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James Broach

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Living Beings

Saccharomyces cerevisiae

Physiology

Chemicals & Drugs

Genes & Molecular Sequences

Concepts & Ideas

Molecular Sequence Data

Anatomy

Fungal Chromosomes

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Network (preview)

Co-Publications
Name
7
Schneper, Lisa
7
Peiper, Stephen
5
Deschenes, Robert
4
Düvel, Katrin
4
Fujii, Nobutaka
3
Houston, Peter
3
Navenot, Jean-Marc
3
Zhang, Wen-Bo
3
Manfredi, John
3
Floudas, Christodoulos
2
Santhanam, Arti
2
Levine, AJ
2
Tamamura, Hirokazu
2
Tavazoie, Saeed
2
Wang, Zixuan

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Publications

TOP 3
Zawadzki Karl A; Morozov Alexandre V; Broach James R
Chromatin-dependent transcription factor accessibility rather than nucleosome remodeling predominates during global transcriptional restructuring in Saccharomyces cerevisiae.
Freckleton Gordon; Lippman Soyeon I; Broach James R; Tavazoie Saeed
Microarray profiling of phage-display selections for rapid mapping of transcription factor-DNA interactions.
Airoldi Edoardo M; Huttenhower Curtis; Gresham David; Lu Charles; Caudy Amy A; Dunham Maitreya J; Broach James R; Botstein David; Troyanskaya Olga G
Predicting cellular growth from gene expression signatures.

