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Arthur Broadus

Research Profile

Chemicals & Drugs

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Hypercalcemia

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TOP 3
Meina Wang; Randy L Johnson; Ali R Nasiri; Joshua N VanHouten; Arthur E Broadus
PTHrP regulates the modeling of cortical bone surfaces at fibrous insertion sites during growth.
Carolyn M Macica; Ali Nasiri; Guoying Liang; Arthur E Broadus
Genetic evidence of the regulatory role of parathyroid hormone-related protein in articular chondrocyte maintenance in an experimental mouse model.
Xuesong Chen; Carolyn M Macica; Ali Nasiri; Arthur E Broadus
Regulation of articular chondrocyte proliferation and differentiation by indian hedgehog and parathyroid hormone-related protein in mice.

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All Publications

2013: Meina Wang; Randy L Johnson; Ali R Nasiri; Joshua N VanHouten; Arthur E Broadus
PTHrP regulates the modeling of cortical bone surfaces at fibrous insertion sites during growth.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013;28(3):598-607.
2011: Carolyn M Macica; Ali Nasiri; Guoying Liang; Arthur E Broadus
Genetic evidence of the regulatory role of parathyroid hormone-related protein in articular chondrocyte maintenance in an experimental mouse model.
Arthritis and rheumatism 2011;63(11):3333-43.
2008: Xuesong Chen; Carolyn M Macica; Ali Nasiri; Arthur E Broadus
Regulation of articular chondrocyte proliferation and differentiation by indian hedgehog and parathyroid hormone-related protein in mice.
Arthritis and rheumatism 2008;58(12):3788-97.
2007: Arthur E Broadus; Carolyn M Macica; Xuesong Chen
The PTHrP functional domain is at the gates of endochondral bones.
Annals of the New York Academy of Sciences 2007;1116():65-81.
2007: Xuesong Chen; Carolyn M Macica; Ali Nasiri; Stefan Judex; Arthur E Broadus
Mechanical regulation of PTHrP expression in entheses.
Bone 2007;41(5):752-9.
2006: Carolyn M Macica; Guoying Liang; Karen L Lankford; Arthur E Broadus
Induction of parathyroid hormone-related peptide following peripheral nerve injury: role as a modulator of Schwann cell phenotype.
Glia 2006;53(6):637-48.
2006: Xuesong Chen; Carolyn M Macica; Barbara E Dreyer; Vicki E Hammond; Julie R Hens; William M Philbrick; Arthur E Broadus
Initial characterization of PTH-related protein gene-driven lacZ expression in the mouse.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006;21(1):113-23.
2005: Xuesong Chen; Carolyn M Macica; Kong Wah Ng; Arthur E Broadus
Stretch-induced PTH-related protein gene expression in osteoblasts.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2005;20(8):1454-61.
2003: Carolyn M Macica; Arthur E Broadus
PTHrP regulates cerebral blood flow and is neuroprotective.
American journal of physiology. Regulatory, integrative and comparative physiology 2003;284(4):R1019-20.
2002: Oindrila Chatterjee; Inaam A Nakchbandi; William M Philbrick; Barbara E Dreyer; Jian-Ping Zhang; Leonard K Kaczmarek; Michael Brines; Arthur E Broadus
Endogenous parathyroid hormone-related protein functions as a neuroprotective agent.
Brain research 2002;930(1-2):58-66.
2002: Arthur E Broadus; Kristina M Braaten
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 7-2002. A 47-year-old woman with late recurrent hyperparathyroidism.
The New England journal of medicine 2002;346(9):694-700.
2000: Inaam A Nakchbandi; E E Weir; Karl Insogna; William M Philbrick; Arthur E Broadus
Parathyroid hormone-related protein induces spontaneous osteoclast formation via a paracrine cascade.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(13):7296-300.
1999: Michael Brines; Z Ling; Arthur E Broadus
Parathyroid hormone-related protein protects against kainic acid excitotoxicity in rat cerebellar granule cells by regulating L-type channel calcium flux.
