Yasunobu Yoshikai

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Takeuchi Ario; Kamiryou Yoriyuki; Yamada Hisakata; Eto Masatoshi; Shibata Kensuke; Haruna Kennichi; Naito Seiji; Yoshikai Yasunobu
Oral administration of xanthan gum enhances antitumor activity through Toll-like receptor 4.
Onzuka T; Tomita Y; Shimizu I; Okano S; Yamada H; Yoshikai Y; Tominaga R
Effects of lipopolysaccharide on the induction of mixed chimerism in cyclophosphamide-induced tolerance.
Ishikawa Takahiro; Yamada Hisakata; Oyamada Akiko; Goshima Fumi; Nishiyama Yukihiro; Yoshikai Yasunobu
Protective role of Fas-FasL signaling in lethal infection with herpes simplex virus type 2 in mice.

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2009: Takeuchi Ario; Kamiryou Yoriyuki; Yamada Hisakata; Eto Masatoshi; Shibata Kensuke; Haruna Kennichi; Naito Seiji; Yoshikai Yasunobu
Oral administration of xanthan gum enhances antitumor activity through Toll-like receptor 4.
International immunopharmacology 2009;9(13-14):1562-7.
2009: Onzuka T; Tomita Y; Shimizu I; Okano S; Yamada H; Yoshikai Y; Tominaga R
Effects of lipopolysaccharide on the induction of mixed chimerism in cyclophosphamide-induced tolerance.
Scandinavian journal of immunology 2009;70(5):423-30.
2009: Ishikawa Takahiro; Yamada Hisakata; Oyamada Akiko; Goshima Fumi; Nishiyama Yukihiro; Yoshikai Yasunobu
Protective role of Fas-FasL signaling in lethal infection with herpes simplex virus type 2 in mice.
Journal of virology 2009;83(22):11777-83.
2009: Maeda Naoyoshi; Nakamura Risa; Hirose Yoshitaka; Murosaki Shinji; Yamamoto Yoshihiro; Kase Tetsuo; Yoshikai Yasunobu
Oral administration of heat-killed Lactobacillus plantarum L-137 enhances protection against influenza virus infection by stimulation of type I interferon production in mice.
International immunopharmacology 2009;9(9):1122-5.
2009: Itsumi Momoe; Yoshikai Yasunobu; Yamada Hisakata
IL-15 is critical for the maintenance and innate functions of self-specific CD8(+) T cells.
European journal of immunology 2009;39(7):1784-93.
2009: Tang Ce; Yamada Hisakata; Shibata Kensuke; Yoshida Shin-ichi; Wajjwalku Worawidh; Yoshikai Yasunobu
IL-15 protects antigen-specific CD8+ T cell contraction after Mycobacterium bovis bacillus Calmette-Guérin infection.
Journal of leukocyte biology 2009;86(1):187-94.
2009: Kamiryo Yoriyuki; Eto Masatoshi; Yamada Hisakata; Yajima Toshiki; Harano Masahiko; Takeuchi Ario; Tatsugami Katsunori; Hamaguchi Masumitsu; Naito Seiji; Yoshikai Yasunobu
Donor CD4 T cells are critical in allogeneic stem cell transplantation against murine solid tumor.
Cancer research 2009;69(12):5151-8.
2009: Shinozaki Yukari; Wang Sen; Miyazaki Yoshiyuki; Miyazaki Kohji; Yamada Hisakata; Yoshikai Yasunobu; Hara Hiromitsu; Yoshida Hiroki
Tumor-specific cytotoxic T cell generation and dendritic cell function are differentially regulated by interleukin 27 during development of anti-tumor immunity.
International journal of cancer. Journal international du cancer 2009;124(6):1372-8.
2009: Hamaguchi Masumitsu; Eto Masatoshi; Kamiryo Yoriyuki; Takeuchi Ario; Harano Masahiko; Tatsugami Katsunori; Teshima Takanori; Harada Mamoru; Yoshikai Yasunobu; Naito Seiji
Allogeneic cell therapy from immunized donors with tumor antigen peptide enhances the antitumor effect after cyclophosphamide-using non-myeloablative allogeneic hematopoietic cell transplantation.
Cancer science 2009;100(1):138-43.
2008: Saiga Hiroyuki; Nishimura Junichi; Kuwata Hirotaka; Okuyama Megumi; Matsumoto Sohkichi; Sato Shintaro; Matsumoto Makoto; Akira Shizuo; Yoshikai Yasunobu; Honda Kenya; Yamamoto Masahiro; Takeda Kiyoshi
Lipocalin 2-dependent inhibition of mycobacterial growth in alveolar epithelium.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(12):8521-7.
2008: Onzuka Tatsushi; Tomita Yukihiro; Shimizu Ichiro; Okano Shinji; Yamada Hisakata; Yoshikai Yasunobu; Tominaga Ryuji
Role of the cytokine profiles produced by invariant natural killer T cells in the initial phase of cyclophosphamide-induced tolerance.
Transplantation 2008;86(9):1301-10.
2008: Tang Ce; Yamada Hisakata; Shibata Kensuke; Muta Hiromi; Wajjwalku Worawidh; Podack Eckhard R; Yoshikai Yasunobu
A novel role of CD30L/CD30 signaling by T-T cell interaction in Th1 response against mycobacterial infection.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(9):6316-27.
2008: Mousavi Seyed Fazlollah; Soroosh Pejman; Takahashi Takeshi; Yoshikai Yasunobu; Shen Hao; Lefrançois Leo; Borst Jannie; Sugamura Kazuo; Ishii Naoto
OX40 costimulatory signals potentiate the memory commitment of effector CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(9):5990-6001.
2008: Shibata Kensuke; Yamada Hisakata; Nakamura Risa; Sun Xun; Itsumi Momoe; Yoshikai Yasunobu
Identification of CD25+ gamma delta T cells as fetal thymus-derived naturally occurring IL-17 producers.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(9):5940-7.
2008: Maeda Naoyoshi; Fan Hung; Yoshikai Yasunobu
Oncogenesis by retroviruses: old and new paradigms.
Reviews in medical virology 2008;18(6):387-405.
2008: Hikosaka Yu; Nitta Takeshi; Ohigashi Izumi; Yano Kouta; Ishimaru Naozumi; Hayashi Yoshio; Matsumoto Mitsuru; Matsuo Koichi; Penninger Josef M; Takayanagi Hiroshi; Yokota Yoshifumi; Yamada Hisakata; Yoshikai Yasunobu; Inoue Jun-Ichiro; Akiyama Taishin; Takahama Yousuke
The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.
Immunity 2008;29(3):438-50.
2008: Yamada H; Nakashima Y; Okazaki K; Mawatari T; Fukushi J-I; Kaibara N; Hori A; Iwamoto Y; Yoshikai Y
Th1 but not Th17 cells predominate in the joints of patients with rheumatoid arthritis.
Annals of the rheumatic diseases 2008;67(9):1299-304.
2008: Nakamura Risa; Shibata Kensuke; Yamada Hisakata; Shimoda Kazuya; Nakayama Keiichi; Yoshikai Yasunobu
Tyk2-signaling plays an important role in host defense against Escherichia coli through IL-23-induced IL-17 production by gammadelta T cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(3):2071-5.
2008: Eto Masatoshi; Kamiryo Yoriyuki; Takeuchi Ario; Harano Masahiko; Tatsugami Katsunori; Harada Mamoru; Kiyoshima Keijiro; Hamaguchi Masumitsu; Teshima Takanori; Tsuneyoshi Masazumi; Yoshikai Yasunobu; Naito Seiji
Posttransplant administration of cyclophosphamide and donor lymphocyte infusion induces potent antitumor immunity to solid tumor.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(9):2833-40.
2008: Tang Ce; Yamada Hisakata; Shibata Kensuke; Maeda Naoyoshi; Yoshida Shinichi; Wajjwalku Worawidh; Ohara Naoya; Yamada Takeshi; Kinoshita Taroh; Yoshikai Yasunobu
Efficacy of recombinant bacille Calmette-Guérin vaccine secreting interleukin-15/antigen 85B fusion protein in providing protection against Mycobacterium tuberculosis.
