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Akihiko Yoshimura
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34
Kobayashi, Takashi
21
Hanada, Toshikatsu
21
Takaesu, Giichi
19
Sasaki, Atsuo
18
Yasukawa, Hideo
15
Saeki, Kazuko
15
Kinjyo, Ichiko
13
Aki, Daisuke
13
Yoshida, Hiroki
12
Kubo, Masato
11
Kato, Reiko
11
Matsuda, Tadashi
11
Minoda, Yasumasa
10
Fukuyama, Satoru
10
Yoshida, Ryoko
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All Publications
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2009: Taniguchi Koji; Ishizaki Takuma; Ayada Toranoshin; Sugiyama Yuki; Wakabayashi Yu; Sekiya Takashi; Nakagawa Ryusuke; Yoshimura Akihiko
Sprouty4 deficiency potentiates Ras-independent angiogenic signals and tumor growth.
Cancer science 2009;100(9):1648-54.
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2009: Sekine Yuichi; Yamamoto Chikako; Ikeda Osamu; Muromoto Ryuta; Nanbo Asuka; Oritani Kenji; Yoshimura Akihiko; Matsuda Tadashi
The protein content of an adaptor protein, STAP-2 is controlled by E3 ubiquitin ligase Cbl.
Biochemical and biophysical research communications 2009;384(2):187-92.
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2009: Ikeda Osamu; Miyasaka Yuto; Sekine Yuichi; Mizushima Akihiro; Muromoto Ryuta; Nanbo Asuka; Yoshimura Akihiko; Matsuda Tadashi
STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation.
Biochemical and biophysical research communications 2009;384(1):71-5.
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2009: Fukuyama Satoru; Nakano Takako; Matsumoto Takafumi; Oliver Brian G G; Burgess Janette K; Moriwaki Atsushi; Tanaka Kentaro; Kubo Masato; Hoshino Tomoaki; Tanaka Hiroyuki; McKenzie Andrew N J; Matsumoto Koichiro; Aizawa Hisamichi; Nakanishi Yoichi; Yoshimura Akihiko; Black Judith L; Inoue Hiromasa
Pulmonary suppressor of cytokine signaling-1 induced by IL-13 regulates allergic asthma phenotype.
American journal of respiratory and critical care medicine 2009;179(11):992-8.
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2009: Saeki Kazuko; Fukuyama Satoru; Ayada Toranoshin; Nakaya Mako; Aki Daisuke; Takaesu Giichi; Hanada Toshikatsu; Matsumura Yumiko; Kobayashi Takashi; Nakagawa Ryusuke; Yoshimura Akihiko
A major lipid raft protein raftlin modulates T cell receptor signaling and enhances th17-mediated autoimmune responses.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(10):5929-37.
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2009: Hashimoto Masayuki; Ayada Toranoshin; Kinjyo Ichiko; Hiwatashi Kiyokazu; Yoshida Hideyuki; Okada Yasunori; Kobayashi Takashi; Yoshimura Akihiko
Silencing of SOCS1 in macrophages suppresses tumor development by enhancing antitumor inflammation.
Cancer science 2009;100(4):730-6.
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2009: Minoda Yasumasa; Sakurai Hiroaki; Kobayashi Takashi; Yoshimura Akihiko; Takaesu Giichi
An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1beta signaling pathway.
Biochemical and biophysical research communications 2009;381(3):412-7.
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2009: Yoshimura Takeru; Sonoda Koh-Hei; Ohguro Nobuyuki; Ohsugi Yoshiyuki; Ishibashi Tatsuro; Cua Daniel J; Kobayashi Takashi; Yoshida Hiroki; Yoshimura Akihiko
Involvement of Th17 cells and the effect of anti-IL-6 therapy in autoimmune uveitis.
Rheumatology (Oxford, England) 2009;48(4):347-54.
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2009: Koga Keiko; Takaesu Giichi; Yoshida Ryoko; Nakaya Mako; Kobayashi Takashi; Kinjyo Ichiko; Yoshimura Akihiko
Cyclic adenosine monophosphate suppresses the transcription of proinflammatory cytokines via the phosphorylated c-Fos protein.
Immunity 2009;30(3):372-83.
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2009: Taniguchi Koji; Sasaki Ken-ichiro; Watari Kousuke; Yasukawa Hideo; Imaizumi Tsutomu; Ayada Toranoshin; Okamoto Fuyuki; Ishizaki Takuma; Kato Reiko; Kohno Ri-ichiro; Kimura Hiroshi; Sato Yasufumi; Ono Mayumi; Yonemitsu Yoshikazu; Yoshimura Akihiko
Suppression of Sproutys has a therapeutic effect for a mouse model of ischemia by enhancing angiogenesis.
PloS one 2009;4(5):e5467.
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2009: Kobayashi Takashi; Kim Tae Soo; Jacob Anand; Walsh Matthew C; Kadono Yuho; Fuentes-Pananá Ezequiel; Yoshioka Tomoko; Yoshimura Akihiko; Yamamoto Masahiro; Kaisho Tsuneyasu; Akira Shizuo; Monroe John G; Choi Yongwon
TRAF6 is required for generation of the B-1a B cell compartment as well as T cell-dependent and -independent humoral immune responses.
PloS one 2009;4(3):e4736.
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2008: Sanada Takahito; Takaesu Giichi; Mashima Ryuichi; Yoshida Ryoko; Kobayashi Takashi; Yoshimura Akihiko
FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway.
The Journal of biological chemistry 2008;283(49):33858-64.
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2008: Sugiyama N; Nakashima H; Yoshimura T; Sadanaga A; Shimizu S; Masutani K; Igawa T; Akahoshi M; Miyake K; Takeda A; Yoshimura A; Hamano S; Yoshida H
Amelioration of human lupus-like phenotypes in MRL/lpr mice by overexpression of interleukin 27 receptor alpha (WSX-1).
Annals of the rheumatic diseases 2008;67(10):1461-7.
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2008: Ikeda Osamu; Sekine Yuichi; Muromoto Ryuta; Ohbayashi Norihiko; Yoshimura Akihiko; Matsuda Tadashi
Enhanced c-Fms/M-CSF receptor signaling and wound-healing process in bone marrow-derived macrophages of signal-transducing adaptor protein-2 (STAP-2) deficient mice.
Biological & pharmaceutical bulletin 2008;31(9):1790-3.
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2008: Shiraishi Hiroshi; Yoshida Hideyuki; Saeki Kazuko; Miura Yoshiki; Watanabe Satoko; Ishizaki Takuma; Hashimoto Masayuki; Takaesu Giichi; Kobayashi Takashi; Yoshimura Akihiko
Prostaglandin E2 is a major soluble factor produced by stromal cells for preventing inflammatory cytokine production from dendritic cells.
International immunology 2008;20(9):1219-29.
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2008: Ikeda Osamu; Sekine Yuichi; Yasui Teruhito; Oritani Kenji; Sugiyma Kenji; Muromoto Ryuta; Ohbayashi Norihiko; Yoshimura Akihiko; Matsuda Tadashi
STAP-2 negatively regulates both canonical and noncanonical NF-kappaB activation induced by Epstein-Barr virus-derived latent membrane protein 1.