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All Publications

2009: Zawadzki Karl A; Morozov Alexandre V; Broach James R
Chromatin-dependent transcription factor accessibility rather than nucleosome remodeling predominates during global transcriptional restructuring in Saccharomyces cerevisiae.
Molecular biology of the cell 2009;20(15):3503-13.
2009: Freckleton Gordon; Lippman Soyeon I; Broach James R; Tavazoie Saeed
Microarray profiling of phage-display selections for rapid mapping of transcription factor-DNA interactions.
PLoS genetics 2009;5(4):e1000449.
2009: Airoldi Edoardo M; Huttenhower Curtis; Gresham David; Lu Charles; Caudy Amy A; Dunham Maitreya J; Broach James R; Botstein David; Troyanskaya Olga G
Predicting cellular growth from gene expression signatures.
PLoS computational biology 2009;5(1):e1000257.
2009: Evans Barry J; Wang Zixuan; Broach James R; Oishi Shinya; Fujii Nobutaka; Peiper Stephen C
Expression of CXCR4, a G-protein-coupled receptor for CXCL12 in yeast identification of new-generation inverse agonists.
Methods in enzymology 2009;460():399-412.
2009: Zaman Shadia; Lippman Soyeon I; Schneper Lisa; Slonim Noam; Broach James R
Glucose regulates transcription in yeast through a network of signaling pathways.
Molecular systems biology 2009;5():245.
2008: Tan Meng P; Smith Erin N; Broach James R; Floudas Christodoulos A
Microarray data mining: a novel optimization-based approach to uncover biologically coherent structures.
BMC bioinformatics 2008;9():268.
2008: Zaman Shadia; Lippman Soyeon Im; Zhao Xin; Broach James R
How Saccharomyces responds to nutrients.
Annual review of genetics 2008;42():27-81.
2007: Yorimitsu Tomohiro; Zaman Shadia; Broach James R; Klionsky Daniel J
Protein kinase A and Sch9 cooperatively regulate induction of autophagy in Saccharomyces cerevisiae.
Molecular biology of the cell 2007;18(10):4180-9.
2007: Tan Meng P; Broach James R; Floudas Christodoulos A
Evaluation of normalization and pre-clustering issues in a novel clustering approach: global optimum search with enhanced positioning.
Journal of bioinformatics and computational biology 2007;5(4):895-913.
2007: Urban Jörg; Soulard Alexandre; Huber Alexandre; Lippman Soyeon; Mukhopadhyay Debdyuti; Deloche Olivier; Wanke Valeria; Anrather Dorothea; Ammerer Gustav; Riezman Howard; Broach James R; De Virgilio Claudio; Hall Michael N; Loewith Robbie
Sch9 is a major target of TORC1 in Saccharomyces cerevisiae.
Molecular cell 2007;26(5):663-74.
2007: McClean Megan N; Mody Areez; Broach James R; Ramanathan Sharad
Cross-talk and decision making in MAP kinase pathways.
Nature genetics 2007;39(3):409-14.
2006: Zawadzki Karl; Broach James
A rapid technique for the visualization of live immobilized yeast cells.
Journal of visualized experiments : JoVE 2006;(1):84.
2006: Guldal Cemile G; Broach James
Assay for adhesion and agar invasion in S. cerevisiae.
Journal of visualized experiments : JoVE 2006;(1):64.
2006: Xu Eugenia Y; Zawadzki Karl A; Broach James R
Single-cell observations reveal intermediate transcriptional silencing states.
Molecular cell 2006;23(2):219-29.
2006: Houston Peter L; Broach James R
The dynamics of homologous pairing during mating type interconversion in budding yeast.
PLoS genetics 2006;2(6):e98.
2006: Ault Addison D; Broach James R
Creation of GPCR-based chemical sensors by directed evolution in yeast.
Protein engineering, design & selection : PEDS 2006;19(1):1-8.
2006: Niida Ayumu; Wang Zixuan; Tomita Kenji; Oishi Shinya; Tamamura Hirokazu; Otaka Akira; Navenot Jean-Marc; Broach James R; Peiper Stephen C; Fujii Nobutaka
Design and synthesis of downsized metastin (45-54) analogs with maintenance of high GPR54 agonistic activity.
Bioorganic & medicinal chemistry letters 2006;16(1):134-7.
2006: Wang Zi-xuan; Broach James R; Peiper Stephen C
Functional expression of CXCR4 in Saccharomyces cerevisiae in the development of powerful tools for the pharmacological characterization of CXCR4.
Methods in molecular biology (Clifton, N.J.) 2006;332():115-27.
2005: Xu Eugenia Y; Bi Xin; Holland Michael J; Gottschling Daniel E; Broach James R
Mutations in the nucleosome core enhance transcriptional silencing.
Molecular and cellular biology 2005;25(5):1846-59.
2004: Schneper Lisa; Düvel Katrin; Broach James R
Sense and sensibility: nutritional response and signal integration in yeast.
