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David Broadhurst

Research Profile

Procedures

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Saccharomyces cerevisiae

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Pre-Eclampsia

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Publications

TOP 3
Ä Bartels; J O'Mullane; M Stapleton; David Broadhurst; N Egan; C Joyce; A S Khashan; Keelin O'Donoghue
Maternal serum cholesterol levels are elevated from the 1st trimester of pregnancy: a cross-sectional study.
Warwick B Dunn; Andrew W Nicholls; Ian D Wilson; David Broadhurst
The importance of experimental design and QC samples in large-scale and MS-driven untargeted metabolomic studies of humans.
N Egan; C Joyce; A S Khashan; A Bartels; David Broadhurst; J O'Mullane; Keelin O'Donoghue
Reference standard for serum bile acids in pregnancy.

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All Publications

2012: Ä Bartels; J O'Mullane; M Stapleton; David Broadhurst; N Egan; C Joyce; A S Khashan; Keelin O'Donoghue
Maternal serum cholesterol levels are elevated from the 1st trimester of pregnancy: a cross-sectional study.
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 2012;32(8):747-52.
2012: Warwick B Dunn; Andrew W Nicholls; Ian D Wilson; David Broadhurst
The importance of experimental design and QC samples in large-scale and MS-driven untargeted metabolomic studies of humans.
Bioanalysis 2012;4(18):2249-64.
2012: N Egan; C Joyce; A S Khashan; A Bartels; David Broadhurst; J O'Mullane; Keelin O'Donoghue
Reference standard for serum bile acids in pregnancy.
BJOG : an international journal of obstetrics and gynaecology 2012;119(4):493-8.
2012: Brian H Walsh; David S Wishart; Geraldine B Boylan; David Broadhurst; Louise C Kenny; Rupasri Mandal; Deirdre M Murray
The metabolomic profile of umbilical cord blood in neonatal hypoxic ischaemic encephalopathy.
PloS one 2012;7(12):e50520.
2011: Warwick B Dunn; Sue Francis-McIntyre; Royston Goodacre; Antony Halsall; John N Haselden; Douglas B Kell; Joshau D Knowles; Andrew W Nicholls; Ian D Wilson; Eva Zelena; Nadine Anderson; paul Begley; David Broadhurst; Marie Brown
Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry.
Nature protocols 2011;6(7):1060-83.
2011: Warwick B Dunn; David Broadhurst; Helen J Atherton; Royston Goodacre; Julian L Griffin
Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy.
Chemical Society reviews 2011;40(1):387-426.
2009: Warwick B Dunn; M Brown; S A Worton; Ian P Crocker; David Broadhurst; R Horgan; Louise C Kenny; Philip N Baker; D B Kell; A E P Heazell
Changes in the metabolic footprint of placental explant-conditioned culture medium identifies metabolic disturbances related to hypoxia and pre-eclampsia.
Placenta 2009;30(11):974-80.
2009: paul Begley; Sue Francis-McIntyre; Warwick B Dunn; David Broadhurst; Antony Halsall; Andy Tseng; Joshua Knowles; Royston Goodacre; Douglas B Kell
Development and performance of a gas chromatography-time-of-flight mass spectrometry analysis for large-scale nontargeted metabolomic studies of human serum.
Analytical chemistry 2009;81(16):7038-46.
2009: Kai Ren Ong; Andrew Sims; Michelle Harvie; Mary Chapman; Warwick B Dunn; David Broadhurst; Royston Goodacre; Mary Wilson; Nicola Thomas; Robert B Clarke; Anthony Howell
Biomarkers of dietary energy restriction in women at increased risk of breast cancer.
Cancer prevention research (Philadelphia, Pa.) 2009;2(8):720-31.
2009: Marie Brown; Warwick B Dunn; P Dobson; Y Patel; Catherine L Winder; S Francis-McIntyre; paul Begley; K Carroll; David Broadhurst; A Tseng; N Swainston; Irena Spasic; Royston Goodacre; D B Kell
Mass spectrometry tools and metabolite-specific databases for molecular identification in metabolomics.
The Analyst 2009;134(7):1322-32.
2008: Warwick B Dunn; David Broadhurst; Marie Brown; Philip N Baker; Christopher W G Redman; Louise C Kenny; Douglas B Kell
Metabolic profiling of serum using Ultra Performance Liquid Chromatography and the LTQ-Orbitrap mass spectrometry system.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;871(2):288-98.
2008: Louise C Kenny; David Broadhurst; Marie Brown; Warwick B Dunn; Christopher W G Redman; Douglas B Kell; Philip N Baker
Detection and identification of novel metabolomic biomarkers in preeclampsia.
Reproductive sciences (Thousand Oaks, Calif.) 2008;15(6):591-7.
2008: Catherine L Winder; Warwick B Dunn; Stephanie Schuler; David Broadhurst; Roger M Jarvis; Gill Stephens; Royston Goodacre