The Journal of infectious diseases 2008;197(9):1263-74.
2008: Nishimura Junichi; Saiga Hiroyuki; Sato Shintaro; Okuyama Megumi; Kayama Hisako; Kuwata Hirotaka; Matsumoto Sohkichi; Nishida Toshirou; Sawa Yoshiki; Akira Shizuo; Yoshikai Yasunobu; Yamamoto Masahiro; Takeda Kiyoshi
Potent antimycobacterial activity of mouse secretory leukocyte protease inhibitor.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(6):4032-9.
2008: Sun Xun; Somada Shinichi; Shibata Kensuke; Muta Hiromi; Yamada Hisakata; Yoshihara Hirofumi; Honda Kuniomi; Nakamura Kazuhiko; Takayanagi Ryhoichi; Tani Kenzaburo; Podack Eckhard R; Yoshikai Yasunobu
A critical role of CD30 ligand/CD30 in controlling inflammatory bowel diseases in mice.
Gastroenterology 2008;134(2):447-58.
2008: Kagimoto Yoshiko; Yamada Hisakata; Ishikawa Takahiro; Maeda Naoyoshi; Goshima Fumi; Nishiyama Yukihiro; Furue Masutaka; Yoshikai Yasunobu
A regulatory role of interleukin 15 in wound healing and mucosal infection in mice.
Journal of leukocyte biology 2008;83(1):165-72.
2007: Maeda Naoyoshi; Yoshikai Yasunobu
[New molecular mechanisms of virus-mediated carcinogenesis: oncogenic transformation of cells by retroviral structural protein Envelope]
Uirusu. Journal of virology 2007;57(2):159-70.
2007: Iwai Toshiro; Tomita Yukihiro; Shimizu Ichiro; Kajiwara Takashi; Onzuka Tatsushi; Okano Shinji; Yasunami Yohichi; Yoshikai Yasunobu; Nomoto Kikuo; Tominaga Ryuji
The immunoregulatory roles of natural killer T cells in cyclophosphamide-induced tolerance.
Transplantation 2007;84(12):1686-95.
2007: Yoshihara Kazufumi; Yamada Hisakata; Hori Akiko; Yajima Toshiki; Kubo Chiharu; Yoshikai Yasunobu
IL-15 exacerbates collagen-induced arthritis with an enhanced CD4+ T cell response to produce IL-17.
European journal of immunology 2007;37(10):2744-52.
2007: Chiba Norika; Masuda Akio; Yoshikai Yasunobu; Matsuguchi Tetsuya
Ceramide inhibits LPS-induced production of IL-5, IL-10, and IL-13 from mast cells.
Journal of cellular physiology 2007;213(1):126-36.
2007: Sun Xun; Yamada Hisakata; Yoshihara Kazufumi; Awaya Akira; Yoshikai Yasunobu
In vivo treatment with a nonapeptide thymic hormone, facteur thymique serique (FTS), ameliorates chronic colitis induced by dextran sulphate sodium in mice.
International immunopharmacology 2007;7(7):928-36.
2007: Li Wei; Yamada Hisakata; Yajima Toshiki; Nakagawa Ryusuke; Shimoda Kazuya; Nakayama Keiichi; Yoshikai Yasunobu
Tyk2 signaling in host environment plays an important role in contraction of antigen-specific CD8+ T cells following a microbial infection.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(7):4482-8.
2007: Shibata Kensuke; Yamada Hisakata; Hara Hiromitsu; Kishihara Kenji; Yoshikai Yasunobu
Resident Vdelta1+ gammadelta T cells control early infiltration of neutrophils after Escherichia coli infection via IL-17 production.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(7):4466-72.
2007: Doi Takehiko; Yamada Hisakata; Yajima Toshiki; Wajjwalku Worawidh; Hara Toshiro; Yoshikai Yasunobu
H2-M3-restricted CD8+ T cells induced by peptide-pulsed dendritic cells confer protection against Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(6):3806-13.
2007: Yoshikai Yasunobu
[Roles of natural memory lymphocytes in host defense mechanisms]
Nippon rinsho. Japanese journal of clinical medicine 2007;65 Suppl 2 Pt. 1():109-12.
2007: Eto Masatoshi; Harano Masahiko; Tatsugami Katsunori; Harada Mamoru; Kamiryo Yoriyuki; Kiyoshima Keijiro; Hamaguchi Masumitsu; Tsuneyoshi Masazumi; Yoshikai Yasunobu; Naito Seiji
Cyclophosphamide-using nonmyeloablative allogeneic cell therapy against renal cancer with a reduced risk of graft-versus-host disease.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(3):1029-35.
2007: Kajiwara Takashi; Tomita Yukihiro; Okano Shinji; Iwai Toshiro; Yasunami Youichi; Yoshikai Yasunobu; Nomoto Kikuo; Yasui Hisataka; Tominaga Ryuji
Effects of cyclosporin A on the activation of natural killer T cells induced by alpha-galactosylceramide.
Transplantation 2007;83(2):184-92.
2007: Nakazato Kenji; Yamada Hisakata; Yajima Toshiki; Kagimoto Yoshiko; Kuwano Hiroyuki; Yoshikai Yasunobu
Enforced expression of Bcl-2 partially restores cell numbers but not functions of TCRgammadelta intestinal intraepithelial T lymphocytes in IL-15-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(2):757-64.
2006: Iwai Toshiro; Tomita Yukihiro; Okano Shinji; Shimizu Ichiro; Yasunami Yohichi; Kajiwara Takashi; Yoshikai Yasunobu; Taniguchi Masaru; Nomoto Kikuo; Yasui Hisataka
Regulatory roles of NKT cells in the induction and maintenance of cyclophosphamide-induced tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(12):8400-9.
2006: Hirose Yoshitaka; Murosaki Shinji; Yamamoto Yoshihiro; Yoshikai Yasunobu; Tsuru Tomomi
Daily intake of heat-killed Lactobacillus plantarum L-137 augments acquired immunity in healthy adults.
The Journal of nutrition 2006;136(12):3069-73.
2006: Aizu Keiji; Li Wei; Yajima Toshiki; Arai Toshiyuki; Shimoda Kazuya; Nimura Yuji; Yoshikai Yasunobu
An important role of Tyk2 in APC function of dendritic cells for priming CD8+ T cells producing IFN-gamma.
European journal of immunology 2006;36(11):3060-70.
2006: Nagata Shigeyuki; Okano Shinji; Yonemitsu Yoshikazu; Nakagawa Kazunori; Tomita Yukihiro; Yoshikai Yasunobu; Shimada Mitsuo; Maehara Yoshihiko; Sueishi Katsuo
Critical roles of memory T cells and antidonor immunoglobulin in rejection of allogeneic bone marrow cells in sensitized recipient mice.
Transplantation 2006;82(5):689-98.
2006: Yoshikai Yasunobu
[Crosstalk between innate and adaptive immunity]
Nippon rinsho. Japanese journal of clinical medicine 2006;64(7):1223-8.
2006: Aoi Noriaki; Masuda Tokuko; Murakami Daisuke; Yajima Toshiki; Mizubuchi Hiroyuki; Yamada Hisakata; Kawauchi Hideyuki; Yoshikai Yasunobu
IL-15 prevents allergic rhinitis through reactivation of antigen-specific CD8+ cells.
The Journal of allergy and clinical immunology 2006;117(6):1359-66.
2006: Yu Qingsheng; Tang Ce; Xun Sun; Yajima Toshiki; Takeda Kiyoshi; Yoshikai Yasunobu
MyD88-dependent signaling for IL-15 production plays an important role in maintenance of CD8 alpha alpha TCR alpha beta and TCR gamma delta intestinal intraepithelial lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(10):6180-5.
2006: Kagimoto Yoshiko; Yoshikai Yasunobu
[Immune response against HSV]
Nippon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 3():178-83.
2006: Yoshihara K; Yajima T; Kubo C; Yoshikai Y
Role of interleukin 15 in colitis induced by dextran sulphate sodium in mice.
Gut 2006;55(3):334-41.