Current opinion in microbiology 2004;7(6):624-30.
2004: Broach James R
Making the right choice--long-range chromosomal interactions in development.
Cell 2004;119(5):583-6.
2004: Santhanam Arti; Hartley Alan; Düvel Katrin; Broach James R; Garrett Stephen
PP2A phosphatase activity is required for stress and Tor kinase regulation of yeast stress response factor Msn2p.
Eukaryotic cell 2004;3(5):1261-71.
2004: Jorgensen Paul; Rupes Ivan; Sharom Jeffrey R; Schneper Lisa; Broach James R; Tyers Mike
A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size.
Genes & development 2004;18(20):2491-505.
2004: Wang Ying; Pierce Michael; Schneper Lisa; Güldal C Gökçe; Zhang Xiuying; Tavazoie Saeed; Broach James R
Ras and Gpa2 mediate one branch of a redundant glucose signaling pathway in yeast.
PLoS biology 2004;2(5):E128.
2004: Houston Peter; Simon Peter J; Broach James R
The Saccharomyces cerevisiae recombination enhancer biases recombination during interchromosomal mating-type switching but not in interchromosomal homologous recombination.
Genetics 2004;166(3):1187-97.
2004: Masui Toshihiko; Doi Ryuichiro; Mori Tomohiko; Toyoda Eiji; Koizumi Masayuki; Kami Kazuhiro; Ito Daisuke; Peiper Stephen C; Broach James R; Oishi Shinya; Niida Ayumu; Fujii Nobutaka; Imamura Masayuki
Metastin and its variant forms suppress migration of pancreatic cancer cells.
Biochemical and biophysical research communications 2004;315(1):85-92.
2004: Schneper Lisa; Krauss Alicia; Miyamoto Ryan; Fang Shirley; Broach James R
The Ras/protein kinase A pathway acts in parallel with the Mob2/Cbk1 pathway to effect cell cycle progression and proper bud site selection.
Eukaryotic cell 2004;3(1):108-20.
2004: Zhang W B; Wang Z X; Murray J L; Fujii N; Broach J; Peiper S C
Functional expression of CXCR4 in S. cerevisiae: development of tools for mechanistic and pharmacologic studies.
Ernst Schering Research Foundation workshop 2004;(45):125-52.
2004: Düvel K; Broach J R
The role of phosphatases in TOR signaling in yeast.
Current topics in microbiology and immunology 2004;279():19-38.
2003: Lin Xiaoxia; Floudas Christodoulos A; Wang Ying; Broach James R
Theoretical and computational studies of the glucose signaling pathways in yeast using global gene expression data.
Biotechnology and bioengineering 2003;84(7):864-86.
2003: Arias Diana Alvarez; Navenot Jean-Marc; Zhang Wen-Bo; Broach James; Peiper Stephen C
Constitutive activation of CCR5 and CCR2 induced by conformational changes in the conserved TXP motif in transmembrane helix 2.
The Journal of biological chemistry 2003;278(38):36513-21.
2003: Düvel Katrin; Santhanam Arti; Garrett Stephen; Schneper Lisa; Broach James R
Multiple roles of Tap42 in mediating rapamycin-induced transcriptional changes in yeast.
Molecular cell 2003;11(6):1467-78.
2003: Schedl Paul; Broach James R
Making good neighbors: the right fence for the right job.
Nature structural biology 2003;10(4):241-3.
2003: Yu Qun; Qiu Runxiang; Foland Travis B; Griesen Dan; Galloway Carl S; Chiu Ya-Hui; Sandmeier Joseph; Broach James R; Bi Xin
Rap1p and other transcriptional regulators can function in defining distinct domains of gene expression.
Nucleic acids research 2003;31(4):1224-33.
2002: Zhang Wen-Bo; Navenot Jean-Marc; Haribabu Bodduluri; Tamamura Hirokazu; Hiramatu Kenichi; Omagari Akane; Pei Gang; Manfredi John P; Fujii Nobutaka; Broach James R; Peiper Stephen C
A point mutation that confers constitutive activity to CXCR4 reveals that T140 is an inverse agonist and that AMD3100 and ALX40-4C are weak partial agonists.
The Journal of biological chemistry 2002;277(27):24515-21.
2002: Simon Peter; Houston Peter; Broach James
Directional bias during mating type switching in Saccharomyces is independent of chromosomal architecture.
The EMBO journal 2002;21(9):2282-91.
2001: Haney S A; Xu J; Lee S Y; Ma C L; Duzic E; Broach J R; Manfredi J P
Genetic selection in Saccharomyces of mutant mammalian adenylyl cyclases with elevated basal activities.
Molecular genetics and genomics : MGG 2001;265(6):1120-8.
2001: Bi X; Broach J R
Chromosomal boundaries in S. cerevisiae.
Current opinion in genetics & development 2001;11(2):199-204.
2001: Johnston S D; Enomoto S; Schneper L; McClellan M C; Twu F; Montgomery N D; Haney S A; Broach J R; Berman J
CAC3(MSI1) suppression of RAS2(G19V) is independent of chromatin assembly factor I and mediated by NPR1.
