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Hong Yong

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Zhonghua Pei; Xiaofeng Li; Thomas W von Geldern; David J Madar; Kenton Longenecker; Hong Yong; Thomas H Lubben; Kent D Stewart; Bradley A Zinker; Bradley J Backes; Andrew S Judd; Mathew M Mulhern; Stephen J Ballaron; Michael Stashko; Amanda K Mika; David W A Beno; Glenn A Reinhart; Ryan M Fryer; Lee C Preusser; Anita J Kempf-Grote; Hing L Sham; James M Trevillyan
Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Vince S C Yeh; Jyoti R Patel; Hong Yong; Ravi Kurukulasuriya; Steven Fung; Katina Monzon; William Chiou; Jiahong Wang; Deanne Stolarik; Hovis Imade; David W A Beno; Michael Brune; Peer Jacobson; Hing L Sham; James T Link
Synthesis and biological evaluation of heterocycle containing adamantane 11beta-HSD1 inhibitors.
Kenton Longenecker; Kent D Stewart; David J Madar; Clarissa Jakob; Elizabeth H Fry; Sherwin Wilk; Chun W Lin; Stephen J Ballaron; Michael Stashko; Thomas H Lubben; Hong Yong; Daisy Pireh; Zhonghua Pei; Fatima Basha; Paul E Wiedeman; Thomas W von Geldern; James M Trevillyan; Vincent S Stoll
Crystal structures of DPP-IV (CD26) from rat kidney exhibit flexible accommodation of peptidase-selective inhibitors.

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All Publications

2006: Zhonghua Pei; Xiaofeng Li; Thomas W von Geldern; David J Madar; Kenton Longenecker; Hong Yong; Thomas H Lubben; Kent D Stewart; Bradley A Zinker; Bradley J Backes; Andrew S Judd; Mathew M Mulhern; Stephen J Ballaron; Michael Stashko; Amanda K Mika; David W A Beno; Glenn A Reinhart; Ryan M Fryer; Lee C Preusser; Anita J Kempf-Grote; Hing L Sham; James M Trevillyan
Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Journal of medicinal chemistry 2006;49(22):6439-42.
2006: Vince S C Yeh; Jyoti R Patel; Hong Yong; Ravi Kurukulasuriya; Steven Fung; Katina Monzon; William Chiou; Jiahong Wang; Deanne Stolarik; Hovis Imade; David W A Beno; Michael Brune; Peer Jacobson; Hing L Sham; James T Link
Synthesis and biological evaluation of heterocycle containing adamantane 11beta-HSD1 inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(20):5414-9.
2006: Kenton Longenecker; Kent D Stewart; David J Madar; Clarissa Jakob; Elizabeth H Fry; Sherwin Wilk; Chun W Lin; Stephen J Ballaron; Michael Stashko; Thomas H Lubben; Hong Yong; Daisy Pireh; Zhonghua Pei; Fatima Basha; Paul E Wiedeman; Thomas W von Geldern; James M Trevillyan; Vincent S Stoll
Crystal structures of DPP-IV (CD26) from rat kidney exhibit flexible accommodation of peptidase-selective inhibitors.
Biochemistry 2006;45(24):7474-82.
2005: Hong Yong; Yu Gui Gu; Richard F Clark; Thomas Marron; Zhenkun Ma; Niru B Soni; Gregory G Stone; Angela M Nilius; Kennan Marsh; Stevan W Djuric
Design, synthesis and structure-activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae.
Bioorganic & medicinal chemistry letters 2005;15(10):2653-8.
2004: Irini Akritopoulou-Zanze; Kathleen M Phelan; Thomas Marron; Hong Yong; Zhenkun Ma; Gregory G Stone; Melissa M Daly; Dena M Hensey; Angela M Nilius; Stevan W Djuric
Synthesis and antibacterial activity of novel bifunctional macrolides.
Bioorganic & medicinal chemistry letters 2004;14(14):3809-13.
2001: Zhenkun Ma; Richard F Clark; A Brazzale; Sanyi Wang; Michael Rupp; Leping Li; G Griesgraber; Suoming Zhang; Hong Yong; Ly T Phan; P A Nemoto; Daniel T Chu; Jacob J Plattner; Xiaolin Zhang; Ping Zhong; Zhensheng Cao; Angela M Nilius; Virginia D Shortridge; Robert K Flamm; Michael J Mitten; Jonathan A Meulbroek; PJ Ewing; JD Alder; Yat Sun Or
Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens.
Journal of medicinal chemistry 2001;44(24):4137-56.
2000: Richard F Clark; Zhenkun Ma; Sanyi Wang; G Griesgraber; Michael Tufano; Hong Yong; Leping Li; Xiaolin Zhang; Angela M Nilius; Daniel T Chu; Yat Sun Or
Synthesis and antibacterial activity of novel 6-O-substituted erythromycin A derivatives.
Bioorganic & medicinal chemistry letters 2000;10(8):815-9.