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Yasunobu Yoshikai

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Koji Sakuraba; Kensuke Shibata; Yukihide Iwamoto; Yasunobu Yoshikai; Hisakata Yamada
Naturally occurring PD-1+ memory phenotype CD8 T cells belong to nonconventional CD8 T cells and are cyclophosphamide-sensitive regulatory T cells.
Shinji Okano; Ken Shirabe; Yuji Soejima; Takeo Toshima; Yasunobu Yoshikai; Tomoharu Yoshizumi; Mamoru Harada; Haruhiko Kondoh; Hidekazu Nakagawara; Yoshihiko Maehara
Fas-deficient fully allogeneic dendritic cells administered via an intratumoral injection route show efficient antitumor effects in murine models.
Shinji Okano; Ken Shirabe; Yo-ichi Yamashita; Yasunobu Yoshikai; Shohei Yoshiya; Mamoru Harada; Norifumi Harimoto; Toru Ikegami; Yoshihiro Matsumoto; Yoshihiko Maehara
CD4 T cell-mediated masking effects of the immunogenicity of tumor-associated antigens are qualitatively and quantitatively different depending on the individual antigens.

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2013: Koji Sakuraba; Kensuke Shibata; Yukihide Iwamoto; Yasunobu Yoshikai; Hisakata Yamada
Naturally occurring PD-1+ memory phenotype CD8 T cells belong to nonconventional CD8 T cells and are cyclophosphamide-sensitive regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(4):1560-6.
2013: Shinji Okano; Ken Shirabe; Yuji Soejima; Takeo Toshima; Yasunobu Yoshikai; Tomoharu Yoshizumi; Mamoru Harada; Haruhiko Kondoh; Hidekazu Nakagawara; Yoshihiko Maehara
Fas-deficient fully allogeneic dendritic cells administered via an intratumoral injection route show efficient antitumor effects in murine models.
Fukuoka igaku zasshi = Hukuoka acta medica 2013;104(1):15-26.
2013: Shinji Okano; Ken Shirabe; Yo-ichi Yamashita; Yasunobu Yoshikai; Shohei Yoshiya; Mamoru Harada; Norifumi Harimoto; Toru Ikegami; Yoshihiro Matsumoto; Yoshihiko Maehara
CD4 T cell-mediated masking effects of the immunogenicity of tumor-associated antigens are qualitatively and quantitatively different depending on the individual antigens.
Fukuoka igaku zasshi = Hukuoka acta medica 2013;104(1):1-14.
2012: Yojiro Arimori; Yoshitaka Hirose; Hiroshi Ichikawa; Shinji Murosaki; Risa Nakamura; Osamu Shidara; Yoshihiro Yamamoto; Yasunobu Yoshikai
Daily intake of heat-killed Lactobacillus plantarum L-137 enhances type I interferon production in healthy humans and pigs.
Immunopharmacology and immunotoxicology 2012;34(6):937-43.
2012: Shinichi Somada; Xun Sun; Ryoichi Takayanagi; Hirotada Akiho; Kuniomi Honda; Eikichi Ihara; Hiromi Muta; Kazuhiko Nakamura; Eckhard R Podack; Yasunobu Yoshikai; Kenzaburo Tani
CD30 ligand/CD30 interaction is involved in pathogenesis of inflammatory bowel disease.
Digestive diseases and sciences 2012;57(8):2031-7.
2011: Takashi Dejima; Hiromitsu Hara; Yoichiro Iwakura; Seiji Naito; Kensuke Shibata; Hisakata Yamada; Yasunobu Yoshikai
Protective role of naturally occurring interleukin-17A-producing γδ T cells in the lung at the early stage of systemic candidiasis in mice.
Infection and immunity 2011;79(11):4503-10.
2011: Takafumi Fuchiwaki; Kenjiro Fujimura; Hideyuki Kawauchi; Hiromi Muta; Eckhard R Podack; Kensuke Shibata; Xun Sun; Hisakata Yamada; Yasunobu Yoshikai
The central role of CD30L/CD30 interactions in allergic rhinitis pathogenesis in mice.
European journal of immunology 2011;41(10):2947-54.
2011: Kenji Umeda; Hisakata Yamada; Ying Guo; Kensuke Shibata; Xun Sun; Yasunobu Yoshikai
Innate memory phenotype CD4+ T cells play a role in early protection against infection by Listeria monocytogenes in a CD30L-dependent manner.
Microbiology and immunology 2011;55(9):645-56.
2011: Kensuke Shibata; Hiroyuki Toh; Hisakata Yamada; Sho Yamasaki; Takashi Dejima; Hiromitsu Hara; Tomokatsu Ikawa; Yoichiro Iwakura; Ryoichiro Kageyama; Hiroshi Kawamoto; Masataka Nakamura; Tetsuya Sato; Yasunobu Yoshikai
Notch-Hes1 pathway is required for the development of IL-17-producing γδ T cells.
Blood 2011;118(3):586-93.
2011: Yasunobu Yoshikai
[Studies of T cells for better understanding of immunity and allergy].
Nihon Jibiinkoka Gakkai kaiho 2011;114(6):539-46.
2011: Shinji Okano; Yoshikazu Yonemitsu; Ken Shirabe; Yoshihiro Kakeji; Yoshihiko Maehara; Mamoru Harada; Yasunobu Yoshikai; Makoto Inoue; Mamoru Hasegawa; Katsuo Sueishi
Provision of continuous maturation signaling to dendritic cells by RIG-I-stimulating cytosolic RNA synthesis of Sendai virus.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(3):1828-39.
2011: Ario Takeuchi; Takashi Dejima; Hisakata Yamada; Kensuke Shibata; Risa Nakamura; Masatoshi Eto; Tatsuya Nakatani; Seiji Naito; Yasunobu Yoshikai
IL-17 production by γδ T cells is important for the antitumor effect of Mycobacterium bovis bacillus Calmette-Guérin treatment against bladder cancer.
European journal of immunology 2011;41(1):246-51.
2010: Xun Sun; Hisakata Yamada; Kensuke Shibata; Hiromi Muta; Kenzaburo Tani; Eckhard R Podack; Yoichiro Iwakura; Yasunobu Yoshikai
CD30 ligand is a target for a novel biological therapy against colitis associated with Th17 responses.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(12):7671-80.
2010: H Kondoh; Shinji Okano; K Yoshida; Yoshikazu Yonemitsu; Yukihiro Tomita; Yasunobu Yoshikai; Norio Wake; Katsuo Sueishi
Semi-allogeneic dendritic cells injected via the intratumoural injection route show efficient antitumour effects in cooperation with host-derived professional antigen-presenting cells.
Scandinavian journal of immunology 2010;72(6):476-90.
2010: Ario Takeuchi; Masatoshi Eto; Katsunori Tatsugami; Hisakata Yamada; Toshihiro Oki; Keijiro Kiyoshima; Yasunobu Yoshikai; Seiji Naito
Mechanism of synergistic antitumor effect of sorafenib and interferon-α on treatment of renal cell carcinoma.
The Journal of urology 2010;184(6):2549-56.
2010: Xun Sun; Hisakata Yamada; Kensuke Shibata; Hiromi Muta; Kenzaburo Tani; Eckhard R Podack; Yasunobu Yoshikai
CD30 ligand/CD30 plays a critical role in Th17 differentiation in mice.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(4):2222-30.
2010: Tatsushi Onzuka; Yukihiro Tomita; Shinji Okano; Ichiro Shimizu; Hisakata Yamada; Yasunobu Yoshikai; Ryuji Tominaga
Antibody-mediated T-cell reduction or increased levels of chimerism overcome resistance to cyclophosphamide-induced tolerance in NKT-deficient mice.
Scandinavian journal of immunology 2010;72(2):106-17.
2010: Risa Nakamura; Naoyoshi Maeda; Kensuke Shibata; Hisakata Yamada; Tetsuo Kase; Yasunobu Yoshikai
Interleukin-15 is critical in the pathogenesis of influenza a virus-induced acute lung injury.
Journal of virology 2010;84(11):5574-82.
2010: Kazuhito Gotoh; Yoshihiko Tanaka; Akihiko Nishikimi; Risa Nakamura; Hisakata Yamada; Naoyoshi Maeda; Takahiro Ishikawa; Katsuaki Hoshino; Takehito Uruno; Qinhong Cao; Sadayuki Higashi; Yasushi Kawaguchi; Munechika Enjoji; Ryoichi Takayanagi; Tsuneyasu Kaisho; Yasunobu Yoshikai; Yoshinori Fukui
Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation.
The Journal of experimental medicine 2010;207(4):721-30.
2010: Yoshitaka Hirose; Shinji Murosaki; Takashi Fujiki; Yoshihiro Yamamoto; Yasunobu Yoshikai; Mitsuo Yamashita
Lipoteichoic acids on Lactobacillus plantarum cell surfaces correlate with induction of interleukin-12p40 production.
Microbiology and immunology 2010;54(3):143-51.
2010: Shino Kumabe; Momoe Itsumi; Hisakata Yamada; Toshiki Yajima; Tetsuya Matsuguchi; Yasunobu Yoshikai
Dual specificity phosphatase16 is a negative regulator of c-Jun NH2-terminal kinase activity in T cells.
Microbiology and immunology 2010;54(2):105-11.
2010: Naoyoshi Maeda; Hiromi Muta; Ezogelin Oflazoglu; Yasunobu Yoshikai
Susceptibility of human T-cell leukemia virus type I-infected cells to humanized anti-CD30 monoclonal antibodies in vitro and in vivo.
Cancer science 2010;101(1):224-30.
2009: Eri Ishikawa; Tetsuaki Ishikawa; Yasu S Morita; Kenji Toyonaga; Hisakata Yamada; Osamu Takeuchi; Taroh Kinoshita; Shizuo Akira; Yasunobu Yoshikai; Sho Yamasaki
Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle.
