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Yasunao Yoshimasa

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Yu Kataoka; Kazuo Kimura; Masami Kosuge; Yoshihiro Miyamoto; Shunichi Miyazaki; Kazuhiro Sase; Satoshi Yasuda; Yasunao Yoshimasa
Effects of voglibose and nateglinide on glycemic status and coronary atherosclerosis in early-stage diabetic patients.
Yoshihiro Kokubo; Tomonori Okamura; Makoto Watanabe; Aya Higashiyama; Yuu Ono; Yoshihiro Miyamoto; Yoko Furukawa; Kei Kamide; Katsuyuki Kawanishi; Akira Okayama; Yasunao Yoshimasa
The combined impact of blood pressure category and glucose abnormality on the incidence of cardiovascular diseases in a Japanese urban cohort: the Suita Study.
Sadanori Okada; Aki Hiuge; Hisashi Makino; Ayako Nagumo; Hiroshi Takaki; Harumi Konishi; Yoichi Goto; Yasunao Yoshimasa; Yoshihiro Miyamoto
Effect of exercise intervention on endothelial function and incidence of cardiovascular disease in patients with type 2 diabetes.

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2012: Yu Kataoka; Kazuo Kimura; Masami Kosuge; Yoshihiro Miyamoto; Shunichi Miyazaki; Kazuhiro Sase; Satoshi Yasuda; Yasunao Yoshimasa
Effects of voglibose and nateglinide on glycemic status and coronary atherosclerosis in early-stage diabetic patients.
Circulation journal : official journal of the Japanese Circulation Society 2012;76(3):712-20.
2010: Yoshihiro Kokubo; Tomonori Okamura; Makoto Watanabe; Aya Higashiyama; Yuu Ono; Yoshihiro Miyamoto; Yoko Furukawa; Kei Kamide; Katsuyuki Kawanishi; Akira Okayama; Yasunao Yoshimasa
The combined impact of blood pressure category and glucose abnormality on the incidence of cardiovascular diseases in a Japanese urban cohort: the Suita Study.
Hypertension research : official journal of the Japanese Society of Hypertension 2010;33(12):1238-43.
2010: Sadanori Okada; Aki Hiuge; Hisashi Makino; Ayako Nagumo; Hiroshi Takaki; Harumi Konishi; Yoichi Goto; Yasunao Yoshimasa; Yoshihiro Miyamoto
Effect of exercise intervention on endothelial function and incidence of cardiovascular disease in patients with type 2 diabetes.
Journal of atherosclerosis and thrombosis 2010;17(8):828-33.
2010: Takako Sugisawa; Ichiro Kishimoto; Yoshihiro Kokubo; Ayako Nagumo; Hisashi Makino; Yoshihiro Miyamoto; Yasunao Yoshimasa
Visceral fat is negatively associated with B-type natriuretic peptide levels in patients with advanced type 2 diabetes.
Diabetes research and clinical practice 2010;89(2):174-80.
2010: Mariko Harada-Shiba; Takako Sugisawa; Hisashi Makino; Mitsuru Abe; Motoo Tsushima; Yasunao Yoshimasa; Takahiro Yamashita; Yoshihiro Miyamoto; Akira Yamamoto; Hitonobu Tomoike; Shinji Yokoyama
Impact of statin treatment on the clinical fate of heterozygous familial hypercholesterolemia.
Journal of atherosclerosis and thrombosis 2010;17(7):667-74.
2010: Tomonori Okamura; Yoshihiro Kokubo; Makoto Watanabe; Aya Higashiyama; Yuu Ono; Yoshihiro Miyamoto; Yasunao Yoshimasa; Akira Okayama
Triglycerides and non-high-density lipoprotein cholesterol and the incidence of cardiovascular disease in an urban Japanese cohort: the Suita study.
Atherosclerosis 2010;209(1):290-4.
2010: Koji Harada; Yoshihiro Miyamoto; Hiroko Morisaki; Naotaka Ohta; Itaru Yamanaka; Yoshihiro Kokubo; Hisashi Makino; Mariko Harada-Shiba; Akira Okayama; Hitonobu Tomoike; Tomonori Okamura; Okamura Tomonori; Yoshihiko Saito; Yasunao Yoshimasa; Takayuki Morisaki
A novel Thr56Met mutation of the autosomal recessive hypercholesterolemia gene associated with hypercholesterolemia.
Journal of atherosclerosis and thrombosis 2010;17(2):131-40.
2010: Takako Sugisawa; Ichiro Kishimoto; Yoshihiro Kokubo; Hisashi Makino; Yoshihiro Miyamoto; Yasunao Yoshimasa
Association of plasma B-type natriuretic peptide levels with obesity in a general urban Japanese population: the Suita Study.
Endocrine journal 2010;57(8):727-33.
2009: Yoshihiro Miyamoto; Hiroko Morisaki; Itaru Yamanaka; Yoshihiro Kokubo; Hiroaki Masuzaki; Akira Okayama; Hitonobu Tomoike; Kazuwa Nakao; Tomonori Okamura; Yasunao Yoshimasa; Takayuki Morisaki
Association study of 11beta-hydroxysteroid dehydrogenase type 1 gene polymorphisms and metabolic syndrome in urban Japanese cohort.
Diabetes research and clinical practice 2009;85(2):132-8.