Molecular and cellular biology 2008;28(16):5027-42.
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2008: Haffner Michael C; Jurgeit Andreas; Berlato Chiara; Geley Stephan; Parajuli Nirmala; Yoshimura Akihiko; Doppler Wolfgang
Interaction and functional interference of glucocorticoid receptor and SOCS1.
The Journal of biological chemistry 2008;283(32):22089-96.
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2008: Ichiyama Kenji; Yoshida Hideyuki; Wakabayashi Yu; Chinen Takatoshi; Saeki Kazuko; Nakaya Mako; Takaesu Giichi; Hori Shohei; Yoshimura Akihiko; Kobayashi Takashi
Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat.
The Journal of biological chemistry 2008;283(25):17003-8.
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2008: Takaki Hiromi; Ichiyama Kenji; Koga Keiko; Chinen Takatoshi; Takaesu Giichi; Sugiyama Yuki; Kato Shigeaki; Yoshimura Akihiko; Kobayashi Takashi
STAT6 Inhibits TGF-beta1-mediated Foxp3 induction through direct binding to the Foxp3 promoter, which is reverted by retinoic acid receptor.
The Journal of biological chemistry 2008;283(22):14955-62.
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2008: Torisu Takehiro; Nakaya Mako; Watanabe Satoko; Hashimoto Masayuki; Yoshida Hideyuki; Chinen Takatoshi; Yoshida Ryoko; Okamoto Fuyuki; Hanada Toshikatsu; Torisu Kumiko; Takaesu Giichi; Kobayashi Takashi; Yasukawa Hideo; Yoshimura Akihiko
Suppressor of cytokine signaling 1 protects mice against concanavalin A-induced hepatitis by inhibiting apoptosis.
Hepatology (Baltimore, Md.) 2008;47(5):1644-54.
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2008: Tanaka Kentaro; Ichiyama Kenji; Hashimoto Masayuki; Yoshida Hideyuki; Takimoto Tomohito; Takaesu Giichi; Torisu Takehiro; Hanada Toshikatsu; Yasukawa Hideo; Fukuyama Satoru; Inoue Hiromasa; Nakanishi Yoichi; Kobayashi Takashi; Yoshimura Akihiko
Loss of suppressor of cytokine signaling 1 in helper T cells leads to defective Th17 differentiation by enhancing antagonistic effects of IFN-gamma on STAT3 and Smads.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(6):3746-56.
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2008: Aki Daisuke; Minoda Yasumasa; Yoshida Hideyuki; Watanabe Satoko; Yoshida Ryoko; Takaesu Giichi; Chinen Takatoshi; Inaba Toshiya; Hikida Masaki; Kurosaki Tomohiro; Saeki Kazuko; Yoshimura Akihiko
Peptidoglycan and lipopolysaccharide activate PLCgamma2, leading to enhanced cytokine production in macrophages and dendritic cells.
Genes to cells : devoted to molecular & cellular mechanisms 2008;13(2):199-208.
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2008: Yoshimura Takeru; Sonoda Koh-Hei; Miyazaki Yoshiyuki; Iwakura Yoichiro; Ishibashi Tatsuro; Yoshimura Akihiko; Yoshida Hiroki
Differential roles for IFN-gamma and IL-17 in experimental autoimmune uveoretinitis.
International immunology 2008;20(2):209-14.
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2008: Yu Qingsheng; Minoda Yasumasa; Yoshida Ryoko; Yoshida Hideyuki; Iha Hidekatsu; Kobayashi Takashi; Yoshimura Akihiko; Takaesu Giichi
HTLV-1 Tax-mediated TAK1 activation involves TAB2 adapter protein.
Biochemical and biophysical research communications 2008;365(1):189-94.
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2007: Yamauchi Moriyasu; Hashimoto Masayuki; Ichiyama Kenji; Yoshida Ryoko; Hanada Toshikatsu; Muta Tatsushi; Komune Shizuo; Kobayashi Takashi; Yoshimura Akihiko
Ifi202, an IFN-inducible candidate gene for lupus susceptibility in NZB/W F1 mice, is a positive regulator for NF-kappaB activation in dendritic cells.
International immunology 2007;19(8):935-42.
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2007: Sekine Yuichi; Tsuji Satoshi; Ikeda Osamu; Sugiyma Kenji; Oritani Kenji; Shimoda Kazuya; Muromoto Ryuta; Ohbayashi Norihiko; Yoshimura Akihiko; Matsuda Tadashi
Signal-transducing adaptor protein-2 regulates integrin-mediated T cell adhesion through protein degradation of focal adhesion kinase.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(4):2397-407.
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2007: Matsumura Yumiko; Kobayashi Takashi; Ichiyama Kenji; Yoshida Ryoko; Hashimoto Masayuki; Takimoto Tomohito; Tanaka Kentaro; Chinen Takatoshi; Shichita Takashi; Wyss-Coray Tony; Sato Katsuaki; Yoshimura Akihiko
Selective expansion of foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokine signaling 3-deficient dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(4):2170-9.
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2007: Mori Hiroyuki; Shichita Takashi; Yu Qingsheng; Yoshida Ryoko; Hashimoto Masayuki; Okamoto Fuyuki; Torisu Takahiro; Nakaya Mako; Kobayashi Takashi; Takaesu Giichi; Yoshimura Akihiko
Suppression of SOCS3 expression in the pancreatic beta-cell leads to resistance to type 1 diabetes.
Biochemical and biophysical research communications 2007;359(4):952-8.
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2007: Ikeda Osamu; Sekine Yuichi; Kakisaka Michinori; Tsuji Satoshi; Muromoto Ryuta; Ohbayashi Norihiko; Oritani Kenji; Yoshimura Akihiko; Matsuda Tadashi
STAP-2 regulates c-Fms/M-CSF receptor signaling in murine macrophage Raw 264.7 cells.
Biochemical and biophysical research communications 2007;358(3):931-7.
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2007: Yoshimura Akihiko; Tanaka Kentaro; Okamoto Fuyuki; Kobayashi Takashi
[Intracellular negative signals and allergy]
Arerugi = [Allergy] 2007;56(6):563-9.
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2007: Yoshimura Akihiko; Naka Tetsuji; Kubo Masato
SOCS proteins, cytokine signalling and immune regulation.
Nature reviews. Immunology 2007;7(6):454-65.
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2007: Taniguchi Koji; Kohno Ri-Ichiro; Ayada Toranoshin; Kato Reiko; Ichiyama Kenji; Morisada Tohru; Oike Yuichi; Yonemitsu Yoshikazu; Maehara Yoshihiko; Yoshimura Akihiko
Spreds are essential for embryonic lymphangiogenesis by regulating vascular endothelial growth factor receptor 3 signaling.
Molecular and cellular biology 2007;27(12):4541-50.
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2007: Nishinakamura Hitomi; Minoda Yasumasa; Saeki Kazuko; Koga Keiko; Takaesu Giichi; Onodera Masafumi; Yoshimura Akihiko; Kobayashi Takashi
An RNA-binding protein alphaCP-1 is involved in the STAT3-mediated suppression of NF-kappaB transcriptional activity.
