minami; Haruko Kusumoto; Seiichiro Shimazu; Fumio Yoneda
Effects of selegiline alone or with donepezil on memory impairment in rats.
European journal of pharmacology 2005;518(2-3):140-4.
2005: Chieko Hirami; Kazue Takahata; Seiichiro Shimazu; Fumio Yoneda; Kyozo Hayashi; Hiroshi Katsuki; Akinori Akaike
Effects of R-(-)-BPAP on the expressions of neurotrophins and their receptors in mesencephalic slices.
Biological & pharmaceutical bulletin 2005;28(8):1524-6.
2004: Nobuyoshi Norisada; Hiroaki Masuzaki; Muneya Fujimoto; Gen Inoue; Kiminori Hosoda; Tatsuya Hayashi; Mayumi Watanabe; Shizuko Muraoka; Fumio Yoneda; Kazuwa Nakao
Antidiabetic and adipogenic properties in a newly synthesized thiazolidine derivative, FPFS-410.
Metabolism: clinical and experimental 2004;53(12):1532-7.
2004: Wakako Maruyama; Hong Yi; Tsutomu Takahashi; Seiichiro Shimazu; Hironori Ohde; Fumio Yoneda; Kinuko Iwasa; Makoto Naoi
Neuroprotective function of R-(-)-1-(benzofuran-2-yl)-2-propylaminopentane, [R-(-)-BPAP], against apoptosis induced by N-methyl(R)salsolinol, an endogenous dopaminergic neurotoxin, in human dopaminergic neuroblastoma SH-SY5Y cells.
Life sciences 2004;75(1):107-17.
2004: Kazue Takahata; Seiichiro Shimazu; Fumio Yoneda
(-)-Deprenyl inhibits tyramine-induced noradrenaline release, but not tyramine-induced dopamine release or potassium-induced noradrenaline release, from rat brain synaptosomes.
Pharmacological research : the official journal of the Italian Pharmacological Society 2004;49(3):253-8.
2003: Seiichiro Shimazu; Hiroko Tsunekawa; Fumio Yoneda; Hiroshi Katsuki; Akinori Akaike; Aaron Janowsky
Transporter-mediated actions of R-(-)-1-(benzofuran-2-yl)-2-propylaminopentane.
European journal of pharmacology 2003;482(1-3):9-16.
2003: Kazue Takahata; Hiroshi Katsuki; Toshiaki Kume; Ken Ito; Yoshinaga Tochikawa; Shizuko Muraoka; Fumio Yoneda; Satoshi Kashii; Yoshihito Honda; Akinori Akaike
Retinal neurotoxicity of nitric oxide donors with different half-life of nitric oxide release: involvement of N-methyl-D-aspartate receptor.
Journal of pharmacological sciences 2003;92(4):428-32.
2003: Seiichiro Shimazu; Kazue Takahata; A Tamashiro; Fumio Yoneda; Yasuhiko Iida; Hideo Saji
Recovery of motor function and dopaminergic parameters in a mouse model of Parkinson's disease induced by co-administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and diethyldithiocarbamate.
Journal of neural transmission (Vienna, Austria : 1996) 2003;110(8):871-83.
2003: Kazue Takahata; Seiichiro Shimazu; Fumio Yoneda; M Ogawa; Yasuhiko Iida; Hideo Saji
Effects of monoamine oxidase inhibitors on the diethyldithiocarbamate-induced enhancement of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in C57BL/6 mice.
Journal of neural transmission (Vienna, Austria : 1996) 2003;110(8):859-69.
2003: Seiichiro Shimazu; Akie Tanigawa; Noriyuki Sato; Fumio Yoneda; Kyozo Hayashi; Joseph Knoll
Enhancer substances: selegiline and R-(-)-1-(benzofuran-2-yl)-2-propylaminopentane [(-)-BPAP] enhance the neurotrophic factor synthesis on cultured mouse astrocytes.
Life sciences 2003;72(24):2785-92.
2003: Kazue Takahata; Hiroshi Katsuki; Toshiaki Kume; Daisuke Nakata; Ken Ito; Shizuko Muraoka; Fumio Yoneda; Satoshi Kashii; Yoshihito Honda; Akinori Akaike
Retinal neuronal death induced by intraocular administration of a nitric oxide donor and its rescue by neurotrophic factors in rats.
Investigative ophthalmology & visual science 2003;44(4):1760-6.
2003: Seiichiro Shimazu; Akiko Tamashiro; Fumio Yoneda; Joseph Knoll
The L-DOPA-sparing effect of R-(-)-1-(benzofuran-2-yl)-2-propylaminopentane hydrochloride [(-)-BPAP] in reserpine-pretreated rats.
Life sciences 2003;72(12):1413-9.