2009: Yoshihiro Kokubo; Satoko Nakamura; Tomonori Okamura; Yasunao Yoshimasa; Hisashi Makino; Makoto Watanabe; Aya Higashiyama; Kei Kamide; Katsuyuki Kawanishi; Akira Okayama; Yuhei Kawano
Relationship between blood pressure category and incidence of stroke and myocardial infarction in an urban Japanese population with and without chronic kidney disease: the Suita Study.
Stroke; a journal of cerebral circulation 2009;40(8):2674-9.
2009: Tomonori Okamura; Yoshihiro Kokubo; Makoto Watanabe; Aya Higashiyama; Yoshihiro Miyamoto; Yasunao Yoshimasa; Akira Okayama
Low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol and the incidence of cardiovascular disease in an urban Japanese cohort study: The Suita study.
Atherosclerosis 2009;203(2):587-92.
2009: Makoto Kawamura; Hiroaki Itoh; Shigeo Yura; Haruta Mogami; Tsuyoshi Fujii; Hisashi Makino; Yoshihiro Miyamoto; Yasunao Yoshimasa; Seiichiro Aoe; Yoshihiro Ogawa; Norimasa Sagawa; Norio Kanayama; Ikuo Konishi
Isocaloric high-protein diet ameliorates systolic blood pressure increase and cardiac remodeling caused by maternal caloric restriction in adult mouse offspring.
Endocrine journal 2009;56(5):679-89.
2008: Hisashi Makino; Sadanori Okada; Ayako Nagumo; Takako Sugisawa; Yoshihiro Miyamoto; Ichiro Kishimoto; Taura K Akie; Toshihiro Soma; Akihiko Taguchi; Yasunao Yoshimasa
Pioglitazone treatment stimulates circulating CD34-positive cells in type 2 diabetes patients.
Diabetes research and clinical practice 2008;81(3):327-30.
2008: Einosuke Mizuta; Yoshihiro Kokubo; Itaru Yamanaka; Yoshihiro Miyamoto; Akira Okayama; Yasunao Yoshimasa; Hitonobu Tomoike; Hiroko Morisaki; Takayuki Morisaki
Leptin gene and leptin receptor gene polymorphisms are associated with sweet preference and obesity.
Hypertension research : official journal of the Japanese Society of Hypertension 2008;31(6):1069-77.
2008: Sadanori Okada; Hisashi Makino; Ayako Nagumo; Takako Sugisawa; Muneya Fujimoto; Ichiro Kishimoto; Yoshihiro Miyamoto; Akie Kikuchi-Taura; Toshihiro Soma; Akihiko Taguchi; Yasunao Yoshimasa
Circulating CD34-positive cell number is associated with brain natriuretic peptide level in type 2 diabetic patients.
Diabetes care 2008;31(1):157-8.
2008: Hisashi Makino; Kentaro Doi; Aki Hiuge; Ayako Nagumo; Sadanori Okada; Yoshihiro Miyamoto; Masaaki Suzuki; Yasunao Yoshimasa
Impaired flow-mediated vasodilatation and insulin resistance in type 2 diabetic patients with albuminuria.
Diabetes research and clinical practice 2008;79(1):177-82.
2007: Ayaka Ito; Takayoshi Suganami; Yoshihiro Miyamoto; Yasunao Yoshimasa; Motohiro Takeya; Yasutomi Kamei; Yoshihiro Ogawa
Role of MAPK phosphatase-1 in the induction of monocyte chemoattractant protein-1 during the course of adipocyte hypertrophy.
The Journal of biological chemistry 2007;282(35):25445-52.
2007: Masaaki Suzuki; Itaru Takamisawa; Yasunao Yoshimasa; Yutaka Harano
Association between insulin resistance and endothelial dysfunction in type 2 diabetes and the effects of pioglitazone.
Diabetes research and clinical practice 2007;76(1):12-7.
2007: Makoto Kawamura; Hiroaki Itoh; Shigeo Yura; Haruta Mogami; Shin-Ichi Suga; Hisashi Makino; Yoshihiro Miyamoto; Yasunao Yoshimasa; Norimasa Sagawa; Shingo Fujii
Undernutrition in utero augments systolic blood pressure and cardiac remodeling in adult mouse offspring: possible involvement of local cardiac angiotensin system in developmental origins of cardiovascular disease.
Endocrinology 2007;148(3):1218-25.
2006: Yoshihiro Miyamoto; Yasunao Yoshimasa; Takayuki Morisaki; Hiroaki Masuzaki
[Metabolic syndrome and11beta-hydroxysteroid dehydrogenase type 1 gene polymorphisms].
Nihon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 9():334-8.
2006: Hisashi Makino; Yoshihiro Miyamoto; Kazutomo Sawai; Kiyoshi Mori; Masashi Mukoyama; Kazuwa Nakao; Yasunao Yoshimasa; Shin-ichi Suga
Altered gene expression related to glomerulogenesis and podocyte structure in early diabetic nephropathy of db/db mice and its restoration by pioglitazone.
Diabetes 2006;55(10):2747-56.
2006: Hirofumi Makino; Masashi Mukoyama; Kazuhiro J Mori; Takayoshi Suganami; Masato Kasahara; Kensei Yahata; Tetsuya Nagae; Hideki Yokoi; Kazutomo Sawai; Yoshihiro Ogawa; Shinichi Suga; Yasunao Yoshimasa; Akira Sugawara; Issei Tanaka; Kazuwa Nakao
Transgenic overexpression of brain natriuretic peptide prevents the progression of diabetic nephropathy in mice.