International immunology 2007;19(5):609-19.
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2007: Sekine Yuichi; Tsuji Satoshi; Ikeda Osamu; Kakisaka Michinori; Sugiyama Kenji; Yoshimura Akihiko; Matsuda Tadashi
Leukemia inhibitory factor-induced phosphorylation of STAP-2 on tyrosine-250 is involved in its STAT3-enhancing activity.
Biochemical and biophysical research communications 2007;356(2):517-22.
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2007: Yoshiga Daigo; Sato Naoichi; Torisu Takehiro; Mori Hiroyuki; Yoshida Ryoko; Nakamura Seiji; Takaesu Giichi; Kobayashi Takashi; Yoshimura Akihiko
Adaptor protein SH2-B linking receptor-tyrosine kinase and Akt promotes adipocyte differentiation by regulating peroxisome proliferator-activated receptor gamma messenger ribonucleic acid levels.
Molecular endocrinology (Baltimore, Md.) 2007;21(5):1120-31.
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2007: Shudo Emi; Yang Jin; Yoshimura Akihiko; Iwasa Yoh
Robustness of the signal transduction system of the mammalian JAK/STAT pathway and dimerization steps.
Journal of theoretical biology 2007;246(1):1-9.
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2007: Torisu Takehiro; Sato Naoichi; Yoshiga Daigo; Kobayashi Takashi; Yoshioka Tomoko; Mori Hiroyuki; Iida Mitsuo; Yoshimura Akihiko
The dual function of hepatic SOCS3 in insulin resistance in vivo.
Genes to cells : devoted to molecular & cellular mechanisms 2007;12(2):143-54.
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2007: Taniguchi Koji; Ayada Toranoshin; Ichiyama Kenji; Kohno Ri-Ichiro; Yonemitsu Yoshikazu; Minami Yasuhiro; Kikuchi Akira; Maehara Yoshihiko; Yoshimura Akihiko
Sprouty2 and Sprouty4 are essential for embryonic morphogenesis and regulation of FGF signaling.
Biochemical and biophysical research communications 2007;352(4):896-902.
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2007: Kinjyo Ichiko; Ohishi Masanobu; Shouda Takanori; Kobayashi Takashi; Yoshimura Akihiko
Positive and negative roles of IL-6, STAT3, and SOCS3 in inflammatory arthritis.
Advances in experimental medicine and biology 2007;602():113-24.
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2007: Inoue Hiromasa; Fukuyama Satoru; Matsumoto Koichiro; Kubo Masato; Yoshimura Akihiko
Role of endogenous inhibitors of cytokine signaling in allergic asthma.
Current medicinal chemistry 2007;14(2):181-9.
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2006: Lu Yang; Fukuyama Satoru; Yoshida Ryoko; Kobayashi Takashi; Saeki Kazuko; Shiraishi Hiroshi; Yoshimura Akihiko; Takaesu Giichi
Loss of SOCS3 gene expression converts STAT3 function from anti-apoptotic to pro-apoptotic.
The Journal of biological chemistry 2006;281(48):36683-90.
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2006: Yoshimura Takeru; Takeda Atsunobu; Hamano Shinjiro; Miyazaki Yoshiyuki; Kinjyo Ichiko; Ishibashi Tatsuro; Yoshimura Akihiko; Yoshida Hiroki
Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):5377-85.
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2006: Shiraishi Hiroshi; Okamoto Hideaki; Yoshimura Akihiko; Yoshida Hiroki
ER stress-induced apoptosis and caspase-12 activation occurs downstream of mitochondrial apoptosis involving Apaf-1.
Journal of cell science 2006;119(Pt 19):3958-66.
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2006: Yoshida T; Hisamoto T; Akiba J; Koga H; Nakamura K; Tokunaga Y; Hanada S; Kumemura H; Maeyama M; Harada M; Ogata H; Yano H; Kojiro M; Ueno T; Yoshimura A; Sata M
Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors.
Oncogene 2006;25(45):6056-66.
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2006: Takaki Hiromi; Minoda Yasumasa; Koga Keiko; Takaesu Giichi; Yoshimura Akihiko; Kobayashi Takashi
TGF-beta1 suppresses IFN-gamma-induced NO production in macrophages by suppressing STAT1 activation and accelerating iNOS protein degradation.
Genes to cells : devoted to molecular & cellular mechanisms 2006;11(8):871-82.
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2006: Ogata Hisanobu; Kobayashi Takashi; Chinen Takatoshi; Takaki Hiromi; Sanada Takahito; Minoda Yasumasa; Koga Keiko; Takaesu Giichi; Maehara Yoshihiko; Iida Mitsuo; Yoshimura Akihiko
Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis.
Gastroenterology 2006;131(1):179-93.
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2006: Yamagishi Sho-ichi; Nakamura Kazuo; Matsui Takanori; Inagaki Yosuke; Takenaka Katsuhiko; Jinnouchi Yuko; Yoshida Yumiko; Matsuura Tetsuro; Narama Isao; Motomiya Yoshihiro; Takeuchi Masayoshi; Inoue Hiroyoshi; Yoshimura Akihiko; Bucala Richard; Imaizumi Tsutomu
Pigment epithelium-derived factor inhibits advanced glycation end product-induced retinal vascular hyperpermeability by blocking reactive oxygen species-mediated vascular endothelial growth factor expression.
The Journal of biological chemistry 2006;281(29):20213-20.
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2006: Yoshimura Akihiko
Signal transduction of inflammatory cytokines and tumor development.
Cancer science 2006;97(6):439-47.
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2006: Hanada Toshikatsu; Kobayashi Takashi; Chinen Takatoshi; Saeki Kazuko; Takaki Hiromi; Koga Keiko; Minoda Yasumasa; Sanada Takahito; Yoshioka Tomoko; Mimata Hiromitsu; Kato Seiya; Yoshimura Akihiko
IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice.
The Journal of experimental medicine 2006;203(6):1391-7.
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2006: Minoda Yasumasa; Saeki Kazuko; Aki Daisuke; Takaki Hiromi; Sanada Takahito; Koga Keiko; Kobayashi Takashi; Takaesu Giichi; Yoshimura Akihiko
A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling.
Biochemical and biophysical research communications 2006;344(3):1023-30.
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2006: Moriyama Maiko; Fukuyama Satoru; Inoue Hiromasa; Matsumoto Takafumi; Sato Takahiro; Tanaka Kentaro; Kinjyo Ichiko; Kano Tatsuhiko; Yoshimura Akihiko; Kojima Masayasu
The neuropeptide neuromedin U activates eosinophils and is involved in allergen-induced eosinophilia.
American journal of physiology. Lung cellular and molecular physiology 2006;290(5):L971-7.
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2006: Kinjyo Ichiko; Inoue Hiromasa; Hamano Shinjiro; Fukuyama Satoru; Yoshimura Takeru; Koga Keiko; Takaki Hiromi; Himeno Kunisuke; Takaesu Giichi; Kobayashi Takashi; Yoshimura Akihiko
Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1.
The Journal of experimental medicine 2006;203(4):1021-31.
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2006: Ogata H; Chinen T; Yoshida T; Kinjyo I; Takaesu G; Shiraishi H; Iida M; Kobayashi T; Yoshimura A
Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-beta1 production.
