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Jeremy Brock

Research Profile

Chemicals & Drugs

Anatomy

Living Beings

Mouse

Procedures

Peritoneal Dialysis, Continuous Ambulatory

Physiology

Disorders

Rheumatoid Arthritis

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Publications

TOP 3
Jeremy H Brock
Lactoferrin--50 years on.
Mihaela Trif; Anca Roseanu; Jeremy H Brock; James M Brewer
Designing lipid nanostructures for local delivery of biologically active macromolecules.
Anca Roseanu; Jeremy H Brock
What are the structure and the biological function of lactoferrin in human breast milk?

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All Publications

2012: Jeremy H Brock
Lactoferrin--50 years on.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2012;90(3):245-51.
2007: Mihaela Trif; Anca Roseanu; Jeremy H Brock; James M Brewer
Designing lipid nanostructures for local delivery of biologically active macromolecules.
Journal of liposome research 2007;17(3-4):237-48.
2006: Anca Roseanu; Jeremy H Brock
What are the structure and the biological function of lactoferrin in human breast milk?
IUBMB life 2006;58(4):235-7.
2004: Joan F Telfer; Jeremy H Brock
Proinflammatory cytokines increase iron uptake into human monocytes and synovial fibroblasts from patients with rheumatoid arthritis.
Medical science monitor : international medical journal of experimental and clinical research 2004;10(4):BR91-5.
2003: Carol- Constantin Prunescu; Nicolae Serban-Parau; Jeremy H Brock; Diane M Vaughan; Paula Prunescu
Liver and kidney structure and iron content in romanian brown bears (Ursus arctos) before and after hibernation.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2003;134(1):21-6.
2002: Joan F Telfer; Jeremy H Brock
Expression of ferritin, transferrin receptor, and non-specific resistance associated macrophage proteins 1 and 2 (Nramp1 and Nramp2) in the human rheumatoid synovium.
Annals of the rheumatic diseases 2002;61(8):741-4.
2002: Victoriano Mulero; Xiao-Qing Wei; Foo Y Liew; Jeremy H Brock
Regulation of phagosomal iron release from murine macrophages by nitric oxide.
The Biochemical journal 2002;365(Pt 1):127-32.
2002: Edward J Fitzsimons; Tracey Houston; Robin Munro; Roger D Sturrock; Anthony B J Speekenbrink; Jeremy H Brock
Erythroblast iron metabolism and serum soluble transferrin receptor values in the anemia of rheumatoid arthritis.
Arthritis and rheumatism 2002;47(2):166-71.
2002: Cristina Guillén; Iain B McInnes; Diane M Vaughan; Sharada Kommajosyula; Patrick H C Van Berkel; Bernard P Leung; Antonio Aguila; Jeremy H Brock
Enhanced Th1 response to Staphylococcus aureus infection in human lactoferrin-transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(8):3950-7.
2002: Victoriano Mulero; Susan Searle; Jenefer M Blackwell; Jeremy H Brock
Solute carrier 11a1 (Slc11a1; formerly Nramp1) regulates metabolism and release of iron acquired by phagocytic, but not transferrin-receptor-mediated, iron uptake.
The Biochemical journal 2002;363(Pt 1):89-94.
2002: Jeremy H Brock
The physiology of lactoferrin.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2002;80(1):1-6.
2001: A Aguila; A G Herrera; D Morrison; B Cosgrove; A Perojo; I Montesinos; J Pérez; V.Gustavo Sierra; C G Gemmell; Jeremy H Brock
Bacteriostatic activity of human lactoferrin against Staphylococcus aureus is a function of its iron-binding properties and is not influenced by antibiotic resistance.
FEMS immunology and medical microbiology 2001;31(2):145-52.
2001: Mihaela Trif; C Guillen; Diane M Vaughan; J M Telfer; J M Brewer; Anca Roseanu; Jeremy H Brock
Liposomes as possible carriers for lactoferrin in the local treatment of inflammatory diseases.
Experimental biology and medicine (Maywood, N.J.) 2001;226(6):559-64.
2001: Edward J Fitzsimons; Jeremy H Brock
The anaemia of chronic disease.
BMJ (Clinical research ed.) 2001;322(7290):811-2.
2000: Jeremy H Brock; Victoriano Mulero
Cellular and molecular aspects of iron and immune function.
The Proceedings of the Nutrition Society 2000;59(4):537-40.
2000: C Guillen; Iain B McInnes; D Vaughan; A B Speekenbrink; Jeremy H Brock