2003: Hideo Saji; Yasuhiko Iida; Hidekazu Kawashima; Mikako Ogawa; Youji Kitamura; Takahiro Mukai; Seiichiro Shimazu; Fumio Yoneda
In vivo imaging of brain dopaminergic neurotransmission system in small animals with high-resolution single photon emission computed tomography.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 2003;19(1):67-71.
2003: Kazue Takahata; Hiroshi Katsuki; Yutaka Kobayashi; Shizuko Muraoka; Fumio Yoneda; Toshiaki Kume; Satoshi Kashii; Yoshihito Honda; Akinori Akaike
Protective effects of selegiline and desmethylselegiline against N-methyl-D-aspartate-induced rat retinal damage.
European journal of pharmacology 2003;458(1-2):81-9.
2002: Joseph Knoll; Ildikó Miklya; Berta Knoll; Takuya Yasusa; Seiichiro Shimazu; Fumio Yoneda
1-(Benzofuran-2-yl)-2-(3,3,3-trifluoropropyl)aminopentane HCl, 3-F-BPAP, antagonizes the enhancer effect of (-)-BPAP in the shuttle box and leaves the effect of (-)-deprenyl unchanged.
Life sciences 2002;71(17):1975-84.
2002: Kiyoe Ohta; Mitsuhiro Ohta; Ikuko Mizuta; Aya Fujinami; Seiichiro Shimazu; Noriyuki Sato; Fumio Yoneda; Kyozo Hayashi; Sadako Kuno
The novel catecholaminergic and serotoninergic activity enhancer R-(-)-1-(benzofuran-2-yl)-2-propylaminopentane up-regulates neurotrophic factor synthesis in mouse astrocytes.
Neuroscience letters 2002;328(3):205-8.
2001: T Kawamoto; Y Ikeuchi; Yuji Mikata; MK Kishigami; Shigenobu Yano; C Murayama; T Mori; Fumio Yoneda
Promotion of radiation-induced formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine by nitro 5-deazaflavin derivatives.
Bioorganic & medicinal chemistry letters 2001;11(13):1745-8.
2001: Seiichiro Shimazu; Kazue Takahata; Hiroshi Katsuki; H Tsunekawa; A Tanigawa; Fumio Yoneda; Joseph Knoll; Akinori Akaike
(-)-1-(Benzofuran-2-yl)-2-propylaminopentane enhances locomotor activity in rats due to its ability to induce dopamine release.
European journal of pharmacology 2001;421(3):181-9.
2001: T Oka; Takuya Yasusa; T Ando; M Watanabe; Fumio Yoneda; T Ishida; Joseph Knoll
Enantioselective synthesis and absolute configuration of (-)-1-(benzofuran-2-yl)-2-propylaminopentane, ((-)-BPAP), a highly potent and selective catecholaminergic activity enhancer.
Bioorganic & medicinal chemistry 2001;9(5):1213-9.
2001: Fumio Yoneda; T Moto; M Sakae; Hironori Ohde; Berta Knoll; Ildikó Miklya; Joseph Knoll
Structure-activity studies leading to (-)1-(benzofuran-2-yl)-2-propylaminopentane, ((-)BPAP), a highly potent, selective enhancer of the impulse propagation mediated release of catecholamines and serotonin in the brain.
Bioorganic & medicinal chemistry 2001;9(5):1197-212.
2000: Wakako Hamabe; R Fujita; Takuya Yasusa; Fumio Yoneda; A Yoshida; Hiroshi Ueda
(-)1-(Benzofuran-2-yl)-2-propylaminopentane shows survival effect on cortical neurons under serum-free condition through sigma receptors.
Cellular and molecular neurobiology 2000;20(6):695-702.
2000: Y Ikeuchi; M Sumiya; T Kawamoto; Naomi Akimoto; Yuji Mikata; MK Kishigami; Shigenobu Yano; T Sasaki; Fumio Yoneda
Synthesis and antitumor activities of novel 5-deazaflavin-sialic acid conjugate molecules.
Bioorganic & medicinal chemistry 2000;8(8):2027-35.
1999: Joseph Knoll; Fumio Yoneda; Berta Knoll; Hironori Ohde; Ildikó Miklya
(-)1-(Benzofuran-2-yl)-2-propylaminopentane, [(-)BPAP], a selective enhancer of the impulse propagation mediated release of catecholamines and serotonin in the brain.
British journal of pharmacology 1999;128(8):1723-32.
1999: H Ikeda; Kaoru Fuji; K Tanaka; Y Iso; Fumio Yoneda
DNA oligomers having a diazapyrenium dication (DAP2+); synthesis and DNA cleavage activities.
Chemical & pharmaceutical bulletin 1999;47(10):1455-63.
1999: Yuji Mikata; MK Kishigami; M Nishida; Shigenobu Yano; T Kawamoto; Y Ikeuchi; Fumio Yoneda
Formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine under anaerobic conditions by reductively activated nitro 5-deazaflavin derivatives.