Oncogene 2006;25(17):2520-30.
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2006: Moriyama Maiko; Matsukawa Akihiro; Kudoh Shinji; Takahashi Tomoko; Sato Takahiro; Kano Tatsuhiko; Yoshimura Akihiko; Kojima Masayasu
The neuropeptide neuromedin U promotes IL-6 production from macrophages and endotoxin shock.
Biochemical and biophysical research communications 2006;341(4):1149-54.
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2006: Chinen Takatoshi; Kobayashi Takashi; Ogata Hisanobu; Takaesu Giichi; Takaki Hiromi; Hashimoto Masayuki; Yagita Hideo; Nawata Hajime; Yoshimura Akihiko
Suppressor of cytokine signaling-1 regulates inflammatory bowel disease in which both IFNgamma and IL-4 are involved.
Gastroenterology 2006;130(2):373-88.
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2006: Ni R; Ihara K; Miyako K; Takemoto M; Ishimura M; Kohno H; Matsuura N; Yoshimura A; Hara T
Association study of polymorphisms in SOCS family genes with type 1 diabetes mellitus.
International journal of immunogenetics 2006;33(1):7-10.
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2006: Okumura Akiko Joo; Hatsuzawa Kiyotaka; Tamura Taku; Nagaya Hisao; Saeki Kazuko; Okumura Fumihiko; Nagao Kenji; Nishikawa Mitsuo; Yoshimura Akihiko; Wada Ikuo
Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system.
The Journal of biological chemistry 2006;281(7):4495-506.
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2006: Inagaki-Ohara K; Sasaki A; Matsuzaki G; Ikeda T; Hotokezaka M; Chijiiwa K; Kubo M; Yoshida H; Nawa Y; Yoshimura A
Suppressor of cytokine signalling 1 in lymphocytes regulates the development of intestinal inflammation in mice.
Gut 2006;55(2):212-9.
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2006: Shouda Takanori; Hiraoka Koji; Komiya Setsuro; Hamada Tetsuya; Zenmyo Michihisa; Iwasaki Hiroshi; Isayama Teruto; Fukushima Nobuhiro; Nagata Kensei; Yoshimura Akihiko
Suppression of IL-6 production and proliferation by blocking STAT3 activation in malignant soft tissue tumor cells.
Cancer letters 2006;231(2):176-84.
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2006: Sekine Yuichi; Yumioka Taro; Yamamoto Tetsuya; Muromoto Ryuta; Imoto Seiyu; Sugiyma Kenji; Oritani Kenji; Shimoda Kazuya; Minoguchi Mayu; Akira Shizuo; Yoshimura Akihiko; Matsuda Tadashi
Modulation of TLR4 signaling by a novel adaptor protein signal-transducing adaptor protein-2 in macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(1):380-9.
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2005: Mashima Ryuichi; Saeki Kazuko; Aki Daisuke; Minoda Yasumasa; Takaki Hiromi; Sanada Takahito; Kobayashi Takashi; Aburatani Hiroyuki; Yamanashi Yuji; Yoshimura Akihiko
FLN29, a novel interferon- and LPS-inducible gene acting as a negative regulator of toll-like receptor signaling.
The Journal of biological chemistry 2005;280(50):41289-97.
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2005: Nonami Atsushi; Taketomi Takaharu; Kimura Akiko; Saeki Kazuko; Takaki Hiromi; Sanada Takahito; Taniguchi Koji; Harada Mine; Kato Reiko; Yoshimura Akihiko
The Sprouty-related protein, Spred-1, localizes in a lipid raft/caveola and inhibits ERK activation in collaboration with caveolin-1.
Genes to cells : devoted to molecular & cellular mechanisms 2005;10(9):887-95.
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2005: Moriyama Maiko; Sato Takahiro; Inoue Hiromasa; Fukuyama Satoru; Teranishi Hitoshi; Kangawa Kenji; Kano Tatsuhiko; Yoshimura Akihiko; Kojima Masayasu
The neuropeptide neuromedin U promotes inflammation by direct activation of mast cells.
The Journal of experimental medicine 2005;202(2):217-24.
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2005: Taketomi Takaharu; Yoshiga Daigo; Taniguchi Koji; Kobayashi Takashi; Nonami Atsushi; Kato Reiko; Sasaki Mika; Sasaki Atsuo; Ishibashi Hitoshi; Moriyama Maiko; Nakamura Kei-ichiro; Nishimura Junji; Yoshimura Akihiko
Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia.
Nature neuroscience 2005;8(7):855-7.
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2005: Takeda Atsunobu; Hamano Shinjiro; Shiraishi Hiroshi; Yoshimura Takeru; Ogata Hisanobu; Ishii Kazunari; Ishibashi Tatsuro; Yoshimura Akihiko; Yoshida Hiroki
WSX-1 over-expression in CD4(+) T cells leads to hyperproliferation and cytokine hyperproduction in response to TCR stimulation.
International immunology 2005;17(7):889-97.
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2005: Yoshimura Akihiko
Negative regulation of cytokine signaling.
Clinical reviews in allergy & immunology 2005;28(3):205-20.
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2005: Yoshimura Akihiko; Sanada Masato; Mashima Ryuichi
[Receptor tyrosine kinases (c-kit, c-fmns, Flt-3, Tie2, etc.)]
Nippon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 4():207-14.
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2005: Kobayashi Takashi; Yoshimura Akihiko
Keeping DCs awake by putting SOCS1 to sleep.
Trends in immunology 2005;26(4):177-9.
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2005: Hanada Toshikatsu; Tanaka Kentaro; Matsumura Yumiko; Yamauchi Moriyasu; Nishinakamura Hitomi; Aburatani Hiroyuki; Mashima Ryuichi; Kubo Masato; Kobayashi Takashi; Yoshimura Akihiko
Induction of hyper Th1 cell-type immune responses by dendritic cells lacking the suppressor of cytokine signaling-1 gene.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(7):4325-32.
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2005: Aki Daisuke; Mashima Ryuichi; Saeki Kazuko; Minoda Yasumasa; Yamauchi Moriyasu; Yoshimura Akihiko
Modulation of TLR signalling by the C-terminal Src kinase (Csk) in macrophages.
Genes to cells : devoted to molecular & cellular mechanisms 2005;10(4):357-68.
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2005: Ohishi Masanobu; Matsumura Yumiko; Aki Daisuke; Mashima Ryuichi; Taniguchi Koji; Kobayashi Takashi; Kukita Toshio; Iwamoto Yukihide; Yoshimura Akihiko
Suppressors of cytokine signaling-1 and -3 regulate osteoclastogenesis in the presence of inflammatory cytokines.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(5):3024-31.
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2005: Sekine Yuichi; Yamamoto Tetsuya; Yumioka Taro; Sugiyama Kenji; Tsuji Satoshi; Oritani Kenji; Shimoda Kazuya; Minoguchi Mayu; Yoshimura Akihiko; Matsuda Tadashi
Physical and functional interactions between STAP-2/BKS and STAT5.
The Journal of biological chemistry 2005;280(9):8188-96.