2006: Saito Kimika; Yajima Toshiki; Kumabe Shino; Doi Takehiko; Yamada Hisakata; Sad Subash; Shen Hao; Yoshikai Yasunobu
Impaired protection against Mycobacterium bovis bacillus Calmette-Guerin infection in IL-15-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(4):2496-504.
2006: Khajoee V; Saito M; Takada H; Nomura A; Kusuhara K; Yoshida S-I; Yoshikai Y; Hara T
Novel roles of osteopontin and CXC chemokine ligand 7 in the defence against mycobacterial infection.
Clinical and experimental immunology 2006;143(2):260-8.
2006: Yajima Toshiki; Yoshihara Kazufumi; Nakazato Kenji; Kumabe Shino; Koyasu Shigeo; Sad Subash; Shen Hao; Kuwano Hiroyuki; Yoshikai Yasunobu
IL-15 regulates CD8+ T cell contraction during primary infection.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(1):507-15.
2006: Ogawa A; Tagawa T; Nishimura H; Yajima T; Abe T; Arai T; Taniguchi M; Takeda K; Akira S; Nimura Y; Yoshikai Y
Toll-like receptors 2 and 4 are differentially involved in Fas dependent apoptosis in Peyer's patch and the liver at an early stage after bile duct ligation in mice.
Gut 2006;55(1):105-13.
2006: Yoshikai Yasunobu
Immunological protection against mycobacterium tuberculosis infection.
Critical reviews in immunology 2006;26(6):515-26.
2005: Mizubuchi Hiroyuki; Yajima Toshiki; Aoi Noriaki; Tomita Tetsuji; Yoshikai Yasunobu
Isomalto-oligosaccharides polarize Th1-like responses in intestinal and systemic immunity in mice.
The Journal of nutrition 2005;135(12):2857-61.
2005: Harano Masahiko; Eto Masatoshi; Iwai Toshiro; Tatsugami Katsunori; Kiyoshima Keijiro; Kamiryo Yoriyuki; Tsuneyoshi Masazumi; Yoshikai Yasunobu; Naito Seiji
Renal cancer treatment with low levels of mixed chimerism induced by nonmyeloablative regimen using cyclophosphamide in mice.
Cancer research 2005;65(21):10032-40.
2005: Nishimura Hitoshi; Yajima Toshiki; Muta Hiromi; Podack Eckhard R; Tani Kenzaburo; Yoshikai Yasunobu
A novel role of CD30/CD30 ligand signaling in the generation of long-lived memory CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(7):4627-34.
2005: Kamiryo Yoriyuki; Yajima Toshiki; Saito Kimika; Nishimura Hitoshi; Fushimi Takashi; Ohshima Yoshifumi; Tsukamoto Yoshinori; Naito Seiji; Yoshikai Yasunobu
Soluble branched (1,4)-beta-D-glucans from Acetobacter species enhance antitumor activities against MHC class I-negative and -positive malignant melanoma through augmented NK activity and cytotoxic T-cell response.
International journal of cancer. Journal international du cancer 2005;115(5):769-76.
2005: Nishimura Hitoshi; Yoshikai Yasunobu
[Development of vaccine and its immunological mechanism]
Nippon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 5():585-9.
2005: Tagawa Tetsuzo; Yoshikai Yasunobu
[Gamma-delta T cells]
Nippon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 4():149-53.
2005: Yajima Toshiki; Nishimura Hitoshi; Sad Subash; Shen Hao; Kuwano Hiroyuki; Yoshikai Yasunobu
A novel role of IL-15 in early activation of memory CD8+ CTL after reinfection.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(6):3590-7.
2005: Yoshioka Yasuko; Kudo Satsuki; Nishimura Hitoshi; Yajima Toshiki; Kishihara Kenji; Saito Kimika; Suzuki Tatsuo; Suzuki Yumiko; Kuroiwa Shinsuke; Yoshikai Yasunobu
Oral administration of bovine colostrum stimulates intestinal intraepithelial lymphocytes to polarize Th1-type in mice.
International immunopharmacology 2005;5(3):581-90.
2005: Nishimura Hitoshi; Fujimoto Atsushi; Tamura Naoyuki; Yajima Toshiki; Wajjwalku Worawidh; Yoshikai Yasunobu
A novel autoregulatory mechanism for transcriptional activation of the IL-15 gene by a nonsecretable isoform of IL-15 generated by alternative splicing.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(1):19-28.
2005: Musikacharoen Tipayaratn; Oguma Asako; Yoshikai Yasunobu; Chiba Norika; Masuda Akio; Matsuguchi Tetsuya
Interleukin-15 induces IL-12 receptor beta1 gene expression through PU.1 and IRF 3 by targeting chromatin remodeling.
Blood 2005;105(2):711-20.
2005: Eto Masatoshi; Koga Hirofumi; Noma Hideya; Yamaguchi Akito; Yoshikai Yasunobu; Naito Seiji
Importance of urinary interleukin-18 in intravesical immunotherapy with bacillus calmette-guérin for superficial bladder tumors.
Urologia internationalis 2005;75(2):114-8.
2004: Li Wei; Yajima Toshiki; Saito Kimika; Nishimura Hitoshi; Fushimi Takashi; Ohshima Yoshifumi; Tsukamoto Yoshinori; Yoshikai Yasunobu
Immunostimulating properties of intragastrically administered Acetobacter-derived soluble branched (1,4)-beta-D-glucans decrease murine susceptibility to Listeria monocytogenes.
Infection and immunity 2004;72(12):7005-11.
2004: Masuda Akio; Yoshikai Yasunobu; Kume Hiroaki; Matsuguchi Tetsuya
The interaction between GATA proteins and activator protein-1 promotes the transcription of IL-13 in mast cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(9):5564-73.
2004: Tagawa Tetsuzo; Nishimura Hitoshi; Yajima Toshiki; Hara Hiromitsu; Kishihara Kenji; Matsuzaki Goro; Yoshino Ichiro; Maehara Yoshihiko; Yoshikai Yasunobu
Vdelta1+ gammadelta T cells producing CC chemokines may bridge a gap between neutrophils and macrophages in innate immunity during Escherichia coli infection in mice.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(8):5156-64.
2004: Minagawa Ryosuke; Okano Shinji; Tomita Yukihiro; Kishihara Kenji; Yamada Hisakata; Nomoto Kenichi; Shimada Mitsuo; Maehara Yoshihiko; Sugimachi Keizo; Yoshikai Yasunobu; Nomoto Kikuo
The critical role of Fas-Fas ligand interaction in donor-specific transfusion-induced tolerance to H-Y antigen.
Transplantation 2004;78(6):799-806.
2004: Sugimoto Kenji; Ohata Mutsuhiro; Miyoshi Jun; Ishizaki Hiroyoshi; Tsuboi Naotake; Masuda Akio; Yoshikai Yasunobu; Takamoto Masaya; Sugane Kazuo; Matsuo Seiichi; Shimada Yasuhiro; Matsuguchi Tetsuya
A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation.
The Journal of clinical investigation 2004;114(6):857-66.
2004: Abe Tetsuya; Arai Toshiyuki; Ogawa Atsushi; Hiromatsu Takashi; Masuda Akio; Matsuguchi Tetsuya; Nimura Yuji; Yoshikai Yasunobu
Kupffer cell-derived interleukin 10 is responsible for impaired bacterial clearance in bile duct-ligated mice.
Hepatology (Baltimore, Md.) 2004;40(2):414-23.
2004: Yajima Toshiki; Nishimura Hitoshi; Saito Kimika; Kuwano Hiroyuki; Yoshikai Yasunobu
Overexpression of Interleukin-15 increases susceptibility to lipopolysaccharide-induced liver injury in mice primed with Mycobacterium bovis bacillus Calmette-Guerin.
Infection and immunity 2004;72(7):3855-62.
2004: Nishimura Hitoshi; Yajima Toshiki; Kagimoto Yoshiko; Ohata Mutsuhiro; Watase Taketo; Kishihara Kenji; Goshima Fumi; Nishiyama Yukihiro; Yoshikai Yasunobu
Intraepithelial gammadelta T cells may bridge a gap between innate immunity and acquired immunity to herpes simplex virus type 2.
Journal of virology 2004;78(9):4927-30.