Bioorganic & medicinal chemistry letters 1999;9(15):2141-4.
1998: Y Kanaoka; Y Ikeuchi; T Kawamoto; K Bessho; Naomi Akimoto; Yuji Mikata; M Nishida; Shigenobu Yano; T Sasaki; Fumio Yoneda
Synthesis and evaluation of nitro 5-deazaflavin-pyrrolecarboxamide(s) hybrid molecules as novel DNA targeted bioreductive antitumor agents.
Bioorganic & medicinal chemistry 1998;6(3):301-14.
1995: T Miyao; Yoshinobu Takakura; Taishin Akiyama; Fumio Yoneda; H Sezaki; M Hashida
Stability and pharmacokinetic characteristics of oligonucleotides modified at terminal linkages in mice.
Antisense research and development 1995;5(2):115-21.
1993: Y Nakamura; Taishin Akiyama; Kazuhisa Bessho; Fumio Yoneda
Convenient syntheses of oligonucleotides linked to 5-deazaflavin coenzyme models at 3'-end. Incorporation of 5-deazaflavin to controlled pore glass (CPG) support.
Chemical & pharmaceutical bulletin 1993;41(7):1315-7.
1993: Y Nakamura; Taishin Akiyama; Y Yoneda; K Tanaka; Fumio Yoneda
Redox potential of oligonucleotide linked to 5-deazaflavin coenzyme model. Detection of hybrid formation by cyclic voltammometry.
Chemical & pharmaceutical bulletin 1993;41(4):778-80.
1993: T Nagamatsu; H Yamasaki; T Hirota; M Yamato; Y Kido; M Shibata; Fumio Yoneda
Syntheses of 3-substituted 1-methyl-6-phenylpyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-diones (6-phenyl analogs of toxoflavin) and their 4-oxides, and evaluation of antimicrobial activity of toxoflavins and their analogs.
Chemical & pharmaceutical bulletin 1993;41(2):362-8.
1991: Fumio Yoneda; Taishin Akiyama; M Ohno; R Yanada; T Harayama
On the conversion of thymidine phosphate bromohydrins to thymidine phosphates: a model reaction for the repair of oxidized nucleotides.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1991;111(6):284-92.
1991: T Harayama; R Yanada; Taishin Akiyama; M Tanaka; Y Fujita; Fumio Yoneda
On the repair of thymine and thymidine bromohydrins: a possible new model for the damage and repair of nucleic acids.
Chemical & pharmaceutical bulletin 1991;39(3):612-5.
1991: Taishin Akiyama; Fumio Yoneda; K Tanaka; J Kuwabara; Yukio Sugiura
Synthesis and characterization of flavin modified oligodeoxyribonucleotide.
Nucleic acids symposium series 1991;(25):69-70.
1991: H Ikeda; K Tanaka; Kaoru Fuji; Y Iso; Fumio Yoneda
Synthesis and characterization of viologen-modified oligodeoxynucleotides.
Nucleic acids symposium series 1991;(25):99-100.
1990: Taishin Akiyama; K Tanaka; Kazuhisa Bessho; Fumio Yoneda
The reductive repair of adenine-1-oxide derivatives to adenine derivatives by gamma-glutamylcysteinylglycine (glutathione).
Chemical & pharmaceutical bulletin 1990;38(10):2893-5.
1988: T Harayama; R Yanada; Taishin Akiyama; M Tanaka; Y Fujita; Fumio Yoneda
A model reaction for the repair of nucleic acids. The repair of thymidine bromohydrins.
Nucleic acids symposium series 1988;(19):107-10.
1987: T Harayama; R Yanada; Taishin Akiyama; M Tanaka; Fumio Yoneda
On the repair of thymidine bromohydrins, damaged nucleosides: a possible new model for the damage and repair of nucleic acids.
Biochemical and biophysical research communications 1987;148(3):995-1000.
1987: Fumio Yoneda; K Tanaka
The biofunctional chemistry of 5-deazaflavins and related compounds.
Medicinal research reviews 1987;7(4):477-506.
1986: T Harayama; R Yanada; K Iio; Fumio Yoneda
On the cross-coupling reaction of 1,3-dimethylthymine and thymidine epoxides with nucleophiles.
Nucleic acids symposium series 1986;(17):25-8.
1985: T Harayama; R Yanada; T Taga; K Machida; Fumio Yoneda
On the reactions of DL-1,3-dimethylthymine epoxide with amines and L-amino acid derivatives.
Nucleic acids symposium series 1985;(16):73-6.
1984: T Harayama; R Yanada; K Kotoji; Fumio Yoneda; T Taga; K Osaki; T Nagamatsu
Studies on oxidative modifications of nucleic acid pyrimidine bases.
Nucleic acids symposium series 1984;(15):1-4.