Diabetologia 2006;49(10):2514-24.
2006: Minoru Takaoka; Shiro Uemura; Hiroyuki Kawata; Keiichi Imagawa; Yukiji Takeda; Kimihiko Nakatani; Noriyuki Naya; Manabu Horii; Shigeru Yamano; Yoshihiro Miyamoto; Yasunao Yoshimasa; Yoshihiko Saito
Inflammatory response to acute myocardial infarction augments neointimal hyperplasia after vascular injury in a remote artery.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(9):2083-9.
2006: Masako Nakano; Taku Hamada; Tatsuya Hayashi; Shin Yonemitsu; Licht Miyamoto; Taro Toyoda; Satsuki Tanaka; Hiroaki Masuzaki; Ken Ebihara; Yoshihiro Ogawa; Kiminori Hosoda; Gen Inoue; Yasunao Yoshimasa; Akira Otaka; Tohru Fushiki; Kazuwa Nakao
α2 isoform-specific activation of 5'adenosine monophosphate-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-β-D-ribonucleoside at a physiological level activates glucose transport and increases glucose transporter 4 in mouse skeletal muscle.
Metabolism: clinical and experimental 2006;55(3):300-8.
2005: Yoshihiro Miyamoto; Yasunao Yoshimasa; Kazuwa Nakao
[Genetic testing and gene-based testing of life-style related disease].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 12():275-9.
2005: Takeshi Horio; Masaaki Suzuki; Itaru Takamisawa; Kazutaka Suzuki; Aki Hiuge; Yasunao Yoshimasa; Yuhei Kawano
Pioglitazone-induced insulin sensitization improves vascular endothelial function in nondiabetic patients with essential hypertension.
American journal of hypertension 2005;18(12 Pt 1):1626-30.
2005: Ryuji Kouyama; Takayoshi Suganami; Junko Nishida; Miyako Tanaka; Takuya Toyoda; Minako Kiso; Tsuyoshi Chiwata; Yoshihiro Miyamoto; Yasunao Yoshimasa; Akiyoshi Fukamizu; Masatsugu Horiuchi; Yukio Hirata; Yoshihiro Ogawa
Attenuation of diet-induced weight gain and adiposity through increased energy expenditure in mice lacking angiotensin II type 1a receptor.
Endocrinology 2005;146(8):3481-9.
2005: Takeshi Horio; Masaaki Suzuki; Kazutaka Suzuki; Itaru Takamisawa; Aki Hiuge; Kei Kamide; Shin Takiuchi; Yoshio Iwashima; Shinji Kihara; Tohru Funahashi; Yasunao Yoshimasa; Yuhei Kawano
Pioglitazone improves left ventricular diastolic function in patients with essential hypertension.
American journal of hypertension 2005;18(7):949-57.
2005: Koji Abe; Masafumi Nakayama; Michihiro Yoshimura; Shota Nakamura; Teruhiko Ito; Megumi Yamamuro; Tomohiro Sakamoto; Yoshihiro Miyamoto; Yasunao Yoshimasa; Yoshihiko Saito; Kazuwa Nakao; Hirofumi Yasue; Hisao Ogawa
Increase in the transcriptional activity of the endothelial nitric oxide synthase gene with fluvastatin: a relation with the -786T>C polymorphism.
Pharmacogenetics and genomics 2005;15(5):329-36.
2005: Kayoko Okazawa; Yasunao Yoshimasa; Yoshihiro Miyamoto; Akiko Takahashi-Yasuno; Takashi Miyawaki; Hiroaki Masuzaki; Tatsuya Hayashi; Kiminori Hosoda; Gen Inoue; Kazuwa Nakao
The haplotypes of the IRS-2 gene affect insulin sensitivity in Japanese patients with type 2 diabetes.
Diabetes research and clinical practice 2005;68(1):39-48.
2004: Wataru Shimizu; Takashi Noda; Hiroshi Takaki; Noritoshi Nagaya; Kazuhiro Satomi; Takashi Kurita; Kazuhiro Suyama; Naohiko Aihara; Kenji Sunagawa; Shigeyuki Echigo; Yoshihiro Miyamoto; Yasunao Yoshimasa; Kazufumi Nakamura; Tohru Ohe; Jeffrey A Towbin; silvia priori; Shiro Kamakura
Diagnostic value of epinephrine test for genotyping LQT1, LQT2, and LQT3 forms of congenital long QT syndrome.
Heart rhythm : the official journal of the Heart Rhythm Society 2004;1(3):276-83.
2004: Wataru Shimizu; Minoru Horie; Seiko Ohno; Kotoe Takenaka; Masato Yamaguchi; Masami Shimizu; Takashi Washizuka; Yoshifusa Aizawa; Kazufumi Nakamura; Tohru Ohe; Takeshi Aiba; Yoshihiro Miyamoto; Yasunao Yoshimasa; Jeffrey A Towbin; silvia priori; Shiro Kamakura
Mutation site-specific differences in arrhythmic risk and sensitivity to sympathetic stimulation in the LQT1 form of congenital long QT syndrome: multicenter study in Japan.
Journal of the American College of Cardiology 2004;44(1):117-25.