The Journal of experimental medicine 2009;206(13):2879-88.
2009: Akiko Oyamada; Hiori Ikebe; Momoe Itsumi; Hirokazu Saiwai; Seiji Okada; Kazuya Shimoda; Yoichiro Iwakura; Keiichi I Nakayama; Yukihide Iwamoto; Yasunobu Yoshikai; Hisakata Yamada
Tyrosine kinase 2 plays critical roles in the pathogenic CD4 T cell responses for the development of experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(11):7539-46.
2009: Ario Takeuchi; Yoriyuki Kamiryou; Hisakata Yamada; Masatoshi Eto; Kensuke Shibata; Kennichi Haruna; Seiji Naito; Yasunobu Yoshikai
Oral administration of xanthan gum enhances antitumor activity through Toll-like receptor 4.
International immunopharmacology 2009;9(13-14):1562-7.
2009: Tatsushi Onzuka; Yukihiro Tomita; Ichiro Shimizu; Shinji Okano; Hisakata Yamada; Yasunobu Yoshikai; Ryuji Tominaga
Effects of lipopolysaccharide on the induction of mixed chimerism in cyclophosphamide-induced tolerance.
Scandinavian journal of immunology 2009;70(5):423-30.
2009: Takahiro Ishikawa; Hisakata Yamada; Akiko Oyamada; Fumi Goshima; Yukihiro Nishiyama; Yasunobu Yoshikai
Protective role of Fas-FasL signaling in lethal infection with herpes simplex virus type 2 in mice.
Journal of virology 2009;83(22):11777-83.
2009: Naoyoshi Maeda; Risa Nakamura; Yoshitaka Hirose; Shinji Murosaki; Yoshihiro Yamamoto; Tetsuo Kase; Yasunobu Yoshikai
Oral administration of heat-killed Lactobacillus plantarum L-137 enhances protection against influenza virus infection by stimulation of type I interferon production in mice.
International immunopharmacology 2009;9(9):1122-5.
2009: Momoe Itsumi; Yasunobu Yoshikai; Hisakata Yamada
IL-15 is critical for the maintenance and innate functions of self-specific CD8(+) T cells.
European journal of immunology 2009;39(7):1784-93.
2009: Ce Tang; Hisakata Yamada; Kensuke Shibata; Shin-Ichi Yoshida; Worawidh Wajjwalku; Yasunobu Yoshikai
IL-15 protects antigen-specific CD8+ T cell contraction after Mycobacterium bovis bacillus Calmette-Guérin infection.
Journal of leukocyte biology 2009;86(1):187-94.
2009: Yoriyuki Kamiryo; Masatoshi Eto; Hisakata Yamada; Toshiki Yajima; Masahiko Harano; Ario Takeuchi; Katsunori Tatsugami; Masumitsu Hamaguchi; Seiji Naito; Yasunobu Yoshikai
Donor CD4 T cells are critical in allogeneic stem cell transplantation against murine solid tumor.
Cancer research 2009;69(12):5151-8.
2009: Yasunobu Yoshikai
[Immunological protection against Mycobacterium tuberculosis infection].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2009;54(8 Suppl):1014-9.
2009: Yukari Shinozaki; Sen Wang; Yoshiyuki Miyazaki; Kohji Miyazaki; Hisakata Yamada; Yasunobu Yoshikai; Hiromitsu Hara; Hiroki Yoshida
Tumor-specific cytotoxic T cell generation and dendritic cell function are differentially regulated by interleukin 27 during development of anti-tumor immunity.
International journal of cancer. Journal international du cancer 2009;124(6):1372-8.
2009: Masumitsu Hamaguchi; Masatoshi Eto; Yoriyuki Kamiryo; Ario Takeuchi; Masahiko Harano; Katsunori Tatsugami; Takanori Teshima; Mamoru Harada; Yasunobu Yoshikai; Seiji Naito
Allogeneic cell therapy from immunized donors with tumor antigen peptide enhances the antitumor effect after cyclophosphamide-using non-myeloablative allogeneic hematopoietic cell transplantation.
Cancer science 2009;100(1):138-43.
2008: Hiroyuki Saiga; Junichi Nishimura; Hirotaka Kuwata; Megumi Okuyama; Sohkichi Matsumoto; Shintaro Sato; Makoto Matsumoto; Shizuo Akira; Yasunobu Yoshikai; Kenya Honda; Masahiro Yamamoto; Kiyoshi Takeda
Lipocalin 2-dependent inhibition of mycobacterial growth in alveolar epithelium.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(12):8521-7.
2008: Tatsushi Onzuka; Yukihiro Tomita; Ichiro Shimizu; Shinji Okano; Hisakata Yamada; Yasunobu Yoshikai; Ryuji Tominaga
Role of the cytokine profiles produced by invariant natural killer T cells in the initial phase of cyclophosphamide-induced tolerance.
Transplantation 2008;86(9):1301-10.
2008: Ce Tang; Hisakata Yamada; Kensuke Shibata; Hiromi Muta; Worawidh Wajjwalku; Eckhard R Podack; Yasunobu Yoshikai
A novel role of CD30L/CD30 signaling by T-T cell interaction in Th1 response against mycobacterial infection.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(9):6316-27.
2008: Seyed Fazlollah Mousavi; Pejman Soroosh; Takeshi Takahashi; Yasunobu Yoshikai; Hao Shen; Leo Lefrançois; Jannie Borst; Kazuo Sugamura; Naoto Ishii
OX40 costimulatory signals potentiate the memory commitment of effector CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(9):5990-6001.
2008: Kensuke Shibata; Hisakata Yamada; Risa Nakamura; Xun Sun; Momoe Itsumi; Yasunobu Yoshikai
Identification of CD25+ gamma delta T cells as fetal thymus-derived naturally occurring IL-17 producers.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(9):5940-7.
2008: Naoyoshi Maeda; Hung Fan; Yasunobu Yoshikai
Oncogenesis by retroviruses: old and new paradigms.
Reviews in medical virology 2008;18(6):387-405.
2008: Yu Hikosaka; Takeshi Nitta; Izumi Ohigashi; Kouta Yano; Naozumi Ishimaru; Yoshio Hayashi; Mitsuru Matsumoto; Koichi Matsuo; Josef M Penninger; Hiroshi Takayanagi; Yoshifumi Yokota; Hisakata Yamada; Yasunobu Yoshikai; Jun-Ichiro Inoue; Taishin Akiyama; Yousuke Takahama
The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.
Immunity 2008;29(3):438-50.
2008: Hisakata Yamada; Yutaka Nakashima; Ken Okazaki; Taro Mawatari; J-I Fukushi; N Kaibara; A Hori; Yukihide Iwamoto; Yasunobu Yoshikai
Th1 but not Th17 cells predominate in the joints of patients with rheumatoid arthritis.
Annals of the rheumatic diseases 2008;67(9):1299-304.
2008: Risa Nakamura; Kensuke Shibata; Hisakata Yamada; Kazuya Shimoda; Keiichi Nakayama; Yasunobu Yoshikai
Tyk2-signaling plays an important role in host defense against Escherichia coli through IL-23-induced IL-17 production by gammadelta T cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(3):2071-5.
2008: Masatoshi Eto; Yoriyuki Kamiryo; Ario Takeuchi; Masahiko Harano; Katsunori Tatsugami; Mamoru Harada; Keijiro Kiyoshima; Masumitsu Hamaguchi; Takanori Teshima; Masazumi Tsuneyoshi; Yasunobu Yoshikai; Seiji Naito
Posttransplant administration of cyclophosphamide and donor lymphocyte infusion induces potent antitumor immunity to solid tumor.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(9):2833-40.
2008: Ce Tang; Hisakata Yamada; Kensuke Shibata; Naoyoshi Maeda; Shinichi Yoshida; Worawidh Wajjwalku; Naoya Ohara; Takeshi Yamada; Taroh Kinoshita; Yasunobu Yoshikai
Efficacy of recombinant bacille Calmette-Guérin vaccine secreting interleukin-15/antigen 85B fusion protein in providing protection against Mycobacterium tuberculosis.
The Journal of infectious diseases 2008;197(9):1263-74.
2008: Junichi Nishimura; Hiroyuki Saiga; Shintaro Sato; Megumi Okuyama; Hisako Kayama; Hirotaka Kuwata; Sohkichi Matsumoto; Toshirou Nishida; Yoshiki Sawa; Shizuo Akira; Yasunobu Yoshikai; Masahiro Yamamoto; Kiyoshi Takeda
Potent antimycobacterial activity of mouse secretory leukocyte protease inhibitor.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(6):4032-9.
2008: Xun Sun; Shinichi Somada; Kensuke Shibata; Hiromi Muta; Hisakata Yamada; Hirofumi Yoshihara; Kuniomi Honda; Kazuhiko Nakamura; Ryhoichi Takayanagi; Kenzaburo Tani; Eckhard R Podack; Yasunobu Yoshikai
A critical role of CD30 ligand/CD30 in controlling inflammatory bowel diseases in mice.
Gastroenterology 2008;134(2):447-58.
2008: Yoshiko Kagimoto; Hisakata Yamada; Takahiro Ishikawa; Naoyoshi Maeda; Fumi Goshima; Yukihiro Nishiyama; masutaka furue; Yasunobu Yoshikai
A regulatory role of interleukin 15 in wound healing and mucosal infection in mice.
Journal of leukocyte biology 2008;83(1):165-72.
2007: Toshiro Iwai; Yukihiro Tomita; Ichiro Shimizu; Takashi Kajiwara; Tatsushi Onzuka; Shinji Okano; Yohichi Yasunami; Yasunobu Yoshikai; Kikuo Nomoto; Ryuji Tominaga
The immunoregulatory roles of natural killer T cells in cyclophosphamide-induced tolerance.
Transplantation 2007;84(12):1686-95.