The effects of local administration of lactoferrin on inflammation in murine autoimmune and infectious arthritis.
Arthritis and rheumatism 2000;43(9):2073-80.
2000: A Roşeanu; F Chelu; Mihaela Trif; C Motaş; Jeremy H Brock
Inhibition of binding of lactoferrin to the human promonocyte cell line THP-1 by heparin: the role of cell surface sulphated molecules.
Biochimica et biophysica acta 2000;1475(1):35-8.
1999: Jeremy H Brock
Benefits and dangers of iron during infection.
Current opinion in clinical nutrition and metabolic care 1999;2(6):507-10.
1999: Victoriano Mulero; Jeremy H Brock
Regulation of iron metabolism in murine J774 macrophages: role of nitric oxide-dependent and -independent pathways following activation with gamma interferon and lipopolysaccharide.
Blood 1999;94(7):2383-9.
1998: C Guillén; Iain B McInnes; H Kruger; Jeremy H Brock
Iron, lactoferrin and iron regulatory protein activity in the synovium; relative importance of iron loading and the inflammatory response.
Annals of the rheumatic diseases 1998;57(5):309-14.
1998: Jeremy H Brock; A Lamont; D J Boyle; E R Holme; Charles P McSharry; J E Bunn; Bo Lonnerdal
Antibodies to lactoferrin. A possible link between cow's milk intolerance and autoimmune disease.
Advances in experimental medicine and biology 1998;443():305-11.
1998: C Guillen; Iain B McInnes; Jeremy H Brock
Iron in synovial fluid. Removal by lactoferrin and relationship to iron regulatory protein (IRP) activity.
Advances in experimental medicine and biology 1998;443():161-5.
1997: Jeremy H Brock; A Lamont; D J Boyle; E R Holme; Charles P McSharry; J E Bunn; Bo Lonnerdal
Antibodies to lactoferrin--a possible link between cow's milk intolerance and autoimmune disease.
Biochemical Society transactions 1997;25(2):317S.
1997: C Guillen; Iain B McInnes; Jeremy H Brock
Iron in synovial fluid: removal by lactoferrin, and relationship to iron regulatory protein (IRP) activity.
Biochemical Society transactions 1997;25(2):315S.
1997: Jeremy H Brock; S Bhandari; E M Freel
Modulation of iron-regulatory protein (IRP) activity in monocytes by nitric oxide, phorbol ester and gamma-interferon.
Biochemical Society transactions 1997;25(2):193S.
1997: Günter Weiss; T Houston; S Kastner; Karin Jöhrer; Kurt Grünewald; Jeremy H Brock
Regulation of cellular iron metabolism by erythropoietin: activation of iron-regulatory protein and upregulation of transferrin receptor expression in erythroid cells.
Blood 1997;89(2):680-7.
1996: L Sánchez; M Ismail; Foo Y Liew; Jeremy H Brock
Iron transport across Caco-2 cell monolayers. Effect of transferrin, lactoferrin and nitric oxide.
Biochimica et biophysica acta 1996;1289(2):291-7.
1996: S J McGregor; Nicholas Topley; Achim Jörres; A B Speekenbrink; A Gordon; GM Gahl; B J Junor; J D Briggs; Jeremy H Brock
Longitudinal evaluation of peritoneal macrophage function and activation during CAPD: maturity, cytokine synthesis and arachidonic acid metabolism.
Kidney international 1996;49(2):525-33.
1995: R Oria; L Sánchez; T Houston; M W Hentze; F Y Liew; Jeremy H Brock
Effect of nitric oxide on expression of transferrin receptor and ferritin and on cellular iron metabolism in K562 human erythroleukemia cells.
Blood 1995;85(10):2962-6.
1995: A Djeha; J L Pérez-Arellano; S L Hayes; R Oria; R J Simpson; K B Raja; Jeremy H Brock
Cytokine-mediated regulation of transferrin synthesis in mouse macrophages and human T lymphocytes.
Blood 1995;85(4):1036-42.
1994: Jeremy H Brock; A Djeha; M Ismail; R Oria; R H Sinclair
Cellular responses to iron and iron compounds.
Advances in experimental medicine and biology 1994;356():91-100.
1994: L Sánchez; J M Peiró; R Oria; H Castillo; Jeremy H Brock; Miguel Calvo
Kinetic parameters for the heat denaturation of bovine lactoferrin in milk, and its effect on interaction with monocytes.
Advances in experimental medicine and biology 1994;357():253-7.
1994: Jeremy H Brock; M Ismail; L Sánchez
Interaction of lactoferrin with mononuclear and colon carcinoma cells.
Advances in experimental medicine and biology 1994;357():157-69.
1993: M Ismail; Jeremy H Brock
Binding of lactoferrin and transferrin to the human promonocytic cell line U937. Effect on iron uptake and release.