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2005: Inoue Hiromasa; Kato Reiko; Fukuyama Satoru; Nonami Atsushi; Taniguchi Kouji; Matsumoto Koichiro; Nakano Takako; Tsuda Miyuki; Matsumura Mikiko; Kubo Masato; Ishikawa Fumihiko; Moon Byoung-gon; Takatsu Kiyoshi; Nakanishi Yoichi; Yoshimura Akihiko
Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness.
The Journal of experimental medicine 2005;201(1):73-82.
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2005: Yoshimura Akihiko; Nishinakamura Hitomi; Matsumura Yumiko; Hanada Toshikatsu
Negative regulation of cytokine signaling and immune responses by SOCS proteins.
Arthritis research & therapy 2005;7(3):100-10.
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2004: Takagi Hiromi; Sanada Takahito; Minoda Yasumasa; Yoshimura Akihiko
[Regulation of cytokine and toll-like receptor signaling by SOCS family genes]
Nippon rinsho. Japanese journal of clinical medicine 2004;62(12):2189-96.
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2004: Yamagishi Sho-ichi; Abe Riichiro; Inagaki Yosuke; Nakamura Kazuo; Sugawara Hiroshi; Inokuma Daisuke; Nakamura Hideki; Shimizu Tadamichi; Takeuchi Masayoshi; Yoshimura Akihiko; Bucala Richard; Shimizu Hiroshi; Imaizumi Tsutomu
Minodronate, a newly developed nitrogen-containing bisphosphonate, suppresses melanoma growth and improves survival in nude mice by blocking vascular endothelial growth factor signaling.
The American journal of pathology 2004;165(6):1865-74.
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2004: Nonami Atsushi; Kato Reiko; Taniguchi Koji; Yoshiga Daigo; Taketomi Takaharu; Fukuyama Satoru; Harada Mine; Sasaki Atsuo; Yoshimura Akihiko
Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells.
The Journal of biological chemistry 2004;279(50):52543-51.
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2004: Kawaguchi Takumi; Yoshida Takafumi; Harada Masaru; Hisamoto Takao; Nagao Yumiko; Ide Tatsuya; Taniguchi Eitaro; Kumemura Hiroto; Hanada Shinichiro; Maeyama Michiko; Baba Shinji; Koga Hironori; Kumashiro Ryukichi; Ueno Takato; Ogata Hisanobu; Yoshimura Akihiko; Sata Michio
Hepatitis C virus down-regulates insulin receptor substrates 1 and 2 through up-regulation of suppressor of cytokine signaling 3.
The American journal of pathology 2004;165(5):1499-508.
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2004: Yamagishi Sho-Ichi; Inagaki Yosuke; Nakamura Kazuo; Abe Riichiro; Shimizu Tadamichi; Yoshimura Akihiko; Imaizumi Tsutomu
Pigment epithelium-derived factor inhibits TNF-alpha-induced interleukin-6 expression in endothelial cells by suppressing NADPH oxidase-mediated reactive oxygen species generation.
Journal of molecular and cellular cardiology 2004;37(2):497-506.
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2004: Inagaki-Ohara Kyoko; Chinen Takatoshi; Matsuzaki Goro; Sasaki Atsuo; Sakamoto Yukiko; Hiromatsu Kenji; Nakamura-Uchiyama Fukumi; Nawa Yukifumi; Yoshimura Akihiko
Mucosal T cells bearing TCRgammadelta play a protective role in intestinal inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(2):1390-8.
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2004: Mori Hiroyuki; Hanada Reiko; Hanada Toshikatsu; Aki Daisuke; Mashima Ryuichi; Nishinakamura Hitomi; Torisu Takehiro; Chien Kenneth R; Yasukawa Hideo; Yoshimura Akihiko
Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity.
Nature medicine 2004;10(7):739-43.
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2004: Miyoshi Kanta; Wakioka Toru; Nishinakamura Hitomi; Kamio Masaki; Yang Lu; Inoue Makoto; Hasegawa Mamoru; Yonemitsu Yoshikazu; Komiya Setsuro; Yoshimura Akihiko
The Sprouty-related protein, Spred, inhibits cell motility, metastasis, and Rho-mediated actin reorganization.
Oncogene 2004;23(33):5567-76.
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2004: Yoshida Takafumi; Ogata Hisanobu; Kamio Masaki; Joo Akiko; Shiraishi Hiroshi; Tokunaga Yoko; Sata Michio; Nagai Hisaki; Yoshimura Akihiko
SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis.
The Journal of experimental medicine 2004;199(12):1701-7.
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2004: Kamio Masaki; Yoshida Takafumi; Ogata Hisanobu; Douchi Tsutomu; Nagata Yukihiro; Inoue Makoto; Hasegawa Mamoru; Yonemitsu Yoshikazu; Yoshimura Akihiko
SOCS1 [corrected] inhibits HPV-E7-mediated transformation by inducing degradation of E7 protein.
Oncogene 2004;23(17):3107-15.
-
2004: Gatto Luana; Berlato Chiara; Poli Valeria; Tininini Silvia; Kinjyo Ichiko; Yoshimura Akihiko; Cassatella Marco A; Bazzoni Flavia
Analysis of SOCS-3 promoter responses to interferon gamma.
The Journal of biological chemistry 2004;279(14):13746-54.
-
2004: Yamanaka Atsushi; Hamano Shinjiro; Miyazaki Yoshiyuki; Ishii Kazunari; Takeda Atsunobu; Mak Tak W; Himeno Kunisuke; Yoshimura Akihiko; Yoshida Hiroki
Hyperproduction of proinflammatory cytokines by WSX-1-deficient NKT cells in concanavalin A-induced hepatitis.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(6):3590-6.
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2004: Yoshimura Akihiko; Ohishi Hiroyuki Mori Masanobu; Aki Daisuke; Hanada Toshikatsu
Regulation of TLR signaling and inflammation by SOCS family proteins.
Journal of leukocyte biology 2004;75(3):422-7.
-
2004: Kimura Akiko; Kinjyo Ichiko; Matsumura Yumiko; Mori Hiroyuki; Mashima Ryuichi; Harada Mine; Chien Kenneth R; Yasukawa Hideo; Yoshimura Akihiko
SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony-stimulating factor receptor signaling.
The Journal of biological chemistry 2004;279(8):6905-10.
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2004: Joo Akiko; Aburatani Hiroyuki; Morii Eiichi; Iba Hideo; Yoshimura Akihiko
STAT3 and MITF cooperatively induce cellular transformation through upregulation of c-fos expression.
Oncogene 2004;23(3):726-34.
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2003: Yoshimura Akihiko; Mori Hiroyuki; Ohishi Masanobu; Aki Daisuke; Hanada Toshikatsu
Negative regulation of cytokine signaling influences inflammation.
Current opinion in immunology 2003;15(6):704-8.
-
2003: Hamano Shinjiro; Himeno Kunisuke; Miyazaki Yoshiyuki; Ishii Kazunari; Yamanaka Atsushi; Takeda Atsunobu; Zhang Manxin; Hisaeda Hajime; Mak Tak W; Yoshimura Akihiko; Yoshida Hiroki
WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production.
Immunity 2003;19(5):657-67.