2007: Naoyoshi Maeda; Yasunobu Yoshikai
[New molecular mechanisms of virus-mediated carcinogenesis: oncogenic transformation of cells by retroviral structural protein Envelope].
Uirusu 2007;57(2):159-70.
2007: Kazufumi Yoshihara; Hisakata Yamada; Akiko Hori; Toshiki Yajima; Chiharu Kubo; Yasunobu Yoshikai
IL-15 exacerbates collagen-induced arthritis with an enhanced CD4+ T cell response to produce IL-17.
European journal of immunology 2007;37(10):2744-52.
2007: Norika Chiba; Akio Masuda; Yasunobu Yoshikai; Tetsuya Matsuguchi
Ceramide inhibits LPS-induced production of IL-5, IL-10, and IL-13 from mast cells.
Journal of cellular physiology 2007;213(1):126-36.
2007: Xun Sun; Hisakata Yamada; Kazufumi Yoshihara; Akira Awaya; Yasunobu Yoshikai
In vivo treatment with a nonapeptide thymic hormone, facteur thymique serique (FTS), ameliorates chronic colitis induced by dextran sulphate sodium in mice.
International immunopharmacology 2007;7(7):928-36.
2007: Wei Li; Hisakata Yamada; Toshiki Yajima; Ryusuke Nakagawa; Kazuya Shimoda; Keiichi Nakayama; Yasunobu Yoshikai
Tyk2 signaling in host environment plays an important role in contraction of antigen-specific CD8+ T cells following a microbial infection.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(7):4482-8.
2007: Kensuke Shibata; Hisakata Yamada; Hiromitsu Hara; Kenji Kishihara; Yasunobu Yoshikai
Resident Vdelta1+ gammadelta T cells control early infiltration of neutrophils after Escherichia coli infection via IL-17 production.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(7):4466-72.
2007: Takehiko Doi; Hisakata Yamada; Toshiki Yajima; Worawidh Wajjwalku; Toshiro Hara; Yasunobu Yoshikai
H2-M3-restricted CD8+ T cells induced by peptide-pulsed dendritic cells confer protection against Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(6):3806-13.
2007: Yasunobu Yoshikai
[Roles of natural memory lymphocytes in host defense mechanisms].
Nihon rinsho. Japanese journal of clinical medicine 2007;65 Suppl 2 Pt. 1():109-12.
2007: Masatoshi Eto; Masahiko Harano; Katsunori Tatsugami; Mamoru Harada; Yoriyuki Kamiryo; Keijiro Kiyoshima; Masumitsu Hamaguchi; Masazumi Tsuneyoshi; Yasunobu Yoshikai; Seiji Naito
Cyclophosphamide-using nonmyeloablative allogeneic cell therapy against renal cancer with a reduced risk of graft-versus-host disease.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(3):1029-35.
2007: Takashi Kajiwara; Yukihiro Tomita; Shinji Okano; Toshiro Iwai; Yohichi Yasunami; Yasunobu Yoshikai; Kikuo Nomoto; Hisataka Yasui; Ryuji Tominaga
Effects of cyclosporin A on the activation of natural killer T cells induced by alpha-galactosylceramide.
Transplantation 2007;83(2):184-92.
2007: Kenji Nakazato; Hisakata Yamada; Toshiki Yajima; Yoshiko Kagimoto; Hiroyuki Kuwano; Yasunobu Yoshikai
Enforced expression of Bcl-2 partially restores cell numbers but not functions of TCRgammadelta intestinal intraepithelial T lymphocytes in IL-15-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(2):757-64.
2006: Toshiro Iwai; Yukihiro Tomita; Shinji Okano; Ichiro Shimizu; Yohichi Yasunami; Takashi Kajiwara; Yasunobu Yoshikai; Masaru Taniguchi; Kikuo Nomoto; Hisataka Yasui
Regulatory roles of NKT cells in the induction and maintenance of cyclophosphamide-induced tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(12):8400-9.
2006: Yoshitaka Hirose; Shinji Murosaki; Yoshihiro Yamamoto; Yasunobu Yoshikai; Tomomi Tsuru
Daily intake of heat-killed Lactobacillus plantarum L-137 augments acquired immunity in healthy adults.
The Journal of nutrition 2006;136(12):3069-73.
2006: Keiji Aizu; Wei Li; Toshiki Yajima; Toshiyuki Arai; Kazuya Shimoda; Yuji Nimura; Yasunobu Yoshikai
An important role of Tyk2 in APC function of dendritic cells for priming CD8+ T cells producing IFN-gamma.
European journal of immunology 2006;36(11):3060-70.
2006: Shigeyuki Nagata; Shinji Okano; Yoshikazu Yonemitsu; Kazunori Nakagawa; Yukihiro Tomita; Yasunobu Yoshikai; Mitsuo Shimada; Yoshihiko Maehara; Katsuo Sueishi
Critical roles of memory T cells and antidonor immunoglobulin in rejection of allogeneic bone marrow cells in sensitized recipient mice.
Transplantation 2006;82(5):689-98.
2006: Yasunobu Yoshikai
[Crosstalk between innate and adaptive immunity].
Nihon rinsho. Japanese journal of clinical medicine 2006;64(7):1223-8.
2006: Noriaki Aoi; Tokuko Masuda; Daisuke Murakami; Toshiki Yajima; Hiroyuki Mizubuchi; Hisakata Yamada; Hideyuki Kawauchi; Yasunobu Yoshikai
IL-15 prevents allergic rhinitis through reactivation of antigen-specific CD8+ cells.
The Journal of allergy and clinical immunology 2006;117(6):1359-66.
2006: Qingsheng Yu; Ce Tang; Sun Xun; Toshiki Yajima; Kiyoshi Takeda; Yasunobu Yoshikai
MyD88-dependent signaling for IL-15 production plays an important role in maintenance of CD8 alpha alpha TCR alpha beta and TCR gamma delta intestinal intraepithelial lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(10):6180-5.
2006: Yoshiko Kagimoto; Yasunobu Yoshikai
[Immune response against HSV].
Nihon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 3():178-83.
2006: Kazufumi Yoshihara; Toshiki Yajima; Chiharu Kubo; Yasunobu Yoshikai
Role of interleukin 15 in colitis induced by dextran sulphate sodium in mice.
Gut 2006;55(3):334-41.
2006: Kimika Saito; Toshiki Yajima; Shino Kumabe; Takehiko Doi; Hisakata Yamada; subash sad; Hao Shen; Yasunobu Yoshikai
Impaired protection against Mycobacterium bovis bacillus Calmette-Guerin infection in IL-15-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(4):2496-504.
2006: Vahid Khajoee; M Saito; Hidetoshi Takada; Akihiko Nomura; Koichi Kusuhara; S-I Yoshida; Yasunobu Yoshikai; Toshiro Hara
Novel roles of osteopontin and CXC chemokine ligand 7 in the defence against mycobacterial infection.
Clinical and experimental immunology 2006;143(2):260-8.
2006: Yasunobu Yoshikai
Immunological protection against mycobacterium tuberculosis infection.
Critical reviews in immunology 2006;26(6):515-26.
2006: Toshiki Yajima; Kazufumi Yoshihara; Kenji Nakazato; Shino Kumabe; Shigeo Koyasu; subash sad; Hao Shen; Hiroyuki Kuwano; Yasunobu Yoshikai
IL-15 regulates CD8+ T cell contraction during primary infection.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(1):507-15.
2006: A Ogawa; T Tagawa; Hitoshi Nishimura; Toshiki Yajima; T Abe; T Arai; M Taniguchi; Kiyoshi Takeda; Shizuo Akira; Yuji Nimura; Yasunobu Yoshikai
Toll-like receptors 2 and 4 are differentially involved in Fas dependent apoptosis in Peyer's patch and the liver at an early stage after bile duct ligation in mice.
Gut 2006;55(1):105-13.
2005: Hiroyuki Mizubuchi; Toshiki Yajima; Noriaki Aoi; Tetsuji Tomita; Yasunobu Yoshikai
Isomalto-oligosaccharides polarize Th1-like responses in intestinal and systemic immunity in mice.
The Journal of nutrition 2005;135(12):2857-61.
2005: Masahiko Harano; Masatoshi Eto; Toshiro Iwai; Katsunori Tatsugami; Keijiro Kiyoshima; Yoriyuki Kamiryo; Masazumi Tsuneyoshi; Yasunobu Yoshikai; Seiji Naito
Renal cancer treatment with low levels of mixed chimerism induced by nonmyeloablative regimen using cyclophosphamide in mice.
Cancer research 2005;65(21):10032-40.
2005: Hitoshi Nishimura; Toshiki Yajima; Hiromi Muta; Eckhard R Podack; Kenzaburo Tani; Yasunobu Yoshikai
A novel role of CD30/CD30 ligand signaling in the generation of long-lived memory CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(7):4627-34.
2005: Yoriyuki Kamiryo; Toshiki Yajima; Kimika Saito; Hitoshi Nishimura; Takashi Fushimi; Yoshifumi Ohshima; Yoshinori Tsukamoto; Seiji Naito; Yasunobu Yoshikai
Soluble branched (1,4)-beta-D-glucans from Acetobacter species enhance antitumor activities against MHC class I-negative and -positive malignant melanoma through augmented NK activity and cytotoxic T-cell response.
International journal of cancer. Journal international du cancer 2005;115(5):769-76.
2005: Hitoshi Nishimura; Yasunobu Yoshikai
[Development of vaccine and its immunological mechanism].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 5():585-9.
2005: Tetsuzo Tagawa; Yasunobu Yoshikai
[Gamma-delta T cells].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 4():149-53.
2005: Toshiki Yajima; Hitoshi Nishimura; subash sad; Hao Shen; Hiroyuki Kuwano; Yasunobu Yoshikai
A novel role of IL-15 in early activation of memory CD8+ CTL after reinfection.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(6):3590-7.