The Journal of biological chemistry 1993;268(29):21618-25.
1993: R Oria; M Ismail; L Sánchez; Miguel Calvo; Jeremy H Brock
Effect of heat treatment and other milk proteins on the interaction of lactoferrin with monocytes.
The Journal of dairy research 1993;60(3):363-9.
1993: A Djeha; J L Pérez-Arellano; Jeremy H Brock
Transferrin synthesis by mouse lymph node and peritoneal macrophages: iron content and effect on lymphocyte proliferation.
Blood 1993;81(4):1046-50.
1992: A Djeha; J L Pérez-Arellano; S L Hayes; Jeremy H Brock
Transferrin synthesis by macrophages: up-regulation by gamma-interferon and effect on lymphocyte proliferation.
FEMS microbiology immunology 1992;5(5-6):279-82.
1992: S J McGregor; Jeremy H Brock
Effect of pH and citrate on binding of iron and gallium by transferrin in serum.
Clinical chemistry 1992;38(9):1883-5.
1992: E R Rocha; Simon C Andrews; J N Keen; Jeremy H Brock
Isolation of a ferritin from Bacteroides fragilis.
FEMS microbiology letters 1992;74(2-3):207-12.
1992: L Sánchez; Miguel Calvo; Jeremy H Brock
Biological role of lactoferrin.
Archives of disease in childhood 1992;67(5):657-61.
1992: M Iturralde; J K Vass; R Oria; Jeremy H Brock
Effect of iron and retinoic acid on the control of transferrin receptor and ferritin in the human promonocytic cell line U937.
Biochimica et biophysica acta 1992;1133(3):241-6.
1992: A Djeha; Jeremy H Brock
Effect of transferrin, lactoferrin and chelated iron on human T-lymphocytes.
British journal of haematology 1992;80(2):235-41.
1992: A Djeha; Jeremy H Brock
Uptake and intracellular handling of iron from transferrin and iron chelates by mitogen stimulated mouse lymphocytes.
Biochimica et biophysica acta 1992;1133(2):147-52.
1991: N A Moughal; S J McGregor; Jeremy H Brock; J D Briggs; B J Junor
Expression of transferrin receptors by monocytes and peritoneal macrophages from renal failure patients treated by continuous ambulatory peritoneal dialysis (CAPD).
European journal of clinical investigation 1991;21(6):592-6.
1991: S J McGregor; M L Naves; A K Birly; N H Russell; D Halls; B J Junor; Jeremy H Brock
Interaction of aluminium and gallium with human lymphocytes: the role of transferrin.
Biochimica et biophysica acta 1991;1095(3):196-200.
1991: E R Rocha; Milton de Uzeda; Jeremy H Brock
Effect of ferric and ferrous iron chelators on growth of Bacteroides fragilis under anaerobic conditions.
FEMS microbiology letters 1991;68(1):45-50.
1991: Jeremy H Brock; Peter H Williams; J Licéaga; K G Wooldridge
Relative availability of transferrin-bound iron and cell-derived iron to aerobactin-producing and enterochelin-producing strains of Escherichia coli and to other microorganisms.
Infection and immunity 1991;59(9):3185-90.
1991: Jorge Cannata; I Fernández-Soto; M J Fernández-Menendez; José L Fernández-Martín; S J McGregor; Jeremy H Brock; D Halls
Role of iron metabolism in absorption and cellular uptake of aluminum.
Kidney international 1991;39(4):799-803.
1991: S J McGregor; Jeremy H Brock; D Halls
The role of transferrin and citrate in cellular uptake of aluminium.
Biology of metals 1991;4(3):173-5.
1991: M J Fernández Menéndez; G S Fell; Jeremy H Brock; Jorge Cannata
Aluminium uptake by intestinal cells: effect of iron status and precomplexation.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1991;6(9):672-4.
1991: Jorge Cannata; C Gómez Alonso; M J Fernández Menéndez; I Fernández Soto; S McGregor; P Menéndez-Fraga; Jeremy H Brock
Iron uptake in aluminium overload: in vivo and in vitro studies.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1991;6(9):637-42.
1990: S J McGregor; M L Naves; R Oria; J K Vass; Jeremy H Brock
Effect of aluminium on iron uptake and transferrin-receptor expression by human erythroleukaemia K562 cells.
The Biochemical journal 1990;272(2):377-82.
1990: S J McGregor; Jeremy H Brock; J Douglas Briggs; Brian J R Junor
Release of hydrogen peroxide and expression of HLA-DR and transferrin receptors by monocytes and peritoneal macrophages from patients undergoing continuous ambulatory peritoneal dialysis and normal controls.
Clinical immunology and immunopathology 1990;56(2):151-8.