2003: Saito Kimika; Yajima Toshiki; Nishimura Hitoshi; Aiba Keiko; Ishimitsu Ryotaro; Matsuguchi Tetsuya; Fushimi Takashi; Ohshima Yoshifumi; Tsukamoto Yoshinori; Yoshikai Yasunobu
Soluble branched beta-(1,4)glucans from Acetobacter species show strong activities to induce interleukin-12 in vitro and inhibit T-helper 2 cellular response with immunoglobulin E production in vivo.
The Journal of biological chemistry 2003;278(40):38571-8.
2003: Matsuguchi Tetsuya; Masuda Akio; Sugimoto Kenji; Nagai Yoshiyuki; Yoshikai Yasunobu
JNK-interacting protein 3 associates with Toll-like receptor 4 and is involved in LPS-mediated JNK activation.
The EMBO journal 2003;22(17):4455-64.
2003: Hiromatsu Takashi; Matsuguchi Tetsuya; Shimizu Hideyuki; Yajima Toshiki; Nishimura Hitoshi; Arai Toshiyuki; Nimura Yuji; Yoshikai Yasunobu
NK T cells stimulated with a ligand for TLR2 at least partly contribute to liver injury caused by Escherichia coli infection in mice.
European journal of immunology 2003;33(9):2511-9.
2003: Kikuchi T; Yoshikai Y; Miyoshi J; Katsuki M; Musikacharoen T; Mitani A; Tanaka S; Noguchi T; Matsuguchi T
Cot/Tpl2 is essential for RANKL induction by lipid A in osteoblasts.
Journal of dental research 2003;82(7):546-50.
2003: Hiromatsu Takashi; Yajima Toshiki; Matsuguchi Tetsuya; Nishimura Hitoshi; Wajjwalku Worawidh; Arai Toshiyuki; Nimura Yuji; Yoshikai Yasunobu
Overexpression of interleukin-15 protects against Escherichia coli-induced shock accompanied by inhibition of tumor necrosis factor-alpha-induced apoptosis.
The Journal of infectious diseases 2003;187(9):1442-51.
2003: Matsuguchi Tetsuya; Takagi Akimitsu; Matsuzaki Takeshi; Nagaoka Masato; Ishikawa Kimika; Yokokura Teruo; Yoshikai Yasunobu
Lipoteichoic acids from Lactobacillus strains elicit strong tumor necrosis factor alpha-inducing activities in macrophages through Toll-like receptor 2.
Clinical and diagnostic laboratory immunology 2003;10(2):259-66.
2003: Musikacharoen Tipayaratn; Yoshikai Yasunobu; Matsuguchi Tetsuya
Histone acetylation and activation of cAMP-response element-binding protein regulate transcriptional activation of MKP-M in lipopolysaccharide-stimulated macrophages.
The Journal of biological chemistry 2003;278(11):9167-75.
2003: Ishimitsu Ryotaro; Yajima Toshiki; Nishimura Hitoshi; Kawauchi Hideyuki; Yoshikai Yasunobu
NKT cells are dispensable in the induction of oral tolerance but are indispensable in the abrogation of oral tolerance by prostaglandin E.
European journal of immunology 2003;33(1):183-93.
2002: Liu Tie; Matsuguchi Tetsuya; Tsuboi Naotake; Yajima Toshiki; Yoshikai Yasunobu
Differences in expression of toll-like receptors and their reactivities in dendritic cells in BALB/c and C57BL/6 mice.
Infection and immunity 2002;70(12):6638-45.
2002: Umemura Masayuki; Nishimura Hitoshi; Yajima Toshiki; Wajjwalk Worawid; Matsuguchi Testuya; Takahashi Masahide; Nishiyama Yukihiro; Makino Masahiko; Nagai Yoshiyuki; Yoshikai Yasunobu
Overexpression of interleukin-15 prevents the development of murine retrovirus-induced acquired immunodeficiency syndrome.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(13):1755-63.
2002: Shimizu Hideyuki; Matsuguchi Tetsuya; Fukuda Yoshihide; Nakano Isao; Hayakawa Tetsuo; Takeuchi Osamu; Akira Shizuo; Umemura Masayuki; Suda Takashi; Yoshikai Yasunobu
Toll-like receptor 2 contributes to liver injury by Salmonella infection through Fas ligand expression on NKT cells in mice.
Gastroenterology 2002;123(4):1265-77.
2002: Masuda Akio; Yoshikai Yasunobu; Aiba Keiko; Matsuguchi Tetsuya
Th2 cytokine production from mast cells is directly induced by lipopolysaccharide and distinctly regulated by c-Jun N-terminal kinase and p38 pathways.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(7):3801-10.
2002: Tsuboi Naotake; Yoshikai Yasunobu; Matsuo Seiichi; Kikuchi Takeshi; Iwami Ken-Ichiro; Nagai Yoshiyuki; Takeuchi Osamu; Akira Shizuo; Matsuguchi Tetsuya
Roles of toll-like receptors in C-C chemokine production by renal tubular epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(4):2026-33.
2002: Yajima Toshiki; Nishimura Hitoshi; Wajjwalku Worawidh; Harada Mamoru; Kuwano Hiroyuki; Yoshikai Yasunobu
Overexpression of interleukin-15 in vivo enhances antitumor activity against MHC class I-negative and -positive malignant melanoma through augmented NK activity and cytotoxic T-cell response.
International journal of cancer. Journal international du cancer 2002;99(4):573-8.
2002: Itoh Naoto; Nishimura Hitoshi; Matsuguchi Tetsuya; Yajima Toshiki; Mokuno Yasuji; Hiromatsu Takashi; Nimura Yuji; Yoshikai Yasunobu
CD8 alpha-deficient mice are highly susceptible to 5-fluorouracil-induced lethality.
Clinical and diagnostic laboratory immunology 2002;9(3):550-7.
2002: Matsuzaki Goro; Yamada Hisakata; Kishihara Kenji; Yoshikai Yasunobu; Nomoto Kikuo
Mechanism of murine Vgamma1+ gamma delta T cell-mediated innate immune response against Listeria monocytogenes infection.
European journal of immunology 2002;32(4):928-35.
2002: Yajima Toshiki; Nishimura Hitoshi; Ishimitsu Ryotaro; Watase Taketo; Busch Dirk H; Pamer Eric G; Kuwano Hiroyuki; Yoshikai Yasunobu
Overexpression of IL-15 in vivo increases antigen-driven memory CD8+ T cells following a microbe exposure.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(3):1198-203.
2002: Murosak Shinji; Muroyama Koutarou; Yamamoto Yoshihiro; Liu Tiei; Yoshikai Yasunobu
Nigerooligosaccharides augments natural killer activity of hepatic mononuclear cells in mice.
International immunopharmacology 2002;2(1):151-9.
2001: Kato M; Matsuguchi T; Ono Y; Hattori R; Ohshima S; Yoshikai Y
Characterization of CD28(-)CD4(+) T cells in living kidney transplant patients with long-term allograft acceptance.
Human immunology 2001;62(12):1335-45.
2001: Ishiguro K; Kadomatsu K; Kojima T; Muramatsu H; Iwase M; Yoshikai Y; Yanada M; Yamamoto K; Matsushita T; Nishimura M; Kusugami K; Saito H; Muramatsu T
Syndecan-4 deficiency leads to high mortality of lipopolysaccharide-injected mice.
The Journal of biological chemistry 2001;276(50):47483-8.
2001: Matsuguchi T; Musikacharoen T; Johnson T R; Kraft A S; Yoshikai Y
A novel mitogen-activated protein kinase phosphatase is an important negative regulator of lipopolysaccharide-mediated c-Jun N-terminal kinase activation in mouse macrophage cell lines.
Molecular and cellular biology 2001;21(20):6999-7009.
2001: Umemura M; Nishimura H; Hirose K; Matsuguchi T; Yoshikai Y
Overexpression of IL-15 in vivo enhances protection against Mycobacterium bovis bacillus Calmette-Guérin infection via augmentation of NK and T cytotoxic 1 responses.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(2):946-56.
2001: Masuda A; Matsuguchi T; Yamaki K; Hayakawa T; Yoshikai Y
Interleukin-15 prevents mouse mast cell apoptosis through STAT6-mediated Bcl-xL expression.