2005: Yasuko Yoshioka; Satsuki Kudo; Hitoshi Nishimura; Toshiki Yajima; Kenji Kishihara; Kimika Saito; Tatsuo Suzuki; Yumiko Suzuki; Shinsuke Kuroiwa; Yasunobu Yoshikai
Oral administration of bovine colostrum stimulates intestinal intraepithelial lymphocytes to polarize Th1-type in mice.
International immunopharmacology 2005;5(3):581-90.
2005: Tipayaratn Musikacharoen; Asako Oguma; Yasunobu Yoshikai; Norika Chiba; Akio Masuda; Tetsuya Matsuguchi
Interleukin-15 induces IL-12 receptor beta1 gene expression through PU.1 and IRF 3 by targeting chromatin remodeling.
Blood 2005;105(2):711-20.
2005: Masatoshi Eto; Hirofumi Koga; Hideya Noma; Akito Yamaguchi; Yasunobu Yoshikai; Seiji Naito
Importance of urinary interleukin-18 in intravesical immunotherapy with bacillus calmette-guérin for superficial bladder tumors.
Urologia internationalis 2005;75(2):114-8.
2005: Hitoshi Nishimura; Atsushi Fujimoto; Naoyuki Tamura; Toshiki Yajima; Worawidh Wajjwalku; Yasunobu Yoshikai
A novel autoregulatory mechanism for transcriptional activation of the IL-15 gene by a nonsecretable isoform of IL-15 generated by alternative splicing.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(1):19-28.
2004: Wei Li; Toshiki Yajima; Kimika Saito; Hitoshi Nishimura; Takashi Fushimi; Yoshifumi Ohshima; Yoshinori Tsukamoto; Yasunobu Yoshikai
Immunostimulating properties of intragastrically administered Acetobacter-derived soluble branched (1,4)-beta-D-glucans decrease murine susceptibility to Listeria monocytogenes.
Infection and immunity 2004;72(12):7005-11.
2004: Akio Masuda; Yasunobu Yoshikai; Hiroaki Kume; Tetsuya Matsuguchi
The interaction between GATA proteins and activator protein-1 promotes the transcription of IL-13 in mast cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(9):5564-73.
2004: Tetsuzo Tagawa; Hitoshi Nishimura; Toshiki Yajima; Hiromitsu Hara; Kenji Kishihara; Goro Matsuzaki; Ichiro Yoshino; Yoshihiko Maehara; Yasunobu Yoshikai
Vdelta1+ gammadelta T cells producing CC chemokines may bridge a gap between neutrophils and macrophages in innate immunity during Escherichia coli infection in mice.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(8):5156-64.
2004: Ryosuke Minagawa; Shinji Okano; Yukihiro Tomita; Kenji Kishihara; Hisakata Yamada; Kikuo Nomoto; Mitsuo Shimada; Yoshihiko Maehara; Keizo Sugimachi; Yasunobu Yoshikai; Kikuo Nomoto
The critical role of Fas-Fas ligand interaction in donor-specific transfusion-induced tolerance to H-Y antigen.
Transplantation 2004;78(6):799-806.
2004: Kenji Sugimoto; Mutsuhiro Ohata; Jun Miyoshi; Hiroyoshi Ishizaki; Naotake Tsuboi; Akio Masuda; Yasunobu Yoshikai; Masaya Takamoto; Kazuo Sugane; Seiichi Matsuo; Yasuhiro Shimada; Tetsuya Matsuguchi
A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation.
The Journal of clinical investigation 2004;114(6):857-66.
2004: Tetsuya Abe; Toshiyuki Arai; Atsushi Ogawa; Takashi Hiromatsu; Akio Masuda; Tetsuya Matsuguchi; Yuji Nimura; Yasunobu Yoshikai
Kupffer cell-derived interleukin 10 is responsible for impaired bacterial clearance in bile duct-ligated mice.
Hepatology (Baltimore, Md.) 2004;40(2):414-23.
2004: Toshiki Yajima; Hitoshi Nishimura; Kimika Saito; Hiroyuki Kuwano; Yasunobu Yoshikai
Overexpression of Interleukin-15 increases susceptibility to lipopolysaccharide-induced liver injury in mice primed with Mycobacterium bovis bacillus Calmette-Guerin.
Infection and immunity 2004;72(7):3855-62.
2004: Hitoshi Nishimura; Toshiki Yajima; Yoshiko Kagimoto; Mutsuhiro Ohata; Taketo Watase; Kenji Kishihara; Fumi Goshima; Yukihiro Nishiyama; Yasunobu Yoshikai
Intraepithelial gammadelta T cells may bridge a gap between innate immunity and acquired immunity to herpes simplex virus type 2.
Journal of virology 2004;78(9):4927-30.
2003: Kimika Saito; Toshiki Yajima; Hitoshi Nishimura; Keiko Aiba; Ryotaro Ishimitsu; Tetsuya Matsuguchi; Takashi Fushimi; Yoshifumi Ohshima; Yoshinori Tsukamoto; Yasunobu Yoshikai
Soluble branched beta-(1,4)glucans from Acetobacter species show strong activities to induce interleukin-12 in vitro and inhibit T-helper 2 cellular response with immunoglobulin E production in vivo.
The Journal of biological chemistry 2003;278(40):38571-8.
2003: Tetsuya Matsuguchi; Akio Masuda; Kenji Sugimoto; Yoshiyuki Nagai; Yasunobu Yoshikai
JNK-interacting protein 3 associates with Toll-like receptor 4 and is involved in LPS-mediated JNK activation.
The EMBO journal 2003;22(17):4455-64.
2003: Takashi Hiromatsu; Tetsuya Matsuguchi; Hideyuki Shimizu; Toshiki Yajima; Hitoshi Nishimura; Toshiyuki Arai; Yuji Nimura; Yasunobu Yoshikai
NK T cells stimulated with a ligand for TLR2 at least partly contribute to liver injury caused by Escherichia coli infection in mice.
European journal of immunology 2003;33(9):2511-9.
2003: Takeshi Kikuchi; Yasunobu Yoshikai; J Miyoshi; M Katsuki; Tipayaratn Musikacharoen; Akio Mitani; S Tanaka; Toshihide Noguchi; Tetsuya Matsuguchi
Cot/Tpl2 is essential for RANKL induction by lipid A in osteoblasts.
Journal of dental research 2003;82(7):546-50.
2003: Takashi Hiromatsu; Toshiki Yajima; Tetsuya Matsuguchi; Hitoshi Nishimura; Worawidh Wajjwalku; Toshiyuki Arai; Yuji Nimura; Yasunobu Yoshikai
Overexpression of interleukin-15 protects against Escherichia coli-induced shock accompanied by inhibition of tumor necrosis factor-alpha-induced apoptosis.
The Journal of infectious diseases 2003;187(9):1442-51.
2003: Tipayaratn Musikacharoen; Yasunobu Yoshikai; Tetsuya Matsuguchi
Histone acetylation and activation of cAMP-response element-binding protein regulate transcriptional activation of MKP-M in lipopolysaccharide-stimulated macrophages.
The Journal of biological chemistry 2003;278(11):9167-75.
2003: Tetsuya Matsuguchi; Akimitsu Takagi; Takeshi Matsuzaki; Masato Nagaoka; Kimika Ishikawa; Teruo Yokokura; Yasunobu Yoshikai
Lipoteichoic acids from Lactobacillus strains elicit strong tumor necrosis factor alpha-inducing activities in macrophages through Toll-like receptor 2.
Clinical and diagnostic laboratory immunology 2003;10(2):259-66.
2003: Ryotaro Ishimitsu; Toshiki Yajima; Hitoshi Nishimura; Hideyuki Kawauchi; Yasunobu Yoshikai
NKT cells are dispensable in the induction of oral tolerance but are indispensable in the abrogation of oral tolerance by prostaglandin E.
European journal of immunology 2003;33(1):183-93.
2002: Tie Liu; Tetsuya Matsuguchi; Naotake Tsuboi; Toshiki Yajima; Yasunobu Yoshikai
Differences in expression of toll-like receptors and their reactivities in dendritic cells in BALB/c and C57BL/6 mice.
Infection and immunity 2002;70(12):6638-45.
2002: Masayuki Umemura; Hitoshi Nishimura; Toshiki Yajima; Worawid Wajjwalk; Tetsuya Matsuguchi; Masahide Takahashi; Yukihiro Nishiyama; Masahiko Makino; Yoshiyuki Nagai; Yasunobu Yoshikai
Overexpression of interleukin-15 prevents the development of murine retrovirus-induced acquired immunodeficiency syndrome.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(13):1755-63.
2002: Hideyuki Shimizu; Tetsuya Matsuguchi; Yoshihide Fukuda; Isao Nakano; Tetsuo Hayakawa; Osamu Takeuchi; Shizuo Akira; Masayuki Umemura; Takashi Suda; Yasunobu Yoshikai
Toll-like receptor 2 contributes to liver injury by Salmonella infection through Fas ligand expression on NKT cells in mice.
Gastroenterology 2002;123(4):1265-77.
2002: Akio Masuda; Yasunobu Yoshikai; Keiko Aiba; Tetsuya Matsuguchi
Th2 cytokine production from mast cells is directly induced by lipopolysaccharide and distinctly regulated by c-Jun N-terminal kinase and p38 pathways.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(7):3801-10.
2002: Naotake Tsuboi; Yasunobu Yoshikai; Seiichi Matsuo; Takeshi Kikuchi; Ken-Ichiro Iwami; Yoshiyuki Nagai; Osamu Takeuchi; Shizuo Akira; Tetsuya Matsuguchi
Roles of toll-like receptors in C-C chemokine production by renal tubular epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(4):2026-33.
2002: Toshiki Yajima; Hitoshi Nishimura; Worawidh Wajjwalku; Mamoru Harada; Hiroyuki Kuwano; Yasunobu Yoshikai
Overexpression of interleukin-15 in vivo enhances antitumor activity against MHC class I-negative and -positive malignant melanoma through augmented NK activity and cytotoxic T-cell response.