1990: Jeremy H Brock; J Licéaga; H M Arthur; G J Kontoghiorghes
Effect of novel 1-alkyl-3-hydroxy-2-methylpyrid-4-one chelators on uptake and release of iron from macrophages.
American journal of hematology 1990;34(1):21-5.
1990: Fermín Lampreave; Andrés Piñeiro; Jeremy H Brock; H Castillo; L Sánchez; Miguel Calvo
Interaction of bovine lactoferrin with other proteins of milk whey.
International journal of biological macromolecules 1990;12(1):2-5.
1989: X Alvarez-Hernández; J Licéaga; I C McKay; Jeremy H Brock
Induction of hypoferremia and modulation of macrophage iron metabolism by tumor necrosis factor.
Laboratory investigation; a journal of technical methods and pathology 1989;61(3):319-22.
1989: Jeremy H Brock; X Alvarez-Hernandez
Modulation of macrophage iron metabolism by tumour necrosis factor and interleukin 1.
FEMS microbiology immunology 1989;1(5):309.
1989: S J McGregor; Jeremy H Brock; J D Briggs; B J Junor
Properties of human peritoneal macrophages from continuous ambulatory peritoneal dialysis (CAPD) patients.
FEMS microbiology immunology 1989;1(5):303-4.
1989: S J McGregor; Jeremy H Brock; J Douglas Briggs; Brian J R Junor
Longitudinal study of peritoneal defence mechanisms in patients on continuous ambulatory peritoneal dialysis (CAPD).
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 1989;9(2):115-9.
1988: A Hughes; Jeremy H Brock; D M Parrott; F Cockburn
The interaction of infant formula with macrophages: effect on phagocytic activity, relationship to expression of class II MHC antigen and survival of orally administered macrophages in the neonatal gut.
Immunology 1988;64(2):213-8.
1988: R Oria; X Alvarez-Hernández; J Licéaga; Jeremy H Brock
Uptake and handling of iron from transferrin, lactoferrin and immune complexes by a macrophage cell line.
The Biochemical journal 1988;252(1):221-5.
1988: Jeremy H Brock; J Licéaga; G J Kontoghiorghes
The effect of synthetic iron chelators on bacterial growth in human serum.
FEMS microbiology immunology 1988;1(1):55-60.
1988: L S Stewart; J Licéaga; Jeremy H Brock
Inhibition of hydrogen peroxide release from activated macrophages by prior ingestion of erythrocytes or haemoglobin.
FEMS microbiology immunology 1988;1(1):27-30.
1987: A Hughes; Jeremy H Brock; D M Parrott; F Cockburn
Comparison of the effect of human milk and infant formula on macrophage function.
Advances in experimental medicine and biology 1987;216B():1339-45.
1987: Jeremy H Brock; T Mainou-Fowler; S J McGregor
Transferrins and defence against infection.
Annali dell'Istituto superiore di sanità 1987;23(4):935-41.
1987: S J McGregor; Jeremy H Brock; J Douglas Briggs; Brian J R Junor
Relationship of IgG, C3 and transferrin with opsonising and bacteriostatic activity of peritoneal fluid from CAPD patients and the incidence of peritonitis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1987;2(6):551-6.
1987: S J McGregor; Jeremy H Brock; J D Briggs; B J Junor
Bactericidal activity of peritoneal macrophages from continuous ambulatory dialysis patients.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1987;2(2):104-8.
1987: Jeremy H Brock
Iron and infection.
Haematologia 1987;20(4):237-46.
1986: X Alvarez-Hernández; M V Felstein; Jeremy H Brock
The relationship between iron release, ferritin synthesis and intracellular iron distribution in mouse peritoneal macrophages. Evidence for a reduced level of metabolically available iron in elicited macrophages.
Biochimica et biophysica acta 1986;886(2):214-22.
1986: Jeremy H Brock; T Mainou-Fowler; L M Webster
Evidence that transferrin may function exclusively as an iron donor in promoting lymphocyte proliferation.
Immunology 1986;57(1):105-10.
1985: A Hughes; Jeremy H Brock; D M Parrott; F Cockburn
Effect of human colostrum and infant formula on the phagocytic activity of macrophages. I. Resident and stimulated mouse peritoneal macrophages.
Clinical and experimental immunology 1985;61(1):169-75.
1985: T Mainou-Fowler; Jeremy H Brock
Effect of iron deficiency on the response of mouse lymphocytes to concanavalin A: the importance of transferrin-bound iron.
Immunology 1985;54(2):325-32.