Neuroscience letters 1999;274(1):13-6.
1999: Michael Brines; Arthur E Broadus
Parathyroid hormone-related protein markedly potentiates depolarization-induced catecholamine release in PC12 cells via L-type voltage-sensitive Ca2+ channels.
Endocrinology 1999;140(2):646-51.
1998: John Foley; B J Longely; John J Wysolmerski; Barbara E Dreyer; Arthur E Broadus; William M Philbrick
PTHrP regulates epidermal differentiation in adult mice.
The Journal of investigative dermatology 1998;111(6):1122-8.
1998: John J Wysolmerski; William M Philbrick; Maureen E Dunbar; Beate Lanske; Henry M Kronenberg; Arthur E Broadus
Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development.
Development (Cambridge, England) 1998;125(7):1285-94.
1997: Michael Amling; Lynn Neff; Sakae Tanaka; D Inoue; Keisuke Kuida; E Weir; William M Philbrick; Arthur E Broadus; Roland Baron
Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development.
The Journal of cell biology 1997;136(1):205-13.
1996: Maureen E Dunbar; John J Wysolmerski; Arthur E Broadus
Parathyroid hormone-related protein: from hypercalcemia of malignancy to developmental regulatory molecule.
The American journal of the medical sciences 1996;312(6):287-94.
1996: E H Holt; Arthur E Broadus; Michael Brines
Parathyroid hormone-related peptide is produced by cultured cerebellar granule cells in response to L-type voltage-sensitive Ca2+ channel flux via a Ca2+/calmodulin-dependent kinase pathway.
The Journal of biological chemistry 1996;271(45):28105-11.
1996: E C Weir; William M Philbrick; Michael Amling; Lynn Neff; Roland Baron; Arthur E Broadus
Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(19):10240-5.
1996: John Foley; John J Wysolmerski; Arthur E Broadus; William M Philbrick
Parathyroid hormone-related protein gene expression in human squamous carcinoma cells is repressed by mutant isoforms of p53.
Cancer research 1996;56(17):4056-62.
1996: John J Wysolmerski; Rupangi C Vasavada; John Foley; E C Weir; W J Burtis; Subhash C. Kukreja; T A Guise; Arthur E Broadus; William M Philbrick
Transactivation of the PTHrP gene in squamous carcinomas predicts the occurrence of hypercalcemia in athymic mice.
Cancer research 1996;56(5):1043-9.
1996: William M Philbrick; John J Wysolmerski; S Galbraith; E Holt; J J Orloff; K H Yang; Rupangi C Vasavada; E C Weir; Arthur E Broadus; Andrew F Stewart
Defining the roles of parathyroid hormone-related protein in normal physiology.
Physiological reviews 1996;76(1):127-73.
1995: John J Wysolmerski; J F McCaughern-Carucci; A G Daifotis; Arthur E Broadus; William M Philbrick
Overexpression of parathyroid hormone-related protein or parathyroid hormone in transgenic mice impairs branching morphogenesis during mammary gland development.
Development (Cambridge, England) 1995;121(11):3539-47.
1995: L L Plawner; William M Philbrick; W J Burtis; Arthur E Broadus; Andrew F Stewart
Cell type-specific secretion of parathyroid hormone-related protein via the regulated versus the constitutive secretory pathway.
The Journal of biological chemistry 1995;270(23):14078-84.
1994: W J Burtis; L Gay; Karl Insogna; A Ellison; Arthur E Broadus
Dietary hypercalciuria in patients with calcium oxalate kidney stones.
The American journal of clinical nutrition 1994;60(3):424-9.
1994: K H Yang; A E dePapp; N E Soifer; Barbara E Dreyer; T L Wu; S E Porter; M Bellantoni; W J Burtis; Karl Insogna; Arthur E Broadus
Parathyroid hormone-related protein: evidence for isoform- and tissue-specific posttranslational processing.