2004: Akiko Takahashi-Yasuno; Hiroaki Masuzaki; Takashi Miyawaki; Naoki Matsuoka; Yoshihiro Ogawa; Tatsuya Hayashi; Kiminori Hosoda; Yasunao Yoshimasa; Gen Inoue; Kazuwa Nakao
Association of Ob-R gene polymorphism and insulin resistance in Japanese men.
Metabolism: clinical and experimental 2004;53(5):650-4.
2004: Masaaki Suzuki; Itaru Takamisawa; Kazutaka Suzuki; Aki Hiuge; Takeshi Horio; Yasunao Yoshimasa; Yutaka Harano
Close association of endothelial dysfunction with insulin resistance and carotid wall thickening in hypertension.
American journal of hypertension 2004;17(3):228-32.
2003: Koichiro Kuwahara; Yoshihiko Saito; Makoto Takano; Yuji Arai; Shinji Yasuno; Yasuaki Nakagawa; Nobuki Takahashi; Yuichiro Adachi; Genzo Takemura; Minoru Horie; Yoshihiro Miyamoto; Takayuki Morisaki; Shinobu Kuratomi; Akinori Noma; Hisayoshi Fujiwara; Yasunao Yoshimasa; Hideyuki Kinoshita; Rika Kawakami; Ichiro Kishimoto; Michio Nakanishi; Satoru Usami; Yoshihiko Saito; Masaki Harada; Kazuwa Nakao
NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function.
The EMBO journal 2003;22(23):6310-21.
2003: Akiko Takahashi-Yasuno; Hiroaki Masuzaki; Takashi Miyawaki; Yoshihiro Ogawa; Naoki Matsuoka; Tatsuya Hayashi; Kiminori Hosoda; Gen Inoue; Yasunao Yoshimasa; Kazuwa Nakao
Leptin receptor polymorphism is associated with serum lipid levels and impairment of cholesterol lowering effect by simvastatin in Japanese men.
Diabetes research and clinical practice 2003;62(3):169-75.
2002: T Miyawaki; Hiroaki Masuzaki; Yoshihiro Ogawa; Kiminori Hosoda; H Nishimura; N Azuma; A Sugawara; Izuru Masuda; M Murata; T Matsuo; T Hayashi; G Inoue; Yasunao Yoshimasa; Kazuwa Nakao
Clinical implications of leptin and its potential humoral regulators in long-term low-calorie diet therapy for obese humans.
European journal of clinical nutrition 2002;56(7):593-600.
2002: Tomohiko Okuda; Yoshihiko Fujioka; Kei Kamide; Yuhei Kawano; Yoichi Goto; Yasunao Yoshimasa; Hitonobu Tomoike; Naoharu Iwai; Sotaro Hanai; Toshiyuki Miyata
Verification of 525 coding SNPs in 179 hypertension candidate genes in the Japanese population: identification of 159 SNPs in 93 genes.
Journal of human genetics 2002;47(8):387-94.
2001: Yasunao Yoshimasa
[A role of the PPAR gamma activation in insulin resistance].
Nihon rinsho. Japanese journal of clinical medicine 2001;59(11):2173-8.
2001: Choel Son; Kiminori Hosoda; J Matsuda; Junji Fujikura; Shin Yonemitsu; Hiroshi Iwakura; Hiroaki Masuzaki; Yoshihiro Ogawa; Takeshi Hayashi; Hiroaki Itoh; Haruo Nishimura; Gen Inoue; Yasunao Yoshimasa; Y Yamori; Kazuwa Nakao
Up-regulation of uncoupling protein 3 gene expression by fatty acids and agonists for PPARs in L6 myotubes.
Endocrinology 2001;142(10):4189-94.
2001: Gen Inoue; T Sakurai; Kiyoji Tanaka; Takashi Akamizu; H Masuzaki; K Hosoda; Takeshi Hayashi; Yasunao Yoshimasa; Kazuwa Nakao
Simultaneous onset of type 1 diabetes mellitus and painless thyroiditis following acute pancreatitis.
Internal medicine (Tokyo, Japan) 2001;40(6):515-8.
2001: Ken Ebihara; Yoshihiro Ogawa; Hiroaki Masuzaki; Mitsuyo Shintani; Fumiko Miyanaga; Megumi Aizawa-Abe; Takeshi Hayashi; Kiminori Hosoda; Gen Inoue; Yasunao Yoshimasa; Oksana Gavrilova; Marc L Reitman; Kazuwa Nakao
Transgenic overexpression of leptin rescues insulin resistance and diabetes in a mouse model of lipoatrophic diabetes.
Diabetes 2001;50(6):1440-8.
2000: M Kotani; Issei Tanaka; Yoshihiro Ogawa; Takayoshi Suganami; Toshio Matsumoto; Shigeo Muro; Y Yamamoto; Akira Sugawara; Yasunao Yoshimasa; Norimasa Sagawa; Shuh Narumiya; Kazuwa Nakao
Multiple signal transduction pathways through two prostaglandin E receptor EP3 subtype isoforms expressed in human uterus.
The Journal of clinical endocrinology and metabolism 2000;85(11):4315-22.
2000: Megumi Aizawa-Abe; Yoshihiro Ogawa; Hiroaki Masuzaki; Ken Ebihara; Noriko Satoh; H Iwai; Naoki Matsuoka; Takeshi Hayashi; Kiminori Hosoda; Gen Inoue; Yasunao Yoshimasa; Kazuwa Nakao
Pathophysiological role of leptin in obesity-related hypertension.