The Journal of biological chemistry 2001;276(28):26107-13.
2001: Ishimitsu R; Nishimura H; Kawauchi H; Kawakita T; Yoshikai Y
Dichotomous effect of a traditional Japanese medicine, bu-zhong-yi-qi-tang on allergic asthma in mice.
International immunopharmacology 2001;1(5):857-65.
2001: Musikacharoen T; Matsuguchi T; Kikuchi T; Yoshikai Y
NF-kappa B and STAT5 play important roles in the regulation of mouse Toll-like receptor 2 gene expression.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(7):4516-24.
2001: Yajima T; Nishimura H; Ishimitsu R; Yamamura K; Watase T; Busch D H; Pamer E G; Kuwano H; Yoshikai Y
Memory phenotype CD8(+) T cells in IL-15 transgenic mice are involved in early protection against a primary infection with Listeria monocytogenes.
European journal of immunology 2001;31(3):757-66.
2001: Kikuchi T; Matsuguchi T; Tsuboi N; Mitani A; Tanaka S; Matsuoka M; Yamamoto G; Hishikawa T; Noguchi T; Yoshikai Y
Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via Toll-like receptors.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(5):3574-9.
2001: Ishimitsu R; Nishimura H; Yajima T; Watase T; Kawauchi H; Yoshikai Y
Overexpression of IL-15 in vivo enhances Tc1 response, which inhibits allergic inflammation in a murine model of asthma.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(3):1991-2001.
2001: Nishimura H; Tagaya M; Tsunobuchi H; Suzuki H; Nakashima I; Yoshikai Y
Mice lacking interleukin-2 (IL-2)/IL-15 receptor beta chain are susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar choleraesuis but mice lacking IL-2 are resistant.
Infection and immunity 2001;69(2):1226-9.
2001: Umemura M; Hirose K; Wajjwaiku W; Nishimura H; Matsuguchi T; Gotoh Y; Takahashi M; Makino M; Yoshikai Y
Impaired IL-15 production associated with susceptibility of murine AIDS to mycobacterial infection.
Journal of leukocyte biology 2001;69(1):138-48.
2001: Hara T; Nishimura H; Hasegawa Y; Yoshikai Y
Thymus-dependent modulation of Ly49 inhibitory receptor expression on NK1.1+gamma/delta T cells.
Immunology 2001;102(1):24-30.
2000: Iwami K I; Matsuguchi T; Masuda A; Kikuchi T; Musikacharoen T; Yoshikai Y
Cutting edge: naturally occurring soluble form of mouse Toll-like receptor 4 inhibits lipopolysaccharide signaling.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):6682-6.
2000: Matsuguchi T; Musikacharoen T; Ogawa T; Yoshikai Y
Gene expressions of Toll-like receptor 2, but not Toll-like receptor 4, is induced by LPS and inflammatory cytokines in mouse macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(10):5767-72.
2000: Tsunobuchi H; Nishimura H; Goshima F; Daikoku T; Nishiyama Y; Yoshikai Y
Memory-type CD8+ T cells protect IL-2 receptor alpha-deficient mice from systemic infection with herpes simplex virus type 2.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(8):4552-60.
2000: Tsunobuchi H; Nishimura H; Goshima F; Daikoku T; Suzuki H; Nakashima I; Nishiyama Y; Yoshikai Y
A protective role of interleukin-15 in a mouse model for systemic infection with herpes simplex virus.
Virology 2000;275(1):57-66.
2000: Umemura M; Wajjwalku W; Upragarin N; Liu T; Nishimura H; Matsuguchi T; Nishiyama Y; Wilson G M; Yoshikai Y
Expression of mouse mammary tumor virus superantigen accelerates tumorigenicity of myeloma cells.
Journal of virology 2000;74(18):8226-33.
2000: Masuda A; Matsuguchi T; Yamaki K; Hayakawa T; Kubo M; LaRochelle W J; Yoshikai Y
Interleukin-15 induces rapid tyrosine phosphorylation of STAT6 and the expression of interleukin-4 in mouse mast cells.
The Journal of biological chemistry 2000;275(38):29331-7.
2000: Mokuno Y; Matsuguchi T; Takano M; Nishimura H; Washizu J; Ogawa T; Takeuchi O; Akira S; Nimura Y; Yoshikai Y
Expression of toll-like receptor 2 on gamma delta T cells bearing invariant V gamma 6/V delta 1 induced by Escherichia coli infection in mice.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(2):931-40.
2000: Murosaki S; Muroyama K; Yamamoto Y; Yoshikai Y
Antitumor effect of heat-killed Lactobacillus plantarum L-137 through restoration of impaired interleukin-12 production in tumor-bearing mice.
Cancer immunology, immunotherapy : CII 2000;49(3):157-64.
2000: Naiki Y; Nishimura H; Itohara S; Yoshikai Y
gammadelta T cells may dichotomously modulate infection with avirulent Salmonella choleraesuis via IFN-gamma and IL-13 in mice.
Cellular immunology 2000;202(1):61-9.
2000: Liu T; Nishimura H; Matsuguchi T; Yoshikai Y
Differences in interleukin-12 and -15 production by dendritic cells at the early stage of Listeria monocytogenes infection between BALB/c and C57 BL/6 mice.
Cellular immunology 2000;202(1):31-40.
2000: Kimura K; Nishimura H; Matsuzaki T; Yokokura T; Nimura Y; Yoshikai Y
Synergistic effect of interleukin-15 and interleukin-12 on antitumor activity in a murine malignant pleurisy model.
Cancer immunology, immunotherapy : CII 2000;49(2):71-7.
2000: Yoshikai Y; Nishimura H
The role of interleukin 15 in mounting an immune response against microbial infections.
Microbes and infection / Institut Pasteur 2000;2(4):381-9.
2000: Ninomiya T; Takimoto H; Matsuzaki G; Hamano S; Yoshida H; Yoshikai Y; Kimura G; Nomoto K
Vgamma1+ gammadelta T cells play protective roles at an early phase of murine cytomegalovirus infection through production of interferon-gamma.
Immunology 2000;99(2):187-94.
2000: Matsuguchi T; Takagi K; Musikacharoen T; Yoshikai Y
Gene expressions of lipopolysaccharide receptors, toll-like receptors 2 and 4, are differently regulated in mouse T lymphocytes.
Blood 2000;95(4):1378-85.
2000: Nishimura H; Yajima T; Naiki Y; Tsunobuchi H; Umemura M; Itano K; Matsuguchi T; Suzuki M; Ohashi P S; Yoshikai Y
Differential roles of interleukin 15 mRNA isoforms generated by alternative splicing in immune responses in vivo.
The Journal of experimental medicine 2000;191(1):157-70.
1999: Mokuno Y; Takano M; Matsuguchi T; Nishimura H; Washizu J; Naiki Y; Nimura Y; Yoshikai Y
Prostaglandin E(1) protects against liver injury induced by Escherichia coli infection via a dominant Th2-like response of liver T cells in mice.
Hepatology (Baltimore, Md.) 1999;30(6):1464-72.
1999: Tanaka S; Kimura Y; Mitani A; Yamamoto G; Nishimura H; Spallek R; Singh M; Noguchi T; Yoshikai Y
Activation of T cells recognizing an epitope of heat-shock protein 70 can protect against rat adjuvant arthritis.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(10):5560-5.
1999: Mayumi T; Takezawa J; Takahashi H; Yamaguchi H; Nishimura H; Enomoto A; Ichiyama S; Yoshikai Y
IL-15 is elevated in the patients of postoperative enterocolitis.
Cytokine 1999;11(11):888-93.
1999: Hirose K; Nishimura H; Matsuguchi T; Yoshikai Y
Endogenous IL-15 might be responsible for early protection by natural killer cells against infection with an avirulent strain of Salmonella choleraesuis in mice.
Journal of leukocyte biology 1999;66(3):382-90.
1999: Naiki Y; Nishimura H; Kawano T; Tanaka Y; Itohara S; Taniguchi M; Yoshikai Y
Regulatory role of peritoneal NK1.1+ alpha beta T cells in IL-12 production during Salmonella infection.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(4):2057-63.