Biochemistry 1994;33(23):7460-9.
1994: E H Holt; C Lu; Barbara E Dreyer; Priscilla S Dannies; Arthur E Broadus
Regulation of parathyroid hormone-related peptide gene expression by estrogen in GH4C1 rat pituitary cells has the pattern of a primary response gene.
Journal of neurochemistry 1994;62(4):1239-46.
1994: John J Wysolmerski; Arthur E Broadus; J Zhou; E Fuchs; Leonard M Milstone; William M Philbrick
Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(3):1133-7.
1994: John J Wysolmerski; Arthur E Broadus
Hypercalcemia of malignancy: the central role of parathyroid hormone-related protein.
Annual review of medicine 1994;45():189-200.
1993: E H Holt; Rupangi C Vasavada; N H Bander; Arthur E Broadus; William M Philbrick
Region-specific methylation of the parathyroid hormone-related peptide gene determines its expression in human renal carcinoma cell lines.
The Journal of biological chemistry 1993;268(27):20639-45.
1993: Rupangi C Vasavada; John J Wysolmerski; Arthur E Broadus; William M Philbrick
Identification and characterization of a GC-rich promoter of the human parathyroid hormone-related peptide gene.
Molecular endocrinology (Baltimore, Md.) 1993;7(2):273-82.
1992: A G Daifotis; E C Weir; Barbara E Dreyer; Arthur E Broadus
Stretch-induced parathyroid hormone-related peptide gene expression in the rat uterus.
The Journal of biological chemistry 1992;267(33):23455-8.
1992: N E Soifer; K E Dee; Karl Insogna; W J Burtis; L M Matovcik; T L Wu; Leonard M Milstone; Arthur E Broadus; William M Philbrick; Andrew F Stewart
Parathyroid hormone-related protein. Evidence for secretion of a novel mid-region fragment by three different cell types.
The Journal of biological chemistry 1992;267(25):18236-43.
1990: Andrew F Stewart; Arthur E Broadus
Clinical review 16: Parathyroid hormone-related proteins: coming of age in the 1990s.
The Journal of clinical endocrinology and metabolism 1990;71(6):1410-4.
1990: M Mangin; K Ikeda; Arthur E Broadus
Structure of the mouse gene encoding parathyroid hormone-related peptide.
Gene 1990;95(2):195-202.
1990: M A Thiede; A G Daifotis; E C Weir; Michael Brines; W J Burtis; K Ikeda; Barbara E Dreyer; Robert E Garfield; Arthur E Broadus
Intrauterine occupancy controls expression of the parathyroid hormone-related peptide gene in preterm rat myometrium.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(18):6969-73.
1990: M Mangin; K Ikeda; Barbara E Dreyer; Arthur E Broadus
Identification of an up-stream promoter of the human parathyroid hormone-related peptide gene.
Molecular endocrinology (Baltimore, Md.) 1990;4(6):851-8.
1990: W J Burtis; T G Brady; J J Orloff; J B Ersbak; R P Warrell; B R Olson; T L Wu; MaryAnn E Mitnick; Arthur E Broadus; Andrew F Stewart
Immunochemical characterization of circulating parathyroid hormone-related protein in patients with humoral hypercalcemia of cancer.
The New England journal of medicine 1990;322(16):1106-12.
1990: K Ikeda; C Lu; E C Weir; M Mangin; Arthur E Broadus
Regulation of parathyroid hormone-related peptide gene expression by cycloheximide.
The Journal of biological chemistry 1990;265(10):5398-402.
1990: E C Weir; Michael Brines; K Ikeda; W J Burtis; Arthur E Broadus; R J Robbins
Parathyroid hormone-related peptide gene is expressed in the mammalian central nervous system.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(1):108-12.
1989: C Lu; K Ikeda; L J Deftos; A F Gazdar; M Mangin; Arthur E Broadus
Glucocorticoid regulation of parathyroid hormone-related peptide gene transcription in a human neuroendocrine cell line.