The Journal of clinical investigation 2000;105(9):1243-52.
2000: Yoshihiko Yamamoto; Yasunao Yoshimasa; M Koh; J Suga; Hiroaki Masuzaki; Yoshihiro Ogawa; Kiminori Hosoda; Haruo Nishimura; Y Watanabe; Gen Inoue; Kazuwa Nakao
Constitutively active mitogen-activated protein kinase kinase increases GLUT1 expression and recruits both GLUT1 and GLUT4 at the cell surface in 3T3-L1 adipocytes.
Diabetes 2000;49(3):332-9.
2000: Mitsuyo Shintani; Haruo Nishimura; Shin Yonemitsu; Hiroaki Masuzaki; Yoshihiro Ogawa; Kiminori Hosoda; Gen Inoue; Yasunao Yoshimasa; Kazuwa Nakao
Downregulation of leptin by free fatty acids in rat adipocytes: effects of triacsin C, palmitate, and 2-bromopalmitate.
Metabolism: clinical and experimental 2000;49(3):326-30.
1999: Mitsuyo Shintani; Haruo Nishimura; Takashi Akamizu; Shin Yonemitsu; Hiroaki Masuzaki; Yoshihiro Ogawa; Kiminori Hosoda; Gen Inoue; Yasunao Yoshimasa; Kazuwa Nakao
Thyrotropin decreases leptin production in rat adipocytes.
Metabolism: clinical and experimental 1999;48(12):1570-4.
1999: Ken Ebihara; Yoshihiro Ogawa; Goro Katsuura; Yoshito Numata; Hiroaki Masuzaki; Noriko Satoh; M Tamaki; T Yoshioka; M Hayase; Naoki Matsuoka; Megumi Aizawa-Abe; Yasunao Yoshimasa; Kazuwa Nakao
Involvement of agouti-related protein, an endogenous antagonist of hypothalamic melanocortin receptor, in leptin action.
Diabetes 1999;48(10):2028-33.
1999: Yoshihiro Ogawa; Hiroaki Masuzaki; Kiminori Hosoda; Megumi Aizawa-Abe; J Suga; M Suda; Ken Ebihara; H Iwai; Naoki Matsuoka; Noriko Satoh; H Odaka; H Kasuga; Y Fujisawa; Gen Inoue; Haruo Nishimura; Yasunao Yoshimasa; Kazuwa Nakao
Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin.
Diabetes 1999;48(9):1822-9.
1999: Noriko Satoh; Yoshihiro Ogawa; Goro Katsuura; Yoshito Numata; Teruyuki Tsuji; M Hayase; Ken Ebihara; Hiroaki Masuzaki; Kiminori Hosoda; Yasunao Yoshimasa; Kazuwa Nakao
Sympathetic activation of leptin via the ventromedial hypothalamus: leptin-induced increase in catecholamine secretion.
Diabetes 1999;48(9):1787-93.
1999: Hiroaki Masuzaki; Yoshihiro Ogawa; Megumi Aizawa-Abe; Kiminori Hosoda; J Suga; Ken Ebihara; Noriko Satoh; H Iwai; Gen Inoue; Haruo Nishimura; Yasunao Yoshimasa; Kazuwa Nakao
Glucose metabolism and insulin sensitivity in transgenic mice overexpressing leptin with lethal yellow agouti mutation: usefulness of leptin for the treatment of obesity-associated diabetes.
Diabetes 1999;48(8):1615-22.
1999: Hiroaki Itoh; Kentaro Doi; Toshihiko Tanaka; Yasutomo Fukunaga; Kiminori Hosoda; Gen Inoue; Haruo Nishimura; Yasunao Yoshimasa; Yukio Yamori; Kazuwa Nakao
Hypertension and insulin resistance: role of peroxisome proliferator-activated receptor gamma.
Clinical and experimental pharmacology & physiology 1999;26(7):558-60.
1999: Tomohiro Tanaka; H Itoh; K Doi; Yasutomo Fukunaga; Kiminori Hosoda; Mitsuyo Shintani; J Yamashita; Tae-Hwa Chun; Mayumi Inoue; Ken Masatsugu; N Sawada; T Saito; Gen Inoue; Haruo Nishimura; Yasunao Yoshimasa; Kazuwa Nakao
Down regulation of peroxisome proliferator-activated receptorgamma expression by inflammatory cytokines and its reversal by thiazolidinediones.
Diabetologia 1999;42(6):702-10.
1998: J Matsuda; Kiminori Hosoda; Hiroaki Itoh; C Son; Kentaro Doi; I Hanaoka; Gen Inoue; Haruo Nishimura; Yasunao Yoshimasa; Yukio Yamori; H Odaka; Kazuwa Nakao
Increased adipose expression of the uncoupling protein-3 gene by thiazolidinediones in Wistar fatty rats and in cultured adipocytes.
Diabetes 1998;47(11):1809-14.
1998: Yoshihiro Miyamoto; Yoshihiko Saito; Noboru Kajiyama; M Yoshimura; Yukio Shimasaki; M Nakayama; Shigeki Kamitani; Masaki Harada; M Ishikawa; Koichiro Kuwahara; Emiko Ogawa; Ichiro Hamanaka; Nobuki Takahashi; T Kaneshige; H Teraoka; Takashi Akamizu; N Azuma; Yasunao Yoshimasa; T Yoshimasa; Hiroaki Itoh; Izuru Masuda; H Yasue; Kazuwa Nakao
Endothelial nitric oxide synthase gene is positively associated with essential hypertension.