Global metabolic profiling of Escherichia coli cultures: an evaluation of methods for quenching and extraction of intracellular metabolites.
Analytical chemistry 2008;80(8):2939-48.
2008: Warwick B Dunn; David Broadhurst; David I Ellis; Marie Brown; Anthony Halsall; Steve O'Hagan; Irena Spasic; Andrew Tseng; Douglas B Kell
A GC-TOF-MS study of the stability of serum and urine metabolomes during the UK Biobank sample collection and preparation protocols.
International journal of epidemiology 2008;37 Suppl 1():i23-30.
2007: Steve O'Hagan; Warwick B Dunn; Joshua D Knowles; David Broadhurst; Rebecca Williams; Jason J Ashworth; Maureen Cameron; Douglas B Kell
Closed-loop, multiobjective optimization of two-dimensional gas chromatography/mass spectrometry for serum metabolomics.
Analytical chemistry 2007;79(2):464-76.
2007: Juan I Castrillo; Leo A H Zeef; David C Hoyle; Nianshu Zhang; Andrew Hayes; David Cj Gardner; Michael Cornell; June Petty; Luke Hakes; Leanne Wardleworth; Bharat Rash; Marie Brown; Warwick B Dunn; David Broadhurst; Kerry O'Donoghue; Svenja S Hester; Tom P J Dunkley; Sarah Hart; Neil Swainston; Peter Li; Simon J Gaskell; Norman W Paton; Kathryn S Lilley; Douglas B Kell; Stephen G Oliver
Growth control of the eukaryote cell: a systems biology study in yeast.
Journal of biology 2007;6(2):4.
2006: Roger M Jarvis; David Broadhurst; Helen Johnson; Noel M O'Boyle; Royston Goodacre
PYCHEM: a multivariate analysis package for python.
Bioinformatics (Oxford, England) 2006;22(20):2565-6.
2006: Benjamin R Underwood; David Broadhurst; Warwick B Dunn; David I Ellis; Andrew W Michell; Coralie Vacher; David Mosedale; Douglas B Kell; Roger A Barker; David J Grainger; David C Rubinsztein
Huntington disease patients and transgenic mice have similar pro-catabolic serum metabolite profiles.
Brain : a journal of neurology 2006;129(Pt 4):877-86.
2005: David I Ellis; David Broadhurst; Sarah J Clarke; Royston Goodacre
Rapid identification of closely related muscle foods by vibrational spectroscopy and machine learning.
The Analyst 2005;130(12):1648-54.
2004: Jess Allen; Hazel Davey; David Broadhurst; Jem J Rowland; Stephen G Oliver; Douglas B Kell
Discrimination of modes of action of antifungal substances by use of metabolic footprinting.
Applied and environmental microbiology 2004;70(10):6157-65.
2004: Helen E Johnson; David Broadhurst; Douglas B Kell; Michael K Theodorou; Roger J Merry; Gareth W Griffith
High-throughput metabolic fingerprinting of legume silage fermentations via Fourier transform infrared spectroscopy and chemometrics.
Applied and environmental microbiology 2004;70(3):1583-92.
2003: Seetharaman Vaidyanathan; David Broadhurst; Douglas B Kell; Royston Goodacre
Explanatory optimization of protein mass spectrometry via genetic search.
Analytical chemistry 2003;75(23):6679-86.
2003: Jess Allen; Hazel Davey; David Broadhurst; Jim K Heald; Jem J Rowland; Stephen G Oliver; Douglas B Kell
High-throughput classification of yeast mutants for functional genomics using metabolic footprinting.
Nature biotechnology 2003;21(6):692-6.
2003: Helen E Johnson; David Broadhurst; Royston Goodacre; Aileen R Smith
Metabolic fingerprinting of salt-stressed tomatoes.
Phytochemistry 2003;62(6):919-28.
2002: Aoife C McGovern; David Broadhurst; Janet Taylor; Naheed N Kaderbhai; Michael K Winson; David A Small; Jem J Rowland; Douglas B Kell; Royston Goodacre
Monitoring of complex industrial bioprocesses for metabolite concentrations using modern spectroscopies and machine learning: application to gibberellic acid production.
Biotechnology and bioengineering 2002;78(5):527-38.
2002: David I Ellis; David Broadhurst; Douglas B Kell; Jem J Rowland; Royston Goodacre
Rapid and quantitative detection of the microbial spoilage of meat by fourier transform infrared spectroscopy and machine learning.
Applied and environmental microbiology 2002;68(6):2822-8.
2001: Léonie M Raamsdonk; Bas Teusink; David Broadhurst; N Zhang; Andrew Hayes; Michael C Walsh; Jan A Berden; K M Brindle; D B Kell; Jem J Rowland; Hans V Westerhoff; Karel van Dam; Stephen G Oliver
A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations.
Nature biotechnology 2001;19(1):45-50.
2000: AD Shaw; Michael K Winson; Andrew M Woodward; Aoife C McGovern; Hazel Davey; Naheed N Kaderbhai; David Broadhurst; Richard James Gilbert; Janet Taylor; EM Timmins; Royston Goodacre; D B Kell; BK Alsberg; Jem J Rowland
Rapid analysis of high-dimensional bioprocesses using multivariate spectroscopies and advanced chemometrics.
Advances in biochemical engineering/biotechnology 2000;66():83-113.