Molecular endocrinology (Baltimore, Md.) 1989;3(12):2034-40.
1989: K Ikeda; A Arnold; M Mangin; Barbara K Kinder; N A Vydelingum; Murray F Brennan; Arthur E Broadus
Expression of transcripts encoding a parathyroid hormone-related peptide in abnormal human parathyroid tissues.
The Journal of clinical endocrinology and metabolism 1989;69(6):1240-8.
1989: K Ikeda; C Lu; E C Weir; M Mangin; Arthur E Broadus
Transcriptional regulation of the parathyroid hormone-related peptide gene by glucocorticoids and vitamin D in a human C-cell line.
The Journal of biological chemistry 1989;264(27):15743-6.
1989: K Ikeda; E C Weir; Kazuyasu Sakaguchi; W J Burtis; M Zimering; M Mangin; Barbara E Dreyer; Maria Luisa Brandi; G D Aurbach; Arthur E Broadus
Clonal rat parathyroid cell line expresses a parathyroid hormone-related peptide but not parathyroid hormone itself.
Biochemical and biophysical research communications 1989;162(1):108-15.
1989: K Ikeda; J T Posillico; M B Boyle; A C Webb; Edward M Brown; Arthur E Broadus
Microinjected Xenopus oocytes secrete mature, biologically active parathyroid hormone.
Molecular endocrinology (Baltimore, Md.) 1989;3(7):1084-9.
1989: M Mangin; K Ikeda; Barbara E Dreyer; Arthur E Broadus
Isolation and characterization of the human parathyroid hormone-like peptide gene.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(7):2408-12.
1989: Arthur E Broadus
Primary hyperparathyroidism.
The Journal of urology 1989;141(3 Pt 2):723-30.
1989: Karl Insogna; A S Ellison; W J Burtis; L Sartori; R L Lang; Arthur E Broadus
Trichlormethiazide and oral phosphate therapy in patients with absorptive hypercalciuria.
The Journal of urology 1989;141(2):269-74.
1988: K Ikeda; E C Weir; M Mangin; Priscilla S Dannies; Barbara K Kinder; L J Deftos; Edward M Brown; Arthur E Broadus
Expression of messenger ribonucleic acids encoding a parathyroid hormone-like peptide in normal human and animal tissues with abnormal expression in human parathyroid adenomas.
Molecular endocrinology (Baltimore, Md.) 1988;2(12):1230-6.
1988: M Mangin; K Ikeda; Barbara E Dreyer; Leonard M Milstone; Arthur E Broadus
Two distinct tumor-derived, parathyroid hormone-like peptides result from alternative ribonucleic acid splicing.
Molecular endocrinology (Baltimore, Md.) 1988;2(11):1049-55.
1988: Arthur E Broadus; M Mangin; K Ikeda; Karl Insogna; E C Weir; W J Burtis; Andrew F Stewart
Humoral hypercalcemia of cancer. Identification of a novel parathyroid hormone-like peptide.
The New England journal of medicine 1988;319(9):556-63.
1988: K Ikeda; M Mangin; Barbara E Dreyer; A C Webb; J T Posillico; Andrew F Stewart; N H Bander; E C Weir; Karl Insogna; Arthur E Broadus
Identification of transcripts encoding a parathyroid hormone-like peptide in messenger RNAs from a variety of human and animal tumors associated with humoral hypercalcemia of malignancy.
The Journal of clinical investigation 1988;81(6):2010-4.
1988: W A Petit; J Henrich; Karl Insogna; MaryAnn E Mitnick; Arthur E Broadus
Influence of furosemide on parathyroid hormone levels in hyperparathyroidism.
The New England journal of medicine 1988;318(10):644-5.
1988: E C Weir; Karl Insogna; D G Brownstein; N H Bander; Arthur E Broadus
In vitro adenylate cyclase-stimulating activity predicts the occurrence of humoral hypercalcemia of malignancy in nude mice.