Hypertension 1998;32(1):3-8.
1998: Noriko Satoh; Yoshihiro Ogawa; Goro Katsuura; Yoshito Numata; Hiroaki Masuzaki; Yasunao Yoshimasa; Kazuwa Nakao
Satiety effect and sympathetic activation of leptin are mediated by hypothalamic melanocortin system.
Neuroscience letters 1998;249(2-3):107-10.
1998: N Azuma; Yasunao Yoshimasa; Haruo Nishimura; Yoshihiko Yamamoto; Hiroaki Masuzaki; J Suga; M Shigemoto; Naoki Matsuoka; Toshihiko Tanaka; Noriko Satoh; T Igaki; Yoshihiro Miyamoto; Hiroaki Itoh; T Yoshimasa; Kiminori Hosoda; S Nishi; Kazuwa Nakao
The significance of the Trp 64 Arg mutation of the beta3-adrenergic receptor gene in impaired glucose tolerance, non-insulin-dependent diabetes mellitus, and insulin resistance in Japanese subjects.
Metabolism: clinical and experimental 1998;47(4):456-60.
1998: M Shigemoto; Yasunao Yoshimasa; Yoshihiko Yamamoto; Takeshi Hayashi; J Suga; Gen Inoue; M Okamoto; Hisato Jingami; K Tsuda; T Yamamoto; Toru Yagura; M Oishi; Satoru Tsujii; Hideshi Kuzuya; Kazuwa Nakao
Clinical manifestations due to a point mutation of the mitochondrial tRNAleu(UUR) gene in five families with diabetes mellitus.
Internal medicine (Tokyo, Japan) 1998;37(3):265-72.
1997: J Matsuda; Kiminori Hosoda; Hiroaki Itoh; C Son; Kentaro Doi; Toshihiko Tanaka; Yasutomo Fukunaga; Gen Inoue; Haruo Nishimura; Yasunao Yoshimasa; Yukio Yamori; Kazuwa Nakao
Cloning of rat uncoupling protein-3 and uncoupling protein-2 cDNAs: their gene expression in rats fed high-fat diet.
FEBS letters 1997;418(1-2):200-4.
1997: M Shigemoto; S Nishi; Y Ogawa; N Isse; Naoki Matsuoka; Toshihiko Tanaka; N Azuma; Hiroaki Masuzaki; Haruo Nishimura; Yasunao Yoshimasa; Kiminori Hosoda; Kazuwa Nakao
Molecular screening of both the promoter and the protein coding regions in the human ob gene in Japanese obese subjects with non-insulin-dependent diabetes mellitus.
European journal of endocrinology / European Federation of Endocrine Societies 1997;137(5):511-3.
1997: Y Fukunaga; N Azuma; Hiroyuki Koshiyama; D Inoue; H Sato; Yasunao Yoshimasa; K Nakao
Mitochondrial DNA 3243 mutation is infrequent in Japanese diabetic patients with auditory disturbance.
Diabetes care 1997;20(11):1800-3.
1997: N Matsuoka; Yoshihiro Ogawa; Kiminori Hosoda; J Matsuda; Hiroaki Masuzaki; T Miyawaki; N Azuma; Koshi Natsui; Haruo Nishimura; Yasunao Yoshimasa; S Nishi; D B Thompson; Kazuwa Nakao
Human leptin receptor gene in obese Japanese subjects: evidence against either obesity-causing mutations or association of sequence variants with obesity.
Diabetologia 1997;40(10):1204-10.
1997: Hiroaki Masuzaki; Yoshihiro Ogawa; Norimasa Sagawa; Kiminori Hosoda; Toshio Matsumoto; Hiroko Mise; H Nishimura; Yasunao Yoshimasa; I Tanaka; Takahide Mori; Kazuwa Nakao
Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans.
Nature medicine 1997;3(9):1029-33.
1997: Hiroaki Masuzaki; Yoshihiro Ogawa; Kiminori Hosoda; T Miyawaki; I Hanaoka; J Hiraoka; A Yasuno; Haruo Nishimura; Yasunao Yoshimasa; S Nishi; Kazuwa Nakao
Glucocorticoid regulation of leptin synthesis and secretion in humans: elevated plasma leptin levels in Cushing's syndrome.
The Journal of clinical endocrinology and metabolism 1997;82(8):2542-7.
1997: J Suga; Yasunao Yoshimasa; Kenneth M Yamada; Yoshihiko Yamamoto; Gen Inoue; M Okamoto; Takeshi Hayashi; M Shigemoto; A Kosaki; Hideshi Kuzuya; Kazuwa Nakao
Differential activation of mitogen-activated protein kinase by insulin and epidermal growth factor in 3T3-L1 adipocytes: a possible involvement of PI3-kinase in the activation of the MAP kinase by insulin.
Diabetes 1997;46(5):735-41.
1997: Noriko Satoh; Yoshihiro Ogawa; Goro Katsuura; M Hayase; Teruyuki Tsuji; Keiichi Imagawa; Yasunao Yoshimasa; S Nishi; Kiminori Hosoda; Kazuwa Nakao
The arcuate nucleus as a primary site of satiety effect of leptin in rats.
Neuroscience letters 1997;224(3):149-52.