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2003: Hanada Toshikatsu; Yoshida Hiroki; Kato Seiya; Tanaka Kentaro; Masutani Kohsuke; Tsukada Jun; Nomura Yoshio; Mimata Hiromitsu; Kubo Masato; Yoshimura Akihiko
Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity.
Immunity 2003;19(3):437-50.
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2003: Inagaki-Ohara Kyoko; Hanada Toshikatsu; Yoshimura Akihiko
Negative regulation of cytokine signaling and inflammatory diseases.
Current opinion in pharmacology 2003;3(4):435-42.
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2003: Seki Yoh-ichi; Inoue Hiromasa; Nagata Naoko; Hayashi Katsuhiko; Fukuyama Satoru; Matsumoto Koichiro; Komine Okiru; Hamano Shinjiro; Himeno Kunisuke; Inagaki-Ohara Kyoko; Cacalano Nicholas; O'Garra Anne; Oshida Tadahilo; Saito Hirohisa; Johnston James A; Yoshimura Akihiko; Kubo Masato
SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses.
Nature medicine 2003;9(8):1047-54.
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2003: Sasaki Atsuo; Taketomi Takaharu; Kato Reiko; Saeki Kazuko; Nonami Atsushi; Sasaki Mika; Kuriyama Masamitsu; Saito Naoaki; Shibuya Masafumi; Yoshimura Akihiko
Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.
Cell cycle (Georgetown, Tex.) 2003;2(4):281-2.
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2003: Yamamoto Tetsuya; Yumioka Taro; Sekine Yuichi; Sato Noriko; Minoguchi Mayu; Yoshimura Akihiko; Matsuda Tadashi
Regulation of FcepsilonRI-mediated signaling by an adaptor protein STAP-2/BSK in rat basophilic leukemia RBL-2H3 cells.
Biochemical and biophysical research communications 2003;306(3):767-73.
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2003: Saeki Kazuko; Miura Yoshiki; Aki Daisuke; Kurosaki Tomohiro; Yoshimura Akihiko
The B cell-specific major raft protein, Raftlin, is necessary for the integrity of lipid raft and BCR signal transduction.
The EMBO journal 2003;22(12):3015-26.
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2003: Yasukawa Hideo; Ohishi Masanobu; Mori Hiroyuki; Murakami Masaaki; Chinen Takatoshi; Aki Daisuke; Hanada Toshikatsu; Takeda Kiyoshi; Akira Shizuo; Hoshijima Masahiko; Hirano Toshio; Chien Kenneth R; Yoshimura Akihiko
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages.
Nature immunology 2003;4(6):551-6.
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2003: Shibata Rei; Kai Hisashi; Seki Yukihiko; Kato Seiya; Wada Yoshihiro; Hanakawa Yasushi; Hashimoto Koji; Yoshimura Akihiko; Imaizumi Tsutomu
Inhibition of STAT3 prevents neointima formation by inhibiting proliferation and promoting apoptosis of neointimal smooth muscle cells.
Human gene therapy 2003;14(7):601-10.
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2003: Takeda Atsunobu; Hamano Shinjiro; Yamanaka Atsushi; Hanada Toshikatsu; Ishibashi Tatsuro; Mak Tak W; Yoshimura Akihiko; Yoshida Hiroki
Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(10):4886-90.
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2003: Sasaki Atsuo; Taketomi Takaharu; Kato Reiko; Saeki Kazuko; Nonami Atsushi; Sasaki Mika; Kuriyama Masamitsu; Saito Naoaki; Shibuya Masabumi; Yoshimura Akihiko
Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.
Nature cell biology 2003;5(5):427-32.
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2003: Nagata Tsuyoshi; Kai Hisashi; Shibata Rei; Koga Mitsuhisa; Yoshimura Akihiko; Imaizumi Tsutomu
Oncostatin M, an interleukin-6 family cytokine, upregulates matrix metalloproteinase-9 through the mitogen-activated protein kinase kinase-extracellular signal-regulated kinase pathway in cultured smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(4):588-93.
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2003: Kato Reiko; Nonami Atsushi; Taketomi Takaharu; Wakioka Toru; Kuroiwa Asato; Matsuda Yoichi; Yoshimura Akihiko
Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation.
Biochemical and biophysical research communications 2003;302(4):767-72.
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2003: Minoguchi Mayu; Minoguchi Shigeru; Aki Daisuke; Joo Akiko; Yamamoto Tetsuya; Yumioka Taro; Matsuda Tadashi; Yoshimura Akihiko
STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif.
The Journal of biological chemistry 2003;278(13):11182-9.
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2003: Matsumoto Akira; Seki Yoh-ichi; Watanabe Ryosuke; Hayashi Katsuhiko; Johnston James A; Harada Yohsuke; Abe Ryo; Yoshimura Akihiko; Kubo Masato
A role of suppressor of cytokine signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediated interleukin 2 production.
The Journal of experimental medicine 2003;197(4):425-36.
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2003: Minoguchi Shigeru; Minoguchi Mayu; Yoshimura Akihiko
Differential control of the NIMA-related kinases, Nek6 and Nek7, by serum stimulation.
Biochemical and biophysical research communications 2003;301(4):899-906.
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2003: Endo Takaho; Sasaki Atsuo; Minoguchi Mayu; Joo Akiko; Yoshimura Akihiko
CIS1 interacts with the Y532 of the prolactin receptor and suppresses prolactin-dependent STAT5 activation.
Journal of biochemistry 2003;133(1):109-13.
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2003: Sasaki Atsuo; Inagaki-Ohara Kyoko; Yoshida Takafumi; Yamanaka Atsushi; Sasaki Mika; Yasukawa Hideo; Koromilas Antonis E; Yoshimura Akihiko
The N-terminal truncated isoform of SOCS3 translated from an alternative initiation AUG codon under stress conditions is stable due to the lack of a major ubiquitination site, Lys-6.
The Journal of biological chemistry 2003;278(4):2432-6.
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2003: Hanada T; Kinjyo I; Inagaki-Ohara K; Yoshimura A
Negative regulation of cytokine signaling by CIS/SOCS family proteins and their roles in inflammatory diseases.
Reviews of physiology, biochemistry and pharmacology 2003;149():72-86.
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2002: Okamoto Tamami; Yamagishi Sho-ichi; Inagaki Yosuke; Amano Shinjiro; Koga Kohachiro; Abe Riichiro; Takeuchi Masayoshi; Ohno Shigeaki; Yoshimura Akihiko; Makita Zenji
Angiogenesis induced by advanced glycation end products and its prevention by cerivastatin.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(14):1928-30.
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2002: Kinjyo Ichiko; Hanada Toshikatsu; Inagaki-Ohara Kyoko; Mori Hiroyuki; Aki Daisuke; Ohishi Masanobu; Yoshida Hiroki; Kubo Masato; Yoshimura Akihiko
SOCS1/JAB is a negative regulator of LPS-induced macrophage activation.
Immunity 2002;17(5):583-91.
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2002: Seki Yoh-Ichi; Hayashi Katsuhiko; Matsumoto Akira; Seki Noriyasu; Tsukada Jun; Ransom John; Naka Tetsuji; Kishimoto Tadamitsu; Yoshimura Akihiko; Kubo Masato
Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(20):13003-8.