1999: Ishigami M; Nishimura H; Naiki Y; Yoshioka K; Kawano T; Tanaka Y; Taniguchi M; Kakumu S; Yoshikai Y
The roles of intrahepatic Valpha14(+) NK1.1(+) T cells for liver injury induced by Salmonella infection in mice.
Hepatology (Baltimore, Md.) 1999;29(6):1799-808.
1999: Mitani A; Nishimura H; Hirose K; Washizu J; Kimura Y; Tanaka S; Yamamoto G; Noguchi T; Yoshikai Y
Interleukin-15 production at the early stage after oral infection with Listeria monocytogenes in mice.
Immunology 1999;97(1):92-9.
1999: Kimura K; Nishimura H; Hirose K; Matsuguchi T; Nimura Y; Yoshikai Y
Immunogene therapy of murine fibrosarcoma using IL-15 gene with high translation efficiency.
European journal of immunology 1999;29(5):1532-42.
1999: Murosaki S; Muroyama K; Yamamoto Y; Kusaka H; Liu T; Yoshikai Y
Immunopotentiating activity of nigerooligosaccharides for the T helper 1-like immune response in mice.
Bioscience, biotechnology, and biochemistry 1999;63(2):373-8.
1999: Nishimura H; Washizu J; Naiki Y; Hara T; Fukui Y; Sasazuki T; Yoshikai Y
MHC class II-dependent NK1.1+ gammadelta T cells are induced in mice by Salmonella infection.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(3):1573-81.
1999: Yamada K; Kimura Y; Nishimura H; Namii Y; Murase M; Yoshikai Y
Characterization of CD4+ CD8alphaalpha+ and CD4-CD8alphaalpha+ intestinal intraepithelial lymphocytes in rats.
International immunology 1999;11(1):21-8.
1999: Yoshikai Y
The interaction of intestinal epithelial cells and intraepithelial lymphocytes in host defense.
Immunologic research 1999;20(3):219-35.
1999: Ishigami M; Nishimura H; Yoshioka K; Kakumu S; Yoshikai Y
The role of intrahepatic gammadelta-T cells for liver injury induced by Salmonella infection in mouse.
Microbiology and immunology 1999;43(5):461-9.
1998: Hirose K; Suzuki H; Nishimura H; Mitani A; Washizu J; Matsuguchi T; Yoshikai Y
Interleukin-15 may be responsible for early activation of intestinal intraepithelial lymphocytes after oral infection with Listeria monocytogenes in rats.
Infection and immunity 1998;66(12):5677-83.
1998: Takano M; Nishimura H; Kimura Y; Washizu J; Mokuno Y; Nimura Y; Yoshikai Y
Prostaglandin E2 protects against liver injury after Escherichia coli infection but hampers the resolution of the infection in mice.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(6):3019-25.
1998: Murosaki S; Yamamoto Y; Ito K; Inokuchi T; Kusaka H; Ikeda H; Yoshikai Y
Heat-killed Lactobacillus plantarum L-137 suppresses naturally fed antigen-specific IgE production by stimulation of IL-12 production in mice.
The Journal of allergy and clinical immunology 1998;102(1):57-64.
1998: Takano M; Nishimura H; Kimura Y; Mokuno Y; Washizu J; Itohara S; Nimura Y; Yoshikai Y
Protective roles of gamma delta T cells and interleukin-15 in Escherichia coli infection in mice.
Infection and immunity 1998;66(7):3270-8.
1998: Yoshikai Y
[The roles of heat shock proteins in host defense against bacterial infection]
Rinsho byori. The Japanese journal of clinical pathology 1998;46(6):564-73.
1998: Takano M; Arai T; Mokuno Y; Nishimura H; Nimura Y; Yoshikai Y
Dibutyryl cyclic adenosine monophosphate protects mice against tumor necrosis factor-alpha-induced hepatocyte apoptosis accompanied by increased heat shock protein 70 expression.
Cell stress & chaperones 1998;3(2):109-17.
1998: Sakai T; Kusugami K; Nishimura H; Ando T; Yamaguchi T; Ohsuga M; Ina K; Enomoto A; Kimura Y; Yoshikai Y
Interleukin 15 activity in the rectal mucosa of inflammatory bowel disease.
Gastroenterology 1998;114(6):1237-43.
1998: Washizu J; Nishimura H; Nakamura N; Nimura Y; Yoshikai Y
The NF-kappaB binding site is essential for transcriptional activation of the IL-15 gene.
Immunogenetics 1998;48(1):1-7.
1998: Kimura Y; Yamada K; Sakai T; Mishima K; Nishimura H; Matsumoto Y; Singh M; Yoshikai Y
The regulatory role of heat shock protein 70-reactive CD4+ T cells during rat listeriosis.
International immunology 1998;10(2):117-30.
1998: Nishimura H; Washizu J; Nakamura N; Enomoto A; Yoshikai Y
Translational efficiency is up-regulated by alternative exon in murine IL-15 mRNA.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(2):936-42.
1997: Kobayashi N; Hiromatsu K; Matsuzaki G; Harada M; Matsumoto Y; Nomoto K; Yoshikai Y
A sustained increase of cytosolic Ca2+ in gammadelta T cells triggered by co-stimulation via TCR/CD3 and LFA-1.
Cell calcium 1997;22(6):421-30.
1997: Ito K; Inagaki-Ohara K; Murosaki S; Nishimura H; Shimokata T; Torii S; Matsuda T; Yoshikai Y
Murine model of IgE production with a predominant Th2-response by feeding protein antigen without adjuvants.
European journal of immunology 1997;27(12):3427-37.
1997: Inagaki-Ohara K; Nishimura H; Mitani A; Yoshikai Y
Interleukin-15 preferentially promotes the growth of intestinal intraepithelial lymphocytes bearing gamma delta T cell receptor in mice.
European journal of immunology 1997;27(11):2885-91.
1997: Inagaki-Ohara K; Nishimura H; Sakai T; Lynch D H; Yoshikai Y
Potential for involvement of Fas antigen/Fas ligand interaction in apoptosis of epithelial cells by intraepithelial lymphocytes in murine small intestine.
Laboratory investigation; a journal of technical methods and pathology 1997;77(5):421-9.
1997: Toki S; Hiromatsu K; Aoki Y; Makino M; Yoshikai Y
Protective effects of granulocyte colony-stimulating factor on endotoxin shock in mice with retrovirus-induced immunodeficiency syndrome.
Cytokine 1997;9(10):781-6.
1997: Upragarin N; Nishimura H; Wajjwalku W; Ando Y; Nagafuchi S; Watanabe T; Yoshikai Y
T cells bearing Vbeta8 are preferentially infected with exogenous mouse mammary tumor virus.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(5):2189-95.
1997: Sakai T; Kimura Y; Inagaki-Ohara K; Kusugami K; Lynch D H; Yoshikai Y
Fas-mediated cytotoxicity by intestinal intraepithelial lymphocytes during acute graft-versus-host disease in mice.
Gastroenterology 1997;113(1):168-74.
1997: Fuse Y; Nishimura H; Maeda K; Yoshikai Y
CD95 (Fas) may control the expansion of activated T cells after elimination of bacteria in murine listeriosis.
Infection and immunity 1997;65(5):1883-91.
1997: Nishimura H; Emoto M; Kimura K; Yoshikai Y
Hsp70 protects macrophages infected with Salmonella choleraesuis against TNF-alpha-induced cell death.
Cell stress & chaperones 1997;2(1):50-9.
1997: Kobayashi Y; Kawai K; Ito K; Honda H; Sobue G; Yoshikai Y
Aggravation of murine experimental allergic encephalomyelitis by administration of T-cell receptor gammadelta-specific antibody.
Journal of neuroimmunology 1997;73(1-2):169-74.
1997: Enomoto A; Nishimura H; Yoshikai Y
Predominant appearance of NK1.1+ T cells producing IL-4 may be involved in the increased susceptibility of mice with the beige mutation during Salmonella infection.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(5):2268-77.
1997: Yoshikai Y; Kidokoro H; Kimura K; Aoki Y; Makino M; Hiromatsu K
Clonal expansion of superantigen-reactive T cells is resistant to FK506 in mice with AIDS.