International journal of cancer. Journal international du cancer 2002;99(4):573-8.
2002: Naoto Itoh; Hitoshi Nishimura; Tetsuya Matsuguchi; Toshiki Yajima; Yasuji Mokuno; Takashi Hiromatsu; Yuji Nimura; Yasunobu Yoshikai
CD8 alpha-deficient mice are highly susceptible to 5-fluorouracil-induced lethality.
Clinical and diagnostic laboratory immunology 2002;9(3):550-7.
2002: Goro Matsuzaki; Hisakata Yamada; Kenji Kishihara; Yasunobu Yoshikai; Kikuo Nomoto
Mechanism of murine Vgamma1+ gamma delta T cell-mediated innate immune response against Listeria monocytogenes infection.
European journal of immunology 2002;32(4):928-35.
2002: Toshiki Yajima; Hitoshi Nishimura; Ryotaro Ishimitsu; Taketo Watase; Dirk H Busch; Eric G Pamer; Hiroyuki Kuwano; Yasunobu Yoshikai
Overexpression of IL-15 in vivo increases antigen-driven memory CD8+ T cells following a microbe exposure.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(3):1198-203.
2002: Shinji Murosak; Koutarou Muroyama; Yoshihiro Yamamoto; Tiei Liu; Yasunobu Yoshikai
Nigerooligosaccharides augments natural killer activity of hepatic mononuclear cells in mice.
International immunopharmacology 2002;2(1):151-9.
2001: Kazuhiro Ishiguro; Kenji Kadomatsu; Tetsuhito Kojima; Hisako Muramatsu; M Iwase; Yasunobu Yoshikai; Masamitsu Yanada; Koji Yamamoto; Tadashi Matsushita; M Nishimura; K Kusugami; Hidehiko Saito; Takashi Muramatsu
Syndecan-4 deficiency leads to high mortality of lipopolysaccharide-injected mice.
The Journal of biological chemistry 2001;276(50):47483-8.
2001: M Kato; T Matsuguchi; Yoshinari Ono; Ryohei Hattori; Shinichi Ohshima; Yasunobu Yoshikai
Characterization of CD28(-)CD4(+) T cells in living kidney transplant patients with long-term allograft acceptance.
Human immunology 2001;62(12):1335-45.
2001: Tetsuya Matsuguchi; Tipayaratn Musikacharoen; T R Johnson; Andrew Kraft; Yasunobu Yoshikai
A novel mitogen-activated protein kinase phosphatase is an important negative regulator of lipopolysaccharide-mediated c-Jun N-terminal kinase activation in mouse macrophage cell lines.
Molecular and cellular biology 2001;21(20):6999-7009.
2001: Masayuki Umemura; Hitoshi Nishimura; K Hirose; Tetsuya Matsuguchi; Yasunobu Yoshikai
Overexpression of IL-15 in vivo enhances protection against Mycobacterium bovis bacillus Calmette-Guérin infection via augmentation of NK and T cytotoxic 1 responses.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(2):946-56.
2001: Akio Masuda; Tetsuya Matsuguchi; K Yamaki; Tetsuo Hayakawa; Yasunobu Yoshikai
Interleukin-15 prevents mouse mast cell apoptosis through STAT6-mediated Bcl-xL expression.
The Journal of biological chemistry 2001;276(28):26107-13.
2001: Ryotaro Ishimitsu; Hitoshi Nishimura; Hideyuki Kawauchi; T Kawakita; Yasunobu Yoshikai
Dichotomous effect of a traditional Japanese medicine, bu-zhong-yi-qi-tang on allergic asthma in mice.
International immunopharmacology 2001;1(5):857-65.
2001: Tipayaratn Musikacharoen; Tetsuya Matsuguchi; Takeshi Kikuchi; Yasunobu Yoshikai
NF-kappa B and STAT5 play important roles in the regulation of mouse Toll-like receptor 2 gene expression.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(7):4516-24.
2001: Toshiki Yajima; Hitoshi Nishimura; Ryotaro Ishimitsu; K Yamamura; Taketo Watase; D H Busch; Eric G Pamer; Hiroyuki Kuwano; Yasunobu Yoshikai
Memory phenotype CD8(+) T cells in IL-15 transgenic mice are involved in early protection against a primary infection with Listeria monocytogenes.
European journal of immunology 2001;31(3):757-66.
2001: Takeshi Kikuchi; Tetsuya Matsuguchi; Naotake Tsuboi; Akio Mitani; S Tanaka; Masanori Matsuoka; G Yamamoto; T Hishikawa; Toshihide Noguchi; Yasunobu Yoshikai
Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via Toll-like receptors.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(5):3574-9.
2001: Ryotaro Ishimitsu; Hitoshi Nishimura; Toshiki Yajima; Taketo Watase; Hideyuki Kawauchi; Yasunobu Yoshikai
Overexpression of IL-15 in vivo enhances Tc1 response, which inhibits allergic inflammation in a murine model of asthma.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(3):1991-2001.
2001: Hitoshi Nishimura; M Tagaya; H Tsunobuchi; H Suzuki; I Nakashima; Yasunobu Yoshikai
Mice lacking interleukin-2 (IL-2)/IL-15 receptor beta chain are susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar choleraesuis but mice lacking IL-2 are resistant.
Infection and immunity 2001;69(2):1226-9.
2001: Masayuki Umemura; K Hirose; W Wajjwaiku; Hitoshi Nishimura; Tetsuya Matsuguchi; Y Gotoh; Masahide Takahashi; Masahiko Makino; Yasunobu Yoshikai
Impaired IL-15 production associated with susceptibility of murine AIDS to mycobacterial infection.
Journal of leukocyte biology 2001;69(1):138-48.
2001: T Hara; Hitoshi Nishimura; Y Hasegawa; Yasunobu Yoshikai
Thymus-dependent modulation of Ly49 inhibitory receptor expression on NK1.1+gamma/delta T cells.
Immunology 2001;102(1):24-30.
2000: K I Iwami; Tetsuya Matsuguchi; Akio Masuda; Takeshi Kikuchi; Tipayaratn Musikacharoen; Yasunobu Yoshikai
Cutting edge: naturally occurring soluble form of mouse Toll-like receptor 4 inhibits lipopolysaccharide signaling.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):6682-6.
2000: Tetsuya Matsuguchi; Tipayaratn Musikacharoen; T Ogawa; Yasunobu Yoshikai
Gene expressions of Toll-like receptor 2, but not Toll-like receptor 4, is induced by LPS and inflammatory cytokines in mouse macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(10):5767-72.
2000: H Tsunobuchi; Hitoshi Nishimura; Fumi Goshima; Tohru Daikoku; Yukihiro Nishiyama; Yasunobu Yoshikai
Memory-type CD8+ T cells protect IL-2 receptor alpha-deficient mice from systemic infection with herpes simplex virus type 2.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(8):4552-60.
2000: Akio Masuda; Tetsuya Matsuguchi; K Yamaki; Tetsuo Hayakawa; M Kubo; W J LaRochelle; Yasunobu Yoshikai
Interleukin-15 induces rapid tyrosine phosphorylation of STAT6 and the expression of interleukin-4 in mouse mast cells.
The Journal of biological chemistry 2000;275(38):29331-7.
2000: H Tsunobuchi; Hitoshi Nishimura; Fumi Goshima; Tohru Daikoku; H Suzuki; I Nakashima; Yukihiro Nishiyama; Yasunobu Yoshikai
A protective role of interleukin-15 in a mouse model for systemic infection with herpes simplex virus.
Virology 2000;275(1):57-66.
2000: Masayuki Umemura; Worawidh Wajjwalku; Narin upragarin; T Liu; Hitoshi Nishimura; Tetsuya Matsuguchi; Yukihiro Nishiyama; G M Wilson; Yasunobu Yoshikai
Expression of mouse mammary tumor virus superantigen accelerates tumorigenicity of myeloma cells.
Journal of virology 2000;74(18):8226-33.
2000: Yasuji Mokuno; Tetsuya Matsuguchi; M Takano; Hitoshi Nishimura; Junji Washizu; T Ogawa; Osamu Takeuchi; Shizuo Akira; Yuji Nimura; Yasunobu Yoshikai
Expression of toll-like receptor 2 on gamma delta T cells bearing invariant V gamma 6/V delta 1 induced by Escherichia coli infection in mice.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(2):931-40.
2000: Shinji Murosaki; Koutarou Muroyama; Yoshihiro Yamamoto; Yasunobu Yoshikai
Antitumor effect of heat-killed Lactobacillus plantarum L-137 through restoration of impaired interleukin-12 production in tumor-bearing mice.
Cancer immunology, immunotherapy : CII 2000;49(3):157-64.
2000: Y Naiki; Hitoshi Nishimura; Shigeyoshi Itohara; Yasunobu Yoshikai
gammadelta T cells may dichotomously modulate infection with avirulent Salmonella choleraesuis via IFN-gamma and IL-13 in mice.
Cellular immunology 2000;202(1):61-9.
2000: T Liu; Hitoshi Nishimura; Tetsuya Matsuguchi; Yasunobu Yoshikai
Differences in interleukin-12 and -15 production by dendritic cells at the early stage of Listeria monocytogenes infection between BALB/c and C57 BL/6 mice.
Cellular immunology 2000;202(1):31-40.
2000: K Kimura; Hitoshi Nishimura; T Matsuzaki; Teruo Yokokura; Yuji Nimura; Yasunobu Yoshikai
Synergistic effect of interleukin-15 and interleukin-12 on antitumor activity in a murine malignant pleurisy model.
Cancer immunology, immunotherapy : CII 2000;49(2):71-7.
2000: Yasunobu Yoshikai; Hitoshi Nishimura
The role of interleukin 15 in mounting an immune response against microbial infections.