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2002: Okamoto Tamami; Yamagishi Sho-ichi; Inagaki Yosuke; Amano Shinjiro; Takeuchi Masayoshi; Kikuchi Seiji; Ohno Shigeaki; Yoshimura Akihiko
Incadronate disodium inhibits advanced glycation end products-induced angiogenesis in vitro.
Biochemical and biophysical research communications 2002;297(2):419-24.
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2002: Yoshida Takafumi; Hanada Toshikatsu; Tokuhisa Takeshi; Kosai Ken-ichiro; Sata Michio; Kohara Michinori; Yoshimura Akihiko
Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation.
The Journal of experimental medicine 2002;196(5):641-53.
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2002: Hanada Toshitkatsu; Yoshimura Akihiko
Regulation of cytokine signaling and inflammation.
Cytokine & growth factor reviews 2002;13(4-5):413-21.
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2002: Berlato Chiara; Cassatella Marco A; Kinjyo Ichiko; Gatto Luana; Yoshimura Akihiko; Bazzoni Flavia
Involvement of suppressor of cytokine signaling-3 as a mediator of the inhibitory effects of IL-10 on lipopolysaccharide-induced macrophage activation.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(12):6404-11.
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2002: Ohtsuka Satoshi; Takaki Satoshi; Iseki Masanori; Miyoshi Kanta; Nakagata Naomi; Kataoka Yuki; Yoshida Nobuaki; Takatsu Kiyoshi; Yoshimura Akihiko
SH2-B is required for both male and female reproduction.
Molecular and cellular biology 2002;22(9):3066-77.
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2002: Hara Hiromitsu; Takeda Atsunobu; Takeuchi Michiyo; Wakeham Andrew C; Itié Annick; Sasaki Masafumi; Mak Tak W; Yoshimura Akihiko; Nomoto Kikuo; Yoshida Hiroki
The apoptotic protease-activating factor 1-mediated pathway of apoptosis is dispensable for negative selection of thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(5):2288-95.
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2002: Gasperini Sara; Crepaldi Luca; Calzetti Federica; Gatto Luana; Berlato Chiara; Bazzoni Flavia; Yoshimura Akihiko; Cassatella Marco A
Interleukin-10 and cAMP-elevating agents cooperate to induce suppressor of cytokine signaling-3 via a protein kinase A-independent signal.
European cytokine network 2002;13(1):47-53.
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2001: Shouda T; Yoshida T; Hanada T; Wakioka T; Oishi M; Miyoshi K; Komiya S; Kosai K; Hanakawa Y; Hashimoto K; Nagata K; Yoshimura A
Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis.
The Journal of clinical investigation 2001;108(12):1781-8.
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2001: Hanada T; Yoshida T; Kinjyo I; Minoguchi S; Yasukawa H; Kato S; Mimata H; Nomura Y; Seki Y; Kubo M; Yoshimura A
A mutant form of JAB/SOCS1 augments the cytokine-induced JAK/STAT pathway by accelerating degradation of wild-type JAB/CIS family proteins through the SOCS-box.
The Journal of biological chemistry 2001;276(44):40746-54.
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2001: Sasaki A; Taketomi T; Wakioka T; Kato R; Yoshimura A
Identification of a dominant negative mutant of Sprouty that potentiates fibroblast growth factor- but not epidermal growth factor-induced ERK activation.
The Journal of biological chemistry 2001;276(39):36804-8.
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2001: Wakioka T; Sasaki A; Kato R; Shouda T; Matsumoto A; Miyoshi K; Tsuneoka M; Komiya S; Baron R; Yoshimura A
Spred is a Sprouty-related suppressor of Ras signalling.
Nature 2001;412(6847):647-51.
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2001: Kamizono S; Hanada T; Yasukawa H; Minoguchi S; Kato R; Minoguchi M; Hattori K; Hatakeyama S; Yada M; Morita S; Kitamura T; Kato H; Nakayama Ki; Yoshimura A
The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2.
The Journal of biological chemistry 2001;276(16):12530-8.
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2001: Suzuki A; Hanada T; Mitsuyama K; Yoshida T; Kamizono S; Hoshino T; Kubo M; Yamashita A; Okabe M; Takeda K; Akira S; Matsumoto S; Toyonaga A; Sata M; Yoshimura A
CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation.
The Journal of experimental medicine 2001;193(4):471-81.
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2000: Sakamoto H; Kitamura T; Yoshimura A
Mitogen-activated protein kinase plays an essential role in the erythropoietin-dependent proliferation of CTLL-2 cells.
The Journal of biological chemistry 2000;275(46):35857-62.
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2000: Sasaki A; Yasukawa H; Shouda T; Kitamura T; Dikic I; Yoshimura A
CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2.
The Journal of biological chemistry 2000;275(38):29338-47.
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2000: Seki Y; Kai H; Shibata R; Nagata T; Yasukawa H; Yoshimura A; Imaizumi T
Role of the JAK/STAT pathway in rat carotid artery remodeling after vascular injury.
Circulation research 2000;87(1):12-8.
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2000: Supino-Rosin L; Yoshimura A; Yarden Y; Elazar Z; Neumann D
Intracellular retention and degradation of the epidermal growth factor receptor, two distinct processes mediated by benzoquinone ansamycins.
The Journal of biological chemistry 2000;275(29):21850-5.
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2000: Sakamoto H; Kinjyo I; Yoshimura A
The janus kinase inhibitor, Jab/SOCS-1, is an interferon-gamma inducible gene and determines the sensitivity to interferons.
Leukemia & lymphoma 2000;38(1-2):49-58.
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2000: Yoshimura A
[Signal transduction of cytokine receptors and its regulation]
Seikagaku. The Journal of Japanese Biochemical Society 2000;72(2):75-90.
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2000: Masuhara M; Nagao K; Nishikawa M; Sasaki M; Yoshimura A; Osawa M
Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains.
Biochemical and biophysical research communications 2000;268(3):697-703.
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2000: Yasukawa H; Sasaki A; Yoshimura A
Negative regulation of cytokine signaling pathways.
Annual review of immunology 2000;18():143-64.
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1999: Mitsui K; Nakanishi M; Ohtsuka S; Norwood T H; Okabayashi K; Miyamoto C; Tanaka K; Yoshimura A; Ohtsubo M
A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins.
Biochemical and biophysical research communications 1999;266(1):115-22.
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1999: Mitsui K; Matsumoto A; Ohtsuka S; Ohtsubo M; Yoshimura A
Cloning and characterization of a novel p21(Cip1/Waf1)-interacting zinc finger protein, ciz1.
Biochemical and biophysical research communications 1999;264(2):457-64.
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1999: Cassatella M A; Gasperini S; Bovolenta C; Calzetti F; Vollebregt M; Scapini P; Marchi M; Suzuki R; Suzuki A; Yoshimura A
Interleukin-10 (IL-10) selectively enhances CIS3/SOCS3 mRNA expression in human neutrophils: evidence for an IL-10-induced pathway that is independent of STAT protein activation.
Blood 1999;94(8):2880-9.