Molecular and cellular biology 2001;21(5):1784-94.
2000: Wu J; Tolstykh T; Lee J; Boyd K; Stock J B; Broach J R
Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo.
The EMBO journal 2000;19(21):5672-81.
1999: Bi X; Braunstein M; Shei G J; Broach J R
The yeast HML I silencer defines a heterochromatin domain boundary by directional establishment of silencing.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(21):11934-9.
1999: Jiang Y; Broach J R
Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast.
The EMBO journal 1999;18(10):2782-92.
1999: Bi X; Broach J R
UASrpg can function as a heterochromatin boundary element in yeast.
Genes & development 1999;13(9):1089-101.
1998: Klein C; Paul J I; Sauvé K; Schmidt M M; Arcangeli L; Ransom J; Trueheart J; Manfredi J P; Broach J R; Murphy A J
Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeast.
Nature biotechnology 1998;16(13):1334-7.
1998: Jiang Y; Davis C; Broach J R
Efficient transition to growth on fermentable carbon sources in Saccharomyces cerevisiae requires signaling through the Ras pathway.
The EMBO journal 1998;17(23):6942-51.
1998: Silverman L; Campbell R; Broach J R
New assay technologies for high-throughput screening.
Current opinion in chemical biology 1998;2(3):397-403.
1998: Epstein C B; Attiyeh E F; Hobson D A; Silver A L; Broach J R; Levine A J
p53 mutations isolated in yeast based on loss of transcription factor activity: similarities and differences from p53 mutations detected in human tumors.
Oncogene 1998;16(16):2115-22.
1997: Bi X; Broach J R
DNA in transcriptionally silent chromatin assumes a distinct topology that is sensitive to cell cycle progression.
Molecular and cellular biology 1997;17(12):7077-87.
1997: Szeto L; Fafalios M K; Zhong H; Vershon A K; Broach J R
Alpha2p controls donor preference during mating type interconversion in yeast by inactivating a recombinational enhancer of chromosome III.
Genes & development 1997;11(15):1899-911.
1997: Holmes S G; Rose A B; Steuerle K; Saez E; Sayegh S; Lee Y M; Broach J R
Hyperactivation of the silencing proteins, Sir2p and Sir3p, causes chromosome loss.
Genetics 1997;145(3):605-14.
1997: Broach J R; Levine A J
Oncogenes and cell proliferation.
Current opinion in genetics & development 1997;7(1):1-6.
1997: Szeto L; Broach J R
Role of alpha2 protein in donor locus selection during mating type interconversion.
Molecular and cellular biology 1997;17(2):751-9.
1996: Braunstein M; Sobel R E; Allis C D; Turner B M; Broach J R
Efficient transcriptional silencing in Saccharomyces cerevisiae requires a heterochromatin histone acetylation pattern.
Molecular and cellular biology 1996;16(8):4349-56.
1996: Holmes S G; Broach J R
Silencers are required for inheritance of the repressed state in yeast.
Genes & development 1996;10(8):1021-32.
1996: Nickels J T; Broach J R
A ceramide-activated protein phosphatase mediates ceramide-induced G1 arrest of Saccharomyces cerevisiae.
Genes & development 1996;10(4):382-94.
1995: Shei G J; Broach J R
Yeast silencers can act as orientation-dependent gene inactivation centers that respond to environmental signals.
Molecular and cellular biology 1995;15(7):3496-506.
1995: Neuman-Silberberg F S; Bhattacharya S; Broach J R
Nutrient availability and the RAS/cyclic AMP pathway both induce expression of ribosomal protein genes in Saccharomyces cerevisiae but by different mechanisms.
Molecular and cellular biology 1995;15(6):3187-96.
1995: Weiler K S; Szeto L; Broach J R
Mutations affecting donor preference during mating type interconversion in Saccharomyces cerevisiae.
Genetics 1995;139(4):1495-510.
1995: Bhattacharya S; Chen L; Broach J R; Powers S
Ras membrane targeting is essential for glucose signaling but not for viability in yeast.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(7):2984-8.
1994: Haney S A; Broach J R
Cdc25p, the guanine nucleotide exchange factor for the Ras proteins of Saccharomyces cerevisiae, promotes exchange by stabilizing Ras in a nucleotide-free state.
The Journal of biological chemistry 1994;269(24):16541-8.
1994: Robinson M K; van Zyl W H; Phizicky E M; Broach J R
TPD1 of Saccharomyces cerevisiae encodes a protein phosphatase 2C-like activity implicated in tRNA splicing and cell separation.
Molecular and cellular biology 1994;14(6):3634-45.