Microbes and infection / Institut Pasteur 2000;2(4):381-9.
2000: Tetsuya Matsuguchi; K Takagi; Tipayaratn Musikacharoen; Yasunobu Yoshikai
Gene expressions of lipopolysaccharide receptors, toll-like receptors 2 and 4, are differently regulated in mouse T lymphocytes.
Blood 2000;95(4):1378-85.
2000: T Ninomiya; H Takimoto; Goro Matsuzaki; S Hamano; Hiroki Yoshida; Yasunobu Yoshikai; G Kimura; Kikuo Nomoto
Vgamma1+ gammadelta T cells play protective roles at an early phase of murine cytomegalovirus infection through production of interferon-gamma.
Immunology 2000;99(2):187-94.
2000: Hitoshi Nishimura; Toshiki Yajima; Y Naiki; H Tsunobuchi; Masayuki Umemura; K Itano; Tetsuya Matsuguchi; M Suzuki; P S Ohashi; Yasunobu Yoshikai
Differential roles of interleukin 15 mRNA isoforms generated by alternative splicing in immune responses in vivo.
The Journal of experimental medicine 2000;191(1):157-70.
1999: Yasuji Mokuno; M Takano; Tetsuya Matsuguchi; Hitoshi Nishimura; Junji Washizu; Y Naiki; Yuji Nimura; Yasunobu Yoshikai
Prostaglandin E(1) protects against liver injury induced by Escherichia coli infection via a dominant Th2-like response of liver T cells in mice.
Hepatology (Baltimore, Md.) 1999;30(6):1464-72.
1999: S Tanaka; Y Kimura; Akio Mitani; G Yamamoto; Hitoshi Nishimura; R Spallek; M Singh; Toshihide Noguchi; Yasunobu Yoshikai
Activation of T cells recognizing an epitope of heat-shock protein 70 can protect against rat adjuvant arthritis.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(10):5560-5.
1999: T Mayumi; J Takezawa; H Takahashi; H Yamaguchi; Hitoshi Nishimura; A Enomoto; S Ichiyama; Yasunobu Yoshikai
IL-15 is elevated in the patients of postoperative enterocolitis.
Cytokine 1999;11(11):888-93.
1999: K Hirose; Hitoshi Nishimura; Tetsuya Matsuguchi; Yasunobu Yoshikai
Endogenous IL-15 might be responsible for early protection by natural killer cells against infection with an avirulent strain of Salmonella choleraesuis in mice.
Journal of leukocyte biology 1999;66(3):382-90.
1999: Y Naiki; Hitoshi Nishimura; T Kawano; Y Tanaka; Shigeyoshi Itohara; M Taniguchi; Yasunobu Yoshikai
Regulatory role of peritoneal NK1.1+ alpha beta T cells in IL-12 production during Salmonella infection.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(4):2057-63.
1999: M Ishigami; Hitoshi Nishimura; Y Naiki; K Yoshioka; T Kawano; Y Tanaka; M Taniguchi; S Kakumu; Yasunobu Yoshikai
The roles of intrahepatic Valpha14(+) NK1.1(+) T cells for liver injury induced by Salmonella infection in mice.
Hepatology (Baltimore, Md.) 1999;29(6):1799-808.
1999: Akio Mitani; Hitoshi Nishimura; K Hirose; Junji Washizu; Y Kimura; S Tanaka; G Yamamoto; Toshihide Noguchi; Yasunobu Yoshikai
Interleukin-15 production at the early stage after oral infection with Listeria monocytogenes in mice.
Immunology 1999;97(1):92-9.
1999: K Kimura; Hitoshi Nishimura; K Hirose; Tetsuya Matsuguchi; Yuji Nimura; Yasunobu Yoshikai
Immunogene therapy of murine fibrosarcoma using IL-15 gene with high translation efficiency.
European journal of immunology 1999;29(5):1532-42.
1999: Shinji Murosaki; Koutarou Muroyama; Yoshihiro Yamamoto; H Kusaka; T Liu; Yasunobu Yoshikai
Immunopotentiating activity of nigerooligosaccharides for the T helper 1-like immune response in mice.
Bioscience, biotechnology, and biochemistry 1999;63(2):373-8.
1999: Hitoshi Nishimura; Junji Washizu; Y Naiki; T Hara; Y Fukui; T Sasazuki; Yasunobu Yoshikai
MHC class II-dependent NK1.1+ gammadelta T cells are induced in mice by Salmonella infection.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(3):1573-81.
1999: Yasunobu Yoshikai
The interaction of intestinal epithelial cells and intraepithelial lymphocytes in host defense.
Immunologic research 1999;20(3):219-35.
1999: M Ishigami; Hitoshi Nishimura; K Yoshioka; S Kakumu; Yasunobu Yoshikai
The role of intrahepatic gammadelta-T cells for liver injury induced by Salmonella infection in mouse.
Microbiology and immunology 1999;43(5):461-9.
1999: K Yamada; Y Kimura; Hitoshi Nishimura; Y Namii; M Murase; Yasunobu Yoshikai
Characterization of CD4+ CD8alphaalpha+ and CD4-CD8alphaalpha+ intestinal intraepithelial lymphocytes in rats.
International immunology 1999;11(1):21-8.
1998: K Hirose; H Suzuki; Hitoshi Nishimura; Akio Mitani; Junji Washizu; Tetsuya Matsuguchi; Yasunobu Yoshikai
Interleukin-15 may be responsible for early activation of intestinal intraepithelial lymphocytes after oral infection with Listeria monocytogenes in rats.
Infection and immunity 1998;66(12):5677-83.
1998: M Takano; Hitoshi Nishimura; Y Kimura; Junji Washizu; Yasuji Mokuno; Yuji Nimura; Yasunobu Yoshikai
Prostaglandin E2 protects against liver injury after Escherichia coli infection but hampers the resolution of the infection in mice.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(6):3019-25.
1998: Shinji Murosaki; Yoshihiro Yamamoto; K Ito; T Inokuchi; H Kusaka; H Ikeda; Yasunobu Yoshikai
Heat-killed Lactobacillus plantarum L-137 suppresses naturally fed antigen-specific IgE production by stimulation of IL-12 production in mice.
The Journal of allergy and clinical immunology 1998;102(1):57-64.
1998: M Takano; Hitoshi Nishimura; Y Kimura; Yasuji Mokuno; Junji Washizu; Shigeyoshi Itohara; Yuji Nimura; Yasunobu Yoshikai
Protective roles of gamma delta T cells and interleukin-15 in Escherichia coli infection in mice.
Infection and immunity 1998;66(7):3270-8.
1998: Yasunobu Yoshikai
[The roles of heat shock proteins in host defense against bacterial infection].
Rinsho byori. The Japanese journal of clinical pathology 1998;46(6):564-73.
1998: M Takano; T Arai; Yasuji Mokuno; Hitoshi Nishimura; Yuji Nimura; Yasunobu Yoshikai
Dibutyryl cyclic adenosine monophosphate protects mice against tumor necrosis factor-alpha-induced hepatocyte apoptosis accompanied by increased heat shock protein 70 expression.
Cell stress & chaperones 1998;3(2):109-17.
1998: T Sakai; Kazuo Kusugami; Hitoshi Nishimura; Tomoaki Ando; Tokio Yamaguchi; M Ohsuga; Kenji Ina; A Enomoto; Y Kimura; Yasunobu Yoshikai
Interleukin 15 activity in the rectal mucosa of inflammatory bowel disease.
Gastroenterology 1998;114(6):1237-43.
1998: Junji Washizu; Hitoshi Nishimura; N Nakamura; Yuji Nimura; Yasunobu Yoshikai
The NF-kappaB binding site is essential for transcriptional activation of the IL-15 gene.
Immunogenetics 1998;48(1):1-7.
1998: Y Kimura; K Yamada; T Sakai; K Mishima; Hitoshi Nishimura; Y Matsumoto; M Singh; Yasunobu Yoshikai
The regulatory role of heat shock protein 70-reactive CD4+ T cells during rat listeriosis.
International immunology 1998;10(2):117-30.
1998: Hitoshi Nishimura; Junji Washizu; N Nakamura; A Enomoto; Yasunobu Yoshikai
Translational efficiency is up-regulated by alternative exon in murine IL-15 mRNA.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(2):936-42.
1997: N Kobayashi; Kenji Hiromatsu; Goro Matsuzaki; M Harada; Yoshihiro Matsumoto; Kikuo Nomoto; Yasunobu Yoshikai
A sustained increase of cytosolic Ca2+ in gammadelta T cells triggered by co-stimulation via TCR/CD3 and LFA-1.
Cell calcium 1997;22(6):421-30.
1997: K Ito; K Inagaki-Ohara; Shinji Murosaki; Hitoshi Nishimura; T Shimokata; S Torii; T Matsuda; Yasunobu Yoshikai
Murine model of IgE production with a predominant Th2-response by feeding protein antigen without adjuvants.
European journal of immunology 1997;27(12):3427-37.
1997: K Inagaki-Ohara; Hitoshi Nishimura; Akio Mitani; Yasunobu Yoshikai
Interleukin-15 preferentially promotes the growth of intestinal intraepithelial lymphocytes bearing gamma delta T cell receptor in mice.
European journal of immunology 1997;27(11):2885-91.
1997: K Inagaki-Ohara; Hitoshi Nishimura; T Sakai; D H Lynch; Yasunobu Yoshikai
Potential for involvement of Fas antigen/Fas ligand interaction in apoptosis of epithelial cells by intraepithelial lymphocytes in murine small intestine.
Laboratory investigation; a journal of technical methods and pathology 1997;77(5):421-9.
1997: S Toki; Kenji Hiromatsu; Y Aoki; Masahiko Makino; Yasunobu Yoshikai
Protective effects of granulocyte colony-stimulating factor on endotoxin shock in mice with retrovirus-induced immunodeficiency syndrome.