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1999: Matsumoto A; Seki Y; Kubo M; Ohtsuka S; Suzuki A; Hayashi I; Tsuji K; Nakahata T; Okabe M; Yamada S; Yoshimura A
Suppression of STAT5 functions in liver, mammary glands, and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice.
Molecular and cellular biology 1999;19(9):6396-407.
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1999: Ashikari M; Wu J; Yano M; Sasaki T; Yoshimura A
Rice gibberellin-insensitive dwarf mutant gene Dwarf 1 encodes the alpha-subunit of GTP-binding protein.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(18):10284-9.
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1999: Supino-Rosin L; Yoshimura A; Altaratz H; Neumann D
A cytosolic domain of the erythropoietin receptor contributes to endoplasmic reticulum-associated degradation.
European journal of biochemistry / FEBS 1999;263(2):410-9.
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1999: Sasaki A; Yasukawa H; Suzuki A; Kamizono S; Syoda T; Kinjyo I; Sasaki M; Johnston J A; Yoshimura A
Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain.
Genes to cells : devoted to molecular & cellular mechanisms 1999;4(6):339-51.
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1999: Wakioka T; Sasaki A; Mitsui K; Yokouchi M; Inoue A; Komiya S; Yoshimura A
APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1999;13(5):760-7.
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1999: Ding S; Kuroki S; Kameyama A; Yoshimura A; Kameyama M
Cloning and expression of the Ca2+ channel alpha1C and beta2a subunits from guinea pig heart.
Journal of biochemistry 1999;125(4):750-9.
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1999: Tanimura S; Ohtsuka S; Mitsui K; Shirouzu K; Yoshimura A; Ohtsubo M
MDM2 interacts with MDMX through their RING finger domains.
FEBS letters 1999;447(1):5-9.
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1999: Yasukawa H; Misawa H; Sakamoto H; Masuhara M; Sasaki A; Wakioka T; Ohtsuka S; Imaizumi T; Matsuda T; Ihle J N; Yoshimura A
The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop.
The EMBO journal 1999;18(5):1309-20.
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1999: Yokouchi M; Wakioka T; Sakamoto H; Yasukawa H; Ohtsuka S; Sasaki A; Ohtsubo M; Valius M; Inoue A; Komiya S; Yoshimura A
APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis.
Oncogene 1999;18(3):759-67.
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1998: Yoshimura A
The CIS/JAB family: novel negative regulators of JAK signaling pathways.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1998;12(12):1851-7.
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1998: Suzuki R; Sakamoto H; Yasukawa H; Masuhara M; Wakioka T; Sasaki A; Yuge K; Komiya S; Inoue A; Yoshimura A
CIS3 and JAB have different regulatory roles in interleukin-6 mediated differentiation and STAT3 activation in M1 leukemia cells.
Oncogene 1998;17(17):2271-8.
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1998: Yoshimura A
The CIS family: negative regulators of JAK-STAT signaling.
Cytokine & growth factor reviews 1998;9(3-4):197-204.
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1998: Sakamoto H; Yasukawa H; Masuhara M; Tanimura S; Sasaki A; Yuge K; Ohtsubo M; Ohtsuka A; Fujita T; Ohta T; Furukawa Y; Iwase S; Yamada H; Yoshimura A
A Janus kinase inhibitor, JAB, is an interferon-gamma-inducible gene and confers resistance to interferons.
Blood 1998;92(5):1668-76.
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1998: Yoshimura A; Misawa H
Physiology and function of the erythropoietin receptor.
Current opinion in hematology 1998;5(3):171-6.
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1998: Levin I; Cohen J; Supino-Rosin L; Yoshimura A; Watowich S S; Neumann D
Identification of a cytoplasmic motif in the erythropoietin receptor required for receptor internalization.
FEBS letters 1998;427(2):164-70.
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1998: Misawa H; Ohtsubo M; Copeland N G; Gilbert D J; Jenkins N A; Yoshimura A
Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain.
Biochemical and biophysical research communications 1998;244(2):531-9.
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1997: Masuhara M; Sakamoto H; Matsumoto A; Suzuki R; Yasukawa H; Mitsui K; Wakioka T; Tanimura S; Sasaki A; Misawa H; Yokouchi M; Ohtsubo M; Yoshimura A
Cloning and characterization of novel CIS family genes.
Biochemical and biophysical research communications 1997;239(2):439-46.
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1997: Yokouchi M; Suzuki R; Masuhara M; Komiya S; Inoue A; Yoshimura A
Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation.
Oncogene 1997;15(1):7-15.
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1997: Endo T A; Masuhara M; Yokouchi M; Suzuki R; Sakamoto H; Mitsui K; Matsumoto A; Tanimura S; Ohtsubo M; Misawa H; Miyazaki T; Leonor N; Taniguchi T; Fujita T; Kanakura Y; Komiya S; Yoshimura A
A new protein containing an SH2 domain that inhibits JAK kinases.
Nature 1997;387(6636):921-4.
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1997: Matsumoto A; Masuhara M; Mitsui K; Yokouchi M; Ohtsubo M; Misawa H; Miyajima A; Yoshimura A
CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation.
Blood 1997;89(9):3148-54.
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1997: Iwatsuki K; Endo T; Misawa H; Yokouchi M; Matsumoto A; Ohtsubo M; Mori K J; Yoshimura A
STAT5 activation correlates with erythropoietin receptor-mediated erythroid differentiation of an erythroleukemia cell line.
The Journal of biological chemistry 1997;272(13):8149-52.
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1992: Yoshimura A; Zimmers T; Neumann D; Longmore G; Yoshimura Y; Lodish H F
Mutations in the Trp-Ser-X-Trp-Ser motif of the erythropoietin receptor abolish processing, ligand binding, and activation of the receptor.
The Journal of biological chemistry 1992;267(16):11619-25.
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1992: Watowich S S; Yoshimura A; Longmore G D; Hilton D J; Yoshimura Y; Lodish H F
Homodimerization and constitutive activation of the erythropoietin receptor.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(6):2140-4.
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1992: Yoshimura A; Lodish H F
In vitro phosphorylation of the erythropoietin receptor and an associated protein, pp130.
Molecular and cellular biology 1992;12(2):706-15.
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1992: Lodish H F; Hilton D; Longmore G; Watowich S S; Yoshimura A
The erythropoietin receptor: dimerization, activation, and tumorigenesis.
Cold Spring Harbor symposia on quantitative biology 1992;57():95-106.
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1991: D'Andrea A D; Yoshimura A; Youssoufian H; Zon L I; Koo J W; Lodish H F
The cytoplasmic region of the erythropoietin receptor contains nonoverlapping positive and negative growth-regulatory domains.
Molecular and cellular biology 1991;11(4):1980-7.
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1990: Yoshimura A; Longmore G; Lodish H F
Point mutation in the exoplasmic domain of the erythropoietin receptor resulting in hormone-independent activation and tumorigenicity.
Nature 1990;348(6302):647-9.
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1990: Yoshimura A; D'Andrea A D; Lodish H F
Friend spleen focus-forming virus glycoprotein gp55 interacts with the erythropoietin receptor in the endoplasmic reticulum and affects receptor metabolism.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(11):4139-43.
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