1993: Braunstein M; Rose A B; Holmes S G; Allis C D; Broach J R
Transcriptional silencing in yeast is associated with reduced nucleosome acetylation.
Genes & development 1993;7(4):592-604.
1992: Weiler K S; Broach J R
Donor locus selection during Saccharomyces cerevisiae mating type interconversion responds to distant regulatory signals.
Genetics 1992;132(4):929-42.
1992: van Zyl W; Huang W; Sneddon A A; Stark M; Camier S; Werner M; Marck C; Sentenac A; Broach J R
Inactivation of the protein phosphatase 2A regulatory subunit A results in morphological and transcriptional defects in Saccharomyces cerevisiae.
Molecular and cellular biology 1992;12(11):4946-59.
1991: Broach J R
Ras-regulated signaling processes in Saccharomyces cerevisiae.
Current opinion in genetics & development 1991;1(3):370-7.
1991: Jones S; Vignais M L; Broach J R
The CDC25 protein of Saccharomyces cerevisiae promotes exchange of guanine nucleotides bound to ras.
Molecular and cellular biology 1991;11(5):2641-6.
1991: Mahoney D J; Marquardt R; Shei G J; Rose A B; Broach J R
Mutations in the HML E silencer of Saccharomyces cerevisiae yield metastable inheritance of transcriptional repression.
Genes & development 1991;5(4):605-15.
1990: Greenwald I; Broach J R
Cell fates in C. elegans: in medias ras.
Cell 1990;63(6):1113-6.
1990: Deschenes R J; Resh M D; Broach J R
Acylation and prenylation of proteins.
Current opinion in cell biology 1990;2(6):1108-13.
1990: Fedor-Chaiken M; Deschenes R J; Broach J R
SRV2, a gene required for RAS activation of adenylate cyclase in yeast.
Cell 1990;61(2):329-40.
1990: Broach J R; Deschenes R J
The function of ras genes in Saccharomyces cerevisiae.
Advances in cancer research 1990;54():79-139.
1989: Mahoney D J; Broach J R
The HML mating-type cassette of Saccharomyces cerevisiae is regulated by two separate but functionally equivalent silencers.
Molecular and cellular biology 1989;9(11):4621-30.
1989: van Zyl W H; Wills N; Broach J R
A general screen for mutant of Saccharomyces cerevisiae deficient in tRNA biosynthesis.
Genetics 1989;123(1):55-68.
1989: Volkert F C; Wilson D W; Broach J R
Deoxyribonucleic acid plasmids in yeasts.
Microbiological reviews 1989;53(3):299-317.
1989: Garrett S; Broach J
Loss of Ras activity in Saccharomyces cerevisiae is suppressed by disruptions of a new kinase gene, YAKI, whose product may act downstream of the cAMP-dependent protein kinase.
Genes & development 1989;3(9):1336-48.
1989: Deschenes R J; Stimmel J B; Clarke S; Stock J; Broach J R
RAS2 protein of Saccharomyces cerevisiae is methyl-esterified at its carboxyl terminus.
The Journal of biological chemistry 1989;264(20):11865-73.
1988: Som T; Armstrong K A; Volkert F C; Broach J R
Autoregulation of 2 micron circle gene expression provides a model for maintenance of stable plasmid copy levels.
Cell 1988;52(1):27-37.
1987: Marshall M; Mahoney D; Rose A; Hicks J B; Broach J R
Functional domains of SIR4, a gene required for position effect regulation in Saccharomyces cerevisiae.
Molecular and cellular biology 1987;7(12):4441-52.
1987: Deschenes R J; Broach J R
Fatty acylation is important but not essential for Saccharomyces cerevisiae RAS function.
Molecular and cellular biology 1987;7(7):2344-51.
1986: Volkert F C; Broach J R
Site-specific recombination promotes plasmid amplification in yeast.
Cell 1986;46(4):541-50.
1986: Volkert F C; Wu L C; Fisher P A; Broach J R
Survival strategies of the yeast plasmid two-micron circle.
Basic life sciences 1986;40():375-96.
1984: Feldman J B; Hicks J B; Broach J R
Identification of sites required for repression of a silent mating type locus in yeast.
Journal of molecular biology 1984;178(4):815-34.
1983: Abraham J; Feldman J; Nasmyth K A; Strathern J N; Klar A J; Broach J R; Hicks J B
Sites required for position-effect regulation of mating-type information in yeast.
Cold Spring Harbor symposia on quantitative biology 1983;47 Pt 2():989-98.
1983: Broach J R; Li Y Y; Feldman J; Jayaram M; Abraham J; Nasmyth K A; Hicks J B
Localization and sequence analysis of yeast origins of DNA replication.
Cold Spring Harbor symposia on quantitative biology 1983;47 Pt 2():1165-73.
1980: Broach J R; Hicks J B
Replication and recombination functions associated with the yeast plasmid, 2 mu circle.
Cell 1980;21(2):501-8.

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