1997: Noriko Satoh; Yoshihiro Ogawa; Goro Katsuura; Teruyuki Tsuji; Hiroaki Masuzaki; J Hiraoka; T Okazaki; M Tamaki; M Hayase; Yasunao Yoshimasa; S Nishi; Kiminori Hosoda; Kazuwa Nakao
Pathophysiological significance of the obese gene product, leptin, in ventromedial hypothalamus (VMH)-lesioned rats: evidence for loss of its satiety effect in VMH-lesioned rats.
Endocrinology 1997;138(3):947-54.
1997: T Yamamoto; Yasunao Yoshimasa; Hiroyuki Koshiyama; K Sugiyama; M Okigaki; T Yamada; H Ishii; Toru Yagura; K Fujimoto; T Ohnishi; T Koh; M Hino; H Kurahachi; T Yoshimasa; Kazuwa Nakao
Lack of mutations of preproparathyroid hormone gene in three kindreds with familial isolated hypoparathyroidism.
Endocrine journal 1997;44(1):175-80.
1997: N Murakami; Gen Inoue; M Okamoto; Yasunao Yoshimasa; S Kohno; T Hayashi; K Kato; Hideshi Kuzuya; K Nakao
Antihyperglycemic mechanism of M16209, an antidiabetic agent, in 3T3-L1 adipocytes.
Life sciences 1997;60(20):1821-31.
1996: Takeshi Hayashi; M Okamoto; Yasunao Yoshimasa; Gen Inoue; Kenneth M Yamada; S Kono; M Shigemoto; J Suga; Hideshi Kuzuya; Kazuwa Nakao
Insulin-induced activation of phosphoinositide 3-kinase in Fao cells.
Diabetologia 1996;39(5):515-22.
1996: Kiminori Hosoda; Hiroaki Masuzaki; Yoshihiro Ogawa; T Miyawaki; J Hiraoka; I Hanaoka; A Yasuno; T Nomura; Y Fujisawa; Yasunao Yoshimasa; S Nishi; Yukio Yamori; Kazuwa Nakao
Development of radioimmunoassay for human leptin.
Biochemical and biophysical research communications 1996;221(2):234-9.
1996: Hiroaki Masuzaki; Kiminori Hosoda; Yoshihiro Ogawa; M Shigemoto; N Satoh; Kazuhiro J Mori; Naohisa Tamura; S Nishi; Yasunao Yoshimasa; Yukio Yamori; Kazuwa Nakao
Augmented expression of obese (ob) gene during the process of obesity in genetically obese-hyperglycemic Wistar fatty (fa/fa) rats.
FEBS letters 1996;378(3):267-71.
1996: Hiroaki Masuzaki; H Jingami; Naoki Matsuoka; O Nakagawa; Yoshihiro Ogawa; M Mizuno; Yasunao Yoshimasa; T Yamamoto; Kazuwa Nakao
Regulation of very-low-density lipoprotein receptor in hypertrophic rat heart.
Circulation research 1996;78(1):8-14.
1995: H Tsukaguchi; Yasunao Yoshimasa; K Fujimoto; H Ishii; T Yamamoto; T Yoshimasa; T Yagura; J Takamatsu
Three novel mutations of thyroid hormone receptor beta gene in unrelated patients with resistance to thyroid hormone: two mutations of the same codon (H435L and H435Q) produce separate subtypes of resistance.
The Journal of clinical endocrinology and metabolism 1995;80(12):3613-6.
1995: N Isse; Yoshihiro Ogawa; Naohisa Tamura; Hiroaki Masuzaki; Kazuhiro J Mori; Toshiro Okazaki; N Satoh; M Shigemoto; Yasunao Yoshimasa; S Nishi
Structural organization and chromosomal assignment of the human obese gene.
The Journal of biological chemistry 1995;270(46):27728-33.
1995: Yoshihiro Ogawa; Hiroaki Masuzaki; N Isse; Toshiro Okazaki; Kazuhiro J Mori; M Shigemoto; N Satoh; Naohisa Tamura; Kiminori Hosoda; Yasunao Yoshimasa
Molecular cloning of rat obese cDNA and augmented gene expression in genetically obese Zucker fatty (fa/fa) rats.
The Journal of clinical investigation 1995;96(3):1647-52.
1995: Hiroaki Masuzaki; Yoshihiro Ogawa; N Isse; N Satoh; Toshiro Okazaki; M Shigemoto; Kazuhiro J Mori; Naohisa Tamura; Kiminori Hosoda; Yasunao Yoshimasa
Human obese gene expression. Adipocyte-specific expression and regional differences in the adipose tissue.
Diabetes 1995;44(7):855-8.
1995: H Tsukaguchi; Hiroaki Matsubara; Yasukiyo Mori; Yasunao Yoshimasa; T Yoshimasa; K Nakao; M Inada
Two vasopressin type 2 receptor gene mutations R143P and delta V278 in patients with nephrogenic diabetes insipidus impair ligand binding of the receptor.
Biochemical and biophysical research communications 1995;211(3):967-77.
1994: M Pashmforoush; Yasunao Yoshimasa; Donald F Steiner
Exon 11 enhances insulin binding affinity and tyrosine kinase activity of the human insulin proreceptor.
The Journal of biological chemistry 1994;269(51):32639-48.