Cytokine 1997;9(10):781-6.
1997: Narin upragarin; Hitoshi Nishimura; Worawidh Wajjwalku; Y Ando; S Nagafuchi; T Watanabe; Yasunobu Yoshikai
T cells bearing Vbeta8 are preferentially infected with exogenous mouse mammary tumor virus.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(5):2189-95.
1997: T Sakai; Y Kimura; K Inagaki-Ohara; Kazuo Kusugami; D H Lynch; Yasunobu Yoshikai
Fas-mediated cytotoxicity by intestinal intraepithelial lymphocytes during acute graft-versus-host disease in mice.
Gastroenterology 1997;113(1):168-74.
1997: Y Fuse; Hitoshi Nishimura; Kenji Maeda; Yasunobu Yoshikai
CD95 (Fas) may control the expansion of activated T cells after elimination of bacteria in murine listeriosis.
Infection and immunity 1997;65(5):1883-91.
1997: Hitoshi Nishimura; M Emoto; K Kimura; Yasunobu Yoshikai
Hsp70 protects macrophages infected with Salmonella choleraesuis against TNF-alpha-induced cell death.
Cell stress & chaperones 1997;2(1):50-9.
1997: Y Kobayashi; K Kawai; K Ito; H Honda; G Sobue; Yasunobu Yoshikai
Aggravation of murine experimental allergic encephalomyelitis by administration of T-cell receptor gammadelta-specific antibody.
Journal of neuroimmunology 1997;73(1-2):169-74.
1997: A Enomoto; Hitoshi Nishimura; Yasunobu Yoshikai
Predominant appearance of NK1.1+ T cells producing IL-4 may be involved in the increased susceptibility of mice with the beige mutation during Salmonella infection.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(5):2268-77.
1997: K Inagaki-Ohara; T Sakai; G Koya; A Awaya; Yasunobu Yoshikai
A thymic hormone protects mice from enteropathy during acute graft-versus-host disease.
Microbiology and immunology 1997;41(11):883-9.
1997: Y Aoki; Yasunobu Yoshikai
Further clonal expansion of T cells upon rechallenge of superantigen staphylococcal enterotoxin A.
Microbiology and immunology 1997;41(4):337-43.
1997: Kenji Hiromatsu; J Usami; Y Aoki; Masahiko Makino; Yasunobu Yoshikai
Accelerated progression of a murine retrovirus-induced immunodeficiency syndrome in Fas mutant C57BL/6 lpr/lpr mice.
Microbiology and immunology 1997;41(3):221-7.
1997: Shinji Murosaki; K Inagaki-Ohara; H Kusaka; H Ikeda; Yasunobu Yoshikai
Apoptosis of intestinal intraepithelial lymphocytes induced by exogenous and endogenous glucocorticoids.
Microbiology and immunology 1997;41(2):139-48.
1997: Yasunobu Yoshikai; Hiroyuki Kidokoro; K Kimura; Y Aoki; Masahiko Makino; Kenji Hiromatsu
Clonal expansion of superantigen-reactive T cells is resistant to FK506 in mice with AIDS.
Journal of virology 1997;71(1):746-9.
1996: Kenji Hiromatsu; Hitoshi Nishimura; K Kimura; Y Aoki; J Usami; N Kobayashi; Masahiko Makino; Yasunobu Yoshikai
Th0-like CD4+ T cells protect mice with murine retrovirus-induced immunodeficiency syndrome (MAIDS) against co-infection with Listeria monocytogenes.
Immunology 1996;89(4):532-8.
1996: J Usami; Kenji Hiromatsu; Y Aoki; N Kobayashi; Masahiko Makino; H Yagita; Yoshihiro Matsumoto; K Maeda; Yasunobu Yoshikai
Apoptosis by CD95 (Fas)-dependent and -independent mechanisms in Peyer's patch lymphocytes in murine retrovirus-induced immunodeficiency syndrome.
Journal of virology 1996;70(12):8917-25.
1996: Y Ando; W Wajjwalku; K Kishihara; T Arai; Norihiro Niimi; Kenji Hiromatsu; Tsuneo Morishima; Yasunobu Yoshikai
CD4 expression is important but not essential for infection with exogenous mouse mammary tumor virus.
Immunobiology 1996;195(3):376-84.
1996: K Kawai; Yasuna Kobayashi; M Shiratori; Gen Sobue; T Tamatani; M Miyasaka; Yasunobu Yoshikai
Intrathecal administration of antibodies against LFA-1 and against ICAM-1 suppresses experimental allergic encephalomyelitis in rats.
Cellular immunology 1996;171(2):262-8.
1996: H Inagaki; T Suzuki; K Nomoto; Yasunobu Yoshikai
Increased susceptibility to primary infection with Listeria monocytogenes in germfree mice may be due to lack of accumulation of L-selectin+ CD44+ T cells in sites of inflammation.
Infection and immunity 1996;64(8):3280-7.
1996: K Inagaki-Ohara; N Kobayashi; Hitoshi Nishimura; T Sakai; Y Matsumoto; K Hiromatsu; A Awaya; Yasunobu Yoshikai
Effects of a nonapeptide thymic hormone on intestinal intraepithelial lymphocytes in mice following administration of 5-fluorouracil.
Cellular immunology 1996;171(1):30-40.
1996: T Iwata; Y Kamei; S Esaki; T Takada; S Torii; A Yamashita; Shuta Tomida; T Tamatani; M Miyasaka; Yasunobu Yoshikai
Immunosuppression by anti-ICAM-1 and anti-LFA-1 monoclonal antibodies of free and vascularized skin allograft rejection.
Immunobiology 1996;195(2):160-71.
1996: Hitoshi Nishimura; Kenji Hiromatsu; N Kobayashi; K H Grabstein; R Paxton; K Sugamura; J A Bluestone; Yasunobu Yoshikai
IL-15 is a novel growth factor for murine gamma delta T cells induced by Salmonella infection.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(2):663-9.
1996: Y Kimura; T Sakai; M Takeuchi; Y Matsumoto; K Watanabe; M Yuuki; T Takada; Yasunobu Yoshikai
An unique CD4+CD8+ intestinal intraepithelial lymphocyte specific for DnaK (Escherichia coli HSP70) may be selected by intestinal microflora of rats.
Immunobiology 1996;196(5):550-66.
1996: H Morita; Ken-Ichi Isobe; Z Cai; T Miyazaki; Y Matsumoto; Takahiro Shinzato; Yasunobu Yoshikai; K Kimata; K Maeda
Thy-1 antigen mediates apoptosis of rat glomerular cells in vitro and in vivo.
Nephron 1996;73(2):293-8.
1996: N Nakamura; W Wajjwalku; Hitoshi Nishimura; H Okubo; Norihiro Niimi; Y Ando; Yasunobu Yoshikai
Nucleotide sequences of env and 3'LTROrf genes of endogenous mouse mammary tumor viruses encoding superantigen specific for TcrVbeta2.
Immunogenetics 1996;44(4):319-20.
1996: Y Kimura; Shuta Tomida; Yoshihiro Matsumoto; Kenji Hiromatsu; Yasunobu Yoshikai
Evidence for the early recruitment of T-cell receptor gamma delta+ T cells during rat listeriosis.
Immunology 1996;87(1):21-8.
1995: T Arai; Kenji Hiromatsu; N Kobayashi; M Takano; H Ishida; Yuji Nimura; Yasunobu Yoshikai
IL-10 is involved in the protective effect of dibutyryl cyclic adenosine monophosphate on endotoxin-induced inflammatory liver injury.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(12):5743-9.
1995: Norihiro Niimi; W Wajjwalku; Y Ando; N Nakamura; Minoru Ueda; Yasunobu Yoshikai
A novel V beta 2-specific endogenous mouse mammary tumor virus which is capable of producing a milk-borne exogenous virus.
Journal of virology 1995;69(11):7269-73.
1995: Yoshihiro Matsumoto; Takahiro Shinzato; Izumi Amano; Ichiro Takai; Y Kimura; H Morita; Masamiki Miwa; K Nakane; Yasunobu Yoshikai; K Maeda
Relationship between susceptibility to apoptosis and Fas expression in peripheral blood T cells from uremic patients: a possible mechanism for lymphopenia in chronic renal failure.
Biochemical and biophysical research communications 1995;215(1):98-105.
1995: Y Aoki; Kenji Hiromatsu; T Arai; J Usami; Masahiko Makino; H Ishida; Yasunobu Yoshikai
Lethal shock is inducible by lipopolysaccharide but not by superantigen in mice with retrovirus-induced immunodeficiency syndrome.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(7):3494-500.
1995: J Usami; Kenji Hiromatsu; Yoshihiro Matsumoto; K Maeda; H Inagaki; T Suzuki; Yasunobu Yoshikai
A protective role of gamma delta T cells in primary infection with Listeria monocytogenes in autoimmune non-obese diabetic mice.
Immunology 1995;86(2):199-205.
1995: M Emoto; Hitoshi Nishimura; T Sakai; Kenji Hiromatsu; H Gomi; Shigeyoshi Itohara; Yasunobu Yoshikai
Mice deficient in gamma delta T cells are resistant to lethal infection with Salmonella choleraesuis.
Infection and immunity 1995;63(9):3736-8.
1995: Yasuna Kobayashi; K Kawai; Hiroyuki Honda; Shuta Tomida; Norihiro Niimi; T Tamatani; M Miyasaka; Yasunobu Yoshikai
Antibodies against leukocyte function-associated antigen-1 and against intercellular adhesion molecule-1 together suppress the progression of experimental allergic encephalomyelitis.
Cellular immunology 1995;164(2):295-305.
1995: T Arai; Kenji Hiromatsu; Hitoshi Nishimura; Y Kimura; N Kobayashi; H Ishida; Yuji Nimura; Yasunobu Yoshikai
Endogenous interleukin 10 prevents apoptosis in macrophages during Salmonella infection.