Journal of virology 1997;71(1):746-9.
1997: Inagaki-Ohara K; Sakai T; Koya G; Awaya A; Yoshikai Y
A thymic hormone protects mice from enteropathy during acute graft-versus-host disease.
Microbiology and immunology 1997;41(11):883-9.
1997: Aoki Y; Yoshikai Y
Further clonal expansion of T cells upon rechallenge of superantigen staphylococcal enterotoxin A.
Microbiology and immunology 1997;41(4):337-43.
1997: Hiromatsu K; Usami J; Aoki Y; Makino M; Yoshikai Y
Accelerated progression of a murine retrovirus-induced immunodeficiency syndrome in Fas mutant C57BL/6 lpr/lpr mice.
Microbiology and immunology 1997;41(3):221-7.
1997: Murosaki S; Inagaki-Ohara K; Kusaka H; Ikeda H; Yoshikai Y
Apoptosis of intestinal intraepithelial lymphocytes induced by exogenous and endogenous glucocorticoids.
Microbiology and immunology 1997;41(2):139-48.
1996: Hiromatsu K; Nishimura H; Kimura K; Aoki Y; Usami J; Kobayashi N; Makino M; Yoshikai Y
Th0-like CD4+ T cells protect mice with murine retrovirus-induced immunodeficiency syndrome (MAIDS) against co-infection with Listeria monocytogenes.
Immunology 1996;89(4):532-8.
1996: Usami J; Hiromatsu K; Aoki Y; Kobayashi N; Makino M; Yagita H; Matsumoto Y; Maeda K; Yoshikai Y
Apoptosis by CD95 (Fas)-dependent and -independent mechanisms in Peyer's patch lymphocytes in murine retrovirus-induced immunodeficiency syndrome.
Journal of virology 1996;70(12):8917-25.
1996: Ando Y; Wajjwalku W; Kishihara K; Arai T; Niimi N; Hiromatsu K; Morishima T; Yoshikai Y
CD4 expression is important but not essential for infection with exogenous mouse mammary tumor virus.
Immunobiology 1996;195(3):376-84.
1996: Kawai K; Kobayashi Y; Shiratori M; Sobue G; Tamatani T; Miyasaka M; Yoshikai Y
Intrathecal administration of antibodies against LFA-1 and against ICAM-1 suppresses experimental allergic encephalomyelitis in rats.
Cellular immunology 1996;171(2):262-8.
1996: Inagaki H; Suzuki T; Nomoto K; Yoshikai Y
Increased susceptibility to primary infection with Listeria monocytogenes in germfree mice may be due to lack of accumulation of L-selectin+ CD44+ T cells in sites of inflammation.
Infection and immunity 1996;64(8):3280-7.
1996: Iwata T; Kamei Y; Esaki S; Takada T; Torii S; Yamashita A; Tomida S; Tamatani T; Miyasaka M; Yoshikai Y
Immunosuppression by anti-ICAM-1 and anti-LFA-1 monoclonal antibodies of free and vascularized skin allograft rejection.
Immunobiology 1996;195(2):160-71.
1996: Inagaki-Ohara K; Kobayashi N; Nishimura H; Sakai T; Matsumoto Y; Hiromatsu K; Awaya A; Yoshikai Y
Effects of a nonapeptide thymic hormone on intestinal intraepithelial lymphocytes in mice following administration of 5-fluorouracil.
Cellular immunology 1996;171(1):30-40.
1996: Kimura Y; Tomida S; Matsumoto Y; Hiromatsu K; Yoshikai Y
Evidence for the early recruitment of T-cell receptor gamma delta+ T cells during rat listeriosis.
Immunology 1996;87(1):21-8.
1996: Nishimura H; Hiromatsu K; Kobayashi N; Grabstein K H; Paxton R; Sugamura K; Bluestone J A; Yoshikai Y
IL-15 is a novel growth factor for murine gamma delta T cells induced by Salmonella infection.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(2):663-9.
1996: Kimura Y; Sakai T; Takeuchi M; Matsumoto Y; Watanabe K; Yuuki M; Takada T; Yoshikai Y
An unique CD4+CD8+ intestinal intraepithelial lymphocyte specific for DnaK (Escherichia coli HSP70) may be selected by intestinal microflora of rats.
Immunobiology 1996;196(5):550-66.
1996: Morita H; Isobe K; Cai Z; Miyazaki T; Matsumoto Y; Shinzato T; Yoshikai Y; Kimata K; Maeda K
Thy-1 antigen mediates apoptosis of rat glomerular cells in vitro and in vivo.
Nephron 1996;73(2):293-8.
1996: Nakamura N; Wajjwalku W; Nishimura H; Okubo H; Niimi N; Ando Y; Yoshikai Y
Nucleotide sequences of env and 3'LTROrf genes of endogenous mouse mammary tumor viruses encoding superantigen specific for TcrVbeta2.
Immunogenetics 1996;44(4):319-20.
1995: Arai T; Hiromatsu K; Kobayashi N; Takano M; Ishida H; Nimura Y; Yoshikai Y
IL-10 is involved in the protective effect of dibutyryl cyclic adenosine monophosphate on endotoxin-induced inflammatory liver injury.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(12):5743-9.
1995: Niimi N; Wajjwalku W; Ando Y; Nakamura N; Ueda M; Yoshikai Y
A novel V beta 2-specific endogenous mouse mammary tumor virus which is capable of producing a milk-borne exogenous virus.
Journal of virology 1995;69(11):7269-73.
1995: Matsumoto Y; Shinzato T; Amano I; Takai I; Kimura Y; Morita H; Miwa M; Nakane K; Yoshikai Y; Maeda K
Relationship between susceptibility to apoptosis and Fas expression in peripheral blood T cells from uremic patients: a possible mechanism for lymphopenia in chronic renal failure.
Biochemical and biophysical research communications 1995;215(1):98-105.
1995: Aoki Y; Hiromatsu K; Arai T; Usami J; Makino M; Ishida H; Yoshikai Y
Lethal shock is inducible by lipopolysaccharide but not by superantigen in mice with retrovirus-induced immunodeficiency syndrome.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(7):3494-500.
1995: Usami J; Hiromatsu K; Matsumoto Y; Maeda K; Inagaki H; Suzuki T; Yoshikai Y
A protective role of gamma delta T cells in primary infection with Listeria monocytogenes in autoimmune non-obese diabetic mice.
Immunology 1995;86(2):199-205.
1995: Emoto M; Nishimura H; Sakai T; Hiromatsu K; Gomi H; Itohara S; Yoshikai Y
Mice deficient in gamma delta T cells are resistant to lethal infection with Salmonella choleraesuis.
Infection and immunity 1995;63(9):3736-8.
1995: Kobayashi Y; Kawai K; Honda H; Tomida S; Niimi N; Tamatani T; Miyasaka M; Yoshikai Y
Antibodies against leukocyte function-associated antigen-1 and against intercellular adhesion molecule-1 together suppress the progression of experimental allergic encephalomyelitis.
Cellular immunology 1995;164(2):295-305.
1995: Arai T; Hiromatsu K; Nishimura H; Kimura Y; Kobayashi N; Ishida H; Nimura Y; Yoshikai Y
Endogenous interleukin 10 prevents apoptosis in macrophages during Salmonella infection.
Biochemical and biophysical research communications 1995;213(2):600-7.
1995: Aoki Y; Hiromatsu K; Kobayashi N; Hotta T; Saito H; Igarashi H; Niho Y; Yoshikai Y
Protective effect of granulocyte colony-stimulating factor against T-cell-meditated lethal shock triggered by superantigens.
Blood 1995;86(4):1420-7.
1995: Arai T; Hiromatsu K; Nishimura H; Kimura Y; Kobayashi N; Ishida H; Nimura Y; Yoshikai Y
Effects of in vivo administration of anti-IL-10 monoclonal antibody on the host defence mechanism against murine Salmonella infection.
Immunology 1995;85(3):381-8.
1995: Ando Y; Wajjwalku W; Niimi N; Hiromatsu K; Morishima T; Yoshikai Y
Concomitant infection with exogenous mouse mammary tumor virus encoding I-E-dependent superantigen in I-E-negative mouse strain.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(12):6219-26.