1994: Takeshi Kurose; M Pashmforoush; Yasunao Yoshimasa; Raymond Carroll; G P Schwartz; G T Burke; P G Katsoyannis; Donald F Steiner
Cross-linking of a B25 azidophenylalanine insulin derivative to the carboxyl-terminal region of the alpha-subunit of the insulin receptor. Identification of a new insulin-binding domain in the insulin receptor.
The Journal of biological chemistry 1994;269(46):29190-7.
1994: S Kono; Hideshi Kuzuya; Kenneth M Yamada; Yasunao Yoshimasa; M Okamoto; Gen Inoue; Takeshi Hayashi; J Suga; Hiroshi Imura; Kazuwa Nakao
A novel substrate for insulin-sensitive serine/threonine kinase in intact cells.
Endocrinology 1994;135(4):1529-36.
1993: S Kono; Hideshi Kuzuya; Kenneth M Yamada; Yasunao Yoshimasa; M Okamoto; Gen Inoue; Takeshi Hayashi; Kazuwa Nakao; Hiroshi Imura
Anti-phosphoserine and anti-phosphothreonine antibodies modulate autophosphorylation of the insulin receptor but not EGF receptor.
Biochemical and biophysical research communications 1993;196(1):216-22.
1993: Gen Inoue; Hideshi Kuzuya; Takeshi Hayashi; M Okamoto; Yasunao Yoshimasa; A Kosaki; S Kono; M Okamoto; I Maeda; Masaru Kubota
Effects of ML-9 on insulin stimulation of glucose transport in 3T3-L1 adipocytes.
The Journal of biological chemistry 1993;268(7):5272-8.
1993: S Kono; Hideshi Kuzuya; Kenneth M Yamada; Yasunao Yoshimasa; M Okamoto; Haruo Nishimura; A Kosaki; Gen Inoue; Takeshi Hayashi; Hiroshi Imura
Preparation of anti-phosphoserine and anti-phosphothreonine antibodies and their application in the study of insulin- and EGF-induced phosphorylation.
Biochemical and biophysical research communications 1993;190(1):283-8.
1992: M Okamoto; M Okamoto; Kenneth M Yamada; Yasunao Yoshimasa; A Kosaki; S Kono; Gen Inoue; I Maeda; Masaru Kubota; Takeshi Hayashi
Insulin resistance in Werner's syndrome.
Mechanisms of ageing and development 1992;63(1):11-25.
1990: Yasunao Yoshimasa; J I Paul; J Whittaker; Donald F Steiner
Effects of amino acid replacements within the tetrabasic cleavage site on the processing of the human insulin receptor precursor expressed in Chinese hamster ovary cells.
The Journal of biological chemistry 1990;265(28):17230-7.
1990: T Kakehi; Hideshi Kuzuya; A Kosaki; Kenneth M Yamada; Yasunao Yoshimasa; M Okamoto; Haruo Nishimura; H Nishitani; K Saida; S Kuno
Binding activity and autophosphorylation of the insulin receptor from patients with myotonic dystrophy.
The Journal of laboratory and clinical medicine 1990;115(6):688-95.
1989: Hideshi Kuzuya; Yasunao Yoshimasa; T Kakehi; A Kosaki; Hiroshi Imura
[Insulin resistance due to genetic defects of insulin receptors].
Nihon rinsho. Japanese journal of clinical medicine 1989;47(10):2403-8.
1988: H Tsukahara; K Kikuchi; Hideshi Kuzuya; E Ito; Y Oda; A Kosaki; T Kakehi; Haruo Nishimura; Kenneth M Yamada; Yasunao Yoshimasa
Insulin resistance in a boy with congenital generalized lipodystrophy.
Pediatric research 1988;24(6):668-72.
1988: A Kosaki; Hideshi Kuzuya; Yasunao Yoshimasa; Kenneth M Yamada; M Okamoto; Haruo Nishimura; T Kakehi; J Takeda; Yutaka Seino; Hiroshi Imura
Regulation of glucose-transporter gene expression by insulin in cultured human fibroblasts.
Diabetes 1988;37(11):1583-6.
1988: T Kakehi; A Hisatomi; Hideshi Kuzuya; Yasunao Yoshimasa; M Okamoto; Kenneth M Yamada; Haruo Nishimura; A Kosaki; H Nawata; F Umeda
Defective processing of insulin-receptor precursor in cultured lymphocytes from a patient with extreme insulin resistance.
The Journal of clinical investigation 1988;81(6):2020-2.
1988: Yasunao Yoshimasa; S Seino; J Whittaker; T Kakehi; A Kosaki; Hideshi Kuzuya; Hiroshi Imura; Graeme I Bell; Donald F Steiner
Insulin-resistant diabetes due to a point mutation that prevents insulin proreceptor processing.
Science (New York, N.Y.) 1988;240(4853):784-7.
1988: T Kakehi; Hideshi Kuzuya; Yasunao Yoshimasa; Kenneth M Yamada; M Okamoto; Haruo Nishimura; Hiroshi Imura
Binding and tyrosine kinase activities of the insulin receptor on Epstein-Barr virus transformed lymphocytes from patients with Werner's syndrome.
Journal of gerontology 1988;43(2):M40-5.
1988: Haruo Nishimura; Hideshi Kuzuya; M Okamoto; Yasunao Yoshimasa; Kenneth M Yamada; T Ida; T Kakehi; Hiroshi Imura
Change of insulin action with aging in conscious rats determined by euglycemic clamp.
The American journal of physiology 1988;254(1 Pt 1):E92-8.