Biochemical and biophysical research communications 1995;213(2):600-7.
1995: Y Aoki; Kenji Hiromatsu; N Kobayashi; Tomomitsu Hotta; H Saito; H Igarashi; Y Niho; Yasunobu Yoshikai
Protective effect of granulocyte colony-stimulating factor against T-cell-meditated lethal shock triggered by superantigens.
Blood 1995;86(4):1420-7.
1995: T Arai; Kenji Hiromatsu; Hitoshi Nishimura; Y Kimura; N Kobayashi; H Ishida; Yuji Nimura; Yasunobu Yoshikai
Effects of in vivo administration of anti-IL-10 monoclonal antibody on the host defence mechanism against murine Salmonella infection.
Immunology 1995;85(3):381-8.
1995: Y Ando; W Wajjwalku; Norihiro Niimi; Kenji Hiromatsu; Tsuneo Morishima; Yasunobu Yoshikai
Concomitant infection with exogenous mouse mammary tumor virus encoding I-E-dependent superantigen in I-E-negative mouse strain.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(12):6219-26.
1995: Takaaki Hasegawa; M Okuda; Masahiko Makino; Kenji Hiromatsu; K Nomoto; Yasunobu Yoshikai
Hot water extracts of Chlorella vulgaris reduce opportunistic infection with Listeria monocytogenes in C57BL/6 mice infected with LP-BM5 murine leukemia viruses.
International journal of immunopharmacology 1995;17(6):505-12.
1995: T Suzuki; Kenji Hiromatsu; Y Ando; T Okamoto; Y Tomoda; Yasunobu Yoshikai
Regulatory role of gamma delta T cells in uterine intraepithelial lymphocytes in maternal antifetal immune response.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(9):4476-84.
1995: Hitoshi Nishimura; M Emoto; Kenji Hiromatsu; S Yamamoto; K Matsuura; H Gomi; T Ikeda; Shigeyoshi Itohara; Yasunobu Yoshikai
The role of gamma delta T cells in priming macrophages to produce tumor necrosis factor-alpha.
European journal of immunology 1995;25(5):1465-8.
1995: N Atsuta; Hitoshi Nishimura; N Nakamura; M Emoto; T Iwatsuki; Yasunobu Yoshikai
Diversity of V gamma gene segments rearranged to the J gamma 4 gene in mice.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(2):676-84.
1995: T Sakai; K Ohara-Inagaki; T Tsuzuki; Yasunobu Yoshikai
Host intestinal intraepithelial gamma delta T lymphocytes present during acute graft-versus-host disease in mice may contribute to the development of enteropathy.
European journal of immunology 1995;25(1):87-91.
1995: W Wajjwalku; Y Ando; Norihiro Niimi; Yasunobu Yoshikai
A novel exogenous mammary tumor virus encoding MHC class II H2E-independent superantigen specific for Tcr-V beta 14.
Immunogenetics 1995;41(2-3):156-8.
1994: Kenji Hiromatsu; Yasuna Kobayashi; Yasunobu Yoshikai
[The involvement of gamma delta T cells in neurological disorders].
Nihon rinsho. Japanese journal of clinical medicine 1994;52(11):2824-9.
1994: Y Aoki; Kenji Hiromatsu; J Usami; Masahiko Makino; H Igarashi; J Ogasawara; S Nagata; Yasunobu Yoshikai
Clonal expansion but lack of subsequent clonal deletion of bacterial superantigen-reactive T cells in murine retroviral infection.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(8):3611-21.
1994: Yoshihiro Matsumoto; Kenji Hiromatsu; T Sakai; Yasuna Kobayashi; Y Kimura; J Usami; Takahiro Shinzato; K Maeda; Yasunobu Yoshikai
Co-stimulation with LFA-1 triggers apoptosis in gamma delta T cells on T cell receptor engagement.
European journal of immunology 1994;24(10):2441-5.
1994: Kenji Hiromatsu; Y Aoki; Masahiko Makino; Yoshihiro Matsumoto; T Mizuochi; Y Gotoh; K Nomoto; J Ogasawara; S Nagata; Yasunobu Yoshikai
Increased Fas antigen expression in murine retrovirus-induced immunodeficiency syndrome, MAIDS.
European journal of immunology 1994;24(10):2446-51.
1994: Shuta Tomida; Takaaki Hasegawa; M Takeuchi; Norihiro Niimi; Minoru Ueda; T Kaneda; Toshiyuki Tanaka; T Tamatani; M Miyasaka; Yasunobu Yoshikai
Intercellular adhesion molecule-1 and leukocyte function-associated antigen-1 are involved in protection mediated by CD3+TCR alpha beta- T cells at the early stage after infection with Listeria monocytogenes in rats.
International immunology 1994;6(7):955-61.
1994: T Ogasawara; M Emoto; K Kiyotani; Kaoru Shimokata; T Yoshida; Y Nagai; Yasunobu Yoshikai
Sendai virus pneumonia: evidence for the early recruitment of gamma delta T cells during the disease course.
Journal of virology 1994;68(6):4022-7.
1994: A Matsuura; M Katsuno; Y Suzuki; T Ito; K Yasuura; T Abe; Yasunobu Yoshikai
Cyclophosphamide-induced tolerance in fully allogeneic heart transplantation in mice.
Cellular immunology 1994;155(2):501-7.
1994: Takaaki Hasegawa; M Okuda; K Nomoto; Yasunobu Yoshikai
Augmentation of the resistance against Listeria monocytogenes by oral administration of a hot water extract of Chlorella vulgaris in mice.
Immunopharmacology and immunotoxicology 1994;16(2):191-202.
1994: T Tsuzuki; Yasunobu Yoshikai; M Ito; N Mori; M Ohbayashi; J Asai
Kinetics of intestinal intraepithelial lymphocytes during acute graft-versus-host disease in mice.
European journal of immunology 1994;24(3):709-15.
1994: Norihiro Niimi; W Wajjwalku; Y Ando; Shuta Tomida; M Takeuchi; Minoru Ueda; T Kaneda; Yasunobu Yoshikai
Delay in expression of a mammary tumor provirus is responsible for defective clonal deletion during postnatal period.
European journal of immunology 1994;24(2):488-91.
1994: H Miyazaki; M Tanaka; Y Takeda; S Takeo; K Nomoto; Yasunobu Yoshikai
Effect of antitumor polysaccharide SPR-901 on antitumor activity in combination with 5-FU.
International journal of immunopharmacology 1994;16(2):163-70.
1994: Norihiro Niimi; W Wajjwalku; Y Ando; Shuta Tomida; Minoru Ueda; Yasunobu Yoshikai
A new gene encoding the ligand for deletion of T cells bearing Tcrb-V6 and V8.1 (Mtv-50).
Immunogenetics 1994;40(4):312.
1994: Yoshihiro Matsumoto; M Emoto; J Usami; K Maeda; Yasunobu Yoshikai
A protective role of extrathymic alpha beta TcR cells in the liver in primary murine salmonellosis.
Immunology 1994;81(1):8-14.
1993: Yasunobu Yoshikai
[Viral superantigens].
Uirusu 1993;43(1):119-27.
1993: M Takeuchi; H Miyazaki; K Mirokawa; T Yokokura; Yasunobu Yoshikai
Age-related changes of T cell subsets in intestinal intraepithelial lymphocytes of mice.
European journal of immunology 1993;23(6):1409-11.
1993: M Emoto; T Naito; R Nakamura; Yasunobu Yoshikai
Different appearance of gamma delta T cells during salmonellosis between Ityr and Itys mice.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(8 Pt 1):3411-20.
1993: W Wajjwalku; Shuta Tomida; M Takahashi; M Matsuyama; Yasunobu Yoshikai
A gene encoding the ligand for deletion of T cells bearing TcrV beta 6 and V beta 8.1 cosegregates with a new endogenous mouse mammary tumor virus.
Immunogenetics 1993;37(5):397-400.
1992: M Takeuchi; A Iwasaki; K Nomoto; Yasunobu Yoshikai
Rat thymic epithelium positively selects mouse T cells with specificity for rat MHC class II antigens but fails to induce detectable tolerance in the mouse T cells to the rat MHC antigens.
Immunobiology 1992;186(5):421-34.
1992: Takaaki Hasegawa; Toshiyuki Tanaka; Yasunobu Yoshikai
The appearance and role of gamma delta T cells in the peritoneal cavity and liver during primary infection with Listeria monocytogenes in rats.
International immunology 1992;4(10):1129-36.
1992: M Emoto; H Danbara; Yasunobu Yoshikai
Induction of gamma/delta T cells in murine salmonellosis by an avirulent but not by a virulent strain of Salmonella choleraesuis.
The Journal of experimental medicine 1992;176(2):363-72.
1992: Yasunobu Yoshikai
Regulatory role of heat shock protein-specific T cells in host defense.
Nagoya journal of medical science 1992;54(1-4):11-26.
1992: H Takimoto; T Nakamura; M Takeuchi; Y Sumi; Toshiyuki Tanaka; K Nomoto; Yasunobu Yoshikai
Age-associated increase in number of CD4+CD8+ intestinal intraepithelial lymphocytes in rats.
European journal of immunology 1992;22(1):159-64.
1991: Yasunobu Yoshikai; A Ishida; Shinji Murosaki; T Ando; K Nomoto
Sequential appearance of T-cell receptor gamma delta- and alpha beta-bearing intestinal intra-epithelial lymphocytes in mice after irradiation.
Immunology 1991;74(4):583-8.
1991: Yasunobu Yoshikai
[Participation of gamma/delta-T cells in the protection against mycobacterial infection].
Kekkaku : [Tuberculosis] 1991;66(9):621-7.
1991: Yasunobu Yoshikai
Gamma/delta T cell receptor.
Microbiology and immunology 1991;35(7):493-506.