1995: Hasegawa T; Okuda M; Makino M; Hiromatsu K; Nomoto K; Yoshikai Y
Hot water extracts of Chlorella vulgaris reduce opportunistic infection with Listeria monocytogenes in C57BL/6 mice infected with LP-BM5 murine leukemia viruses.
International journal of immunopharmacology 1995;17(6):505-12.
1995: Suzuki T; Hiromatsu K; Ando Y; Okamoto T; Tomoda Y; Yoshikai Y
Regulatory role of gamma delta T cells in uterine intraepithelial lymphocytes in maternal antifetal immune response.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(9):4476-84.
1995: Nishimura H; Emoto M; Hiromatsu K; Yamamoto S; Matsuura K; Gomi H; Ikeda T; Itohara S; Yoshikai Y
The role of gamma delta T cells in priming macrophages to produce tumor necrosis factor-alpha.
European journal of immunology 1995;25(5):1465-8.
1995: Sakai T; Ohara-Inagaki K; Tsuzuki T; Yoshikai Y
Host intestinal intraepithelial gamma delta T lymphocytes present during acute graft-versus-host disease in mice may contribute to the development of enteropathy.
European journal of immunology 1995;25(1):87-91.
1995: Atsuta N; Nishimura H; Nakamura N; Emoto M; Iwatsuki T; Yoshikai Y
Diversity of V gamma gene segments rearranged to the J gamma 4 gene in mice.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(2):676-84.
1995: Wajjwalku W; Ando Y; Niimi N; Yoshikai Y
A novel exogenous mammary tumor virus encoding MHC class II H2E-independent superantigen specific for Tcr-V beta 14.
Immunogenetics 1995;41(2-3):156-8.
1994: Hiromatsu K; Kobayashi Y; Yoshikai Y
[The involvement of gamma delta T cells in neurological disorders]
Nippon rinsho. Japanese journal of clinical medicine 1994;52(11):2824-9.
1994: Matsumoto Y; Hiromatsu K; Sakai T; Kobayashi Y; Kimura Y; Usami J; Shinzato T; Maeda K; Yoshikai Y
Co-stimulation with LFA-1 triggers apoptosis in gamma delta T cells on T cell receptor engagement.
European journal of immunology 1994;24(10):2441-5.
1994: Aoki Y; Hiromatsu K; Usami J; Makino M; Igarashi H; Ogasawara J; Nagata S; Yoshikai Y
Clonal expansion but lack of subsequent clonal deletion of bacterial superantigen-reactive T cells in murine retroviral infection.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(8):3611-21.
1994: Hiromatsu K; Aoki Y; Makino M; Matsumoto Y; Mizuochi T; Gotoh Y; Nomoto K; Ogasawara J; Nagata S; Yoshikai Y
Increased Fas antigen expression in murine retrovirus-induced immunodeficiency syndrome, MAIDS.
European journal of immunology 1994;24(10):2446-51.
1994: Tomida S; Hasegawa T; Takeuchi M; Niimi N; Ueda M; Kaneda T; Tanaka T; Tamatani T; Miyasaka M; Yoshikai Y
Intercellular adhesion molecule-1 and leukocyte function-associated antigen-1 are involved in protection mediated by CD3+TCR alpha beta- T cells at the early stage after infection with Listeria monocytogenes in rats.
International immunology 1994;6(7):955-61.
1994: Ogasawara T; Emoto M; Kiyotani K; Shimokata K; Yoshida T; Nagai Y; Yoshikai Y
Sendai virus pneumonia: evidence for the early recruitment of gamma delta T cells during the disease course.
Journal of virology 1994;68(6):4022-7.
1994: Matsuura A; Katsuno M; Suzuki Y; Ito T; Yasuura K; Abe T; Yoshikai Y
Cyclophosphamide-induced tolerance in fully allogeneic heart transplantation in mice.
Cellular immunology 1994;155(2):501-7.
1994: Hasegawa T; Okuda M; Nomoto K; Yoshikai Y
Augmentation of the resistance against Listeria monocytogenes by oral administration of a hot water extract of Chlorella vulgaris in mice.
Immunopharmacology and immunotoxicology 1994;16(2):191-202.
1994: Tsuzuki T; Yoshikai Y; Ito M; Mori N; Ohbayashi M; Asai J
Kinetics of intestinal intraepithelial lymphocytes during acute graft-versus-host disease in mice.
European journal of immunology 1994;24(3):709-15.
1994: Niimi N; Wajjwalku W; Ando Y; Tomida S; Takeuchi M; Ueda M; Kaneda T; Yoshikai Y
Delay in expression of a mammary tumor provirus is responsible for defective clonal deletion during postnatal period.
European journal of immunology 1994;24(2):488-91.
1994: Miyazaki H; Tanaka M; Takeda Y; Takeo S; Nomoto K; Yoshikai Y
Effect of antitumor polysaccharide SPR-901 on antitumor activity in combination with 5-FU.
International journal of immunopharmacology 1994;16(2):163-70.
1994: Matsumoto Y; Emoto M; Usami J; Maeda K; Yoshikai Y
A protective role of extrathymic alpha beta TcR cells in the liver in primary murine salmonellosis.
Immunology 1994;81(1):8-14.
1994: Niimi N; Wajjwalku W; Ando Y; Tomida S; Ueda M; Yoshikai Y
A new gene encoding the ligand for deletion of T cells bearing Tcrb-V6 and V8.1 (Mtv-50).
Immunogenetics 1994;40(4):312.
1993: Yoshikai Y
[Viral superantigens]
Uirusu. Journal of virology 1993;43(1):119-27.
1993: Takeuchi M; Miyazaki H; Mirokawa K; Yokokura T; Yoshikai Y
Age-related changes of T cell subsets in intestinal intraepithelial lymphocytes of mice.
European journal of immunology 1993;23(6):1409-11.
1993: Emoto M; Naito T; Nakamura R; Yoshikai Y
Different appearance of gamma delta T cells during salmonellosis between Ityr and Itys mice.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(8 Pt 1):3411-20.
1993: Wajjwalku W; Tomida S; Takahashi M; Matsuyama M; Yoshikai Y
A gene encoding the ligand for deletion of T cells bearing TcrV beta 6 and V beta 8.1 cosegregates with a new endogenous mouse mammary tumor virus.
Immunogenetics 1993;37(5):397-400.
1992: Takeuchi M; Iwasaki A; Nomoto K; Yoshikai Y
Rat thymic epithelium positively selects mouse T cells with specificity for rat MHC class II antigens but fails to induce detectable tolerance in the mouse T cells to the rat MHC antigens.
Immunobiology 1992;186(5):421-34.
1992: Hasegawa T; Tanaka T; Yoshikai Y
The appearance and role of gamma delta T cells in the peritoneal cavity and liver during primary infection with Listeria monocytogenes in rats.
International immunology 1992;4(10):1129-36.
1992: Emoto M; Danbara H; Yoshikai Y
Induction of gamma/delta T cells in murine salmonellosis by an avirulent but not by a virulent strain of Salmonella choleraesuis.
The Journal of experimental medicine 1992;176(2):363-72.
1992: Yoshikai Y
Regulatory role of heat shock protein-specific T cells in host defense.
Nagoya journal of medical science 1992;54(1-4):11-26.
1992: Takimoto H; Nakamura T; Takeuchi M; Sumi Y; Tanaka T; Nomoto K; Yoshikai Y
Age-associated increase in number of CD4+CD8+ intestinal intraepithelial lymphocytes in rats.
European journal of immunology 1992;22(1):159-64.
1991: Yoshikai Y; Ishida A; Murosaki S; Ando T; Nomoto K
Sequential appearance of T-cell receptor gamma delta- and alpha beta-bearing intestinal intra-epithelial lymphocytes in mice after irradiation.
Immunology 1991;74(4):583-8.
1991: Yoshikai Y
[Participation of gamma/delta-T cells in the protection against mycobacterial infection]
Kekkaku : [Tuberculosis] 1991;66(9):621-7.
1991: Yoshikai Y
Gamma/delta T cell receptor.
Microbiology and immunology 1991;35(7):493-506.

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