The Journal of clinical investigation 1988;81(3):818-21.
1988: Andrew F Stewart; M Mangin; T Wu; D Goumas; Karl Insogna; W J Burtis; Arthur E Broadus
Synthetic human parathyroid hormone-like protein stimulates bone resorption and causes hypercalcemia in rats.
The Journal of clinical investigation 1988;81(2):596-600.
1988: L Sartori; E C Weir; Andrew F Stewart; Arthur E Broadus; M Mangin; Paula Q Barrett; Karl Insogna
Synthetic and partially-purified adenylate cyclase-stimulating proteins from tumors associated with humoral hypercalcemia of malignancy inhibit phosphate transport in a PTH-responsive renal cell line.
The Journal of clinical endocrinology and metabolism 1988;66(2):459-61.
1988: E C Weir; R W Norrdin; R E Matus; M B Brooks; Arthur E Broadus; Mary Ann Mitnick; S D Johnston; Karl Insogna
Humoral hypercalcemia of malignancy in canine lymphosarcoma.
Endocrinology 1988;122(2):602-8.
1988: Karl Insogna; Barbara E Dreyer; Mary Ann Mitnick; A F Ellison; Arthur E Broadus
Enhanced production rate of 1,25-dihydroxyvitamin D in sarcoidosis.
The Journal of clinical endocrinology and metabolism 1988;66(1):72-5.
1987: Andrew F Stewart; W J Burtis; T Wu; D Goumas; Arthur E Broadus
Two forms of parathyroid hormone-like adenylate cyclase-stimulating protein derived from tumors associated with humoral hypercalcemia of malignancy.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1987;2(6):587-93.
1987: Andrew F Stewart; T Wu; D Goumas; W J Burtis; Arthur E Broadus
N-terminal amino acid sequence of two novel tumor-derived adenylate cyclase-stimulating proteins: identification of parathyroid hormone-like and parathyroid hormone-unlike domains.
Biochemical and biophysical research communications 1987;146(2):672-8.
1987: W J Burtis; T Wu; C Bunch; John J Wysolmerski; K L Insogna; E C Weir; Arthur E Broadus; Andrew F Stewart
Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy.
The Journal of biological chemistry 1987;262(15):7151-6.
1987: A F Stewart; T Wu; W J Burtis; E C Weir; Arthur E Broadus; Karl Insogna
The relative potency of a human tumor-derived PTH-like adenylate cyclase-stimulating preparation in three bioassays.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1987;2(1):37-43.
1987: Arthur E Broadus; W J Burtis; D A Oren; L Sartori; L Gay; A F Ellison; Karl Insogna
Concerning the pathogenesis of idiopathic hypercalciuria.
Contributions to nephrology 1987;58():127-36.
1985: Karl Insogna; MaryAnn E Mitnick; Andrew F Stewart; W J Burtis; L E Mallette; Arthur E Broadus
Sensitivity of the parathyroid hormone-1,25-dihydroxyvitamin D axis to variations in calcium intake in patients with primary hyperparathyroidism.
The New England journal of medicine 1985;313(18):1126-30.
1985: Karl Insogna; Arthur E Broadus; Barbara E Dreyer; A F Ellison; J M Gertner
Elevated production rate of 1,25-dihydroxyvitamin D in patients with absorptive hypercalciuria.
The Journal of clinical endocrinology and metabolism 1985;61(3):490-5.
1984: Arthur E Broadus; Karl Insogna; R Lang; A F Ellison; Barbara E Dreyer
Evidence for disordered control of 1,25-dihydroxyvitamin D production in absorptive hypercalciuria.
The New England journal of medicine 1984;311(2):73-80.
1984: Arthur E Broadus; Karl Insogna; R Lang; L E Mallette; D A Oren; J M Gertner; A S Kliger; A F Ellison
A consideration of the hormonal basis and phosphate leak hypothesis of absorptive hypercalciuria.
The Journal of clinical endocrinology and metabolism 1984;58(1):161-9.